Aliases for BNIP3L Gene
External Ids for BNIP3L Gene
Previous GeneCards Identifiers for BNIP3L Gene
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
GeneCards Summary for BNIP3L Gene
BNIP3L (BCL2 Interacting Protein 3 Like) is a Protein Coding gene. Diseases associated with BNIP3L include Glossopharyngeal Neuralgia and Glossopharyngeal Nerve Disease. Among its related pathways are Apoptosis and Autophagy and Mitophagy - animal. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BNIP3.
UniProtKB/Swiss-Prot for BNIP3L Gene
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.