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Aliases for BOD1 Gene

Aliases for BOD1 Gene

  • Biorientation Of Chromosomes In Cell Division 1 2 3 5
  • Family With Sequence Similarity 44, Member B 2 3
  • Biorientation Defective 1 2 3
  • FAM44B 3 4
  • Biorientation Of Chromosomes In Cell Division Protein 1 3
  • Biorientation Defective Protein 1 4
  • Protein FAM44B 4

External Ids for BOD1 Gene

Previous HGNC Symbols for BOD1 Gene

  • FAM44B

Previous GeneCards Identifiers for BOD1 Gene

  • GC05M172968
  • GC05M168131

Summaries for BOD1 Gene

GeneCards Summary for BOD1 Gene

BOD1 (Biorientation Of Chromosomes In Cell Division 1) is a Protein Coding gene. Diseases associated with BOD1 include Myoma. An important paralog of this gene is BOD1L2.

UniProtKB/Swiss-Prot for BOD1 Gene

  • Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOD1 Gene

Genomics for BOD1 Gene

Regulatory Elements for BOD1 Gene

Enhancers for BOD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G173752 1.5 Ensembl ENCODE dbSUPER 20.6 -136.4 -136381 2.9 BRCA1 ZNF48 YY2 REST SMARCB1 ZNF518A ZNF592 KAT8 MEF2D SMARCA4 BOD1 LINC01484 LINC01485
GH05G172918 1.2 ENCODE dbSUPER 19.8 +696.9 696906 4.3 PKNOX1 NFIB ZNF473 SIN3A YBX1 ZNF121 ZNF366 ELK1 SCRT2 FOS LOC100268168 UBTD2 BOD1 LOC100130394 ENSG00000254295 RPL26L1 SH3PXD2B DUSP1 LOC401218 LOC105377730
GH05G173777 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -163.7 -163679 7.4 HDGF FOXA2 PKNOX1 ARNT ZBTB7B YY1 ZNF766 FOS KLF13 REST CPEB4 BOD1 LINC01485 LINC01484
GH05G173757 2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -146.1 -146096 10.6 MLX CREB3L1 DMAP1 YY1 SLC30A9 MEF2D GLIS1 RCOR2 NBN NR2C1 C5orf47 BOD1 CPEB4 ATP6V0E1 LINC01484 LINC01485
GH05G173819 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -206.6 -206641 7.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 CPEB4 BOD1 LINC01485 PIR46909
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BOD1 on UCSC Golden Path with GeneCards custom track

Promoters for BOD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000190963 677 1601 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1

Genomic Location for BOD1 Gene

Chromosome:
5
Start:
173,607,145 bp from pter
End:
173,617,077 bp from pter
Size:
9,933 bases
Orientation:
Minus strand

Genomic View for BOD1 Gene

Genes around BOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOD1 Gene

Proteins for BOD1 Gene

  • Protein details for BOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IK1-BOD1_HUMAN
    Recommended name:
    Biorientation of chromosomes in cell division protein 1
    Protein Accession:
    Q96IK1
    Secondary Accessions:
    • B4DXH8
    • Q9BTW1

    Protein attributes for BOD1 Gene

    Size:
    185 amino acids
    Molecular mass:
    19196 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BOD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BOD1 Gene

Post-translational modifications for BOD1 Gene

  • Ubiquitination at Lys140
  • Modification sites at PhosphoSitePlus

Other Protein References for BOD1 Gene

No data available for DME Specific Peptides for BOD1 Gene

Domains & Families for BOD1 Gene

Protein Domains for BOD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BOD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96IK1

UniProtKB/Swiss-Prot:

BOD1_HUMAN :
  • Belongs to the BOD1 family.
Family:
  • Belongs to the BOD1 family.
genes like me logo Genes that share domains with BOD1: view

No data available for Gene Families for BOD1 Gene

Function for BOD1 Gene

Molecular function for BOD1 Gene

UniProtKB/Swiss-Prot Function:
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

Phenotypes for BOD1 Gene

genes like me logo Genes that share phenotypes with BOD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BOD1
  • Applied Biological Materials Clones for BOD1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOD1 Gene

Localization for BOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BOD1 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with BOD1: view

Pathways & Interactions for BOD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with BOD1: view

