BPI Gene
protein-coding GIFtS: 57
GCID: GC20P036888
|
|
bactericidal/permeability-increasing protein
| |
Aliases
for BPI gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Bactericidal/Permeability-Increasing Protein1 2 | | BPI Fold Containing Family D, Member 12 | | BPIFD11 2 | | RBPI1 | | CAP 572 3 | | Recombinant BPI Holoprotein, RBPI2 | | Bactericidal Permeability-Increasing Protein2 | | |
Export aliases for BPI gene to outside databasesPrevious GC identifers: GC20P036661 GC20P037571 GC20P037618 GC20P036365 |
Summaries
for BPI gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BPI:
This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and hasbactericidal activity on gram-negative organisms. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BPI_HUMAN, P17213Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may beexplained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides thatare unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagativebacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa
|
Genomic Views
for BPI gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BPI gene promoter:
c-Fos C/EBPbeta Sp1 AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for BPI
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BPI |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.23 Ensembl cytogenetic band: 20q11.23 HGNC cytogenetic band: 20q11.23BPI Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P036888: view genomic region
(about GC identifiers)
Start:
|
36,888,551 bp from pter |
End:
|
36,965,907 bp from pter |
Size:
|
77,357 bases |
Orientation:
|
plus strand |
|
Proteins
for BPI gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BPI_HUMAN, P17213 (See
protein sequence)Recommended Name: Bactericidal permeability-increasing protein precursor Size: 487 amino acids; 53900 Da
Subunit: Monomer. Homodimer; disulfide-linked
Subcellular location: Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes(PMN) granules
Sequence caution: Sequence=CAC10453.2; Type=Erroneous gene model prediction; Sequence=CAC27350.2; Type=Erroneous genemodel prediction;
2 PDB 3D structures from  and Proteopedia  for BPI:1BP1 (3D)
1EWF (3D)
Secondary accessions: B2RCY2 Q1ZZU8 Q5JRW0 Q8IW58 Q9BYZ9 Q9H1L2 Q9H1M8 Q9H203 Q9UCT4 Q9UD65Explore the universe of human proteins at neXtProt for BPI: NX_P17213
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17213
BPI Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001716.2
ENSEMBL proteins: ENSP00000393126 ENSP00000391511 ENSP00000262865 ENSP00000409833
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
BPI for ontologies About GeneDecksing
BPI Antibody Products:
Assay Products for BPI: |
Protein
Domains /
Families
for BPI gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BPI for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17213ProtoNet protein and cluster: P17213 1 Blocks protein family: IPB001124 Lipid-binding serum glycoprotein
UniProtKB/Swiss-Prot: BPI_HUMAN, P17213Domain: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may beembedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleaveBPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminalantibacterial fragment when bacteria are ingestedSimilarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family |
Function
for BPI gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BPI_HUMAN, P17213Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may beexplained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides thatare unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagativebacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa Genatlas biochemistry entry for BPI:bactericidal permeability increasing protein,55kDa,released from azurophilic granules of neutrophiles,oxygenindependent phagocytosis of Gram- bacteria
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPI (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPI
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BPI (NM_001725) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BPI | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPI |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPI |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
BPI for ontologies About GeneDecksing
|
Pathways & Interactions
for BPI gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BPI
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for BPI (P172133 ENSP000002628654) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
BPI for ontologies About GeneDecksing
|
Drugs & Compounds
for BPI gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
BPI for compounds About GeneDecksing
 Browse Tocris compounds for BPI
1 DrugBank Compound for BPI About this table
