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Aliases for BNIPL Gene

Aliases for BNIPL Gene

  • BCL2 Interacting Protein Like 2 3 5
  • BCL2/Adenovirus E1B 19kD Interacting Protein Like 2 3
  • Bcl-2/Adenovirus E1B 19 KDa-Interacting Protein 2-Like Protein 3
  • BNIP-2 Similar 3
  • BNIP-Salpha 3
  • BNIP-Sbeta 3
  • BNIPL-1 3
  • BNIPL-2 3
  • BNIP-S 3
  • BNIPL1 3
  • BNIPL2 3
  • BNIPS 3
  • PP753 3

External Ids for BNIPL Gene

Previous GeneCards Identifiers for BNIPL Gene

  • GC00U991195
  • GC01P148225
  • GC01P148188
  • GC01P147822
  • GC01P149275
  • GC01P122386

Summaries for BNIPL Gene

Entrez Gene Summary for BNIPL Gene

  • The protein encoded by this gene interacts with several other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for BNIPL Gene

BNIPL (BCL2 Interacting Protein Like) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is BNIP2.

UniProtKB/Swiss-Prot for BNIPL Gene

  • May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.

Gene Wiki entry for BNIPL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNIPL Gene

Genomics for BNIPL Gene

Regulatory Elements for BNIPL Gene

Enhancers for BNIPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F151142 1.3 Ensembl ENCODE 32.2 +108.7 108656 6.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 BNIPL GABPB2 SEMA6C PRUNE1 TMOD4 VPS72 PIP5K1A RNU6-884P LYSMD1 C1orf56
GH01F151054 1.2 ENCODE 24.3 +22.5 22451 9.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 FEZF1 DMAP1 BNIPL SETDB1 GABPB2 PRPF3 MRPL9 CTSK UBE2D3P3 RPS10P6 PSMD4 ECM1
GH01F151068 1.2 ENCODE 23.8 +33.9 33933 3.3 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 YY1 ZNF416 ZNF143 GABPB2 MRPL9 SETDB1 PRPF3 UBE2D3P3 LYSMD1 CTSK GOLPH3L BNIPL RPS10P6
GH01F151193 1.5 FANTOM5 ENCODE 16 +161.1 161094 7.7 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 SETDB1 GOLPH3L PRPF3 GABPB2 UBE2D3P3 MRPL9 RPS10P6 SCNM1 LYSMD1 RN7SL444P
GH01F151130 0.7 ENCODE 22.2 +95.2 95212 1.8 PKNOX1 ZMYM3 BMI1 SP1 ZNF366 POLR2A EGR1 NFYB ZNF512 KDM1A BNIPL SEMA6C GABPB2 CTSS ENSG00000261168
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BNIPL on UCSC Golden Path with GeneCards custom track

Genomic Location for BNIPL Gene

Chromosome:
1
Start:
151,036,553 bp from pter
End:
151,047,600 bp from pter
Size:
11,048 bases
Orientation:
Plus strand

Genomic View for BNIPL Gene

Genes around BNIPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BNIPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BNIPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIPL Gene

Proteins for BNIPL Gene

  • Protein details for BNIPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z465-BNIPL_HUMAN
    Recommended name:
    Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
    Protein Accession:
    Q7Z465
    Secondary Accessions:
    • Q6DK43
    • Q8TCY7
    • Q8WYG2

    Protein attributes for BNIPL Gene

    Size:
    357 amino acids
    Molecular mass:
    39713 Da
    Quaternary structure:
    • Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER.

    Alternative splice isoforms for BNIPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BNIPL Gene

Post-translational modifications for BNIPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BNIPL Gene

Domains & Families for BNIPL Gene

Gene Families for BNIPL Gene

Protein Domains for BNIPL Gene

Suggested Antigen Peptide Sequences for BNIPL Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z465

UniProtKB/Swiss-Prot:

BNIPL_HUMAN :
  • Contains 1 CRAL-TRIO domain.
Domain:
  • Contains 1 CRAL-TRIO domain.
genes like me logo Genes that share domains with BNIPL: view

Function for BNIPL Gene

Molecular function for BNIPL Gene

UniProtKB/Swiss-Prot Function:
May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.

