BOLA1 Gene
protein-coding GIFtS: 46
GCID: GC01P149859
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bolA homolog 1 (E. coli)(Previous name: bolA-like 1 (E. coli) )
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Aliases
for BOLA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BolA Homolog 1 (E. Coli)1 2 | | CGI-1431 | | BolA-Like 1 (E. Coli)1 | | BolA-Like 12 | | BolA-Like Protein 12 | | HBolA1 |
Export aliases for BOLA1 gene to outside databasesPrevious GC identifers: GC01P146685 GC01P148126 GC01P121251 |
Summaries
for BOLA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for BOLA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BOLA1 gene promoter:
TBP GR-beta POU3F1 GCNF-1 GCNF ARP-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for BOLA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BOLA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21BOLA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P149859: view genomic region
(about GC identifiers)
Start:
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149,858,486 bp from pter |
End:
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149,872,351 bp from pter |
Size:
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13,866 bases |
Orientation:
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plus strand |
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Proteins
for BOLA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BOLA1_HUMAN, Q9Y3E2 (See
protein sequence)Recommended Name: BolA-like protein 1 Size: 137 amino acids; 14289 Da
Subcellular location: Secreted. Note=Could be secreted via a non-classical export pathway
Secondary accessions: B2R7K2 D3DUZ4 Q5QNY0Explore the universe of human proteins at neXtProt for BOLA1: NX_Q9Y3E2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3E2
BOLA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057158.1
ENSEMBL proteins: ENSP00000358149 ENSP00000358148 ENSP00000358146
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005739 | mitochondrion |
IEA | -- |
BOLA1 for ontologies About GeneDecksing
BOLA1 Antibody Products:
Assay Products for BOLA1: |
Protein
Domains /
Families
for BOLA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BOLA1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y3E2ProtoNet protein and cluster: Q9Y3E2 1 Blocks protein family: IPB002634 BolA-like protein
UniProtKB/Swiss-Prot: BOLA1_HUMAN, Q9Y3E2Similarity: Belongs to the bolA/yrbA family |
Function
for BOLA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BOLA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BOLA1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for BOLA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BOLA1 |
|
Pathways & Interactions
for BOLA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BOLA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/13 Interacting proteins for BOLA1 (Q9Y3E23 ENSP000003581464) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
|
Drugs & Compounds
for BOLA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BOLA1
Search CenterWatch for drugs/clinical trials and news about BOLA1
|
Transcripts
for BOLA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BOLA1 gene: NM_016074.3 Unigene Cluster for BOLA1: BolA homolog 1 (E. coli) Hs.13880 [show with all ESTs]Unigene Representative Sequence: BF9704304 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369153 ENST00000369152(uc001etf.3) ENST00000476344 ENST00000369150
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BOLA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BOLA1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BOLA1 (NM_016074) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BOLA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BOLA1 |
Additional cDNA sequence: AF151901.1 AK313014.1 BC002771.2 BC063405.1 7 DOTS entries: DT.446005 DT.100769665 DT.121432849 DT.100736503 DT.40108385 DT.115168 DT.99947181 24/86 AceView cDNA sequences (see all 86): CF127829 BC060324 CA426321 BM792648 AA760787 CK902603 CF529778 AA593682 CF529345 BC063405 CA389141 BU753853 NM_003517 BX282022 H50355 AA810028 AA483644 BI822618 BE384900 BQ012459 AJ713269 W56364 BF970430 AA770693
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for BOLA1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e |
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| SP1: | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BOLA1
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Expression
for BOLA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BOLA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAAATCGTG
About this image
See BOLA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BOLA1
SOURCE GeneReport for Unigene cluster: Hs.13880
UniProtKB/Swiss-Prot: BOLA1_HUMAN, Q9Y3E2Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for BOLA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BOLA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BOLA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BOLA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BOLA1 |
Orthologs
for BOLA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the last universal common ancestor (LUCA).
Orthologs for BOLA1 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for BOLA1 (if available)
TreeFam Gene Tree for BOLA1 (if available) |
Paralogs
for BOLA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for BOLA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BOLA1 (149858486 - 149872351 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for BOLA1
3 CNVs: 3313 2326 8329 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BOLA1 |
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Disorders
/ Diseases
for BOLA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BOLA1 for disorders About GeneDecksing
OMIM gene information: 613181
OMIM disorders: --
2  diseases for BOLA1: About MalaCardschoroiditis malaria
Human Genome Epidemiology (HuGE) Navigator: BOLA1 (1 document)
Export disorders for BOLA1 gene to outside databases
|
Publications
for BOLA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BOLA1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with BOLA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence. (PubMed id 18548201)1, 2 Zhou Y.B.... Han Z.G. (2008)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Solution structure of a BolA-like protein from Mus musculus. (PubMed id 14718656)1, 3 Kasai T....Yokoyama S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
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External Searches for BOLA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing BOLA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BOLA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BOLA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BOLA1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for BOLA1 gene:
Search GeneIP for patents involving BOLA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BOLA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BOLA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BOLA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BOLA1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BOLA1 | | OriGene 3'-UTR Clone for BOLA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BOLA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BOLA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for BOLA1 |
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 | | | BOLA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for BOLA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BOLA1 |
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