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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BPI Gene

protein-coding   GIFtS: 59
GCID: GC20P036888

Bactericidal/Permeability-Increasing Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bactericidal/Permeability-Increasing Protein1 2     Bactericidal Permeability-Increasing Protein2
CAP 572 3     BPI Fold Containing Family D, Member 12
BPI Fold Containing Family D1     rBPI2
Member 11     Recombinant BPI Holoprotein, RBPI2
BPIFD12     

External Ids:    HGNC: 10951   Entrez Gene: 6712   Ensembl: ENSG000001014257   OMIM: 1091955   UniProtKB: P172133   

Export aliases for BPI gene to outside databases

Previous GC identifers: GC20P036661 GC20P037571 GC20P037618 GC20P036365


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BPI Gene:
This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has
bactericidal activity on gram-negative organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for BPI Gene: 
BPI (bactericidal/permeability-increasing protein) is a protein-coding gene. Diseases associated with BPI include stenotrophomonas maltophilia, and meningococcemia. GO annotations related to this gene include Gram-negative bacterial cell surface binding and lipopolysaccharide binding. An important paralog of this gene is PLTP.

UniProtKB/Swiss-Prot: BPI_HUMAN, P17213
Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may
be explained by a strong affinity of the very basic N-terminal half for the negatively charged
lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity
against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BPI gene promoter:
         c-Fos   C/EBPbeta   Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBPI promoter sequence
   Search SABiosciences Chromatin IP Primers for BPI

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BPI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

BPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BPI gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P036888:  view genomic region     (about GC identifiers)

Start:
36,888,551 bp from pter      End:
36,965,907 bp from pter
Size:
77,357 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BPI_HUMAN, P17213 (See protein sequence)
Recommended Name: Bactericidal permeability-increasing protein precursor  
Size: 487 amino acids; 53900 Da
Subunit: Monomer. Homodimer; disulfide-linked
Subcellular location: Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear
Leukocytes (PMN) granules
2 PDB 3D structures from and Proteopedia for BPI:
1BP1 (3D)        1EWF (3D)    
Secondary accessions: B2RCY2 Q1ZZU8 Q5JRW0 Q8IW58 Q9BYZ9 Q9H1L2 Q9H1M8 Q9H203 Q9UCT4 Q9UD65

Explore the universe of human proteins at neXtProt for BPI: NX_P17213

Explore proteomics data for BPI at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17213

  • BPI Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BPI Protein Expression
    REFSEQ proteins: NP_001716.2  
    ENSEMBL proteins: 
     ENSP00000393126   ENSP00000391511   ENSP00000262865   ENSP00000409833  

    Human Recombinant Protein Products for BPI: 
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    Novus Biologicals BPI Lysate
    Sino Biological Recombinant Protein for BPI
    Sino Biological Cell Lysate for BPI 
    ProSpec Recombinant Protein for BPI
    Cloud-Clone Corp. Proteins for BPI 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--
    GO:0005887integral to plasma membrane TAS2722846

    BPI for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BPIF: BPI fold containing

    4 InterPro protein domains:
     IPR017954 Lipid-bd_serum_glycop_CS
     IPR017942 Lipid-bd_serum_glycop_N
     IPR017943 Bactericidal_perm-incr_a/b_dom
     IPR001124 Lipid-bd_serum_glycop_C

    Graphical View of Domain Structure for InterPro Entry P17213

    ProtoNet protein and cluster: P17213

    1 Blocks protein domain: IPB001124 Lipid-binding serum glycoprotein

    UniProtKB/Swiss-Prot: BPI_HUMAN, P17213
    Domain: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be
    embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and
    cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the
    N-terminal antibacterial fragment when bacteria are ingested
    Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family


    BPI for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BPI_HUMAN, P17213
    Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may
    be explained by a strong affinity of the very basic N-terminal half for the negatively charged
    lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity
    against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa

         Genatlas biochemistry entry for BPI:
    bactericidal permeability increasing protein,55kDa,released from azurophilic granules of neutrophiles,oxygen
    independent phagocytosis of Gram- bacteria

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001530lipopolysaccharide binding IDA8409400
    GO:0008289lipid binding ----
    GO:0051636Gram-negative bacterial cell surface binding ----
         
    BPI for ontologies           About GeneDecksing


    Animal Models:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPI


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BPI

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for BPI (P172133 ENSP000002628654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRSS2P074783I2D: score=1 
    PRSS1ENSP000003087204STRING: ENSP00000308720
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0032715negative regulation of interleukin-6 production IDA8409400
    GO:0032717negative regulation of interleukin-8 production IDA8409400
    GO:0032720negative regulation of tumor necrosis factor production IDA8409400
    GO:0042742defense response to bacterium IEA--

