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Aliases for BPIFB2 Gene

Aliases for BPIFB2 Gene

  • BPI Fold Containing Family B Member 2 2 3 5
  • Bactericidal/Permeability-Increasing Protein-Like 1 2 3 4
  • Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 2 3 4
  • BPI-Like 1 3 4
  • C20orf184 3 4
  • LPLUNC2 3 4
  • BPIL1 3 4
  • RYSR 3 4
  • BPI Fold-Containing Family B Member 2 3
  • DJ726C3.2 3

External Ids for BPIFB2 Gene

Previous HGNC Symbols for BPIFB2 Gene

  • C20orf184
  • BPIL1

Previous GeneCards Identifiers for BPIFB2 Gene

  • GC20P031596

Summaries for BPIFB2 Gene

Entrez Gene Summary for BPIFB2 Gene

  • This gene encodes a member of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) gene family. It is highly expressed in hypertrophic tonsils. This gene and three other members of the LT/LBP gene family form a cluster on the long arm of chromosome 20. [provided by RefSeq, Jul 2008]

GeneCards Summary for BPIFB2 Gene

BPIFB2 (BPI Fold Containing Family B Member 2) is a Protein Coding gene. Among its related pathways are Defensins and Innate Immune System. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFB3.

Gene Wiki entry for BPIFB2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB2 Gene

Genomics for BPIFB2 Gene

Regulatory Elements for BPIFB2 Gene

Enhancers for BPIFB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G033009 1.3 FANTOM5 dbSUPER 5.3 +2.0 2035 0.6 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 ZNF121 SP5 ZHX2 BPIFB2 BPIFB6
GH20G033285 0.4 FANTOM5 5.3 +277.6 277585 0.2 ZFP3 BPIFB1 BPIFA1 BPIFA3 ENSG00000224876 BPIFB2 PIR39691
GH20G033005 0.8 ENCODE 0.7 -2.3 -2319 0.1 HDAC1 CTCF CHD4 CEBPG RAD21 ZNF644 ZNF143 SMC3 FOS SMARCE1 BPIFB2 SUN5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BPIFB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BPIFB2 Gene

Chromosome:
20
Start:
33,007,578 bp from pter
End:
33,023,709 bp from pter
Size:
16,132 bases
Orientation:
Plus strand

Genomic View for BPIFB2 Gene

Genes around BPIFB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB2 Gene

Proteins for BPIFB2 Gene

  • Protein details for BPIFB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4F0-BPIB2_HUMAN
    Recommended name:
    BPI fold-containing family B member 2
    Protein Accession:
    Q8N4F0
    Secondary Accessions:
    • Q6UWN3
    • Q6ZME0
    • Q8NFQ7

    Protein attributes for BPIFB2 Gene

    Size:
    458 amino acids
    Molecular mass:
    49172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFB2 Gene

Post-translational modifications for BPIFB2 Gene

  • Glycosylation at posLast=9696, Asn151, Asn293, and posLast=332332
  • Modification sites at PhosphoSitePlus

Other Protein References for BPIFB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFB2 Gene

Domains & Families for BPIFB2 Gene

Gene Families for BPIFB2 Gene

Suggested Antigen Peptide Sequences for BPIFB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4F0

UniProtKB/Swiss-Prot:

BPIB2_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFB2: view

Function for BPIFB2 Gene

Gene Ontology (GO) - Molecular Function for BPIFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with BPIFB2: view

Phenotypes for BPIFB2 Gene

genes like me logo Genes that share phenotypes with BPIFB2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BPIFB2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPIFB2 Gene

Localization for BPIFB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BPIFB2 gene
Compartment Confidence
extracellular 5
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for BPIFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with BPIFB2: view

Pathways & Interactions for BPIFB2 Gene

genes like me logo Genes that share pathways with BPIFB2: view

Pathways by source for BPIFB2 Gene

3 Reactome pathways for BPIFB2 Gene

Interacting Proteins for BPIFB2 Gene

Selected Interacting proteins: Q8N4F0-BPIB2_HUMAN for BPIFB2 Gene via IID

Symbol External ID(s) Details
AZGP1

Gene Ontology (GO) - Biological Process for BPIFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019730 antimicrobial humoral response TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with BPIFB2: view