No data available for Pathways by source and SIGNOR curated interactions for BOD1 Gene

Drugs & Compounds for BOD1 Gene

No Compound Related Data Available

Transcripts for BOD1 Gene

Unigene Clusters for BOD1 Gene

Biorientation of chromosomes in cell division 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BOD1
  • Applied Biological Materials Clones for BOD1

Alternative Splicing Database (ASD) splice patterns (SP) for BOD1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - - - - - -
SP7:
SP8:

Relevant External Links for BOD1 Gene

GeneLoc Exon Structure for
BOD1
ECgene alternative splicing isoforms for
BOD1

Expression for BOD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BOD1 Gene

Protein differential expression in normal tissues from HIPED for BOD1 Gene

This gene is overexpressed in Plasma (36.1), Fetal Brain (15.7), and Fetal ovary (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BOD1 Gene



Protein tissue co-expression partners for BOD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of BOD1 Gene:

BOD1

SOURCE GeneReport for Unigene cluster for BOD1 Gene:

Hs.425091

Evidence on tissue expression from TISSUES for BOD1 Gene

  • Muscle(4.4)
  • Lung(4.3)
  • Blood(3.5)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with BOD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BOD1 Gene

Orthologs for BOD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BOD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BOD1 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia BOD1 34 35
  • 94.37 (n)
cow
(Bos Taurus)
Mammalia BOD1 34 35
  • 93.92 (n)
rat
(Rattus norvegicus)
Mammalia Bod1 34
  • 89.57 (n)
mouse
(Mus musculus)
Mammalia Bod1 34 16 35
  • 89.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves BOD1 34
  • 84.25 (n)
-- 35
  • 79 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bod1 34
  • 72.83 (n)
Str.4589 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3658 34
zebrafish
(Danio rerio)
Actinopterygii bod1 34 35
  • 72.63 (n)
wufb24f11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8879 34
fruit fly
(Drosophila melanogaster)
Insecta CG5514 35
  • 5 (a)
OneToMany
Species where no ortholog for BOD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOD1 Gene

ENSEMBL:
Gene Tree for BOD1 (if available)
TreeFam:
Gene Tree for BOD1 (if available)

Paralogs for BOD1 Gene

Paralogs for BOD1 Gene

(2) SIMAP similar genes for BOD1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for BOD1 Gene

genes like me logo Genes that share paralogs with BOD1: view

Variants for BOD1 Gene

Sequence variations from dbSNP and Humsavar for BOD1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000887395 -- 173,611,486(+) CAAGT(A/T)CATGT intron-variant
rs1001315661 -- 173,615,673(+) TTTAT(C/T)AATGA intron-variant
rs1001491903 -- 173,615,752(+) AATGA(A/G)CTAGA intron-variant
rs1001819665 -- 173,616,041(+) GCATC(C/G)CTCAG intron-variant
rs1001920017 -- 173,610,567(+) CGGCC(C/G)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BOD1 Gene

Variant ID Type Subtype PubMed ID
dgv3219n106 CNV deletion 24896259
esv2145234 CNV deletion 18987734
esv2184384 CNV deletion 18987734
esv2731116 CNV deletion 23290073
esv34083 CNV loss 18971310
nsv600298 CNV gain 21841781

Variation tolerance for BOD1 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BOD1 Gene

Human Gene Mutation Database (HGMD)
BOD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BOD1 Gene

Disorders for BOD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BOD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
myoma
  • benign neoplasm of the muscle
- elite association - COSMIC cancer census association via MalaCards
Search BOD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BOD1

Genetic Association Database (GAD)
BOD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BOD1
genes like me logo Genes that share disorders with BOD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BOD1 Gene

Publications for BOD1 Gene

  1. Bod1, a novel kinetochore protein required for chromosome biorientation. (PMID: 17938248) Porter I.M. … Swedlow J.R. (J. Cell Biol. 2007) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. BOD1 Is Required for Cognitive Function in Humans and Drosophila. (PMID: 27166630) Esmaeeli-Nieh S. … Kuss A.W. (PLoS Genet. 2016) 3 64
  4. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for BOD1 Gene

  • Addgene plasmids for BOD1

Sources for BOD1 Gene

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