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Aliases for BOC Gene

Aliases for BOC Gene

  • BOC Cell Adhesion Associated, Oncogene Regulated 2 3 5
  • Brother Of CDON 2 3
  • Cell Adhesion Associated, Oncogene Regulated 2 3
  • Cell Adhesion Associated 2
  • Oncogene Regulated 2 2
  • Boc Homolog (Mouse) 2
  • Brother Of CDO 2
  • Boc Homolog 3
  • Protein BOC 4
  • CDON2 3

External Ids for BOC Gene

Previous GeneCards Identifiers for BOC Gene

  • GC03P109713
  • GC03P112500
  • GC03P114211
  • GC03P114251
  • GC03P114252
  • GC03P114413
  • GC03P112929
  • GC03P110306

Summaries for BOC Gene

Entrez Gene Summary for BOC Gene

  • The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

GeneCards Summary for BOC Gene

BOC (BOC Cell Adhesion Associated, Oncogene Regulated) is a Protein Coding gene. Among its related pathways are Axon guidance and Developmental Biology. An important paralog of this gene is IGDCC3.

UniProtKB/Swiss-Prot for BOC Gene

  • Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.

Gene Wiki entry for BOC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOC Gene

Genomics for BOC Gene

Regulatory Elements for BOC Gene

Enhancers for BOC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BOC on UCSC Golden Path with GeneCards custom track

Promoters for BOC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BOC on UCSC Golden Path with GeneCards custom track

Genomic Location for BOC Gene

Chromosome:
3
Start:
113,211,003 bp from pter
End:
113,287,463 bp from pter
Size:
76,461 bases
Orientation:
Plus strand

Genomic View for BOC Gene

Genes around BOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOC Gene

Proteins for BOC Gene

  • Protein details for BOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWV1-BOC_HUMAN
    Recommended name:
    Brother of CDO
    Protein Accession:
    Q9BWV1
    Secondary Accessions:
    • A6NJ30
    • B2RMS8
    • D3DN70
    • Q6UXJ5
    • Q8N2P7
    • Q8NF26

    Protein attributes for BOC Gene

    Size:
    1114 amino acids
    Molecular mass:
    121059 Da
    Quaternary structure:
    • Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with SHH, DHH and IHH. Interacts with CDH2 and CTNNB1. Interacts with CDH15 only during the early stages of myoblast differentiation.
    Miscellaneous:
    • The C-terminal cytoplasmic domain is not required for the stimuation of myogenesis.
    SequenceCaution:
    • Sequence=BAC11057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BOC Gene

    Alternative splice isoforms for BOC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BOC Gene

Proteomics data for BOC Gene at MOPED

Post-translational modifications for BOC Gene

  • N-glycosylated.
  • Glycosylation at Asn 65, Asn 76, Asn 98, Asn 189, Asn 275, Asn 517, Asn 725, and Asn 759
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for BOC Gene

Domains & Families for BOC Gene

Suggested Antigen Peptide Sequences for BOC Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWV1

UniProtKB/Swiss-Prot:

BOC_HUMAN :
  • Contains 3 fibronectin type-III domains.
Domain:
  • Contains 3 fibronectin type-III domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with BOC: view

Function for BOC Gene

Molecular function for BOC Gene

UniProtKB/Swiss-Prot Function:
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
genes like me logo Genes that share phenotypes with BOC: view

Animal Models for BOC Gene

MGI Knock Outs for BOC:

Animal Model Products

  • Taconic Biosciences Mouse Models for BOC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BOC Gene

Localization for BOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOC Gene

Cell membrane; Single-pass type I membrane protein. Note=Enriched at sites of cell-cell contact.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BOC Gene COMPARTMENTS Subcellular localization image for BOC gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BOC: view

Pathways & Interactions for BOC Gene

genes like me logo Genes that share pathways with BOC: view

Pathways by source for BOC Gene

SIGNOR curated interactions for BOC Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for BOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007224 smoothened signaling pathway IEA --
GO:0007411 axon guidance IEA --
genes like me logo Genes that share ontologies with BOC: view

