BPIFB2 Gene
protein-coding GIFtS: 41
GCID: GC20P031596
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BPI fold containing family B, member 2(Previous name: bactericidal/permeability-increasing protein-like 1 )
(Previous symbols: C20orf184, BPIL1)
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Aliases
for BPIFB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BPI Fold Containing Family B, Member 21 2 | | DJ726C3.21 | | Bactericidal/Permeability-Increasing Protein-Like 11 2 3 | | Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 22 3 | | BPIL11 2 3 | | RYSR2 3 | | C20orf1841 2 3 | | BPI-Like 12 3 | | LPLUNC21 2 3 | | BPI Fold-Containing Family B Member 22 |
Export aliases for BPIFB2 gene to outside databases |
Summaries
for BPIFB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BPIFB2:
This gene encodes a member of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) gene family. It is highlyexpressed in hypertrophic tonsils. This gene and three other members of the LT/LBP gene family form a cluster on thelong arm of chromosome 20. (provided by RefSeq, Jul 2008)
Gene Wiki entry for BPIFB2 (BPIL1)
|
Genomic Views
for BPIFB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for BPIFB2
Other transcription factors
Search SABiosciences Chromatin IP Primers for BPIFB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BPIFB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.21BPIFB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P031596: view genomic region
(about GC identifiers)
Start:
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31,595,406 bp from pter |
End:
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31,611,515 bp from pter |
Size:
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16,110 bases |
Orientation:
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plus strand |
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Proteins
for BPIFB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BPIB2_HUMAN, Q8N4F0 (See
protein sequence)Recommended Name: BPI fold-containing family B member 2 precursor Size: 458 amino acids; 49172 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: Q6UWN3 Q6ZME0 Q8NFQ7Explore the universe of human proteins at neXtProt for BPIFB2: NX_Q8N4F0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N4F0
BPIFB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079503.1
ENSEMBL proteins: ENSP00000170150
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
BPIFB2 for ontologies About GeneDecksing
BPIFB2 Antibody Products:
Assay Products for BPIFB2: |
Protein
Domains /
Families
for BPIFB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BPIFB2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N4F0ProtoNet protein and cluster: Q8N4F0 UniProtKB/Swiss-Prot: BPIB2_HUMAN, Q8N4F0Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family |
Function
for BPIFB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFB2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008289 | lipid binding |
IEA | -- |
BPIFB2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for BPIFB2:
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Pathways & Interactions
for BPIFB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BPIFB2
|
Drugs & Compounds
for BPIFB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BPIFB2
Search CenterWatch for drugs/clinical trials and news about BPIFB2 / BPIB2
|
Transcripts
for BPIFB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BPIFB2 gene: NM_025227.2 Unigene Cluster for BPIFB2: BPI fold containing family B, member 2 Hs.257045 [show with all ESTs]Unigene Representative Sequence: AK1728191 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000170150(uc002wyj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for BPIFB2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BPIFB2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPIFB2 |
Additional cDNA sequence: AF465765.1 AK027068.1 AK172819.1 AK304064.1 AY358723.1 BC034415.1 2 DOTS entries: DT.92031367 DT.120807540 18 AceView cDNA sequences: BX280449 NM_025227 AF465765 BF512164 AK027068 BC034415 BP333980 AY358723 AK172819 BI489783 AJ403122 AJ403124 AI834221 AW155639 BX487536 CD697627 AW444867 BP334787
GeneLoc Exon Structure
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Expression
for BPIFB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BPIFB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAATTGCCC
About this image
See BPIFB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BPIFB2
SOURCE GeneReport for Unigene cluster: Hs.257045
UniProtKB/Swiss-Prot: BPIB2_HUMAN, Q8N4F0Tissue specificity: Highly expressed in tonsils, especially in hypertrophic tonsils. Detected at very low levels infetal liver
SABiosciences Custom PCR Arrays for BPIFB2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BPIFB2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat BPIFB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BPIFB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BPIFB2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFB2 |
Orthologs
for BPIFB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BPIFB2 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for BPIFB2 (if available)
TreeFam Gene Tree for BPIFB2 (if available) |
Paralogs
for BPIFB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BPIFB2 gene
- BPIFB42 BPIFB62 PLTP2 BPIFB32 BPIFC2 BPI2 LBP2
BPIFB2 for paralogs About GeneDecksing
|
Genomic Variants
for BPIFB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BPIFB2 (31595406 - 31611515 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BPIFB2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BPIFB2 |
|
Disorders
/ Diseases
for BPIFB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BPIFB2 for disorders About GeneDecksing
OMIM gene information: 614108
OMIM disorders: --
5  diseases for BPIFB2: About MalaCardstonsillitis carcinoma hepatitis b nasopharyngitis
hepatitis
Export disorders for BPIFB2 gene to outside databases
|
Publications
for BPIFB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BPIFB2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with BPIFB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). (PubMed id 12185532)1, 2, 3 Mulero J.J.... Rupp F. (2002)
- Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PubMed id 21787333)1, 3 Bingle C.D....Craven C.J. (2011)
- Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. (PubMed id 12837268)1, 2 Andrault J.-B.... Rouquier S. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
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External Searches for BPIFB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing BPIFB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BPIFB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BPIFB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BPIFB2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for BPIFB2 gene:
Search GeneIP for patents involving BPIFB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BPIFB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | BPIFB2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFB2 |
|  |  |  | | | | ThermoFisher Antibody for BPIFB2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPIFB2 |
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