Aliases for BPHL Gene
External Ids for BPHL Gene
Previous HGNC Symbols for BPHL Gene
Previous GeneCards Identifiers for BPHL Gene
This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
GeneCards Summary for BPHL Gene
BPHL (Biphenyl Hydrolase-Like (Serine Hydrolase)) is a Protein Coding gene. Among its related pathways are Phase II conjugation and cytochrome P450. GO annotations related to this gene include hydrolase activity.
UniProtKB/Swiss-Prot for BPHL Gene
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.