Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BNIPL Gene

protein-coding   GIFtS: 51
GCID: GC01P151009

BCL2/adenovirus E1B 19kD interacting protein like
 Explore 4 diseases affiliated with
BNIPL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BNIPL    

Aliases
for BNIPL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
BCL2/Adenovirus E1B 19kD Interacting Protein Like1 2     BNIPL12
BNIPL-21 2     BNIPL22
PP7531 2     BNIPS2
BNIPl-11     Bcl-2/Adenovirus E1B 19 KDa-Interacting Protein 2-Like Protein2
BNIP-S2     BNIP-2 Similar2
BNIPL-12     

External Ids:    HGNC: 169761   Entrez Gene: 1494282   Ensembl: ENSG000001631417   OMIM: 6112755   UniProtKB: Q7Z4653   

Export aliases for BNIPL gene to outside databases

Previous GC identifers: GC00U991195 GC01P148225 GC01P148188 GC01P147822 GC01P149275 GC01P122386


Summaries
for BNIPL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BNIPL:
The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may
function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript
variants encoding different isoforms have been described for this gene. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: BNIPL_HUMAN, Q7Z465
Function: May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death

Gene Wiki entry for BNIPL


Genomic Views
for BNIPL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BNIPL gene promoter:
         STAT1   NF-1   NF-1/L   AML1a   STAT1beta   STAT1alpha   AREB6   CP2   SEF-1 (1)   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BNIPL promoter sequence
   Search SABiosciences Chromatin IP Primers for BNIPL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BNIPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

BNIPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BNIPL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151009:  view genomic region     (about GC identifiers)

Start:
 151,009,029 bp from pter      End:
 151,020,076 bp from pter
Size:
 11,048 bases      Orientation:
 plus strand

Proteins
for BNIPL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BNIPL_HUMAN, Q7Z465 (See protein sequence)
Recommended Name: Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein  
Size: 357 amino acids; 39713 Da
Subunit: Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER
Secondary accessions: Q6DK43 Q8TCY7 Q8WYG2
Alternative splicing: 3 isoforms:  Q7Z465-1   Q7Z465-2   Q7Z465-3   

Explore the universe of human proteins at neXtProt for BNIPL: NX_Q7Z465

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z465

    • BNIPL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153114.1  NP_612122.2  

    ENSEMBL proteins: 
     ENSP00000357927   ENSP00000355333   ENSP00000295294   ENSP00000376550   ENSP00000435072  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: BNIPL
    OriGene Protein Over-expression Lysate: BNIPL
    OriGene Custom Protein Services for BNIPL 
    GenScript Custom Purified and Recombinant Proteins Services for BNIPL
    Novus Biologicals BNIPL Protein
    Novus Biologicals BNIPL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BNIPL

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11741952
    GO:0005829cytosol IDA11741952


    BNIPL for ontologies           About GeneDecksing



    BNIPL Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BNIPL
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BNIPL 
    GenScript Custom Superior Antibodies Services for BNIPL
    Novus Biologicals BNIPL Antibodies
    Search for Antibodies for BNIPL at Abcam  
    Uscn Antibodies for BNIPL
    Search ThermoFisher Antibodies for BNIPL

    Assay Products for BNIPL: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BNIPL
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BNIPL

    Protein Domains /
    Families
    for BNIPL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BNIPL for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR022181 Bcl2-/adenovirus-E1B
     IPR001251 CRAL-TRIO_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z465

    ProtoNet protein and cluster: Q7Z465

    UniProtKB/Swiss-Prot: BNIPL_HUMAN, Q7Z465
    Similarity: Contains 1 CRAL-TRIO domain


    Function
    for BNIPL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BNIPL_HUMAN, Q7Z465
    Function: May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): BNIPL
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BNIPL
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BNIPL:
    hsa-miR-513a-5p hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmid: BNIPL 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BNIPL (see all 7)
    OriGene shRNA RFP: BNIPL
    OriGene siRNA: BNIPL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BNIPL

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BNIPL

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BNIPL (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BNIPL (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): BNIPL (NM_138278)
    Sino Biological Human cDNA Clone for BNIPL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BNIPL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BNIPL 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for BNIPL
    Search LifeMap BioReagents cell lines for BNIPL

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNIPL

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12681488
    GO:0042802identical protein binding IPI12901880


    BNIPL for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for BNIPL:
     Increased TP53 protein express 


