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Aliases for BOD1L1 Gene

Aliases for BOD1L1 Gene

  • Biorientation Of Chromosomes In Cell Division 1 Like 1 2 3 5
  • Biorientation Of Chromosomes In Cell Division 1-Like 2 3
  • Family With Sequence Similarity 44, Member A 2 3
  • FAM44A 3 4
  • BOD1L 3 4
  • Biorientation Of Chromosomes In Cell Division Protein 1-Like 1 3
  • KIAA1327 4

External Ids for BOD1L1 Gene

Previous HGNC Symbols for BOD1L1 Gene

  • FAM44A
  • BOD1L

Summaries for BOD1L1 Gene

GeneCards Summary for BOD1L1 Gene

BOD1L1 (Biorientation Of Chromosomes In Cell Division 1 Like 1) is a Protein Coding gene. An important paralog of this gene is BOD1.

UniProtKB/Swiss-Prot for BOD1L1 Gene

  • Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).

Additional gene information for BOD1L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOD1L1 Gene

Genomics for BOD1L1 Gene

Regulatory Elements for BOD1L1 Gene

Enhancers for BOD1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H013482 1.4 FANTOM5 ENCODE 10.3 +143.5 143523 2 PKNOX1 ATF1 ARNT ARID4B SIN3A BRCA1 YY1 GLIS2 ZNF207 ATF7 NKX3-2 BOD1L1 RAB28 GC04P013478
GH04H013597 0.8 dbSUPER 11.2 +26.3 26252 8 SOX13 CTCF PKNOX1 FOXA2 ZNF792 SAP130 CEBPG BATF RARA GATA3 BOD1L1 LOC100288683 LINC01096 PIR58938
GH04H013619 0.4 dbSUPER 10 +5.7 5702 4 FOXA2 BOD1L1 LINC01096 PIR58938
GH04H013625 1.4 ENCODE dbSUPER 0.7 +0.4 382 3 HDGF FOXA2 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LINC01096 LOC101929048 BOD1L1 PIR58938
GH04H013610 0.9 ENCODE dbSUPER 0.4 +15.9 15909 2 ZNF687 NR2F1 MAX BACH1 JUNB RELA RFX5 BCL11A POLR2A RUNX3 LOC100288683 LINC01096 PIR58938 BOD1L1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BOD1L1 on UCSC Golden Path with GeneCards custom track

Promoters for BOD1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000166043 23 2201 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for BOD1L1 Gene

Chromosome:
4
Start:
13,568,738 bp from pter
End:
13,627,723 bp from pter
Size:
58,986 bases
Orientation:
Minus strand

Genomic View for BOD1L1 Gene

Genes around BOD1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOD1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOD1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOD1L1 Gene

Proteins for BOD1L1 Gene

  • Protein details for BOD1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFC6-BD1L1_HUMAN
    Recommended name:
    Biorientation of chromosomes in cell division protein 1-like 1
    Protein Accession:
    Q8NFC6
    Secondary Accessions:
    • Q6P0M8
    • Q96AL1
    • Q9H6G0
    • Q9NTD6
    • Q9P2L9

    Protein attributes for BOD1L1 Gene

    Size:
    3051 amino acids
    Molecular mass:
    330466 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH16987.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15299.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAB70705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for BOD1L1 Gene

Post-translational modifications for BOD1L1 Gene

  • Ubiquitination at posLast=29812981 and posLast=29822982
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BOD1L1 Gene

Domains & Families for BOD1L1 Gene

Gene Families for BOD1L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BOD1L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BOD1L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFC6

UniProtKB/Swiss-Prot:

BD1L1_HUMAN :
  • Belongs to the BOD1 family.
Family:
  • Belongs to the BOD1 family.
genes like me logo Genes that share domains with BOD1L1: view

Function for BOD1L1 Gene

Molecular function for BOD1L1 Gene

UniProtKB/Swiss-Prot Function:
Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).

