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Aliases for BPIFA1 Gene

Aliases for BPIFA1 Gene

  • BPI Fold Containing Family A, Member 1 2 3
  • SPLUNC1 3 4 6
  • PLUNC 3 4 6
  • Palate Lung And Nasal Epithelium Clone Protein 3 4
  • Secretory Protein In Upper Respiratory Tracts 3 4
  • Palate, Lung And Nasal Epithelium Associated 2 3
  • Nasopharyngeal Carcinoma-Related Protein 3 4
  • Tracheal Epithelium-Enriched Protein 3 4
  • Lung-Specific Protein X 3 4
  • Von Ebner Protein Hl 3 4
  • Short PLUNC1 3 4
  • SPURT 3 4
  • LUNX 3 4
  • NASG 3 4
  • Palate, Lung And Nasal Epithelium Carcinoma Associated 2
  • BPI Fold-Containing Family A Member 1 3
  • Tracheal Epithelium Enriched Protein 3
  • Ligand-Binding Protein RYA3 3
  • Protein Plunc 3
  • BA49G10.5 3

External Ids for BPIFA1 Gene

Previous HGNC Symbols for BPIFA1 Gene

  • PLUNC

Previous GeneCards Identifiers for BPIFA1 Gene

  • GC20P031825

Summaries for BPIFA1 Gene

Entrez Gene Summary for BPIFA1 Gene

  • This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]

GeneCards Summary for BPIFA1 Gene

BPIFA1 (BPI Fold Containing Family A, Member 1) is a Protein Coding gene. Diseases associated with BPIFA1 include nasopharyngeal carcinoma and patent ductus arteriosus. GO annotations related to this gene include lipid binding. An important paralog of this gene is BPIFA3.

UniProtKB/Swiss-Prot for BPIFA1 Gene

  • Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.

Gene Wiki entry for BPIFA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFA1 Gene

Genomics for BPIFA1 Gene

Genomic Location for BPIFA1 Gene

Start:
33,235,995 bp from pter
End:
33,243,311 bp from pter
Size:
7,317 bases
Orientation:
Plus strand

Genomic View for BPIFA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BPIFA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFA1 Gene

No data available for Regulatory Elements for BPIFA1 Gene

Proteins for BPIFA1 Gene

  • Protein details for BPIFA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP55-BPIA1_HUMAN
    Recommended name:
    BPI fold-containing family A member 1
    Protein Accession:
    Q9NP55
    Secondary Accessions:
    • A6XMV5
    • A8K9R3
    • E1P5M9
    • Q9NZT0

    Protein attributes for BPIFA1 Gene

    Size:
    256 amino acids
    Molecular mass:
    26713 Da
    Quaternary structure:
    • Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC.

    Three dimensional structures from OCA and Proteopedia for BPIFA1 Gene

    Alternative splice isoforms for BPIFA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BPIFA1 Gene

Proteomics data for BPIFA1 Gene at MOPED

Post-translational modifications for BPIFA1 Gene

Other Protein References for BPIFA1 Gene

Antibody Products

No data available for DME Specific Peptides for BPIFA1 Gene

Domains for BPIFA1 Gene

Gene Families for BPIFA1 Gene

HGNC:
  • BPIF :BPI fold containing

Protein Domains for BPIFA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP55

UniProtKB/Swiss-Prot:

BPIA1_HUMAN :
  • Q9NP55
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
genes like me logo Genes that share domains with BPIFA1: view

No data available for Suggested Antigen Peptide Sequences for BPIFA1 Gene

Function for BPIFA1 Gene

Molecular function for BPIFA1 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.
UniProtKB/Swiss-Prot Induction: By all-trans retinoic acid (ATRA).

Gene Ontology (GO) - Molecular Function for BPIFA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with BPIFA1: view

Phenotypes for BPIFA1 Gene

genes like me logo Genes that share phenotypes with BPIFA1: view

Animal Models for BPIFA1 Gene

MGI Knock Outs for BPIFA1:

Animal Model Products

CRISPR Products

miRNA for BPIFA1 Gene

miRTarBase miRNAs that target BPIFA1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPIFA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BPIFA1 Gene

Localization for BPIFA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFA1 Gene

Secreted. Note=Apical side of airway epithelial cells. Detected in airway surface liquid, nasal mucus and sputum.

