BPIFA2 Gene
protein-coding GIFtS: 40
GCID: GC20P031750
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BPI fold containing family A, member 2(Previous name: chromosome 20 open reading frame 70 )
(Previous symbol: C20orf70)
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Aliases
for BPIFA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BPI Fold Containing Family A, Member 21 2 | | Parotid Secretory Protein2 3 | | C20orf701 2 3 | | Short Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 22 3 | | PSP1 2 3 | | Chromosome 20 Open Reading Frame 701 | | SPLUNC21 2 3 | | BPI Fold-Containing Family A Member 22 | | BA49G10.11 | | Short Palate, Lung And Nasal Epithelium Carcinoma Associated 22 |
Export aliases for BPIFA2 gene to outside databases |
Summaries
for BPIFA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for BPIFA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for BPIFA2
Other transcription factors
Search SABiosciences Chromatin IP Primers for BPIFA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BPIFA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.21BPIFA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P031750: view genomic region
(about GC identifiers)
Start:
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31,749,574 bp from pter |
End:
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31,769,223 bp from pter |
Size:
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19,650 bases |
Orientation:
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plus strand |
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Proteins
for BPIFA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BPIA2_HUMAN, Q96DR5 (See
protein sequence)Recommended Name: BPI fold-containing family A member 2 precursor Size: 249 amino acids; 27011 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: Q9BQQ0Explore the universe of human proteins at neXtProt for BPIFA2: NX_Q96DR5
BPIFA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_542141.1
ENSEMBL proteins: ENSP00000253362 ENSP00000347012
Human Recombinant Protein Products for BPIFA2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
BPIFA2 for ontologies About GeneDecksing
BPIFA2 Antibody Products:
Assay Products for BPIFA2: |
Protein
Domains /
Families
for BPIFA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BPIFA2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96DR5ProtoNet protein and cluster: Q96DR5 UniProtKB/Swiss-Prot: BPIA2_HUMAN, Q96DR5Similarity: Belongs to the BPI/LBP/Plunc superfamily. Plunc family |
Function
for BPIFA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008289 | lipid binding |
IEA | -- |
BPIFA2 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for BPIFA2:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFA2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for BPIFA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPIFA2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFA2 |
|
Pathways & Interactions
for BPIFA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BPIFA2
|
Drugs & Compounds
for BPIFA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BPIFA2
Search CenterWatch for drugs/clinical trials and news about BPIFA2 / BPIA2
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Transcripts
for BPIFA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BPIFA2 gene: NM_080574.2 Unigene Cluster for BPIFA2: BPI fold containing family A, member 2 Hs.125960 [show with all ESTs]Unigene Representative Sequence: AK2918542 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000253362 ENST00000354932(uc002wyo.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFA2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFA2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for BPIFA2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BPIFA2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPIFA2 |
Additional cDNA sequence: AF432917.1 AK291854.1 AY359055.1 BC065726.1 4 DOTS entries: DT.100670702 DT.100798293 DT.100798295 DT.65287480 24/63 AceView cDNA sequences (see all 63): AK130550 CA311567 AI002928 BX279895 BX484489 BC065726 CB959442 AA693448 NM_080574 AF432917 CB985761 BX485066 CB956408 CB985333 CB986542 BX487606 CB986486 CB957423 BX485187 CB955995 AY359055 CB956014 CB985631 CB959287
GeneLoc Exon Structure
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Expression
for BPIFA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BPIFA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGATTGGTT
About this image
See BPIFA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BPIFA2
SOURCE GeneReport for Unigene cluster: Hs.125960
UniProtKB/Swiss-Prot: BPIA2_HUMAN, Q96DR5Tissue specificity: Detected in submandibular gland
SABiosciences Custom PCR Arrays for BPIFA2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BPIFA2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat BPIFA2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BPIFA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BPIFA2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFA2 |
Orthologs
for BPIFA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for BPIFA2 gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for BPIFA2 (if available)
TreeFam Gene Tree for BPIFA2 (if available) |
Paralogs
for BPIFA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for BPIFA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BPIFA2 (31749574 - 31769223 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BPIFA2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BPIFA2 |
|
Disorders
/ Diseases
for BPIFA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BPIFA2 for disorders About GeneDecksing
1  disease for BPIFA2: About MalaCardscarcinoma
Export disorders for BPIFA2 gene to outside databases
|
Publications
for BPIFA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BPIFA2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with BPIFA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PubMed id 11971875)1, 2, 3 Bingle C.D. and Craven C.J. (2002)
- Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Human parotid secretory protein is a lipopolysacchari de-binding protein: identification of an anti-inflammatory peptide domain. (PubMed id 21833535)1 Abdolhosseini M....Gorr S.U. (2012)
- Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PubMed id 21787333)1 Bingle C.D....Craven C.J. (2011)
- Characterisation and expression of SPLUNC2, the human orthologue of rodent parotid secretory protein. (PubMed id 19499239)1 Bingle L....Bingle C.D. (2009)
- Expression of PLUNC family members in benign and malignant salivary gland tumours. (PubMed id 18221458)1 Vargas P.A....Bingle L. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
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External Searches for BPIFA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing BPIFA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BPIFA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BPIFA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BPIFA2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for BPIFA2 gene:
Search GeneIP for patents involving BPIFA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BPIFA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BPIFA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BPIFA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BPIFA2 | | | OriGene Protein Over-expression Lysate for BPIFA2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BPIFA2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPIFA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |  |  |  | |
| | | | Search Tocris compounds for BPIFA2 |
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 | | | BPIFA2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPIFA2 |
|  |  |  |  | | | | ThermoFisher Antibodies for BPIFA2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPIFA2 |
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