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Aliases for BPIFB3 Gene

Aliases for BPIFB3 Gene

  • BPI Fold Containing Family B, Member 3 2 3
  • Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 3 3 4
  • Ligand-Binding Protein RYA3 3 4
  • C20orf185 3 4
  • LPLUNC3 3 4
  • RYA3 3 6
  • BPI Fold-Containing Family B Member 3 3
  • Chromosome 20 Open Reading Frame 185 2
  • BPIFBP3 6

External Ids for BPIFB3 Gene

Previous Symbols for BPIFB3 Gene

  • C20orf185

Summaries for BPIFB3 Gene

GeneCards Summary for BPIFB3 Gene

BPIFB3 (BPI Fold Containing Family B, Member 3) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB6.

UniProtKB/Swiss-Prot for BPIFB3 Gene

  • May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB3 Gene

Genomics for BPIFB3 Gene

Genomic Location for BPIFB3 Gene

Start:
33,055,424 bp from pter
End:
33,073,628 bp from pter
Size:
18,205 bases
Orientation:
Plus strand

Genomic View for BPIFB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BPIFB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB3 Gene

No data available for Regulatory Elements for BPIFB3 Gene

Proteins for BPIFB3 Gene

  • Protein details for BPIFB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59826-BPIB3_HUMAN
    Recommended name:
    BPI fold-containing family B member 3
    Protein Accession:
    P59826
    Secondary Accessions:
    • Q5TDX7

    Protein attributes for BPIFB3 Gene

    Size:
    476 amino acids
    Molecular mass:
    50342 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFB3 Gene

Proteomics data for BPIFB3 Gene at MOPED

Post-translational modifications for BPIFB3 Gene

  • Glycosylation at Asn142, Asn288, and Asn457

Other Protein References for BPIFB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFB3 Gene

Domains for BPIFB3 Gene

Gene Families for BPIFB3 Gene

HGNC:
  • BPIF :BPI fold containing

Protein Domains for BPIFB3 Gene

UniProtKB/Swiss-Prot:

BPIB3_HUMAN
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.:
    • P59826
genes like me logo Genes that share domains with BPIFB3: view

Function for BPIFB3 Gene

Molecular function for BPIFB3 Gene

UniProtKB/Swiss-Prot Function: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).

Gene Ontology (GO) - Molecular Function for BPIFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with BPIFB3: view

Phenotypes for BPIFB3 Gene

MGI mutant phenotypes for BPIFB3:
inferred from 1 alleles
GenomeRNAi human phenotypes for BPIFB3:
genes like me logo Genes that share phenotypes with BPIFB3: view

Animal Models for BPIFB3 Gene

MGI Knock Outs for BPIFB3:

miRNA for BPIFB3 Gene

miRTarBase miRNAs that target BPIFB3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BPIFB3 Gene

Localization for BPIFB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB3 Gene

Secreted. Cytoplasm. Note=According to PubMed:12837268, it is cytoplasmic.

Gene Ontology (GO) - Cellular Components for BPIFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 12837268
genes like me logo Genes that share ontologies with BPIFB3: view

Pathways for BPIFB3 Gene

SuperPathways for BPIFB3 Gene

No Data Available

Interacting Proteins for BPIFB3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364643%0d%0a9606.ENSP00000354394%0d%0a9606.ENSP00000357292%0d%0a
Selected Interacting proteins: ENSP00000364643 P59826-BPIB3_HUMAN for BPIFB3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for BPIFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response NAS 11971875
genes like me logo Genes that share ontologies with BPIFB3: view

No data available for Pathways by source for BPIFB3 Gene

Transcripts for BPIFB3 Gene

mRNA/cDNA for BPIFB3 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB3 Gene

No ASD Table

Relevant External Links for BPIFB3 Gene

GeneLoc Exon Structure for
BPIFB3
ECgene alternative splicing isoforms for
BPIFB3

Expression for BPIFB3 Gene

mRNA expression in normal human tissues for BPIFB3 Gene

mRNA differential expression in normal tissues according to GTEx for BPIFB3 Gene

This gene is overexpressed in Pituitary (27.5) and Testis (24.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BPIFB3 Gene

SOURCE GeneReport for Unigene cluster for BPIFB3 Gene Hs.472442

mRNA Expression by UniProt/SwissProt for BPIFB3 Gene

P59826-BPIB3_HUMAN
Tissue specificity: Detected in nasal septal epithelium.
genes like me logo Genes that share expressions with BPIFB3: view

Orthologs for BPIFB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPIFB3 36
  • 98.95 (n)
  • 98.11 (a)
BPIFB3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BPIFB3 36
  • 84.82 (n)
  • 81.99 (a)
BPIFB3 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BPIFB3 36
  • 84.64 (n)
  • 83.44 (a)
BPIFB3 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bpifb3 36
  • 81.19 (n)
  • 79.08 (a)
Bpifb3 16
Bpifb3 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BPIFB3 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bpifb3 36
  • 79.91 (n)
  • 77.65 (a)
chicken
(Gallus gallus)
Aves BPIFB3 37
  • 36 (a)
OneToOne
BPIL3 36
  • 53.16 (n)
  • 37.92 (a)
lizard
(Anolis carolinensis)
Reptilia BPIFB3 37
  • 30 (a)
OneToOne
Species with no ortholog for BPIFB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB3 Gene

ENSEMBL:
Gene Tree for BPIFB3 (if available)
TreeFam:
Gene Tree for BPIFB3 (if available)

Paralogs for BPIFB3 Gene

Paralogs for BPIFB3 Gene

Selected SIMAP similar genes for BPIFB3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BPIFB3: view

Variants for BPIFB3 Gene

Sequence variations from dbSNP and Humsavar for BPIFB3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs127896 -- 33,053,484(+) GTGCG(A/G)GGGGA upstream-variant-2KB
rs190099 -- 33,060,665(+) CCCGG(C/G)TTCAT intron-variant
rs221976 -- 33,057,514(+) cagaa(C/G)actgc intron-variant
rs221977 -- 33,057,540(+) gttgg(C/T)ccctc intron-variant
rs221978 -- 33,057,549(+) tcaca(C/T)aggat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFB3 Gene

Variant ID Type Subtype PubMed ID
dgv1325e1 CNV Complex 17122850
essv2996 CNV CNV 17122850
nsv3352 CNV Loss 18451855
dgv4563n71 CNV Loss 21882294
esv2668356 CNV Deletion 23128226

Relevant External Links for BPIFB3 Gene

HapMap Linkage Disequilibrium report
BPIFB3

Disorders for BPIFB3 Gene

No disorders were found for BPIFB3 Gene.

No data available for UniProtKB/Swiss-Prot for BPIFB3 Gene

Publications for BPIFB3 Gene

  1. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PMID: 11971875) Bingle C.D. … Craven C.J. (Hum. Mol. Genet. 2002) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle C.D. … Craven C.J. (Biochem. Soc. Trans. 2011) 2 3
  4. Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. (PMID: 12837268) Andrault J.-B. … Rouquier S. (Genomics 2003) 3 4
  5. Phylogenetic and evolutionary analysis of the PLUNC gene family. (PMID: 14739326) Bingle C.D. … Craven C.J. (Protein Sci. 2004) 3

Products for BPIFB3 Gene

Sources for BPIFB3 Gene

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