10/28 Novoseek chemical compound relationships for BPI gene (see all 28) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| endotoxin |
78.8 |
144 |
8143464 (5), 8704115 (5), 17675509 (4), 17678885 (4) (see all 54) |
| centoxin |
75.9 |
2 |
8024362 (1) |
| polymyxin b |
64.7 |
13 |
9169763 (1), 12803879 (1), 12920053 (1), 20074236 (1) (see all 9) |
| phospholipid |
42.4 |
13 |
2179269 (1), 15106612 (1), 7929350 (1), 9240454 (1) (see all 8) |
| lipoteichoic acid |
25.7 |
4 |
8985203 (2), 14748514 (1) |
| polysulfone |
23.8 |
3 |
7507806 (2), 9071715 (1) |
| lipid |
13.5 |
21 |
20174761 (3), 17239348 (2), 10357844 (1), 10893406 (1) (see all 12) |
| glycolipid |
7.23 |
2 |
9568897 (1) |
| fmlp |
1.85 |
3 |
8985203 (2), 7678030 (1) |
| aminoglycosides |
0.535 |
1 |
1406489 (1) |
Search CenterWatch for drugs/clinical trials and news about BPI
|
Transcripts
for BPI gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BPI gene: NM_001725.2 Unigene Cluster for BPI: Bactericidal/permeability-increasing protein Hs.529019 [show with all ESTs]Unigene Representative Sequence: NM_0017258 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000418004 ENST00000451435(uc002xia.1) ENST00000479646 ENST00000262865(uc002xib.2)
ENST00000417318 ENST00000489102 ENST00000489039 ENST00000490381
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPI (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPI
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BPI (NM_001725) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BPI | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPI |
Additional cDNA sequence: AF322588.1 AK296568.1 AK315328.1 BC032230.1 BC040955.1 DQ414688.1 J04739.1 9 DOTS entries: DT.110254 DT.91724397 DT.120824611 DT.92425612 DT.95200208 DT.95341024 DT.99975128 DT.120824621 DT.40197082 24/80 AceView cDNA sequences (see all 80): AW950267 BF899146 BU630834 T28011 BI829649 AW467552 BC040955 BI022275 NM_001725 BM922973 AI436120 AX752831 BI021266 AA789261 BX101070 BI032235 AJ705564 BC032230 BI022416 BM553276 AF322588 BI907942 BI518707 J04739
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BPI (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for BPI
|
Expression
for BPI gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BPI expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAAAAACT
About this image
See BPI Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BPI
SOURCE GeneReport for Unigene cluster: Hs.529019
UniProtKB/Swiss-Prot: BPI_HUMAN, P17213Tissue specificity: Restricted to cells of the myeloid series
SABiosciences Expression via Pathway-Focused PCR Array including BPI:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BPI
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BPI | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BPI | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BPI | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPI |
Orthologs
for BPI gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for BPI gene from 5/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
BPI1 |
bactericidal/permeability-increasing protein |
61.86(n)
50.97(a) |
|
419293 XM_417465.3 XP_417465.3 |
lizard
(Anolis carolinensis) |
Reptilia |
BPI6 |
-- |
46(a) |
1 → many |
GL343572.1(380262-388004) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BQ399912.12 |
-- |
76.59(n) |
|
BQ399912.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G049706AT3G202706 |
lipid-binding serum glycoprotein-like protein |
22(a)14(a) |
many ↔ manymany ↔ many |
1(1411170-1413627) 3(7067057-7070946) |
rice
(Oryza sativa) |
Liliopsida |
---- |
BPI/LBP family protein At3g20270 precursor, putati...BPI/LBP family protein At3g20270 precursor, putati... |
20(a)18(a) |
many ↔ manymany ↔ many |
9(18568418-18573040) 6(11736121-11740016) |
ENSEMBL Gene Tree for BPI (if available)
TreeFam Gene Tree for BPI (if available) |
Paralogs
for BPI gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BPI gene
- BPIFB42 BPIFB62 BPIFB22 PLTP2 BPIFB32 BPIFC2 LBP2
3 SIMAP similar genes for BPI using alignment to 5 protein entries: BPI_HUMAN (see all proteins):LBP BPIFC PLTP
BPI for paralogs About GeneDecksing
|
Genomic Variants
for BPI gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BPI (36888551 - 36965907 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for BPI
4 CNVs: 9824 8884 3217 4101
Human Gene Mutation Database (HGMD): BPI
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BPI |
|
Disorders
/ Diseases
for BPI gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BPI for disorders About GeneDecksing
OMIM gene information: 109195
OMIM disorders: --
20/47  diseases for BPI (see all 47): About MalaCardsalpha 1-antitrypsin deficiency stenotrophomonas maltophilia wegener's granulomatosis sclerosing cholangitis
primary sclerosing cholangitis meningococcemia inflammatory bowel disease cholangitis
