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Aliases for BOP Gene

Aliases for BOP Gene

  • Polymicrogyria, Bilateral Occipital 3
  • BH3-Only Protein 4
  • C22orf29 4

External Ids for BOP Gene

Previous GeneCards Identifiers for BOP Gene

  • GC02P087964
  • GC02P088660

Summaries for BOP Gene

GeneCards Summary for BOP Gene

BOP (Polymicrogyria, Bilateral Occipital) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BOP Gene

  • Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOP Gene

Genomics for BOP Gene

Genomic Location for BOP Gene

Unknown strand

Genomic View for BOP Gene

Cytogenetic band:

No data available for Regulatory Elements and RefSeq DNA sequence for BOP Gene

Proteins for BOP Gene

  • Protein details for BOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Bop
    Protein Accession:
    Secondary Accessions:
    • A8K5E7
    • D3DX21
    • Q6MZM8
    • Q6N000
    • Q9H7A0

    Protein attributes for BOP Gene

    364 amino acids
    Molecular mass:
    39299 Da
    Quaternary structure:
    • Interacts (via BH3 domain) with VDAC1. Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK.
    • Sequence=BAB14998.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for BOP Gene

Proteomics data for BOP Gene at MOPED

Post-translational modifications for BOP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BOP Gene

Domains for BOP Gene

Protein Domains for BOP Gene


Graphical View of Domain Structure for InterPro Entry



  • Q7L3V2
  • The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.
genes like me logo Genes that share domains with BOP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for BOP Gene

Function for BOP Gene

Molecular function for BOP Gene

UniProtKB/Swiss-Prot Function:
Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BOP Gene

Localization for BOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOP Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for BOP Gene

Pathways for BOP Gene

SuperPathways for BOP Gene

No Data Available

Interacting Proteins for BOP Gene

Gene Ontology (GO) - Biological Process for BOP Gene


No data available for Pathways by source for BOP Gene

Transcripts for BOP Gene

Alternative Splicing Database (ASD) splice patterns (SP) for BOP Gene

No ASD Table

No data available for mRNA/cDNA for BOP Gene

Expression for BOP Gene

mRNA Expression by UniProt/SwissProt for BOP Gene

Tissue specificity: Ubiquitously expressed.

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for BOP Gene

Orthologs for BOP Gene

No data available for Orthologs and Evolution for BOP Gene

Paralogs for BOP Gene

Selected SIMAP similar genes for BOP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BOP: view

No data available for Paralogs for BOP Gene

Variants for BOP Gene

Sequence variations from dbSNP and Humsavar for BOP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_034590 -
VAR_034591 -

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for BOP Gene

Disorders for BOP Gene

Relevant External Links for BOP

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for BOP Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for BOP Gene

Publications for BOP Gene

  1. The variations of BOP gene in hypertrophic cardiomyopathy. (PMID: 20693124) Abaci N. … Erginel Unaltuna N. (Anadolu Kardiyol Derg 2010) 3
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for BOP Gene

Sources for BOP Gene

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