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Aliases for BPIFA2 Gene

Aliases for BPIFA2 Gene

  • BPI Fold Containing Family A, Member 2 2 3
  • Short Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 2 3 4
  • Parotid Secretory Protein 3 4
  • C20orf70 3 4
  • SPLUNC2 3 4
  • PSP 3 4
  • Short Palate, Lung And Nasal Epithelium Carcinoma Associated 2 3
  • BPI Fold-Containing Family A Member 2 3
  • Chromosome 20 Open Reading Frame 70 2
  • BA49G10.1 3

External Ids for BPIFA2 Gene

Previous HGNC Symbols for BPIFA2 Gene

  • C20orf70

Previous GeneCards Identifiers for BPIFA2 Gene

  • GC20P031750

Summaries for BPIFA2 Gene

GeneCards Summary for BPIFA2 Gene

BPIFA2 (BPI Fold Containing Family A, Member 2) is a Protein Coding gene. GO annotations related to this gene include lipid binding.

UniProtKB/Swiss-Prot for BPIFA2 Gene

  • Has strong antibacterial activity against P. aeruginosa.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFA2 Gene

Genomics for BPIFA2 Gene

Genomic Location for BPIFA2 Gene

Start:
33,161,768 bp from pter
End:
33,181,417 bp from pter
Size:
19,650 bases
Orientation:
Plus strand

Genomic View for BPIFA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BPIFA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFA2 Gene

No data available for Regulatory Elements for BPIFA2 Gene

Proteins for BPIFA2 Gene

  • Protein details for BPIFA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DR5-BPIA2_HUMAN
    Recommended name:
    BPI fold-containing family A member 2
    Protein Accession:
    Q96DR5
    Secondary Accessions:
    • Q9BQQ0

    Protein attributes for BPIFA2 Gene

    Size:
    249 amino acids
    Molecular mass:
    27011 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BPIFA2 Gene

Proteomics data for BPIFA2 Gene at MOPED

Post-translational modifications for BPIFA2 Gene

  • Glycosylation at Asn124 and Asn132

Other Protein References for BPIFA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPIFA2 Gene

Domains for BPIFA2 Gene

Gene Families for BPIFA2 Gene

HGNC:
  • BPIF :BPI fold containing

Protein Domains for BPIFA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DR5

UniProtKB/Swiss-Prot:

BPIA2_HUMAN :
  • Q96DR5
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
genes like me logo Genes that share domains with BPIFA2: view

No data available for Suggested Antigen Peptide Sequences for BPIFA2 Gene

Function for BPIFA2 Gene

Molecular function for BPIFA2 Gene

UniProtKB/Swiss-Prot Function: Has strong antibacterial activity against P. aeruginosa.

Gene Ontology (GO) - Molecular Function for BPIFA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 21833535
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding --
genes like me logo Genes that share ontologies with BPIFA2: view

Phenotypes for BPIFA2 Gene

GenomeRNAi human phenotypes for BPIFA2:
genes like me logo Genes that share phenotypes with BPIFA2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPIFA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BPIFA2 Gene

Localization for BPIFA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFA2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for BPIFA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 19499239
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with BPIFA2: view

No data available for Subcellular locations from COMPARTMENTS for BPIFA2 Gene

Pathways for BPIFA2 Gene

SuperPathways for BPIFA2 Gene

No Data Available

Interacting Proteins for BPIFA2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000253362%0d%0a9606.ENSP00000319713%0d%0a
Selected Interacting proteins: ENSP00000253362 Q96DR5-BPIA2_HUMAN for BPIFA2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for BPIFA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with BPIFA2: view

No data available for Pathways by source for BPIFA2 Gene

Transcripts for BPIFA2 Gene

mRNA/cDNA for BPIFA2 Gene

Unigene Clusters for BPIFA2 Gene

BPI fold containing family A, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPIFA2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BPIFA2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFA2 Gene

No ASD Table

Relevant External Links for BPIFA2 Gene

GeneLoc Exon Structure for
BPIFA2
ECgene alternative splicing isoforms for
BPIFA2

Expression for BPIFA2 Gene

mRNA expression in normal human tissues for BPIFA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BPIFA2 Gene

This gene is overexpressed in Testis (21.7), Kidney - Cortex (6.9), Thyroid (5.3), and Esophagus - Muscularis (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BPIFA2 Gene

SOURCE GeneReport for Unigene cluster for BPIFA2 Gene Hs.125960

mRNA Expression by UniProt/SwissProt for BPIFA2 Gene

Q96DR5-BPIA2_HUMAN
Tissue specificity: Detected in submandibular gland. Secreted into saliva.
genes like me logo Genes that share expressions with BPIFA2: view

In Situ Assay Products

Orthologs for BPIFA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BPIFA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPIFA2 35
  • 98.66 (n)
  • 99.2 (a)
BPIFA2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 40 (a)
OneToMany
BPIFA2B 36
  • 39 (a)
OneToMany
BSP30C 36
  • 31 (a)
OneToMany
BSP30D 36
  • 35 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BPIFA2 35
  • 71.07 (n)
  • 53.31 (a)
BPIFA2 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bpifa2 35
  • 57.55 (n)
  • 37.22 (a)
Bpifa2 16
Bpifa2 36
  • 33 (a)
OneToMany
Gm21718 36
  • 27 (a)
OneToMany
Gm21850 36
  • 27 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Bpifa2 35
  • 57.01 (n)
  • 33.94 (a)
Species with no ortholog for BPIFA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFA2 Gene

ENSEMBL:
Gene Tree for BPIFA2 (if available)
TreeFam:
Gene Tree for BPIFA2 (if available)

Paralogs for BPIFA2 Gene

No data available for Paralogs for BPIFA2 Gene

Variants for BPIFA2 Gene

Sequence variations from dbSNP and Humsavar for BPIFA2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs747136 -- 33,180,339(-) TACCT(G/T)CCCCA intron-variant
rs747137 -- 33,180,234(-) TCTTT(C/T)TTTTT intron-variant
rs987248 -- 33,160,716(+) CCTCC(A/C)CCAAC upstream-variant-2KB
rs1075435 -- 33,179,664(+) AGGTC(A/C/G)TCGGT missense, reference
rs1075436 -- 33,179,702(+) GAGGC(A/G)GGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFA2 Gene

Variant ID Type Subtype PubMed ID
nsv458964 CNV Loss 19166990
esv2751912 CNV Loss 17911159

Relevant External Links for BPIFA2 Gene

HapMap Linkage Disequilibrium report
BPIFA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFA2 Gene

Disorders for BPIFA2 Gene

No disorders were found for BPIFA2 Gene.

No data available for UniProtKB/Swiss-Prot for BPIFA2 Gene

Publications for BPIFA2 Gene

  1. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. (PMID: 11971875) Bingle C.D. … Craven C.J. (Hum. Mol. Genet. 2002) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P. … Loo J.A. (J. Proteome Res. 2006) 3 4

Products for BPIFA2 Gene

  • antibodies-online proteins for BPIFA2
  • antibodies-online antibodies for BPIFA2
  • antibodies-online kits for BPIFA2

Sources for BPIFA2 Gene

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