    Pathways & Interactions
    for BNIPL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BNIPL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for BNIPL (Q7Z4653 ENSP000003579274) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104153, ENSP000003296234I2D: score=3 STRING: ENSP00000329623
    GFERP557893, ENSP000002481144I2D: score=3 STRING: ENSP00000248114
    MIFP141743, ENSP000002157544I2D: score=3 STRING: ENSP00000215754
    BAXQ078123, ENSP000002932884I2D: score=1 STRING: ENSP00000293288
    ARHGAP1Q079603, ENSP000003104914I2D: score=4 STRING: ENSP00000310491
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IDA12901880
    GO:0006917induction of apoptosis IDA11741952
    GO:0008285negative regulation of cell proliferation IDA12681488
    GO:0040009regulation of growth rate IDA12681488


    BNIPL for ontologies           About GeneDecksing



    Drugs & Compounds
    for BNIPL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BNIPL
    Search CenterWatch for drugs/clinical trials and news about BNIPL 

    Transcripts
    for BNIPL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BNIPL gene (3 alternative transcripts): 
    NM_001159642.1  NM_138278.3  NM_138279.2  

    Unigene Cluster for BNIPL:

    BCL2/adenovirus E1B 19kD interacting protein like
    Hs.591473  [show with all ESTs]
    Unigene Representative Sequence: NM_001159642
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368931(uc001ewl.2 uc009wmj.2) ENST00000361277 ENST00000295294(uc009wmi.2)
    ENST00000392802 ENST00000485855 ENST00000491386

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): BNIPL
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BNIPL
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BNIPL:
    hsa-miR-513a-5p hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmid: BNIPL 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BNIPL (see all 7)
    OriGene shRNA RFP: BNIPL
    OriGene siRNA: BNIPL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BNIPL
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BNIPL (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BNIPL (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): BNIPL (NM_138278)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BNIPL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BNIPL 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BNIPL
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BNIPL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BNIPL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BNIPL

    Additional cDNA sequence: 

    AF193056.1 AK092595.1 AY033000.1 AY078983.1 BC027868.1 BC074779.2 BC074780.2 

    5 DOTS entries:

    DT.92415423  DT.97828137  DT.40113978  DT.40192205  DT.97828136 

    24/27 AceView cDNA sequences (see all 27):

    AY078984 BX641946 AY033000 BC027868 AW006452 NM_138279 AY078983 AK092595 
    BC074780 BU594613 AF193056 BC074779 CD687603 NM_138278 AX747620 BQ638028 
    CD636354 CD636351 AA719034 W69365 W69364 BX641945 AW452434 CD688478 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BNIPL (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                                                                                                        -                           
    SP2:                                                                                                  -     -                           
    SP3:                    -                 -     -                                                                                       
    SP4:                    -     -     -     -     -                                                                                       
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for BNIPL

    Expression
    for BNIPL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BNIPL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGCTGCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BNIPL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal Collecting Duct SystemKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BNIPL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BNIPL

    SOURCE GeneReport for Unigene cluster: Hs.591473

    UniProtKB/Swiss-Prot: BNIPL_HUMAN, Q7Z465
    Tissue specificity: Isoform 2 is expressed in placenta and lung

        SABiosciences Custom PCR Arrays for BNIPL
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BNIPL
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BNIPL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BNIPL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BNIPL
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNIPL

    Orthologs
    for BNIPL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for BNIPL gene from 3/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia BNIPL6
    		 --
    		 54(a)
    		 1 ↔ 1
    		 AAWZ02041417(691-5192)
    zebrafish
    (Danio rerio)    		 Actinopterygii bnipl1 BCL2/adenovirus E1B 19kD interacting protein like 55.04(n)
    46.73(a)    		   100149386  NM_001128394.1  NP_001121866.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG115936
    		 --
    		 19(a)
    		 1 → many
    		 3L(4037523-4040482)


    ENSEMBL Gene Tree for BNIPL (if available)
    TreeFam Gene Tree for BNIPL (if available) 

    Paralogs
    for BNIPL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BNIPL gene
    PRUNE22  BNIP22  ARHGAP82  ATCAY2  PRR5-ARHGAP82  ARHGAP12  
    4 SIMAP similar genes for BNIPL using alignment to 3 protein entries:     BNIPL_HUMAN (see all proteins):
    BNIP2    ATCAY    PRUNE2    ARHGAP8

