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Aliases for BPIFB3 Gene

Aliases for BPIFB3 Gene

  • BPI Fold Containing Family B Member 3 2 3 5
  • Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 3 3 4
  • Ligand-Binding Protein RYA3 3 4
  • C20orf185 3 4
  • LPLUNC3 3 4
  • BPI Fold Containing Family B, Member 3 3
  • Chromosome 20 Open Reading Frame 185 2
  • RYA3 3

External Ids for BPIFB3 Gene

Previous HGNC Symbols for BPIFB3 Gene

  • C20orf185

Previous GeneCards Identifiers for BPIFB3 Gene

  • GC20P031645

Summaries for BPIFB3 Gene

GeneCards Summary for BPIFB3 Gene

BPIFB3 (BPI Fold Containing Family B Member 3) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB6.

UniProtKB/Swiss-Prot for BPIFB3 Gene

  • May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB3 Gene

Genomics for BPIFB3 Gene

Regulatory Elements for BPIFB3 Gene

Enhancers for BPIFB3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BPIFB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for BPIFB3 Gene

Chromosome:
20
Start:
33,055,331 bp from pter
End:
33,073,637 bp from pter
Size:
18,307 bases
Orientation:
Plus strand

Genomic View for BPIFB3 Gene

Genes around BPIFB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB3 Gene

Proteins for BPIFB3 Gene

  • Protein details for BPIFB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59826-BPIB3_HUMAN
    Recommended name:
    BPI fold-containing family B member 3
    Protein Accession:
    P59826
    Secondary Accessions:
    • Q5TDX7

    Protein attributes for BPIFB3 Gene

    Size:
    476 amino acids
    Molecular mass:
    50342 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFB3 Gene

Proteomics data for BPIFB3 Gene at MOPED

Post-translational modifications for BPIFB3 Gene

  • Glycosylation at Asn 142, Asn 288, and Asn 457
  • Modification sites at PhosphoSitePlus

Other Protein References for BPIFB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFB3 Gene

Domains & Families for BPIFB3 Gene

Gene Families for BPIFB3 Gene

Suggested Antigen Peptide Sequences for BPIFB3 Gene

Graphical View of Domain Structure for InterPro Entry

P59826

UniProtKB/Swiss-Prot:

BPIB3_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFB3: view

Function for BPIFB3 Gene

Molecular function for BPIFB3 Gene

UniProtKB/Swiss-Prot Function:
May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).
genes like me logo Genes that share phenotypes with BPIFB3: view

Animal Models for BPIFB3 Gene

MGI Knock Outs for BPIFB3:

Animal Model Products

miRNA for BPIFB3 Gene

miRTarBase miRNAs that target BPIFB3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BPIFB3 Gene

Localization for BPIFB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB3 Gene

Secreted. Cytoplasm. Note=According to PubMed:12837268, it is cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BPIFB3 Gene COMPARTMENTS Subcellular localization image for BPIFB3 gene
Compartment Confidence
extracellular 4
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for BPIFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12837268
genes like me logo Genes that share ontologies with BPIFB3: view

Pathways & Interactions for BPIFB3 Gene

SuperPathways for BPIFB3 Gene

No Data Available

Interacting Proteins for BPIFB3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364643%0d%0a9606.ENSP00000354394%0d%0a9606.ENSP00000357292%0d%0a
Selected Interacting proteins: ENSP00000364643 P59826-BPIB3_HUMAN for BPIFB3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for BPIFB3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BPIFB3 Gene

Drugs & Compounds for BPIFB3 Gene

No Compound Related Data Available

Transcripts for BPIFB3 Gene

mRNA/cDNA for BPIFB3 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB3 Gene

No ASD Table

Relevant External Links for BPIFB3 Gene

GeneLoc Exon Structure for
BPIFB3
ECgene alternative splicing isoforms for
BPIFB3

Expression for BPIFB3 Gene

mRNA expression in normal human tissues for BPIFB3 Gene

mRNA differential expression in normal tissues according to GTEx for BPIFB3 Gene

This gene is overexpressed in Pituitary (x27.5) and Testis (x24.8).

Protein differential expression in normal tissues from HIPED for BPIFB3 Gene

This gene is overexpressed in Bone (48.8), Plasma (10.0), and Tlymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFB3 Gene



SOURCE GeneReport for Unigene cluster for BPIFB3 Gene Hs.472442

mRNA Expression by UniProt/SwissProt for BPIFB3 Gene

P59826-BPIB3_HUMAN
Tissue specificity: Detected in nasal septal epithelium.
genes like me logo Genes that share expression patterns with BPIFB3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for BPIFB3 Gene

Orthologs for BPIFB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BPIFB3 35
  • 84.82 (n)
  • 81.99 (a)
BPIFB3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BPIFB3 35
  • 84.64 (n)
  • 83.44 (a)
BPIFB3 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bpifb3 35
  • 81.19 (n)
  • 79.08 (a)
Bpifb3 16
Bpifb3 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BPIFB3 35
  • 98.95 (n)
  • 98.11 (a)
BPIFB3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bpifb3 35
  • 79.91 (n)
  • 77.65 (a)
oppossum
(Monodelphis domestica)
Mammalia BPIFB3 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves BPIL3 35
  • 53.16 (n)
  • 37.92 (a)
BPIFB3 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BPIFB3 36
  • 30 (a)
OneToOne
Species with no ortholog for BPIFB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB3 Gene

ENSEMBL:
Gene Tree for BPIFB3 (if available)
TreeFam:
Gene Tree for BPIFB3 (if available)

Paralogs for BPIFB3 Gene

Paralogs for BPIFB3 Gene

(2) SIMAP similar genes for BPIFB3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BPIFB3: view

Variants for BPIFB3 Gene

Sequence variations from dbSNP and Humsavar for BPIFB3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs4911290 - 33,064,486(+) GGTCC(A/C/G)TGGAA reference, missense
rs2093066 - 33,064,790(+) CACCA(C/T)GTTTG reference, missense
rs6057717 - 33,068,826(+) CTGCA(A/C/G)CAGCA reference, missense
rs6059063 - 33,068,930(+) GTTCT(A/G)TGTCC reference, missense
rs378098 - 33,072,737(+) GAATT(C/T)CCCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BPIFB3 Gene

Variant ID Type Subtype PubMed ID
dgv1325e1 CNV Complex 17122850
essv2996 CNV CNV 17122850
nsv3352 CNV Loss 18451855
dgv4563n71 CNV Loss 21882294
esv2668356 CNV Deletion 23128226

Variation tolerance for BPIFB3 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.36; 99.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BPIFB3 Gene

Disorders for BPIFB3 Gene

Relevant External Links for BPIFB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPIFB3

No disorders were found for BPIFB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFB3 Gene

Publications for BPIFB3 Gene

  1. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PMID: 11971875) Bingle C.D. … Craven C.J. (Hum. Mol. Genet. 2002) 2 3 4 67
  2. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle C.D. … Craven C.J. (Biochem. Soc. Trans. 2011) 2 3
  3. BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation machinery. (PMID: 25491355) Delorme-Axford E. … Coyne C.B. (MBio 2014) 3
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for BPIFB3 Gene

Sources for BPIFB3 Gene

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