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Aliases for BORCS6 Gene

Aliases for BORCS6 Gene

  • BLOC-1 Related Complex Subunit 6 2 3 5
  • Lyspersin 2 3
  • C17orf59 3 4
  • Chromosome 17 Open Reading Frame 59 2
  • PRO2472 3

External Ids for BORCS6 Gene

Previous HGNC Symbols for BORCS6 Gene

  • C17orf59

Previous GeneCards Identifiers for BORCS6 Gene

  • GC17M008265

Summaries for BORCS6 Gene

GeneCards Summary for BORCS6 Gene

BORCS6 (BLOC-1 Related Complex Subunit 6) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BORCS6 Gene

Genomics for BORCS6 Gene

Regulatory Elements for BORCS6 Gene

Promoters for BORCS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BORCS6 on UCSC Golden Path with GeneCards custom track

Genomic Location for BORCS6 Gene

Chromosome:
17
Start:
8,188,333 bp from pter
End:
8,190,907 bp from pter
Size:
2,575 bases
Orientation:
Minus strand

Genomic View for BORCS6 Gene

Genes around BORCS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BORCS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BORCS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BORCS6 Gene

Proteins for BORCS6 Gene

  • Protein details for BORCS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GS4-CQ059_HUMAN
    Recommended name:
    Uncharacterized protein C17orf59
    Protein Accession:
    Q96GS4
    Secondary Accessions:
    • Q53HS4
    • Q9NXW8

    Protein attributes for BORCS6 Gene

    Size:
    357 amino acids
    Molecular mass:
    37226 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH09261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH18880.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH70272.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA90889.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96226.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for BORCS6 Gene

Proteomics data for BORCS6 Gene at MOPED

Post-translational modifications for BORCS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BORCS6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BORCS6 Gene

Domains & Families for BORCS6 Gene

Gene Families for BORCS6 Gene

Protein Domains for BORCS6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BORCS6: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BORCS6 Gene

Function for BORCS6 Gene

genes like me logo Genes that share phenotypes with BORCS6: view

Animal Model Products

miRNA for BORCS6 Gene

miRTarBase miRNAs that target BORCS6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BORCS6 Gene

Localization for BORCS6 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for BORCS6 Gene

Pathways & Interactions for BORCS6 Gene

SuperPathways for BORCS6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BORCS6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BORCS6 Gene

Drugs & Compounds for BORCS6 Gene

No Compound Related Data Available

Transcripts for BORCS6 Gene

mRNA/cDNA for BORCS6 Gene

(1) REFSEQ mRNAs :
(58) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BORCS6 Gene

No ASD Table

Relevant External Links for BORCS6 Gene

GeneLoc Exon Structure for
BORCS6
ECgene alternative splicing isoforms for
BORCS6

Expression for BORCS6 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BORCS6 Gene

Orthologs for BORCS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for BORCS6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C19H17orf59 35
  • 84.28 (n)
  • 81.53 (a)
C19H17orf59 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H17orf59 35
  • 81.3 (n)
  • 75.29 (a)
C17orf59 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310047M10Rik 35
  • 80.28 (n)
  • 74.37 (a)
Borcs6 16
2310047M10Rik 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf59 35
  • 99.35 (n)
  • 98.88 (a)
C17orf59 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC497934 35
  • 79.72 (n)
  • 73.24 (a)
oppossum
(Monodelphis domestica)
Mammalia C17orf59 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf59 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17orf59 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C17orf59 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9242 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11680 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6370 35
zebrafish
(Danio rerio)
Actinopterygii C8H17orf59 36
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17180 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y37E11B.3 36
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10551 36
  • 25 (a)
OneToOne
Species with no ortholog for BORCS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BORCS6 Gene

ENSEMBL:
Gene Tree for BORCS6 (if available)
TreeFam:
Gene Tree for BORCS6 (if available)

Paralogs for BORCS6 Gene

No data available for Paralogs for BORCS6 Gene

Variants for BORCS6 Gene

Sequence variations from dbSNP and Humsavar for BORCS6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs8531 -- 8,189,376(+) TCGAT(G/T)GGGGG reference, synonymous-codon
rs2233758 -- 8,188,120(+) GTTAC(C/T)GGATC downstream-variant-500B
rs2233759 -- 8,188,133(+) TGGGC(C/T)CCTGT downstream-variant-500B
rs2233760 -- 8,188,209(+) TCCCC(A/T)CGGAG downstream-variant-500B
rs2233761 -- 8,188,210(+) CCCCA(C/T)GGAGC downstream-variant-500B

Variation tolerance for BORCS6 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BORCS6 Gene

HapMap Linkage Disequilibrium report
BORCS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BORCS6 Gene

Disorders for BORCS6 Gene

Relevant External Links for BORCS6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BORCS6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BORCS6

No disorders were found for BORCS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BORCS6 Gene

Publications for BORCS6 Gene

  1. BORC, a multisubunit complex that regulates lysosome positioning. (PMID: 25898167) Pu J. … Bonifacino J.S. (Dev. Cell 2015) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1. (PMID: 26299971) Schweitzer L.D. … Sabatini D.M. (Cell Rep 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection. (PMID: 18330356) DeGrado-Warren J. … Frech G.C. (BioTechniques 2008) 3

Products for BORCS6 Gene

Sources for BORCS6 Gene

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