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Aliases for BOK Gene

Aliases for BOK Gene

  • BCL2-Related Ovarian Killer 2 3
  • Bcl-2-Like Protein 9 3 4
  • Bcl2-L-9 3 4
  • BCL2L9 3 4
  • HBOK 3 4
  • Bcl-2-Related Ovarian Killer Protein 3
  • BOKL 3

External Ids for BOK Gene

Previous GeneCards Identifiers for BOK Gene

  • GC02U990010
  • GC02M239779
  • GC02P242517
  • GC02P242818
  • GC02P242218
  • GC02P242146
  • GC02P234252
  • GC02P242498

Summaries for BOK Gene

Entrez Gene Summary for BOK Gene

  • The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]

GeneCards Summary for BOK Gene

BOK (BCL2-Related Ovarian Killer) is a Protein Coding gene. Diseases associated with BOK include colorectal cancer. Among its related pathways are Apoptosis (WikiPathways) and Apoptosis (WikiPathways). GO annotations related to this gene include protein heterodimerization activity and BH domain binding.

UniProtKB/Swiss-Prot for BOK Gene

  • Induces apoptosis in a manner dependent on BAX and BAK.

Gene Wiki entry for BOK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOK Gene

Genomics for BOK Gene

Regulatory Elements for BOK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BOK Gene

241,558,721 bp from pter
241,574,138 bp from pter
15,418 bases
Plus strand

Genomic View for BOK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BOK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOK Gene

Proteins for BOK Gene

  • Protein details for BOK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bcl-2-related ovarian killer protein
    Protein Accession:
    Secondary Accessions:

    Protein attributes for BOK Gene

    212 amino acids
    Molecular mass:
    23280 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BOK Gene

Proteomics data for BOK Gene at MOPED

Post-translational modifications for BOK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BOK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BOK Gene

Domains for BOK Gene

Gene Families for BOK Gene

Suggested Antigen Peptide Sequences for BOK Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Bcl-2 family.
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with BOK: view

Function for BOK Gene

Molecular function for BOK Gene

UniProtKB/Swiss-Prot Function:
Induces apoptosis in a manner dependent on BAX and BAK.

Gene Ontology (GO) - Molecular Function for BOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15868100
GO:0042803 protein homodimerization activity IBA --
GO:0046982 protein heterodimerization activity IBA --
GO:0046983 protein dimerization activity --
GO:0051400 BH domain binding IEA --
genes like me logo Genes that share ontologies with BOK: view

Phenotypes for BOK Gene

genes like me logo Genes that share phenotypes with BOK: view

Animal Models for BOK Gene

MGI Knock Outs for BOK:

Animal Model Products

miRNA for BOK Gene

miRTarBase miRNAs that target BOK

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BOK

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BOK Gene

Localization for BOK Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOK Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Note=The transmembrane domain is necessary and sufficient for Golgi and ER targeting. {ECO:0000269 PubMed:23429263}.

Subcellular locations from

Jensen Localization Image for BOK Gene COMPARTMENTS Subcellular localization image for BOK gene
Compartment Confidence
mitochondrion 5
nucleus 5
extracellular 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IDA 19095301
GO:0005737 cytoplasm IDA 15868100
GO:0005739 mitochondrion IDA 19095301
GO:0005741 mitochondrial outer membrane IBA --
genes like me logo Genes that share ontologies with BOK: view

Pathways for BOK Gene

genes like me logo Genes that share pathways with BOK: view

Pathways by source for BOK Gene

3 BioSystems pathways for BOK Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BOK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 15102863
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP 20673843
GO:0007420 brain development IEA --
GO:0008283 cell proliferation IEP 19095301
GO:0008584 male gonad development IEA --
genes like me logo Genes that share ontologies with BOK: view

Compounds for BOK Gene

(4) ApexBio Compounds for BOK Gene

Compound Action Cas Number
AT-101 "BH3-mimetic,gossypol enantiomer" [90141-22-3]
Bax inhibitor peptide P5 Bax inhibitor [579492-83-4]
Bax inhibitor peptide V5 Bax inhibitor [579492-81-2]
Gossypol PAF inhibitor;anti-fertility and anti-cancer [303-45-7]

(7) Novoseek inferred chemical compound relationships for BOK Gene

Compound -log(P) Hits PubMed IDs
progesterone 11.4 2
estradiol 8.64 1
thymidine 8.53 1
oxygen 0 1
estrogen 0 1
genes like me logo Genes that share compounds with BOK: view

Transcripts for BOK Gene

mRNA/cDNA for BOK Gene

Unigene Clusters for BOK Gene

BCL2-related ovarian killer:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BOK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BOK Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: - - -
SP4: - - - -
SP5: - - -

Relevant External Links for BOK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BOK Gene

mRNA expression in normal human tissues for BOK Gene

mRNA differential expression in normal tissues according to GTEx for BOK Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.7) and Liver (4.2).

