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BOK Gene

protein-coding   GIFtS: 56
GCID: GC02P242498

BCL2-Related Ovarian Killer

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BCL2-Related Ovarian Killer1 2     BOKL2
Bcl-2-Like Protein 92 3     Bcl-2-Related Ovarian Killer Protein2
BCL2L92 3     bcl2-L-92
hBOK2 3     Bcl2-L-93

External Ids:    HGNC: 10871   Entrez Gene: 6662   Ensembl: ENSG000001767207   OMIM: 6054045   UniProtKB: Q9UMX33   

Export aliases for BOK gene to outside databases

Previous GC identifers: GC02U990010 GC02M239779 GC02P242517 GC02P242818 GC02P242218 GC02P242146 GC02P234252


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BOK Gene:
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act
as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat
show that this protein has restricted expression in reproductive tissues, interacts strongly with some
antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected
cells. Thus, this protein represents a proapoptotic member of the BCL2 family. (provided by RefSeq, Sep 2011)

GeneCards Summary for BOK Gene:
BOK (BCL2-related ovarian killer) is a protein-coding gene. Diseases associated with BOK include werdnig-hoffmann disease, and granular cell tumor. GO annotations related to this gene include protein heterodimerization activity and BH domain binding.

UniProtKB/Swiss-Prot: BOK_HUMAN, Q9UMX3
Function: May play a role in apoptosis

Gene Wiki entry for BOK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BOK gene promoter:
         AhR   c-Fos   AP-1   ATF-2   Arnt   PPAR-alpha   N-Myc   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBOK promoter sequence
   Search Chromatin IP Primers for BOK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BOK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

BOK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BOK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P242498:  view genomic region     (about GC identifiers)

Start:
242,498,136 bp from pter      End:
242,513,553 bp from pter
Size:
15,418 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BOK_HUMAN, Q9UMX3 (See protein sequence)
Recommended Name: Bcl-2-related ovarian killer protein  
Size: 212 amino acids; 23280 Da

Explore the universe of human proteins at neXtProt for BOK: NX_Q9UMX3

Explore proteomics data for BOK at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BOK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115904.1  
    ENSEMBL proteins: 
     ENSP00000314132  

    BOK Human Recombinant Protein Products:

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    BOK Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR026309 BOK
     IPR002475 Bcl2-like
     IPR026298 Blc2_fam

    Graphical View of Domain Structure for InterPro Entry Q9UMX3

    ProtoNet protein and cluster: Q9UMX3

    2 Blocks protein domains:
    IPB000712 Apoptosis regulator Bcl-2 protein
    IPB003093 Apoptosis regulator Bcl-2 protein


    UniProtKB/Swiss-Prot: BOK_HUMAN, Q9UMX3
    Similarity: Belongs to the Bcl-2 family


    BOK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BOK_HUMAN, Q9UMX3
    Function: May play a role in apoptosis

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15868100
    GO:0042803protein homodimerization activity IBA--
    GO:0046982protein heterodimerization activity IBA--
    GO:0046983protein dimerization activity ----
    GO:0051400BH domain binding IEA--
         
    BOK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BOK:
     Increased G2M DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bok):
     hematopoietic system  immune system  tumorigenesis 

    BOK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Boktm1.1Ast for BOK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BOK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BOK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BOK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BOK

    miRNA
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    miRTarBase miRNAs that target BOK:
    hsa-mir-331-3p (MIRT043544)

    Block miRNA regulation of human, mouse, rat BOK using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate BOK:
    hsa-miR-661 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidBOK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BOK
    Predesigned siRNA for gene silencing in human, mouse, rat BOK

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for BOK

    Clone
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    GenScript: all cDNA clones in your preferred vector: BOK (NM_032515)
    Sino Biological Human cDNA Clone for BOK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BOK
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BOK

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    extracellular2
    cytosol1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19095301
    GO:0005737cytoplasm IDA15868100
    GO:0005739mitochondrion IDA19095301
    GO:0005741mitochondrial outer membrane IBA--
    GO:0031966mitochondrial membrane IDA15868100

    BOK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BOK About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis (WikiPathways)
    Apoptosis0.38
    Apoptosis Modulation and Signaling0.38
    2TP53 network
    TP53 network


