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Aliases for BPIFB6 Gene

Aliases for BPIFB6 Gene

  • BPI Fold Containing Family B Member 6 2 3 5
  • Bactericidal/Permeability-Increasing Protein-Like 3 2 3 4
  • BPIL3 3 4
  • BPI Fold-Containing Family B Member 6 3
  • LPLUNC6 3

External Ids for BPIFB6 Gene

Previous HGNC Symbols for BPIFB6 Gene

  • BPIL3

Previous GeneCards Identifiers for BPIFB6 Gene

  • GC20P031620

Summaries for BPIFB6 Gene

GeneCards Summary for BPIFB6 Gene

BPIFB6 (BPI Fold Containing Family B Member 6) is a Protein Coding gene. Among its related pathways are Immune System. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB6 Gene

Genomics for BPIFB6 Gene

Regulatory Elements for BPIFB6 Gene

Enhancers for BPIFB6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F032626 1.4 FANTOM5 Ensembl ENCODE 1.6 -402.8 -402813 2.7 PKNOX1 ZNF121 BCLAF1 KDM4B CREM SMARCA5 CREB3 TFDP1 ZFP69B MEF2D NOL4L LOC105372591 COMMD7 BAK1P1 BPIFB6 C20orf203
GH20F033009 1.1 FANTOM5 0.3 -21.4 -21365 0.6 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 ZNF121 SP5 ZHX2 MXD4 BPIFB2 BPIFB6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BPIFB6 on UCSC Golden Path with GeneCards custom track

Genomic Location for BPIFB6 Gene

Chromosome:
20
Start:
33,030,977 bp from pter
End:
33,044,047 bp from pter
Size:
13,071 bases
Orientation:
Plus strand

Genomic View for BPIFB6 Gene

Genes around BPIFB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB6 Gene

Proteins for BPIFB6 Gene

  • Protein details for BPIFB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFQ5-BPIB6_HUMAN
    Recommended name:
    BPI fold-containing family B member 6
    Protein Accession:
    Q8NFQ5

    Protein attributes for BPIFB6 Gene

    Size:
    453 amino acids
    Molecular mass:
    49717 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFB6 Gene

Post-translational modifications for BPIFB6 Gene

  • Glycosylation at Asn 114 and Asn 190
  • Modification sites at PhosphoSitePlus

Other Protein References for BPIFB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFB6 Gene

Domains & Families for BPIFB6 Gene

Gene Families for BPIFB6 Gene

Suggested Antigen Peptide Sequences for BPIFB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFQ5

UniProtKB/Swiss-Prot:

BPIB6_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFB6: view

Function for BPIFB6 Gene

Gene Ontology (GO) - Molecular Function for BPIFB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with BPIFB6: view
genes like me logo Genes that share phenotypes with BPIFB6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BPIFB6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPIFB6 Gene

Localization for BPIFB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BPIFB6 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
golgi apparatus 2
plasma membrane 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for BPIFB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with BPIFB6: view

Pathways & Interactions for BPIFB6 Gene

SuperPathways for BPIFB6 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with BPIFB6: view

Pathways by source for BPIFB6 Gene

2 Reactome pathways for BPIFB6 Gene

Interacting Proteins for BPIFB6 Gene

Gene Ontology (GO) - Biological Process for BPIFB6 Gene

None

No data available for SIGNOR curated interactions for BPIFB6 Gene

Transcripts for BPIFB6 Gene

mRNA/cDNA for BPIFB6 Gene

(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB6 Gene

No ASD Table

Relevant External Links for BPIFB6 Gene

GeneLoc Exon Structure for
BPIFB6
ECgene alternative splicing isoforms for
BPIFB6

Expression for BPIFB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BPIFB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BPIFB6 Gene

This gene is overexpressed in Minor Salivary Gland (x43.1) and Esophagus - Mucosa (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFB6 Gene



Protein tissue co-expression partners for BPIFB6 Gene

NURSA nuclear receptor signaling pathways regulating expression of BPIFB6 Gene:

BPIFB6

SOURCE GeneReport for Unigene cluster for BPIFB6 Gene:

Hs.375090

mRNA Expression by UniProt/SwissProt for BPIFB6 Gene:

Q8NFQ5-BPIB6_HUMAN
Tissue specificity: Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils.
genes like me logo Genes that share expression patterns with BPIFB6: view

Primer Products

No data available for Protein differential expression in normal tissues for BPIFB6 Gene

Orthologs for BPIFB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPIFB6 34 35
  • 98.62 (n)
cow
(Bos Taurus)
Mammalia BPIFB6 34 35
  • 86.92 (n)
dog
(Canis familiaris)
Mammalia BPIFB6 34 35
  • 85.01 (n)
mouse
(Mus musculus)
Mammalia Bpifb6 34 16 35
  • 79.22 (n)
rat
(Rattus norvegicus)
Mammalia Bpifb6 34
  • 77.08 (n)
oppossum
(Monodelphis domestica)
Mammalia BPIFB6 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BPIFB6 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves BPIFB6 35
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 20 (a)
ManyToMany
-- 35
  • 20 (a)
ManyToMany
-- 35
  • 20 (a)
ManyToMany
-- 35
  • 20 (a)
ManyToMany
Species where no ortholog for BPIFB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB6 Gene

ENSEMBL:
Gene Tree for BPIFB6 (if available)
TreeFam:
Gene Tree for BPIFB6 (if available)

Paralogs for BPIFB6 Gene

Paralogs for BPIFB6 Gene

(1) SIMAP similar genes for BPIFB6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BPIFB6: view

Variants for BPIFB6 Gene

Sequence variations from dbSNP and Humsavar for BPIFB6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111323933 -- 33,035,729(+) ATAGA(C/T)TTTGA intron-variant
rs111673221 -- 33,034,385(+) CATCT(G/T)AGTGT intron-variant
rs111727120 -- 33,033,359(+) TCTGC(A/C)TGCAA intron-variant
rs111895205 -- 33,039,850(+) GAGGA(A/G)GTGAT intron-variant
rs111898795 -- 33,036,335(+) AATTT(A/G)CCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFB6 Gene

Variant ID Type Subtype PubMed ID
dgv4301n100 CNV gain 25217958
esv2758792 CNV loss 17122850
esv3567952 CNV loss 25503493
nsv1056411 CNV loss 25217958
nsv1062857 CNV gain 25217958
nsv3351 CNV insertion 18451855
nsv3352 CNV deletion 18451855

Variation tolerance for BPIFB6 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BPIFB6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BPIFB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFB6 Gene

Disorders for BPIFB6 Gene

Relevant External Links for BPIFB6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPIFB6

No disorders were found for BPIFB6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFB6 Gene

Publications for BPIFB6 Gene

  1. Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). (PMID: 12185532) Mulero J.J. … Rupp F. (Immunogenetics 2002) 2 3 4 64
  2. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle C.D. … Craven C.J. (Biochem. Soc. Trans. 2011) 2 3 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication. (PMID: 26962226) Morosky S. … Coyne C.B. (J. Virol. 2016) 3 64
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64

Products for BPIFB6 Gene

Sources for BPIFB6 Gene

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