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Aliases for BNIP3L Gene

Aliases for BNIP3L Gene

  • BCL2/Adenovirus E1B 19kDa Interacting Protein 3-Like 2 3
  • NIX 3 4 6
  • BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 3A 3 4
  • NIP3-Like Protein X 3 4
  • BNIP3a 3 4
  • NIP3L 3 4
  • BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 3-Like 3
  • BCL2/Adenovirus E1B 19-Kd Protein-Interacting Protein 3a 3
  • BCL2/Adenovirus E1B 19kD-Interacting Protein 3-Like 2
  • Adenovirus E1B19k-Binding Protein B5 3
  • Adenovirus E1B19K-Binding Protein B5 4
  • BNIP3H 4

External Ids for BNIP3L Gene

Summaries for BNIP3L Gene

Entrez Gene Summary for BNIP3L Gene

  • This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]

GeneCards Summary for BNIP3L Gene

BNIP3L (BCL2/Adenovirus E1B 19kDa Interacting Protein 3-Like) is a Protein Coding gene. Diseases associated with BNIP3L include visual epilepsy. Among its related pathways are Direct p53 effectors and Apoptosis (WikiPathways). GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BNIP3.

UniProtKB/Swiss-Prot for BNIP3L Gene

  • Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.

Gene Wiki entry for BNIP3L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNIP3L Gene

Genomics for BNIP3L Gene

Genomic Location for BNIP3L Gene

Start:
26,382,898 bp from pter
End:
26,505,636 bp from pter
Size:
122,739 bases
Orientation:
Plus strand

Genomic View for BNIP3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BNIP3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIP3L Gene

Regulatory Elements for BNIP3L Gene

Proteins for BNIP3L Gene

  • Protein details for BNIP3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60238-BNI3L_HUMAN
    Recommended name:
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
    Protein Accession:
    O60238
    Secondary Accessions:
    • B0AZS9
    • Q5JW63
    • Q8NF87

    Protein attributes for BNIP3L Gene

    Size:
    219 amino acids
    Molecular mass:
    23930 Da
    Quaternary structure:
    • Self-associates. Interacts with BNIP3 and STEAP3. Interacts with human adenovirus-2 E1B 19 kDa protein. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains).
    SequenceCaution:
    • Sequence=CAI46217.1; Type=Erroneous termination; Positions=122; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for BNIP3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BNIP3L Gene

Proteomics data for BNIP3L Gene at MOPED

Post-translational modifications for BNIP3L Gene

  • Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys154 and Lys177

Other Protein References for BNIP3L Gene

No data available for DME Specific Peptides for BNIP3L Gene

Domains for BNIP3L Gene

Protein Domains for BNIP3L Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

BNI3L_HUMAN
Family:
  • Belongs to the NIP3 family.:
    • O60238
genes like me logo Genes that share domains with BNIP3L: view

No data available for Gene Families for BNIP3L Gene

Function for BNIP3L Gene

Molecular function for BNIP3L Gene

GENATLAS Biochemistry: BCL2/adenovirus E1B,interacting 3-like,proapoptotic,inhibiting growth of cancer cells,widely expressed (see TSG8A) and expressed in target of the mitochondria,when inducing apoptosis
UniProtKB/Swiss-Prot Function: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.

Gene Ontology (GO) - Molecular Function for BNIP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10381623
GO:0005521 lamin binding IPI 10381623
GO:0042802 identical protein binding IPI 10381623
GO:0042803 protein homodimerization activity IDA 10381623
GO:0046982 protein heterodimerization activity IDA 10381623
genes like me logo Genes that share ontologies with BNIP3L: view
genes like me logo Genes that share phenotypes with BNIP3L: view

Animal Models for BNIP3L Gene

MGI Knock Outs for BNIP3L:

miRNA for BNIP3L Gene

miRTarBase miRNAs that target BNIP3L

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BNIP3L Gene

Localization for BNIP3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for BNIP3L Gene

Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane; Single-pass membrane protein. Note=Colocalizes with SPATA18 at the mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BNIP3L Gene COMPARTMENTS Subcellular localization image for BNIP3L gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytosol 3
extracellular 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BNIP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA 10381623
GO:0005739 mitochondrion IDA 10381623
GO:0005740 mitochondrial envelope --
GO:0005741 mitochondrial outer membrane IMP 21264228
GO:0005783 endoplasmic reticulum IDA 10381623
genes like me logo Genes that share ontologies with BNIP3L: view

Pathways for BNIP3L Gene

genes like me logo Genes that share pathways with BNIP3L: view

Pathways by source for BNIP3L Gene

1 Cell Signaling Technology pathway for BNIP3L Gene
2 BioSystems pathways for BNIP3L Gene

Gene Ontology (GO) - Biological Process for BNIP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0035694 mitochondrial protein catabolic process IMP 21264228
GO:0043065 positive regulation of apoptotic process IDA 9973195
GO:0043066 negative regulation of apoptotic process IDA 10381623
GO:0051607 defense response to virus IDA 9973195
genes like me logo Genes that share ontologies with BNIP3L: view

