Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BOP1 Gene

protein-coding   GIFtS: 55
GCID: GC08M145486

Block Of Proliferation 1

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Block Of Proliferation 11 2
Block Of Proliferation 1 Protein2 3
KIAA01243 5
Block Of Proliferation 1 Pseudogene2
Ribosome Biogenesis Protein BOP12

External Ids:    HGNC: 155191   Entrez Gene: 232462   Ensembl: ENSG000001707277   OMIM: 6105965   UniProtKB: Q141373   

Export aliases for BOP1 gene to outside databases

Previous GC identifers: GC08M143100 GC08M145571 GC08M145090 GC08M145422 GC08M145490 GC08M145456 GC08M140600


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for BOP1 Gene:
BOP1 (block of proliferation 1) is a protein-coding gene. An important paralog of this gene is ENSG00000204775.

UniProtKB/Swiss-Prot: BOP1_HUMAN, Q14137
Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and
formation of the 60S ribosome

Gene Wiki entry for BOP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the BOP1 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBOP1 promoter sequence
   Search Chromatin IP Primers for BOP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BOP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

BOP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BOP1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145486:  view genomic region     (about GC identifiers)

Start:
145,486,055 bp from pter      End:
145,515,120 bp from pter
Size:
29,066 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BOP1_HUMAN, Q14137 (See protein sequence)
Recommended Name: Ribosome biogenesis protein BOP1  
Size: 746 amino acids; 83630 Da
Subunit: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts
directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome
Secondary accessions: Q969Z6 Q96IS8 Q9BSA7 Q9BVM0

Explore the universe of human proteins at neXtProt for BOP1: NX_Q14137

Explore proteomics data for BOP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys339, Lys391
  • Modification sites at PhosphoSitePlus

  • See BOP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056016.1  
    ENSEMBL proteins: 
     ENSP00000304151   ENSP00000432017   ENSP00000435997   ENSP00000436398  

    BOP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BOP1
    OriGene Protein Over-expression Lysate for BOP1
    OriGene MassSpec for BOP1
    OriGene Custom Protein Services for BOP1
    GenScript Custom Purified and Recombinant Proteins Services for BOP1
    Novus Biologicals BOP1 Protein
    Novus Biologicals BOP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BOP1

     
    Search eBioscience for Proteins for BOP1 

    BOP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BOP1
    Novus Biologicals BOP1 Antibodies
    Abcam antibodies for BOP1
    Cloud-Clone Corp. Antibodies for BOP1
    ThermoFisher Antibodies for BOP1
    LSBio Antibodies in human, mouse, rat for BOP1

    BOP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BOP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BOP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BOP1
    Cloud-Clone Corp. CLIAs for BOP1
    Search eBioscience for ELISAs for BOP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR012953 BOP1_N_dom
     IPR028598 BOP1/Erb1
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q14137

    ProtoNet protein and cluster: Q14137

    1 Blocks protein domain: IPB012953 BOP1

    UniProtKB/Swiss-Prot: BOP1_HUMAN, Q14137
    Similarity: Belongs to the WD repeat BOP1/ERB1 family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with BOP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BOP1_HUMAN, Q14137
    Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and
    formation of the 60S ribosome
    Induction: By MYC

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16043514
    GO:0043021ribonucleoprotein complex binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with BOP1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BOP1:
     Decreased viability  Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BOP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BOP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BOP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BOP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target BOP1:
    hsa-mir-296-3p (MIRT038393), hsa-mir-324-5p (MIRT043142)

    Block miRNA regulation of human, mouse, rat BOP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate BOP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BOP1
    Predesigned siRNA for gene silencing in human, mouse, rat BOP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BOP1

    Clone
    Products:
         
    OriGene clones in human, mouse for BOP1 (see all 7)
    OriGene ORF clones in mouse, rat for BOP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BOP1 (NM_015201)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BOP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BOP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BOP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for BOP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BOP1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12591) for BOP1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BOP1_HUMAN, Q14137: Nucleus, nucleolus. Nucleus, nucleoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus ----
    GO:0030529ribonucleoprotein complex IDA18809582
    GO:0030687preribosome, large subunit precursor IEA--
    GO:0070545PeBoW complex IDA16043514

    Find genes that share ontologies with BOP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BOP1
    Interactions:

