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Aliases for BOD1 Gene

Aliases for BOD1 Gene

  • Biorientation Of Chromosomes In Cell Division 1 2 3 5
  • Family With Sequence Similarity 44, Member B 2 3
  • Biorientation Defective 1 2 3
  • FAM44B 3 4
  • Biorientation Of Chromosomes In Cell Division Protein 1 3
  • Biorientation Defective Protein 1 4
  • Protein FAM44B 4

External Ids for BOD1 Gene

Previous HGNC Symbols for BOD1 Gene

  • FAM44B

Previous GeneCards Identifiers for BOD1 Gene

  • GC05M172968
  • GC05M168131

Summaries for BOD1 Gene

GeneCards Summary for BOD1 Gene

BOD1 (Biorientation Of Chromosomes In Cell Division 1) is a Protein Coding gene. An important paralog of this gene is BOD1L2.

UniProtKB/Swiss-Prot for BOD1 Gene

  • Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOD1 Gene

Genomics for BOD1 Gene

Regulatory Elements for BOD1 Gene

Enhancers for BOD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BOD1 on UCSC Golden Path with GeneCards custom track

Promoters for BOD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for BOD1 Gene

Chromosome:
5
Start:
173,607,145 bp from pter
End:
173,617,077 bp from pter
Size:
9,933 bases
Orientation:
Minus strand

Genomic View for BOD1 Gene

Genes around BOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOD1 Gene

Proteins for BOD1 Gene

  • Protein details for BOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IK1-BOD1_HUMAN
    Recommended name:
    Biorientation of chromosomes in cell division protein 1
    Protein Accession:
    Q96IK1
    Secondary Accessions:
    • B4DXH8
    • Q9BTW1

    Protein attributes for BOD1 Gene

    Size:
    185 amino acids
    Molecular mass:
    19196 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BOD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BOD1 Gene

Post-translational modifications for BOD1 Gene

  • Ubiquitination at Lys 140
  • Modification sites at PhosphoSitePlus

Other Protein References for BOD1 Gene

No data available for DME Specific Peptides for BOD1 Gene

Domains & Families for BOD1 Gene

Protein Domains for BOD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BOD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96IK1

UniProtKB/Swiss-Prot:

BOD1_HUMAN :
  • Belongs to the BOD1 family.
Family:
  • Belongs to the BOD1 family.
genes like me logo Genes that share domains with BOD1: view

No data available for Gene Families for BOD1 Gene

Function for BOD1 Gene

Molecular function for BOD1 Gene

UniProtKB/Swiss-Prot Function:
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.

Phenotypes for BOD1 Gene

genes like me logo Genes that share phenotypes with BOD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BOD1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BOD1 Gene

Localization for BOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BOD1 Gene COMPARTMENTS Subcellular localization image for BOD1 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with BOD1: view

Pathways & Interactions for BOD1 Gene

SuperPathways for BOD1 Gene

No Data Available

Interacting Proteins for BOD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309644%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000309644 Q96IK1-BOD1_HUMAN for BOD1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for BOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with BOD1: view

No data available for Pathways by source and SIGNOR curated interactions for BOD1 Gene

Drugs & Compounds for BOD1 Gene

No Compound Related Data Available

Transcripts for BOD1 Gene

Unigene Clusters for BOD1 Gene

Biorientation of chromosomes in cell division 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BOD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BOD1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - - - - - -
SP7:
SP8:

Relevant External Links for BOD1 Gene

GeneLoc Exon Structure for
BOD1
ECgene alternative splicing isoforms for
BOD1

Expression for BOD1 Gene

mRNA expression in normal human tissues for BOD1 Gene

Protein differential expression in normal tissues from HIPED for BOD1 Gene

This gene is overexpressed in Plasma (36.1), Fetal Brain (15.7), and Fetal ovary (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BOD1 Gene



Protein tissue co-expression partners for BOD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of BOD1 Gene:

BOD1

SOURCE GeneReport for Unigene cluster for BOD1 Gene:

Hs.425091
genes like me logo Genes that share expression patterns with BOD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BOD1 Gene

Orthologs for BOD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BOD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BOD1 34
  • 93.92 (n)
  • 96.62 (a)
BOD1 35
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BOD1 34
  • 94.37 (n)
  • 96.62 (a)
BOD1 35
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Bod1 34
  • 89.19 (n)
  • 96.62 (a)
Bod1 16
Bod1 35
  • 88 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia BOD1 34
  • 99.82 (n)
  • 100 (a)
BOD1 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bod1 34
  • 89.57 (n)
  • 97.28 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves BOD1 34
  • 84.25 (n)
  • 92.47 (a)
-- 35
  • 79 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bod1 34
  • 72.83 (n)
  • 83.56 (a)
Str.4589 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3658 34
zebrafish
(Danio rerio)
Actinopterygii bod1 34
  • 72.63 (n)
  • 78.05 (a)
wufb24f11 34
bod1 35
  • 48 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8879 34
fruit fly
(Drosophila melanogaster)
Insecta CG5514 35
  • 5 (a)
OneToMany
Species where no ortholog for BOD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOD1 Gene

ENSEMBL:
Gene Tree for BOD1 (if available)
TreeFam:
Gene Tree for BOD1 (if available)

Paralogs for BOD1 Gene

Paralogs for BOD1 Gene

(2) SIMAP similar genes for BOD1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for BOD1 Gene

genes like me logo Genes that share paralogs with BOD1: view

Variants for BOD1 Gene

Sequence variations from dbSNP and Humsavar for BOD1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs166302 -- 173,611,035(-) TAAAC(A/G)ATGGA intron-variant
rs166303 -- 173,611,577(-) TCTCT(G/T)CATAG intron-variant
rs174051 -- 173,611,533(-) TTTTT(C/T)CCCTG intron-variant
rs189857 -- 173,611,543(-) TTGTT(G/T)TTTTT intron-variant
rs258855 -- 173,606,960(-) GTGCC(A/G)TATTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for BOD1 Gene

Variant ID Type Subtype PubMed ID
dgv3219n106 CNV deletion 24896259
esv2145234 CNV deletion 18987734
esv2184384 CNV deletion 18987734
esv2731116 CNV deletion 23290073
esv34083 CNV loss 18971310
nsv600298 CNV gain 21841781

Variation tolerance for BOD1 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BOD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BOD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BOD1 Gene

Disorders for BOD1 Gene

Relevant External Links for BOD1

Genetic Association Database (GAD)
BOD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BOD1

No disorders were found for BOD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOD1 Gene

Publications for BOD1 Gene

  1. Bod1, a novel kinetochore protein required for chromosome biorientation. (PMID: 17938248) Porter I.M. … Swedlow J.R. (J. Cell Biol. 2007) 2 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65

Products for BOD1 Gene

Sources for BOD1 Gene

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