    BPI for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BPI for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BPI

    1 DrugBank Compound for BPI    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Di-Stearoyl-3-Sn-Phosphatidylcholine-- --target--17139284 17016423

    10/28 Novoseek inferred chemical compound relationships for BPI gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endotoxin 78.8 144 8143464 (5), 8704115 (5), 17675509 (4), 17678885 (4) (see all 54)
    centoxin 75.9 2 8024362 (1)
    polymyxin b 64.7 13 9169763 (1), 12803879 (1), 12920053 (1), 20074236 (1) (see all 9)
    phospholipid 42.4 13 2179269 (1), 15106612 (1), 7929350 (1), 9240454 (1) (see all 8)
    lipoteichoic acid 25.7 4 8985203 (2), 14748514 (1)
    polysulfone 23.8 3 7507806 (2), 9071715 (1)
    lipid 13.5 21 20174761 (3), 17239348 (2), 10357844 (1), 10893406 (1) (see all 12)
    glycolipid 7.23 2 9568897 (1)
    fmlp 1.85 3 8985203 (2), 7678030 (1)
    aminoglycosides 0.535 1 1406489 (1)

    Search CenterWatch for drugs/clinical trials and news about BPI

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BPI gene: 
    NM_001725.2  

    Unigene Cluster for BPI:

    Bactericidal/permeability-increasing protein
    Hs.529019  [show with all ESTs]
    Unigene Representative Sequence: NM_001725
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418004 ENST00000451435(uc002xia.1) ENST00000479646 ENST00000262865(uc002xib.2)
    ENST00000417318 ENST00000489102 ENST00000489039 ENST00000490381
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BPI

    Additional mRNA sequence: 

    AF322588.1 AK296568.1 AK315328.1 BC032230.1 BC040955.1 DQ414688.1 J04739.1 

    9 DOTS entries:

    DT.110254  DT.91724397  DT.120824611  DT.92425612  DT.95200208  DT.95341024  DT.99975128  DT.120824621 
    DT.40197082 

    24/80 AceView cDNA sequences (see all 80):

    BF899146 T28011 AW950267 BU630834 BI829649 AW467552 BC040955 BI032235 
    AI436120 BI518707 NM_001725 AA789261 BI022275 AX752831 CA427085 BI022416 
    AJ705564 BI021266 BX101070 J04739 BC032230 BM922973 AF322588 BM553276 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BPI (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b
    SP1:                                -     -                             -                                               -                     
    SP2:                                                                    -                                                                     
    SP3:                                                        -           -                                                                     
    SP4:                                                        -                                                                                 
    SP5:                                                                                                        -                                 


    ECgene alternative splicing isoforms for BPI

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BPI expression in normal human tissues (normalized intensities)      BPI embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAAAACT
    BPI Expression
    About this image


    BPI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             bone marrow   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             bone marrow   
     
     Testis (Reproductive System)
             sperm   

    See BPI Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BPI

    SOURCE GeneReport for Unigene cluster: Hs.529019

    UniProtKB/Swiss-Prot: BPI_HUMAN, P17213
    Tissue specificity: Restricted to cells of the myeloid series

        SABiosciences Expression via Pathway-Focused PCR Array including BPI: 
              Antibacterial Response in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BPI
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPI

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BPI gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bpi1 , 5 bactericidal permeablility increasing protein1, 5 68.48(n)1
    54.07(a)1
      2 (78.72 cM)5
    3295471  NM_177850.31  NP_808518.11 
     1582580945 
    chicken
    (Gallus gallus)
    Aves BPI1 bactericidal/permeability-increasing protein 61.86(n)
    50.97(a)
      419293  XM_417465.3  XP_417465.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ399912.12   -- 76.59(n)    BQ399912.1 


    ENSEMBL Gene Tree for BPI (if available)
    TreeFam Gene Tree for BPI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BPI gene
    PLTP2  BPIFC2  LBP2  
    3 SIMAP similar genes for BPI using alignment to 4 protein entries:     BPI_HUMAN (see all proteins):
    LBP    BPIFC    PLTP

