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Aliases for BORCS8-MEF2B Gene

Aliases for BORCS8-MEF2B Gene

  • BORCS8-MEF2B Readthrough 2 3 5
  • MEF2BNB-MEF2B Readthrough 2 3
  • LOC729991-MEF2B Readthrough 3
  • Myocyte Enhancer Factor 2B 3
  • LOC729991-MEF2B 3
  • MEF2BNB-MEF2B 3
  • MEF2B 3

External Ids for BORCS8-MEF2B Gene

Previous HGNC Symbols for BORCS8-MEF2B Gene

  • MEF2BNB-MEF2B

Summaries for BORCS8-MEF2B Gene

Entrez Gene Summary for BORCS8-MEF2B Gene

  • This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]

GeneCards Summary for BORCS8-MEF2B Gene

BORCS8-MEF2B (BORCS8-MEF2B Readthrough) is a Protein Coding gene. Among its related pathways are AMPK signaling and Adipogenesis. An important paralog of this gene is MEF2B.

Gene Wiki entry for BORCS8-MEF2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BORCS8-MEF2B Gene

Genomics for BORCS8-MEF2B Gene

Regulatory Elements for BORCS8-MEF2B Gene

Enhancers for BORCS8-MEF2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F019112 1.2 Ensembl ENCODE 11.8 +79.4 79354 0.7 BCOR CTCF RFX1 SP2 ZMYM3 REST RAD21 POLR2A GLIS1 SMC3 TMEM161A SLC25A42 ARMC6 SUGP2 MEF2B BORCS8 BORCS8-MEF2B RFXANK HAPLN4 GC19P019107
GH19F019110 0.7 Ensembl 11.8 +82.0 81990 0.8 ZNF664 ZNF121 BCOR CTCF POLR2A RAD21 YY1 TMEM161A SLC25A42 ARMC6 SUGP2 MEF2B BORCS8 BORCS8-MEF2B RFXANK HAPLN4 GC19P019107
GH19F019342 0.8 ENCODE 11.3 -150.3 -150286 0.2 CTCF ARID4B SIN3A MAX THRB ZNF2 RAD21 POLR2A SCRT2 ZNF143 GATAD2A HAPLN4 BORCS8 BORCS8-MEF2B RFXANK MEF2B GC19M019332 GC19P019353
GH19F019333 0.2 ENCODE 11.2 -142.0 -141976 1.3 HDAC1 TBL1XR1 CREB3L1 BMI1 ZNF766 CBX5 FOS SMARCA5 CBFB ZBTB11 HAPLN4 BORCS8 BORCS8-MEF2B RFXANK MEF2B MAU2 YJEFN3 GC19M019332 SUGP1
GH19F019090 0.5 ENCODE 10.8 +101.5 101527 1.3 MBD2 RAD51 POLR2A SCRT2 ZMYM3 USF2 ZBTB7A SLC25A42 TMEM161A MEF2B BORCS8 BORCS8-MEF2B RFXANK GC19P019107
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BORCS8-MEF2B on UCSC Golden Path with GeneCards custom track

Promoters for BORCS8-MEF2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001418367 191 2801 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for BORCS8-MEF2B Gene

Chromosome:
19
Start:
19,145,567 bp from pter
End:
19,192,591 bp from pter
Size:
47,025 bases
Orientation:
Minus strand

Genomic View for BORCS8-MEF2B Gene

Genes around BORCS8-MEF2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BORCS8-MEF2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BORCS8-MEF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BORCS8-MEF2B Gene

Proteins for BORCS8-MEF2B Gene

  • Protein details for BORCS8-MEF2B Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BNR1
    Recommended name:
    Protein BORCS8-MEF2B
    Protein Accession:
    H3BNR1

    Protein attributes for BORCS8-MEF2B Gene

    Size:
    382 amino acids
    Molecular mass:
    40459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BORCS8-MEF2B Gene

Post-translational modifications for BORCS8-MEF2B Gene

No Post-translational modifications

Other Protein References for BORCS8-MEF2B Gene

No data available for DME Specific Peptides for BORCS8-MEF2B Gene

Domains & Families for BORCS8-MEF2B Gene

Protein Domains for BORCS8-MEF2B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BORCS8-MEF2B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BORCS8-MEF2B Gene

