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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BOC Gene

protein-coding   GIFtS: 58
GCID: GC03P112929

BOC Cell Adhesion Associated, Oncogene Regulated

(Previous name: Boc homolog (mouse))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BOC Cell Adhesion Associated, Oncogene Regulated1 2     Oncogene Regulated 21
Brother Of CDO1 2     CDON22
Brother Of CDON1 2     Boc Homolog2
Boc Homolog (Mouse)1     Cell Adhesion Associated, Oncogene Regulated 22
Cell Adhesion Associated1     Protein BOC3

External Ids:    HGNC: 171731   Entrez Gene: 916532   Ensembl: ENSG000001448577   OMIM: 6087085   UniProtKB: Q9BWV13   

Export aliases for BOC gene to outside databases

Previous GC identifers: GC03P109713 GC03P112500 GC03P114211 GC03P114251 GC03P114252 GC03P114413 GC03P110306


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BOC Gene:
The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a
component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells,
and promotes myogenic differentiation. (provided by RefSeq, Sep 2011)

GeneCards Summary for BOC Gene: 
BOC (BOC cell adhesion associated, oncogene regulated) is a protein-coding gene. Diseases associated with BOC include epiglottitis, and hereditary breast ovarian cancer, and among its related super-pathways are Myogenesis and Axon guidance. GO annotations related to this gene include protein binding. An important paralog of this gene is CDON.

UniProtKB/Swiss-Prot: BOC_HUMAN, Q9BWV1
Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle
precursor cells. Promotes differentiation of myogenic cells

Gene Wiki entry for BOC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BOC gene promoter:
         p53   MyoD   POU3F2   C/EBPalpha   CHOP-10   PPAR-gamma1   Nkx6-1   FOXO4   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBOC promoter sequence
   Search SABiosciences Chromatin IP Primers for BOC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BOC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

BOC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BOC gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P112929:  view genomic region     (about GC identifiers)

Start:
112,929,850 bp from pter      End:
113,006,306 bp from pter
Size:
76,457 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BOC_HUMAN, Q9BWV1 (See protein sequence)
Recommended Name: Brother of CDO precursor  
Size: 1114 amino acids; 121059 Da
Subunit: Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By
similarity). Interacts with CDH2 and CTNNB1. Interacts with CDH15 only during the early stages of myoblast
differentiation
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Enriched at sites of cell-cell
contact
Miscellaneous: The C-terminal cytoplasmic domain is not required for the stimuation of myogenesis
Sequence caution: Sequence=BAC11057.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for BOC:
3N1G (3D)        3N1M (3D)        3N1P (3D)    
Secondary accessions: A6NJ30 B2RMS8 D3DN70 Q6UXJ5 Q8N2P7 Q8NF26
Alternative splicing: 3 isoforms:  Q9BWV1-1   Q9BWV1-2   Q9BWV1-3   (No experimental confirmation available. Incomplete sequence)

Explore the universe of human proteins at neXtProt for BOC: NX_Q9BWV1

Explore proteomics data for BOC at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BWV1

  • BOC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BOC Protein Expression
    REFSEQ proteins: NP_150279.1  
    ENSEMBL proteins: 
     ENSP00000417362   ENSP00000418663   ENSP00000419022   ENSP00000420154   ENSP00000418118  
     ENSP00000273395   ENSP00000418260   ENSP00000417337   ENSP00000420056   ENSP00000418182  
     ENSP00000347546  
    Reactome Protein details: Q9BWV1
    Human Recombinant Protein Products for BOC: 
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    Novus Biologicals BOC Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BOC 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0030424axon ----
    GO:0030426growth cone ----
    GO:0043025neuronal cell body IEA--

    BOC for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for BOC 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5/6 InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q9BWV1

    ProtoNet protein and cluster: Q9BWV1

    2 Blocks protein domains:
    IPB002052 N-6 Adenine-specific DNA methylase
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: BOC_HUMAN, Q9BWV1
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    BOC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BOC_HUMAN, Q9BWV1
    Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle
    precursor cells. Promotes differentiation of myogenic cells

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11782431
         
    BOC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BOC:
     Decreased viability of wild-ty 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Boc):
     craniofacial  digestive/alimentary  limbs/digits/tail  mortality/aging  nervous system 
     normal  respiratory system  skeleton  vision/eye 

