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Aliases for BORA Gene

Aliases for BORA Gene

  • Bora, Aurora Kinase A Activator 2 3
  • C13orf34 3 4 6
  • Chromosome 13 Open Reading Frame 34 2
  • Protein Aurora Borealis 3
  • HsBora 4

External Ids for BORA Gene

Previous HGNC Symbols for BORA Gene

  • C13orf34

Previous GeneCards Identifiers for BORA Gene

  • GC13P073302

Summaries for BORA Gene

Entrez Gene Summary for BORA Gene

  • BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]

GeneCards Summary for BORA Gene

BORA (Bora, Aurora Kinase A Activator) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for BORA Gene

  • Required for the activation of AURKA at the onset of mitosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BORA Gene

Genomics for BORA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BORA Gene

Start:
72,727,749 bp from pter
End:
72,756,198 bp from pter
Size:
28,450 bases
Orientation:
Plus strand

Genomic View for BORA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BORA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BORA Gene

No data available for Regulatory Elements for BORA Gene

Proteins for BORA Gene

  • Protein details for BORA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PGQ7-BORA_HUMAN
    Recommended name:
    Protein aurora borealis
    Protein Accession:
    Q6PGQ7
    Secondary Accessions:
    • B4DQ30
    • Q5W0P3
    • Q5W0P4
    • Q86YC6
    • Q96IW9
    • Q9H640

    Protein attributes for BORA Gene

    Size:
    559 amino acids
    Molecular mass:
    61203 Da
    Quaternary structure:
    • Interacts with AURKA.
    SequenceCaution:
    • Sequence=BAB15426.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BORA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BORA Gene

Proteomics data for BORA Gene at MOPED

Post-translational modifications for BORA Gene

Other Protein References for BORA Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BORA (BORA)

No data available for DME Specific Peptides for BORA Gene

Domains for BORA Gene

Protein Domains for BORA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BORA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PGQ7

UniProtKB/Swiss-Prot:

BORA_HUMAN :
  • Q6PGQ7
Family:
  • Belongs to the BORA family.
genes like me logo Genes that share domains with BORA: view

No data available for Gene Families for BORA Gene

Function for BORA Gene

Molecular function for BORA Gene

UniProtKB/Swiss-Prot Function: Required for the activation of AURKA at the onset of mitosis.

Gene Ontology (GO) - Molecular Function for BORA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18521620
GO:0019901 protein kinase binding IPI 18521620
genes like me logo Genes that share ontologies with BORA: view

Phenotypes for BORA Gene

GenomeRNAi human phenotypes for BORA:
genes like me logo Genes that share phenotypes with BORA: view

Animal Model Products

CRISPR Products

miRNA for BORA Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BORA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BORA Gene

Localization for BORA Gene

Gene Ontology (GO) - Cellular Components for BORA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0072687 meiotic spindle --
genes like me logo Genes that share ontologies with BORA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for BORA Gene

Pathways for BORA Gene

genes like me logo Genes that share pathways with BORA: view

Pathways by source for BORA Gene

1 Cell Signaling Technology pathway for BORA Gene
1 BioSystems pathway for BORA Gene

Gene Ontology (GO) - Biological Process for BORA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007088 regulation of mitotic nuclear division IMP 18521620
GO:0032880 regulation of protein localization IMP 18521620
genes like me logo Genes that share ontologies with BORA: view

