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Aliases for BPIFA2 Gene

Aliases for BPIFA2 Gene

  • BPI Fold Containing Family A, Member 2 2 3
  • Short Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 2 3 4
  • Parotid Secretory Protein 3 4
  • C20orf70 3 4
  • SPLUNC2 3 4
  • PSP 3 4
  • Short Palate, Lung And Nasal Epithelium Carcinoma Associated 2 3
  • Chromosome 20 Open Reading Frame 70 2
  • BA49G10.1 3

External Ids for BPIFA2 Gene

Previous HGNC Symbols for BPIFA2 Gene

  • C20orf70

Previous GeneCards Identifiers for BPIFA2 Gene

  • GC20P031750

Summaries for BPIFA2 Gene

GeneCards Summary for BPIFA2 Gene

BPIFA2 (BPI Fold Containing Family A, Member 2) is a Protein Coding gene. Diseases associated with BPIFA2 include lacrimal apparatus disease. GO annotations related to this gene include lipid binding and lipopolysaccharide binding.

UniProtKB/Swiss-Prot for BPIFA2 Gene

  • Has strong antibacterial activity against P. aeruginosa.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFA2 Gene

Genomics for BPIFA2 Gene

Genomic Location for BPIFA2 Gene

Chromosome:
20
Start:
33,161,768 bp from pter
End:
33,181,417 bp from pter
Size:
19,650 bases
Orientation:
Plus strand

Genomic View for BPIFA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BPIFA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFA2 Gene

No data available for Regulatory Elements for BPIFA2 Gene

Proteins for BPIFA2 Gene

  • Protein details for BPIFA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DR5-BPIA2_HUMAN
    Recommended name:
    BPI fold-containing family A member 2
    Protein Accession:
    Q96DR5
    Secondary Accessions:
    • Q9BQQ0

    Protein attributes for BPIFA2 Gene

    Size:
    249 amino acids
    Molecular mass:
    27011 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFA2 Gene

Proteomics data for BPIFA2 Gene at MOPED

Post-translational modifications for BPIFA2 Gene

  • Glycosylation at Asn 124 and Asn 132

Other Protein References for BPIFA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BPIFA2 Gene

Domains & Families for BPIFA2 Gene

Gene Families for BPIFA2 Gene

Protein Domains for BPIFA2 Gene

Suggested Antigen Peptide Sequences for BPIFA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DR5

UniProtKB/Swiss-Prot:

BPIA2_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
genes like me logo Genes that share domains with BPIFA2: view

Function for BPIFA2 Gene

Molecular function for BPIFA2 Gene

UniProtKB/Swiss-Prot Function:
Has strong antibacterial activity against P. aeruginosa.

Gene Ontology (GO) - Molecular Function for BPIFA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 21833535
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding --
genes like me logo Genes that share ontologies with BPIFA2: view

Phenotypes for BPIFA2 Gene

GenomeRNAi human phenotypes for BPIFA2:
genes like me logo Genes that share phenotypes with BPIFA2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPIFA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BPIFA2 Gene

Localization for BPIFA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BPIFA2 Gene COMPARTMENTS Subcellular localization image for BPIFA2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for BPIFA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 19499239
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with BPIFA2: view

Pathways & Interactions for BPIFA2 Gene

SuperPathways for BPIFA2 Gene

No Data Available

Interacting Proteins for BPIFA2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000253362%0d%0a9606.ENSP00000319713%0d%0a
Selected Interacting proteins: ENSP00000253362 Q96DR5-BPIA2_HUMAN for BPIFA2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for BPIFA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with BPIFA2: view

No data available for Pathways by source and SIGNOR curated interactions for BPIFA2 Gene

Drugs & Compounds for BPIFA2 Gene

No Compound Related Data Available

Transcripts for BPIFA2 Gene

mRNA/cDNA for BPIFA2 Gene

Unigene Clusters for BPIFA2 Gene

BPI fold containing family A, member 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPIFA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFA2 Gene

No ASD Table

Relevant External Links for BPIFA2 Gene

GeneLoc Exon Structure for
BPIFA2
ECgene alternative splicing isoforms for
BPIFA2

Expression for BPIFA2 Gene

mRNA expression in normal human tissues for BPIFA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BPIFA2 Gene

This gene is overexpressed in Testis (x21.7), Kidney - Cortex (x6.9), Thyroid (x5.3), and Esophagus - Muscularis (x4.3).

