Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BPIFB4 Gene

Aliases for BPIFB4 Gene

  • BPI Fold Containing Family B, Member 4 2 3
  • Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 4 3 4
  • Ligand-Binding Protein RY2G5 3 4
  • C20orf186 3 4
  • LPLUNC4 3 4
  • RY2G5 3 6
  • Long Palate, Lung And Nasal Epithelium Carcinoma Associated 4 3
  • Likely Ortholog Of Rat Probable Ligand-Binding Protein RY2G5 3
  • BPI Fold-Containing Family B Member 4 3
  • Chromosome 20 Open Reading Frame 186 2
  • DJ726C3.5 3

External Ids for BPIFB4 Gene

Previous Symbols for BPIFB4 Gene

  • C20orf186

Summaries for BPIFB4 Gene

GeneCards Summary for BPIFB4 Gene

BPIFB4 (BPI Fold Containing Family B, Member 4) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB6.

UniProtKB/Swiss-Prot for BPIFB4 Gene

  • May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB4 Gene

Genomics for BPIFB4 Gene

Genomic Location for BPIFB4 Gene

Start:
33,079,644 bp from pter
End:
33,111,751 bp from pter
Size:
32,108 bases
Orientation:
Plus strand

Genomic View for BPIFB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BPIFB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB4 Gene

No data available for Regulatory Elements for BPIFB4 Gene

Proteins for BPIFB4 Gene

  • Protein details for BPIFB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59827-BPIB4_HUMAN
    Recommended name:
    BPI fold-containing family B member 4
    Protein Accession:
    P59827
    Secondary Accessions:
    • Q5TDX6

    Protein attributes for BPIFB4 Gene

    Size:
    614 amino acids
    Molecular mass:
    65055 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI22532.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for BPIFB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BPIFB4 Gene

Proteomics data for BPIFB4 Gene at MOPED

Post-translational modifications for BPIFB4 Gene

Other Protein References for BPIFB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFB4 Gene

Domains for BPIFB4 Gene

Gene Families for BPIFB4 Gene

HGNC:
  • BPIF :BPI fold containing

Graphical View of Domain Structure for InterPro Entry

P59827

UniProtKB/Swiss-Prot:

BPIB4_HUMAN
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.:
    • P59827
genes like me logo Genes that share domains with BPIFB4: view

No data available for Suggested Antigen Peptide Sequences for BPIFB4 Gene

Function for BPIFB4 Gene

Molecular function for BPIFB4 Gene

UniProtKB/Swiss-Prot Function: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).

Gene Ontology (GO) - Molecular Function for BPIFB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with BPIFB4: view

Phenotypes for BPIFB4 Gene

genes like me logo Genes that share phenotypes with BPIFB4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BPIFB4 Gene

Localization for BPIFB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB4 Gene

Secreted. Cytoplasm.

Gene Ontology (GO) - Cellular Components for BPIFB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BPIFB4: view

No data available for Subcellular locations from COMPARTMENTS for BPIFB4 Gene

Pathways for BPIFB4 Gene

SuperPathways for BPIFB4 Gene

No Data Available

Interacting Proteins for BPIFB4 Gene

Gene Ontology (GO) - Biological Process for BPIFB4 Gene

None

No data available for Pathways by source for BPIFB4 Gene

Transcripts for BPIFB4 Gene

mRNA/cDNA for BPIFB4 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BPIFB4 Gene

BPI fold containing family B, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB4 Gene

No ASD Table

Relevant External Links for BPIFB4 Gene

GeneLoc Exon Structure for
BPIFB4
ECgene alternative splicing isoforms for
BPIFB4

Expression for BPIFB4 Gene

mRNA expression in normal human tissues for BPIFB4 Gene

mRNA differential expression in normal tissues according to GTEx for BPIFB4 Gene

This gene is overexpressed in Pituitary (43.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for BPIFB4 Gene

SOURCE GeneReport for Unigene cluster for BPIFB4 Gene Hs.38961

mRNA Expression by UniProt/SwissProt for BPIFB4 Gene

P59827-BPIB4_HUMAN
Tissue specificity: Expressed in nasal tissue.
genes like me logo Genes that share expressions with BPIFB4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BPIFB4 Gene

Orthologs for BPIFB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPIFB4 35
  • 98.76 (n)
  • 98.22 (a)
BPIFB4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BPIFB4 35
  • 87.24 (n)
  • 88.44 (a)
BPIFB4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BPIFB4 35
  • 87.97 (n)
  • 91.22 (a)
BPIFB4 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bpifb4 35
  • 82.92 (n)
  • 86.42 (a)
Bpifb4 16
Bpifb4 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BPIFB4 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BPIFB4 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bpifb4 35
  • 82.54 (n)
  • 86.74 (a)
chicken
(Gallus gallus)
Aves BPIFB4 35
  • 66.75 (n)
  • 65.24 (a)
BPIFB4 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BPIFB4 36
  • 52 (a)
OneToOne
Species with no ortholog for BPIFB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB4 Gene

ENSEMBL:
Gene Tree for BPIFB4 (if available)
TreeFam:
Gene Tree for BPIFB4 (if available)

Paralogs for BPIFB4 Gene

Paralogs for BPIFB4 Gene

Selected SIMAP similar genes for BPIFB4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BPIFB4: view

Variants for BPIFB4 Gene

Sequence variations from dbSNP and Humsavar for BPIFB4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs221983 -- 33,081,661(+) AGGGT(A/T)GGCAT intron-variant
rs221984 -- 33,081,711(+) GGAAC(C/T)TCCTC intron-variant
rs221985 -- 33,081,738(+) CATCG(A/G)GAGGC intron-variant
rs431388 -- 33,080,769(+) tggat(A/G)gatgg upstream-variant-2KB
rs761930 -- 33,099,788(+) TCGTG(A/G)TCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFB4 Gene

Variant ID Type Subtype PubMed ID
dgv1325e1 CNV Complex 17122850
essv2996 CNV CNV 17122850
esv2722351 CNV Deletion 23290073
esv2659207 CNV Deletion 23128226
esv2672617 CNV Deletion 23128226

Relevant External Links for BPIFB4 Gene

HapMap Linkage Disequilibrium report
BPIFB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFB4 Gene

Disorders for BPIFB4 Gene

No disorders were found for BPIFB4 Gene.

No data available for UniProtKB/Swiss-Prot for BPIFB4 Gene

Publications for BPIFB4 Gene

  1. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PMID: 11971875) Bingle C.D. … Craven C.J. (Hum. Mol. Genet. 2002) 2 3 4
  2. Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. (PMID: 12837268) Andrault J.-B. … Rouquier S. (Genomics 2003) 3 4
  3. Phylogenetic and evolutionary analysis of the PLUNC gene family. (PMID: 14739326) Bingle C.D. … Craven C.J. (Protein Sci. 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle C.D. … Craven C.J. (Biochem. Soc. Trans. 2011) 2 3

Products for BPIFB4 Gene

Sources for BPIFB4 Gene

Back to Top

Content