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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BOC Gene

protein-coding GIFtS: 56
GCID: GC03P112929

BOC cell adhesion associated, oncogene regulated

(Previous name: Boc homolog (mouse) )

Explore 10 diseases affiliated with
BOC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BOC Cell Adhesion Associated, Oncogene Regulated¹ ²		Brother Of CDO²
CDON2¹ ²		Brother Of CDON²
Boc Homolog (Mouse)¹		Cell Adhesion Associated, Oncogene Regulated 2²
Boc Homolog²		Protein BOC³

External Ids:	HGNC: 17173¹	Entrez Gene: 91653²	Ensembl: ENSG00000144857⁷	OMIM: 608708⁵	UniProtKB: Q9BWV1³

Export aliases for BOC gene to outside databases

Previous GC identifers: GC03P109713 GC03P112500 GC03P114211 GC03P114251 GC03P114252 GC03P114413 GC03P110306

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BOC:

The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a

component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and

promotes myogenic differentiation. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: BOC_HUMAN, Q9BWV1

Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor

cells. Promotes differentiation of myogenic cells

Gene Wiki entry for BOC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BOC gene promoter:
p53 MyoD POU3F2 C/EBPalpha CHOP-10 PPAR-gamma1 Nkx6-1 FOXO4 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BOC promoter sequence

Search SABiosciences Chromatin IP Primers for BOC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BOC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2 Ensembl cytogenetic band: 3q13.2 HGNC cytogenetic band: 3q13.2

BOC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BOC gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P112929: view genomic region (about GC identifiers)

Start:	112,929,850 bp from pter	End:	113,006,306 bp from pter
Size:	76,457 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BOC_HUMAN, Q9BWV1 (See protein sequence)

Recommended Name: Brother of CDO precursor

Size: 1114 amino acids; 121059 Da

Subunit: Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity).

Interacts with CDH2 and CTNNB1. Interacts with CDH15 only during the early stages of myoblast differentiation

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Enriched at sites of cell-cell contact

Miscellaneous: The C-terminal cytoplasmic domain is not required for the stimuation of myogenesis

Sequence caution: Sequence=BAC11057.1; Type=Erroneous initiation;

3 PDB 3D structures from and Proteopedia for BOC:

3N1G (3D)

3N1M (3D)

3N1P (3D)

Secondary accessions: A6NJ30 B2RMS8 D3DN70 Q6UXJ5 Q8N2P7 Q8NF26

Alternative splicing: 3 isoforms: Q9BWV1-1 Q9BWV1-2 Q9BWV1-3 (No experimental confirmation available. Incomplete sequence)

Explore the universe of human proteins at neXtProt for BOC: NX_Q9BWV1

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BWV1

BOC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_150279.1

ENSEMBL proteins:

ENSP00000417362 ENSP00000418663 ENSP00000419022 ENSP00000420154 ENSP00000418118

ENSP00000273395 ENSP00000418260 ENSP00000417337 ENSP00000420056 ENSP00000418182

ENSP00000347546

Reactome Protein details: Q9BWV1
Human Recombinant Protein Products:

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	Uscn Proteins for BOC

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0030424	axon	--	--
GO:0030426	growth cone	--	--
GO:0043025	neuronal cell body	IEA	--

BOC for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BOC for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003598 Ig_sub2

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR003961 Fibronectin_type3

IPR013098 Ig_I-set

Graphical View of Domain Structure for InterPro Entry Q9BWV1

ProtoNet protein and cluster: Q9BWV1

2 Blocks protein families:

IPB002052 N-6 Adenine-specific DNA methylase

IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: BOC_HUMAN, Q9BWV1

Similarity: Contains 3 fibronectin type-III domains

Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BOC_HUMAN, Q9BWV1

Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor

cells. Promotes differentiation of myogenic cells

miRNA Products:		OriGene 3'-UTR Clone: BOC Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BOC
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate BOC (see all 10):
		hsa-miR-519c-3p hsa-miR-519a hsa-miR-410 hsa-miR-519b-3p hsa-miR-4314 hsa-miR-338-5p hsa-miR-466 hsa-miR-130b*

		SwitchGear 3'UTR luciferase reporter plasmid: BOC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BOC (see all 7) OriGene shRNA RFP: BOC OriGene siRNA: BOC
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BOC
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BOC

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11782431

BOC for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for BOC:

Decreased viability of wild-ty

Animal Models:
Mouse knock-out Boc^tm1Aok for BOC
9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Boc):

craniofacial	digestive/alimentary	limbs/digits/tail	mortality/aging	nervous system
normal	respiratory system	skeleton	vision/eye