Function for BORCS8-MEF2B Gene

Gene Ontology (GO) - Molecular Function for BORCS8-MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with BORCS8-MEF2B: view
genes like me logo Genes that share phenotypes with BORCS8-MEF2B: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BORCS8-MEF2B Gene

Localization for BORCS8-MEF2B Gene

Gene Ontology (GO) - Cellular Components for BORCS8-MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BORCS8-MEF2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for BORCS8-MEF2B Gene

Pathways & Interactions for BORCS8-MEF2B Gene

genes like me logo Genes that share pathways with BORCS8-MEF2B: view

Pathways by source for BORCS8-MEF2B Gene

2 BioSystems pathways for BORCS8-MEF2B Gene
1 KEGG pathway for BORCS8-MEF2B Gene

Interacting Proteins for BORCS8-MEF2B Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000457957%0d%0a9606.ENSP00000263119%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000080059%0d%0a9606.ENSP00000340995%0d%0a
Selected Interacting proteins: ENSP00000457957 for BORCS8-MEF2B Gene via STRING

Gene Ontology (GO) - Biological Process for BORCS8-MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with BORCS8-MEF2B: view

No data available for SIGNOR curated interactions for BORCS8-MEF2B Gene

Transcripts for BORCS8-MEF2B Gene

Alternative Splicing Database (ASD) splice patterns (SP) for BORCS8-MEF2B Gene

No ASD Table

Relevant External Links for BORCS8-MEF2B Gene

GeneLoc Exon Structure for
BORCS8-MEF2B
ECgene alternative splicing isoforms for
BORCS8-MEF2B

Expression for BORCS8-MEF2B Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BORCS8-MEF2B Gene

Orthologs for BORCS8-MEF2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BORCS8-MEF2B Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 48 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii mef2b 35
  • 53 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2586 34
worm
(Caenorhabditis elegans)
Secernentea mef-2 35
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMP1 35
  • 14 (a)
ManyToMany
RLM1 35
  • 10 (a)
ManyToMany
corn
(Zea mays)
Liliopsida Zm.1104 34
Species where no ortholog for BORCS8-MEF2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for BORCS8-MEF2B Gene

ENSEMBL:
Gene Tree for BORCS8-MEF2B (if available)
TreeFam:
Gene Tree for BORCS8-MEF2B (if available)

Paralogs for BORCS8-MEF2B Gene

Paralogs for BORCS8-MEF2B Gene

genes like me logo Genes that share paralogs with BORCS8-MEF2B: view

Variants for BORCS8-MEF2B Gene

Sequence variations from dbSNP and Humsavar for BORCS8-MEF2B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1005980 -- 19,160,689(+) CCCGG(C/G)CCCTG intron-variant
rs1005981 -- 19,162,314(+) ttttt(G/T)tagag intron-variant
rs1005982 -- 19,162,479(+) TGAAA(G/T)GCAGG intron-variant
rs1006056 -- 19,164,391(-) TCAGC(A/C)CTGTC intron-variant
rs1006057 -- 19,163,338(-) acccc(A/G)gctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BORCS8-MEF2B Gene

Variant ID Type Subtype PubMed ID
dgv1730n106 CNV deletion 24896259
esv1336135 CNV deletion 17803354
esv2677504 CNV deletion 23128226
esv2718291 CNV deletion 23290073
esv3093790 CNV deletion 24192839
esv3556145 CNV deletion 23714750
esv3643846 CNV loss 21293372
esv5981 CNV loss 19470904
nsv1134765 CNV deletion 24896259
nsv1151217 CNV deletion 26484159
nsv819543 CNV gain 19587683
nsv833779 CNV loss 17160897

Variation tolerance for BORCS8-MEF2B Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BORCS8-MEF2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BORCS8-MEF2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BORCS8-MEF2B Gene

Disorders for BORCS8-MEF2B Gene

Relevant External Links for BORCS8-MEF2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BORCS8-MEF2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BORCS8-MEF2B

No disorders were found for BORCS8-MEF2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BORCS8-MEF2B Gene

Publications for BORCS8-MEF2B Gene

  1. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. (PMID: 1748287) Pollock R. … Treisman R. (Genes Dev. 1991) 3 22 64
  2. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 64
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64

Products for BORCS8-MEF2B Gene

Sources for BORCS8-MEF2B Gene

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