BPIFB3 Gene
protein-coding GIFtS: 38
GCID: GC20P031645
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BPI fold containing family B, member 3(Previous name: chromosome 20 open reading frame 185 )
(Previous symbol: C20orf185)
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Aliases
for BPIFB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BPI Fold Containing Family B, Member 31 2 | | Ligand-Binding Protein RYA32 3 | | C20orf1851 2 3 | | Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 32 3 | | LPLUNC31 2 3 | | Chromosome 20 Open Reading Frame 1851 | | RYA31 2 | | BPI Fold-Containing Family B Member 32 | | DJ726C3.41 | | Long Palate, Lung And Nasal Epithelium Carcinoma Associated 32 |
Export aliases for BPIFB3 gene to outside databases |
Summaries
for BPIFB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BPIB3_HUMAN, P59826Function: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule,transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism byrecognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excessodorant from mucus to enable new odorant stimuli to be received (By similarity)
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Genomic Views
for BPIFB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for BPIFB3
Other transcription factors
Search SABiosciences Chromatin IP Primers for BPIFB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BPIFB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.21BPIFB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P031645: view genomic region
(about GC identifiers)
Start:
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31,643,230 bp from pter |
End:
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31,661,434 bp from pter |
Size:
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18,205 bases |
Orientation:
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plus strand |
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Proteins
for BPIFB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BPIB3_HUMAN, P59826 (See
protein sequence)Recommended Name: BPI fold-containing family B member 3 precursor Size: 476 amino acids; 50342 Da
Subcellular location: Secreted (By similarity). Cytoplasm. Note=According to PubMed:12837268, it is cytoplasmic
Secondary accessions: Q5TDX7Explore the universe of human proteins at neXtProt for BPIFB3: NX_P59826
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P59826
BPIFB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872599.1
ENSEMBL proteins: ENSP00000364643
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
BPIFB3 for ontologies About GeneDecksing
BPIFB3 Antibody Products:
Assay Products for BPIFB3: |
Protein
Domains /
Families
for BPIFB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BPIFB3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P59826ProtoNet protein and cluster: P59826 UniProtKB/Swiss-Prot: BPIB3_HUMAN, P59826Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family |
Function
for BPIFB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BPIB3_HUMAN, P59826Function: May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule,transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism byrecognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excessodorant from mucus to enable new odorant stimuli to be received (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for BPIFB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPIFB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFB3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
BPIFB3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for BPIFB3:
Animal Models:
Mouse knock-out Bpifb3tm1Lex for BPIFB3
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Bpifb3):
BPIFB3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for BPIFB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BPIFB3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for BPIFB3 (P598263 ENSP000003646434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
BPIFB3 for ontologies About GeneDecksing
|
Drugs & Compounds
for BPIFB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BPIFB3
Search CenterWatch for drugs/clinical trials and news about BPIFB3 / BPIB3
|
Transcripts
for BPIFB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BPIFB3 gene: NM_182658.1 Unigene Cluster for BPIFB3: BPI fold containing family B, member 3 Hs.472442 Unigene Representative Sequence: BC1133981 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000375494(uc002wym.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for BPIFB3 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BPIFB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPIFB3 |
Additional cDNA sequence: AF549189.1 BC113398.1 BC113400.1 1 DOTS entry: DT.101976619 2 AceView cDNA sequences: NM_182658 AF549189
GeneLoc Exon Structure
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Expression
for BPIFB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BPIFB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCACCAGCC
About this image
See BPIFB3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.472442
UniProtKB/Swiss-Prot: BPIB3_HUMAN, P59826Tissue specificity: Detected in nasal septal epithelium
SABiosciences Custom PCR Arrays for BPIFB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BPIFB3
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat BPIFB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BPIFB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BPIFB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFB3 |
Orthologs
for BPIFB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BPIFB3 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for BPIFB3 (if available)
TreeFam Gene Tree for BPIFB3 (if available) |
Paralogs
for BPIFB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BPIFB3 gene
- BPIFB42 BPIFB62 BPIFB22 PLTP2 BPIFC2 BPI2 LBP2
2 SIMAP similar genes for BPIFB3 using alignment to 1 protein entry: BPIB3_HUMAN:C20orf185 BPIFB4
BPIFB3 for paralogs About GeneDecksing
|
Genomic Variants
for BPIFB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BPIFB3 (31643230 - 31661434 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BPIFB3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BPIFB3 |
|
Disorders
/ Diseases
for BPIFB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BPIFB3 for disorders About GeneDecksing
3  diseases for BPIFB3: About MalaCardscarcinoma hepatitis b hepatitis
Export disorders for BPIFB3 gene to outside databases
|
Publications
for BPIFB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BPIFB3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BPIFB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PubMed id 11971875)1, 2, 3 Bingle C.D. and Craven C.J. (2002)
- Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PubMed id 21787333)1, 3 Bingle C.D....Craven C.J. (2011)
- Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. (PubMed id 12837268)1, 2 Andrault J.-B.... Rouquier S. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for BPIFB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing BPIFB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BPIFB3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BPIFB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BPIFB3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for BPIFB3 gene:
Search GeneIP for patents involving BPIFB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BPIFB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BPIFB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BPIFB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BPIFB3 | | | OriGene Protein Over-expression Lysate for BPIFB3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BPIFB3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for BPIFB3 |
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 | | | BPIFB3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFB3 |
|  |  |  | | | | Search ThermoFisher Antibodies for BPIFB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPIFB3 |
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