Aliases for BOK Gene
External Ids for BOK Gene
Previous GeneCards Identifiers for BOK Gene
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]
GeneCards Summary for BOK Gene
BOK (BCL2-Related Ovarian Killer) is a Protein Coding gene. Diseases associated with BOK include colorectal cancer. Among its related pathways are Apoptosis (WikiPathways) and Apoptosis (WikiPathways). GO annotations related to this gene include protein heterodimerization activity and BH domain binding.
UniProtKB/Swiss-Prot for BOK Gene
Induces apoptosis in a manner dependent on BAX and BAK.