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Aliases for BPIFB1 Gene

Aliases for BPIFB1 Gene

  • BPI Fold Containing Family B Member 1 2 3 5
  • Von Ebner Minor Salivary Gland Protein 2 3 4
  • Long Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 1 3 4
  • C20orf114 3 4
  • LPLUNC1 3 4
  • VEMSGP 3 4
  • Long Palate, Lung And Nasal Epithelium Carcinoma Associated 1 3
  • BPI Fold Containing Family B, Member 1 3
  • Chromosome 20 Open Reading Frame 114 2

External Ids for BPIFB1 Gene

Previous HGNC Symbols for BPIFB1 Gene

  • C20orf114

Previous GeneCards Identifiers for BPIFB1 Gene

  • GC20P031864

Summaries for BPIFB1 Gene

Entrez Gene Summary for BPIFB1 Gene

  • The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]

GeneCards Summary for BPIFB1 Gene

BPIFB1 (BPI Fold Containing Family B Member 1) is a Protein Coding gene. Diseases associated with BPIFB1 include papillary cystadenocarcinoma and cholera. GO annotations related to this gene include lipid binding.

UniProtKB/Swiss-Prot for BPIFB1 Gene

  • May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFB1 Gene

Genomics for BPIFB1 Gene

Genomic Location for BPIFB1 Gene

Chromosome:
20
Start:
33,273,480 bp from pter
End:
33,309,878 bp from pter
Size:
36,399 bases
Orientation:
Plus strand

Genomic View for BPIFB1 Gene

Genes around BPIFB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFB1 Gene

No data available for Regulatory Elements for BPIFB1 Gene

Proteins for BPIFB1 Gene

  • Protein details for BPIFB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDL5-BPIB1_HUMAN
    Recommended name:
    BPI fold-containing family B member 1
    Protein Accession:
    Q8TDL5
    Secondary Accessions:
    • A8K2H8
    • Q5QP43
    • Q6UWY1
    • Q6ZRU7
    • Q96HK6
    • Q9BQP8
    • Q9BWZ6
    • Q9H4V6

    Protein attributes for BPIFB1 Gene

    Size:
    484 amino acids
    Molecular mass:
    52442 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BPIFB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BPIFB1 Gene

Proteomics data for BPIFB1 Gene at MOPED

Post-translational modifications for BPIFB1 Gene

  • Glycosylation at Asn 48, Asn 264, and Asn 401
  • Modification sites at PhosphoSitePlus

Other Protein References for BPIFB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BPIFB1 Gene

Domains & Families for BPIFB1 Gene

Gene Families for BPIFB1 Gene

Suggested Antigen Peptide Sequences for BPIFB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDL5

UniProtKB/Swiss-Prot:

BPIB1_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
genes like me logo Genes that share domains with BPIFB1: view

Function for BPIFB1 Gene

Molecular function for BPIFB1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS.
genes like me logo Genes that share phenotypes with BPIFB1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BPIFB1

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPIFB1 Gene

Localization for BPIFB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFB1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BPIFB1 Gene COMPARTMENTS Subcellular localization image for BPIFB1 gene
Compartment Confidence
extracellular 5
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BPIFB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 20237794
genes like me logo Genes that share ontologies with BPIFB1: view

Pathways & Interactions for BPIFB1 Gene

SuperPathways for BPIFB1 Gene

No Data Available

Interacting Proteins for BPIFB1 Gene

Gene Ontology (GO) - Biological Process for BPIFB1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BPIFB1 Gene

Drugs & Compounds for BPIFB1 Gene

No Compound Related Data Available

Transcripts for BPIFB1 Gene

mRNA/cDNA for BPIFB1 Gene

Unigene Clusters for BPIFB1 Gene

BPI fold containing family B, member 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFB1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^
SP1: - - - -
SP2: -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9: - - -
SP10: -
SP11: - - - -
SP12: -
SP13: - - - - - - - - - - - - - - - - - -

ExUns: 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - -

Relevant External Links for BPIFB1 Gene

GeneLoc Exon Structure for
BPIFB1
ECgene alternative splicing isoforms for
BPIFB1

Expression for BPIFB1 Gene

mRNA expression in normal human tissues for BPIFB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BPIFB1 Gene

This gene is overexpressed in Cervix - Endocervix (x18.2), Esophagus - Mucosa (x10.7), Lung (x9.9), and Minor Salivary Gland (x8.3).

