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Aliases for BOLA2 Gene

Aliases for BOLA2 Gene

  • BolA Family Member 2 2 3 5
  • BOLA2A 3 4
  • BolA-Like Protein 2 Member A 3
  • BolA Homolog 2 (E. Coli) 2
  • BolA-Like 2 (E. Coli) 2
  • BolA-Like Protein 2 3
  • BolA Homolog 2 3
  • BOLA2 BOLA2B 4
  • BOLA2B 3
  • My016 3

External Ids for BOLA2 Gene

Previous GeneCards Identifiers for BOLA2 Gene

  • GC16U900508
  • GC16M029363
  • GC16M029364
  • GC16M029454
  • GC16M027866

Summaries for BOLA2 Gene

Entrez Gene Summary for BOLA2 Gene

  • This gene is located within a region of a segmental duplication on chromosome 16 and is identical to BOLA2B (bolA family member 2B). The product of this gene belongs to a family of proteins that are widely conserved and may be involved in iron maturation. Related pseudogenes are found multiple different chromosomes. Alternative splicing results in multiple transcript variants. Transcripts initiating at this locus may extend into downstream SMG1 pseudogene 6 (SMG1P6) and encode fusion proteins with a C-terminus related to SMG1 phosphatidylinositol 3-kinase-related kinase. A readthrough locus is represented with GeneID:107282092. [provided by RefSeq, Feb 2016]

GeneCards Summary for BOLA2 Gene

BOLA2 (BolA Family Member 2) is a Protein Coding gene. An important paralog of this gene is BOLA2B.

UniProtKB/Swiss-Prot for BOLA2 Gene

  • Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415).

Additional gene information for BOLA2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOLA2 Gene

Genomics for BOLA2 Gene

Regulatory Elements for BOLA2 Gene

Enhancers for BOLA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H029457 0.5 Ensembl dbSUPER 0.7 -2.5 -2473 0 BOLA2 SULT1A4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BOLA2 on UCSC Golden Path with GeneCards custom track

Promoters for BOLA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085048 528 2001

Genomic Location for BOLA2 Gene

Chromosome:
16
Start:
29,443,056 bp from pter
End:
29,455,128 bp from pter
Size:
12,073 bases
Orientation:
Minus strand

Genomic View for BOLA2 Gene

Genes around BOLA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOLA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOLA2 Gene

Proteins for BOLA2 Gene

  • Protein details for BOLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3K6-BOLA2_HUMAN
    Recommended name:
    BolA-like protein 2
    Protein Accession:
    Q9H3K6
    Secondary Accessions:
    • A1L454
    • A7YDY3

    Protein attributes for BOLA2 Gene

    Size:
    86 amino acids
    Molecular mass:
    10117 Da
    Quaternary structure:
    • Interacts with GLRX3; forms a heterotrimeric complex composed by two BOLA2 molecules and one GLRX3 molecule; linked by [2Fe-2S] clusters (PubMed:22309771, PubMed:26613676, PubMed:27519415).
    • Interacts with GLRX3; forms a heterotrimeric complex composed by two BOLA2 molecules and one GLRX3 molecule; linked by [2Fe-2S] clusters (PubMed:22309771, PubMed:26613676, PubMed:27519415).
    SequenceCaution:
    • Sequence=AAH22832.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI30402.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI30404.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37533.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI37535.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI44689.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BOLA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BOLA2 Gene

Post-translational modifications for BOLA2 Gene

  • Ubiquitination at posLast=4343 and posLast=7373
  • Modification sites at PhosphoSitePlus

Other Protein References for BOLA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BOLA2 Gene

Domains & Families for BOLA2 Gene

Gene Families for BOLA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BOLA2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H3K6

UniProtKB/Swiss-Prot:

BOLA2_HUMAN :
  • Belongs to the BolA/IbaG family.
Family:
  • Belongs to the BolA/IbaG family.
genes like me logo Genes that share domains with BOLA2: view

No data available for Suggested Antigen Peptide Sequences for BOLA2 Gene

Function for BOLA2 Gene

Molecular function for BOLA2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts together with the monothiol glutaredoxin GLRX3 (PubMed:26613676, PubMed:27519415).

Gene Ontology (GO) - Molecular Function for BOLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27519415
genes like me logo Genes that share ontologies with BOLA2: view

Phenotypes for BOLA2 Gene

genes like me logo Genes that share phenotypes with BOLA2: view

Animal Model Products

CRISPR Products

miRNA for BOLA2 Gene

miRTarBase miRNAs that target BOLA2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BOLA2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOLA2 Gene

Localization for BOLA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOLA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BOLA2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BOLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 22746225
GO:0005737 cytoplasm IDA,IEA 22746225
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with BOLA2: view

Pathways & Interactions for BOLA2 Gene

SuperPathways for BOLA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BOLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035722 interleukin-12-mediated signaling pathway TAS --
GO:0044571 [2Fe-2S] cluster assembly IDA 27519415
GO:0097428 protein maturation by iron-sulfur cluster transfer IDA 27519415
genes like me logo Genes that share ontologies with BOLA2: view

