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Aliases for BOP1 Gene

Aliases for BOP1 Gene

  • Block Of Proliferation 1 2 3 5
  • Block Of Proliferation 1 Protein 4
  • KIAA0124 4

External Ids for BOP1 Gene

Previous GeneCards Identifiers for BOP1 Gene

  • GC08M143100
  • GC08M145571
  • GC08M145090
  • GC08M145422
  • GC08M145490
  • GC08M145456
  • GC08M140600
  • GC08M145486

Summaries for BOP1 Gene

GeneCards Summary for BOP1 Gene

BOP1 (Block Of Proliferation 1) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot for BOP1 Gene

  • Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Gene Wiki entry for BOP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOP1 Gene

Genomics for BOP1 Gene

Regulatory Elements for BOP1 Gene

Enhancers for BOP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F144322 1.1 ENCODE 14.5 -33.6 -33598 5.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 KLF13 C8orf82 BOP1 ZNF517 C8orf33 ARHGAP39 DGAT1 KIFC2 MIR6848 ENSG00000254690
GH08F144313 1 ENCODE 12.3 -23.8 -23824 2.9 ARID4B SIN3A ZNF48 GLIS2 GATA2 KLF13 REST SSRP1 SMARCA4 GLIS1 MAF1 BOP1 HSF1 VPS28 ENSG00000254690 MIR6848
GH08F144290 1 ENCODE 12.1 -2.0 -1965 6.0 ATF1 PKNOX1 ARID4B SIN3A YY1 ELK1 GATA2 ZNF143 NFYC ZHX2 DGAT1 MIR6848 ENSG00000254690 BOP1 TONSL-AS1 SCX PARP10 SPATC1 HSF1 GC08P144309
GH08F144002 1.1 Ensembl ENCODE 10.2 +286.9 286935 3.5 HDAC1 PKNOX1 SAP130 MAX CEBPG THRB RAD21 YY1 GATA3 SCRT2 PLEC WDR97 EXOSC4 ENSG00000255224 MIR6847 MIR661 GPAA1 CYC1 MAF1 SHARPIN
GH08F144184 0.9 Ensembl ENCODE 11.9 +106.1 106127 1.4 HDGF PKNOX1 BHLHE40 RELA ARID3A IKZF1 CTBP2 NBN SPI1 ZC3H3 BOP1 HSF1 ENSG00000254690 DGAT1 MIR6848 WDR97 ZNF251 ENSG00000255224 PIR45617
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BOP1 on UCSC Golden Path with GeneCards custom track

Promoters for BOP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001446429 -62 2601 ATF1 PKNOX1 ARID4B SIN3A YY1 ELK1 GATA2 ZNF143 NFYC ZHX2

Genomic Location for BOP1 Gene

Chromosome:
8
Start:
144,262,046 bp from pter
End:
144,291,438 bp from pter
Size:
29,393 bases
Orientation:
Minus strand

Genomic View for BOP1 Gene

Genes around BOP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOP1 Gene

Proteins for BOP1 Gene

  • Protein details for BOP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14137-BOP1_HUMAN
    Recommended name:
    Ribosome biogenesis protein BOP1
    Protein Accession:
    Q14137
    Secondary Accessions:
    • Q969Z6
    • Q96IS8
    • Q96Q25
    • Q9BSA7
    • Q9BVM0

    Protein attributes for BOP1 Gene

    Size:
    746 amino acids
    Molecular mass:
    83630 Da
    Quaternary structure:
    • Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:16043514, PubMed:16738141, PubMed:17189298, PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome (By similarity). The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27 (PubMed:25825154).
    • Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:16043514, PubMed:16738141, PubMed:17189298, PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome (By similarity). The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27 (PubMed:25825154).

    Alternative splice isoforms for BOP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BOP1 Gene

Post-translational modifications for BOP1 Gene

  • Ubiquitination at Lys 391
  • Modification sites at PhosphoSitePlus

Other Protein References for BOP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BOP1 Gene

Domains & Families for BOP1 Gene

Gene Families for BOP1 Gene

Suggested Antigen Peptide Sequences for BOP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14137

UniProtKB/Swiss-Prot:

BOP1_HUMAN :
  • Belongs to the WD repeat BOP1/ERB1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat BOP1/ERB1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with BOP1: view

Function for BOP1 Gene

Molecular function for BOP1 Gene

UniProtKB/Swiss-Prot Function:
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
UniProtKB/Swiss-Prot Induction:
By MYC.