Protein differential expression in normal tissues from HIPED for BPIFB1 Gene

This gene is overexpressed in Nasal epithelium (14.9), Saliva (13.9), Cervix (12.8), and Lavage (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFB1 Gene



SOURCE GeneReport for Unigene cluster for BPIFB1 Gene Hs.65551

mRNA Expression by UniProt/SwissProt for BPIFB1 Gene

Q8TDL5-BPIB1_HUMAN
Tissue specificity: Detected in duodenum mucosal crypts of cholera patients, near Paneth cells (at protein level). Detected in trachea, nasal septal epithelium and lung.
genes like me logo Genes that share expression patterns with BPIFB1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for BPIFB1 Gene

Orthologs for BPIFB1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BPIFB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPIFB1 35
  • 97.73 (n)
  • 96.16 (a)
BPIFB1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BPIFB1 36
  • 57 (a)
OneToOne
BPIFB1 35
  • 74.36 (n)
  • 56.99 (a)
dog
(Canis familiaris)
Mammalia BPIFB1 35
  • 81.72 (n)
  • 71.1 (a)
BPIFB1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bpifb1 36
  • 59 (a)
OneToOne
Bpifb1 16
Bpifb1 35
  • 72.09 (n)
  • 59.62 (a)
oppossum
(Monodelphis domestica)
Mammalia BPIFB1 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BPIFB1 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bpifb1 35
  • 71.42 (n)
  • 57.45 (a)
Species with no ortholog for BPIFB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFB1 Gene

ENSEMBL:
Gene Tree for BPIFB1 (if available)
TreeFam:
Gene Tree for BPIFB1 (if available)

Paralogs for BPIFB1 Gene

No data available for Paralogs for BPIFB1 Gene

Variants for BPIFB1 Gene

Sequence variations from dbSNP and Humsavar for BPIFB1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1078761 - 33,288,875(+) AGCAC(A/C/G)TCATC reference, missense
rs1999663 - 33,309,748(+) ACCCA(C/G)CTCTC reference, missense
rs6120221 - 33,301,377(+) TGCTC(C/T)CTCCA reference, missense
rs6120222 - 33,302,369(+) TGAGA(G/T)TGCCC reference, missense
rs34578060 - 33,291,009(-) GATGG(C/T)GGCTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for BPIFB1 Gene

Variant ID Type Subtype PubMed ID
nsv518678 CNV Loss 19592680

Variation tolerance for BPIFB1 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.78; 73.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BPIFB1 Gene

HapMap Linkage Disequilibrium report
BPIFB1
Human Gene Mutation Database (HGMD)
BPIFB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFB1 Gene

Disorders for BPIFB1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for BPIFB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
papillary cystadenocarcinoma
  • papillary cystadenocarcinoma, nos
cholera
  • cholera - vibrio cholerae
nasopharynx carcinoma
  • nasopharyngeal carcinoma
pharynx cancer
  • pharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BPIFB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPIFB1
genes like me logo Genes that share disorders with BPIFB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BPIFB1 Gene

Publications for BPIFB1 Gene

  1. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PMID: 11971875) Bingle C.D. … Craven C.J. (Hum. Mol. Genet. 2002) 2 3 4 67
  2. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle C.D. … Craven C.J. (Biochem. Soc. Trans. 2011) 2 3
  3. Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts. (PMID: 20237794) Bingle C.D. … Bingle L. (Histochem. Cell Biol. 2010) 3 23
  4. Identification of tissue-specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray. (PMID: 12874788) Zhang B. … Li G. (Genes Chromosomes Cancer 2003) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for BPIFB1 Gene

Sources for BPIFB1 Gene

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