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Aliases for BOD1L2 Gene

Aliases for BOD1L2 Gene

  • Biorientation Of Chromosomes In Cell Division 1 Like 2 2 3 5
  • Biorientation Of Chromosomes In Cell Division Protein 1 Pseudogene 3 4
  • Biorientation Of Chromosomes In Cell Division 1 Pseudogene 2 3
  • Family With Sequence Similarity 44, Member C 2 3
  • FAM44C 3 4
  • BOD1P 3 4
  • Putative Biorientation Of Chromosomes In Cell Division Protein 1 Pseudogene 3
  • Putative Biorientation Of Chromosomes In Cell Division Protein 1-Like 2 3
  • Biorientation Of Chromosomes In Cell Division Protein 1-Like 2 3
  • Putative Protein FAM44C 3
  • Protein FAM44C 4

External Ids for BOD1L2 Gene

Previous HGNC Symbols for BOD1L2 Gene

  • FAM44C
  • BOD1P

Previous GeneCards Identifiers for BOD1L2 Gene

  • GC18P054826
  • GC18P054831
  • GC18P054835
  • GC18P054840

Summaries for BOD1L2 Gene

GeneCards Summary for BOD1L2 Gene

BOD1L2 (Biorientation Of Chromosomes In Cell Division 1 Like 2) is a Protein Coding gene. An important paralog of this gene is BOD1.

UniProtKB/Swiss-Prot for BOD1L2 Gene

  • May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOD1L2 Gene

Genomics for BOD1L2 Gene

Regulatory Elements for BOD1L2 Gene

Enhancers for BOD1L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G057209 1 Ensembl ENCODE 11.4 +63.7 63667 2.2 PKNOX1 TAF1 JUN RAD21 RFX5 FOSL1 TCF12 NCOR1 ZBTB48 SMC3 BOD1L2 ST8SIA3 GC18P057154 PIR40352 GC18M057285
GH18G057208 0.6 ENCODE 10.9 +61.1 61103 0.2 TFAP4 ESRRA USF2 HNF4A SMAD4 MAFK RARA BOD1L2 PIR40352 GC18P057154 GC18M057285
GH18G057207 0.4 ENCODE 10.9 +60.3 60283 0.2 TEAD4 BOD1L2 PIR40352 GC18P057154 GC18M057285
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BOD1L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BOD1L2 Gene

Chromosome:
18
Start:
57,147,062 bp from pter
End:
57,150,408 bp from pter
Size:
3,347 bases
Orientation:
Plus strand

Genomic View for BOD1L2 Gene

Genes around BOD1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOD1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOD1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOD1L2 Gene

Proteins for BOD1L2 Gene

  • Protein details for BOD1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYS8-BD1L2_HUMAN
    Recommended name:
    Biorientation of chromosomes in cell division protein 1-like 2
    Protein Accession:
    Q8IYS8
    Secondary Accessions:
    • B3KXU4
    • Q8WW13

    Protein attributes for BOD1L2 Gene

    Size:
    172 amino acids
    Molecular mass:
    18075 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BOD1L2 Gene

Post-translational modifications for BOD1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BOD1L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BOD1L2 Gene

Domains & Families for BOD1L2 Gene

Protein Domains for BOD1L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BOD1L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYS8

UniProtKB/Swiss-Prot:

BD1L2_HUMAN :
  • Belongs to the BOD1 family.
Family:
  • Belongs to the BOD1 family.
genes like me logo Genes that share domains with BOD1L2: view

No data available for Gene Families for BOD1L2 Gene

Function for BOD1L2 Gene

Molecular function for BOD1L2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BOD1L2 Gene

Localization for BOD1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOD1L2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BOD1L2 gene
Compartment Confidence
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for BOD1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with BOD1L2: view

Pathways & Interactions for BOD1L2 Gene

SuperPathways for BOD1L2 Gene

No Data Available

Interacting Proteins for BOD1L2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000467843%0d%0a9606.ENSP00000309644%0d%0a
Selected Interacting proteins: ENSP00000467843 Q8IYS8-BD1L2_HUMAN for BOD1L2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for BOD1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with BOD1L2: view

No data available for Pathways by source and SIGNOR curated interactions for BOD1L2 Gene

Drugs & Compounds for BOD1L2 Gene

No Compound Related Data Available

Transcripts for BOD1L2 Gene

mRNA/cDNA for BOD1L2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BOD1L2 Gene

Biorientation of chromosomes in cell division 1-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BOD1L2 Gene

No ASD Table

Relevant External Links for BOD1L2 Gene

GeneLoc Exon Structure for
BOD1L2
ECgene alternative splicing isoforms for
BOD1L2

Expression for BOD1L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BOD1L2 Gene

mRNA differential expression in normal tissues according to GTEx for BOD1L2 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for BOD1L2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BOD1L2 Gene



Protein tissue co-expression partners for BOD1L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BOD1L2 Gene:

BOD1L2

SOURCE GeneReport for Unigene cluster for BOD1L2 Gene:

Hs.127882
genes like me logo Genes that share expression patterns with BOD1L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BOD1L2 Gene

Orthologs for BOD1L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BOD1L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BOD1L2 34 35
  • 99.79 (n)
mouse
(Mus musculus)
Mammalia Bod1 35
  • 77 (a)
OneToMany
cow
(Bos Taurus)
Mammalia BOD1 35
  • 71 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BOD1 35
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii bod1 35
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5514 35
  • 5 (a)
OneToMany
Species where no ortholog for BOD1L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOD1L2 Gene

ENSEMBL:
Gene Tree for BOD1L2 (if available)
TreeFam:
Gene Tree for BOD1L2 (if available)

Paralogs for BOD1L2 Gene

Paralogs for BOD1L2 Gene

(2) SIMAP similar genes for BOD1L2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for BOD1L2 Gene

genes like me logo Genes that share paralogs with BOD1L2: view

Variants for BOD1L2 Gene

Sequence variations from dbSNP and Humsavar for BOD1L2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000350033 -- 57,150,403(+) TTCTG(A/G)AATTC utr-variant-3-prime
rs1000450521 -- 57,148,305(+) TCAGA(A/G)TTGCA utr-variant-3-prime
rs1002901212 -- 57,150,660(+) AAGAG(A/G)CAGAG downstream-variant-500B
rs1003179374 -- 57,145,150(+) GGTAA(C/T)TTAAT upstream-variant-2KB
rs1003266131 -- 57,148,736(+) TGCTG(A/C)CCCGT utr-variant-3-prime

Variation tolerance for BOD1L2 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BOD1L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BOD1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BOD1L2 Gene

Disorders for BOD1L2 Gene

Relevant External Links for BOD1L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BOD1L2

No disorders were found for BOD1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOD1L2 Gene

Publications for BOD1L2 Gene

  1. Bod1, a novel kinetochore protein required for chromosome biorientation. (PMID: 17938248) Porter I.M. … Swedlow J.R. (J. Cell Biol. 2007) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for BOD1L2 Gene

Sources for BOD1L2 Gene

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