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Aliases & Descriptions for BPGM
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 5.4.2.4,EC 5.4.2.1,EC 3.1.3.13 3
Descriptions 2,3-bisphosphoglycerate mutase 2 2,3-bisphosphoglycerate mutase, erythrocyte 3 2,3-bisphosphoglycerate synthase 3 BPG-dependent PGAM 3 bisphosphoglycerate mutase 2
Search outside databases for aliases for BPGM genePrevious GC identifers: GC07P132674 GC07P133733 GC07P133747 GC07P133788
Summaries for BPGM (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: PMGE_HUMAN, P07738 Function : Plays a major role in regulating hemoglobin oxygen affinity as a consequence ofcontrolling 2,3-BPG concentration. Can also catalyze the reaction of EC 5.4.2.1 (mutase) and EC3.1.3.13 (phosphatase), but with a reduced activity
Genomic Location for BPGM
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the BPGM gene Entrez Gene cytogenetic band: 7q31-q34 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q31-q34 BPGM Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P133982:
(about GC identifiers )
Start:
133,982,095 bp from pter
End:
134,015,108 bp from pter
Size:
33,014 bases
Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 133,675,873-133,708,886
RefSeq DNA sequence: NC_000007.12 NT_007933.14 NT_079596.2 Proteins for BPGM
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: PMGE_HUMAN, P07738 (See
protein sequence )Recommended Name: Bisphosphoglycerate mutase Size : 259 amino acids; 30005 Da
Subunit : Homodimer
PDB structures from and Proteopedia : 1T8P (3D)
 2A9J (3D)
 2F90 (3D)
 2H4X (3D)
 2H4Z (3D)
 2H52 (3D)
 2HHJ (3D)
 
Post-translational modifications:
Glycation of Lys-159 in diabetic patients inactivates the enzyme1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001715.1 NP_954655.1 ENSEMBL proteins: ENSP00000376840 ENSP00000342032 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: BPGM Antibodies for BPGM: Assays for BPGM:
Protein
Domains/ Families for BPGM(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P07738 ProtoNet protein and cluster: P07738
1 Blocks protein family : IPB001345 Phosphoglycerate/bisphosphoglycerate mutase UniProtKB/Swiss-Prot: PMGE_HUMAN, P07738 Similarity : Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily
Gene Function for BPGM
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_199186 Applied Biosystems Silencer ® siRNAs for BPGM Sigma-Aldrich siRNA and siRNA Panels for BPGM Sigma-Aldrich shRNA for BPGM Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001724                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001724                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001724  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_199186 UniProtKB/Swiss-Prot: PMGE_HUMAN, P07738 Function : Plays a major role in regulating hemoglobin oxygen affinity as a consequence ofcontrolling 2,3-BPG concentration. Can also catalyze the reaction of EC 5.4.2.1 (mutase) and EC3.1.3.13 (phosphatase), but with a reduced activity Catalytic activity : 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerateCatalytic activity : 2-phospho-D-glycerate = 3-phospho-D-glycerateCatalytic activity : 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphateEnzyme Number (IUBMB): EC 5.4.2.4,EC
Genatlas biochemistry entry for BPGM :2,3-bisphosphoglycerate mutase,glycolysis,energy pathway,Rapoport-Luebering shunt,major regulationof biphosphoglycerate concentration in erythrocyte 5 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for BPGM
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for BPGM (Your Favorite Gene powered by Ingenuity) 5/14 Interacting proteins for BPGM (ENSP00000342032 3 ) via UniProtKB, MINT, and/or STRING (see all 14
)About this table 5 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for BPGM (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for BPGM 6 Novoseek chemical compound relationships for BPGM gene
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Transcripts for BPGM(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_199186 Sigma-Aldrich siRNA and siRNA Panels for BPGM Sigma-Aldrich shRNA for BPGM Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001724 NM_199186
REFSEQ mRNAs for BPGM gene (2 alternative transcripts): NM_001724.4 NM_199186.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001724 NM_199186
