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Aliases for BOC Gene

Aliases for BOC Gene

  • BOC Cell Adhesion Associated, Oncogene Regulated 2 3
  • Brother Of CDON 2 3
  • Brother Of CDO 2 3
  • Cell Adhesion Associated, Oncogene Regulated 2 3
  • Cell Adhesion Associated 2
  • Oncogene Regulated 2 2
  • Boc Homolog (Mouse) 2
  • Boc Homolog 3
  • Protein BOC 4
  • CDON2 3

External Ids for BOC Gene

Previous GeneCards Identifiers for BOC Gene

  • GC03P109713
  • GC03P112500
  • GC03P114211
  • GC03P114251
  • GC03P114252
  • GC03P114413
  • GC03P112929
  • GC03P110306

Summaries for BOC Gene

Entrez Gene Summary for BOC Gene

  • The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

GeneCards Summary for BOC Gene

BOC (BOC Cell Adhesion Associated, Oncogene Regulated) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Signaling events mediated by the Hedgehog family. An important paralog of this gene is CDON.

UniProtKB/Swiss-Prot for BOC Gene

  • Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells

Gene Wiki entry for BOC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BOC Gene

Genomics for BOC Gene

Regulatory Elements for BOC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BOC Gene

113,211,003 bp from pter
113,287,459 bp from pter
76,457 bases
Plus strand

Genomic View for BOC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BOC Gene

Proteins for BOC Gene

  • Protein details for BOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brother of CDO
    Protein Accession:
    Secondary Accessions:
    • A6NJ30
    • B2RMS8
    • D3DN70
    • Q6UXJ5
    • Q8N2P7
    • Q8NF26

    Protein attributes for BOC Gene

    1114 amino acids
    Molecular mass:
    121059 Da
    Quaternary structure:
    • Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with SHH, DHH and IHH. Interacts with CDH2 and CTNNB1. Interacts with CDH15 only during the early stages of myoblast differentiation.
    • The C-terminal cytoplasmic domain is not required for the stimuation of myogenesis
    • Sequence=BAC11057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BOC Gene

    Alternative splice isoforms for BOC Gene


neXtProt entry for BOC Gene

Proteomics data for BOC Gene at MOPED

Post-translational modifications for BOC Gene

  • N-glycosylated.
  • Glycosylation at Asn65, Asn76, Asn98, Asn189, Asn275, Asn517, Asn725, and Asn759
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BOC Gene

Domains for BOC Gene

Gene Families for BOC Gene

  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing

Suggested Antigen Peptide Sequences for BOC Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BWV1
  • Contains 3 fibronectin type-III domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with BOC: view

Function for BOC Gene

Molecular function for BOC Gene

UniProtKB/Swiss-Prot Function: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells

Gene Ontology (GO) - Molecular Function for BOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11782431
genes like me logo Genes that share ontologies with BOC: view
genes like me logo Genes that share phenotypes with BOC: view

Animal Models for BOC Gene

MGI Knock Outs for BOC:

Animal Model Products

CRISPR Products

miRNA for BOC Gene

miRTarBase miRNAs that target BOC

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BOC Gene

Localization for BOC Gene

Subcellular locations from UniProtKB/Swiss-Prot for BOC Gene

Cell membrane; Single-pass type I membrane protein. Note=Enriched at sites of cell-cell contact.

Subcellular locations from

Jensen Localization Image for BOC Gene COMPARTMENTS Subcellular localization image for BOC gene
Compartment Confidence
plasma membrane 5
nucleus 3
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for BOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon --
GO:0030426 growth cone --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with BOC: view

Pathways for BOC Gene

genes like me logo Genes that share pathways with BOC: view

Pathways by source for BOC Gene

1 BioSystems pathway for BOC Gene
3 Reactome pathways for BOC Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007224 smoothened signaling pathway IEA --
GO:0007411 axon guidance IEA --
GO:0030030 cell projection organization --
GO:0042692 muscle cell differentiation TAS --
genes like me logo Genes that share ontologies with BOC: view