No data available for Pathways by source and SIGNOR curated interactions for BOLA2 Gene

Drugs & Compounds for BOLA2 Gene

No Compound Related Data Available

Transcripts for BOLA2 Gene

mRNA/cDNA for BOLA2 Gene

(3) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BOLA2 Gene

BolA homolog 2 (E. coli):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BOLA2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for BOLA2 Gene

No ASD Table

Relevant External Links for BOLA2 Gene

GeneLoc Exon Structure for
BOLA2
ECgene alternative splicing isoforms for
BOLA2

Expression for BOLA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BOLA2 Gene

Protein differential expression in normal tissues from HIPED for BOLA2 Gene

This gene is overexpressed in Lavage (18.1) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BOLA2 Gene



Protein tissue co-expression partners for BOLA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BOLA2 Gene:

BOLA2

SOURCE GeneReport for Unigene cluster for BOLA2 Gene:

Hs.444600

Evidence on tissue expression from TISSUES for BOLA2 Gene

  • Nervous system(4.9)
  • Eye(4.5)
  • Kidney(4.2)
  • Blood(4.1)
  • Skin(3.6)
  • Lung(3.1)
  • Pancreas(2.5)
genes like me logo Genes that share expression patterns with BOLA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BOLA2 Gene

Orthologs for BOLA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BOLA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Bola2 34
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100363408 33
  • 85.27 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BOLA2B 34
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG33672 34
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BOL2 36
Species where no ortholog for BOLA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOLA2 Gene

ENSEMBL:
Gene Tree for BOLA2 (if available)
TreeFam:
Gene Tree for BOLA2 (if available)

Paralogs for BOLA2 Gene

Paralogs for BOLA2 Gene

(3) SIMAP similar genes for BOLA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BOLA2: view

Variants for BOLA2 Gene

Sequence variations from dbSNP and Humsavar for BOLA2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1002602928 -- 29,455,497(+) GGTTC(C/T)GCCCC intron-variant, upstream-variant-2KB
rs145372287 -- 29,456,331(+) TAGTA(A/G)AGACG intron-variant, upstream-variant-2KB
rs202123825 -- 29,453,517(+) GACGG(A/T)GGCAG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs370863649 -- 29,456,955(+) ATTTA(-/T)TTTTT intron-variant, upstream-variant-2KB
rs62035617 -- 29,456,443(+) CCCGG(C/T)CCTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BOLA2 Gene

Variant ID Type Subtype PubMed ID
dgv1515e59 CNV duplication 20981092
esv22245 CNV gain 19812545
esv2714183 CNV deletion 23290073
esv2758641 CNV gain 17122850
esv2758642 CNV gain 17122850
esv29892 CNV gain 19812545
esv3333204 CNV duplication 20981092
esv3388213 CNV duplication 20981092
nsv1056249 CNV gain 25217958
nsv1078392 CNV duplication 25765185
nsv1078393 CNV duplication 25765185
nsv1139652 CNV duplication 24896259
nsv1141284 CNV duplication 24896259
nsv1146152 CNV duplication 26484159
nsv1150245 CNV duplication 26484159
nsv471387 CNV gain 19718026
nsv471388 CNV gain 19718026
nsv498862 CNV loss 21111241
nsv571809 CNV loss 21841781
nsv571810 CNV loss 21841781
nsv571819 CNV gain 21841781
nsv820959 CNV duplication 20802225
nsv821543 CNV duplication 20802225
nsv9426 CNV gain 18304495
nsv9431 CNV gain+loss 18304495
nsv960011 CNV duplication 23825009
nsv978130 CNV duplication 23825009

Relevant External Links for BOLA2 Gene

Human Gene Mutation Database (HGMD)
BOLA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BOLA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for BOLA2 Gene

Disorders for BOLA2 Gene

Relevant External Links for BOLA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BOLA2

No disorders were found for BOLA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOLA2 Gene

Publications for BOLA2 Gene

  1. A Glutaredoxin·BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery. (PMID: 27519415) Frey AG … Philpott CC (The Journal of biological chemistry 2016) 3 4 60
  2. Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway. (PMID: 26613676) Banci L … Muzzioli R (Journal of the American Chemical Society 2015) 3 4 60
  3. BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion. (PMID: 22746225) Willems P … Huynen MA (Antioxidants & redox signaling 2013) 3 4 60
  4. Human glutaredoxin 3 forms [2Fe-2S]-bridged complexes with human BolA2. (PMID: 22309771) Li H … Outten CE (Biochemistry 2012) 3 4 60
  5. Solution structure of a BolA-like protein from Mus musculus. (PMID: 14718656) Kasai T … Yokoyama S (Protein science : a publication of the Protein Society 2004) 2 3 60

Products for BOLA2 Gene

Sources for BOLA2 Gene

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