    BOC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Boctm1Aok for BOC

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BOC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BOC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BOC 
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    hsa-miR-519c-3p hsa-miR-519a hsa-miR-410 hsa-miR-519b-3p hsa-miR-4314 hsa-miR-338-5p hsa-miR-466 hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmidBOC 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BOC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2Axon guidance
    Developmental Biology0.69
    3Signaling events mediated by the Hedgehog family
    Signaling events mediated by the Hedgehog family

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for BOC
        Signaling events mediated by the Hedgehog family

    3        Reactome Pathways for BOC
        Developmental Biology
    Myogenesis
    CDO in myogenesis



    BOC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BOC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/11 Interacting proteins for BOC (Q9BWV13 ENSP000003475464) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDH2P190223, ENSP000002691414I2D: score=2 STRING: ENSP00000269141
    CDH15P552913, ENSP000002897464I2D: score=1 STRING: ENSP00000289746
    CDONQ4KMG03, ENSP000002635774I2D: score=2 STRING: ENSP00000263577
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    CTNNB1P352223, ENSP000003444564I2D: score=2 STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007224smoothened signaling pathway IEA--
    GO:0007411axon guidance IEA--
    GO:0030030cell projection organization ----
    GO:0042692muscle cell differentiation TAS--

    BOC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BOC

    Search CenterWatch for drugs/clinical trials and news about BOC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BOC gene: 
    NM_033254.2  

    Unigene Cluster for BOC:

    BOC cell adhesion associated, oncogene regulated
    Hs.591318  [show with all ESTs]
    Unigene Representative Sequence: NM_033254
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464546 ENST00000495514(uc003dzx.3) ENST00000498710 ENST00000485230(uc003dzw.1 uc003eaa.1)
    ENST00000462425 ENST00000273395 ENST00000494687 ENST00000471963(uc010hqi.3)
    ENST00000484034 ENST00000477178 ENST00000466059(uc003eab.3) ENST00000479182
    ENST00000497495 ENST00000463971 ENST00000488486 ENST00000473008 ENST00000355385(uc003dzy.3 uc003dzz.3 uc003eac.3)

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate BOC (see all 10):
    hsa-miR-519c-3p hsa-miR-519a hsa-miR-410 hsa-miR-519b-3p hsa-miR-4314 hsa-miR-338-5p hsa-miR-466 hsa-miR-130b*
    SwitchGear 3'UTR luciferase reporter plasmidBOC 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BOC

    Additional mRNA sequence: 

    AK056359.1 AK309055.1 AL133599.1 AY027658.1 AY358328.1 BC032071.1 BC034614.1 BC075829.1 
    BC136390.1 

    18 DOTS entries:

    DT.432861  DT.95241239  DT.86821334  DT.120854395  DT.95356243  DT.95188668  DT.453380  DT.95356242 
    DT.120854375  DT.65288168  DT.97824436  DT.100027217  DT.120854365  DT.100785739  DT.65288545  DT.87046331 
    DT.99935939  DT.120854351 

    24/33 AceView cDNA sequences (see all 33):

    AI333754 BC034614 BX109910 AK056359 BQ009631 AI382808 CA445904 BE674430 
    BU844759 BF447871 BU848962 BF512920 AI571379 BU855677 BU556830 R48752 
    AI870233 BE670724 AW024895 BG681148 BU623424 BE644731 CD243453 AI808913 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for BOC (see all 17)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a ·
    SP1:                    -     -     -     -     -     -           -                                                     -     -                 -           -   
    SP2:                                                              -                                                     -     -                 -           -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:              -     -     -     -     -     -     -           -                                                                                             

    ExUns: 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b
    SP1:                                      -           -                                                         
    SP2:                                      -           -                                                         
    SP3:                                      -           -                                                         
    SP4:                                      -           -                                                         
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for BOC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BOC expression in normal human tissues (normalized intensities)      BOC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAACAGACC
    BOC Expression
    About this image


    BOC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Metencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             brain/midbrain   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Epiphyseal End
             skeleton   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             spinal cord/lateral wall/ventricular layer   
     
     Nose (Sensory Organs)
             sensory organ/nose   

    See BOC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BOC

    SOURCE GeneReport for Unigene cluster: Hs.591318

    UniProtKB/Swiss-Prot: BOC_HUMAN, Q9BWV1
    Tissue specificity: Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower
    levels in brain, placenta, lung and colon mucosa

