Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BPHL Gene

Aliases for BPHL Gene

  • Biphenyl Hydrolase Like 2 3 5
  • Breast Epithelial Mucin-Associated Antigen 2 3 4
  • Biphenyl Hydrolase-Like (Serine Hydrolase) 2 3
  • Biphenyl Hydrolase-Related Protein 3 4
  • Valacyclovir Hydrolase 2 3
  • Valacyclovirase 3 4
  • VACVASE 3 4
  • BPH-RP 3 4
  • MCNAA 3 4
  • Biphenyl Hydrolase-Like Protein 4
  • EC 3.1.-.- 4

External Ids for BPHL Gene

Previous HGNC Symbols for BPHL Gene

  • MCNAA

Previous GeneCards Identifiers for BPHL Gene

  • GC06P003104
  • GC06P003063
  • GC06P002998

Summaries for BPHL Gene

Entrez Gene Summary for BPHL Gene

  • This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

GeneCards Summary for BPHL Gene

BPHL (Biphenyl Hydrolase Like) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for BPHL Gene

  • Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.

Additional gene information for BPHL Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPHL Gene

Genomics for BPHL Gene

Regulatory Elements for BPHL Gene

Enhancers for BPHL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H003156 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +43.7 43734 11 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 TUBB2A TUBB2B TUBB2BP1 PRPF4B PSMG4 C6orf201 RIPK1 BPHL LOC105374889
GH06H003207 1.7 FANTOM5 Ensembl ENCODE 12 +90.7 90717 3 PKNOX1 SIN3A ZNF766 FOS SP3 ZHX2 JUNB REST ZNF592 KAT8 TUBB2B PSMG4 TUBB2A BPHL ENSG00000228170 SERPINB9 GC06P003208 GC06P003221
GH06H003246 1.8 VISTA FANTOM5 Ensembl ENCODE 10.9 +129.8 129781 3 HDAC1 FOXA2 MLX NFRKB DMAP1 ZBTB40 ZSCAN9 CBX5 EGR1 FOS TUBB2A TUBB2B ENSG00000228170 BPHL SLC22A23 PIR45758
GH06H003067 1.4 ENCODE dbSUPER 12.7 -49.4 -49442 2 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000272277 PRPF4B HTATSF1P2 PSMG4 BPHL GC06P003076
GH06H003137 1.5 Ensembl ENCODE dbSUPER 11.4 +20.5 20505 2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 FOS TUBB2B TUBB2BP1 BPHL PSMG4 GC06P003150
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BPHL on UCSC Golden Path with GeneCards custom track

Promoters for BPHL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000192178 426 1601 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9

Genomic Location for BPHL Gene

Chromosome:
6
Start:
3,118,374 bp from pter
End:
3,153,578 bp from pter
Size:
35,205 bases
Orientation:
Plus strand

Genomic View for BPHL Gene

Genes around BPHL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPHL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPHL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPHL Gene

Proteins for BPHL Gene

  • Protein details for BPHL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WA6-BPHL_HUMAN
    Recommended name:
    Valacyclovir hydrolase
    Protein Accession:
    Q86WA6
    Secondary Accessions:
    • Q00306
    • Q13855
    • Q3KP51

    Protein attributes for BPHL Gene

    Size:
    291 amino acids
    Molecular mass:
    32543 Da
    Quaternary structure:
    • Monomer. May also form homodimers.

    Three dimensional structures from OCA and Proteopedia for BPHL Gene

    Alternative splice isoforms for BPHL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BPHL Gene

Post-translational modifications for BPHL Gene

  • Ubiquitination at Lys87 and Lys191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BPHL Gene

Domains & Families for BPHL Gene

Gene Families for BPHL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for BPHL Gene

Graphical View of Domain Structure for InterPro Entry

Q86WA6

UniProtKB/Swiss-Prot:

BPHL_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with BPHL: view

Function for BPHL Gene

Molecular function for BPHL Gene

GENATLAS Biochemistry:
biphenyl hydrolase related protein,highly expressed in liver and kidney,involved in the degradation of polychlorinated biphenyls
UniProtKB/Swiss-Prot Function:
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.

Enzyme Numbers (IUBMB) for BPHL Gene

Phenotypes From GWAS Catalog for BPHL Gene

Gene Ontology (GO) - Molecular Function for BPHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA,IBA --
GO:0047658 alpha-amino-acid esterase activity TAS --
genes like me logo Genes that share ontologies with BPHL: view
genes like me logo Genes that share phenotypes with BPHL: view

Animal Models for BPHL Gene

MGI Knock Outs for BPHL:
  • Bphl tm1b(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for BPHL

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BPHL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for BPHL Gene

Localization for BPHL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BPHL gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BPHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005741 mitochondrial outer membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with BPHL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BPHL Gene

Pathways & Interactions for BPHL Gene

genes like me logo Genes that share pathways with BPHL: view

Pathways by source for BPHL Gene

Interacting Proteins for BPHL Gene

Gene Ontology (GO) - Biological Process for BPHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process TAS 7759552
GO:0006805 xenobiotic metabolic process TAS --
GO:0009636 response to toxic substance TAS 7759552
genes like me logo Genes that share ontologies with BPHL: view

