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Aliases for BOP1 Gene

Aliases for BOP1 Gene

  • Block Of Proliferation 1 2 3
  • Block Of Proliferation 1 Protein 4
  • KIAA0124 4

External Ids for BOP1 Gene

Previous GeneCards Identifiers for BOP1 Gene

  • GC08M143100
  • GC08M145571
  • GC08M145090
  • GC08M145422
  • GC08M145490
  • GC08M145456
  • GC08M140600
  • GC08M145486

Summaries for BOP1 Gene

GeneCards Summary for BOP1 Gene

BOP1 (Block Of Proliferation 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot for BOP1 Gene

  • Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Gene Wiki entry for BOP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOP1 Gene

Genomics for BOP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BOP1 Gene

Chromosome:
8
Start:
144,262,046 bp from pter
End:
144,291,438 bp from pter
Size:
29,393 bases
Orientation:
Minus strand

Genomic View for BOP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BOP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOP1 Gene

Proteins for BOP1 Gene

  • Protein details for BOP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14137-BOP1_HUMAN
    Recommended name:
    Ribosome biogenesis protein BOP1
    Protein Accession:
    Q14137
    Secondary Accessions:
    • Q969Z6
    • Q96IS8
    • Q96Q25
    • Q9BSA7
    • Q9BVM0

    Protein attributes for BOP1 Gene

    Size:
    746 amino acids
    Molecular mass:
    83630 Da
    Quaternary structure:
    • Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.

    Alternative splice isoforms for BOP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BOP1 Gene

Proteomics data for BOP1 Gene at MOPED

Post-translational modifications for BOP1 Gene

  • Ubiquitination at Lys 391
  • Modification sites at PhosphoSitePlus

Other Protein References for BOP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BOP1 Gene

Domains & Families for BOP1 Gene

Gene Families for BOP1 Gene

Suggested Antigen Peptide Sequences for BOP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14137

UniProtKB/Swiss-Prot:

BOP1_HUMAN :
  • Belongs to the WD repeat BOP1/ERB1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat BOP1/ERB1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with BOP1: view

Function for BOP1 Gene

Molecular function for BOP1 Gene

UniProtKB/Swiss-Prot Function:
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
UniProtKB/Swiss-Prot Induction:
By MYC.

Gene Ontology (GO) - Molecular Function for BOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16043514
GO:0043021 ribonucleoprotein complex binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BOP1: view
genes like me logo Genes that share phenotypes with BOP1: view

miRNA for BOP1 Gene

miRTarBase miRNAs that target BOP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BOP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for BOP1 Gene

Localization for BOP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOP1 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BOP1 Gene COMPARTMENTS Subcellular localization image for BOP1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for BOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus --
GO:0030529 ribonucleoprotein complex IDA 18809582
GO:0030687 preribosome, large subunit precursor IBA --
GO:0070545 PeBoW complex IDA 16043514
genes like me logo Genes that share ontologies with BOP1: view

Pathways & Interactions for BOP1 Gene

SuperPathways for BOP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP 17353269
GO:0006364 rRNA processing --
GO:0008283 cell proliferation NAS 16043514
GO:0042254 ribosome biogenesis NAS 16043514
genes like me logo Genes that share ontologies with BOP1: view

No data available for Pathways by source and SIGNOR curated interactions for BOP1 Gene

Drugs & Compounds for BOP1 Gene

No Compound Related Data Available

Transcripts for BOP1 Gene

Unigene Clusters for BOP1 Gene

Block of proliferation 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BOP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BOP1 Gene

No ASD Table

Relevant External Links for BOP1 Gene

GeneLoc Exon Structure for
BOP1
ECgene alternative splicing isoforms for
BOP1

Expression for BOP1 Gene

mRNA expression in normal human tissues for BOP1 Gene

mRNA differential expression in normal tissues according to GTEx for BOP1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for BOP1 Gene

This gene is overexpressed in Lung (14.1), Breast (8.7), Blymphocyte (7.5), and Liver (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BOP1 Gene



SOURCE GeneReport for Unigene cluster for BOP1 Gene Hs.645279

genes like me logo Genes that share expression patterns with BOP1: view

Protein tissue co-expression partners for BOP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BOP1 Gene

