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Aliases for BPIFA3 Gene

Aliases for BPIFA3 Gene

  • BPI Fold Containing Family A Member 3 2 3 5
  • C20orf71 3 4
  • SPLUNC3 3 4
  • Short Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 3 4
  • Short Long Palate, Lung And Nasal Epithelium Carcinoma Associated 3 3
  • BPI Fold Containing Family A, Member 3 3
  • Chromosome 20 Open Reading Frame 71 2

External Ids for BPIFA3 Gene

Previous HGNC Symbols for BPIFA3 Gene

  • C20orf71

Previous GeneCards Identifiers for BPIFA3 Gene

  • GC20P031806

Summaries for BPIFA3 Gene

GeneCards Summary for BPIFA3 Gene

BPIFA3 (BPI Fold Containing Family A Member 3) is a Protein Coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFA1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFA3 Gene

Genomics for BPIFA3 Gene

Genomic Location for BPIFA3 Gene

Chromosome:
20
Start:
33,217,310 bp from pter
End:
33,227,806 bp from pter
Size:
10,497 bases
Orientation:
Plus strand

Genomic View for BPIFA3 Gene

Genes around BPIFA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFA3 Gene

No data available for Regulatory Elements for BPIFA3 Gene

Proteins for BPIFA3 Gene

  • Protein details for BPIFA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQP9-BPIA3_HUMAN
    Recommended name:
    BPI fold-containing family A member 3
    Protein Accession:
    Q9BQP9
    Secondary Accessions:
    • Q5JWG8
    • Q6NZ38

    Protein attributes for BPIFA3 Gene

    Size:
    254 amino acids
    Molecular mass:
    28436 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BPIFA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BPIFA3 Gene

Proteomics data for BPIFA3 Gene at MOPED

Post-translational modifications for BPIFA3 Gene

No Post-translational modifications

Other Protein References for BPIFA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFA3 Gene

Domains & Families for BPIFA3 Gene

Gene Families for BPIFA3 Gene

Protein Domains for BPIFA3 Gene

Suggested Antigen Peptide Sequences for BPIFA3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQP9

UniProtKB/Swiss-Prot:

BPIA3_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
genes like me logo Genes that share domains with BPIFA3: view

Function for BPIFA3 Gene

genes like me logo Genes that share phenotypes with BPIFA3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPIFA3 Gene

Localization for BPIFA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFA3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BPIFA3 Gene COMPARTMENTS Subcellular localization image for BPIFA3 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for BPIFA3 Gene

Pathways & Interactions for BPIFA3 Gene

SuperPathways for BPIFA3 Gene

No Data Available

Interacting Proteins for BPIFA3 Gene

Gene Ontology (GO) - Biological Process for BPIFA3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BPIFA3 Gene

Drugs & Compounds for BPIFA3 Gene

No Compound Related Data Available

Transcripts for BPIFA3 Gene

mRNA/cDNA for BPIFA3 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BPIFA3 Gene

BPI fold containing family A, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFA3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1:
SP2: - -
SP3: -

Relevant External Links for BPIFA3 Gene

GeneLoc Exon Structure for
BPIFA3
ECgene alternative splicing isoforms for
BPIFA3

Expression for BPIFA3 Gene

mRNA expression in normal human tissues for BPIFA3 Gene

mRNA differential expression in normal tissues according to GTEx for BPIFA3 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for BPIFA3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BPIFA3 Gene



SOURCE GeneReport for Unigene cluster for BPIFA3 Gene Hs.360989

genes like me logo Genes that share expression patterns with BPIFA3: view

Protein tissue co-expression partners for BPIFA3 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BPIFA3 Gene

Orthologs for BPIFA3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BPIFA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BPIFA3 35
  • 80.91 (n)
  • 67.09 (a)
C13H20ORF71 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BPIFA3 35
  • 80.77 (n)
  • 67.52 (a)
BPIFA3 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bpifa3 35
  • 77.2 (n)
  • 66.51 (a)
Bpifa3 16
Bpifa3 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BPIFA3 35
  • 98.93 (n)
  • 97.2 (a)
BPIFA3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bpifa3 35
  • 77.02 (n)
  • 67.48 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia BPIFA3 36
  • 19 (a)
OneToOne
Species with no ortholog for BPIFA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFA3 Gene

ENSEMBL:
Gene Tree for BPIFA3 (if available)
TreeFam:
Gene Tree for BPIFA3 (if available)

Paralogs for BPIFA3 Gene

Paralogs for BPIFA3 Gene

genes like me logo Genes that share paralogs with BPIFA3: view

Variants for BPIFA3 Gene

Sequence variations from dbSNP and Humsavar for BPIFA3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs17124391 - 33,217,658(+) CCTGG(A/C)AAGAA nc-transcript-variant, reference, missense
rs3818222 - 33,225,117(+) ACATC(A/G)TAAAG nc-transcript-variant, reference, missense
rs1007470 -- 33,224,503(+) GCCCT(C/G)CTCGC intron-variant
rs1321416 -- 33,228,112(+) gtgac(A/C/G)catga downstream-variant-500B
rs1321417 -- 33,228,167(+) AATAT(C/T)TGTGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for BPIFA3 Gene

Variant ID Type Subtype PubMed ID
nsv458964 CNV Loss 19166990
esv2751912 CNV Loss 17911159
esv2145221 CNV Deletion 18987734

Variation tolerance for BPIFA3 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.42; 63.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BPIFA3 Gene

HapMap Linkage Disequilibrium report
BPIFA3
Human Gene Mutation Database (HGMD)
BPIFA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFA3 Gene

Disorders for BPIFA3 Gene

Relevant External Links for BPIFA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPIFA3

No disorders were found for BPIFA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFA3 Gene

Publications for BPIFA3 Gene

  1. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PMID: 21787333) Bingle C.D. … Craven C.J. (Biochem. Soc. Trans. 2011) 2 3 67
  2. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PMID: 11971875) Bingle C.D. … Craven C.J. (Hum. Mol. Genet. 2002) 2 3
  3. Phylogenetic and evolutionary analysis of the PLUNC gene family. (PMID: 14739326) Bingle C.D. … Craven C.J. (Protein Sci. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3

Products for BPIFA3 Gene

Sources for BPIFA3 Gene

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