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001724                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001724                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001724  
Additional cDNA sequence: AB209044.1
21 DOTS entries : DT.101977428 DT.315226 DT.100808810 DT.75103877 DT.100808817 DT.95289926 DT.100808820 DT.100808807 DT.100808813 DT.100835729 DT.40194658 DT.40116900 DT.100766481 DT.100734968 DT.121061130 DT.92448520 DT.100776864 DT.121060684 DT.92448521 DT.95139112 DT.100662314
24/338 AceView cDNA sequences (see all 338
):BP371617 CR625693 BU664976 BU752747 AU139082 AI580517 CR598794 CR626310 CR620521 AU138182 BQ918034 AU134644 BC017050 CR619111 BI753556 AI471846 AI174941 AU137396 CR602739 BU663168 AW026124 CR606892 BM722735 AU138641
highest scoring ESTs for BPGM :X04327 AA091699 AA804586 AI042601 AI204516 AI208731 AI249518 AI300761 AI307744 AI347766
Unigene Clusters for BPGM: 2,3-bisphosphoglycerate mutase Hs.198365 [show with all ESTs ] , Hs.719267 [show with all ESTs ] Unigene Representative Sequences: NM_199186 , BX427126 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for BPGM ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 SP1 :     -   -   -                 SP2 :       -   -                 SP3 :     -     -                 SP4 :     -   -   -                 SP5 :                        
About this scheme ECgene alternative splicing isoforms for BPGM 2 Ensembl transcripts including schematic representations : ENST00000393132
ENST00000344924
Expression for BPGM
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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BPGM expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for BPGM 1 / 2 / 3
3 probe-sets matching BPGM gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GAAATAGCAGSOURCE GeneReport for Unigene clusters: Hs.198365 Hs.719267 Expression variation in blood from EXPOLDB for BPGM
Orthologs for BPGM
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for BPGM gene from 5/11 species (see all 11
)
About this table Species with no ortholog for BPGM ENSEMBL Gene Tree for BPGM Paralogs for BPGM (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for BPGM gene PGAM1 2 PGAM2 2 ENSG00000220515 2 PGAM4 2
SNPs/Variants for BPGM (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for BPGM (up to first 250kb)
Disorders & Mutations for BPGM
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 222800
Genatlas disease: BPGM erythrocytosis Human Gene Mutation Database : BPGM
Medical News for BPGM (Possibly Related Articles in
Doctor's Guide )
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--
Publications for BPGM (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/40 PubMed articles for BPGM gene (see all 40
): Structural modeling of the human erythrocyte bisphosphoglycerate mutase. (PubMed id 1387804) 1, 3, 4 Craescu C.T.... Edelstein S.J. (1992) Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro. (PubMed id 9832630) 1, 3, 4 Fujita T.... Taniguchi N. (1998) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The platelet-activating factor acetylhydrolase from human erythrocytes. Purification and properties. (PubMed id 8440681) 3, 4 Stafforini D.M.... McIntyre T.M. (1993) Isolation and characterization of the human 2,3-bisphosphoglycerate mutase gene. (PubMed id 2844822) 3, 4 Joulin V....Cohen-Solal M. (1988) Molecular cloning of the human 2,3-bisphosphoglycerate mutase cDNA and revised amino acid sequence. (PubMed id 3036106) 3, 4 Cohen-Solal M.... Rosa J. (1987) Molecular cloning and sequencing of the human erythrocyte 2,3- bisphosphoglycerate mutase cDNA: revised amino acid sequence. (PubMed id 3023066) 3, 4 Joulin V....Cohen-Solal M. (1986) The complete amino acid sequence of human erythrocyte diphosphoglycerate mutase. (PubMed id 6313356) 3, 4 Haggarty N.W.... Fothergill L.A. (1983) Crystal structure of human bisphosphoglycerate mutase. (PubMed id 15258155) 1, 3 Wang Y....Gong W. (2004) Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase. (PubMed id 17052986) 1, 3 Wang Y....Gong W. (2006)
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Genome Databases showing BPGM
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing BPGM
(According to HUGE )
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Specialized Databases showing BPGM (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for BPGM (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for BPGM:
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