Gene Ontology (GO) - Cellular Components for BPIFA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 11425234
GO:0005615 extracellular space IDA 24124190
genes like me logo Genes that share ontologies with BPIFA1: view

No data available for Subcellular locations from COMPARTMENTS for BPIFA1 Gene

Pathways for BPIFA1 Gene

SuperPathways for BPIFA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BPIFA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019731 antibacterial humoral response IDA 23499554
GO:0045087 innate immune response NAS 11971875
GO:0050828 regulation of liquid surface tension IDA 23499554
GO:0050891 multicellular organismal water homeostasis IDA 24124190
GO:1900229 negative regulation of single-species biofilm formation in or on host organism IMP 23499554
genes like me logo Genes that share ontologies with BPIFA1: view

No data available for Pathways by source for BPIFA1 Gene

Transcripts for BPIFA1 Gene

Unigene Clusters for BPIFA1 Gene

BPI fold containing family A, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPIFA1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for BPIFA1 Gene

GeneLoc Exon Structure for
BPIFA1
ECgene alternative splicing isoforms for
BPIFA1

Expression for BPIFA1 Gene

mRNA expression in normal human tissues for BPIFA1 Gene

mRNA differential expression in normal tissues according to GTEx for BPIFA1 Gene

This gene is overexpressed in Lung (28.1) and Pituitary (19.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BPIFA1 Gene

SOURCE GeneReport for Unigene cluster for BPIFA1 Gene Hs.211092

mRNA Expression by UniProt/SwissProt for BPIFA1 Gene

Q9NP55-BPIA1_HUMAN
Tissue specificity: Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium. Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer.
genes like me logo Genes that share expressions with BPIFA1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BPIFA1 Gene

Orthologs for BPIFA1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BPIFA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPIFA1 35
  • 99.48 (n)
  • 98.97 (a)
BPIFA1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BPIFA1 35
  • 81.18 (n)
  • 73.73 (a)
BPIFA1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BPIFA1 35
  • 81.44 (n)
  • 73.73 (a)
BPIFA1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bpifa1 35
  • 79.05 (n)
  • 73.91 (a)
Bpifa1 16
Bpifa1 36
  • 65 (a)
OneToMany
Bpifa5 36
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia BPIFA1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BPIFA1 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bpifa1 35
  • 78.52 (n)
  • 72.73 (a)
Species with no ortholog for BPIFA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPIFA1 Gene

ENSEMBL:
Gene Tree for BPIFA1 (if available)
TreeFam:
Gene Tree for BPIFA1 (if available)

Paralogs for BPIFA1 Gene

Paralogs for BPIFA1 Gene

genes like me logo Genes that share paralogs with BPIFA1: view

Variants for BPIFA1 Gene

Sequence variations from dbSNP and Humsavar for BPIFA1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs750064 -- 33,235,824(-) TGGTC(A/G)ACAAG upstream-variant-2KB
rs750065 -- 33,235,081(+) GAAAG(A/C/T)GTAAA upstream-variant-2KB
rs1047595 -- 33,243,149(+) CCATT(C/T)CCTCT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1321418 -- 33,238,325(+) GAGCG(A/G)CCTGA intron-variant
rs1407018 -- 33,235,752(+) CCCAA(C/T)CTTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BPIFA1 Gene

Variant ID Type Subtype PubMed ID
esv2751912 CNV Loss 17911159

Relevant External Links for BPIFA1 Gene

HapMap Linkage Disequilibrium report
BPIFA1
Human Gene Mutation Database (HGMD)
BPIFA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFA1 Gene

Disorders for BPIFA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for BPIFA1 Gene including...

Search for BPIFA1 Gene in MalaCards »

(3) Novoseek inferred disease relationships for BPIFA1 Gene

Disease -log(P) Hits PubMed IDs
nasal epithelium 90.1 8
nasopharyngeal carcinoma 65.6 4
cancer lung 24.4 1
genes like me logo Genes that share disorders with BPIFA1: view

No data available for UniProtKB/Swiss-Prot for BPIFA1 Gene

Publications for BPIFA1 Gene

  1. Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. (PMID: 11251963) Iwao K. … Tanigami A. (Int. J. Cancer 2001) 2 3 4 23
  2. Purification and characterization of PLUNC from human tracheobronchial secretions. (PMID: 12920053) Campos M.A. … Whitney P.L. (Am. J. Respir. Cell Mol. Biol. 2004) 3 4 23
  3. Characterization of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern. (PMID: 11018263) Bingle C.D. … Bingle L. (Biochim. Biophys. Acta 2000) 2 3 4
  4. Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight. (PMID: 11425234) Lindahl M. … Tagesson C. (Electrophoresis 2001) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for BPIFA1 Gene

Sources for BPIFA1 Gene

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