    3 BioSystems Pathways for BOK
        Apoptosis
    Apoptosis Modulation and Signaling
    TP53 network



        Pathway & Disease-focused RT2 Profiler PCR Arrays including BOK: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for BOK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for BOK (Q9UMX32, 3 ENSP000003141324) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOA1Q8NC602, 3, ENSP000002642304MINT-8249652 I2D: score=2 STRING: ENSP00000264230
    MCL1Q078203, ENSP000003580224I2D: score=3 STRING: ENSP00000358022
    BCL2A1Q165483, ENSP000002679534I2D: score=2 STRING: ENSP00000267953
    APAF1ENSP000003530594STRING: ENSP00000353059
    BCL2L10ENSP000002604424STRING: ENSP00000260442
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IDA15102863
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IMP--
    GO:0007420brain development IEA--
    GO:0008283cell proliferation IEP19095301
    GO:0008584male gonad development IEA--

    BOK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BOK

    7 Novoseek inferred chemical compound relationships for BOK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 11.4 2 12209691 (1), 10940486 (1)
    estradiol 8.64 1 10940486 (1)
    thymidine 8.53 1 18054556 (1)
    oxygen 0 1 9274913 (1)
    estrogen 0 1 12209691 (1)
    retinoic acid 0 1 14592536 (1)
    vegf 0 1 11329148 (1)



    BOK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BOK gene: 
    NM_032515.4  

    Unigene Cluster for BOK:

    BCL2-related ovarian killer
    Hs.293753  [show with all ESTs]
    Unigene Representative Sequence: NM_032515
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000318407(uc002wbq.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat BOK using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate BOK:
    hsa-miR-661 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidBOK 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BOK
    Predesigned siRNA for gene silencing in human, mouse, rat BOK
    Clone
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    OriGene clones in human, mouse for BOK (see all 6)
    OriGene ORF clones in mouse, rat for BOK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BOK (NM_032515)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BOK
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BOK
    Primer
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    OriGene qPCR primer pairs and template standards for BOK
    OriGene qSTAR qPCR primer pairs in human, mouse for BOK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BOK
      QuantiTect SYBR Green Assays in human, mouse, rat BOK
      QuantiFast Probe-based Assays in human, mouse, rat BOK

    Additional mRNA sequence: 

    AF174487.1 BT007272.1 

    6 DOTS entries:

    DT.97843721  DT.445800  DT.75191678  DT.100728025  DT.100736833  DT.100718955 

    Selected AceView cDNA sequences (see all 181):

    BX460019 BQ225038 BI820437 BM761650 AI754755 AK125061 BQ648903 BM986756 
    BU729827 AI369428 AI972382 NM_032515 AI122870 AW169875 AW511718 AI950730 
    AI250619 BI793225 BQ937494 AI929578 AA478794 W51860 BM762787 AI436288 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BOK    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                          -           -                                             
    SP2:                          -           -     -                                       
    SP3:                                                                                    
    SP4:                          -     -     -     -                                       
    SP5:                                -     -     -                                       


    ECgene alternative splicing isoforms for BOK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BOK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCAGGACA
    BOK Expression
    About this image

    BOK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BOK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.293753

    UniProtKB/Swiss-Prot: BOK_HUMAN, Q9UMX3
    Tissue specificity: Expressed in brain, liver, appendix and lymphoid tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BOK: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BOK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BOK gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bok1 , 5 BCL2-related ovarian killer protein1, 5 88.68(n)1
    95.75(a)1
      1 (47.28 cM)5
    518001  NM_016778.21  NP_058058.11 
     936856945 
    chicken
    (Gallus gallus)
    Aves BOK1 BCL2-related ovarian killer 78.62(n)
    81.6(a)
      395445  NM_204706.1  NP_990037.1 
    lizard
    (Anolis carolinensis)
    Reptilia BOK6
    BCL2-related ovarian killer
    76(a)
    1 ↔ 1
    3(30473391-30501947)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ069471.12   -- 71.27(n)    BJ069471.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640412 similar to BCL2-related ovarian killer 75.55(n)   394160  BC053218.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Buffy1 Buffy 48.77(n)
    35.19(a)
      36251  NM_078978.1  NP_523702.1 


