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BPIFA1 Gene

protein-coding   GIFtS: 48
GCID: GC20P031825

BPI Fold Containing Family A, Member 1

(Previous names: palate, lung and nasal epithelium carcinoma associated,...)
(Previous symbol: PLUNC)
  See BPIFA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BPI Fold Containing Family A, Member 11 2     Von Ebner Protein Hl2 3
PLUNC1 2 3 5     LUNX2 3
SPLUNC12 3 5     NASG2 3
Palate, Lung And Nasal Epithelium Associated1 2     SPURT2 3
Lung-Specific Protein X2 3     Palate, Lung And Nasal Epithelium Carcinoma Associated1
Nasopharyngeal Carcinoma-Related Protein2 3     bA49G10.52
Palate Lung And Nasal Epithelium Clone Protein2 3     BPI Fold-Containing Family A Member 12
Secretory Protein In Upper Respiratory Tracts2 3     Ligand-Binding Protein RYA32
Short PLUNC12 3     Protein Plunc2
Tracheal Epithelium-Enriched Protein2 3     Tracheal Epithelium Enriched Protein2

External Ids:    HGNC: 157491   Entrez Gene: 512972   Ensembl: ENSG000001981837   OMIM: 6074125   UniProtKB: Q9NP553   

Export aliases for BPIFA1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BPIFA1 Gene:
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper
airways and nasopharyngeal regions. The exact biological function of this gene is not known, however, it has been
suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a
potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript
variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only
three are known. (provided by RefSeq, Aug 2011)

GeneCards Summary for BPIFA1 Gene:
BPIFA1 (BPI fold containing family A, member 1) is a protein-coding gene. Diseases associated with BPIFA1 include patent ductus arteriosus, and lung cancer. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFA3.

UniProtKB/Swiss-Prot: BPIA1_HUMAN, Q9NP55
Function: Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in
secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such
as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic
cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby
contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway
inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated
with tumor progression

Gene Wiki entry for BPIFA1 (Plunc) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for BPIFA1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBPIFA1 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BPIFA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

BPIFA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BPIFA1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P031825:  view genomic region     (about GC identifiers)

Start:
31,823,801 bp from pter      End:
31,831,115 bp from pter
Size:
7,315 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BPIA1_HUMAN, Q9NP55 (See protein sequence)
Recommended Name: BPI fold-containing family A member 1 precursor  
Size: 256 amino acids; 26713 Da
Subunit: Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium
channel (ENaC); this inhibits proteolytic activation of ENaC
2 PDB 3D structures from and Proteopedia for BPIFA1:
4KGH (3D)        4KGO (3D)    
Secondary accessions: A8K9R3 E1P5M9 Q9NZT0

Explore the universe of human proteins at neXtProt for BPIFA1: NX_Q9NP55

Explore proteomics data for BPIFA1 at MOPED

Post-translational modifications: 

  • May be N-glycosylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BPIFA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230122.1  NP_057667.1  NP_570913.1  

    ENSEMBL proteins: 
     ENSP00000364562   ENSP00000346251   ENSP00000364571  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BPIF: BPI fold containing

    2 InterPro protein domains:
     IPR017942 Lipid-bd_serum_glycop_N
     IPR017943 Bactericidal_perm-incr_a/b_dom

    Graphical View of Domain Structure for InterPro Entry Q9NP55

    ProtoNet protein and cluster: Q9NP55

    UniProtKB/Swiss-Prot: BPIA1_HUMAN, Q9NP55
    Similarity: Belongs to the BPI/LBP/Plunc superfamily. Plunc family


    Find genes that share domains with BPIFA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BPIA1_HUMAN, Q9NP55
    Function: Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in
    secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such
    as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic
    cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby
    contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway
    inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated
    with tumor progression
    Induction: By all-trans retinoic acid (ATRA)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008289lipid binding IEA--
         
    Find genes that share ontologies with BPIFA1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bpifa1):
     immune system  respiratory system 

    Find genes that share phenotypes with BPIFA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bpifa1tm1(KOMP)Vlcg for BPIFA1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BPIA1_HUMAN, Q9NP55: Secreted. Note=Apical side of airway epithelial cells. Detected in airway surface liquid,
    nasal mucus and sputum

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA11425234
    GO:0005615extracellular space IDA--

    Find genes that share ontologies with BPIFA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BPIFA1
    Interactions:

        Search GeneGlobe Interaction Network for BPIFA1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for BPIFA1 (Q9NP552, 3 ENSP000003462514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2873156 I2D: score=3 STRING: ENSP00000357292
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019731antibacterial humoral response IDA--
    GO:0045087innate immune response NAS11971875
    GO:0050828regulation of liquid surface tension IDA--
    GO:0050891multicellular organismal water homeostasis IDA--
    GO:1900229negative regulation of single-species biofilm formation in or on host organism IMP--

    Find genes that share ontologies with BPIFA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for BPIFA1 (BPIA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BPIFA1 gene (3 alternative transcripts): 
    NM_001243193.1  NM_016583.3  NM_130852.2  

    Unigene Cluster for BPIFA1:

    BPI fold containing family A, member 1
    Hs.211092  [show with all ESTs]
    Unigene Representative Sequence: NM_130852
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375413(uc002wyu.4) ENST00000354297(uc002wyt.4) ENST00000375422(uc002wyv.3)

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    Additional mRNA sequence: 