Transcripts for BNIP3L Gene

Unigene Clusters for BNIP3L Gene

BCL2/adenovirus E1B 19kDa interacting protein 3-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BNIP3L Gene

No ASD Table

Relevant External Links for BNIP3L Gene

GeneLoc Exon Structure for
BNIP3L
ECgene alternative splicing isoforms for
BNIP3L

Expression for BNIP3L Gene

mRNA expression in normal human tissues for BNIP3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BNIP3L Gene

SOURCE GeneReport for Unigene cluster for BNIP3L Gene Hs.131226

genes like me logo Genes that share expressions with BNIP3L: view

Orthologs for BNIP3L Gene

This gene was present in the common ancestor of chordates.

Orthologs for BNIP3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BNIP3L 36
  • 99.85 (n)
  • 100 (a)
BNIP3L 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BNIP3L 36
  • 91.78 (n)
  • 96.8 (a)
BNIP3L 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 91 (a)
OneToMany
-- 37
  • 96 (a)
OneToMany
-- 37
  • 92 (a)
OneToMany
BNIP3L 36
  • 94.05 (n)
  • 97.3 (a)
mouse
(Mus musculus)
Mammalia Bnip3l 36
  • 91.09 (n)
  • 97.7 (a)
Bnip3l 16
Bnip3l 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BNIP3L 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BNIP3L 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bnip3l 36
  • 90.32 (n)
  • 97.7 (a)
chicken
(Gallus gallus)
Aves BNIP3L 36
  • 81.48 (n)
  • 86.24 (a)
BNIP3L 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BNIP3L 37
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19770 36
tropical clawed frog
(Silurana tropicalis)
Amphibia bnip3l 36
  • 77.36 (n)
  • 82.89 (a)
Str.1479 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1851 36
zebrafish
(Danio rerio)
Actinopterygii bnip3la 36
  • 68.99 (n)
  • 74.05 (a)
bnip3la 37
  • 58 (a)
OneToMany
bnip3lb 37
  • 60 (a)
OneToMany
wufb52b03 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3722 37
  • 25 (a)
OneToMany
Species with no ortholog for BNIP3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BNIP3L Gene

ENSEMBL:
Gene Tree for BNIP3L (if available)
TreeFam:
Gene Tree for BNIP3L (if available)

Paralogs for BNIP3L Gene

Paralogs for BNIP3L Gene

Selected SIMAP similar genes for BNIP3L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with BNIP3L: view

Variants for BNIP3L Gene

Sequence variations from dbSNP and Humsavar for BNIP3L Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs12165 -- 26,411,896(+) GTGCA(C/T)CAGGT utr-variant-3-prime
rs14994 -- 26,408,311(+) TTCTC(C/T)GCAGA reference, synonymous-codon
rs1042992 -- 26,411,675(+) TTGTT(C/T)GTTCA utr-variant-3-prime
rs1055775 -- 26,410,924(+) gaaaa(A/C)aaaac utr-variant-3-prime
rs1055780 -- 26,410,929(+) CAAAA(A/C)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BNIP3L Gene

Variant ID Type Subtype PubMed ID
nsv831273 CNV Loss 17160897
nsv824580 CNV Gain 20364138

Relevant External Links for BNIP3L Gene

HapMap Linkage Disequilibrium report
BNIP3L

Disorders for BNIP3L Gene

(1) MalaCards Diseases for BNIP3L Gene

Search for BNIP3L Gene in MalaCards »

(1) University of Copenhagen DISEASES for BNIP3L Gene

(3) Novoseek inferred disease relationships for BNIP3L Gene

Disease -log(P) Hits PubMed IDs
cancer 27.9 6
tumors 18.3 7
cancer lung 4.53 11

Relevant External Links for BNIP3L

Genetic Association Database (GAD)
BNIP3L
Human Genome Epidemiology (HuGE) Navigator
BNIP3L
genes like me logo Genes that share disorders with BNIP3L: view

No data available for UniProtKB/Swiss-Prot for BNIP3L Gene

Publications for BNIP3L Gene

  1. Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3. (PMID: 9523198) Matsushima M. … Nakamura Y. (Genes Chromosomes Cancer 1998) 2 3 4 23
  2. Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. (PMID: 9867803) Chen G. … Greenberg A. (J. Biol. Chem. 1999) 3 4 23
  3. The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. (PMID: 12663450) Aerbajinai W. … Miller J.L. (Blood 2003) 3 4 23
  4. Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. (PMID: 18551130) Papandreou I. … Denko N.C. (Cell Death Differ. 2008) 3 23
  5. Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. (PMID: 16219518) Stepan H. … Horn L.C. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2005) 3 23

Products for BNIP3L Gene

Sources for BNIP3L Gene

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