        GeneGlobe Interaction Network for BOP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BOP1 (Q141371, 2, 3 ENSP000003041514) via UniProtKB, MINT, STRING, and/or I2D (see all 231)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000463maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP17353269
    GO:0000466maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA--
    GO:0006364rRNA processing ----
    GO:0008283cell proliferation NAS16043514
    GO:0042254ribosome biogenesis NAS16043514

    Find genes that share ontologies with BOP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BOP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BOP1 gene: 
    NM_015201.3  

    Unigene Cluster for BOP1:

    Block of proliferation 1
    Hs.645279  [show with all ESTs]
    Unigene Representative Sequence: NM_015201
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307404(uc003zbr.1) ENST00000526471 ENST00000529245 ENST00000526552
    ENST00000530355 ENST00000525016 ENST00000529231 ENST00000524861 ENST00000533125

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BOP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate BOP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BOP1
    Predesigned siRNA for gene silencing in human, mouse, rat BOP1
    Clone
    Products:
         
    OriGene clones in human, mouse for BOP1 (see all 7)
    OriGene ORF clones in mouse, rat for BOP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BOP1 (NM_015201)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BOP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BOP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BOP1
    OriGene qSTAR qPCR primer pairs in human, mouse for BOP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BOP1
      QuantiTect SYBR Green Assays in human, mouse, rat BOP1
      QuantiFast Probe-based Assays in human, mouse, rat BOP1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12591) for BOP1 

    Additional mRNA sequence: 

    AB060694.1 AK024840.1 AK290677.1 AK293719.1 AK310015.1 AK315612.1 BC001086.2 BC005160.2 
    BC007274.1 BC013787.1 BC013980.2 BC017674.2 BC073813.1 BC098446.1 D50914.1 

    8 DOTS entries:

    DT.100790510  DT.100790506  DT.100790500  DT.112989  DT.95163462  DT.92453052  DT.95163456  DT.95163458 

    Selected AceView cDNA sequences (see all 383):

    BC005160 BC007274 BX400424 BU145291 AI356401 CA309887 BG680241 CD366287 
    BC001086 BQ649889 BI913089 BQ876898 NM_015201 BM456753 AA458650 BX334580 
    AA127054 BQ642571 BQ061984 BM850565 BQ068594 BG282993 BE739899 BU183173 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BOP1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                                                        -                                                         
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for BOP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BOP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTACAATG
    BOP1 Expression
    About this image

    BOP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BOP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.645279
        Custom PCR Arrays for BOP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BOP1
    OriGene qSTAR qPCR primer pairs in human, mouse for BOP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BOP1
    QuantiTect SYBR Green Assays in human, mouse, rat BOP1
    QuantiFast Probe-based Assays in human, mouse, rat BOP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BOP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BOP1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bop11 , 5 block of proliferation 11, 5 82.9(n)1
    86.74(a)1
      15 (35.91 cM)5
    121811  NM_013481.11  NP_038509.11 
     764529965 
    chicken
    (Gallus gallus)
    Aves BOP11 block of proliferation 1 76.81(n)
    76.01(a)
      425985  XM_004950475.1  XP_004950532.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    79(a)
    1 → many
    AAWZ02039979(21-6726)
    African clawed frog
    (Xenopus laevis)
    Amphibia bop1-prov2 block of proliferation 1 78.55(n)    BC044074.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc64d062 wufc64d06 75.51(n)   325279  BG985514.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:52C10.13
    CG50331
    transcription factor3
    CG50331
    53(a)3
    59.41(n)1
    54.88(a)1
      54E93
    370361  NM_137426.31  NP_611270.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48B6A.13
    CELE_Y48B6A.11
    CELE_Y48B6A.11 46(a)3
    54.3(n)1
    48.23(a)1
      II(14151241-14154259)3
    1750691  NM_064555.41  NP_496956.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERB1(YMR049C)4
    ERB11
    Constituent of 66S pre-ribosomal particles, forms a more4
    ERB11
    46.24(n)1
    44.19(a)1
      13(370517-368094)4
    8550681, 4  NP_013764.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G403601 AT2G40360 48.24(n)
    43.32(a)
      818629  NM_129596.3  NP_181567.3 
    rice
    (Oryza sativa)
    Liliopsida Os07g04354001 Os07g0435400 49.89(n)
    45.92(a)
      4343071  NM_001066037.1  NP_001059502.1 


    ENSEMBL Gene Tree for BOP1 (if available)
    TreeFam Gene Tree for BOP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BOP1 gene
    ENSG000002047752  
    2 SIMAP similar genes for BOP1 using alignment to 9 protein entries:     BOP1_HUMAN (see all proteins):
    KM-PA-2    WDR18