        SABiosciences Expression via Pathway-Focused PCR Array including BOC: 
              Hedgehog Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BOC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BOC gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Boc1 , 5 biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein less1, 5 84.52(n)1
    86.99(a)1
      16 (28.81 cM)5
    1176061  NM_172506.21  NP_766094.11 
     444850495 
    chicken
    (Gallus gallus)
    Aves BOC1 Boc homolog (mouse) 73.19(n)
    74.72(a)
      418361  XM_416581.3  XP_416581.2 
    lizard
    (Anolis carolinensis)
    Reptilia BOC6
    Uncharacterized protein
    70(a)
    1 ↔ 1
    3(176111564-176188967)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF388036.12   -- 78.91(n)    AF388036.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF461120.12   -- 75.45(n)    AF461120.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64906
    --
    14(a)
    1 → many
    3R(22295800-22360939)


    ENSEMBL Gene Tree for BOC (if available)
    TreeFam Gene Tree for BOC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BOC gene
    CDON2  NEO12  IGDCC42  FNDC3B2  SDK22  DCC2  SDK12  PRTG2  
    IGDCC32  FNDC3A2  
    1 SIMAP similar gene for BOC using alignment to 8 protein entries:     BOC_HUMAN (see all proteins):
    CDON

    BOC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1629 SNPs in BOC are shown (see all 1629)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355034
    A breast cancer sample4--see VAR_0355032 V M mis40--------
    rs130705731,2
    C--112929574(+) GGTGGG/AGCCCA 1 -- us2k17Minor allele frequency- A:0.15NA CSA WA EA 366
    rs43641411,2
    C,F--112929617(+) CTGCTA/GCAGAT 1 -- us2k111Minor allele frequency- G:0.09NA WA CSA EA 373
    rs76418801,2
    C,F,A--112929621(+) TGCAGA/CTCAAG 1 -- us2k18Minor allele frequency- C:0.44WA NA CSA EA 368
    rs76420611,2
    C,F,A--112929748(+) CCCCAG/ACCCCA 1 -- us2k110Minor allele frequency- A:0.10NA WA CSA EA 371
    rs765383381,2
    F--112929831(+) TGGACG/CACGCG 1 -- us2k12Minor allele frequency- C:0.13NA EA 240
    rs676686491,2
    C,F--112929836(+) GACGCG/AGCAAA 1 -- us2k15Minor allele frequency- A:0.13NA EA 246
    rs76226011,2
    C,F,H--112929929(+) CCGCTG/ATCCCA 1 -- us2k112Minor allele frequency- A:0.08NS NA WA 1706
    rs1817157571,2
    --112929976(+) AGTTTA/GTCTTG 1 -- us2k10--------
    rs1382086661,2
    --112929986(+) GCAGAA/GGAAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BOC (112929850 - 113006306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BOC:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5231n71CNV Gain21882294
    nsv829677CNV Gain17160897
    nsv877348CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608708    OMIM disorders: --

    11 diseases for BOC:    About MalaCards
    epiglottitis    hereditary breast ovarian cancer    diphtheria    tetanus
    pertussis    rhabdomyosarcoma    ovarian cancer    hepatitis c
    retinitis    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for BOC:
    Hepatitis C

    BOC for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: BOC (1 document)

    Export disorders for BOC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BOC gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with BOC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. (PubMed id 11782431)1, 2, 3 Kang J.-S.... Krauss R.S. (2002)
    2. Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. (PubMed id 12634428)1, 2, 9 Kang J.-S.... Krauss R.S. (2003)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Identification of 23 new prostate cancer susceptibilit y loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (2013)
    6. Genome-wide association scan of dental caries in the p ermanent dentition. (PubMed id 23259602)1 Wang X....Marazita M.L. (2012)
    7. All mammalian Hedgehog proteins interact with cell ad hesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. (PubMed id 20519495)1 Kavran J.M....Leahy D.J. (2010)
    8. A Three-Stage Genome-Wide Association Study of Genera l Cognitive Ability: Hunting the Small Effects. (PubMed id 20306291)1 Davis O.S....Plomin R. (2010)
    9. Segregation of ipsilateral retinal ganglion cell axon s at the optic chiasm requires the Shh receptor Boc. (PubMed id 20053908)1 Fabre P.J....Charron F. (2010)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91653 HGNC: 17173 AceView: BOC Ensembl:ENSG00000144857 euGenes: HUgn91653
    ECgene: BOC H-InvDB: BOC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BOC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BOC gene:
    Search GeneIP for patents involving BOC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in BOC promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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