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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BOLL Gene

protein-coding   GIFtS: 52
GCID: GC02M198591

Bol, Boule-Like (Drosophila)

(Previous name: bol (Drosophila boule homolog)-like)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bol, Boule-Like (Drosophila)1 2
BOULE2 3 5
Bol (Drosophila Boule Homolog)-Like1
Protein Boule-Like2

External Ids:    HGNC: 142731   Entrez Gene: 660372   Ensembl: ENSG000001524307   OMIM: 6061655   UniProtKB: Q8N9W63   

Export aliases for BOLL gene to outside databases

Previous GC identifers: GC02M196791 GC02M197304 GC02M198555 GC02M198794 GC02M198417 GC02M198299 GC02M190443


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BOLL Gene:
This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein
which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or
DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen
(azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two
alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for BOLL Gene: 
BOLL (bol, boule-like (Drosophila)) is a protein-coding gene. Diseases associated with BOLL include urethral obstruction, and azoospermia. GO annotations related to this gene include RNA binding and translation activator activity. An important paralog of this gene is DAZ1.

UniProtKB/Swiss-Prot: BOLL_HUMAN, Q8N9W6
Function: Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the
3'-UTR of mRNAs and regulating their translation (By similarity)

Gene Wiki entry for BOLL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BOLL gene promoter:
         Max   SRY   Pax-6   NF-kappaB   LCR-F1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBOLL promoter sequence
   Search SABiosciences Chromatin IP Primers for BOLL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BOLL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33

BOLL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BOLL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M198591:  view genomic region     (about GC identifiers)

Start:
198,591,603 bp from pter      End:
198,651,486 bp from pter
Size:
59,884 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BOLL_HUMAN, Q8N9W6 (See protein sequence)
Recommended Name: Protein boule-like  
Size: 283 amino acids; 31301 Da
Subunit: Interacts with DAZ1 and DAZL
Subcellular location: Cytoplasm
Secondary accessions: Q0JW32 Q53T62 Q969U3
Alternative splicing: 4 isoforms:  Q8N9W6-1   Q8N9W6-2   Q8N9W6-3   Q8N9W6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BOLL: NX_Q8N9W6

Explore proteomics data for BOLL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N9W6

  • BOLL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BOLL Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001271287.1  NP_001271290.1  NP_001271291.1  NP_149019.1  NP_932074.1  

    ENSEMBL proteins: 
     ENSP00000397711   ENSP00000376116   ENSP00000314792   ENSP00000416911   ENSP00000396099  
     ENSP00000282278  

    Human Recombinant Protein Products for BOLL: 
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    OriGene Protein Over-expression Lysate for BOLL
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for BOLL 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11390979

    BOLL for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q8N9W6

    ProtoNet protein and cluster: Q8N9W6

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: BOLL_HUMAN, Q8N9W6
    Similarity: Belongs to the RRM DAZ family
    Similarity: Contains 1 DAZ-like domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    BOLL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BOLL_HUMAN, Q8N9W6
    Function: Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the
    3'-UTR of mRNAs and regulating their translation (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI16001084
    GO:0008494translation activator activity IDA16001084
         
    BOLL for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Boll):
     cellular  endocrine/exocrine gland  reproductive system 

    BOLL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bolltm1Eyx for BOLL

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BOLL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BOLL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BOLL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BOLL 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BOLL
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate BOLL (see all 29):
    hsa-miR-1287 hsa-miR-3938 hsa-miR-3673 hsa-miR-3146 hsa-miR-202 hsa-miR-513c hsa-miR-132 hsa-miR-320e
    SwitchGear 3'UTR luciferase reporter plasmidBOLL 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of BOLL

    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BOLL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BOLL

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for BOLL (Q8N9W63 ENSP000003147924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAZ1Q9NQZ33, ENSP000003845734I2D: score=2 STRING: ENSP00000384573
    DAZ4Q86SG33I2D: score=1 
    --ENSP000003717424STRING: ENSP00000371742
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007126meiosis IDA12499397
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--
    GO:0045948positive regulation of translational initiation IDA16001084