Drugs & Compounds for BOC Gene

No Compound Related Data Available

Transcripts for BOC Gene

Unigene Clusters for BOC Gene

BOC cell adhesion associated, oncogene regulated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BOC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a ·
SP1: - - - - - - - - - - -
SP2: - - - - -
SP3:
SP4:
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - -
SP9: - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - - - - -
SP12:
SP13: -
SP14:
SP15:
SP16: - - - - - -
SP17:

ExUns: 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for BOC Gene

GeneLoc Exon Structure for
BOC
ECgene alternative splicing isoforms for
BOC

Expression for BOC Gene

mRNA expression in normal human tissues for BOC Gene

mRNA differential expression in normal tissues according to GTEx for BOC Gene

This gene is overexpressed in Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for BOC Gene

This gene is overexpressed in Vitreous humor (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BOC Gene



SOURCE GeneReport for Unigene cluster for BOC Gene Hs.591318

mRNA Expression by UniProt/SwissProt for BOC Gene

Q9BWV1-BOC_HUMAN
Tissue specificity: Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa.
genes like me logo Genes that share expression patterns with BOC: view

Protein tissue co-expression partners for BOC Gene

Primer Products

Orthologs for BOC Gene

This gene was present in the common ancestor of animals.

Orthologs for BOC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BOC 35
  • 86.92 (n)
  • 89.23 (a)
BOC 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BOC 35
  • 88.51 (n)
  • 90.31 (a)
BOC 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Boc 35
  • 84.52 (n)
  • 86.99 (a)
Boc 16
Boc 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BOC 35
  • 97.5 (n)
  • 97.27 (a)
BOC 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Boc 35
  • 84.46 (n)
  • 86.54 (a)
oppossum
(Monodelphis domestica)
Mammalia BOC 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BOC 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves BOC 35
  • 73.05 (n)
  • 74.52 (a)
BOC 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BOC 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia boc 35
  • 69.05 (n)
  • 70.04 (a)
zebrafish
(Danio rerio)
Actinopterygii boc 35
  • 63.54 (n)
  • 62.5 (a)
boc 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta boi 36
  • 19 (a)
ManyToMany
ihog 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
Species with no ortholog for BOC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOC Gene

ENSEMBL:
Gene Tree for BOC (if available)
TreeFam:
Gene Tree for BOC (if available)

Paralogs for BOC Gene

Paralogs for BOC Gene

(1) SIMAP similar genes for BOC Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with BOC: view

Variants for BOC Gene

Sequence variations from dbSNP and Humsavar for BOC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs35536878 - 113,283,628(-) CTTTG(C/G)TTAGA reference, missense
rs3814405 - 113,284,426(+) CACCA(A/G/T)GCCAG reference, missense
VAR_035503 A breast cancer sample
rs712528 -- 113,270,756(+) GAAGT(A/T)TTCTG intron-variant
rs712529 -- 113,282,226(+) AGGGC(C/T)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BOC Gene

Variant ID Type Subtype PubMed ID
nsv829677 CNV Gain 17160897
dgv5231n71 CNV Gain 21882294
nsv877348 CNV Gain 21882294

Variation tolerance for BOC Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BOC Gene

Disorders for BOC Gene

Relevant External Links for BOC

Human Genome Epidemiology (HuGE) Navigator
BOC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BOC

No disorders were found for BOC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BOC Gene

Publications for BOC Gene

  1. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. (PMID: 11782431) Kang J.-S. … Krauss R.S. (EMBO J. 2002) 2 3 4 67
  2. Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. (PMID: 12634428) Kang J.-S. … Krauss R.S. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 23
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  4. Genome-wide association scan of dental caries in the permanent dentition. (PMID: 23259602) Wang X. … Marazita M.L. (BMC Oral Health 2012) 3
  5. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3

Products for BOC Gene

Sources for BOC Gene

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