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Aliases for BOLL Gene

Aliases for BOLL Gene

  • Boule Homolog, RNA Binding Protein 2 3 5
  • Boule-Like RNA Binding Protein 2 3
  • BOULE 3 4
  • Bol (Drosophila Boule Homolog)-Like 2
  • Boule-Like RNA-Binding Protein 3
  • Bol, Boule-Like (Drosophila) 2
  • Bol, Boule-Like 3

External Ids for BOLL Gene

Previous GeneCards Identifiers for BOLL Gene

  • GC02M196791
  • GC02M197304
  • GC02M198555
  • GC02M198794
  • GC02M198417
  • GC02M198299
  • GC02M198591
  • GC02M190443

Summaries for BOLL Gene

Entrez Gene Summary for BOLL Gene

  • This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BOLL Gene

BOLL (Boule Homolog, RNA Binding Protein) is a Protein Coding gene. Diseases associated with BOLL include Azoospermia and Male Infertility. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is DAZL.

UniProtKB/Swiss-Prot for BOLL Gene

  • Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3-UTR of mRNAs and regulating their translation (By similarity).

Gene Wiki entry for BOLL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOLL Gene

Genomics for BOLL Gene

Regulatory Elements for BOLL Gene

Enhancers for BOLL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BOLL on UCSC Golden Path with GeneCards custom track

Promoters for BOLL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BOLL on UCSC Golden Path with GeneCards custom track

Genomic Location for BOLL Gene

197,726,879 bp from pter
197,786,762 bp from pter
59,884 bases
Minus strand

Genomic View for BOLL Gene

Genes around BOLL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOLL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOLL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOLL Gene

Proteins for BOLL Gene

  • Protein details for BOLL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein boule-like
    Protein Accession:
    Secondary Accessions:
    • B4DZA4
    • Q0JW32
    • Q53T62
    • Q969U3

    Protein attributes for BOLL Gene

    283 amino acids
    Molecular mass:
    31301 Da
    Quaternary structure:
    • Interacts with DAZ1 and DAZL.

    Alternative splice isoforms for BOLL Gene


neXtProt entry for BOLL Gene

Proteomics data for BOLL Gene at MOPED

Post-translational modifications for BOLL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BOLL Gene

Domains & Families for BOLL Gene

Gene Families for BOLL Gene

Protein Domains for BOLL Gene

Suggested Antigen Peptide Sequences for BOLL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DAZ-like domain.
  • Belongs to the RRM DAZ family.
  • Contains 1 DAZ-like domain.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM DAZ family.
genes like me logo Genes that share domains with BOLL: view

Function for BOLL Gene

Molecular function for BOLL Gene

UniProtKB/Swiss-Prot Function:
Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3-UTR of mRNAs and regulating their translation (By similarity).

Gene Ontology (GO) - Molecular Function for BOLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with BOLL: view
genes like me logo Genes that share phenotypes with BOLL: view

Animal Models for BOLL Gene

MGI Knock Outs for BOLL:

Animal Model Products

miRNA for BOLL Gene

miRTarBase miRNAs that target BOLL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BOLL Gene

Localization for BOLL Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOLL Gene


Subcellular locations from

Jensen Localization Image for BOLL Gene COMPARTMENTS Subcellular localization image for BOLL gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for BOLL Gene

Pathways & Interactions for BOLL Gene

SuperPathways for BOLL Gene

No Data Available

Gene Ontology (GO) - Biological Process for BOLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045948 positive regulation of translational initiation IDA 16001084
genes like me logo Genes that share ontologies with BOLL: view

No data available for Pathways by source and SIGNOR curated interactions for BOLL Gene

Drugs & Compounds for BOLL Gene

No Compound Related Data Available

Transcripts for BOLL Gene

Unigene Clusters for BOLL Gene

Bol, boule-like (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BOLL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP2: - - -
SP3: - -

Relevant External Links for BOLL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BOLL Gene

mRNA expression in normal human tissues for BOLL Gene

mRNA differential expression in normal tissues according to GTEx for BOLL Gene

This gene is overexpressed in Testis (x47.6) and Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for BOLL Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BOLL Gene

SOURCE GeneReport for Unigene cluster for BOLL Gene Hs.169797

mRNA Expression by UniProt/SwissProt for BOLL Gene

Tissue specificity: Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.
genes like me logo Genes that share expression patterns with BOLL: view

Protein tissue co-expression partners for BOLL Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BOLL Gene

Orthologs for BOLL Gene

This gene was present in the common ancestor of animals.

Orthologs for BOLL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BOLL 35
  • 93.9 (n)
  • 94.24 (a)
  • 94 (a)
(Canis familiaris)
Mammalia BOLL 35
  • 94.91 (n)
  • 94.79 (a)
  • 93 (a)
(Mus musculus)
Mammalia Boll 35
  • 91.09 (n)
  • 92.01 (a)
Boll 16
Boll 36
  • 90 (a)
(Pan troglodytes)
Mammalia BOLL 35
  • 99.66 (n)
  • 99.66 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC100911373 35
  • 90.86 (n)
  • 92.01 (a)
(Monodelphis domestica)
Mammalia BOLL 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia BOLL 36
  • 90 (a)
(Gallus gallus)
Aves BOLL 35
  • 78.25 (n)
  • 74.74 (a)
(Anolis carolinensis)
Reptilia BOLL 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta bol 37
  • 55 (a)
bol 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea daz-1 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for BOLL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for BOLL Gene

Gene Tree for BOLL (if available)
Gene Tree for BOLL (if available)

Paralogs for BOLL Gene

Paralogs for BOLL Gene

genes like me logo Genes that share paralogs with BOLL: view

Variants for BOLL Gene

Sequence variations from dbSNP and Humsavar for BOLL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs700641 -- 197,734,509(-) catac(A/G)tgtgc intron-variant
rs700642 -- 197,736,006(-) GTTCG(A/C)TGGTC intron-variant
rs700643 -- 197,736,646(-) CCAAA(C/T)GTCCT intron-variant
rs700644 -- 197,740,520(-) TAATC(C/T)AGTTA intron-variant
rs700645 -- 197,740,790(-) cctca(C/T)cccaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BOLL Gene

Variant ID Type Subtype PubMed ID
nsv834506 CNV Gain 17160897
nsv516368 CNV Loss 19592680
nsv875698 CNV Gain 21882294
nsv460016 CNV Gain 19166990

Variation tolerance for BOLL Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BOLL Gene

Disorders for BOLL Gene

MalaCards: The human disease database

(3) MalaCards diseases for BOLL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • spermatogenic failure
male infertility
  • infertility male
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards
Search BOLL in MalaCards View complete list of genes associated with diseases

Relevant External Links for BOLL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BOLL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BOLL Gene

Publications for BOLL Gene

  1. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PMID: 11390979) Xu E.Y. … Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 67
  2. Posttranscriptional regulation of CDC25A by BOLL is a conserved fertility mechanism essential for human spermatogenesis. (PMID: 19417033) Lin Y.M. … Cheng Y.S. (J. Clin. Endocrinol. Metab. 2009) 3 23
  3. Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation. (PMID: 19865085) Kee K. … Reijo Pera R.A. (Nature 2009) 3 23
  4. Association of three isoforms of the meiotic BOULE gene with spermatogenic failure in infertile men. (PMID: 17114206) Kostova E. … Gromoll J. (Mol. Hum. Reprod. 2007) 3 23
  5. The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells. (PMID: 16001084) Collier B. … Gray N.K. (EMBO J. 2005) 2 3

Products for BOLL Gene

Sources for BOLL Gene