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Aliases for BPIFB2 Gene

Aliases for BPIFB2 Gene

  • BPI Fold Containing Family B Member 2 2 3 5
  • Bactericidal/Permeability-Increasing Protein-Like 1 2 3 4
  • Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 2 3 4
  • BPI-Like 1 3 4
  • C20orf184 3 4
  • LPLUNC2 3 4
  • BPIL1 3 4
  • RYSR 3 4
  • BPI Fold Containing Family B, Member 2 3
  • DJ726C3.2 3

External Ids for BPIFB2 Gene

Previous HGNC Symbols for BPIFB2 Gene

  • C20orf184
  • BPIL1

Previous GeneCards Identifiers for BPIFB2 Gene

  • GC20P031596

Summaries for BPIFB2 Gene

Entrez Gene Summary for BPIFB2 Gene

  • This gene encodes a member of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) gene family. It is highly expressed in hypertrophic tonsils. This gene and three other members of the LT/LBP gene family form a cluster on the long arm of chromosome 20. [provided by RefSeq, Jul 2008]

GeneCards Summary for BPIFB2 Gene

BPIFB2 (BPI Fold Containing Family B Member 2) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB6.

Gene Wiki entry for BPIFB2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB2 Gene

Genomics for BPIFB2 Gene

Regulatory Elements for BPIFB2 Gene

Enhancers for BPIFB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BPIFB2 on UCSC Golden Path with GeneCards custom track

Promoters for BPIFB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BPIFB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BPIFB2 Gene

33,007,578 bp from pter
33,023,709 bp from pter
16,132 bases
Plus strand

Genomic View for BPIFB2 Gene

Genes around BPIFB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB2 Gene

Proteins for BPIFB2 Gene

  • Protein details for BPIFB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BPI fold-containing family B member 2
    Protein Accession:
    Secondary Accessions:
    • Q6UWN3
    • Q6ZME0
    • Q8NFQ7

    Protein attributes for BPIFB2 Gene

    458 amino acids
    Molecular mass:
    49172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFB2 Gene

Proteomics data for BPIFB2 Gene at MOPED

Post-translational modifications for BPIFB2 Gene

  • Glycosylation at Asn 96, Asn 151, Asn 293, and Asn 332
  • Modification sites at PhosphoSitePlus

Other Protein References for BPIFB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for BPIL1

No data available for DME Specific Peptides for BPIFB2 Gene

Domains & Families for BPIFB2 Gene

Gene Families for BPIFB2 Gene

Suggested Antigen Peptide Sequences for BPIFB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFB2: view

Function for BPIFB2 Gene

Phenotypes for BPIFB2 Gene

genes like me logo Genes that share phenotypes with BPIFB2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BPIFB2

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPIFB2 Gene

Localization for BPIFB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB2 Gene


Subcellular locations from

Jensen Localization Image for BPIFB2 Gene COMPARTMENTS Subcellular localization image for BPIFB2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BPIFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with BPIFB2: view

Pathways & Interactions for BPIFB2 Gene

SuperPathways for BPIFB2 Gene

No Data Available

Interacting Proteins for BPIFB2 Gene

Gene Ontology (GO) - Biological Process for BPIFB2 Gene


No data available for Pathways by source and SIGNOR curated interactions for BPIFB2 Gene

Drugs & Compounds for BPIFB2 Gene

No Compound Related Data Available

Transcripts for BPIFB2 Gene

mRNA/cDNA for BPIFB2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BPIFB2 Gene

BPI fold containing family B, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB2 Gene

No ASD Table

Relevant External Links for BPIFB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BPIFB2 Gene

mRNA expression in normal human tissues for BPIFB2 Gene

mRNA differential expression in normal tissues according to GTEx for BPIFB2 Gene

This gene is overexpressed in Minor Salivary Gland (x48.8).

Protein differential expression in normal tissues from HIPED for BPIFB2 Gene

This gene is overexpressed in Saliva (32.6), Oral epithelium (22.9), and Salivary gland (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFB2 Gene

SOURCE GeneReport for Unigene cluster for BPIFB2 Gene Hs.257045

mRNA Expression by UniProt/SwissProt for BPIFB2 Gene

Tissue specificity: Highly expressed in tonsils, especially in hypertrophic tonsils. Detected at very low levels in fetal liver.
genes like me logo Genes that share expression patterns with BPIFB2: view

Protein tissue co-expression partners for BPIFB2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BPIFB2 Gene

Orthologs for BPIFB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BPIFB2 35
  • 81.37 (n)
  • 73.53 (a)
  • 72 (a)
(Canis familiaris)
Mammalia BPIFB2 35
  • 83.15 (n)
  • 78.34 (a)
BPIL1 36
  • 78 (a)
(Mus musculus)
Mammalia Bpifb2 35
  • 77.85 (n)
  • 68.48 (a)
Bpifb2 16
Bpifb2 36
  • 66 (a)
(Pan troglodytes)
Mammalia BPIFB2 35
  • 99.49 (n)
  • 99.34 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Bpifb2 35
  • 77.83 (n)
  • 69.58 (a)
(Monodelphis domestica)
Mammalia BPIFB2 36
  • 43 (a)
(Gallus gallus)
Aves BPIFB8 36
  • 17 (a)
(Anolis carolinensis)
Reptilia BPIFB2 36
  • 35 (a)
Species with no ortholog for BPIFB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB2 Gene

Gene Tree for BPIFB2 (if available)
Gene Tree for BPIFB2 (if available)

Paralogs for BPIFB2 Gene

Paralogs for BPIFB2 Gene

genes like me logo Genes that share paralogs with BPIFB2: view

Variants for BPIFB2 Gene

Sequence variations from dbSNP and Humsavar for BPIFB2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6088066 - 33,008,666(+) CAACA(A/G/T)GGCAG reference, missense
VAR_036550 A colorectal cancer sample
rs34128772 - 33,011,102(-) GAAGC(A/G/T)CCTCT reference, missense
rs743171 -- 33,020,037(-) GGTGC(C/T)GAGAA intron-variant
rs2024935 -- 33,013,185(+) AAGTG(C/T)CAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFB2 Gene

Variant ID Type Subtype PubMed ID
dgv1325e1 CNV Complex 17122850
essv2996 CNV CNV 17122850
nsv3351 CNV Insertion 18451855
nsv3352 CNV Loss 18451855

Variation tolerance for BPIFB2 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BPIFB2 Gene

Disorders for BPIFB2 Gene

Relevant External Links for BPIFB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BPIFB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFB2 Gene

Publications for BPIFB2 Gene

  1. Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). (PMID: 12185532) Mulero J.J. … Rupp F. (Immunogenetics 2002) 2 3 4 67
  2. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle C.D. … Craven C.J. (Biochem. Soc. Trans. 2011) 2 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P. … Loo J.A. (J. Proteome Res. 2006) 3

Products for BPIFB2 Gene

Sources for BPIFB2 Gene