Protein differential expression in normal tissues from HIPED for BPIFA2 Gene

This gene is overexpressed in Skin (46.9) and Salivary gland (19.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BPIFA2 Gene



SOURCE GeneReport for Unigene cluster for BPIFA2 Gene Hs.125960

mRNA Expression by UniProt/SwissProt for BPIFA2 Gene

Q96DR5-BPIA2_HUMAN
Tissue specificity: Detected in submandibular gland. Secreted into saliva.
genes like me logo Genes that share expression patterns with BPIFA2: view

Protein tissue co-expression partners for BPIFA2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for BPIFA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BPIFA2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia BPIFA2 35
  • 71.07 (n)
  • 53.31 (a)
BPIFA2 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bpifa2 35
  • 57.55 (n)
  • 37.22 (a)
Bpifa2 16
Bpifa2 36
  • 33 (a)
OneToMany
Gm21718 36
  • 27 (a)
OneToMany
Gm21850 36
  • 27 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia BPIFA2 35
  • 98.66 (n)
  • 99.2 (a)
BPIFA2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bpifa2 35
  • 57.01 (n)
  • 33.94 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 40 (a)
OneToMany
BPIFA2B 36
  • 39 (a)
OneToMany
BSP30C 36
  • 31 (a)
OneToMany
BSP30D 36
  • 35 (a)
OneToMany
Species with no ortholog for BPIFA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFA2 Gene

ENSEMBL:
Gene Tree for BPIFA2 (if available)
TreeFam:
Gene Tree for BPIFA2 (if available)

Paralogs for BPIFA2 Gene

No data available for Paralogs for BPIFA2 Gene

Variants for BPIFA2 Gene

Sequence variations from dbSNP and Humsavar for BPIFA2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs747136 -- 33,180,339(-) TACCT(G/T)CCCCA intron-variant
rs747137 -- 33,180,234(-) TCTTT(C/T)TTTTT intron-variant
rs1075435 -- 33,179,664(+) AGGTC(A/C/G)TCGGT missense, reference
rs1075436 -- 33,179,702(+) GAGGC(A/G)GGCAT intron-variant
rs1321425 -- 33,174,946(+) AGATA(C/G)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFA2 Gene

Variant ID Type Subtype PubMed ID
nsv458964 CNV Loss 19166990
esv2751912 CNV Loss 17911159

Variation tolerance for BPIFA2 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BPIFA2 Gene

HapMap Linkage Disequilibrium report
BPIFA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFA2 Gene

Disorders for BPIFA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BPIFA2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lacrimal apparatus disease
  • lacrimal apparatus diseases
- elite association

Relevant External Links for BPIFA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPIFA2
genes like me logo Genes that share disorders with BPIFA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BPIFA2 Gene

Publications for BPIFA2 Gene

  1. Design and validation of anti-inflammatory peptides from human parotid secretory protein. (PMID: 15668332) Geetha C. … Gorr S.U. (J. Dent. Res. 2005) 23 67
  2. Expression and anti-bacterial activity of human parotid secretory protein (PSP). (PMID: 12887312) Geetha C. … Gorr S.U. (Biochem. Soc. Trans. 2003) 23 67
  3. The BSP30 salivary proteins from cattle, LUNX/PLUNC and von Ebner's minor salivary gland protein are members of the PSP/LBP superfamily of proteins. (PMID: 12427544) Wheeler T.T. … Grigor M.R. (Biochim. Biophys. Acta 2002) 23 67
  4. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PMID: 11971875) Bingle C.D. … Craven C.J. (Hum. Mol. Genet. 2002) 2 67
  5. A cassette for high-level expression in the mouse salivary glands. (PMID: 9370303) Laursen J. … Hjorth J.P. (Gene 1997) 23 67

Products for BPIFA2 Gene

Sources for BPIFA2 Gene

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