Gene Ontology (GO) - Molecular Function for BOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16043514
GO:0043021 ribonucleoprotein complex binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BOP1: view
genes like me logo Genes that share phenotypes with BOP1: view

Animal Model Products

miRNA for BOP1 Gene

miRTarBase miRNAs that target BOP1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOP1 Gene

Localization for BOP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOP1 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BOP1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for BOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0030529 intracellular ribonucleoprotein complex IDA 18809582
genes like me logo Genes that share ontologies with BOP1: view

Pathways & Interactions for BOP1 Gene

genes like me logo Genes that share pathways with BOP1: view

Gene Ontology (GO) - Biological Process for BOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP 17353269
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA --
GO:0006364 rRNA processing IEA,TAS --
GO:0008283 cell proliferation NAS 16043514
genes like me logo Genes that share ontologies with BOP1: view

No data available for SIGNOR curated interactions for BOP1 Gene

Transcripts for BOP1 Gene

Unigene Clusters for BOP1 Gene

Block of proliferation 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BOP1 Gene

No ASD Table

Relevant External Links for BOP1 Gene

GeneLoc Exon Structure for
BOP1
ECgene alternative splicing isoforms for
BOP1

Expression for BOP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BOP1 Gene

mRNA differential expression in normal tissues according to GTEx for BOP1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for BOP1 Gene

This gene is overexpressed in Lung (14.1), Breast (8.7), Blymphocyte (7.5), and Liver (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BOP1 Gene



Protein tissue co-expression partners for BOP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BOP1 Gene:

BOP1

SOURCE GeneReport for Unigene cluster for BOP1 Gene:

Hs.645279
genes like me logo Genes that share expression patterns with BOP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BOP1 Gene

Orthologs for BOP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BOP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BOP1 34
  • 95.56 (n)
cow
(Bos Taurus)
Mammalia BOP1 34
  • 85.5 (n)
dog
(Canis familiaris)
Mammalia BOP1 34
  • 84.31 (n)
mouse
(Mus musculus)
Mammalia Bop1 34 16
  • 82.9 (n)
rat
(Rattus norvegicus)
Mammalia Bop1 34
  • 82.44 (n)
chicken
(Gallus gallus)
Aves BOP1 34
  • 76.81 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia bop1 34
  • 70.43 (n)
Str.1855 34
African clawed frog
(Xenopus laevis)
Amphibia bop1-prov 34
zebrafish
(Danio rerio)
Actinopterygii bop1 34
  • 70.92 (n)
wufc64d06 34
African malaria mosquito
(Anopheles gambiae)
Insecta BOP1_ANOGA 34
  • 59.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5033 34
  • 59.41 (n)
EG:52C10.1 36
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y48B6A.1 34
  • 54.3 (n)
Y48B6A.1 36
  • 46 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR101C 34
  • 51.94 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F26653g 34
  • 46.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERB1 34
  • 46.24 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G40360 34
  • 48.24 (n)
rice
(Oryza sativa)
Liliopsida Os07g0435400 34
  • 49.89 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03321 34
  • 53.27 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4F6.13c 34
  • 46.73 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3764 34
Species where no ortholog for BOP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BOP1 Gene

ENSEMBL:
Gene Tree for BOP1 (if available)
TreeFam:
Gene Tree for BOP1 (if available)

Paralogs for BOP1 Gene

(2) SIMAP similar genes for BOP1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with BOP1: view

No data available for Paralogs for BOP1 Gene

Variants for BOP1 Gene

Sequence variations from dbSNP and Humsavar for BOP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10088505 -- 144,270,862(+) GCACC(C/T)TGGGC intron-variant
rs10093866 -- 144,290,137(+) gtgga(C/T)cacct intron-variant, upstream-variant-2KB
rs111232249 -- 144,290,122(+) GGGAG(A/G)CTGAG intron-variant, upstream-variant-2KB
rs111239986 -- 144,281,093(+) ACTTT(A/C)ATACC intron-variant
rs111271654 -- 144,270,678(+) CCTGC(A/G)GCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BOP1 Gene

Variant ID Type Subtype PubMed ID
esv3544397 CNV deletion 23714750
esv3547 CNV loss 18987735
nsv1025071 CNV gain 25217958
nsv1112185 CNV deletion 24896259
nsv1112480 CNV deletion 24896259
nsv1130165 CNV deletion 24896259
nsv1152990 CNV deletion 26484159
nsv396397 CNV deletion 16902084
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv824804 CNV gain 20364138
nsv950822 CNV deletion 24416366
esv29857 CNV gain 19812545
esv2738060 CNV deletion 23290073
esv2738059 CNV deletion 23290073
esv2738058 CNV deletion 23290073
esv2738057 CNV deletion 23290073
esv2738055 CNV deletion 23290073
esv2675243 CNV deletion 23128226
esv2253218 CNV deletion 18987734
dgv12434n54 CNV loss 21841781

Variation tolerance for BOP1 Gene

Gene Damage Index Score: 0.21; 4.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BOP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BOP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BOP1 Gene

Disorders for BOP1 Gene

Relevant External Links for BOP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BOP1

No disorders were found for BOP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOP1 Gene

Publications for BOP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 64
  2. DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex. (PMID: 25825154) Kellner M. … Eick D. (Exp. Cell Res. 2015) 3 4 64
  3. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. (PMID: 17353269) Rohrmoser M. … Eick D. (Mol. Cell. Biol. 2007) 3 4 64
  4. Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. (PMID: 16738141) Grimm T. … Eick D. (Nucleic Acids Res. 2006) 3 4 64
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64

Products for BOP1 Gene

Sources for BOP1 Gene

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