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Aliases for BOLA1 Gene

Aliases for BOLA1 Gene

  • BolA Family Member 1 2 3 5
  • BolA Homolog 1 (E. Coli) 2
  • BolA-Like 1 (E. Coli) 2
  • BolA-Like Protein 1 3
  • BolA Homolog 1 3
  • BolA-Like 1 3
  • CGI-143 3
  • HBolA 4

External Ids for BOLA1 Gene

Previous GeneCards Identifiers for BOLA1 Gene

  • GC01P146685
  • GC01P148126
  • GC01P149859
  • GC01P121251

Summaries for BOLA1 Gene

GeneCards Summary for BOLA1 Gene

BOLA1 (BolA Family Member 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BOLA1 Gene

  • Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225).

Additional gene information for BOLA1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOLA1 Gene

Genomics for BOLA1 Gene

Regulatory Elements for BOLA1 Gene

Enhancers for BOLA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H150008 1.8 FANTOM5 ENCODE dbSUPER 10.4 +122.3 122319 2 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC PRPF3 SETDB1 MTMR11 ARNT ADAMTSL4 SV2A UBE2D3P3 RPRD2 CTSK SF3B4
GH01H149846 1.3 Ensembl ENCODE dbSUPER 12 -39.2 -39198 3 TBP FOXA2 SIN3A ZSCAN5C SMAD5 SMARCA4 GLIS1 IKZF1 HMBOX1 HNF4A BOLA1 HIST2H2AC HIST2H2BE MTMR11 ENSG00000261716 HIST2H2AA3 LOC102723955 ENSG00000272993
GH01H150486 1.2 ENCODE 12.4 +599.8 599750 1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SETDB1 PIP5K1A PRPF3 SF3B4 ZNF687 GABPB2 PI4KB GOLPH3L ARNT UBE2D3P3
GH01H149843 1.1 ENCODE dbSUPER 12.9 -43.0 -43023 3 TBP INSM2 SIN3A ELK1 ZSCAN5C RCOR1 FOS SMAD5 CEBPB ZNF623 SV2A BOLA1 HIST2H2AC HIST2H2BE MTMR11 ENSG00000261716 HIST2H2AA3 ENSG00000272993 GC01P149843
GH01H149997 1.3 Ensembl ENCODE dbSUPER 10.4 +109.9 109911 0 HDAC1 HDGF TBL1XR1 BMI1 BATF ZNF766 ATF7 ETV6 RUNX3 CREM SV2A MTMR11 BOLA1 HIST2H2AB HIST2H2AC HIST2H2BE PLEKHO1 OTUD7B PIR49087
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BOLA1 on UCSC Golden Path with GeneCards custom track

Promoters for BOLA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013441 -690 4401 MLX ZFP64 FEZF1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610

Genomic Location for BOLA1 Gene

Chromosome:
1
Start:
149,887,890 bp from pter
End:
149,900,798 bp from pter
Size:
12,909 bases
Orientation:
Plus strand

Genomic View for BOLA1 Gene

Genes around BOLA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOLA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOLA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOLA1 Gene

Proteins for BOLA1 Gene

  • Protein details for BOLA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3E2-BOLA1_HUMAN
    Recommended name:
    BolA-like protein 1
    Protein Accession:
    Q9Y3E2
    Secondary Accessions:
    • B2R7K2
    • D3DUZ4
    • Q5QNY0

    Protein attributes for BOLA1 Gene

    Size:
    137 amino acids
    Molecular mass:
    14289 Da
    Quaternary structure:
    • Interacts with GLRX5 (PubMed:22746225, PubMed:27532773, PubMed:27532772).

    Three dimensional structures from OCA and Proteopedia for BOLA1 Gene

neXtProt entry for BOLA1 Gene

Post-translational modifications for BOLA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BOLA1 Gene

No data available for DME Specific Peptides for BOLA1 Gene

Domains & Families for BOLA1 Gene

Gene Families for BOLA1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for BOLA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BOLA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3E2

UniProtKB/Swiss-Prot:

BOLA1_HUMAN :
  • Belongs to the BolA/IbaG family.
Family:
  • Belongs to the BolA/IbaG family.
genes like me logo Genes that share domains with BOLA1: view

Function for BOLA1 Gene

Molecular function for BOLA1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772). May protect cells against oxidative stress (PubMed:22746225).