    ENSEMBL Gene Tree for BOK (if available)
    TreeFam Gene Tree for BOK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BOK (see all 435)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58397681,2
    C--242500558(-) TAAAG-/AGCTGC 1 -- int10--------
    rs15534701,2
    C--242500561(-) TGATAA/CAGGCT 1 -- int10--------
    rs1865621771,2
    --242500580(+) GGTCCA/GGTCAG 1 -- int10--------
    rs8765311,2
    C,F,A,H--242500662(+) ATTCTT/CGGCAC 1 -- int116Minor allele frequency- C:0.45NS EA WA CSA NA 2214
    rs1931150601,2
    --242500726(+) GGGGCA/GGTGGG 1 -- int10--------
    rs1120800081,2
    C--242500884(+) CAGTGA/C/TGGGTG 1 -- int11NA 2
    rs1136268321,2
    C--242500952(+) GACAGC/G/TGGCCC 1 -- int11NA 2
    rs1856286801,2
    --242501202(+) CCCAGG/TACAGC 1 -- int10--------
    rs1150520121,2
    F--242501358(+) CTGCCC/TAGCCC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs731235241,2
    C,F--242501374(+) CACGTC/TGGGGT 1 -- int13Minor allele frequency- T:0.12WA CSA 122

    HapMap Linkage Disequilibrium report for BOK (242498136 - 242513553 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BOK (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722008CNV Deletion23290073
    esv2722010CNV Deletion23290073
    esv2233361CNV Deletion18987734
    esv2722009CNV Deletion23290073
    esv2668476CNV Deletion23128226
    esv2634239CNV Deletion19546169
    dgv4493n71CNV Loss21882294
    nsv876229CNV Loss21882294
    esv9037CNV Loss19470904
    esv27771CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BOK
    DNA2.0 Custom Variant and Variant Library Synthesis for BOK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605404    OMIM disorders: --

    Selected diseases for BOK (see all 40):    
    About MalaCards
    werdnig-hoffmann disease    granular cell tumor    parathyroid adenoma    polycythemia vera
    endometrial adenocarcinoma    polycythemia    myelodysplastic syndromes    myasthenia gravis
    vasculitis    eclampsia    pre-eclampsia    colon adenocarcinoma
    ovarian cancer    colorectal cancer    endometrial carcinoma    osteoarthritis
    myopathy    acute myeloid leukemia    adenocarcinoma    adenoma


    BOK for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for BOK gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 24.6 8 15905199 (1), 16528364 (1), 12197230 (1), 16615003 (1) (see all 7)
    aggressiveness 17.9 1 12680148 (1)
    myelodysplastic syndromes 14.1 1 9886323 (1)
    glioma 12.5 1 10873619 (1)
    ovarian cancer 10.9 1 9615792 (1)
    colorectal cancer 10.5 1 19453036 (1)
    carcinoma 8.39 1 12680148 (1)
    adenocarcinoma 6.21 1 9180925 (1)
    necrosis 0 2 16528364 (1), 10385052 (1)
    breast cancer 0 2 14592536 (1), 9252670 (1)

    Genetic Association Database (GAD): BOK

    Export disorders for BOK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BOK gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with BOK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolutionarily conserved Bok proteins in the Bcl-2 family. (PubMed id 11034351)1, 2, 3 Zhang H.... De Geyter C. (FEBS Lett. 2000)
    2. Voxelwise genome-wide association study (vGWAS). (PubMed id 20171287)1, 4 Stein J.L....Thompson P. (Neuroimage 2010)
    3. BOK and NOXA are essential mediators of p53-dependent apoptosis. (PubMed id 15102863)1, 3 Yakovlev A.G....Faden A.I. (J. Biol. Chem. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL. (PubMed id 9535847)1, 2 Inohara N.... Nunez G. (J. Biol. Chem. 1998)
    6. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. (PubMed id 9356461)1, 3 Hsu S.Y....Hsueh A.J. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    7. A natural antisense transcript, BOKAS, regulates the pro-apoptotic activity of human Bok. (PubMed id 19287972)1, 9 Zhang H....De Geyter C. (Int. J. Oncol. 2009)
    8. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    9. The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage. (PubMed id 23884412)1 Schulman J.J....Wojcikiewicz R.J. (J. Biol. Chem. 2013)
    10. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 666 HGNC: 1087 AceView: BOK Ensembl:ENSG00000176720 euGenes: HUgn666
    ECgene: BOK H-InvDB: BOK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BOK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BOK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BOK gene:
    Search GeneIP for patents involving BOK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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