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Aliases for BORCS8-MEF2B Gene

Aliases for BORCS8-MEF2B Gene

  • BORCS8-MEF2B Readthrough 2 5
  • MEF2BNB-MEF2B Readthrough 2 3
  • LOC729991-MEF2B Readthrough 3
  • LOC729991-MEF2B 3
  • MEF2B 3

External Ids for BORCS8-MEF2B Gene

Previous HGNC Symbols for BORCS8-MEF2B Gene


Summaries for BORCS8-MEF2B Gene

Entrez Gene Summary for BORCS8-MEF2B Gene

  • This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]

GeneCards Summary for BORCS8-MEF2B Gene

BORCS8-MEF2B (BORCS8-MEF2B Readthrough) is a Protein Coding gene. Among its related pathways are Transcriptional activation of mitochondrial biogenesis and miRs in Muscle Cell Differentiation. An important paralog of this gene is MEF2C.

Gene Wiki entry for BORCS8-MEF2B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BORCS8-MEF2B Gene

Genomics for BORCS8-MEF2B Gene

Regulatory Elements for BORCS8-MEF2B Gene

Enhancers for BORCS8-MEF2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BORCS8-MEF2B on UCSC Golden Path with GeneCards custom track

Promoters for BORCS8-MEF2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BORCS8-MEF2B on UCSC Golden Path with GeneCards custom track

Genomic Location for BORCS8-MEF2B Gene

19,145,567 bp from pter
19,192,591 bp from pter
47,025 bases
Minus strand

Genomic View for BORCS8-MEF2B Gene

Genes around BORCS8-MEF2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BORCS8-MEF2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BORCS8-MEF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BORCS8-MEF2B Gene

Proteins for BORCS8-MEF2B Gene

  • Protein details for BORCS8-MEF2B Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein BORCS8-MEF2B
    Protein Accession:

    Protein attributes for BORCS8-MEF2B Gene

    382 amino acids
    Molecular mass:
    40459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BORCS8-MEF2B Gene

Proteomics data for BORCS8-MEF2B Gene at MOPED

Post-translational modifications for BORCS8-MEF2B Gene

No Post-translational modifications

Other Protein References for BORCS8-MEF2B Gene

No data available for DME Specific Peptides for BORCS8-MEF2B Gene

Domains & Families for BORCS8-MEF2B Gene

Protein Domains for BORCS8-MEF2B Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BORCS8-MEF2B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BORCS8-MEF2B Gene

Function for BORCS8-MEF2B Gene

genes like me logo Genes that share phenotypes with BORCS8-MEF2B: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BORCS8-MEF2B Gene

Localization for BORCS8-MEF2B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for BORCS8-MEF2B Gene

Pathways & Interactions for BORCS8-MEF2B Gene

genes like me logo Genes that share pathways with BORCS8-MEF2B: view

Pathways by source for BORCS8-MEF2B Gene

Interacting Proteins for BORCS8-MEF2B Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000457957 for BORCS8-MEF2B Gene via STRING

Gene Ontology (GO) - Biological Process for BORCS8-MEF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with BORCS8-MEF2B: view

No data available for SIGNOR curated interactions for BORCS8-MEF2B Gene

Drugs & Compounds for BORCS8-MEF2B Gene

No Compound Related Data Available

Transcripts for BORCS8-MEF2B Gene

Alternative Splicing Database (ASD) splice patterns (SP) for BORCS8-MEF2B Gene

No ASD Table

Relevant External Links for BORCS8-MEF2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BORCS8-MEF2B Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BORCS8-MEF2B Gene

Orthologs for BORCS8-MEF2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BORCS8-MEF2B Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
(Gallus gallus)
Aves -- 36
  • 46 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2586 35
(Danio rerio)
Actinopterygii mef2b 36
  • 53 (a)
(Caenorhabditis elegans)
Secernentea mef-2 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RLM1 36
  • 10 (a)
SMP1 36
  • 14 (a)
(Zea mays)
Liliopsida Zm.1104 35
Species with no ortholog for BORCS8-MEF2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for BORCS8-MEF2B Gene

Gene Tree for BORCS8-MEF2B (if available)
Gene Tree for BORCS8-MEF2B (if available)

Paralogs for BORCS8-MEF2B Gene

Paralogs for BORCS8-MEF2B Gene

genes like me logo Genes that share paralogs with BORCS8-MEF2B: view

Variants for BORCS8-MEF2B Gene

Sequence variations from dbSNP and Humsavar for BORCS8-MEF2B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256811 -- 19,172,742(+) CCAGG(A/G)GAAGG intron-variant
rs12978193 -- 19,172,468(+) CAGGG(C/T)CACCA intron-variant
rs12980269 -- 19,173,322(+) AGATC(A/G)CGCCA intron-variant
rs12980955 -- 19,172,837(+) AGCTG(C/T)GCCGC intron-variant
rs13344831 -- 19,173,175(+) ctggg(C/T)gacag intron-variant

Variation tolerance for BORCS8-MEF2B Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for BORCS8-MEF2B Gene

Disorders for BORCS8-MEF2B Gene

Relevant External Links for BORCS8-MEF2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BORCS8-MEF2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BORCS8-MEF2B Gene

Publications for BORCS8-MEF2B Gene

  1. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. (PMID: 1748287) Pollock R. … Treisman R. (Genes Dev. 1991) 3 23 67
  2. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3

Products for BORCS8-MEF2B Gene

Sources for BORCS8-MEF2B Gene