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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BPIFB6 Gene

protein-coding GIFtS: 44
GCID: GC20P031620

BPI fold containing family B, member 6

(Previous name: bactericidal/permeability-increasing protein-like 3 )
(Previous symbol: BPIL3)

Explore 3 diseases affiliated with
BPIFB6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BPI Fold Containing Family B, Member 6¹ ²
Bactericidal/Permeability-Increasing Protein-Like 3¹ ² ³
BPIL3¹ ² ³
LPLUNC6¹ ²
BPI Fold-Containing Family B Member 6²

External Ids:	HGNC: 16504¹	Entrez Gene: 128859²	Ensembl: ENSG00000167104⁷	OMIM: 614110⁵	UniProtKB: Q8NFQ5³

Export aliases for BPIFB6 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for BPIFB6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BPIFB6 promoter sequence

Search SABiosciences Chromatin IP Primers for BPIFB6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BPIFB6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.21

BPIFB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BPIFB6 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P031620: view genomic region (about GC identifiers)

Start:	31,619,454 bp from pter	End:	31,631,853 bp from pter
Size:	12,400 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: BPIB6_HUMAN, Q8NFQ5 (See protein sequence)

Recommended Name: BPI fold-containing family B member 6 precursor

Size: 453 amino acids; 49717 Da

Subcellular location: Secreted (By similarity)

Explore the universe of human proteins at neXtProt for BPIFB6: NX_Q8NFQ5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NFQ5

BPIFB6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_777557.1

ENSEMBL proteins:

ENSP00000443533 ENSP00000344929

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

BPIFB6 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BPIFB6 for domains About GeneDecksing

3 InterPro domains/families:

IPR017942 Lipid-bd_serum_glycop_N

IPR017943 Bactericidal_perm-incr_a/b_dom

IPR001124 Lipid-bd_serum_glycop_C

Graphical View of Domain Structure for InterPro Entry Q8NFQ5

ProtoNet protein and cluster: Q8NFQ5

UniProtKB/Swiss-Prot: BPIB6_HUMAN, Q8NFQ5

Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008289	lipid binding	IEA	--

BPIFB6 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for BPIFB6:

Cell cycle / mitosis defect

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for BPIFB6

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for BPIFB6 gene:

NM_174897.2

Unigene Cluster for BPIFB6:

BPI fold containing family B, member 6

Hs.375090

Unigene Representative Sequence: BC113122

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000542375(uc010zud.2) ENST00000349552(uc010zuc.2)

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Additional cDNA sequence:

AF465767.1 AY927631.1 BC113122.1

1 DOTS entry:

DT.99936288

2 AceView cDNA sequences:

NM_174897 AF465767

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BPIFB6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTACAATC

About this image

BPIFB6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Granulosa Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BPIFB6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BPIFB6

SOURCE GeneReport for Unigene cluster: Hs.375090

UniProtKB/Swiss-Prot: BPIB6_HUMAN, Q8NFQ5

Tissue specificity: Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB6 gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BPIL3¹	bactericidal/permeability-increasing protein-like 3	54.01(n) 37.98(a)		419290 XM_417463.3 XP_417463.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	20(a) 19(a)	possible ortholog possible ortholog	GL343525.1(442077-453129) GL343766.1(65282-85745)

ENSEMBL Gene Tree for BPIFB6 (if available)
TreeFam Gene Tree for BPIFB6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BPIFB6 gene