    AB024937.1 AF158745.1 AF172993.1 AF417256.1 AF417257.1 AF439448.1 AK292778.1 AY359020.1 
    BC012549.1 DQ846869.1 

    6 DOTS entries:

    DT.70105477  DT.100777985  DT.91963803  DT.120836661  DT.100677486  DT.120836675 

    Selected AceView cDNA sequences (see all 346):

    AF439448 AF417256 BM969176 NM_016583 BC012549 BM980253 BG570614 AF417257 
    BG546713 BU680449 CD699551 AY359020 BU683901 BU684215 AA315985 CD688934 
    AW292495 CD684650 CB321685 CD703139 BM976400 CD684999 BU684117 BM969169 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BPIFA1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
    SP1:              -                                                                     
    SP2:              -                                                     -     -         
    SP3:              -                                                     -               
    SP4:                                                                                    


    ECgene alternative splicing isoforms for BPIFA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BPIFA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCTCACCT
    BPIFA1 Expression
    About this image

    BPIFA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BPIFA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211092

    UniProtKB/Swiss-Prot: BPIA1_HUMAN, Q9NP55
    Tissue specificity: Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium.
    Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. Highest
    expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways.
    Also expressed in lung cancers and some other types of cancer

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for BPIFA1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bpifa11 , 5 BPI fold containing family A, member 11, 5 79.05(n)1
    73.91(a)1
      2 (76.15 cM)5
    188431  NM_011126.31  NP_035256.21 
     1541428805 


    ENSEMBL Gene Tree for BPIFA1 (if available)
    TreeFam Gene Tree for BPIFA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BPIFA1 gene
    BPIFA32  

    Find genes that share paralogs with BPIFA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BPIFA1 (see all 326)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61201761,2
    C,F,A,H--31821995(+) CACCAC/TCCAGA 3 -- us2k1 tfbs38Minor allele frequency- T:0.15NS EA NA CSA WA 544
    rs60591741,2
    H--31822099(+) TGGCAG/AGGTCA 3 -- us2k1 tfbs34Minor allele frequency- A:0.00NS EA 418
    rs1815675381,2
    --31822164(+) ATCCTC/TAGCCT 3 -- us2k10--------
    rs19981491,2
    C,F,A,H--31822170(+) AGCCTC/ACTCAT 3 -- us2k113Minor allele frequency- A:0.22NS EA NA WA CSA 763
    rs1870296091,2
    --31822191(+) AGAGAC/TAACAA 3 -- us2k10--------
    rs1919126851,2
    --31822203(+) ACCAAA/CCACTC 3 -- us2k10--------
    rs60591751,2
    C,H--31822205(+) CAACCA/GCTCCT 3 -- us2k14Minor allele frequency- G:0.00NS EA 408
    rs1485998181,2
    --31822217(+) AAGAAA/GATGAG 3 -- us2k10--------
    rs1431909591,2
    --31822234(+) ATATGC/GAGAGC 3 -- us2k10--------
    rs1466854061,2
    C--31822244(+) CACCTC/GGCATG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for BPIFA1 (31823801 - 31831115 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BPIFA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2751912CNV Loss17911159

    Human Gene Mutation Database (HGMD): BPIFA1
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607412    OMIM disorders: --

    2 diseases for BPIFA1:    
    About MalaCards
    patent ductus arteriosus    lung cancer


    Find genes that share disorders with BPIFA1           About GenesLikeMe

    3 Novoseek inferred disease relationships for BPIFA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nasal epithelium 90.1 15 11396972 (1), 11821380 (1), 18245229 (1), 16195890 (1) (see all 8)
    nasopharyngeal carcinoma 65.6 4 12753706 (1), 16195890 (1), 16364440 (1), 20053927 (1)
    cancer lung 24.4 1 11251963 (1)


    Export disorders for BPIFA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BPIFA1 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with BPIFA1)
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    1. Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. (PubMed id 11251963)1, 2, 3, 9 Iwao K.... Tanigami A. (Int. J. Cancer 2001)
    2. Characterization of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern. (PubMed id 11018263)1, 2, 3 Bingle C.D. and Bingle L. (Biochim. Biophys. Acta 2000)
    3. Purification and characterization of PLUNC from human tracheobronchial secretions. (PubMed id 12920053)1, 2, 9 Campos M.A....Whitney P.L. (Am. J. Respir. Cell Mol. Biol. 2004)
    4. Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. (PubMed id 24124190)1, 2 Hobbs C.A....Tarran R. (Am. J. Physiol. Lung Cell Mol. Physiol. 2013)
    5. Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. (PubMed id 24043776)1, 2 Garland A.L....Tarran R. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    6. Multifunctional role of human SPLUNC1 in Pseudomonas aeruginosa infection. (PubMed id 23132494)1, 2 Sayeed S....Di Y.P. (Infect. Immun. 2013)
    7. SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection. (PubMed id 23499554)1, 2 Liu Y....Di Y.P. (Am. J. Pathol. 2013)
    8. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. (PubMed id 21787333)1, 3 Bingle C.D....Craven C.J. (Biochem. Soc. Trans. 2011)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. PLUNC in human nasal lavage fluid: multiple isoforms that bind to lipopolysaccharide. (PubMed id 15158712)1, 2 Ghafouri B.... Lindahl M. (Biochim. Biophys. Acta 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51297 HGNC: 15749 AceView: PLUNC Ensembl:ENSG00000198183 euGenes: HUgn51297
    ECgene: BPIFA1 H-InvDB: BPIFA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BPIFA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BPIFA1 gene:
    Search GeneIP for patents involving BPIFA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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