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BPHL Gene

protein-coding   GIFtS: 52
GCID: GC06P003118

Biphenyl Hydrolase-Like (Serine Hydrolase)


(Previous symbol: MCNAA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Biphenyl Hydrolase-Like (Serine Hydrolase)1 2     valacyclovirase2
MCNAA1 2 3     Bph-rp3
Breast Epithelial Mucin-Associated Antigen1 2 3     EC 3.1.-.-3
Biphenyl Hydrolase-Related Protein2 3     VACVase3
BPH-RP2     Valacyclovirase3
VACVASE2     Biphenyl Hydrolase-Like Protein3
Valacyclovir Hydrolase2     

External Ids:    HGNC: 10941   Entrez Gene: 6702   Ensembl: ENSG000001372747   OMIM: 6031565   UniProtKB: Q86WA63   

Export aliases for BPHL gene to outside databases

Previous GC identifers: GC06P003104 GC06P003063 GC06P002998


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BPHL Gene:
This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their
active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir.
Alternatively spliced transcript variants have been described.(provided by RefSeq, Jan 2009)

GeneCards Summary for BPHL Gene:
BPHL (biphenyl hydrolase-like (serine hydrolase)) is a protein-coding gene. Diseases associated with BPHL include choroiditis, and hepatitis b. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot: BPHL_HUMAN, Q86WA6
Function: Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside
analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in
detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and
aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a
primary alcohol




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the BPHL gene promoter:
         TBP   RFX1   AML1a   FOXD1   Olf-1   Evi-1   C/EBPalpha   RORalpha1   AREB6   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBPHL promoter sequence
   Search Chromatin IP Primers for BPHL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BPHL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25

BPHL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BPHL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P003118:  view genomic region     (about GC identifiers)

Start:
3,118,608 bp from pter      End:
3,153,812 bp from pter
Size:
35,205 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BPHL_HUMAN, Q86WA6 (See protein sequence)
Recommended Name: Valacyclovir hydrolase precursor  
Size: 291 amino acids; 32543 Da
Subunit: Monomer. May also form homodimers
4 PDB 3D structures from and Proteopedia for BPHL:
2OCG (3D)        2OCI (3D)        2OCK (3D)        2OCL (3D)    
Secondary accessions: Q00306 Q13855 Q3KP51
Alternative splicing: 2 isoforms:  Q86WA6-1   Q86WA6-2   

Explore the universe of human proteins at neXtProt for BPHL: NX_Q86WA6

Explore proteomics data for BPHL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys87, Lys191
  • Modification sites at PhosphoSitePlus

  • See BPHL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004323.2  
    ENSEMBL proteins: 
     ENSP00000390472   ENSP00000394072   ENSP00000396637   ENSP00000413762   ENSP00000369739  
     ENSP00000395744   ENSP00000369734   ENSP00000369726  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q86WA6

    3 Blocks protein domains:
    IPB000073 Alpha/beta hydrolase fold
    IPB003089 Alpha/beta hydrolase fold signature
    IPB008262 Lipase


    UniProtKB/Swiss-Prot: BPHL_HUMAN, Q86WA6
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BPHL_HUMAN, Q86WA6
    Function: Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside
    analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in
    detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and
    aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a
    primary alcohol

         Genatlas biochemistry entry for BPHL:
    biphenyl hydrolase related protein,highly expressed in liver and kidney,involved in the degradation of
    polychlorinated biphenyls

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
         
    BPHL for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Bphl (no phenotypes)

    BPHL for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BPHL
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    7 qRT-PCR Assays for microRNAs that regulate BPHL:
    hsa-miR-499-5p hsa-miR-208a hsa-miR-208b hsa-miR-641 hsa-miR-4323 hsa-miR-3617 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidBPHL 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPHL

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--

    BPHL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BPHL
    Interactions:

        Search GeneGlobe Interaction Network for BPHL

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process TAS7759552
    GO:0009636response to toxic substance TAS7759552

    BPHL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BPHL

    1 DrugBank Compound for BPHL    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-TyrosinamideL-Tyrosine amide (see all 2)4985-46-0target--10592235

