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Aliases for BNIPL Gene

Aliases for BNIPL Gene

  • BCL2/Adenovirus E1B 19kD Interacting Protein Like 2 3
  • BNIPL1 3 6
  • BNIPL2 3 6
  • BNIPS 3 6
  • Bcl-2/Adenovirus E1B 19 KDa-Interacting Protein 2-Like Protein 3
  • BNIP-2 Similar 3
  • BNIPL-1 3
  • BNIPL-2 3
  • BNIP-S 3
  • PP753 3

External Ids for BNIPL Gene

Previous GeneCards Identifiers for BNIPL Gene

  • GC00U991195
  • GC01P148225
  • GC01P148188
  • GC01P147822
  • GC01P149275
  • GC01P122386

Summaries for BNIPL Gene

Entrez Gene Summary for BNIPL Gene

  • The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for BNIPL Gene

BNIPL (BCL2/Adenovirus E1B 19kD Interacting Protein Like) is a Protein Coding gene. Diseases associated with BNIPL include trigeminal neuralgia and hepatocellular carcinoma. GO annotations related to this gene include identical protein binding. An important paralog of this gene is PRR5-ARHGAP8.

UniProtKB/Swiss-Prot for BNIPL Gene

  • May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.

Gene Wiki entry for BNIPL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNIPL Gene

Genomics for BNIPL Gene

Regulatory Elements for BNIPL Gene

Genomic Location for BNIPL Gene

151,036,553 bp from pter
151,047,600 bp from pter
11,048 bases
Plus strand

Genomic View for BNIPL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BNIPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIPL Gene

Proteins for BNIPL Gene

  • Protein details for BNIPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6DK43
    • Q8TCY7
    • Q8WYG2

    Protein attributes for BNIPL Gene

    357 amino acids
    Molecular mass:
    39713 Da
    Quaternary structure:
    • Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER.

    Alternative splice isoforms for BNIPL Gene


neXtProt entry for BNIPL Gene

Proteomics data for BNIPL Gene at MOPED

Post-translational modifications for BNIPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BNIPL Gene

No data available for DME Specific Peptides for BNIPL Gene

Domains for BNIPL Gene

Protein Domains for BNIPL Gene

Suggested Antigen Peptide Sequences for BNIPL Gene

Graphical View of Domain Structure for InterPro Entry



  • Q7Z465
  • Contains 1 CRAL-TRIO domain.
genes like me logo Genes that share domains with BNIPL: view

No data available for Gene Families for BNIPL Gene

Function for BNIPL Gene

Molecular function for BNIPL Gene

UniProtKB/Swiss-Prot Function: May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.

Gene Ontology (GO) - Molecular Function for BNIPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12681488
GO:0042802 identical protein binding IPI 12901880
genes like me logo Genes that share ontologies with BNIPL: view

Phenotypes for BNIPL Gene

genes like me logo Genes that share phenotypes with BNIPL: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BNIPL Gene

Localization for BNIPL Gene

Subcellular locations from

Jensen Localization Image for BNIPL Gene COMPARTMENTS Subcellular localization image for BNIPL gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for BNIPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11741952
GO:0005829 cytosol IDA 11741952
genes like me logo Genes that share ontologies with BNIPL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BNIPL Gene

Pathways for BNIPL Gene

SuperPathways for BNIPL Gene

No Data Available

Gene Ontology (GO) - Biological Process for BNIPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 11741952
GO:0008285 negative regulation of cell proliferation IDA 12681488
GO:0040009 regulation of growth rate IDA 12681488
genes like me logo Genes that share ontologies with BNIPL: view

No data available for Pathways by source for BNIPL Gene

Transcripts for BNIPL Gene

Unigene Clusters for BNIPL Gene

BCL2/adenovirus E1B 19kD interacting protein like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BNIPL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - - -
SP4: - - - - -

Relevant External Links for BNIPL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BNIPL Gene

mRNA expression in normal human tissues for BNIPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BNIPL Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (12.6), Skin - Not Sun Exposed (Suprapubic) (12.1), Esophagus - Mucosa (11.2), and Vagina (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BNIPL Gene

SOURCE GeneReport for Unigene cluster for BNIPL Gene Hs.591473

mRNA Expression by UniProt/SwissProt for BNIPL Gene

Tissue specificity: Isoform 2 is expressed in placenta and lung.
genes like me logo Genes that share expressions with BNIPL: view

Orthologs for BNIPL Gene

This gene was present in the common ancestor of animals.

Orthologs for BNIPL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BNIPL 35
  • 99.63 (n)
  • 99.44 (a)
  • 99 (a)
(Bos Taurus)
Mammalia BNIPL 35
  • 88.64 (n)
  • 88.17 (a)
  • 88 (a)
(Canis familiaris)
Mammalia BNIPL 35
  • 87.89 (n)
  • 85.88 (a)
  • 84 (a)
(Mus musculus)
Mammalia Bnipl 35
  • 84.23 (n)
  • 85.35 (a)
Bnipl 16
Bnipl 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia BNIPL 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Bnipl 35
  • 84.32 (n)
  • 85.92 (a)
(Anolis carolinensis)
Reptilia BNIPL 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bnipl 35
  • 59.04 (n)
  • 52.98 (a)
(Danio rerio)
Actinopterygii bnipl 35
  • 55.62 (n)
  • 47.19 (a)
bnipl 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11593 36
  • 22 (a)
Species with no ortholog for BNIPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BNIPL Gene

Gene Tree for BNIPL (if available)
Gene Tree for BNIPL (if available)

Paralogs for BNIPL Gene

Paralogs for BNIPL Gene

Selected SIMAP similar genes for BNIPL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BNIPL: view

Variants for BNIPL Gene

Sequence variations from dbSNP and Humsavar for BNIPL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs955955 -- 151,039,067(+) TAGAG(A/G)CTAGA intron-variant
rs1534058 -- 151,037,213(+) GGCCT(A/G)ACTAG intron-variant
rs1534059 -- 151,037,243(+) GCTCA(A/G)TGATA intron-variant
rs1969442 -- 151,037,158(+) TCCAC(C/T)TATGC intron-variant
rs2091219 -- 151,039,584(-) ATACT(C/T)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BNIPL Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680
esv1745722 CNV Insertion 17803354

Relevant External Links for BNIPL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BNIPL Gene

Disorders for BNIPL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for BNIPL Gene including...

Search for BNIPL Gene in MalaCards »

(1) University of Copenhagen DISEASES for BNIPL Gene

(1) Novoseek inferred disease relationships for BNIPL Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 35 2

Relevant External Links for BNIPL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BNIPL: view

No data available for UniProtKB/Swiss-Prot for BNIPL Gene

Publications for BNIPL Gene

  1. The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence. (PMID: 11741952) Zhou Y.T. … Low B.C. (J. Biol. Chem. 2002) 2 3 4 23
  2. The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. (PMID: 12681488) Shen L. … Gu J. (FEBS Lett. 2003) 2 3 4 23
  3. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PMID: 12901880) Qin W. … Gu J. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  4. Differential gene expression in human hepatocellular carcinoma Hep3B cells induced by apoptosis-related gene BNIPL-2. (PMID: 15112343) Xie L. … Gu J.R. (World J. Gastroenterol. 2004) 3 23
  5. cDNA expression array analysis of gene expression in human hepatocarcinoma Hep3B cells induced by BNIPL-1. (PMID: 16143817) Xie L. … Gu J.R. (Acta Biochim. Biophys. Sin. (Shanghai) 2005) 3 23

Products for BNIPL Gene

Sources for BNIPL Gene

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