Orthologs for BOP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BOP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BOP1 35
  • 85.5 (n)
  • 88.56 (a)
dog
(Canis familiaris)
Mammalia BOP1 35
  • 84.31 (n)
  • 85.49 (a)
mouse
(Mus musculus)
Mammalia Bop1 35
  • 82.9 (n)
  • 86.74 (a)
Bop1 16
chimpanzee
(Pan troglodytes)
Mammalia BOP1 35
  • 95.56 (n)
  • 94.31 (a)
rat
(Rattus norvegicus)
Mammalia Bop1 35
  • 82.44 (n)
  • 86.87 (a)
chicken
(Gallus gallus)
Aves BOP1 35
  • 76.81 (n)
  • 76.01 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bop1 35
  • 70.43 (n)
  • 71.74 (a)
Str.1855 35
African clawed frog
(Xenopus laevis)
Amphibia bop1-prov 35
zebrafish
(Danio rerio)
Actinopterygii bop1 35
  • 70.92 (n)
  • 74.16 (a)
wufc64d06 35
fruit fly
(Drosophila melanogaster)
Insecta EG:52C10.1 37
  • 53 (a)
CG5033 35
  • 59.41 (n)
  • 54.88 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta BOP1_ANOGA 35
  • 59.81 (n)
  • 54.47 (a)
worm
(Caenorhabditis elegans)
Secernentea Y48B6A.1 37
  • 46 (a)
CELE_Y48B6A.1 35
  • 54.3 (n)
  • 48.23 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR101C 35
  • 51.94 (n)
  • 45.81 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F26653g 35
  • 46.26 (n)
  • 44.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERB1 35
  • 46.24 (n)
  • 44.19 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40360 35
  • 48.24 (n)
  • 43.32 (a)
rice
(Oryza sativa)
Liliopsida Os07g0435400 35
  • 49.89 (n)
  • 45.92 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3764 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03321 35
  • 53.27 (n)
  • 45.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4F6.13c 35
  • 46.73 (n)
  • 47.24 (a)
Species with no ortholog for BOP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BOP1 Gene

ENSEMBL:
Gene Tree for BOP1 (if available)
TreeFam:
Gene Tree for BOP1 (if available)

Paralogs for BOP1 Gene

(2) SIMAP similar genes for BOP1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with BOP1: view

No data available for Paralogs for BOP1 Gene

Variants for BOP1 Gene

Sequence variations from dbSNP and Humsavar for BOP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4074678 -- 144,277,497(-) GAGGG(G/T)TCGGG intron-variant
rs4074679 -- 144,277,190(-) GGGCC(G/T)GAGAG intron-variant
rs4265220 -- 144,284,234(+) TTGAG(A/G)TTTTG intron-variant
rs4557742 -- 144,284,347(+) AATTT(G/T)CCCCA intron-variant
rs4977198 -- 144,271,235(+) GCCCC(C/T)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BOP1 Gene

Variant ID Type Subtype PubMed ID
dgv7940n71 CNV Loss 21882294
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
dgv7955n71 CNV Loss 21882294
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7957n71 CNV Loss 21882294
esv30003 CNV Loss 17803354
dgv7958n71 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
esv989584 CNV Deletion 20482838
nsv891827 CNV Loss 21882294
nsv8396 CNV Gain 18304495
dgv7960n71 CNV Loss 21882294
dgv7961n71 CNV Loss 21882294
nsv891832 CNV Gain+Loss 21882294
nsv891836 CNV Loss 21882294
nsv891838 CNV Gain 21882294
nsv891840 CNV Loss 21882294
esv2738055 CNV Deletion 23290073
esv2738056 CNV Deletion 23290073
esv2738057 CNV Deletion 23290073
esv2253218 CNV Deletion 18987734
esv2738058 CNV Deletion 23290073
esv3547 CNV Deletion 18987735
nsv891841 CNV Loss 21882294
esv2738059 CNV Deletion 23290073
esv29857 CNV Gain 19812545
esv2738060 CNV Deletion 23290073
esv2675243 CNV Deletion 23128226
esv2738061 CNV Deletion 23290073
nsv396397 CNV Loss 16902084
nsv824804 CNV Gain 20364138

Variation tolerance for BOP1 Gene

Gene Damage Index Score: 0.21; 4.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BOP1 Gene

HapMap Linkage Disequilibrium report
BOP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BOP1 Gene

Disorders for BOP1 Gene

Relevant External Links for BOP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BOP1
genes like me logo Genes that share disorders with BOP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOP1 Gene

Publications for BOP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex. (PMID: 25825154) Kellner M. … Eick D. (Exp. Cell Res. 2015) 67
  5. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 67

Products for BOP1 Gene

Sources for BOP1 Gene

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