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Aliases for BPHL Gene

Aliases for BPHL Gene

  • Biphenyl Hydrolase-Like (Serine Hydrolase) 2 3 5
  • Breast Epithelial Mucin-Associated Antigen 2 3 4
  • Biphenyl Hydrolase-Related Protein 3 4
  • Valacyclovirase 3 4
  • VACVASE 3 4
  • BPH-RP 3 4
  • MCNAA 3 4
  • Biphenyl Hydrolase-Like Protein 4
  • EC 3.1.-.- 4

External Ids for BPHL Gene

Previous HGNC Symbols for BPHL Gene

  • MCNAA

Previous GeneCards Identifiers for BPHL Gene

  • GC06P003104
  • GC06P003063
  • GC06P002998

Summaries for BPHL Gene

Entrez Gene Summary for BPHL Gene

  • This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

GeneCards Summary for BPHL Gene

BPHL (Biphenyl Hydrolase-Like (Serine Hydrolase)) is a Protein Coding gene. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for BPHL Gene

  • Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPHL Gene

Genomics for BPHL Gene

Regulatory Elements for BPHL Gene

Promoters for BPHL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BPHL on UCSC Golden Path with GeneCards custom track

Genomic Location for BPHL Gene

Chromosome:
6
Start:
3,118,374 bp from pter
End:
3,153,578 bp from pter
Size:
35,205 bases
Orientation:
Plus strand

Genomic View for BPHL Gene

Genes around BPHL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPHL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPHL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPHL Gene

Proteins for BPHL Gene

  • Protein details for BPHL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WA6-BPHL_HUMAN
    Recommended name:
    Valacyclovir hydrolase
    Protein Accession:
    Q86WA6
    Secondary Accessions:
    • Q00306
    • Q13855
    • Q3KP51

    Protein attributes for BPHL Gene

    Size:
    291 amino acids
    Molecular mass:
    32543 Da
    Quaternary structure:
    • Monomer. May also form homodimers.

    Three dimensional structures from OCA and Proteopedia for BPHL Gene

    Alternative splice isoforms for BPHL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BPHL Gene

Proteomics data for BPHL Gene at MOPED

Post-translational modifications for BPHL Gene

  • Ubiquitination at Lys 87 and Lys 191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BPHL Gene

Domains & Families for BPHL Gene

Suggested Antigen Peptide Sequences for BPHL Gene

Graphical View of Domain Structure for InterPro Entry

Q86WA6

UniProtKB/Swiss-Prot:

BPHL_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with BPHL: view

No data available for Gene Families for BPHL Gene

Function for BPHL Gene

Molecular function for BPHL Gene

GENATLAS Biochemistry:
biphenyl hydrolase related protein,highly expressed in liver and kidney,involved in the degradation of polychlorinated biphenyls
UniProtKB/Swiss-Prot Function:
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.

Enzyme Numbers (IUBMB) for BPHL Gene

genes like me logo Genes that share phenotypes with BPHL: view

Animal Models for BPHL Gene

MGI Knock Outs for BPHL:
  • Bphl tm1b(EUCOMM)Hmgu

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for BPHL Gene

Localization for BPHL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BPHL Gene COMPARTMENTS Subcellular localization image for BPHL gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for BPHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
genes like me logo Genes that share ontologies with BPHL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BPHL Gene

Pathways & Interactions for BPHL Gene

genes like me logo Genes that share pathways with BPHL: view

Pathways by source for BPHL Gene

Interacting Proteins for BPHL Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369739%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000376076%0d%0a9606.ENSP00000250495%0d%0a
Selected Interacting proteins: ENSP00000369739 for BPHL Gene via STRING

Gene Ontology (GO) - Biological Process for BPHL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process TAS 7759552
genes like me logo Genes that share ontologies with BPHL: view

No data available for SIGNOR curated interactions for BPHL Gene

Drugs & Compounds for BPHL Gene

(5) Drugs for BPHL Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Tyrosinamide Experimental Pharma Target 0

(1) Additional Compounds for BPHL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BPHL: view

Transcripts for BPHL Gene

Unigene Clusters for BPHL Gene

Biphenyl hydrolase-like (serine hydrolase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BPHL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5:
SP6: -

Relevant External Links for BPHL Gene

GeneLoc Exon Structure for
BPHL
ECgene alternative splicing isoforms for
BPHL

Expression for BPHL Gene

mRNA expression in normal human tissues for BPHL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BPHL Gene

This gene is overexpressed in Liver (x5.5) and Kidney - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for BPHL Gene

This gene is overexpressed in Gallbladder (12.7), Liver, secretome (12.0), Liver (10.5), and Kidney (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BPHL Gene



SOURCE GeneReport for Unigene cluster for BPHL Gene Hs.10136

mRNA Expression by UniProt/SwissProt for BPHL Gene

Q86WA6-BPHL_HUMAN
Tissue specificity: Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle.
genes like me logo Genes that share expression patterns with BPHL: view

Protein tissue co-expression partners for BPHL Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for BPHL Gene

This gene was present in the common ancestor of animals.