Transcripts for BOC Gene

Unigene Clusters for BOC Gene

BOC cell adhesion associated, oncogene regulated:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BOC

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BOC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BOC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a ·
SP1: - - - - - - - - - - -
SP2: - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - -
SP9: - -
SP10: - - - - - - - - - - - - - - - - -
SP11: - - - - -
SP13: -
SP16: - - - - - -

ExUns: 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b
SP1: - -
SP2: - -
SP3: - -
SP4: - -

Relevant External Links for BOC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BOC Gene

mRNA expression in normal human tissues for BOC Gene

mRNA differential expression in normal tissues according to GTEx for BOC Gene

This gene is overexpressed in Fallopian Tube (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BOC Gene

SOURCE GeneReport for Unigene cluster for BOC Gene Hs.591318

mRNA Expression by UniProt/SwissProt for BOC Gene

Tissue specificity: Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa.
genes like me logo Genes that share expressions with BOC: view

In Situ Assay Products

Orthologs for BOC Gene

This gene was present in the common ancestor of animals.

Orthologs for BOC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BOC 35
  • 97.5 (n)
  • 97.27 (a)
BOC 36
  • 98 (a)
(Bos Taurus)
Mammalia BOC 35
  • 86.92 (n)
  • 89.23 (a)
BOC 36
  • 89 (a)
(Canis familiaris)
Mammalia BOC 35
  • 88.51 (n)
  • 90.31 (a)
BOC 36
  • 90 (a)
(Mus musculus)
Mammalia Boc 35
  • 84.52 (n)
  • 86.99 (a)
Boc 16
Boc 36
  • 87 (a)
(Monodelphis domestica)
Mammalia BOC 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia BOC 36
  • 69 (a)
(Rattus norvegicus)
Mammalia Boc 35
  • 84.46 (n)
  • 86.54 (a)
(Gallus gallus)
Aves BOC 35
  • 73.05 (n)
  • 74.52 (a)
BOC 36
  • 73 (a)
(Anolis carolinensis)
Reptilia BOC 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia boc 35
  • 69.05 (n)
  • 70.04 (a)
(Danio rerio)
Actinopterygii boc 35
  • 63.54 (n)
  • 62.5 (a)
boc 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta boi 36
  • 19 (a)
ihog 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
-- 36
  • 35 (a)
Species with no ortholog for BOC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BOC Gene

Gene Tree for BOC (if available)
Gene Tree for BOC (if available)

Paralogs for BOC Gene

Paralogs for BOC Gene

Selected SIMAP similar genes for BOC Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with BOC: view

Variants for BOC Gene

Sequence variations from dbSNP and Humsavar for BOC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs712528 -- 113,270,756(+) GAAGT(A/T)TTCTG intron-variant
rs712529 -- 113,282,226(+) AGGGC(C/T)GTCAG intron-variant
rs775219 -- 113,254,270(+) AAGGC(A/G)AAATG intron-variant
rs775220 -- 113,255,895(+) TGGAA(A/G)AAACA intron-variant
rs775221 -- 113,284,036(+) ATCTG(C/G)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BOC Gene

Variant ID Type Subtype PubMed ID
nsv829677 CNV Gain 17160897
dgv5231n71 CNV Gain 21882294
nsv877348 CNV Gain 21882294

Relevant External Links for BOC Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BOC Gene

Disorders for BOC Gene

(1) University of Copenhagen DISEASES for BOC Gene

Relevant External Links for BOC

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BOC: view

No data available for UniProtKB/Swiss-Prot for BOC Gene

Publications for BOC Gene

  1. Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. (PMID: 12634428) Kang J.-S. … Krauss R.S. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  2. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. (PMID: 11782431) Kang J.-S. … Krauss R.S. (EMBO J. 2002) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. (PMID: 20519495) Kavran J.M. … Leahy D.J. (J. Biol. Chem. 2010) 3 4

Products for BOC Gene

Sources for BOC Gene

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