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Aliases for BORA Gene

Aliases for BORA Gene

  • Bora, Aurora Kinase A Activator 2 3 5
  • C13orf34 3 4
  • Chromosome 13 Open Reading Frame 34 2
  • HsBora 4

External Ids for BORA Gene

Previous HGNC Symbols for BORA Gene

  • C13orf34

Previous GeneCards Identifiers for BORA Gene

  • GC13P073302

Summaries for BORA Gene

Entrez Gene Summary for BORA Gene

  • BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]

GeneCards Summary for BORA Gene

BORA (Bora, Aurora Kinase A Activator) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for BORA Gene

  • Required for the activation of AURKA at the onset of mitosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BORA Gene

Genomics for BORA Gene

Regulatory Elements for BORA Gene

Enhancers for BORA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BORA on UCSC Golden Path with GeneCards custom track

Promoters for BORA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BORA on UCSC Golden Path with GeneCards custom track

Genomic Location for BORA Gene

72,727,749 bp from pter
72,756,198 bp from pter
28,450 bases
Plus strand

Genomic View for BORA Gene

Genes around BORA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BORA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BORA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BORA Gene

Proteins for BORA Gene

  • Protein details for BORA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein aurora borealis
    Protein Accession:
    Secondary Accessions:
    • B4DQ30
    • Q5W0P3
    • Q5W0P4
    • Q86YC6
    • Q96IW9
    • Q9H640

    Protein attributes for BORA Gene

    559 amino acids
    Molecular mass:
    61203 Da
    Quaternary structure:
    • Interacts with AURKA.
    • Sequence=BAB15426.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BORA Gene


neXtProt entry for BORA Gene

Proteomics data for BORA Gene at MOPED

Post-translational modifications for BORA Gene

Other Protein References for BORA Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BORA (BORA)

No data available for DME Specific Peptides for BORA Gene

Domains & Families for BORA Gene

Protein Domains for BORA Gene


Suggested Antigen Peptide Sequences for BORA Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BORA family.
  • Belongs to the BORA family.
genes like me logo Genes that share domains with BORA: view

No data available for Gene Families for BORA Gene

Function for BORA Gene

Molecular function for BORA Gene

UniProtKB/Swiss-Prot Function:
Required for the activation of AURKA at the onset of mitosis.

Phenotypes for BORA Gene

genes like me logo Genes that share phenotypes with BORA: view

Animal Model Products

CRISPR Products

miRNA for BORA Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BORA Gene

Localization for BORA Gene

Subcellular locations from

Jensen Localization Image for BORA Gene COMPARTMENTS Subcellular localization image for BORA gene
Compartment Confidence
cytosol 5
nucleus 3
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BORA Gene

Pathways & Interactions for BORA Gene

genes like me logo Genes that share pathways with BORA: view

Pathways by source for BORA Gene

1 GeneTex pathway for BORA Gene
1 Cell Signaling Technology pathway for BORA Gene

SIGNOR curated interactions for BORA Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BORA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007088 regulation of mitotic nuclear division IMP 18521620
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with BORA: view

Drugs & Compounds for BORA Gene

No Compound Related Data Available

Transcripts for BORA Gene

Unigene Clusters for BORA Gene

Bora, aurora kinase A activator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BORA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP3: - - -

Relevant External Links for BORA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BORA Gene

mRNA expression in normal human tissues for BORA Gene

Protein differential expression in normal tissues from HIPED for BORA Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BORA Gene

SOURCE GeneReport for Unigene cluster for BORA Gene Hs.643464

genes like me logo Genes that share expression patterns with BORA: view

Protein tissue co-expression partners for BORA Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BORA Gene

Orthologs for BORA Gene

This gene was present in the common ancestor of chordates.

Orthologs for BORA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BORA 35
  • 87.42 (n)
  • 84.26 (a)
  • 76 (a)
(Canis familiaris)
Mammalia BORA 35
  • 90.15 (n)
  • 87.23 (a)
  • 78 (a)
(Mus musculus)
Mammalia Bora 35
  • 77.59 (n)
  • 71.48 (a)
Bora 16
Bora 36
  • 71 (a)
(Pan troglodytes)
Mammalia BORA 35
  • 99.62 (n)
  • 99.52 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Bora 35
  • 80.01 (n)
  • 74.81 (a)
(Monodelphis domestica)
Mammalia BORA 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia BORA 36
  • 67 (a)
(Gallus gallus)
Aves BORA 35
  • 68.38 (n)
  • 57.48 (a)
  • 42 (a)
(Anolis carolinensis)
Reptilia BORA 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bora 35
  • 62.1 (n)
  • 56.09 (a)
(Danio rerio)
Actinopterygii bora 35
  • 53.09 (n)
  • 42.88 (a)
bora 36
  • 39 (a)
Species with no ortholog for BORA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BORA Gene

Gene Tree for BORA (if available)
Gene Tree for BORA (if available)

Paralogs for BORA Gene

(1) SIMAP similar genes for BORA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BORA: view

No data available for Paralogs for BORA Gene

Variants for BORA Gene

Sequence variations from dbSNP and Humsavar for BORA Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs9543107 - 72,745,098(+) ACCTT(C/T)GGCTT reference, missense
rs1146858 - 72,746,552(+) AAATT(C/T)TAATG reference, missense
rs959513 -- 72,737,127(+) CTGTG(G/T)TAGAA intron-variant
rs1025814 -- 72,738,999(+) AGCAC(A/G)CAATA intron-variant
rs1440870 -- 72,750,108(+) TCTGA(A/G)GAAGA intron-variant

Variation tolerance for BORA Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for BORA Gene

Disorders for BORA Gene

Relevant External Links for BORA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BORA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BORA Gene

Publications for BORA Gene

  1. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. (PMID: 16890155) Hutterer A. … Knoblich J.A. (Dev. Cell 2006) 2 3 4 67
  2. Aurora-A and hBora join the game of Polo. (PMID: 19487276) Macurek L. … Medema R.H. (Cancer Res. 2009) 2 3
  3. Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. (PMID: 18378770) Seki A. … Fang G. (J. Cell Biol. 2008) 2 3
  4. Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. (PMID: 18566290) Seki A. … Fang G. (Science 2008) 2 3
  5. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3

Products for BORA Gene

Sources for BORA Gene