BPIFB4² BPIFB2² PLTP² BPIFB3² BPIFC² BPI² LBP²

1 SIMAP similar gene for BPIFB6 using alignment to 2 protein entries: BPIB6_HUMAN (see all proteins):

BPIFB4

BPIFB6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6059025^1,2	C,F,A,H,	--	31617517(+)	`TCTGAG/AGTTGA`	1	--	us2k¹		10		NS EA NA WA CSA	545
rs181944252^1,2		--	31617563(+)	`TGTAAA/GAGCTC`	1	--	us2k¹		0	--	--	--	--
rs11326423^1,2	C,F,	--	31617580(+)	`AAGCTG/-GGGCA`	1	--	us2k¹		4		NA CSA	8
rs187643066^1,2		--	31617719(+)	`TGCACA/GGTCAG`	1	--	us2k¹		0	--	--	--	--
rs189629721^1,2		--	31617763(+)	`CGGGGG/TTTGAG`	1	--	us2k¹		0	--	--	--	--
rs182313991^1,2		--	31617802(+)	`CTGAAA/GTTAGG`	1	--	us2k¹		0	--	--	--	--
rs186712708^1,2		--	31617868(+)	`GGGCAA/GCTTAG`	1	--	us2k¹		0	--	--	--	--
rs6088073^1,2	C,F,A,H,	--	31617871(+)	`CAGCTG/TAGGAC`	1	--	us2k¹ tfbs³		14		EA NS NA WA CSA	744
rs144497532^1,2	C,	--	31617973(+)	`AGGGC-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs11907077^1,2	C,H	--	31618006(+)	`AACACC/CT /T/TCGGCAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BPIFB6 (31619454 - 31631853 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BPIFB6: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BPIFB6 for disorders           About GeneDecksing

OMIM gene information: 614110    OMIM disorders: --

3 diseases for BPIFB6:    About MalaCards

tonsillitis hepatitis b hepatitis

Export disorders for BPIFB6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BPIFB6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BPIFB6)

Utopia: connect your pdf to the dynamic
world of online information

Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). (PubMed id 12185532)^{1, 2, 3} Mulero J.J.... Rupp F. (2002)
Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PubMed id 21787333)^{1, 3} Bingle C.D....Craven C.J. (2011)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
A de novo paradigm for mental retardation. (PubMed id 21076407)² Vissers L.E.... Veltman J.A. (2010)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PubMed id 15790807)¹ Cheng J....Gingeras T.R. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 128859	HGNC: 16504	AceView: BPIL3	Ensembl:ENSG00000167104	euGenes: HUgn128859
ECgene: BPIFB6	H-InvDB: BPIFB6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BPIFB6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BPIFB6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for BPIFB6 gene:
Search GeneIP for patents involving BPIFB6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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BPIFB6 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for BPIFB6

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFB6

	Browse SwitchGear 3'UTR luciferase reporter plasmids for BPIFB6
	SwitchGear Promoter luciferase reporter plasmids for BPIFB6

ThermoFisher Antibodies for BPIFB6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPIFB6

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes BPIFB6 gene at Home site.

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BPIFB6 Gene

BPI fold containing family B, member 6

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for BPIFB6 gene

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for BPIFB6 gene

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Export list of displayed genes

BPIFB6 Gene

BPI fold containing family B, member 6

Aliasesfor BPIFB6 gene

Summariesfor BPIFB6 gene

Genomic Viewsfor BPIFB6 gene

Proteinsfor BPIFB6 gene

Protein Domains /Familiesfor BPIFB6 gene

Functionfor BPIFB6 gene

Pathways & Interactionsfor BPIFB6 gene

Drugs & Compoundsfor BPIFB6 gene

Transcriptsfor BPIFB6 gene

Expression for BPIFB6 gene

Orthologsfor BPIFB6 gene

Paralogsfor BPIFB6 gene

Genomic Variantsfor BPIFB6 gene

Disorders / Diseasesfor BPIFB6 gene

Publicationsfor BPIFB6 gene

External Searches for BPIFB6 gene

Genome Databases showing BPIFB6 gene

Other Databases showing BPIFB6 gene

Specialized Databases showing BPIFB6 gene

Intellectual Propertyfor BPIFB6 gene

Productsfor BPIFB6 gene

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Aliases
for BPIFB6 gene

Summaries
for BPIFB6 gene

Genomic Views
for BPIFB6 gene

Proteins
for BPIFB6 gene

Protein Domains /
Families
for BPIFB6 gene

Function
for BPIFB6 gene

Pathways & Interactions
for BPIFB6 gene

Drugs & Compounds
for BPIFB6 gene

Transcripts
for BPIFB6 gene

Expression
for BPIFB6 gene

Orthologs
for BPIFB6 gene

Paralogs
for BPIFB6 gene

Genomic Variants
for BPIFB6 gene

Disorders / Diseases
for BPIFB6 gene

Publications
for BPIFB6 gene

Intellectual Property
for BPIFB6 gene

Products
for BPIFB6 gene