No data available for SIGNOR curated interactions for BPHL Gene

Drugs & Compounds for BPHL Gene

(5) Drugs for BPHL Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Tyrosinamide Experimental Pharma Target 0

(1) Additional Compounds for BPHL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BPHL: view

Transcripts for BPHL Gene

Unigene Clusters for BPHL Gene

Biphenyl hydrolase-like (serine hydrolase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BPHL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for BPHL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:
SP6: -

Relevant External Links for BPHL Gene

GeneLoc Exon Structure for
BPHL
ECgene alternative splicing isoforms for
BPHL

Expression for BPHL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BPHL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BPHL Gene

This gene is overexpressed in Liver (x5.5) and Kidney - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for BPHL Gene

This gene is overexpressed in Gallbladder (12.7), Liver, secretome (12.0), Liver (10.5), and Kidney (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BPHL Gene



Protein tissue co-expression partners for BPHL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BPHL Gene:

BPHL

SOURCE GeneReport for Unigene cluster for BPHL Gene:

Hs.10136

mRNA Expression by UniProt/SwissProt for BPHL Gene:

Q86WA6-BPHL_HUMAN
Tissue specificity: Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle.

Evidence on tissue expression from TISSUES for BPHL Gene

  • Kidney(2.2)
genes like me logo Genes that share expression patterns with BPHL: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BPHL Gene

Orthologs for BPHL Gene

This gene was present in the common ancestor of animals.

Orthologs for BPHL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPHL 33 34
  • 98.97 (n)
dog
(Canis familiaris)
Mammalia BPHL 33 34
  • 85.45 (n)
rat
(Rattus norvegicus)
Mammalia Bphl 33
  • 84.06 (n)
oppossum
(Monodelphis domestica)
Mammalia BPHL 34
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bphl 33 16 34
  • 82.73 (n)
cow
(Bos Taurus)
Mammalia BPHL 33 34
  • 81.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BPHL 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves BPHL 33 34
  • 73.82 (n)
lizard
(Anolis carolinensis)
Reptilia BPHL 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bphl 33
  • 65.89 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC402804 33
  • 61.85 (n)
BPHL 34
  • 55 (a)
OneToOne
Dr.12500 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5119 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003440 33
  • 52.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5377 35 33 34
  • 51.46 (n)
worm
(Caenorhabditis elegans)
Secernentea K01A2.5 33 34
  • 42.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
Species where no ortholog for BPHL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BPHL Gene

ENSEMBL:
Gene Tree for BPHL (if available)
TreeFam:
Gene Tree for BPHL (if available)

Paralogs for BPHL Gene

No data available for Paralogs for BPHL Gene

Variants for BPHL Gene

Sequence variations from dbSNP and Humsavar for BPHL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000037533 -- 3,118,459(+) GCAGC(G/T)CCGAC nc-transcript-variant, utr-variant-5-prime
rs1000052060 -- 3,140,210(+) AAAGG(A/G)AACCC intron-variant
rs1000114830 -- 3,125,245(+) TCACC(A/G)TGTTG intron-variant
rs1000200136 -- 3,149,763(+) TAGCT(A/G)GGATT intron-variant
rs1000331857 -- 3,141,826(+) AAAAT(C/T)AGCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPHL Gene

Variant ID Type Subtype PubMed ID
dgv10273n54 CNV gain 21841781
dgv10274n54 CNV gain 21841781
esv1223146 CNV deletion 17803354
esv23049 CNV loss 19812545
esv2731486 CNV deletion 23290073
esv2731487 CNV deletion 23290073
esv2741096 CNV deletion 23290073
esv990601 CNV loss 20482838
nsv462614 CNV gain 19166990
nsv513294 CNV loss 21212237
nsv600835 CNV loss 21841781
nsv600836 CNV gain+loss 21841781
nsv600839 CNV gain 21841781
nsv600846 CNV gain 21841781
nsv821003 CNV duplication 20802225
nsv950763 CNV deletion 24416366

Variation tolerance for BPHL Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BPHL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BPHL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPHL Gene

Disorders for BPHL Gene

Relevant External Links for BPHL

Genetic Association Database (GAD)
BPHL
Human Genome Epidemiology (HuGE) Navigator
BPHL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPHL

No disorders were found for BPHL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPHL Gene

Publications for BPHL Gene

  1. A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein. (PMID: 15832508) Kim I … Amidon GL (Molecular pharmaceutics 2004) 2 3 4 22 60
  2. Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL). (PMID: 9721218) Puente XS … López-otín C (Genomics 1998) 2 3 4 22 60
  3. Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds. (PMID: 7759552) Puente XS … López-Otín C (The Journal of biological chemistry 1995) 2 3 4 22 60
  4. Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase. (PMID: 18256025) Lai L … Amidon GL (The Journal of biological chemistry 2008) 3 4 22 60
  5. Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase. (PMID: 12732646) Kim I … Amidon GL (The Journal of biological chemistry 2003) 3 4 22 60

Products for BPHL Gene

Sources for BPHL Gene

Content
Loading form....