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Aliases for BPIFB6 Gene

Aliases for BPIFB6 Gene

  • BPI Fold Containing Family B, Member 6 2 3
  • Bactericidal/Permeability-Increasing Protein-Like 3 2 3 4
  • BPIL3 3 4
  • LPLUNC6 3

External Ids for BPIFB6 Gene

Previous HGNC Symbols for BPIFB6 Gene

  • BPIL3

Previous GeneCards Identifiers for BPIFB6 Gene

  • GC20P031620

Summaries for BPIFB6 Gene

GeneCards Summary for BPIFB6 Gene

BPIFB6 (BPI Fold Containing Family B, Member 6) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB6 Gene

Genomics for BPIFB6 Gene

Genomic Location for BPIFB6 Gene

Chromosome:
20
Start:
33,030,977 bp from pter
End:
33,044,047 bp from pter
Size:
13,071 bases
Orientation:
Plus strand

Genomic View for BPIFB6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BPIFB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB6 Gene

No data available for Regulatory Elements for BPIFB6 Gene

Proteins for BPIFB6 Gene

  • Protein details for BPIFB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFQ5-BPIB6_HUMAN
    Recommended name:
    BPI fold-containing family B member 6
    Protein Accession:
    Q8NFQ5

    Protein attributes for BPIFB6 Gene

    Size:
    453 amino acids
    Molecular mass:
    49717 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFB6 Gene

Proteomics data for BPIFB6 Gene at MOPED

Post-translational modifications for BPIFB6 Gene

  • Glycosylation at Asn 114 and Asn 190
  • Modification sites at PhosphoSitePlus

Other Protein References for BPIFB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFB6 Gene

Domains & Families for BPIFB6 Gene

Gene Families for BPIFB6 Gene

Protein Domains for BPIFB6 Gene

Suggested Antigen Peptide Sequences for BPIFB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFQ5

UniProtKB/Swiss-Prot:

BPIB6_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFB6: view

Function for BPIFB6 Gene

Gene Ontology (GO) - Molecular Function for BPIFB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with BPIFB6: view

Phenotypes for BPIFB6 Gene

genes like me logo Genes that share phenotypes with BPIFB6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPIFB6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPIFB6 Gene

Localization for BPIFB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BPIFB6 Gene COMPARTMENTS Subcellular localization image for BPIFB6 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for BPIFB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with BPIFB6: view

Pathways & Interactions for BPIFB6 Gene

SuperPathways for BPIFB6 Gene

No Data Available

Interacting Proteins for BPIFB6 Gene

Gene Ontology (GO) - Biological Process for BPIFB6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BPIFB6 Gene

Drugs & Compounds for BPIFB6 Gene

No Compound Related Data Available

Transcripts for BPIFB6 Gene

mRNA/cDNA for BPIFB6 Gene

(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPIFB6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB6 Gene

No ASD Table

Relevant External Links for BPIFB6 Gene

GeneLoc Exon Structure for
BPIFB6
ECgene alternative splicing isoforms for
BPIFB6

Expression for BPIFB6 Gene

mRNA expression in normal human tissues for BPIFB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BPIFB6 Gene

This gene is overexpressed in Minor Salivary Gland (x43.1) and Esophagus - Mucosa (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFB6 Gene



SOURCE GeneReport for Unigene cluster for BPIFB6 Gene Hs.375090

mRNA Expression by UniProt/SwissProt for BPIFB6 Gene

Q8NFQ5-BPIB6_HUMAN
Tissue specificity: Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils
genes like me logo Genes that share expression patterns with BPIFB6: view

Protein tissue co-expression partners for BPIFB6 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues for BPIFB6 Gene

Orthologs for BPIFB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BPIFB6 35
  • 86.92 (n)
  • 82.93 (a)
BPIFB6 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BPIFB6 35
  • 85.01 (n)
  • 83.45 (a)
BPIFB6 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bpifb6 35
  • 79.22 (n)
  • 72.87 (a)
Bpifb6 16
Bpifb6 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BPIFB6 35
  • 98.62 (n)
  • 97.47 (a)
BPIFB6 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bpifb6 35
  • 77.08 (n)
  • 71.87 (a)
oppossum
(Monodelphis domestica)
Mammalia BPIFB6 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BPIFB6 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves BPIFB6 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
Species with no ortholog for BPIFB6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB6 Gene

ENSEMBL:
Gene Tree for BPIFB6 (if available)
TreeFam:
Gene Tree for BPIFB6 (if available)

Paralogs for BPIFB6 Gene

Paralogs for BPIFB6 Gene

(1) SIMAP similar genes for BPIFB6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BPIFB6: view

Variants for BPIFB6 Gene

Sequence variations from dbSNP and Humsavar for BPIFB6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs411001 -- 33,043,165(+) CTTTG(C/T)TTGTA intron-variant
rs439255 -- 33,042,918(-) AAGTG(C/T)TTCTT intron-variant
rs451899 -- 33,043,508(-) TCTAG(A/G/T)TTCTG intron-variant
rs761934 -- 33,036,083(+) ACTGA(A/G)GAAAA intron-variant
rs1998113 -- 33,031,156(+) TCAGA(A/G)TTGAG upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFB6 Gene

Variant ID Type Subtype PubMed ID
dgv1325e1 CNV Complex 17122850
essv2996 CNV CNV 17122850
nsv3351 CNV Insertion 18451855
nsv3352 CNV Loss 18451855
dgv4563n71 CNV Loss 21882294

Variation tolerance for BPIFB6 Gene

Residual Variation Intolerance Score: 82.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BPIFB6 Gene

HapMap Linkage Disequilibrium report
BPIFB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFB6 Gene

Disorders for BPIFB6 Gene

Relevant External Links for BPIFB6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPIFB6
genes like me logo Genes that share disorders with BPIFB6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFB6 Gene

Publications for BPIFB6 Gene

  1. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle C.D. … Craven C.J. (Biochem. Soc. Trans. 2011) 2 67
  2. Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). (PMID: 12185532) Mulero J.J. … Rupp F. (Immunogenetics 2002) 2 67
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 67
  4. A de novo paradigm for mental retardation. (PMID: 21076407) Vissers L.E. … Veltman J.A. (Nat. Genet. 2010) 67
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 67

Products for BPIFB6 Gene

Sources for BPIFB6 Gene

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