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Aliases for BNIPL Gene

Aliases for BNIPL Gene

  • BCL2/Adenovirus E1B 19kD Interacting Protein Like 2 3 5
  • BNIP-2 Similar 3
  • BNIPL-1 3
  • BNIPL-2 3
  • BNIP-S 3
  • BNIPL1 3
  • BNIPL2 3
  • BNIPS 3
  • PP753 3

External Ids for BNIPL Gene

Previous GeneCards Identifiers for BNIPL Gene

  • GC00U991195
  • GC01P148225
  • GC01P148188
  • GC01P147822
  • GC01P149275
  • GC01P122386

Summaries for BNIPL Gene

Entrez Gene Summary for BNIPL Gene

  • The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for BNIPL Gene

BNIPL (BCL2/Adenovirus E1B 19kD Interacting Protein Like) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is PRUNE2.

UniProtKB/Swiss-Prot for BNIPL Gene

  • May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.

Gene Wiki entry for BNIPL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNIPL Gene

Genomics for BNIPL Gene

Regulatory Elements for BNIPL Gene

Enhancers for BNIPL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BNIPL on UCSC Golden Path with GeneCards custom track

Genomic Location for BNIPL Gene

151,036,553 bp from pter
151,047,600 bp from pter
11,048 bases
Plus strand

Genomic View for BNIPL Gene

Genes around BNIPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BNIPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BNIPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIPL Gene

Proteins for BNIPL Gene

  • Protein details for BNIPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6DK43
    • Q8TCY7
    • Q8WYG2

    Protein attributes for BNIPL Gene

    357 amino acids
    Molecular mass:
    39713 Da
    Quaternary structure:
    • Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER.

    Alternative splice isoforms for BNIPL Gene


neXtProt entry for BNIPL Gene

Proteomics data for BNIPL Gene at MOPED

Post-translational modifications for BNIPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BNIPL Gene

No data available for DME Specific Peptides for BNIPL Gene

Domains & Families for BNIPL Gene

Protein Domains for BNIPL Gene

Suggested Antigen Peptide Sequences for BNIPL Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CRAL-TRIO domain.
  • Contains 1 CRAL-TRIO domain.
genes like me logo Genes that share domains with BNIPL: view

No data available for Gene Families for BNIPL Gene

Function for BNIPL Gene

Molecular function for BNIPL Gene

UniProtKB/Swiss-Prot Function:
May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.
genes like me logo Genes that share phenotypes with BNIPL: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BNIPL Gene

Localization for BNIPL Gene

Subcellular locations from

Jensen Localization Image for BNIPL Gene COMPARTMENTS Subcellular localization image for BNIPL gene
Compartment Confidence
cytosol 5
nucleus 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BNIPL Gene

Pathways & Interactions for BNIPL Gene

SuperPathways for BNIPL Gene

No Data Available

Gene Ontology (GO) - Biological Process for BNIPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 11741952
GO:0008285 negative regulation of cell proliferation IDA 12681488
genes like me logo Genes that share ontologies with BNIPL: view

No data available for Pathways by source and SIGNOR curated interactions for BNIPL Gene

Drugs & Compounds for BNIPL Gene

No Compound Related Data Available

Transcripts for BNIPL Gene

Unigene Clusters for BNIPL Gene

BCL2/adenovirus E1B 19kD interacting protein like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BNIPL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - - -
SP4: - - - - -

Relevant External Links for BNIPL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BNIPL Gene

mRNA expression in normal human tissues for BNIPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BNIPL Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x12.6), Skin - Not Sun Exposed (Suprapubic) (x12.1), Esophagus - Mucosa (x11.2), and Vagina (x5.5).

Protein differential expression in normal tissues from HIPED for BNIPL Gene

This gene is overexpressed in Urine (34.0) and Cervix (29.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BNIPL Gene

SOURCE GeneReport for Unigene cluster for BNIPL Gene Hs.591473

mRNA Expression by UniProt/SwissProt for BNIPL Gene

Tissue specificity: Isoform 2 is expressed in placenta and lung.
genes like me logo Genes that share expression patterns with BNIPL: view

Protein tissue co-expression partners for BNIPL Gene

- Elite partner

Primer Products

Orthologs for BNIPL Gene

This gene was present in the common ancestor of animals.

Orthologs for BNIPL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BNIPL 35
  • 88.64 (n)
  • 88.17 (a)
  • 88 (a)
(Canis familiaris)
Mammalia BNIPL 35
  • 87.89 (n)
  • 85.88 (a)
  • 84 (a)
(Mus musculus)
Mammalia Bnipl 35
  • 84.23 (n)
  • 85.35 (a)
Bnipl 16
Bnipl 36
  • 85 (a)
(Pan troglodytes)
Mammalia BNIPL 35
  • 99.63 (n)
  • 99.44 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Bnipl 35
  • 84.32 (n)
  • 85.92 (a)
(Ornithorhynchus anatinus)
Mammalia BNIPL 36
  • 79 (a)
(Anolis carolinensis)
Reptilia BNIPL 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bnipl 35
  • 59.04 (n)
  • 52.98 (a)
(Danio rerio)
Actinopterygii bnipl 35
  • 55.62 (n)
  • 47.19 (a)
bnipl 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11593 36
  • 22 (a)
Species with no ortholog for BNIPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BNIPL Gene

Gene Tree for BNIPL (if available)
Gene Tree for BNIPL (if available)

Paralogs for BNIPL Gene

Paralogs for BNIPL Gene

(4) SIMAP similar genes for BNIPL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BNIPL: view

Variants for BNIPL Gene

Sequence variations from dbSNP and Humsavar for BNIPL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12068365 -, - 151,043,392(+) CAGAA(A/G)CAGCA nc-transcript-variant, reference, missense
rs955955 -- 151,039,067(+) TAGAG(A/G)CTAGA intron-variant
rs1534058 -- 151,037,213(+) GGCCT(A/G)ACTAG intron-variant
rs1534059 -- 151,037,243(+) GCTCA(A/G)TGATA intron-variant
rs1969442 -- 151,037,158(+) TCCAC(C/T)TATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BNIPL Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680
esv1745722 CNV Insertion 17803354

Variation tolerance for BNIPL Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.27; 76.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BNIPL Gene

Disorders for BNIPL Gene

Relevant External Links for BNIPL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BNIPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BNIPL Gene

Publications for BNIPL Gene

  1. The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. (PMID: 12681488) Shen L. … Gu J. (FEBS Lett. 2003) 2 3 4 23 67
  2. The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence. (PMID: 11741952) Zhou Y.T. … Low B.C. (J. Biol. Chem. 2002) 2 3 23
  3. cDNA expression array analysis of gene expression in human hepatocarcinoma Hep3B cells induced by BNIPL-1. (PMID: 16143817) Xie L. … Gu J.R. (Acta Biochim. Biophys. Sin. (Shanghai) 2005) 3 23
  4. Differential gene expression in human hepatocellular carcinoma Hep3B cells induced by apoptosis-related gene BNIPL-2. (PMID: 15112343) Xie L. … Gu J.R. (World J. Gastroenterol. 2004) 3 23
  5. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PMID: 12901880) Qin W. … Gu J. (Biochem. Biophys. Res. Commun. 2003) 3 23

Products for BNIPL Gene

Sources for BNIPL Gene