Aliases for BPI Gene
External Ids for BPI Gene
Previous GeneCards Identifiers for BPI Gene
This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
GeneCards Summary for BPI Gene
BPI (Bactericidal/Permeability-Increasing Protein) is a Protein Coding gene. Diseases associated with BPI include meningococcemia and stenotrophomonas maltophilia. GO annotations related to this gene include lipopolysaccharide binding. An important paralog of this gene is LBP.
UniProtKB/Swiss-Prot for BPI Gene
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.