Aliases for BNIP3 Gene
External Ids for BNIP3 Gene
Previous GeneCards Identifiers for BNIP3 Gene
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]
GeneCards Summary for BNIP3 Gene
BNIP3 (BCL2/Adenovirus E1B 19kDa Interacting Protein 3) is a Protein Coding gene. Diseases associated with BNIP3 include leiomyomatosis and renal cell cancer and colorectal cancer. Among its related pathways are HIF-1-alpha transcription factor network and FoxO signaling pathway. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BNIP3L.
UniProtKB/Swiss-Prot for BNIP3 Gene
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.