Phenotypes From GWAS Catalog for BOD1L1 Gene

genes like me logo Genes that share phenotypes with BOD1L1: view

Animal Model Products

CRISPR Products

miRNA for BOD1L1 Gene

miRTarBase miRNAs that target BOD1L1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BOD1L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOD1L1 Gene

Localization for BOD1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOD1L1 Gene

Chromosome. Note=Localizes at replication forks: following DNA damage, localizes to damaged replication forks undergoing resection. {ECO:0000269 Ref.2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BOD1L1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BOD1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with BOD1L1: view

Pathways & Interactions for BOD1L1 Gene

SuperPathways for BOD1L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BOD1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IDA,IEA 26166705
GO:0031297 replication fork processing IDA 26166705
genes like me logo Genes that share ontologies with BOD1L1: view

No data available for Pathways by source and SIGNOR curated interactions for BOD1L1 Gene

Drugs & Compounds for BOD1L1 Gene

No Compound Related Data Available

Transcripts for BOD1L1 Gene

Unigene Clusters for BOD1L1 Gene

Biorientation of chromosomes in cell division 1-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for BOD1L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for BOD1L1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: -

Relevant External Links for BOD1L1 Gene

GeneLoc Exon Structure for
BOD1L1
ECgene alternative splicing isoforms for
BOD1L1

Expression for BOD1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BOD1L1 Gene

Protein differential expression in normal tissues from HIPED for BOD1L1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.8), Adrenal (11.8), and Bone marrow mesenchymal stem cell (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BOD1L1 Gene



Protein tissue co-expression partners for BOD1L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BOD1L1 Gene:

BOD1L1

SOURCE GeneReport for Unigene cluster for BOD1L1 Gene:

Hs.744935

Evidence on tissue expression from TISSUES for BOD1L1 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
  • Liver(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with BOD1L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BOD1L1 Gene

Orthologs for BOD1L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BOD1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BOD1L1 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia BOD1L1 33 34
  • 82.18 (n)
cow
(Bos Taurus)
Mammalia BOD1L 33 34
  • 78.85 (n)
rat
(Rattus norvegicus)
Mammalia Bod1l1 33
  • 78.48 (n)
mouse
(Mus musculus)
Mammalia Bod1l 33 16 34
  • 78.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BOD1L1 34
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BOD1L 33
  • 62.51 (n)
BOD1L1 34
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BOD1L1 34
  • 34 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21296 33
zebrafish
(Danio rerio)
Actinopterygii BOD1L1 34
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5514 34
  • 16 (a)
OneToMany
Species where no ortholog for BOD1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOD1L1 Gene

ENSEMBL:
Gene Tree for BOD1L1 (if available)
TreeFam:
Gene Tree for BOD1L1 (if available)

Paralogs for BOD1L1 Gene

Paralogs for BOD1L1 Gene

(2) SIMAP similar genes for BOD1L1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BOD1L1: view

Variants for BOD1L1 Gene

Sequence variations from dbSNP and Humsavar for BOD1L1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_036124 A breast cancer sample
rs1000016956 -- 13,628,886(+) ATTAG(A/T)TTTGA upstream-variant-2KB
rs1000097589 -- 13,581,994(+) TGATC(C/T)TATCT intron-variant
rs1000126836 -- 13,623,291(+) ATGAA(C/T)GTTTG intron-variant
rs1000153971 -- 13,604,423(+) CTTTT(-/TTG)TTGTT cds-indel

Structural Variations from Database of Genomic Variants (DGV) for BOD1L1 Gene

Variant ID Type Subtype PubMed ID
esv3306712 CNV mobile element insertion 20981092
esv3439775 CNV insertion 20981092
nsv1014473 CNV gain 25217958
nsv4239 CNV insertion 18451855
nsv593750 CNV gain 21841781

Variation tolerance for BOD1L1 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BOD1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BOD1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BOD1L1 Gene

Disorders for BOD1L1 Gene

Relevant External Links for BOD1L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BOD1L1

No disorders were found for BOD1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOD1L1 Gene

Publications for BOD1L1 Gene

  1. BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks. (PMID: 26166705) Higgs MR … Stewart GS (Molecular cell 2015) 3 4 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 60

Products for BOD1L1 Gene

Sources for BOD1L1 Gene

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