    BOLL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BOLL

    Search CenterWatch for drugs/clinical trials and news about BOLL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BOLL gene (5 alternative transcripts): 
    NM_001284358.1  NM_001284361.1  NM_001284362.1  NM_033030.5  NM_197970.2  

    Unigene Cluster for BOLL:

    Bol, boule-like (Drosophila)
    Hs.169797  [show with all ESTs]
    Unigene Representative Sequence: NM_033030
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430004(uc002uur.2 uc002uuu.1) ENST00000392296(uc002uus.2)
    ENST00000321801(uc002uut.2 uc010zha.1) ENST00000434976 ENST00000468827
    ENST00000433157 ENST00000486206 ENST00000282278
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BOLL
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate BOLL (see all 29):
    hsa-miR-1287 hsa-miR-3938 hsa-miR-3673 hsa-miR-3146 hsa-miR-202 hsa-miR-513c hsa-miR-132 hsa-miR-320e
    SwitchGear 3'UTR luciferase reporter plasmidBOLL 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for BOLL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BOLL
    Clone
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    OriGene ORF clones in mouse, rat for BOLL
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    GenScript: all cDNA clones in your preferred vector (see all 2): BOLL (NM_033030)
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    Sirion Biotech Customized lentivirus for stable overexpression of BOLL 
                         Customized lentivirus expression plasmids for stable overexpression of BOLL 
    Primer
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    OriGene qPCR primer pairs and template standards for BOLL
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BOLL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BOLL

    Additional mRNA sequence: 

    AF272858.1 AK058099.1 AK093453.1 AK097795.1 AK098824.1 AK302817.1 AM295005.1 BC033674.1 

    3 DOTS entries:

    DT.92068142  DT.99930769  DT.99927331 

    24/49 AceView cDNA sequences (see all 49):

    AK097795 AK058099 AX748137 NM_197970 AK098824 AK093453 BC033674 NM_033030 
    BF059752 BP368992 BG719506 BG723619 BG717107 BV206620 AA401600 BG722029 
    BI561445 BP369388 BG772456 BX113083 AI381516 BG721681 AA954512 BM560393 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for BOLL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                                          
    SP2:        -     -                                         -                                 
    SP3:              -                                         -                                 


    ECgene alternative splicing isoforms for BOLL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BOLL expression in normal human tissues (normalized intensities)      BOLL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BOLL Expression
    About this image


    BOLL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             testis ; cells in seminiferus ducts   
             sperm   
     
     Brain (Nervous System)
             Cerebellum

    See BOLL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BOLL

    SOURCE GeneReport for Unigene cluster: Hs.169797

    UniProtKB/Swiss-Prot: BOLL_HUMAN, Q8N9W6
    Tissue specificity: Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial
    cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BOLL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BOLL gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Boll1 , 5 bol, boule-like (Drosophila)1, 5 91.09(n)1
    92.01(a)1
      1 (28.08 cM)5
    753881  NM_029267.31  NP_083543.21 
     552486585 
    chicken
    (Gallus gallus)
    Aves BOLL1 bol, boule-like (Drosophila) 79.48(n)
    77.22(a)
      424061  XM_421917.3  XP_421917.3 
    lizard
    (Anolis carolinensis)
    Reptilia BOLL6
    bol, boule-like (Drosophila)
    77(a)
    1 ↔ 1
    GL343436.1(550470-587018)
    fruit fly
    (Drosophila melanogaster)
    Insecta bol1 , 3 regulation of translation RNA binding3
    boule1
    55(a)3
    48.62(n)1
    44.2(a)1
      66F53
    390491  NM_079265.31  NP_523989.11 
    worm
    (Caenorhabditis elegans)
    Secernentea daz-16
    DAZ protein 1
    14(a)
    1 → many
    II(5456305-5458616)


    ENSEMBL Gene Tree for BOLL (if available)
    TreeFam Gene Tree for BOLL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BOLL gene
    DAZ12  DAZL2  DAZ32  DAZ42  DAZ22  
    18/22 SIMAP similar genes for BOLL using alignment to 4 protein entries:     BOLL_HUMAN (see all proteins) (see all similar genes):
    DAZ2    DAZ3    DAZ4    CIRBP    RBMY1C    RBMY1E
    RBMY1J    RBMY1A1    DAZL    RBMX    HNRNPA1    MSI2
    HNRNPD    PABPC1    PABPC4    SNRNP70    RBM38    CELF4