Protein differential expression in normal tissues for BOK Gene

This gene is overexpressed in Liver (11.6), Urinary Bladder (10.0), Rectum (9.5), Prostate (9.2), and Fetal gut (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BOK Gene

SOURCE GeneReport for Unigene cluster for BOK Gene Hs.293753

mRNA Expression by UniProt/SwissProt for BOK Gene

Tissue specificity: Expressed in brain, liver, appendix and lymphoid tissues.
genes like me logo Genes that share expressions with BOK: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for BOK Gene

Orthologs for BOK Gene

This gene was present in the common ancestor of animals.

Orthologs for BOK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BOK 35
  • 89.78 (n)
  • 94.81 (a)
BOK 36
  • 94 (a)
(Canis familiaris)
Mammalia BOK 35
  • 91.67 (n)
  • 90.79 (a)
BOK 36
  • 88 (a)
(Mus musculus)
Mammalia Bok 35
  • 88.68 (n)
  • 95.75 (a)
Bok 16
Bok 36
  • 95 (a)
(Pan troglodytes)
Mammalia BOK 35
  • 97.79 (n)
  • 98.1 (a)
BOK 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Bok 35
  • 88.21 (n)
  • 95.75 (a)
(Monodelphis domestica)
Mammalia BOK 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia BOK 36
  • 79 (a)
(Gallus gallus)
Aves BOK 35
  • 78.62 (n)
  • 81.6 (a)
BOK 36
  • 81 (a)
(Anolis carolinensis)
Reptilia BOK 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bok 35
  • 64.62 (n)
  • 70.28 (a)
(Danio rerio)
Actinopterygii boka 35
  • 68.57 (n)
  • 68.1 (a)
zgc64041 35
boka 36
  • 64 (a)
bokb 36
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta Buffy 35
  • 48.77 (n)
  • 35.19 (a)
Buffy 36
  • 21 (a)
debcl 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2249 36
  • 20 (a)
Species with no ortholog for BOK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOK Gene

Gene Tree for BOK (if available)
Gene Tree for BOK (if available)

Paralogs for BOK Gene

No data available for Paralogs for BOK Gene

Variants for BOK Gene

Sequence variations from dbSNP and Humsavar for BOK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs876531 -- 241,561,247(+) ATTCT(C/T)GGCAC intron-variant
rs1128528 -- 241,573,555(+) TGACA(C/T)CCACT utr-variant-3-prime
rs1553470 -- 241,561,146(-) TGATA(A/C)AGGCT intron-variant
rs3210568 -- 241,573,321(+) CTCCT(C/G)TCACC utr-variant-3-prime
rs4675799 -- 241,567,522(-) GGCAC(A/G)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BOK Gene

Variant ID Type Subtype PubMed ID
nsv876226 CNV Loss 21882294
dgv1296e1 CNV Complex 17122850
nsv834588 CNV Loss 17160897
dgv4493n71 CNV Loss 21882294
nsv876228 CNV Loss 21882294
nsv876229 CNV Loss 21882294
dgv4494n71 CNV Loss 21882294
dgv4495n71 CNV Loss 21882294
esv2722008 CNV Deletion 23290073
esv2668476 CNV Deletion 23128226
esv2634239 CNV Deletion 19546169
esv2233361 CNV Deletion 18987734
esv2722009 CNV Deletion 23290073
esv9037 CNV Loss 19470904
esv27771 CNV Loss 19812545
esv27015 CNV Gain 19812545
esv2722010 CNV Deletion 23290073

Relevant External Links for BOK Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BOK Gene

Disorders for BOK Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BOK Gene in MalaCards »

(1) Disease for BOK Gene

(11) Novoseek inferred disease relationships for BOK Gene

Disease -log(P) Hits PubMed IDs
tumors 24.6 7
aggressiveness 17.9 1
myelodysplastic syndromes 14.1 1
glioma 12.5 1
ovarian cancer 10.9 1

Relevant External Links for BOK

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with BOK: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for BOK Gene

Publications for BOK Gene

  1. Evolutionarily conserved Bok proteins in the Bcl-2 family. (PMID: 11034351) Zhang H. … De Geyter C. (FEBS Lett. 2000) 2 3 4
  2. BOK and NOXA are essential mediators of p53-dependent apoptosis. (PMID: 15102863) Yakovlev A.G. … Faden A.I. (J. Biol. Chem. 2004) 2 3
  3. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. (PMID: 9356461) Hsu S.Y. … Hsueh A.J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3
  4. Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL. (PMID: 9535847) Inohara N. … Nunez G. (J. Biol. Chem. 1998) 3 4
  5. A natural antisense transcript, BOKAS, regulates the pro-apoptotic activity of human Bok. (PMID: 19287972) Zhang H. … De Geyter C. (Int. J. Oncol. 2009) 3 23

Products for BOK Gene

Sources for BOK Gene

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