    BNIPL for paralogs           About GeneDecksing



    Genomic Variants
    for BNIPL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/186 NCBI SNPs in BNIPL are shown (see all 186)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs121353831,2
    		H--122386006(+) cccggC/GcAGAA 2 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs121354091,2
    		C,--122386101(+) AATTGC/TCNNNN 2 -- us2k12Minor allele frequency- T:0.27NA 122
    rs756989461,2
    		--122386210(+) TCCTGA/GGGAGA 2 -- us2k10--------
    rs15340581,2
    		C,F,A,H,--122386879(+) NNNNTA/GACTAG 2 -- int16Minor allele frequency- G:0.37NA WA CSA 130
    rs15340591,2
    		C,F,A,H,--122386909(+) GCTCAA/GTGATA 2 -- int114Minor allele frequency- G:0.19NS EA NA WA CSA 1502
    rs117999641,2
    		C,F,A,H,--122387093(+) GAGAAG/ACATCT 2 -- ut51 int1 ese316Minor allele frequency- A:0.16NS EA NA WA CSA 1714
    rs120702881,2
    		C,F,--122387174(+) CATTTC/GAATTA 2 -- int1 ut512Minor allele frequency- G:0.16WA NA 238
    rs791383641,2
    		C,--122387908(+) TGGTGG/ATGCAC 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1112259911,2
    		--122387922(+) TGTAGG/TCCCAG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs765969571,2
    		C,--122391896(+) GAATAG/AGAAGA 2 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for BNIPL (151009029 - 151020076 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BNIPL: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BNIPL
    DNA2.0 Custom Variant and Variant Library Synthesis for BNIPL

    Disorders / Diseases
    for BNIPL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BNIPL for disorders           About GeneDecksing

    OMIM gene information: 611275    OMIM disorders: --

    4 diseases for BNIPL:    About MalaCards
    trigeminal neuralgia    hepatocellular carcinoma    kidney disease    carcinoma

    1 disease from the University of Copenhagen DISEASES database for BNIPL:
    Trigeminal neuralgia

    1 Novoseek disease relationship for BNIPL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 35 2 15112343 (1), 16143817 (1)

    Human Genome Epidemiology (HuGE) Navigator: BNIPL (1 document)

    Export disorders for BNIPL gene to outside databases

    Publications
    for BNIPL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BNIPL gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with BNIPL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. (PubMed id 12681488)1, 2, 3, 9 Shen L.... Gu J. (2003)
    2. The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence. (PubMed id 11741952)1, 2, 3, 9 Zhou Y.T....Low B.C. (2002)
    3. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PubMed id 12901880)1, 2, 9 Qin W.... Gu J. (2003)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. cDNA expression array analysis of gene expression in human hepatocarcinoma Hep3B cells induced by BNIPL-1. (PubMed id 16143817)1, 9 Xie L....Gu J.R. (2005)
    7. Differential gene expression in human hepatocellular carcinoma Hep3B cells induced by apoptosis-related gene BNIPL-2. (PubMed id 15112343)1, 9 Xie L....Gu J.R. (2004)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
    10. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (2010)

    External Searches for BNIPL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BNIPL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 149428 HGNC: 16976 AceView: BNIPL Ensembl:ENSG00000163141 euGenes: HUgn149428
    ECgene: BNIPL H-InvDB: BNIPL

    Other Databases showing BNIPL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BNIPL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BNIPL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for BNIPL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BNIPL gene:
    Search GeneIP for patents involving BNIPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for BNIPL gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of BNIPL
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for BNIPL  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BNIPL   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BNIPL  
     OriGene Protein Over-expression Lysate for BNIPL   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for BNIPL   OriGene 3'-UTR Clone for BNIPL  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BNIPL   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BNIPL  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for BNIPL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BNIPL   OriGene Custom Protein Services for BNIPL  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BNIPL
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BNIPL
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BNIPL
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BNIPL
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BNIPL
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BNIPL
     GenScript Custom Purified and Recombinant Proteins Services for BNIPL GenScript cDNA clones with any tag delivered in your preferred vector for BNIPL
     GenScript Custom Assay Services for BNIPL GenScript Custom Superior Antibodies Services for BNIPL
     GenScript Custom overexpressing Cell Line Services for BNIPL CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BNIPL promoter
     Search Chromatin IP Primers for BNIPL
     RT2 qPCR Primer Assay in human, mouse, rat BNIPL
     GNC Network for BNIPL
     SABiosciences Custom PCR Arrays for BNIPL
     Search Tocris compounds for BNIPL
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for BNIPL
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BNIPL antibodies
     BNIPL proteins
     BNIPL lysates
     Search for Antibodies for BNIPL at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for BNIPL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     BNIPL Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for BNIPL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNIPL
     SwitchGear 3'UTR luciferase reporter plasmids for BNIPL
     SwitchGear Promoter luciferase reporter plasmids for BNIPL
     Search ThermoFisher Antibodies for BNIPL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BNIPL
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      BNIPL gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4