    BOLL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/993 SNPs in BOLL are shown (see all 993)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826906021,2
    --198591107(+) GGCCAA/GAGTAG 2 -- int10--------
    rs1426112011,2
    --198591109(+) CCAAAA/GTAGGA 2 -- int10--------
    rs133968731,2
    H--198591288(+) gagccA/Ctgatc 2 -- int14Minor allele frequency- C:0.00NS EA 420
    rs2017764501,2
    C--198591423(+) CATTT-/ATTCAG
            
    ATTGT
    2 -- int10--------
    rs1890001251,2
    --198591494(+) GCATAC/TGTATA 2 -- int10--------
    rs1459632371,2
    --198591550(+) TGTATG/TCATAT 2 -- int10--------
    rs1157367021,2
    C,F--198591558(+) TATAAT/CCTATA 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1398846911,2
    --198591581(+) AAACAC/GACTTG 2 -- int10--------
    rs22721661,2
    C,F,H--198591684(-) TTTTGA/GTTTTC 2 -- ut315Minor allele frequency- G:0.00NS EA NA 420
    rs1841717941,2
    --198591687(+) AATCAA/GAACAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for BOLL (198591603 - 198651486 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BOLL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516368CNV Loss19592680
    nsv460016CNV Gain19166990
    nsv875698CNV Gain21882294
    nsv834506CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BOLL
    DNA2.0 Custom Variant and Variant Library Synthesis for BOLL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606165    OMIM disorders: --

    8 diseases for BOLL:    About MalaCards
    urethral obstruction    azoospermia    urethritis    spondylosis
    intracranial aneurysm    male infertility    infertility    neuronitis

    1 disease from the University of Copenhagen DISEASES database for BOLL:
    Actinomycosis

    BOLL for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for BOLL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azoospermia 87.5 9 8657280 (1), 12499397 (1), 18550751 (1), 9486791 (1) (see all 9)
    infertility male 77.2 6 10819768 (1), 9294855 (1), 9321470 (1), 10857750 (1) (see all 6)
    sterility male 58.7 1 9486791 (1)
    oligozoospermia 56.6 1 8968756 (1)

    Genetic Association Database (GAD): BOLL
    Human Genome Epidemiology (HuGE) Navigator: BOLL (9 documents)

    Export disorders for BOLL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BOLL gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with BOLL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PubMed id 11390979)1, 2, 3 Xu E.Y.... Reijo Pera R.A. (2001)
    2. Association of three isoforms of the meiotic BOULE gene with spermatogenic failure in infertile men. (PubMed id 17114206)1, 2, 9 Kostova E....Gromoll J. (2007)
    3. Phenotypic Expression of Partial AZFc Deletions is Independent of the Variations in DAZL and BOULE in a Han Population. (PubMed id 19342699)1, 4 Chen P....Yang Y. (2009)
    4. Susceptibility loci for intracranial aneurysm in European and Japanese populations. (PubMed id 18997786)1, 4 Bilguvar K....GA1nel M. (2008)
    5. Mutations in the human BOULE gene are not a major cause of impaired spermatogenesis. (PubMed id 15705409)1, 4 Westerveld G.H....Lombardi M.P. (2005)
    6. The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells. (PubMed id 16001084)1, 3 Collier B....Gray N.K. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Mutation analysis of the BOULE gene in men with non-obstructive azoospermia: identification of a novel polymorphic variant in the black population. (PubMed id 15379971)1, 4 Lepretre A.C....Bienvenu T. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Posttranscriptional regulation of CDC25A by BOLL is a conserved fertility mechanism essential for human spermatogenesis. (PubMed id 19417033)1, 9 Lin Y.M....Cheng Y.S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 66037 HGNC: 14273 AceView: BOLL Ensembl:ENSG00000152430 euGenes: HUgn66037
    ECgene: BOLL H-InvDB: BOLL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BOLL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BOLL gene:
    Search GeneIP for patents involving BOLL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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