cystic fibrosis diabetic retinopathy cystic fibrosis lung disease bronchiectasis
reactive arthritis leukopenia arthropathy morbid obesity
psoriatic arthritis rheumatoid arthritis ulcerative colitis myocardial infarction
3 diseases from the University of Copenhagen DISEASES database for BPI:Vasculitis Cystic fibrosis Inflammatory bowel disease 10/44 Novoseek disease relationships for BPI gene (see all 44) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gram-negative bacterial infections |
78.2 |
8 |
7613727 (2), 20107854 (1), 12869032 (1), 11310835 (1) (see all 7) |
| nasal epithelium |
62 |
3 |
12427544 (1), 14630892 (1) |
| vasculitis |
62 |
7 |
8603534 (1), 16610259 (1), 9404779 (1), 7813109 (1) (see all 6) |
| shock endotoxic |
59.2 |
6 |
7706502 (2), 8501324 (1), 1729370 (1), 8063410 (1) |
| shock septic |
55.4 |
6 |
14504103 (1), 7798655 (1), 8161370 (1), 10586550 (1) (see all 5) |
| systemic inflammatory response syndrome |
52.1 |
5 |
8745023 (2), 8648149 (1), 7538550 (1) |
| sepsis |
51.6 |
38 |
11089749 (4), 8648149 (3), 7508221 (3), 18241571 (2) (see all 17) |
| meningococcemia |
51.5 |
1 |
11445748 (1) |
| colitis ulcerative |
51.4 |
19 |
10521980 (4), 9930392 (3), 15626895 (2), 9155585 (2) (see all 8) |
| inflammatory bowel diseases |
49.5 |
17 |
9155585 (4), 15626895 (2), 8603534 (2), 20107854 (1) (see all 10) |
Genetic Association Database (GAD): BPI
Human Genome Epidemiology (HuGE) Navigator: BPI (28 documents)
Export disorders for BPI gene to outside databases
|
Publications
for BPI gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BPI gene, integrated from 9 sources (see all 301):
(articles sorted by number of sources associating them with BPI) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Polymorphisms in the lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein in patients with myocardial infarction. (PubMed id 12521224)1, 4, 9 Hubacek J.A....Poledne R. (2002)
- Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS- mediated cell activation. (PubMed id 7517398)1, 2, 9 Wilde C.G.... Scott R.W. (1994)
- Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis. (PubMed id 11373419)1, 4, 9 Hubacek J.A....Schmitz G. (2001)
- Crystal structure of human BPI and two bound phospholipids at 2.4-A resolution. (PubMed id 9188532)1, 2, 9 Beamer L.J.... Eisenberg D. (1997)
- The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20. (PubMed id 8432532)1, 3, 9 Gray P.W....Shows T.B. (1993)
- A polymorphism of the bactericidal/permeability increasing protein (BPI) gene is associated with Crohn's disease. (PubMed id 15758620)1, 4 Klein W....Griga T. (2005)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations. (PubMed id 2722846)1, 2 Gray P.W....Elsbach P. (1989)
- Antibiotic proteins of human polymorphonuclear leukocytes. (PubMed id 2501794)1, 2 Gabay J.E.... Nathan C.F. (1989)
- A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability- increasing protein. (PubMed id 3667613)1, 2 Ooi C.E.... Mannion B. (1987)
|
External Searches for BPI gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BPI gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BPI gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BPI gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BPI | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BPI gene:
Search GeneIP for patents involving BPI
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for BPI gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BPI | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BPI | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BPI | | | OriGene Protein Over-expression Lysate for BPI | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BPI | | OriGene 3'-UTR Clone for BPI | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPI | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPI | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BPI | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BPI | | OriGene Custom Protein Services for BPI | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BPI | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BPI | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BPI | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BPI | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BPI | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BPI |
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| | | | Search Tocris compounds for BPI |
| |  |  |  |  | | | | | | Recombinant Protein for BPI |
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 | | | BPI Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPI |
|  |  |  | | | | ThermoFisher Antibody for BPI |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPI |
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