Compounds for BORA Gene

(28) ApexBio Compounds for BORA Gene

Compound Action Cas Number
AMG-900 potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C [945595-80-2]
Anacardic acid selectively activate Aurora kinase A-mediated phosphorylation of histone H3 [16611-84-0]
AT9283 novel inhibitor of aurora kinase [896466-04-9]
Aurora A Inhibitor I novel, potent, and selective inhibitor of Aurora A [1158838-45-9]
AZD1152 selective Aurora B kinase inhibitor [722543-31-9]
Barasertib (AZD1152-HQPA) potent aurora kinase inhibitor [722544-51-6]
CCT129202 ATP-competitively inhibits Aurora A, Aurora B and Aurora C [942947-93-5]
CCT137690 highly selective inhibitor of Aurora A, Aurora B and Aurora C. [1095382-05-0]
CYC116 potent inhibitor of Aurora A/B. [693228-63-6]
Danusertib (PHA-739358) Pan-aurora kinase inhibitor [827318-97-8]
ENMD-2076 selective activity against Aurora A and VEGFR(Flt3). [934353-76-1]
GSK1070916 reversible and ATP-competitive inhibitor of Aurora B/C. [942918-07-2]
Hesperadin Hesperadin potently inhibits Aurora B with IC50 of 250 nM. [422513-13-1]
JNJ-7706621 dual inhibitor of cyclin-dependent kinases (CDK) and Aurora kinases [443797-96-4]
MK-5108 (VX-689) novel, potent and selective inhibitor of Aurora A kinase. [1010085-13-8]
MK-8745 potent and selective Aurora A inhibitor. [885325-71-3]
MLN8054 potent of Aurora A kinase inhibitor [869363-13-3]
MLN8237 (Alisertib) potent small-molecule inhibitor of Aurora A kinase [1028486-01-2]
PF-03814735 novel, potent and reversible inhibitor of Aurora A/B. [942487-16-3]
PHA-680632 novel and potent inhibitor of Aurora kinases. [398493-79-3]
Reversine inhibition of Aurora A and B. [656820-32-5]
SCH-1473759 novel sub-nanomolar Aurora A/B inhibitor [1094069-99-4]
SNS-314 Mesylate potent and selective inhibitor of Aurora A, Aurora B and Aurora C. [1146618-41-8]
TAK-901 novel inhibitor of Aurora A/B. [934541-31-8]
TC-A 2317 hydrochloride Potent Aurora kinase A inhibitor [1245907-03-2]
VX-680 (MK-0457,Tozasertib) potent inhibitor of pan-aurora kinase [639089-54-6]
XL228 protein kinase inhibitor targeting AURORA kinases [898280-07-4]
ZM 447439 novel, potent and selective inhibitor of Aurora kinase [331771-20-1]
genes like me logo Genes that share compounds with BORA: view

Transcripts for BORA Gene

Unigene Clusters for BORA Gene

Bora, aurora kinase A activator:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BORA

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BORA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2:
SP3: - - -
SP4:

Relevant External Links for BORA Gene

GeneLoc Exon Structure for
BORA
ECgene alternative splicing isoforms for
BORA

Expression for BORA Gene

mRNA expression in normal human tissues for BORA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BORA Gene

SOURCE GeneReport for Unigene cluster for BORA Gene Hs.643464

genes like me logo Genes that share expressions with BORA: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BORA Gene

Orthologs for BORA Gene

This gene was present in the common ancestor of chordates.

Orthologs for BORA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BORA 35
  • 99.62 (n)
  • 99.52 (a)
BORA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BORA 35
  • 87.42 (n)
  • 84.26 (a)
BORA 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BORA 35
  • 90.15 (n)
  • 87.23 (a)
BORA 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bora 35
  • 77.59 (n)
  • 71.48 (a)
Bora 16
Bora 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BORA 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BORA 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bora 35
  • 80.01 (n)
  • 74.81 (a)
chicken
(Gallus gallus)
Aves BORA 35
  • 68.38 (n)
  • 57.48 (a)
BORA 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BORA 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bora 35
  • 62.1 (n)
  • 56.09 (a)
zebrafish
(Danio rerio)
Actinopterygii bora 35
  • 53.09 (n)
  • 42.88 (a)
bora 36
  • 39 (a)
OneToOne
Species with no ortholog for BORA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BORA Gene

ENSEMBL:
Gene Tree for BORA (if available)
TreeFam:
Gene Tree for BORA (if available)

Paralogs for BORA Gene

Selected SIMAP similar genes for BORA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BORA: view

No data available for Paralogs for BORA Gene

Variants for BORA Gene

Sequence variations from dbSNP and Humsavar for BORA Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs959513 -- 72,737,127(+) CTGTG(G/T)TAGAA intron-variant
rs1025814 -- 72,738,999(+) AGCAC(A/G)CAATA intron-variant
rs1146858 - 72,746,552(+) AAATT(C/T)TAATG reference, missense
rs1372003 -- 72,748,097(+) AACAT(C/G)TAACA intron-variant
rs1440870 -- 72,750,108(+) TCTGA(A/G)GAAGA intron-variant

Relevant External Links for BORA Gene

HapMap Linkage Disequilibrium report
BORA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BORA Gene

Disorders for BORA Gene

No disorders were found for BORA Gene.

No data available for UniProtKB/Swiss-Prot for BORA Gene

Publications for BORA Gene

  1. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. (PMID: 16890155) Hutterer A. … Knoblich J.A. (Dev. Cell 2006) 2 3 4
  2. Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. (PMID: 18378770) Seki A. … Fang G. (J. Cell Biol. 2008) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for BORA Gene

Sources for BORA Gene

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