BORA Gene
protein-coding GIFtS: 47
GCID: GC13P073302
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bora, aurora kinase A activator(Previous name: chromosome 13 open reading frame 34 )
(Previous symbol: C13orf34)
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Aliases
for BORA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Bora, Aurora Kinase A Activator1 2 | | Aurora Borealis2 | | C13orf341 2 3 | | HsBora3 | | FLJ226241 | | Protein Aurora Borealis2 | | Chromosome 13 Open Reading Frame 341 | | HsBora3 |
Export aliases for BORA gene to outside databases |
Summaries
for BORA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BORA:
BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation,spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 (PubMed16890155)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: BORA_HUMAN, Q6PGQ7Function: Required for the activation of AURKA at the onset of mitosis
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Genomic Views
for BORA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for BORA
Other transcription factors
Search SABiosciences Chromatin IP Primers for BORA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BORA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q22.1 Ensembl cytogenetic band: 13q22.1 HGNC cytogenetic band: 13q22.1BORA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P073302: view genomic region
(about GC identifiers)
Start:
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73,302,042 bp from pter |
End:
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73,330,328 bp from pter |
Size:
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28,287 bases |
Orientation:
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plus strand |
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Proteins
for BORA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BORA_HUMAN, Q6PGQ7 (See
protein sequence)Recommended Name: Protein aurora borealis Size: 559 amino acids; 61203 Da
Subunit: Interacts with AURKA
Sequence caution: Sequence=BAB15426.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAH72713.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5W0P3 Q5W0P4 Q86YC6 Q96IW9 Q9H640Explore the universe of human proteins at neXtProt for BORA: NX_Q6PGQ7
Post-translational modifications:
Phosphorylated by AURKA1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PGQ7
BORA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079084.2
ENSEMBL proteins: ENSP00000367045 ENSP00000375082 ENSP00000367046
Human Recombinant Protein Products:
BORA Antibody Products:
Assay Products for BORA: |
Protein
Domains /
Families
for BORA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BORA for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6PGQ7ProtoNet protein and cluster: Q6PGQ7 UniProtKB/Swiss-Prot: BORA_HUMAN, Q6PGQ7Similarity: Belongs to the BORA family |
Function
for BORA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BORA_HUMAN, Q6PGQ7Function: Required for the activation of AURKA at the onset of mitosis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BORA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BORA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for BORA | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BORA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BORA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BORA |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
BORA for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for BORA:
|
Pathways & Interactions
for BORA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PLK1 signaling events | | | 2 | Cell Cycle / Checkpoint Control | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for BORA
1  BioSystems Pathway for BORA
BORA for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BORA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for BORA (Q6PGQ73 ENSP000003750824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
BORA for ontologies About GeneDecksing
|
Drugs & Compounds
for BORA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BORA
Search CenterWatch for drugs/clinical trials and news about BORA
|
Transcripts
for BORA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BORA gene: NM_024808.2 Unigene Cluster for BORA: Bora, aurora kinase A activator Hs.643464 [show with all ESTs]Unigene Representative Sequence: NM_0248085 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377814 ENST00000471712 ENST00000390667(uc010thq.1 uc001viv.1 uc010aen.1 uc010thr.1)
ENST00000464754 ENST00000377815
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BORA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BORA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for BORA | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BORA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BORA |
Additional cDNA sequence: AK026277.1 AK291496.1 AK298608.1 AK300758.1 BC007119.1 BC025367.2 BC044213.1 BC056876.1 BX648605.1 EU834129.1 12 DOTS entries: DT.444967 DT.101979623 DT.91711187 DT.100793167 DT.97858622 DT.92020251 DT.100793168 DT.314639 DT.91719636 DT.100793171 DT.75159005 DT.91971975 24/93 AceView cDNA sequences (see all 93): AA488791 AA258689 BM456283 AA598726 CR617422 CD244316 AU280312 BQ213379 CR625945 AW273920 BM763113 BC056876 BQ931825 BX464194 Z44604 Z40475 BX342880 BQ438852 BC007119 NM_024808 BM763444 BQ420511 AA642300 AK026277
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for BORA About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BORA
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Expression
for BORA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BORA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See BORA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BORA
SOURCE GeneReport for Unigene cluster: Hs.643464
SABiosciences Custom PCR Arrays for BORA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BORA
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat BORA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BORA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BORA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BORA |
Orthologs
for BORA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BORA gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for BORA (if available)
TreeFam Gene Tree for BORA (if available) |
Paralogs
for BORA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for BORA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BORA (73302042 - 73330328 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BORA: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BORA |
|
Disorders
/ Diseases
for BORA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 BORA for disorders About MalaCards
BORA for disorders About GeneDecksing
OMIM gene information: 610510
OMIM disorders: --
Export disorders for BORA gene to outside databases
|
Publications
for BORA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BORA gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with BORA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mitotic activation of the kinase Aurora-A requires its binding partner Bora. (PubMed id 16890155)1, 2, 3 Hutterer A....Knoblich J.A. (2006)
- Aurora-A and hBora join the game of Polo. (PubMed id 19487276)1, 3 Macurek L....Medema R.H. (2009)
- Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. (PubMed id 18566290)1, 3 Seki A....Fang G. (2008)
- Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. (PubMed id 18378770)1, 3 Seki A....Fang G. (2008)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PubMed id 20923822)1 Niu N....Wang L. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
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External Searches for BORA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BORA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BORA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BORA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BORA | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for BORA gene:
Search GeneIP for patents involving BORA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BORA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for BORA | | OriGene shRNA RFP for BORA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BORA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BORA | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BORA | | OriGene 3'-UTR Clone for BORA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BORA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BORA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BORA | | OriGene Custom Protein Services for BORA | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BORA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BORA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BORA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BORA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BORA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BORA |
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 |  |  |  | |
| | Antibodies & Assays for BORA |
| | | | Search Tocris compounds for BORA |
| |  |  |  |  | | | | |
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 | | | BORA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BORA |
|  |  |  | | | | ThermoFisher Antibodies for BORA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BORA |
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