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Aliases for BOLA2 Gene

Aliases for BOLA2 Gene

  • BolA Family Member 2 2 3 5
  • BOLA2A 3 4
  • BolA-Like Protein 2 Member A 3
  • BolA Homolog 2 (E. Coli) 2
  • BolA-Like 2 (E. Coli) 2
  • BolA Homolog 2 3
  • BOLA2 BOLA2B 4
  • BOLA2B 3
  • My016 3

External Ids for BOLA2 Gene

Previous GeneCards Identifiers for BOLA2 Gene

  • GC16U900508
  • GC16M029363
  • GC16M029364
  • GC16M029454
  • GC16M027866

Summaries for BOLA2 Gene

Entrez Gene Summary for BOLA2 Gene

  • This gene is located within a region of a segmental duplication on chromosome 16 and is identical to BOLA2B (bolA family member 2B). The product of this gene belongs to a family of proteins that are widely conserved and may be involved in iron maturation. Related pseudogenes are found multiple different chromosomes. Alternative splicing results in multiple transcript variants. Transcripts initiating at this locus may extend into downstream SMG1 pseudogene 6 (SMG1P6) and encode fusion proteins with a C-terminus related to SMG1 phosphatidylinositol 3-kinase-related kinase. A readthrough locus is represented with GeneID:107282092. [provided by RefSeq, Feb 2016]

GeneCards Summary for BOLA2 Gene

BOLA2 (BolA Family Member 2) is a Protein Coding gene. An important paralog of this gene is BOLA2B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOLA2 Gene

Genomics for BOLA2 Gene

Regulatory Elements for BOLA2 Gene

Enhancers for BOLA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BOLA2 on UCSC Golden Path with GeneCards custom track

Promoters for BOLA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BOLA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BOLA2 Gene

29,443,056 bp from pter
29,455,128 bp from pter
12,073 bases
Minus strand

Genomic View for BOLA2 Gene

Genes around BOLA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOLA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOLA2 Gene

Proteins for BOLA2 Gene

  • Protein details for BOLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BolA-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A1L454
    • A7YDY3

    Protein attributes for BOLA2 Gene

    86 amino acids
    Molecular mass:
    10117 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH22832.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI30402.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI30404.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37533.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37535.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI44689.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BOLA2 Gene


neXtProt entry for BOLA2 Gene

Proteomics data for BOLA2 Gene at MOPED

Post-translational modifications for BOLA2 Gene

  • Ubiquitination at Lys 43 and Lys 73
  • Modification sites at PhosphoSitePlus

Other Protein References for BOLA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BOLA2 Gene

Domains & Families for BOLA2 Gene

Protein Domains for BOLA2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BolA/IbaG family.
  • Belongs to the BolA/IbaG family.
genes like me logo Genes that share domains with BOLA2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for BOLA2 Gene

Function for BOLA2 Gene

Phenotypes for BOLA2 Gene

GenomeRNAi human phenotypes for BOLA2:
genes like me logo Genes that share phenotypes with BOLA2: view

Animal Model Products

miRNA for BOLA2 Gene

miRTarBase miRNAs that target BOLA2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOLA2 Gene

Localization for BOLA2 Gene

Subcellular locations from

Jensen Localization Image for BOLA2 Gene COMPARTMENTS Subcellular localization image for BOLA2 gene
Compartment Confidence
extracellular 5
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BOLA2 Gene

Pathways & Interactions for BOLA2 Gene

SuperPathways for BOLA2 Gene

No Data Available

Interacting Proteins for BOLA2 Gene

Gene Ontology (GO) - Biological Process for BOLA2 Gene


No data available for Pathways by source and SIGNOR curated interactions for BOLA2 Gene

Drugs & Compounds for BOLA2 Gene

No Compound Related Data Available

Transcripts for BOLA2 Gene

mRNA/cDNA for BOLA2 Gene

(7) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BOLA2 Gene

BolA homolog 2 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BOLA2 Gene

No ASD Table

Relevant External Links for BOLA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BOLA2 Gene

mRNA expression in normal human tissues for BOLA2 Gene

Protein differential expression in normal tissues from HIPED for BOLA2 Gene

This gene is overexpressed in Lavage (18.1) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BOLA2 Gene

SOURCE GeneReport for Unigene cluster for BOLA2 Gene Hs.444600

genes like me logo Genes that share expression patterns with BOLA2: view

Protein tissue co-expression partners for BOLA2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BOLA2 Gene

Orthologs for BOLA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BOLA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Rattus norvegicus)
Mammalia LOC100363408 35
  • 85.27 (n)
  • 81.4 (a)
(Bos Taurus)
Mammalia -- 36
  • 90 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
(Mus musculus)
Mammalia Bola2 36
  • 87 (a)
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
(Danio rerio)
Actinopterygii BOLA2B 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33672 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRA2 38
Species with no ortholog for BOLA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOLA2 Gene

Gene Tree for BOLA2 (if available)
Gene Tree for BOLA2 (if available)

Paralogs for BOLA2 Gene

Paralogs for BOLA2 Gene

(3) SIMAP similar genes for BOLA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BOLA2: view

Variants for BOLA2 Gene

Sequence variations from dbSNP and Humsavar for BOLA2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4352073 -- 29,444,552(-) TTCTC(C/G)ATGTC intron-variant
rs4479253 -- 29,446,686(-) CCAGC(A/G)CTTTG intron-variant
rs61565898 -- 29,450,788(+) TTTTT(-/TTTT)AAATG intron-variant, upstream-variant-2KB
rs62035616 -- 29,446,309(+) TGAGA(A/C)CCTGT intron-variant
rs28458446 -- 29,450,960(+) ATATA(A/T)TATAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BOLA2 Gene

Variant ID Type Subtype PubMed ID
dgv845e1 CNV Complex 17122850
nsv905711 CNV Gain 21882294
esv29892 CNV Gain 19812545
esv2714183 CNV Deletion 23290073
nsv498862 CNV Loss 21111241
nsv820959 CNV Duplication 20802225
nsv9426 CNV Gain 18304495
nsv905720 CNV Loss 21882294
dgv846e1 CNV Complex 17122850
dgv847e1 CNV Complex 17122850
nsv905723 CNV Loss 21882294
nsv9431 CNV Gain+Loss 18304495
esv22245 CNV Gain 19812545
nsv821543 CNV Duplication 20802225
nsv471387 CNV Duplication 19718026
nsv471388 CNV Duplication 19718026

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for BOLA2 Gene

Disorders for BOLA2 Gene

Relevant External Links for BOLA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BOLA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOLA2 Gene

Publications for BOLA2 Gene

  1. Solution structure of a BolA-like protein from Mus musculus. (PMID: 14718656) Kasai T. … Yokoyama S. (Protein Sci. 2004) 2 3 67
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  3. Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. (PMID: 26527279) Campos E.I. … Reinberg D. (Mol. Cell 2015) 3
  4. Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway. (PMID: 26613676) Banci L. … Muzzioli R. (J. Am. Chem. Soc. 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for BOLA2 Gene

Sources for BOLA2 Gene