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BORA Gene

protein-coding   GIFtS: 47
GCID: GC13P073302

Bora, Aurora Kinase A Activator

(Previous name: chromosome 13 open reading frame 34)
(Previous symbol: C13orf34)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bora, Aurora Kinase A Activator1 2
C13orf341 2 3 5
Chromosome 13 Open Reading Frame 341
Protein Aurora Borealis2
HsBora3

External Ids:    HGNC: 247241   Entrez Gene: 798662   Ensembl: ENSG000001361227   OMIM: 6105105   UniProtKB: Q6PGQ73   

Export aliases for BORA gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BORA Gene:
BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome
maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 (PubMed
16890155)).(supplied by OMIM, Mar 2008)

GeneCards Summary for BORA Gene:
BORA (bora, aurora kinase A activator) is a protein-coding gene. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot: BORA_HUMAN, Q6PGQ7
Function: Required for the activation of AURKA at the onset of mitosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for BORA
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for BORA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BORA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22.1   Ensembl cytogenetic band:  13q22.1   HGNC cytogenetic band: 13q22.1

BORA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BORA gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P073302:  view genomic region     (about GC identifiers)

Start:
73,302,042 bp from pter      End:
73,330,336 bp from pter
Size:
28,295 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BORA_HUMAN, Q6PGQ7 (See protein sequence)
Recommended Name: Protein aurora borealis  
Size: 559 amino acids; 61203 Da
Subunit: Interacts with AURKA
Sequence caution: Sequence=BAB15426.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAH72713.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5W0P3 Q5W0P4 Q86YC6 Q96IW9 Q9H640

Explore the universe of human proteins at neXtProt for BORA: NX_Q6PGQ7

Explore proteomics data for BORA at MOPED

Post-translational modifications: 

  • Phosphorylated by AURKA1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BORA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273675.1  NP_001273676.1  NP_079084.3  

    ENSEMBL proteins: 
     ENSP00000367045   ENSP00000375082   ENSP00000367046  
    Reactome Protein details: Q6PGQ7

    BORA Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for BORA (3 products) 

     
    antibodies-online peptides for BORA

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    antibodies-online antibodies for BORA (33 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR023252 Aurora_borealis_protien

    Graphical View of Domain Structure for InterPro Entry Q6PGQ7

    ProtoNet protein and cluster: Q6PGQ7

    UniProtKB/Swiss-Prot: BORA_HUMAN, Q6PGQ7
    Similarity: Belongs to the BORA family


    Find genes that share domains with BORA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BORA_HUMAN, Q6PGQ7
    Function: Required for the activation of AURKA at the onset of mitosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18521620
    GO:0019901protein kinase binding IPI18521620
         
    Find genes that share ontologies with BORA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BORA:
     Increased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BORA
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    miRNA
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    miRTarBase miRNAs that target BORA:
    hsa-mir-193b-3p (MIRT016532), hsa-mir-181d-5p (MIRT041165), hsa-mir-192-5p (MIRT026923), hsa-mir-215-5p (MIRT024771)

    Block miRNA regulation of human, mouse, rat BORA using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidBORA 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with BORA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BORA About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Regulation of PLK1 Activity at G2/M Transition0.77
    Mitotic G2-G2/M phases0.69
    G2/M Transition0.70
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    3Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    4PLK1 signaling events
    PLK1 signaling events


    Find genes that share SuperPaths with BORA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for BORA
        Cell Cycle / Checkpoint Control

    1 BioSystems Pathway for BORA
        PLK1 signaling events

    1 Reactome Pathway for BORA
        Regulation of PLK1 Activity at G2/M Transition


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BORA
    Interactions:

        Search GeneGlobe Interaction Network for BORA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for BORA (Q6PGQ73 ENSP000003750824) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FEZ1Q996893, ENSP000002789194I2D: score=4 STRING: ENSP00000278919
    BTRCQ9Y2973, ENSP000003592064I2D: score=2 STRING: ENSP00000359206
    AURKAO149653, ENSP000002169114I2D: score=1 STRING: ENSP00000216911
    CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
    SKP1P632083, ENSP000002314874I2D: score=1 STRING: ENSP00000231487
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007088regulation of mitosis IMP18521620
    GO:0032880regulation of protein localization IMP18521620

    Find genes that share ontologies with BORA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for BORA (see all 28)     About this table
    CompoundAction CAS #
    AMG-900potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C[945595-80-2]
    Anacardic acidselectively activate Aurora kinase A-mediated phosphorylation of histone H3[16611-84-0]
    AT9283novel inhibitor of aurora kinase[896466-04-9]
    Aurora A Inhibitor Inovel, potent, and selective inhibitor of Aurora A[1158838-45-9]
    AZD1152selective Aurora B kinase inhibitor[722543-31-9]
    Barasertib (AZD1152-HQPA)potent aurora kinase inhibitor[722544-51-6]
    CCT129202ATP-competitively inhibits Aurora A, Aurora B and Aurora C[942947-93-5]
    CCT137690highly selective inhibitor of Aurora A, Aurora B and Aurora C[1095382-05-0]
    CYC116potent inhibitor of Aurora A/B[693228-63-6]
    Danusertib (PHA-739358)potent small-molecule inhibitor of aurora B kinase[827318-97-8]