    Find genes that share paralogs with BOP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BOP1 (see all 356)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70168571,2
    A--140600981(+) GACGCA/GAAGAG 3 L F mis1 ese30--------
    rs1159884331,2
    C--145494298(+) AGAGAC/TGTCAG 1 -- int10--------
    rs1468859631,2
    --145494835(+) AGGGG-/CCCCCA 1 -- int10--------
    rs1160540661,2
    C--145494850(+) GCACCC/TTGGGC 1 -- int10--------
    rs1481381401,2
    C--145495068(+) GAGCC-/CCGG  
            
    CCGGC
    1 -- int10--------
    rs1147444211,2
    C--145495223(+) GCCCCC/TTTCCC 1 -- int10--------
    rs1162953261,2
    C--145495578(+) TCTGTC/TGAAGT 1 -- int10--------
    rs1159831151,2
    C--145495662(+) GGCCCC/TGGCGC 1 -- int10--------
    rs1387011431,2
    C--145497364(+) CCCAG-/ACT   
       CCAGA
    CCCCA
    1 -- int10--------
    rs1151744071,2
    C--145497378(+) TCCAGA/GCCCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for BOP1 (145486055 - 145515120 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BOP1 (see all 34):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2253218CNV Deletion18987734
    esv2738055CNV Deletion23290073
    esv989584CNV Deletion20482838
    esv2675243CNV Deletion23128226
    esv2738060CNV Deletion23290073
    esv2738061CNV Deletion23290073
    esv2738059CNV Deletion23290073
    esv3547CNV Deletion18987735
    esv2738057CNV Deletion23290073
    esv2738058CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BOP1
    DNA2.0 Custom Variant and Variant Library Synthesis for BOP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610596    OMIM disorders: --


    Find genes that share disorders with BOP1           About GenesLikeMe


    Export disorders for BOP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BOP1 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with BOP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    2. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. (PubMed id 17353269)1, 2 Rohrmoser M.... Eick D. (Mol. Cell. Biol. 2007)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. (PubMed id 16738141)1, 2 Grimm T.... Eick D. (Nucleic Acids Res. 2006)
    5. Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. (PubMed id 16043514)1, 2 Hoelzel M.... Eick D. (J. Cell Biol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23246 HGNC: 15519 AceView: BOP1 Ensembl:ENSG00000170727 euGenes: HUgn23246
    ECgene: BOP1 H-InvDB: BOP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0124

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BOP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BOP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BOP1 gene:
    Search GeneIP for patents involving BOP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for BOP1  
     OriGene qPCR primer pairs and template standards for BOP1   OriGene Protein Over-expression Lysate for BOP1  
     OriGene MassSpec something-or-other for BOP1   OriGene clones in human, mouse for BOP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for BOP1   OriGene Purified Protein for BOP1  
     OriGene ORF clones in mouse, rat for BOP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BOP1   OriGene Custom Protein Services for BOP1  

     
     
     Block miRNA regulation of human, mouse, rat BOP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BOP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BOP1 Predesigned siRNA for gene silencing in human, mouse, rat BOP1
     QuantiFast Probe-based Assays in human, mouse, rat BOP1 QuantiTect SYBR Green Assays in human, mouse, rat BOP1
     Custom PCR Arrays for BOP1 Search Chromatin IP Primers for BOP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BOP1  GeneGlobe Interaction Network for BOP1
     Regulatory tfbs in BOP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for BOP1 GenScript cDNA clones with any tag delivered in your preferred vector for BOP1
     GenScript Custom Assay Services for BOP1 GenScript Custom overexpressing Cell Line Services for BOP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BOP1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BOP1 antibodies
     BOP1 proteins
     BOP1 lysates
     Antibodies for BOP1
     See all of Abcam's Antibodies, Kits and Proteins for BOP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for BOP1
     Antibodies for BOP1
     ELISAs for BOP1
     CLIAs for BOP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for BOP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BOP1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for BOP1
     SwitchGear Promoter luciferase reporter plasmids for BOP1
     ThermoFisher Antibodies for BOP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BOP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BOP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BOP1
     LSBio Antibodies in human, mouse, rat for BOP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for BOP1
      Search eBioscience for proteins for BOP1
      Search eBioscience for elisas for BOP1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BOP1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4