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Aliases for BORCS8-MEF2B Gene

Aliases for BORCS8-MEF2B Gene

  • BORCS8-MEF2B Readthrough 2 5
  • MEF2BNB-MEF2B Readthrough 2 3
  • LOC729991-MEF2B Readthrough 3
  • LOC729991-MEF2B 3
  • MEF2BNB-MEF2B 3
  • MEF2B 3

External Ids for BORCS8-MEF2B Gene

Previous HGNC Symbols for BORCS8-MEF2B Gene

  • MEF2BNB-MEF2B

Summaries for BORCS8-MEF2B Gene

Entrez Gene Summary for BORCS8-MEF2B Gene

  • This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]

GeneCards Summary for BORCS8-MEF2B Gene

BORCS8-MEF2B (BORCS8-MEF2B Readthrough) is a Protein Coding gene. Among its related pathways are cGMP-PKG signaling pathway and Adipogenesis. An important paralog of this gene is MEF2C.

Gene Wiki entry for BORCS8-MEF2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BORCS8-MEF2B Gene

Genomics for BORCS8-MEF2B Gene

Regulatory Elements for BORCS8-MEF2B Gene

Enhancers for BORCS8-MEF2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BORCS8-MEF2B on UCSC Golden Path with GeneCards custom track

Promoters for BORCS8-MEF2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BORCS8-MEF2B on UCSC Golden Path with GeneCards custom track

Genomic Location for BORCS8-MEF2B Gene

Chromosome:
19
Start:
19,145,567 bp from pter
End:
19,192,591 bp from pter
Size:
47,025 bases
Orientation:
Minus strand

Genomic View for BORCS8-MEF2B Gene

Genes around BORCS8-MEF2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BORCS8-MEF2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BORCS8-MEF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BORCS8-MEF2B Gene

Proteins for BORCS8-MEF2B Gene

  • Protein details for BORCS8-MEF2B Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BNR1
    Recommended name:
    Protein BORCS8-MEF2B
    Protein Accession:
    H3BNR1

    Protein attributes for BORCS8-MEF2B Gene

    Size:
    382 amino acids
    Molecular mass:
    40459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BORCS8-MEF2B Gene

Proteomics data for BORCS8-MEF2B Gene at MOPED

Post-translational modifications for BORCS8-MEF2B Gene

No Post-translational modifications

Other Protein References for BORCS8-MEF2B Gene

No data available for DME Specific Peptides for BORCS8-MEF2B Gene

Domains & Families for BORCS8-MEF2B Gene

Protein Domains for BORCS8-MEF2B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BORCS8-MEF2B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BORCS8-MEF2B Gene

Function for BORCS8-MEF2B Gene

genes like me logo Genes that share phenotypes with BORCS8-MEF2B: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BORCS8-MEF2B Gene

Localization for BORCS8-MEF2B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for BORCS8-MEF2B Gene

Pathways & Interactions for BORCS8-MEF2B Gene

genes like me logo Genes that share pathways with BORCS8-MEF2B: view

Pathways by source for BORCS8-MEF2B Gene

Interacting Proteins for BORCS8-MEF2B Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000457957%0d%0a9606.ENSP00000263119%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000080059%0d%0a9606.ENSP00000340995%0d%0a
Selected Interacting proteins: ENSP00000457957 for BORCS8-MEF2B Gene via STRING

Gene Ontology (GO) - Biological Process for BORCS8-MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with BORCS8-MEF2B: view

No data available for SIGNOR curated interactions for BORCS8-MEF2B Gene

Drugs & Compounds for BORCS8-MEF2B Gene

No Compound Related Data Available

Transcripts for BORCS8-MEF2B Gene

Alternative Splicing Database (ASD) splice patterns (SP) for BORCS8-MEF2B Gene

No ASD Table

Relevant External Links for BORCS8-MEF2B Gene

GeneLoc Exon Structure for
BORCS8-MEF2B
ECgene alternative splicing isoforms for
BORCS8-MEF2B

Expression for BORCS8-MEF2B Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BORCS8-MEF2B Gene

Orthologs for BORCS8-MEF2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BORCS8-MEF2B Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 46 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2586 35
zebrafish
(Danio rerio)
Actinopterygii mef2b 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mef-2 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RLM1 36
  • 10 (a)
ManyToMany
SMP1 36
  • 14 (a)
ManyToMany
corn
(Zea mays)
Liliopsida Zm.1104 35
Species with no ortholog for BORCS8-MEF2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for BORCS8-MEF2B Gene

ENSEMBL:
Gene Tree for BORCS8-MEF2B (if available)
TreeFam:
Gene Tree for BORCS8-MEF2B (if available)

Paralogs for BORCS8-MEF2B Gene

Paralogs for BORCS8-MEF2B Gene

genes like me logo Genes that share paralogs with BORCS8-MEF2B: view

Variants for BORCS8-MEF2B Gene

Sequence variations from dbSNP and Humsavar for BORCS8-MEF2B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256811 -- 19,172,742(+) CCAGG(A/G)GAAGG intron-variant
rs12978193 -- 19,172,468(+) CAGGG(C/T)CACCA intron-variant
rs12980269 -- 19,173,322(+) AGATC(A/G)CGCCA intron-variant
rs12980955 -- 19,172,837(+) AGCTG(C/T)GCCGC intron-variant
rs13344831 -- 19,173,175(+) ctggg(C/T)gacag intron-variant

Variation tolerance for BORCS8-MEF2B Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BORCS8-MEF2B Gene

HapMap Linkage Disequilibrium report
BORCS8-MEF2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BORCS8-MEF2B Gene

Disorders for BORCS8-MEF2B Gene

Relevant External Links for BORCS8-MEF2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BORCS8-MEF2B

No disorders were found for BORCS8-MEF2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BORCS8-MEF2B Gene

Publications for BORCS8-MEF2B Gene

  1. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. (PMID: 1748287) Pollock R. … Treisman R. (Genes Dev. 1991) 3 23 67
  2. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3

Products for BORCS8-MEF2B Gene

Sources for BORCS8-MEF2B Gene

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