    Browse Tocris compounds for BORA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BORA gene (3 alternative transcripts): 
    NM_001286746.1  NM_001286747.1  NM_024808.3  

    Unigene Cluster for BORA:

    Bora, aurora kinase A activator
    Hs.643464  [show with all ESTs]
    Unigene Representative Sequence: NM_024808
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377814 ENST00000471712 ENST00000390667(uc010thq.1 uc001viv.1 uc010aen.1 uc010thr.1)
    ENST00000464754 ENST00000377815
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat BORA

    Additional mRNA sequence: 

    AK026277.1 AK291496.1 AK298608.1 AK300758.1 BC007119.1 BC025367.2 BC044213.1 BC056876.1 
    BX648605.1 EU834129.1 

    12 DOTS entries:

    DT.444967  DT.101979623  DT.91711187  DT.100793167  DT.97858622  DT.92020251  DT.100793168  DT.314639 
    DT.91719636  DT.100793171  DT.75159005  DT.91971975 

    Selected AceView cDNA sequences (see all 93):

    AK026277 CR617422 AA642300 BM456283 CR625945 BX380430 BC056876 AA258689 
    AA598726 CD244316 BM763444 BQ213379 BC007119 BX342880 AW273920 BQ420511 
    NM_024808 BQ438852 BX464194 AA489007 BQ931825 Z40475 Z44604 AA488791 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BORA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                    -     -     -                                                   
    SP4:                                                                                    


    ECgene alternative splicing isoforms for BORA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BORA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BORA Expression
    About this image

    BORA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BORA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643464
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BORA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bora1 , 5 RIKEN cDNA 6720463M24 gene5
    bora, aurora kinase A activator1
    77.59(n)1
    71.48(a)1
      14 (49.23 cM)5
    777441  NM_175265.41  NP_780474.11 
     990463775 
    chicken
    (Gallus gallus)
    Aves BORA1 bora, aurora kinase A activator 68.38(n)
    57.48(a)
      769298  NM_001079741.2  NP_001073209.1 
    lizard
    (Anolis carolinensis)
    Reptilia BORA6
    bora, aurora kinase A activator
    53(a)
    1 ↔ 1
    3(88625470-88638102)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU910417.12   -- 75.05(n)    BU910417.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570655872   -- 75.74(n)    57065587 


    ENSEMBL Gene Tree for BORA (if available)
    TreeFam Gene Tree for BORA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BORA gene
    1 SIMAP similar gene for BORA using alignment to 3 protein entries:     BORA_HUMAN (see all proteins):
    C13orf34

    Find genes that share paralogs with BORA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BORA (see all 525)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs672278671,2
    C--54024401(+) GTGAT-/AAAGAGT 1 -- int11Minor allele frequency- AA:0.00NA 2
    rs1891905741,2
    --73304022(+) TGATAC/TGATTA 1 -- int10--------
    rs79981701,2
    C,F,A,H--73304030(+) TTAGTG/ACTTAG 1 -- int116Minor allele frequency- A:0.06NS EA NA WA CSA 677
    rs93181201,2
    C,F,A,H--73304037(+) TTAGGG/ACAATA 1 -- int112Minor allele frequency- A:0.16NA WA CSA EA 375
    rs1918882051,2
    --73304137(+) CATGTA/TGGCCA 1 -- int10--------
    rs1154858751,2
    C,F--73304229(+) TGCCCG/AGGCCA 1 -- int11Minor allele frequency- A:0.06WA 118
    rs1496013921,2
    --73304359(+) ATACAA/GGTTTT 1 -- int10--------
    rs1829435861,2
    --73304482(+) TAAAAA/CTAAAT 1 -- int10--------
    rs1113919441,2
    C--73304539(+) CTTGCG/ATTTTT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1874893961,2
    --73304545(+) TTTTTA/TGGACT 1 -- int10--------

    HapMap Linkage Disequilibrium report for BORA (73302042 - 73330336 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BORA: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BORA
    DNA2.0 Custom Variant and Variant Library Synthesis for BORA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610510    OMIM disorders: --


    Find genes that share disorders with BORA           About GenesLikeMe


    Export disorders for BORA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BORA gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with BORA)
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    1. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. (PubMed id 16890155)1, 2, 3 Hutterer A....Knoblich J.A. (Dev. Cell 2006)
    2. Aurora-A and hBora join the game of Polo. (PubMed id 19487276)1, 3 Macurek L....Medema R.H. (Cancer Res. 2009)
    3. Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. (PubMed id 18566290)1, 3 Seki A....Fang G. (Science 2008)
    4. Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. (PubMed id 18378770)1, 3 Seki A....Fang G. (J. Cell Biol. 2008)
    5. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein. (PubMed id 23592782)1 Qin B....Lou Z. (J. Biol. Chem. 2013)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PubMed id 20923822)1 Niu N....Wang L. (Genome Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79866 HGNC: 24724 AceView: FLJ22624 Ensembl:ENSG00000136122 euGenes: HUgn79866
    ECgene: BORA H-InvDB: BORA

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BORA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for BORA gene:
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    GeneCards and IP:
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