    BPI for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1058 SNPs in BPI are shown (see all 1058)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1170898461,2
    C,F--36930578(+) CTGGGG/TGCTCA 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs750340771,2
    F--36930674(+) TCTGCG/ATGAAA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1891493131,2
    --36930767(+) GGCTCA/GGCCTT 1 -- us2k10--------
    rs106415271,2
    C--36930862(+) atctc-/AAT/
    ATAATAAT
    aataa
    2 -- cds10--------
    rs739055941,2
    C,F--36930898(+) AATAAA/TAAAAC 1 -- us2k11Minor allele frequency- T:0.00WA 2
    rs106861621,2
    C--36930900(+) aataa-/TAA/TAATAATAA
    AAA
    /TAATAATAATAA
    aacaa
    3 -- cds1 tfbs31NA 2
    rs1810400951,2
    --36930957(+) GATGAG/TGCATA 1 -- us2k10--------
    rs60990371,2
    H--36931075(+) TTTTAG/TAACCA 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs37611481,2
    C,H--36931209(+) ACTAGG/TGGGCT 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs1504643151,2
    --36931262(+) GCCCCA/GCCCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BPI (36888551 - 36965907 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for BPI:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2722392CNV Deletion23290073
    esv2722393CNV Deletion23290073
    esv2722394CNV Deletion23290073
    nsv817893CNV Gain17921354
    esv35121CNV Gain17911159
    essv13086CNV CNV17122850
    dgv1327e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): BPI
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for BPI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 109195    OMIM disorders: --

    20/39 diseases for BPI (see all 39):    About MalaCards
    stenotrophomonas maltophilia    meningococcemia    leukopenia    bronchiectasis
    wegener's granulomatosis    cholangitis    alpha 1-antitrypsin deficiency    reactive arthritis
    vasculitis    primary sclerosing cholangitis    arthropathy    sclerosing cholangitis
    cystic fibrosis    mastitis    morbid obesity    psoriatic arthritis
    inflammatory bowel disease    ulcerative colitis    pneumonia    diabetic retinopathy

    5 diseases from the University of Copenhagen DISEASES database for BPI:
    Bipolar disorder     Vasculitis     Cystic fibrosis     Ulcerative colitis
    Conduct disorder

    BPI for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/44 Novoseek inferred disease relationships for BPI gene (see all 44)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gram-negative bacterial infections 78.2 8 7613727 (2), 20107854 (1), 12869032 (1), 11310835 (1) (see all 7)
    nasal epithelium 62 3 12427544 (1), 14630892 (1)
    vasculitis 62 7 8603534 (1), 16610259 (1), 9404779 (1), 7813109 (1) (see all 6)
    shock endotoxic 59.2 6 7706502 (2), 8501324 (1), 1729370 (1), 8063410 (1)
    shock septic 55.4 6 14504103 (1), 7798655 (1), 8161370 (1), 10586550 (1) (see all 5)
    systemic inflammatory response syndrome 52.1 5 8745023 (2), 8648149 (1), 7538550 (1)
    sepsis 51.6 38 11089749 (4), 8648149 (3), 7508221 (3), 18241571 (2) (see all 17)
    meningococcemia 51.5 1 11445748 (1)
    colitis ulcerative 51.4 19 10521980 (4), 9930392 (3), 15626895 (2), 9155585 (2) (see all 8)
    inflammatory bowel diseases 49.5 17 9155585 (4), 15626895 (2), 8603534 (2), 20107854 (1) (see all 10)

    Genetic Association Database (GAD): BPI
    Human Genome Epidemiology (HuGE) Navigator: BPI (28 documents)

    Export disorders for BPI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BPI gene, integrated from 9 sources (see all 304):
    (articles sorted by number of sources associating them with BPI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction. (PubMed id 12521224)1, 4, 9 Hubacek J.A....Poledne R. (2002)
    2. Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS- mediated cell activation. (PubMed id 7517398)1, 2, 9 Wilde C.G.... Scott R.W. (1994)
    3. Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis. (PubMed id 11373419)1, 4, 9 Hubacek J.A....Schmitz G. (2001)
    4. Crystal structure of human BPI and two bound phospholipids at 2.4-A resolution. (PubMed id 9188532)1, 2, 9 Beamer L.J.... Eisenberg D. (1997)
    5. The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20. (PubMed id 8432532)1, 3, 9 Gray P.W....Shows T.B. (1993)
    6. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    7. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    8. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    9. Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. (PubMed id 20463618)1, 4 Abu-Maziad A....Murray J.C. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 671 HGNC: 1095 AceView: BPI Ensembl:ENSG00000101425 euGenes: HUgn671
    ECgene: BPI H-InvDB: BPI

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BPI Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BPI gene:
    Search GeneIP for patents involving BPI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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