Phenotypes From GWAS Catalog for BOLA1 Gene

Gene Ontology (GO) - Molecular Function for BOLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BOLA1: view
genes like me logo Genes that share phenotypes with BOLA1: view

Animal Model Products

CRISPR Products

miRNA for BOLA1 Gene

miRTarBase miRNAs that target BOLA1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BOLA1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOLA1 Gene

Localization for BOLA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOLA1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BOLA1 gene
Compartment Confidence
mitochondrion 5
extracellular 3
nucleus 2
cytosol 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BOLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 22746225
genes like me logo Genes that share ontologies with BOLA1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BOLA1 Gene

Pathways & Interactions for BOLA1 Gene

SuperPathways for BOLA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BOLA1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BOLA1 Gene

Drugs & Compounds for BOLA1 Gene

No Compound Related Data Available

Transcripts for BOLA1 Gene

Unigene Clusters for BOLA1 Gene

BolA homolog 1 (E. coli):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BOLA1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for BOLA1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e
SP1: -
SP2: - -
SP3:

Relevant External Links for BOLA1 Gene

GeneLoc Exon Structure for
BOLA1
ECgene alternative splicing isoforms for
BOLA1

Expression for BOLA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BOLA1 Gene

Protein differential expression in normal tissues from HIPED for BOLA1 Gene

This gene is overexpressed in Uterus (10.7), Peripheral blood mononuclear cells (7.2), Adrenal (7.2), and Skin (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BOLA1 Gene



Protein tissue co-expression partners for BOLA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of BOLA1 Gene:

BOLA1

SOURCE GeneReport for Unigene cluster for BOLA1 Gene:

Hs.13880

mRNA Expression by UniProt/SwissProt for BOLA1 Gene:

Q9Y3E2-BOLA1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for BOLA1 Gene

  • Intestine(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with BOLA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BOLA1 Gene

Orthologs for BOLA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BOLA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BOLA1 33 34
  • 99.76 (n)
cow
(Bos Taurus)
Mammalia BOLA1 33 34
  • 84.46 (n)
dog
(Canis familiaris)
Mammalia BOLA1 33 34
  • 83.45 (n)
mouse
(Mus musculus)
Mammalia Bola1 33 16 34
  • 80.64 (n)
rat
(Rattus norvegicus)
Mammalia Bola1 33
  • 80.15 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia bola1 33
  • 57.43 (n)
zebrafish
(Danio rerio)
Actinopterygii bola1 33 34
  • 63.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31126 33 34
  • 49.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003706 33
  • 49.16 (n)
worm
(Caenorhabditis elegans)
Secernentea K11H12.1 33 34
  • 50.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 32 (a)
OneToOne
BOL1 36 36
Species where no ortholog for BOLA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BOLA1 Gene

ENSEMBL:
Gene Tree for BOLA1 (if available)
TreeFam:
Gene Tree for BOLA1 (if available)

Paralogs for BOLA1 Gene

No data available for Paralogs for BOLA1 Gene

Variants for BOLA1 Gene

Sequence variations from dbSNP and Humsavar for BOLA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000326062 -- 149,898,222(+) CATTA(A/G)AAGAG upstream-variant-2KB
rs1000376716 -- 149,898,543(+) GTACT(C/T)AAATA upstream-variant-2KB
rs1003949870 -- 149,899,357(+) AGGAG(G/T)TGGGC upstream-variant-2KB
rs1004298855 -- 149,899,096(+) CGGAA(A/G)TATTC upstream-variant-2KB
rs1008713826 -- 149,900,742(+) TTGCA(A/C)CAGAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BOLA1 Gene

Variant ID Type Subtype PubMed ID
nsv831525 CNV gain 17160897
nsv831537 CNV loss 17160897

Variation tolerance for BOLA1 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BOLA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BOLA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BOLA1 Gene

Disorders for BOLA1 Gene

Relevant External Links for BOLA1

Genetic Association Database (GAD)
BOLA1
Human Genome Epidemiology (HuGE) Navigator
BOLA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BOLA1

No disorders were found for BOLA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOLA1 Gene

Publications for BOLA1 Gene

  1. Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins. (PMID: 27532772) Uzarska MA … Lill R (eLife 2016) 3 4 60
  2. Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients. (PMID: 27532773) Melber A … Winge DR (eLife 2016) 3 4 60
  3. BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion. (PMID: 22746225) Willems P … Huynen MA (Antioxidants & redox signaling 2013) 3 4 60
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  5. hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence. (PMID: 18548201) Zhou YB … Han ZG (Molecular and cellular biochemistry 2008) 3 4 60

Products for BOLA1 Gene

Sources for BOLA1 Gene

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