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Aliases for BOD1L2 Gene

Aliases for BOD1L2 Gene

  • Biorientation Of Chromosomes In Cell Division 1 Like 2 2 3
  • Biorientation Of Chromosomes In Cell Division Protein 1 Pseudogene 3 4
  • Biorientation Of Chromosomes In Cell Division 1 Pseudogene 2 3
  • Biorientation Of Chromosomes In Cell Division 1-Like 2 3 5
  • Family With Sequence Similarity 44, Member C 2 3
  • FAM44C 3 4
  • BOD1P 3 4
  • Putative Biorientation Of Chromosomes In Cell Division Protein 1 Pseudogene 3
  • Putative Biorientation Of Chromosomes In Cell Division Protein 1-Like 2 3
  • Putative Protein FAM44C 3
  • Protein FAM44C 4

External Ids for BOD1L2 Gene

Previous HGNC Symbols for BOD1L2 Gene

  • FAM44C
  • BOD1P

Previous GeneCards Identifiers for BOD1L2 Gene

  • GC18P054826
  • GC18P054831
  • GC18P054835
  • GC18P054840

Summaries for BOD1L2 Gene

GeneCards Summary for BOD1L2 Gene

BOD1L2 (Biorientation Of Chromosomes In Cell Division 1 Like 2) is a Protein Coding gene. An important paralog of this gene is BOD1L1.

UniProtKB/Swiss-Prot for BOD1L2 Gene

  • May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOD1L2 Gene

Genomics for BOD1L2 Gene

Genomic Location for BOD1L2 Gene

Chromosome:
18
Start:
57,147,062 bp from pter
End:
57,150,408 bp from pter
Size:
3,347 bases
Orientation:
Plus strand

Genomic View for BOD1L2 Gene

Genes around BOD1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOD1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOD1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOD1L2 Gene

No data available for Regulatory Elements for BOD1L2 Gene

Proteins for BOD1L2 Gene

  • Protein details for BOD1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYS8-BD1L2_HUMAN
    Recommended name:
    Biorientation of chromosomes in cell division protein 1-like 2
    Protein Accession:
    Q8IYS8
    Secondary Accessions:
    • B3KXU4
    • Q8WW13

    Protein attributes for BOD1L2 Gene

    Size:
    172 amino acids
    Molecular mass:
    18075 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BOD1L2 Gene

Proteomics data for BOD1L2 Gene at MOPED

Post-translational modifications for BOD1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BOD1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BOD1L2 Gene

Domains & Families for BOD1L2 Gene

Protein Domains for BOD1L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BOD1L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYS8

UniProtKB/Swiss-Prot:

BD1L2_HUMAN :
  • Belongs to the BOD1 family.
Family:
  • Belongs to the BOD1 family.
genes like me logo Genes that share domains with BOD1L2: view

No data available for Gene Families for BOD1L2 Gene

Function for BOD1L2 Gene

Molecular function for BOD1L2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BOD1L2 Gene

Localization for BOD1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOD1L2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BOD1L2 Gene COMPARTMENTS Subcellular localization image for BOD1L2 gene
Compartment Confidence
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for BOD1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IEA --
genes like me logo Genes that share ontologies with BOD1L2: view

Pathways & Interactions for BOD1L2 Gene

SuperPathways for BOD1L2 Gene

No Data Available

Interacting Proteins for BOD1L2 Gene

Gene Ontology (GO) - Biological Process for BOD1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with BOD1L2: view

No data available for Pathways by source and SIGNOR curated interactions for BOD1L2 Gene

Drugs & Compounds for BOD1L2 Gene

No Compound Related Data Available

Transcripts for BOD1L2 Gene

mRNA/cDNA for BOD1L2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BOD1L2 Gene

Biorientation of chromosomes in cell division 1-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BOD1L2 Gene

No ASD Table

Relevant External Links for BOD1L2 Gene

GeneLoc Exon Structure for
BOD1L2
ECgene alternative splicing isoforms for
BOD1L2

Expression for BOD1L2 Gene

mRNA expression in normal human tissues for BOD1L2 Gene

mRNA differential expression in normal tissues according to GTEx for BOD1L2 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for BOD1L2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BOD1L2 Gene



SOURCE GeneReport for Unigene cluster for BOD1L2 Gene Hs.127882

genes like me logo Genes that share expression patterns with BOD1L2: view

Protein tissue co-expression partners for BOD1L2 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BOD1L2 Gene

Orthologs for BOD1L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BOD1L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BOD1L2 35
  • 99.79 (n)
  • 100 (a)
BOD1L2 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BOD1 36
  • 71 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BOD1 36
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Bod1 36
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii bod1 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5514 36
  • 5 (a)
OneToMany
Species with no ortholog for BOD1L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOD1L2 Gene

ENSEMBL:
Gene Tree for BOD1L2 (if available)
TreeFam:
Gene Tree for BOD1L2 (if available)

Paralogs for BOD1L2 Gene

Paralogs for BOD1L2 Gene

(2) SIMAP similar genes for BOD1L2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for BOD1L2 Gene

genes like me logo Genes that share paralogs with BOD1L2: view

Variants for BOD1L2 Gene

Sequence variations from dbSNP and Humsavar for BOD1L2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs16743 -- 57,148,476(-) CAGAG(-/AG)TCTGC utr-variant-3-prime
rs7231751 -- 57,146,128(+) TACAT(C/T)TCAGG upstream-variant-2KB
rs8085797 -- 57,149,352(+) AAAGA(A/G)ACCAG utr-variant-3-prime
rs7232905 -- 57,146,807(+) CACCC(A/C)GTTGT upstream-variant-2KB
rs8086063 -- 57,149,529(+) AAATG(A/G)TTCTT utr-variant-3-prime

Variation tolerance for BOD1L2 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for BOD1L2 Gene

Disorders for BOD1L2 Gene

Relevant External Links for BOD1L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BOD1L2

No disorders were found for BOD1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOD1L2 Gene

Publications for BOD1L2 Gene

  1. Bod1, a novel kinetochore protein required for chromosome biorientation. (PMID: 17938248) Porter I.M. … Swedlow J.R. (J. Cell Biol. 2007) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for BOD1L2 Gene

Sources for BOD1L2 Gene

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