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Aliases for BPHL Gene

Aliases for BPHL Gene

  • Biphenyl Hydrolase Like 2 3
  • Breast Epithelial Mucin-Associated Antigen 2 3 4
  • Biphenyl Hydrolase-Like (Serine Hydrolase) 2 3 5
  • Biphenyl Hydrolase-Related Protein 3 4
  • Valacyclovir Hydrolase 2 3
  • Valacyclovirase 3 4
  • VACVASE 3 4
  • BPH-RP 3 4
  • MCNAA 3 4
  • Biphenyl Hydrolase-Like Protein 4
  • EC 3.1.-.- 4

External Ids for BPHL Gene

Previous HGNC Symbols for BPHL Gene

  • MCNAA

Previous GeneCards Identifiers for BPHL Gene

  • GC06P003104
  • GC06P003063
  • GC06P002998

Summaries for BPHL Gene

Entrez Gene Summary for BPHL Gene

  • This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

GeneCards Summary for BPHL Gene

BPHL (Biphenyl Hydrolase Like) is a Protein Coding gene. Among its related pathways are cytochrome P450 and Metabolism. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for BPHL Gene

  • Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPHL Gene

Genomics for BPHL Gene

Regulatory Elements for BPHL Gene

Enhancers for BPHL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BPHL on UCSC Golden Path with GeneCards custom track

Promoters for BPHL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for BPHL Gene

Chromosome:
6
Start:
3,118,374 bp from pter
End:
3,153,578 bp from pter
Size:
35,205 bases
Orientation:
Plus strand

Genomic View for BPHL Gene

Genes around BPHL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPHL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPHL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPHL Gene

Proteins for BPHL Gene

  • Protein details for BPHL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WA6-BPHL_HUMAN
    Recommended name:
    Valacyclovir hydrolase
    Protein Accession:
    Q86WA6
    Secondary Accessions:
    • Q00306
    • Q13855
    • Q3KP51

    Protein attributes for BPHL Gene

    Size:
    291 amino acids
    Molecular mass:
    32543 Da
    Quaternary structure:
    • Monomer. May also form homodimers.

    Three dimensional structures from OCA and Proteopedia for BPHL Gene

    Alternative splice isoforms for BPHL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BPHL Gene

Post-translational modifications for BPHL Gene

  • Ubiquitination at Lys 87 and Lys 191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BPHL Gene

Domains & Families for BPHL Gene

Suggested Antigen Peptide Sequences for BPHL Gene

Graphical View of Domain Structure for InterPro Entry

Q86WA6

UniProtKB/Swiss-Prot:

BPHL_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with BPHL: view

No data available for Gene Families for BPHL Gene

Function for BPHL Gene

Molecular function for BPHL Gene

GENATLAS Biochemistry:
biphenyl hydrolase related protein,highly expressed in liver and kidney,involved in the degradation of polychlorinated biphenyls
UniProtKB/Swiss-Prot Function:
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.

Enzyme Numbers (IUBMB) for BPHL Gene

Gene Ontology (GO) - Molecular Function for BPHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IBA --
GO:0047658 alpha-amino-acid esterase activity TAS --
genes like me logo Genes that share ontologies with BPHL: view
genes like me logo Genes that share phenotypes with BPHL: view

Animal Models for BPHL Gene

MGI Knock Outs for BPHL:
  • Bphl tm1b(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for BPHL

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for BPHL Gene

Localization for BPHL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BPHL Gene COMPARTMENTS Subcellular localization image for BPHL gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for BPHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005741 mitochondrial outer membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with BPHL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BPHL Gene

Pathways & Interactions for BPHL Gene

genes like me logo Genes that share pathways with BPHL: view

Pathways by source for BPHL Gene

Interacting Proteins for BPHL Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369739%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000376076%0d%0a9606.ENSP00000250495%0d%0a
Selected Interacting proteins: ENSP00000369739 for BPHL Gene via STRING

Gene Ontology (GO) - Biological Process for BPHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process TAS 7759552
GO:0006805 xenobiotic metabolic process TAS --
GO:0009636 response to toxic substance TAS 7759552
genes like me logo Genes that share ontologies with BPHL: view

No data available for SIGNOR curated interactions for BPHL Gene

Drugs & Compounds for BPHL Gene

(5) Drugs for BPHL Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Tyrosinamide Experimental Pharma Target 0

(1) Additional Compounds for BPHL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BPHL: view

Transcripts for BPHL Gene

Unigene Clusters for BPHL Gene

Biphenyl hydrolase-like (serine hydrolase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPHL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:
SP6: -

Relevant External Links for BPHL Gene

GeneLoc Exon Structure for
BPHL
ECgene alternative splicing isoforms for
BPHL

Expression for BPHL Gene

mRNA expression in normal human tissues for BPHL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BPHL Gene