BOC for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of p38 alpha/beta MAPK

	Activation of p38 alpha/beta MAPK	1.00			CDO in myogenesis	0.55
	Nuclear translocation of p38 MAPK	0.94			Myogenesis	0.55

Signaling events mediated by the Hedgehog family

Signaling events mediated by the Hedgehog family

1.00

Axon guidance

Developmental Biology

0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for BOC

Signaling events mediated by the Hedgehog family

5 Reactome Pathways for BOC

	Activation of p38 alpha/beta MAPK
	Developmental Biology
	Myogenesis
	Nuclear translocation of p38 MAPK
	CDO in myogenesis

BOC for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BOC

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/11 Interacting proteins for BOC (Q9BWV1³ ENSP00000347546⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDH2	P19022³, ENSP00000269141⁴	I2D: score=2 STRING: ENSP00000269141
CDH15	P55291³, ENSP00000289746⁴	I2D: score=1 STRING: ENSP00000289746
CDON	Q4KMG0³, ENSP00000263577⁴	I2D: score=2 STRING: ENSP00000263577
CDH1	P12830³, ENSP00000261769⁴	I2D: score=1 STRING: ENSP00000261769
CTNNB1	P35222³, ENSP00000344456⁴	I2D: score=2 STRING: ENSP00000344456

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0007224	smoothened signaling pathway	IEA	--
GO:0007411	axon guidance	IEA	--
GO:0030030	cell projection organization	--	--
GO:0042692	muscle cell differentiation	TAS	--

BOC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BOC
Search CenterWatch for drugs/clinical trials and news about BOC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BOC gene:

NM_033254.2

Unigene Cluster for BOC:

BOC cell adhesion associated, oncogene regulated

Hs.591318 [show with all ESTs]

Unigene Representative Sequence: NM_033254

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000464546 ENST00000495514(uc003dzx.3) ENST00000498710 ENST00000485230(uc003dzw.1 uc003eaa.1)

ENST00000462425 ENST00000273395 ENST00000494687 ENST00000471963(uc010hqi.3)

ENST00000484034 ENST00000477178 ENST00000466059(uc003eab.3) ENST00000479182

ENST00000497495 ENST00000463971 ENST00000488486 ENST00000473008 ENST00000355385(uc003dzy.3 uc003dzz.3 uc003eac.3)

miRNA Products:		OriGene 3'-UTR Clone: BOC Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BOC
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate BOC (see all 10):
		hsa-miR-519c-3p hsa-miR-519a hsa-miR-410 hsa-miR-519b-3p hsa-miR-4314 hsa-miR-338-5p hsa-miR-466 hsa-miR-130b*

		SwitchGear 3'UTR luciferase reporter plasmid: BOC 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: BOC (NM_033254)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BOC

Additional cDNA sequence:

AK056359.1 AK309055.1 AL133599.1 AY027658.1 AY358328.1 BC032071.1 BC034614.1 BC075829.1

BC136390.1

18 DOTS entries:

DT.432861 DT.95241239 DT.86821334 DT.120854395 DT.95188668 DT.95356243 DT.453380 DT.95356242

DT.120854375 DT.65288168 DT.97824436 DT.120854365 DT.100785739 DT.65288545 DT.87046331 DT.99935939

DT.100027217 DT.120854351

24/33 AceView cDNA sequences (see all 33):

BC034614 AK056359 AI333754 AI382808 BQ009631 BX109910 BE644731 BG681148

BU848962 BU855677 BE674430 CD243453 R48752 BF447871 BU844759 BU623424

BU556830 AI571379 BE670724 BF512920 AW024895 CA445904 AI870233 W79688

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for BOC (see all 17) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f	·	8g	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·
SP1:							-		-		-		-		-		-				-																		-		-						-				-
SP2:																					-																		-		-						-				-
SP3:
SP4:
SP5:					-		-		-		-		-		-		-				-

ExUns:	12b	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20	^	21	^	22	^	23	^	24	^	25a	·	25b
SP1:													-				-
SP2:													-				-
SP3:													-				-
SP4:													-				-
SP5:

ECgene alternative splicing isoforms for BOC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BOC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAACAGACC

About this image

BOC expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Bone

Brain

Medulla Oblongata

Brain

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Telencephalon

Neural Tube

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See BOC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BOC

SOURCE GeneReport for Unigene cluster: Hs.591318

UniProtKB/Swiss-Prot: BOC_HUMAN, Q9BWV1

Tissue specificity: Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in

brain, placenta, lung and colon mucosa

SABiosciences Expression via Pathway-Focused PCR Array including BOC:

Hedgehog Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BOC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for BOC gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BOC¹	Boc homolog (mouse)	73.19(n) 74.72(a)		418361 XM_416581.3 XP_416581.2
lizard (Anolis carolinensis)	Reptilia	BOC⁶	--	70(a)	1 ↔ 1	3(176149223-176184230)
African clawed frog (Xenopus laevis)	Amphibia	AF388036.1²	--	78.91(n)		AF388036.1
zebrafish (Danio rerio)	Actinopterygii	AF461120.1²	--	75.45(n)		AF461120.1
fruit fly (Drosophila melanogaster)	Insecta	sdk⁶ ihog⁶ (see all 3)	interference hedgehog (see all 3)	6(a) 19(a) (see all 3)	possible ortholog many ↔ many (see all 3)	X(580873-643529) 2L(6945464-6948808)

ENSEMBL Gene Tree for BOC (if available)
TreeFam Gene Tree for BOC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BOC gene

CDON² ROBO2² ROBO1² NEO1² ROBO4² IGDCC4² DCC² PRTG²

IGDCC3² ROBO3²

1 SIMAP similar gene for BOC using alignment to 8 protein entries: BOC_HUMAN (see all proteins):

CDON

BOC for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13070573^1,2	C,	--	112929574(+)	`GGTGGG/AGCCCA`	1	--	us2k¹		7		NA CSA WA EA	366
rs4364141^1,2	C,F,	--	112929617(+)	`CTGCTA/GCAGAT`	1	--	us2k¹		11		NA WA CSA EA	373
rs7641880^1,2	C,F,A,	--	112929621(+)	`TGCAGA/CTCAAG`	1	--	us2k¹		8		WA NA CSA EA	368
rs7642061^1,2	C,F,A,	--	112929748(+)	`CCCCAG/ACCCCA`	1	--	us2k¹		10		NA WA CSA EA	371
rs76538338^1,2	F,	--	112929831(+)	`TGGACG/CACGCG`	1	--	us2k¹		2		NA EA	240
rs67668649^1,2	C,F,	--	112929836(+)	`GACGCG/AGCAAA`	1	--	us2k¹		5		NA EA	246
rs7622601^1,2	C,F,H,	--	112929929(+)	`CCGCTG/ATCCCA`	1	--	us2k¹		12		NS NA WA	1706
rs181715757^1,2		--	112929976(+)	`AGTTTA/GTCTTG`	1	--	us2k¹		0	--	--	--	--
rs138208666^1,2		--	112929986(+)	`GCAGAA/GGAAGA`	1	--	us2k¹		0	--	--	--	--
rs150514008^1,2		--	112930064(+)	`CATGGA/CAGAGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BOC (112929850 - 113006306 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BOC: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BOC

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BOC for disorders           About GeneDecksing

OMIM gene information: 608708    OMIM disorders: --

10 diseases for BOC:    About MalaCards

breast-ovarian cancer epiglottitis hereditary breast ovarian cancer ovarian cancer

diphtheria tetanus rhabdomyosarcoma pertussis

retinitis neuronitis

1 disease from the University of Copenhagen DISEASES database for BOC:

Hepatitis C

Human Genome Epidemiology (HuGE) Navigator: BOC (1 document)

Export disorders for BOC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BOC gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with BOC)

Utopia: connect your pdf to the dynamic
world of online information

BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. (PubMed id 11782431)^{1, 2, 3} Kang J.-S.... Krauss R.S. (2002)
Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. (PubMed id 12634428)^{1, 2, 9} Kang J.-S.... Krauss R.S. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
All mammalian Hedgehog proteins interact with cell ad hesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. (PubMed id 20519495)¹ Kavran J.M....Leahy D.J. (2010)
A Three-Stage Genome-Wide Association Study of Genera l Cognitive Ability: Hunting the Small Effects. (PubMed id 20306291)¹ Davis O.S....Plomin R. (2010)
Segregation of ipsilateral retinal ganglion cell axon s at the optic chiasm requires the Shh receptor Boc. (PubMed id 20053908)¹ Fabre P.J....Charron F. (2010)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. (PubMed id 16647304)¹ Tenzen T....McMahon A.P. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 91653	HGNC: 17173	AceView: BOC	Ensembl:ENSG00000144857	euGenes: HUgn91653
ECgene: BOC	H-InvDB: BOC

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BOC	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BOC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for BOC gene:
Search GeneIP for patents involving BOC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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