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Aliases for BOLA2 Gene

Aliases for BOLA2 Gene

  • BolA Family Member 2 2 3
  • BOLA2A 3 4
  • BolA-Like Protein 2 Member A 3
  • BolA Homolog 2 (E. Coli) 2
  • BolA-Like 2 (E. Coli) 2
  • BolA-Like Protein 2 3
  • BolA Homolog 2 3
  • BOLA2 BOLA2B 4
  • BolA-Like 2 3
  • My016 3

External Ids for BOLA2 Gene

Previous GeneCards Identifiers for BOLA2 Gene

  • GC16U900508
  • GC16M029363
  • GC16M029364
  • GC16M029454
  • GC16M027866

Summaries for BOLA2 Gene

Entrez Gene Summary for BOLA2 Gene

  • This gene is located within a region of a segmental duplication on chromosome 16p. The product of this gene belongs to the eukaryotic subfamily of the BolA-like proteins. This gene encodes the BolA-like protein 2. The BolA-like proteins are widely conserved from prokaryotes to eukaryotes, and these proteins seem to be involved in cell proliferation or cell-cycle regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for BOLA2 Gene

BOLA2 (BolA Family Member 2) is a Protein Coding gene. An important paralog of this gene is BOLA2B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOLA2 Gene

Genomics for BOLA2 Gene

Regulatory Elements for BOLA2 Gene

Genomic Location for BOLA2 Gene

Start:
29,453,593 bp from pter
End:
29,454,964 bp from pter
Size:
1,372 bases
Orientation:
Minus strand

Genomic View for BOLA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BOLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOLA2 Gene

Proteins for BOLA2 Gene

  • Protein details for BOLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3K6-BOLA2_HUMAN
    Recommended name:
    BolA-like protein 2
    Protein Accession:
    Q9H3K6
    Secondary Accessions:
    • A1L454
    • A7YDY3

    Protein attributes for BOLA2 Gene

    Size:
    86 amino acids
    Molecular mass:
    10117 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH22832.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI30402.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI30404.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37533.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37535.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI44689.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BOLA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BOLA2 Gene

Proteomics data for BOLA2 Gene at MOPED

Post-translational modifications for BOLA2 Gene

  • Ubiquitination at Lys43 and Lys73
  • Modification sites at PhosphoSitePlus

Other Protein References for BOLA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BOLA2 Gene

Domains for BOLA2 Gene

Protein Domains for BOLA2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H3K6

UniProtKB/Swiss-Prot:

BOLA2_HUMAN :
  • Q9H3K6
Family:
  • Belongs to the BolA/IbaG family.
genes like me logo Genes that share domains with BOLA2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for BOLA2 Gene

Function for BOLA2 Gene

Animal Model Products

CRISPR Products

miRNA for BOLA2 Gene

miRTarBase miRNAs that target BOLA2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BOLA2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BOLA2 Gene

Localization for BOLA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BOLA2 Gene COMPARTMENTS Subcellular localization image for BOLA2 gene
Compartment Confidence
cytosol 2
extracellular 2
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BOLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome --
genes like me logo Genes that share ontologies with BOLA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BOLA2 Gene

Pathways for BOLA2 Gene

SuperPathways for BOLA2 Gene

No Data Available

Interacting Proteins for BOLA2 Gene

Gene Ontology (GO) - Biological Process for BOLA2 Gene

None

No data available for Pathways by source for BOLA2 Gene

Transcripts for BOLA2 Gene

mRNA/cDNA for BOLA2 Gene

(6) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BOLA2 Gene

BolA homolog 2 (E. coli):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BOLA2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BOLA2 Gene

No ASD Table

Relevant External Links for BOLA2 Gene

GeneLoc Exon Structure for
BOLA2
ECgene alternative splicing isoforms for
BOLA2

Expression for BOLA2 Gene

mRNA expression in normal human tissues for BOLA2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BOLA2 Gene

SOURCE GeneReport for Unigene cluster for BOLA2 Gene Hs.444600

genes like me logo Genes that share expressions with BOLA2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BOLA2 Gene

Orthologs for BOLA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BOLA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Bola2 16
Bola2 36
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100363408 35
  • 85.27 (n)
  • 81.4 (a)
zebrafish
(Danio rerio)
Actinopterygii BOLA2B 36
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG33672 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRA2 38
Species with no ortholog for BOLA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOLA2 Gene

ENSEMBL:
Gene Tree for BOLA2 (if available)
TreeFam:
Gene Tree for BOLA2 (if available)

Paralogs for BOLA2 Gene

Paralogs for BOLA2 Gene

Selected SIMAP similar genes for BOLA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BOLA2: view

Variants for BOLA2 Gene

Structural Variations from Database of Genomic Variants (DGV) for BOLA2 Gene

Variant ID Type Subtype PubMed ID
dgv845e1 CNV Complex 17122850
nsv905711 CNV Gain 21882294
esv29892 CNV Gain 19812545
esv2714183 CNV Deletion 23290073
nsv498862 CNV Loss 21111241
nsv820959 CNV Duplication 20802225
nsv9426 CNV Gain 18304495
nsv905720 CNV Loss 21882294
dgv846e1 CNV Complex 17122850
dgv847e1 CNV Complex 17122850
nsv905723 CNV Loss 21882294
nsv9431 CNV Gain+Loss 18304495
esv22245 CNV Gain 19812545
nsv821543 CNV Duplication 20802225
nsv471387 CNV Duplication 19718026
nsv471388 CNV Duplication 19718026

Relevant External Links for BOLA2 Gene

HapMap Linkage Disequilibrium report
BOLA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for BOLA2 Gene

Disorders for BOLA2 Gene

No disorders were found for BOLA2 Gene.

No data available for UniProtKB/Swiss-Prot for BOLA2 Gene

Publications for BOLA2 Gene

  1. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  2. Solution structure of a BolA-like protein from Mus musculus. (PMID: 14718656) Kasai T. … Yokoyama S. (Protein Sci. 2004) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PMID: 17620599) Xiao K. … Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3
  5. hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence. (PMID: 18548201) Zhou Y.B. … Han Z.G. (Mol. Cell. Biochem. 2008) 3

Products for BOLA2 Gene

Sources for BOLA2 Gene

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