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Aliases for BPIFB6 Gene

Aliases for BPIFB6 Gene

  • BPI Fold Containing Family B Member 6 2 3 5
  • Bactericidal/Permeability-Increasing Protein-Like 3 2 3 4
  • BPIL3 3 4
  • BPI Fold Containing Family B, Member 6 3
  • LPLUNC6 3

External Ids for BPIFB6 Gene

Previous HGNC Symbols for BPIFB6 Gene

  • BPIL3

Previous GeneCards Identifiers for BPIFB6 Gene

  • GC20P031620

Summaries for BPIFB6 Gene

GeneCards Summary for BPIFB6 Gene

BPIFB6 (BPI Fold Containing Family B Member 6) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB6 Gene

Genomics for BPIFB6 Gene

Regulatory Elements for BPIFB6 Gene

Enhancers for BPIFB6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BPIFB6 on UCSC Golden Path with GeneCards custom track

Genomic Location for BPIFB6 Gene

33,030,977 bp from pter
33,044,047 bp from pter
13,071 bases
Plus strand

Genomic View for BPIFB6 Gene

Genes around BPIFB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB6 Gene

Proteins for BPIFB6 Gene

  • Protein details for BPIFB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BPI fold-containing family B member 6
    Protein Accession:

    Protein attributes for BPIFB6 Gene

    453 amino acids
    Molecular mass:
    49717 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFB6 Gene

Proteomics data for BPIFB6 Gene at MOPED

Post-translational modifications for BPIFB6 Gene

  • Glycosylation at Asn 114 and Asn 190
  • Modification sites at PhosphoSitePlus

Other Protein References for BPIFB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFB6 Gene

Domains & Families for BPIFB6 Gene

Gene Families for BPIFB6 Gene

Suggested Antigen Peptide Sequences for BPIFB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFB6: view

Function for BPIFB6 Gene

Phenotypes for BPIFB6 Gene

genes like me logo Genes that share phenotypes with BPIFB6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BPIFB6

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPIFB6 Gene

Localization for BPIFB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB6 Gene


Subcellular locations from

Jensen Localization Image for BPIFB6 Gene COMPARTMENTS Subcellular localization image for BPIFB6 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
cytosol 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for BPIFB6 Gene

Pathways & Interactions for BPIFB6 Gene

SuperPathways for BPIFB6 Gene

No Data Available

Interacting Proteins for BPIFB6 Gene

Gene Ontology (GO) - Biological Process for BPIFB6 Gene


No data available for Pathways by source and SIGNOR curated interactions for BPIFB6 Gene

Drugs & Compounds for BPIFB6 Gene

No Compound Related Data Available

Transcripts for BPIFB6 Gene

mRNA/cDNA for BPIFB6 Gene

(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB6 Gene

No ASD Table

Relevant External Links for BPIFB6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BPIFB6 Gene

mRNA expression in normal human tissues for BPIFB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BPIFB6 Gene

This gene is overexpressed in Minor Salivary Gland (x43.1) and Esophagus - Mucosa (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFB6 Gene

SOURCE GeneReport for Unigene cluster for BPIFB6 Gene Hs.375090

mRNA Expression by UniProt/SwissProt for BPIFB6 Gene

Tissue specificity: Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils.
genes like me logo Genes that share expression patterns with BPIFB6: view

Protein tissue co-expression partners for BPIFB6 Gene

Primer Products

No data available for Protein differential expression in normal tissues for BPIFB6 Gene

Orthologs for BPIFB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BPIFB6 35
  • 86.92 (n)
  • 82.93 (a)
  • 73 (a)
(Canis familiaris)
Mammalia BPIFB6 35
  • 85.01 (n)
  • 83.45 (a)
  • 83 (a)
(Mus musculus)
Mammalia Bpifb6 35
  • 79.22 (n)
  • 72.87 (a)
Bpifb6 16
Bpifb6 36
  • 72 (a)
(Pan troglodytes)
Mammalia BPIFB6 35
  • 98.62 (n)
  • 97.47 (a)
  • 94 (a)
(Rattus norvegicus)
Mammalia Bpifb6 35
  • 77.08 (n)
  • 71.87 (a)
(Monodelphis domestica)
Mammalia BPIFB6 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia BPIFB6 36
  • 45 (a)
(Gallus gallus)
Aves BPIFB6 36
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
-- 36
  • 20 (a)
-- 36
  • 20 (a)
-- 36
  • 20 (a)
Species with no ortholog for BPIFB6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB6 Gene

Gene Tree for BPIFB6 (if available)
Gene Tree for BPIFB6 (if available)

Paralogs for BPIFB6 Gene

Paralogs for BPIFB6 Gene

(1) SIMAP similar genes for BPIFB6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BPIFB6: view

Variants for BPIFB6 Gene

Sequence variations from dbSNP and Humsavar for BPIFB6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2070317 - 33,034,277(+) TGACC(A/G)TCACT reference, missense
rs17301126 - 33,031,694(+) TGGCA(C/T)GCGAG reference, missense
rs11907355 - 33,034,905(+) ACCTG(A/C)CTAGC reference, missense
rs4911287 - 33,039,485(+) GGCGG(A/G)GCAAG reference, missense
rs79809934 - 33,038,949(+) GGCTC(A/G/T)CTTCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BPIFB6 Gene

Variant ID Type Subtype PubMed ID
dgv1325e1 CNV Complex 17122850
essv2996 CNV CNV 17122850
nsv3351 CNV Insertion 18451855
nsv3352 CNV Loss 18451855
dgv4563n71 CNV Loss 21882294

Variation tolerance for BPIFB6 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BPIFB6 Gene

Disorders for BPIFB6 Gene

Relevant External Links for BPIFB6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BPIFB6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFB6 Gene

Publications for BPIFB6 Gene

  1. Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). (PMID: 12185532) Mulero J.J. … Rupp F. (Immunogenetics 2002) 2 3 4 67
  2. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle C.D. … Craven C.J. (Biochem. Soc. Trans. 2011) 2 3
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  4. Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PMID: 15790807) Cheng J. … Gingeras T.R. (Science 2005) 3
  5. Phylogenetic and evolutionary analysis of the PLUNC gene family. (PMID: 14739326) Bingle C.D. … Craven C.J. (Protein Sci. 2004) 3

Products for BPIFB6 Gene

Sources for BPIFB6 Gene