BPIFB4 Gene
protein-coding GIFtS: 39
GCID: GC20P031668
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BPI fold containing family B, member 4(Previous name: chromosome 20 open reading frame 186 )
(Previous symbol: C20orf186)
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Aliases
for BPIFB4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BPI Fold Containing Family B, Member 41 2 | | Chromosome 20 Open Reading Frame 1861 | | C20orf1861 2 3 | | RY2G52 | | LPLUNC41 2 3 | | BPI Fold-Containing Family B Member 42 | | DJ726C3.51 | | Likely Ortholog Of Rat Probable Ligand-Binding Protein RY2G52 | | Ligand-Binding Protein RY2G52 3 | | Long Palate, Lung And Nasal Epithelium Carcinoma Associated 42 | | Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 42 3 | | |
Export aliases for BPIFB4 gene to outside databases |
Summaries
for BPIFB4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BPIB4_HUMAN, P59827Function: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule,transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism byrecognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excessodorant from mucus to enable new odorant stimuli to be received (By similarity)
|
Genomic Views
for BPIFB4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for BPIFB4
Other transcription factors
Search SABiosciences Chromatin IP Primers for BPIFB4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BPIFB4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.21BPIFB4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P031668: view genomic region
(about GC identifiers)
Start:
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31,667,450 bp from pter |
End:
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31,699,557 bp from pter |
Size:
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32,108 bases |
Orientation:
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plus strand |
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Proteins
for BPIFB4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BPIB4_HUMAN, P59827 (See
protein sequence)Recommended Name: BPI fold-containing family B member 4 precursor Size: 614 amino acids; 65055 Da
Subcellular location: Secreted (By similarity). Cytoplasm
Sequence caution: Sequence=CAI22532.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5TDX6Alternative splicing: 2 isoforms: P59827-1 P59827-2 Explore the universe of human proteins at neXtProt for BPIFB4: NX_P59827
BPIFB4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872325.2
ENSEMBL proteins: ENSP00000388423 ENSP00000364632
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005737 | cytoplasm |
IEA | -- |
BPIFB4 for ontologies About GeneDecksing
BPIFB4 Antibody Products:
Assay Products for BPIFB4: |
Protein
Domains /
Families
for BPIFB4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BPIFB4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P59827ProtoNet protein and cluster: P59827 1 Blocks protein family: IPB001124 Lipid-binding serum glycoprotein
UniProtKB/Swiss-Prot: BPIB4_HUMAN, P59827Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family |
Function
for BPIFB4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BPIB4_HUMAN, P59827Function: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule,transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism byrecognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excessodorant from mucus to enable new odorant stimuli to be received (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFB4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008289 | lipid binding |
IEA | -- |
BPIFB4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for BPIFB4:
|
Pathways & Interactions
for BPIFB4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BPIFB4
|
Drugs & Compounds
for BPIFB4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BPIFB4
Search CenterWatch for drugs/clinical trials and news about BPIFB4 / BPIB4
|
Transcripts
for BPIFB4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BPIFB4 gene: NM_182519.2 Unigene Cluster for BPIFB4: BPI fold containing family B, member 4 Hs.38961 [show with all ESTs]Unigene Representative Sequence: NM_1825193 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000445356 ENST00000375483(uc010zue.2) ENST00000494121
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for BPIFB4 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BPIFB4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPIFB4 |
Additional cDNA sequence: AF549190.1 2 DOTS entries: DT.101975507 DT.100749797 20 AceView cDNA sequences: NM_182519 H64406 AF549190 H64418 H65115 CB131812 CB134952 H70942 CB134975 AL935096 BU617498 CB133098 H64469 AL935077 H64455 AL935078 H71030 AL935099 H65167 AL935101
GeneLoc Exon Structure
|
Expression
for BPIFB4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BPIFB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See BPIFB4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BPIFB4
SOURCE GeneReport for Unigene cluster: Hs.38961
UniProtKB/Swiss-Prot: BPIB4_HUMAN, P59827Tissue specificity: Expressed in nasal tissue
SABiosciences Custom PCR Arrays for BPIFB4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BPIFB4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat BPIFB4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BPIFB4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BPIFB4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFB4 |
Orthologs
for BPIFB4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BPIFB4 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for BPIFB4 (if available)
TreeFam Gene Tree for BPIFB4 (if available) |
Paralogs
for BPIFB4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BPIFB4 gene
- BPIFB62 BPIFB22 PLTP2 BPIFB32 BPIFC2 BPI2 LBP2
3 SIMAP similar genes for BPIFB4 using alignment to 2 protein entries: BPIB4_HUMAN (see all proteins):BPIFB6 BPIFB3 C20orf185
BPIFB4 for paralogs About GeneDecksing
|
Genomic Variants
for BPIFB4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BPIFB4 (31667450 - 31699557 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BPIFB4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BPIFB4 |
|
Disorders
/ Diseases
for BPIFB4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BPIFB4 for disorders About GeneDecksing
3  diseases for BPIFB4: About MalaCardscarcinoma hepatitis b hepatitis
Export disorders for BPIFB4 gene to outside databases
|
Publications
for BPIFB4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BPIFB4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BPIFB4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PubMed id 11971875)1, 2, 3 Bingle C.D. and Craven C.J. (2002)
- Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PubMed id 21787333)1, 3 Bingle C.D....Craven C.J. (2011)
- Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. (PubMed id 12837268)1, 2 Andrault J.-B.... Rouquier S. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Phylogenetic and evolutionary analysis of the PLUNC gene family. (PubMed id 14739326)2 Bingle C.D....Craven C.J. (2004)
- Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families. (PubMed id 12887310)1 Bingle C.D. and Craven C.J. (2003)
|
External Searches for BPIFB4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing BPIFB4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BPIFB4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BPIFB4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BPIFB4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BPIFB4 gene:
Search GeneIP for patents involving BPIFB4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BPIFB4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BPIFB4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BPIFB4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BPIFB4 | | | OriGene Protein Over-expression Lysate for BPIFB4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BPIFB4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |  |  |  | |
| | | | Search Tocris compounds for BPIFB4 |
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 | | | BPIFB4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFB4 |
|  |  |  | | | | ThermoFisher Antibodies for BPIFB4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPIFB4 |
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