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Aliases for BOLA2B Gene

Aliases for BOLA2B Gene

  • BolA Family Member 2B 2 3 5
  • BolA-Like Protein 2 Member B 3
  • BolA Homolog 2B (E. Coli) 2
  • BolA-Like 2B (E. Coli) 2
  • BolA-Like Protein 2B 3
  • BolA Homolog 2B 3
  • BOLA2 BOLA2B 4
  • BOLA2A 4
  • BOLA2 3

External Ids for BOLA2B Gene

Previous GeneCards Identifiers for BOLA2B Gene

  • GC16U900518
  • GC16M030112

Summaries for BOLA2B Gene

Entrez Gene Summary for BOLA2B Gene

  • This gene is located within a region of a segmental duplication on chromosome 16 and is identical to BOLA2 (bolA family member 2). The product of this gene belongs to a family of proteins that are widely conserved and may be involved in iron maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for BOLA2B Gene

BOLA2B (BolA Family Member 2B) is a Protein Coding gene. An important paralog of this gene is BOLA2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOLA2B Gene

Genomics for BOLA2B Gene

Regulatory Elements for BOLA2B Gene

Promoters for BOLA2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BOLA2B on UCSC Golden Path with GeneCards custom track

Genomic Location for BOLA2B Gene

30,192,934 bp from pter
30,194,306 bp from pter
1,373 bases
Minus strand

Genomic View for BOLA2B Gene

Genes around BOLA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOLA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOLA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOLA2B Gene

Proteins for BOLA2B Gene

  • Protein details for BOLA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BolA-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A1L454
    • A7YDY3

    Protein attributes for BOLA2B Gene

    86 amino acids
    Molecular mass:
    10117 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH22832.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI30402.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI30404.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37533.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37535.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI44689.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BOLA2B Gene


neXtProt entry for BOLA2B Gene

Proteomics data for BOLA2B Gene at MOPED

Post-translational modifications for BOLA2B Gene

  • Ubiquitination at Lys 43 and Lys 73
  • Modification sites at PhosphoSitePlus

Other Protein References for BOLA2B Gene

No data available for DME Specific Peptides for BOLA2B Gene

Domains & Families for BOLA2B Gene

Protein Domains for BOLA2B Gene


Suggested Antigen Peptide Sequences for BOLA2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BolA/IbaG family.
  • Belongs to the BolA/IbaG family.
genes like me logo Genes that share domains with BOLA2B: view

No data available for Gene Families for BOLA2B Gene

Function for BOLA2B Gene

Phenotypes for BOLA2B Gene

GenomeRNAi human phenotypes for BOLA2B:
genes like me logo Genes that share phenotypes with BOLA2B: view

Animal Model Products

CRISPR Products

miRNA for BOLA2B Gene

miRTarBase miRNAs that target BOLA2B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOLA2B Gene

Localization for BOLA2B Gene

Subcellular locations from

Jensen Localization Image for BOLA2B Gene COMPARTMENTS Subcellular localization image for BOLA2B gene
Compartment Confidence
extracellular 5
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BOLA2B Gene

Pathways & Interactions for BOLA2B Gene

SuperPathways for BOLA2B Gene

No Data Available

Interacting Proteins for BOLA2B Gene

Gene Ontology (GO) - Biological Process for BOLA2B Gene


No data available for Pathways by source and SIGNOR curated interactions for BOLA2B Gene

Drugs & Compounds for BOLA2B Gene

No Compound Related Data Available

Transcripts for BOLA2B Gene

mRNA/cDNA for BOLA2B Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BOLA2B Gene

No ASD Table

Relevant External Links for BOLA2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BOLA2B Gene

mRNA expression in normal human tissues for BOLA2B Gene

Protein differential expression in normal tissues from HIPED for BOLA2B Gene

This gene is overexpressed in Lavage (18.1) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BOLA2B Gene

SOURCE GeneReport for Unigene cluster for BOLA2B Gene Hs.647333

genes like me logo Genes that share expression patterns with BOLA2B: view

Protein tissue co-expression partners for BOLA2B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BOLA2B Gene

Orthologs for BOLA2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BOLA2B Gene

Organism Taxonomy Gene Similarity Type Details
(Rattus norvegicus)
Mammalia LOC100363408 35
  • 85.27 (n)
  • 81.4 (a)
(Bos Taurus)
Mammalia -- 36
  • 90 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
(Mus musculus)
Mammalia Bola2 36
  • 87 (a)
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
(Danio rerio)
Actinopterygii BOLA2B 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33672 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRA2 38
Species with no ortholog for BOLA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOLA2B Gene

Gene Tree for BOLA2B (if available)
Gene Tree for BOLA2B (if available)

Paralogs for BOLA2B Gene

Paralogs for BOLA2B Gene

(1) SIMAP similar genes for BOLA2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BOLA2B: view

Variants for BOLA2B Gene

Structural Variations from Database of Genomic Variants (DGV) for BOLA2B Gene

Variant ID Type Subtype PubMed ID
dgv845e1 CNV Complex 17122850
nsv905711 CNV Gain 21882294
esv29892 CNV Gain 19812545
esv2714183 CNV Deletion 23290073
nsv498862 CNV Loss 21111241
nsv820959 CNV Duplication 20802225
nsv9426 CNV Gain 18304495
nsv905720 CNV Loss 21882294
dgv846e1 CNV Complex 17122850
dgv847e1 CNV Complex 17122850
nsv905723 CNV Loss 21882294
nsv9431 CNV Gain+Loss 18304495
esv22245 CNV Gain 19812545
nsv821543 CNV Duplication 20802225
nsv471387 CNV Duplication 19718026
nsv471388 CNV Duplication 19718026

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for BOLA2B Gene

Disorders for BOLA2B Gene

Relevant External Links for BOLA2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BOLA2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOLA2B Gene

Publications for BOLA2B Gene

  1. Solution structure of a BolA-like protein from Mus musculus. (PMID: 14718656) Kasai T. … Yokoyama S. (Protein Sci. 2004) 2 3 67
  2. Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway. (PMID: 26613676) Banci L. … Muzzioli R. (J. Am. Chem. Soc. 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Human glutaredoxin 3 forms [2Fe-2S]-bridged complexes with human BolA2. (PMID: 22309771) Li H. … Outten C.E. (Biochemistry 2012) 3
  5. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PMID: 22623428) Byron A. … Humphries M.J. (Proteomics 2012) 3

Products for BOLA2B Gene

Sources for BOLA2B Gene