No data available for SIGNOR curated interactions for BPIFB2 Gene

Drugs & Compounds for BPIFB2 Gene

No Compound Related Data Available

Transcripts for BPIFB2 Gene

mRNA/cDNA for BPIFB2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BPIFB2 Gene

BPI fold containing family B, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB2 Gene

No ASD Table

Relevant External Links for BPIFB2 Gene

GeneLoc Exon Structure for
BPIFB2
ECgene alternative splicing isoforms for
BPIFB2

Expression for BPIFB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BPIFB2 Gene

mRNA differential expression in normal tissues according to GTEx for BPIFB2 Gene

This gene is overexpressed in Minor Salivary Gland (x48.8).

Protein differential expression in normal tissues from HIPED for BPIFB2 Gene

This gene is overexpressed in Saliva (32.6), Oral epithelium (22.9), and Salivary gland (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFB2 Gene



Protein tissue co-expression partners for BPIFB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BPIFB2 Gene:

BPIFB2

SOURCE GeneReport for Unigene cluster for BPIFB2 Gene:

Hs.257045

mRNA Expression by UniProt/SwissProt for BPIFB2 Gene:

Q8N4F0-BPIB2_HUMAN
Tissue specificity: Highly expressed in tonsils, especially in hypertrophic tonsils. Detected at very low levels in fetal liver.

Evidence on tissue expression from TISSUES for BPIFB2 Gene

  • Lung(4.2)
  • Saliva(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with BPIFB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for BPIFB2 Gene

Orthologs for BPIFB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPIFB2 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia BPIFB2 34
  • 83.15 (n)
BPIL1 35
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BPIFB2 34 35
  • 81.37 (n)
mouse
(Mus musculus)
Mammalia Bpifb2 34 16 35
  • 77.85 (n)
rat
(Rattus norvegicus)
Mammalia Bpifb2 34
  • 77.83 (n)
oppossum
(Monodelphis domestica)
Mammalia BPIFB2 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves BPIFB8 35
  • 17 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia BPIFB2 35
  • 35 (a)
OneToOne
Species where no ortholog for BPIFB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB2 Gene

ENSEMBL:
Gene Tree for BPIFB2 (if available)
TreeFam:
Gene Tree for BPIFB2 (if available)

Paralogs for BPIFB2 Gene

Paralogs for BPIFB2 Gene

genes like me logo Genes that share paralogs with BPIFB2: view

Variants for BPIFB2 Gene

Sequence variations from dbSNP and Humsavar for BPIFB2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_036550 A colorectal cancer sample
rs1000318524 -- 33,013,012(+) CCAGG(C/T)CTCTT intron-variant
rs1000445001 -- 33,007,662(+) CTGCA(C/T)ATTGG utr-variant-5-prime
rs1000540211 -- 33,011,985(+) AAAAC(A/C)AAAAA intron-variant
rs1000640810 -- 33,006,382(+) TTGGG(A/T)GGCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BPIFB2 Gene

Variant ID Type Subtype PubMed ID
esv2758792 CNV loss 17122850
nsv1056411 CNV loss 25217958
nsv3351 CNV insertion 18451855
nsv3352 CNV deletion 18451855

Variation tolerance for BPIFB2 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BPIFB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BPIFB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFB2 Gene

Disorders for BPIFB2 Gene

Relevant External Links for BPIFB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPIFB2

No disorders were found for BPIFB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFB2 Gene

Publications for BPIFB2 Gene

  1. Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). (PMID: 12185532) Mulero J.J. … Rupp F. (Immunogenetics 2002) 2 3 4 64
  2. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle C.D. … Craven C.J. (Biochem. Soc. Trans. 2011) 2 3 64
  3. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P. … Loo J.A. (J. Proteome Res. 2006) 3 4 64
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for BPIFB2 Gene

Sources for BPIFB2 Gene

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