Gene Ontology (GO) - Molecular Function for BNIPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12681488
GO:0042802 identical protein binding IPI 12901880
genes like me logo Genes that share ontologies with BNIPL: view
genes like me logo Genes that share phenotypes with BNIPL: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BNIPL Gene

Localization for BNIPL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BNIPL gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for BNIPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11741952
GO:0005829 cytosol IDA 11741952
genes like me logo Genes that share ontologies with BNIPL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BNIPL Gene

Pathways & Interactions for BNIPL Gene

SuperPathways for BNIPL Gene

No Data Available

Gene Ontology (GO) - Biological Process for BNIPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 11741952
GO:0008285 negative regulation of cell proliferation IDA 12681488
GO:0040009 regulation of growth rate IDA 12681488
genes like me logo Genes that share ontologies with BNIPL: view

No data available for Pathways by source and SIGNOR curated interactions for BNIPL Gene

Transcripts for BNIPL Gene

Unigene Clusters for BNIPL Gene

BCL2/adenovirus E1B 19kD interacting protein like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BNIPL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for BNIPL Gene

GeneLoc Exon Structure for
BNIPL
ECgene alternative splicing isoforms for
BNIPL

Expression for BNIPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BNIPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BNIPL Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x12.6), Skin - Not Sun Exposed (Suprapubic) (x12.1), Esophagus - Mucosa (x11.2), and Vagina (x5.5).

Protein differential expression in normal tissues from HIPED for BNIPL Gene

This gene is overexpressed in Urine (34.0) and Cervix (29.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BNIPL Gene



Protein tissue co-expression partners for BNIPL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BNIPL Gene:

BNIPL

SOURCE GeneReport for Unigene cluster for BNIPL Gene:

Hs.591473

mRNA Expression by UniProt/SwissProt for BNIPL Gene:

Q7Z465-BNIPL_HUMAN
Tissue specificity: Isoform 2 is expressed in placenta and lung.
genes like me logo Genes that share expression patterns with BNIPL: view

Primer Products

Orthologs for BNIPL Gene

This gene was present in the common ancestor of animals.

Orthologs for BNIPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BNIPL 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia BNIPL 34 35
  • 88.64 (n)
dog
(Canis familiaris)
Mammalia BNIPL 34 35
  • 87.89 (n)
rat
(Rattus norvegicus)
Mammalia Bnipl 34
  • 84.32 (n)
mouse
(Mus musculus)
Mammalia Bnipl 34 16 35
  • 84.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BNIPL 35
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BNIPL 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bnipl 34
  • 59.04 (n)
zebrafish
(Danio rerio)
Actinopterygii bnipl 34 35
  • 55.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11593 35
  • 22 (a)
OneToMany
Species where no ortholog for BNIPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BNIPL Gene

ENSEMBL:
Gene Tree for BNIPL (if available)
TreeFam:
Gene Tree for BNIPL (if available)

Paralogs for BNIPL Gene

Paralogs for BNIPL Gene

(4) SIMAP similar genes for BNIPL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BNIPL: view

Variants for BNIPL Gene

Sequence variations from dbSNP and Humsavar for BNIPL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1048366 -- 151,047,572(+) AACTG(A/C)GATGA upstream-variant-2KB, utr-variant-3-prime
rs10674439 -- 151,045,579(+) AAAAA(-/AA)TCTTG intron-variant
rs10888401 -- 151,036,215(+) TTTTG(G/T)ATTTT upstream-variant-2KB
rs111225991 -- 151,038,255(+) TGTAG(G/T)CCCAG intron-variant
rs111442223 -- 151,042,614(+) TTCAA(A/G)ACCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BNIPL Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV gain 19592680
nsv1145369 CNV deletion 24896259
esv1745722 CNV insertion 17803354

Variation tolerance for BNIPL Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.27; 76.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BNIPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BNIPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BNIPL Gene

Disorders for BNIPL Gene

Relevant External Links for BNIPL

Genetic Association Database (GAD)
BNIPL
Human Genome Epidemiology (HuGE) Navigator
BNIPL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BNIPL

No disorders were found for BNIPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BNIPL Gene

Publications for BNIPL Gene

  1. The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. (PMID: 12681488) Shen L. … Gu J. (FEBS Lett. 2003) 2 3 4 22 64
  2. The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence. (PMID: 11741952) Zhou Y.T. … Low B.C. (J. Biol. Chem. 2002) 2 3 4 22 64
  3. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. (PMID: 12901880) Qin W. … Gu J. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for BNIPL Gene

Sources for BNIPL Gene

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