    5 Novoseek inferred chemical compound relationships for BPHL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    valacyclovir 83.5 9 12732646 (3), 15832508 (2), 16028355 (1)
    acyclovir 58.4 5 15832508 (1), 16028355 (1)
    serine 47.2 15 9721218 (3), 16028355 (2), 7759552 (1), 12732646 (1) (see all 5)
    zidovudine 42.9 1 15832508 (1)
    nucleoside 36.4 14 15832508 (6), 16028355 (3)



    BPHL for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BPHL gene: 
    NM_004332.2  

    Unigene Cluster for BPHL:

    Biphenyl hydrolase-like (serine hydrolase)
    Hs.10136  [show with all ESTs]
    Unigene Representative Sequence: AK124783
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434640 ENST00000424847 ENST00000430655(uc003muz.3 uc011dht.2)
    ENST00000433912 ENST00000380379(uc003mva.3) ENST00000490918 ENST00000479273
    ENST00000488487 ENST00000423798 ENST00000464040 ENST00000380375(uc003muy.3)
    ENST00000380368
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate BPHL:
    hsa-miR-499-5p hsa-miR-208a hsa-miR-208b hsa-miR-641 hsa-miR-4323 hsa-miR-3617 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidBPHL 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: BPHL (NM_004332)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BPHL
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BPHL
      QuantiTect SYBR Green Assays in human, mouse, rat BPHL
      QuantiFast Probe-based Assays in human, mouse, rat BPHL

    Additional mRNA sequence: 

    AJ617684.1 AK124783.1 AK297518.1 AK314909.1 AY927635.1 AY927636.1 BC037778.1 BC106901.1 
    NR_026648.1 NR_026649.1 NR_026650.1 X57653.1 X81372.1 

    14 DOTS entries:

    DT.91682147  DT.453725  DT.100893166  DT.99932223  DT.101982346  DT.75193493  DT.95158504  DT.92427973 
    DT.100059854  DT.92050082  DT.95158498  DT.97824571  DT.95183922  DT.99986278 

    Selected AceView cDNA sequences (see all 121):

    CK904003 CA420674 AI818871 AJ617684 AI017491 BQ669554 CA306822 AI268326 
    AI418120 BU736294 AA887327 AW276222 AI167945 BM476445 AI161218 BM052802 
    AW872800 X81372 AI565320 AI360932 AI383521 Z41013 BP376230 NM_004332 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BPHL (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                -     -                       -                     
    SP2:                                -     -                             -               
    SP3:                    -           -     -                             -               
    SP4:                                -     -                                             
    SP5:                                                                                    


    ECgene alternative splicing isoforms for BPHL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BPHL expression in normal human tissues (normalized intensities)      BPHL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCCTTTGA
    BPHL Expression
    About this image


    BPHL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Epithalamus
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)
    BPHL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BPHL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.10136

    UniProtKB/Swiss-Prot: BPHL_HUMAN, Q86WA6
    Tissue specificity: Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal
    muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPHL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BPHL gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bphl1 , 5 biphenyl hydrolase-like (serine hydrolase, breast epithelial more1, 5 82.73(n)1
    84.31(a)1
      13 (14.02 cM)5
    680211  NM_026512.11  NP_080788.11 
     340376415 
    chicken
    (Gallus gallus)
    Aves BPHL1 biphenyl hydrolase-like (serine hydrolase) 73.82(n)
    78.54(a)
      420885  XM_004939671.1  XP_004939728.1 
    lizard
    (Anolis carolinensis)
    Reptilia BPHL6
    biphenyl hydrolase-like (serine hydrolase)
    72(a)
    1 ↔ 1
    GL343247.1(1017320-1044452)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bphl1 biphenyl hydrolase-like (serine hydrolase) 65.89(n)
    64.86(a)
      100489969  XM_002936417.2  XP_002936463.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125002 Danio rerio, Similar to RIKEN cDNA 2010012D11 gene, more 71.96(n)    BC045899.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53771 , 3 serine hydrolase3
    CG53771
    45(a)3
    51.46(n)1
    45.63(a)1
      94A163
    426451  NM_142795.41  NP_651052.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K01A2.51 K01A2.5 42.14(n)
    25.61(a)
      173418  NM_061300.4  NP_493701.1 