Orthologs for BPHL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPHL 35
  • 98.97 (n)
  • 98.97 (a)
BPHL 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BPHL 36
  • 52 (a)
OneToOne
BPHL 35
  • 81.9 (n)
  • 85.22 (a)
dog
(Canis familiaris)
Mammalia BPHL 35
  • 85.45 (n)
  • 87.29 (a)
BPHL 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bphl 16
Bphl 36
  • 82 (a)
OneToOne
Bphl 35
  • 82.73 (n)
  • 84.31 (a)
oppossum
(Monodelphis domestica)
Mammalia BPHL 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BPHL 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bphl 35
  • 84.06 (n)
  • 84.67 (a)
chicken
(Gallus gallus)
Aves BPHL 36
  • 73 (a)
OneToOne
BPHL 35
  • 73.82 (n)
  • 78.54 (a)
lizard
(Anolis carolinensis)
Reptilia BPHL 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bphl 35
  • 65.89 (n)
  • 64.86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5119 35
zebrafish
(Danio rerio)
Actinopterygii BPHL 36
  • 55 (a)
OneToOne
LOC402804 35
  • 61.85 (n)
  • 62.89 (a)
Dr.12500 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003440 35
  • 52.69 (n)
  • 47.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5377 35
  • 51.46 (n)
  • 45.63 (a)
CG5377 37
  • 45 (a)
CG5377 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K01A2.5 36
  • 24 (a)
OneToOne
K01A2.5 35
  • 42.14 (n)
  • 25.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for BPHL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BPHL Gene

ENSEMBL:
Gene Tree for BPHL (if available)
TreeFam:
Gene Tree for BPHL (if available)

Paralogs for BPHL Gene

No data available for Paralogs for BPHL Gene

Variants for BPHL Gene

Sequence variations from dbSNP and Humsavar for BPHL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs727259 -- 3,152,210(-) CAAAT(C/G)GTTTG intron-variant
rs727260 -- 3,152,171(-) GTGAT(C/T)TGGTG intron-variant
rs1137421 -- 3,152,919(+) cccag(C/G)tgctc nc-transcript-variant, utr-variant-3-prime
rs1137422 -- 3,152,947(+) ggatc(A/G)cttga nc-transcript-variant, utr-variant-3-prime
rs1060332 -- 3,153,143(+) CATTG(C/T)CTTAA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BPHL Gene

Variant ID Type Subtype PubMed ID
nsv821003 CNV Duplication 20802225
esv990601 CNV Loss 20482838
esv23049 CNV Loss 19812545
esv2731486 CNV Deletion 23290073
nsv513294 CNV Loss 21212237
esv2731487 CNV Deletion 23290073
esv1223146 CNV Deletion 17803354
esv2741096 CNV Deletion 23290073
nsv462614 CNV Gain 19166990
nsv883405 CNV Gain 21882294
nsv883406 CNV Loss 21882294

Variation tolerance for BPHL Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BPHL Gene

HapMap Linkage Disequilibrium report
BPHL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPHL Gene

Disorders for BPHL Gene

Relevant External Links for BPHL

Genetic Association Database (GAD)
BPHL
Human Genome Epidemiology (HuGE) Navigator
BPHL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPHL

No disorders were found for BPHL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPHL Gene

Publications for BPHL Gene

  1. A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein. (PMID: 15832508) Kim I. … Amidon G.L. (Mol. Pharm. 2004) 2 3 4 23 67
  2. Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL). (PMID: 9721218) Puente X.S. … Lopez-Otin C. (Genomics 1998) 2 3 23
  3. Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds. (PMID: 7759552) Puente X.S. … Lopez-Otin C. (J. Biol. Chem. 1995) 2 3 23
  4. Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase. (PMID: 18256025) Lai L. … Amidon G.L. (J. Biol. Chem. 2008) 3 23
  5. Structure and specificity of a human valacyclovir activating enzyme: a homology model of BPHL. (PMID: 16028355) Kim I. … Amidon G.L. (Mol. Pharm. 2004) 3 23

Products for BPHL Gene

Sources for BPHL Gene

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