This gene is overexpressed in Liver (x5.5) and Kidney - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for BPHL Gene

This gene is overexpressed in Gallbladder (12.7), Liver, secretome (12.0), Liver (10.5), and Kidney (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BPHL Gene



Protein tissue co-expression partners for BPHL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BPHL Gene:

BPHL

SOURCE GeneReport for Unigene cluster for BPHL Gene:

Hs.10136

mRNA Expression by UniProt/SwissProt for BPHL Gene:

Q86WA6-BPHL_HUMAN
Tissue specificity: Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle.
genes like me logo Genes that share expression patterns with BPHL: view

Primer Products

Orthologs for BPHL Gene

This gene was present in the common ancestor of animals.

Orthologs for BPHL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BPHL 34
  • 81.9 (n)
  • 85.22 (a)
BPHL 35
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BPHL 34
  • 85.45 (n)
  • 87.29 (a)
BPHL 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bphl 34
  • 82.73 (n)
  • 84.31 (a)
Bphl 16
Bphl 35
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BPHL 34
  • 98.97 (n)
  • 98.97 (a)
BPHL 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bphl 34
  • 84.06 (n)
  • 84.67 (a)
oppossum
(Monodelphis domestica)
Mammalia BPHL 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BPHL 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves BPHL 34
  • 73.82 (n)
  • 78.54 (a)
BPHL 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BPHL 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bphl 34
  • 65.89 (n)
  • 64.86 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12500 34
LOC402804 34
  • 61.85 (n)
  • 62.89 (a)
BPHL 35
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5119 34
fruit fly
(Drosophila melanogaster)
Insecta CG5377 36
  • 45 (a)
CG5377 34
  • 51.46 (n)
  • 45.63 (a)
CG5377 35
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003440 34
  • 52.69 (n)
  • 47.58 (a)
worm
(Caenorhabditis elegans)
Secernentea K01A2.5 34
  • 42.14 (n)
  • 25.61 (a)
K01A2.5 35
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToOne
Species where no ortholog for BPHL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BPHL Gene

ENSEMBL:
Gene Tree for BPHL (if available)
TreeFam:
Gene Tree for BPHL (if available)

Paralogs for BPHL Gene

No data available for Paralogs for BPHL Gene

Variants for BPHL Gene

Sequence variations from dbSNP and Humsavar for BPHL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs957638 -- 3,136,392(-) GTGAG(C/T)TGAAG intron-variant
rs1002852 -- 3,151,625(+) TATTG(C/T)CCTTT intron-variant
rs1009263 -- 3,130,194(-) GGTAC(A/G)TGGGC intron-variant
rs1060332 -- 3,153,143(+) CATTG(C/T)CTTAA nc-transcript-variant, utr-variant-3-prime
rs1137421 -- 3,152,919(+) cccag(C/G)tgctc nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BPHL Gene

Variant ID Type Subtype PubMed ID
dgv10273n54 CNV gain 21841781
dgv10274n54 CNV gain 21841781
esv1223146 CNV deletion 17803354
esv23049 CNV loss 19812545
esv2731486 CNV deletion 23290073
esv2731487 CNV deletion 23290073
esv2741096 CNV deletion 23290073
esv990601 CNV loss 20482838
nsv462614 CNV gain 19166990
nsv513294 CNV loss 21212237
nsv600835 CNV loss 21841781
nsv600836 CNV gain+loss 21841781
nsv600839 CNV gain 21841781
nsv600846 CNV gain 21841781
nsv821003 CNV duplication 20802225
nsv950763 CNV deletion 24416366

Variation tolerance for BPHL Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BPHL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BPHL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPHL Gene

Disorders for BPHL Gene

Relevant External Links for BPHL

Genetic Association Database (GAD)
BPHL
Human Genome Epidemiology (HuGE) Navigator
BPHL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPHL

No disorders were found for BPHL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPHL Gene

Publications for BPHL Gene

  1. A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein. (PMID: 15832508) Kim I. … Amidon G.L. (Mol. Pharm. 2004) 2 3 4 22 65
  2. Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL). (PMID: 9721218) Puente X.S. … Lopez-Otin C. (Genomics 1998) 2 3 4 22 65
  3. Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds. (PMID: 7759552) Puente X.S. … Lopez-Otin C. (J. Biol. Chem. 1995) 2 3 4 22 65
  4. Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase. (PMID: 18256025) Lai L. … Amidon G.L. (J. Biol. Chem. 2008) 3 4 22 65
  5. Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase. (PMID: 12732646) Kim I. … Amidon G.L. (J. Biol. Chem. 2003) 3 4 22 65

Products for BPHL Gene

Sources for BPHL Gene

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