    ENSEMBL Gene Tree for BPHL (if available)
    TreeFam Gene Tree for BPHL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BPHL (see all 1022)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs65969511,2
    C,F,A--3116944(+) TTAGCT/CGGGCA 4 -- us2k16Minor allele frequency- C:0.27NA WA CSA 11
    rs1122046521,2
    C,F--3116952(+) GCATGG/ATGGCG 4 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1481517111,2
    C--3117061(+) CCAGCC/GTGGGC 4 -- us2k10--------
    rs69137301,2
    C,F,H--3117196(+) TCATTT/GCTGAG 4 -- us2k16Minor allele frequency- G:0.04NS EA WA 536
    rs1157537361,2
    C,F--3117201(+) TCTGAG/TATGAA 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs69301901,2
    C,F,A--3117271(+) TCAAAC/TGATAT 4 -- us2k19Minor allele frequency- T:0.18NA WA CSA EA 250
    rs95019241,2
    C,F,A,H--3117521(+) GAGGAG/AAAGAA 4 -- us2k1 trp38Minor allele frequency- A:0.15NS EA NA WA CSA 542
    rs749778241,2
    F--3117537(+) ATATGC/TAAAGA 4 -- us2k11Minor allele frequency- T:0.02WA 118
    rs761625261,2
    F--3117538(+) TATGCA/GAAGAA 4 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1873301061,2
    --3117635(+) TAAAAA/GGCAAT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for BPHL (3118608 - 3153812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BPHL (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731486CNV Deletion23290073
    esv2731487CNV Deletion23290073
    esv1223146CNV Deletion17803354
    esv2741096CNV Deletion23290073
    nsv821003CNV Duplication20802225
    nsv883406CNV Loss21882294
    esv23049CNV Loss19812545
    esv990601CNV Loss20482838
    nsv513294CNV Loss21212237
    nsv462614CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603156    OMIM disorders: --

    5 diseases for BPHL:    About MalaCards
    choroiditis    hepatitis b    breast cancer    hepatitis
    malaria


    BPHL for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for BPHL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 43.2 2 2100557 (1), 1377884 (1)
    breast carcinoma 42 2 12732646 (1)
    tumors 0 2 2095928 (1), 7493358 (1)

    Genetic Association Database (GAD): BPHL
    Human Genome Epidemiology (HuGE) Navigator: BPHL (2 documents)

    Export disorders for BPHL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BPHL gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with BPHL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein. (PubMed id 15832508)1, 2, 3, 9 Kim I....Amidon G.L. (Mol. Pharm. 2004)
    2. Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL). (PubMed id 9721218)1, 2, 3, 9 Puente X.S.... Lopez-Otin C. (Genomics 1998)
    3. Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds. (PubMed id 7759552)1, 2, 3, 9 Puente X.S. and Lopez-Otin C. (J. Biol. Chem. 1995)
    4. Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase. (PubMed id 12732646)1, 2, 9 Kim I.... Amidon G.L. (J. Biol. Chem. 2003)
    5. Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase. (PubMed id 18256025)1, 2, 9 Lai L.... Amidon G.L. (J. Biol. Chem. 2008)
    6. Cloning and sequencing of a complementary DNA encoding a M(r) 70,000 human breast epithelial mucin-associated antigen. (PubMed id 2393862)1, 2, 9 Larocca D.... Ceriani R.L. (Cancer Res. 1990)
    7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. Structure and specificity of a human valacyclovir activating enzyme: a homology model of BPHL. (PubMed id 16028355)1, 9 Kim I....Amidon G.L. (Mol. Pharm. 2004)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 670 HGNC: 1094 AceView: BPHL Ensembl:ENSG00000137274 euGenes: HUgn670
    ECgene: BPHL H-InvDB: BPHL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BPHL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BPHL gene:
    Search GeneIP for patents involving BPHL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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