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Aliases for BOD1L1 Gene

Aliases for BOD1L1 Gene

  • Biorientation Of Chromosomes In Cell Division 1 Like 1 2 3
  • Biorientation Of Chromosomes In Cell Division 1-Like 1 3 5
  • Family With Sequence Similarity 44, Member A 2 3
  • FAM44A 3 4
  • BOD1L 3 4
  • Biorientation Of Chromosomes In Cell Division 1-Like 2
  • KIAA1327 4

External Ids for BOD1L1 Gene

Previous HGNC Symbols for BOD1L1 Gene

  • FAM44A
  • BOD1L

Summaries for BOD1L1 Gene

GeneCards Summary for BOD1L1 Gene

BOD1L1 (Biorientation Of Chromosomes In Cell Division 1 Like 1) is a Protein Coding gene. Diseases associated with BOD1L1 include fanconi anemia, complementation group a. An important paralog of this gene is BOD1L2.

UniProtKB/Swiss-Prot for BOD1L1 Gene

  • Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOD1L1 Gene

Genomics for BOD1L1 Gene

Regulatory Elements for BOD1L1 Gene

Promoters for BOD1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BOD1L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BOD1L1 Gene

Chromosome:
4
Start:
13,568,738 bp from pter
End:
13,627,723 bp from pter
Size:
58,986 bases
Orientation:
Minus strand

Genomic View for BOD1L1 Gene

Genes around BOD1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOD1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOD1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOD1L1 Gene

Proteins for BOD1L1 Gene

  • Protein details for BOD1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFC6-BD1L1_HUMAN
    Recommended name:
    Biorientation of chromosomes in cell division protein 1-like 1
    Protein Accession:
    Q8NFC6
    Secondary Accessions:
    • Q6P0M8
    • Q96AL1
    • Q9H6G0
    • Q9NTD6
    • Q9P2L9

    Protein attributes for BOD1L1 Gene

    Size:
    3051 amino acids
    Molecular mass:
    330466 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH16987.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15299.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAB70705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for BOD1L1 Gene

Proteomics data for BOD1L1 Gene at MOPED

Post-translational modifications for BOD1L1 Gene

  • Ubiquitination at Lys 2981 and Lys 2982
  • Modification sites at PhosphoSitePlus

Other Protein References for BOD1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BOD1L1 Gene

Domains & Families for BOD1L1 Gene

Protein Domains for BOD1L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BOD1L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFC6

UniProtKB/Swiss-Prot:

BD1L1_HUMAN :
  • Contains 1 A.T hook DNA-binding domain.
  • Belongs to the BOD1 family.
Domain:
  • Contains 1 A.T hook DNA-binding domain.
Family:
  • Belongs to the BOD1 family.
genes like me logo Genes that share domains with BOD1L1: view

No data available for Gene Families for BOD1L1 Gene

Function for BOD1L1 Gene

Molecular function for BOD1L1 Gene

UniProtKB/Swiss-Prot Function:
Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).
genes like me logo Genes that share phenotypes with BOD1L1: view

Animal Model Products

CRISPR Products

miRNA for BOD1L1 Gene

miRTarBase miRNAs that target BOD1L1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOD1L1 Gene

Localization for BOD1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOD1L1 Gene

Chromosome. Note=Localizes at replication forks: following DNA damage, localizes to damaged replication forks undergoing resection. {ECO:0000269 Ref.2}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BOD1L1 Gene COMPARTMENTS Subcellular localization image for BOD1L1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for BOD1L1 Gene

Pathways & Interactions for BOD1L1 Gene

SuperPathways for BOD1L1 Gene

No Data Available

Interacting Proteins for BOD1L1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000040738%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000323588%0d%0a9606.ENSP00000360916%0d%0a
Selected Interacting proteins: Q8NFC6-BD1L1_HUMAN ENSP00000040738 for BOD1L1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for BOD1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031297 replication fork processing IDA 26166705
genes like me logo Genes that share ontologies with BOD1L1: view

No data available for Pathways by source and SIGNOR curated interactions for BOD1L1 Gene

Drugs & Compounds for BOD1L1 Gene

No Compound Related Data Available

Transcripts for BOD1L1 Gene

Unigene Clusters for BOD1L1 Gene

Biorientation of chromosomes in cell division 1-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BOD1L1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: -

Relevant External Links for BOD1L1 Gene

GeneLoc Exon Structure for
BOD1L1
ECgene alternative splicing isoforms for
BOD1L1

Expression for BOD1L1 Gene

mRNA expression in normal human tissues for BOD1L1 Gene

Protein differential expression in normal tissues from HIPED for BOD1L1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.8), Adrenal (11.8), and Bone marrow mesenchymal stem cell (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BOD1L1 Gene



SOURCE GeneReport for Unigene cluster for BOD1L1 Gene Hs.744935

genes like me logo Genes that share expression patterns with BOD1L1: view

Protein tissue co-expression partners for BOD1L1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BOD1L1 Gene

Orthologs for BOD1L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BOD1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BOD1L1 35
  • 99.52 (n)
  • 99.18 (a)
BOD1L1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BOD1L 36
  • 72 (a)
OneToOne
BOD1L 35
  • 78.85 (n)
  • 72.4 (a)
dog
(Canis familiaris)
Mammalia BOD1L1 35
  • 82.18 (n)
  • 75.86 (a)
BOD1L1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bod1l 16
Bod1l 35
  • 78.46 (n)
  • 70.23 (a)
Bod1l 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia BOD1L1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bod1l1 35
  • 78.48 (n)
  • 70.51 (a)
chicken
(Gallus gallus)
Aves BOD1L1 36
  • 40 (a)
OneToOne
BOD1L 35
  • 62.51 (n)
  • 51.54 (a)
lizard
(Anolis carolinensis)
Reptilia BOD1L1 36
  • 34 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21296 35
zebrafish
(Danio rerio)
Actinopterygii BOD1L1 36
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5514 36
  • 16 (a)
OneToMany
Species with no ortholog for BOD1L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOD1L1 Gene

ENSEMBL:
Gene Tree for BOD1L1 (if available)
TreeFam:
Gene Tree for BOD1L1 (if available)

Paralogs for BOD1L1 Gene

Paralogs for BOD1L1 Gene

(2) SIMAP similar genes for BOD1L1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BOD1L1: view

Variants for BOD1L1 Gene

Sequence variations from dbSNP and Humsavar for BOD1L1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2035820 - 13,613,550(+) CAGAC(A/G)TTACA reference, missense
rs1971278 - 13,604,952(+) TTCTA(A/T)TTTGG reference, missense
rs17745712 - 13,602,794(+) GGTGA(C/G)CTTCT reference, missense
rs17745676 - 13,602,558(+) TTCTG(C/T)ATTCA reference, missense
rs16888885 - 13,602,357(+) AGAAG(C/T)CTTTT reference, missense

Variation tolerance for BOD1L1 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BOD1L1 Gene

HapMap Linkage Disequilibrium report
BOD1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BOD1L1 Gene

Disorders for BOD1L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BOD1L1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fanconi anemia, complementation group a
  • fanconi's anemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BOD1L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BOD1L1
genes like me logo Genes that share disorders with BOD1L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BOD1L1 Gene

Publications for BOD1L1 Gene

  1. BOD1L is required to suppress deleterious resection of stressed replication forks. (PMID: 26166705) Higgs M.R. … Stewart G.S. (Mol. Cell 2015) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PMID: 18654987) Thalappilly S. … Dusetti N.J. (Proteomics 2008) 3

Products for BOD1L1 Gene

Sources for BOD1L1 Gene

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