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Aliases for BPIFB4 Gene

Aliases for BPIFB4 Gene

  • BPI Fold Containing Family B Member 4 2 3 5
  • Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 4 3 4
  • Ligand-Binding Protein RY2G5 3 4
  • C20orf186 3 4
  • LPLUNC4 3 4
  • Long Palate, Lung And Nasal Epithelium Carcinoma Associated 4 3
  • Likely Ortholog Of Rat Probable Ligand-Binding Protein RY2G5 3
  • BPI Fold Containing Family B, Member 4 3
  • Chromosome 20 Open Reading Frame 186 2
  • DJ726C3.5 3
  • RY2G5 3

External Ids for BPIFB4 Gene

Previous HGNC Symbols for BPIFB4 Gene

  • C20orf186

Previous GeneCards Identifiers for BPIFB4 Gene

  • GC20P031668

Summaries for BPIFB4 Gene

GeneCards Summary for BPIFB4 Gene

BPIFB4 (BPI Fold Containing Family B Member 4) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB6.

UniProtKB/Swiss-Prot for BPIFB4 Gene

  • May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB4 Gene

Genomics for BPIFB4 Gene

Regulatory Elements for BPIFB4 Gene

Enhancers for BPIFB4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BPIFB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for BPIFB4 Gene

Chromosome:
20
Start:
33,079,644 bp from pter
End:
33,111,751 bp from pter
Size:
32,108 bases
Orientation:
Plus strand

Genomic View for BPIFB4 Gene

Genes around BPIFB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB4 Gene

Proteins for BPIFB4 Gene

  • Protein details for BPIFB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59827-BPIB4_HUMAN
    Recommended name:
    BPI fold-containing family B member 4
    Protein Accession:
    P59827
    Secondary Accessions:
    • Q5TDX6

    Protein attributes for BPIFB4 Gene

    Size:
    614 amino acids
    Molecular mass:
    65055 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI22532.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for BPIFB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BPIFB4 Gene

Proteomics data for BPIFB4 Gene at MOPED

Post-translational modifications for BPIFB4 Gene

Other Protein References for BPIFB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFB4 Gene

Domains & Families for BPIFB4 Gene

Gene Families for BPIFB4 Gene

Suggested Antigen Peptide Sequences for BPIFB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P59827

UniProtKB/Swiss-Prot:

BPIB4_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFB4: view

Function for BPIFB4 Gene

Molecular function for BPIFB4 Gene

UniProtKB/Swiss-Prot Function:
May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).

Phenotypes for BPIFB4 Gene

GenomeRNAi human phenotypes for BPIFB4:
genes like me logo Genes that share phenotypes with BPIFB4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BPIFB4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPIFB4 Gene

Localization for BPIFB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB4 Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BPIFB4 Gene COMPARTMENTS Subcellular localization image for BPIFB4 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for BPIFB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BPIFB4: view

Pathways & Interactions for BPIFB4 Gene

SuperPathways for BPIFB4 Gene

No Data Available

Interacting Proteins for BPIFB4 Gene

Gene Ontology (GO) - Biological Process for BPIFB4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BPIFB4 Gene

Drugs & Compounds for BPIFB4 Gene

No Compound Related Data Available

Transcripts for BPIFB4 Gene

mRNA/cDNA for BPIFB4 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BPIFB4 Gene

BPI fold containing family B, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB4 Gene

No ASD Table

Relevant External Links for BPIFB4 Gene

GeneLoc Exon Structure for
BPIFB4
ECgene alternative splicing isoforms for
BPIFB4

Expression for BPIFB4 Gene

mRNA expression in normal human tissues for BPIFB4 Gene

mRNA differential expression in normal tissues according to GTEx for BPIFB4 Gene

This gene is overexpressed in Pituitary (x43.8).

Protein differential expression in normal tissues from HIPED for BPIFB4 Gene

This gene is overexpressed in Nasal epithelium (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFB4 Gene



SOURCE GeneReport for Unigene cluster for BPIFB4 Gene Hs.38961

mRNA Expression by UniProt/SwissProt for BPIFB4 Gene

P59827-BPIB4_HUMAN
Tissue specificity: Expressed in nasal tissue.
genes like me logo Genes that share expression patterns with BPIFB4: view

Protein tissue co-expression partners for BPIFB4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BPIFB4 Gene

Orthologs for BPIFB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BPIFB4 35
  • 87.24 (n)
  • 88.44 (a)
BPIFB4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BPIFB4 35
  • 87.97 (n)
  • 91.22 (a)
BPIFB4 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bpifb4 35
  • 82.92 (n)
  • 86.42 (a)
Bpifb4 16
Bpifb4 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BPIFB4 35
  • 98.76 (n)
  • 98.22 (a)
BPIFB4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bpifb4 35
  • 82.54 (n)
  • 86.74 (a)
oppossum
(Monodelphis domestica)
Mammalia BPIFB4 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BPIFB4 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves BPIFB4 35
  • 66.75 (n)
  • 65.24 (a)
BPIFB4 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BPIFB4 36
  • 52 (a)
OneToOne
Species with no ortholog for BPIFB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB4 Gene

ENSEMBL:
Gene Tree for BPIFB4 (if available)
TreeFam:
Gene Tree for BPIFB4 (if available)

Paralogs for BPIFB4 Gene

Paralogs for BPIFB4 Gene

(3) SIMAP similar genes for BPIFB4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BPIFB4: view

Variants for BPIFB4 Gene

Sequence variations from dbSNP and Humsavar for BPIFB4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs4339026 - 33,083,793(+) TGGTG(A/G)TGGAG reference, missense
rs2424943 -, - 33,083,813(+) GAGGA(G/T)GGGGT reference, missense
rs2070325 -, - 33,086,040(+) TGGAC(A/G)TCGCA reference, missense
rs2889732 - 33,088,998(+) AGTGA(A/C)CCGAG reference, missense
rs11699009 - 33,100,435(+) CAGAA(C/G/T)TCTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BPIFB4 Gene

Variant ID Type Subtype PubMed ID
dgv1325e1 CNV Complex 17122850
essv2996 CNV CNV 17122850
esv2722351 CNV Deletion 23290073
esv2659207 CNV Deletion 23128226
esv2672617 CNV Deletion 23128226

Variation tolerance for BPIFB4 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 24.22; 99.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BPIFB4 Gene

Human Gene Mutation Database (HGMD)
BPIFB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFB4 Gene

Disorders for BPIFB4 Gene

Relevant External Links for BPIFB4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPIFB4

No disorders were found for BPIFB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFB4 Gene

Publications for BPIFB4 Gene

  1. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PMID: 11971875) Bingle C.D. … Craven C.J. (Hum. Mol. Genet. 2002) 2 3 4 67
  2. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle C.D. … Craven C.J. (Biochem. Soc. Trans. 2011) 2 3
  3. Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis. (PMID: 26034043) Villa F. … Puca A.A. (Circ. Res. 2015) 3
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  5. Phylogenetic and evolutionary analysis of the PLUNC gene family. (PMID: 14739326) Bingle C.D. … Craven C.J. (Protein Sci. 2004) 3

Products for BPIFB4 Gene

Sources for BPIFB4 Gene

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