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BNIP3 Gene

protein-coding   GIFtS: 62
GCID: GC10M133781

BCL2/Adenovirus E1B 19kDa Interacting Protein 3

(Previous name: BCL2/adenovirus E1B 19kD-interacting protein 3)
  See BNIP3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BCL2/Adenovirus E1B 19kDa Interacting Protein 31 2
NIP32 3 5
BCL2/Adenovirus E1B 19kD-Interacting Protein 31
BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 32

External Ids:    HGNC: 10841   Entrez Gene: 6642   Ensembl: ENSG000001761717   OMIM: 6032935   UniProtKB: Q129833   

Export aliases for BNIP3 gene to outside databases

Previous GC identifers: GC14U990005 GC14P026723 GC10M133215 GC10M133631 GC10M127330


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BNIP3 Gene:
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the
E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with
E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a
transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein
encoded by this gene is known to induce apoptosis, even in the presence of BCL2. (provided by RefSeq, Mar 2011)

GeneCards Summary for BNIP3 Gene:
BNIP3 (BCL2/adenovirus E1B 19kDa interacting protein 3) is a protein-coding gene. Diseases associated with BNIP3 include hereditary leiomyomatosis and renal cell cancer, and malignant glioma. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is BNIP3L.

UniProtKB/Swiss-Prot: BNIP3_HUMAN, Q12983
Function: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium
between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality
control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to
mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside
mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane
regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of
lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin
(S100A8/A9)-induced cell death pathway

Gene Wiki entry for BNIP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the BNIP3 gene promoter:
         GR   AML1a   p53   HNF-1   GR-beta   ATF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BNIP3 promoter sequence
   Search Chromatin IP Primers for BNIP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BNIP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

BNIP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BNIP3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M133781:  view genomic region     (about GC identifiers)

Start:
133,781,204 bp from pter      End:
133,795,435 bp from pter
Size:
14,232 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BNIP3_HUMAN, Q12983 (See protein sequence)
Recommended Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3  
Size: 194 amino acids; 21541 Da
Subunit: Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa
protein or Epstein-Barr virus BHRF1. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains)
3 PDB 3D structures from and Proteopedia for BNIP3:
2J5D (3D)        2KA1 (3D)        2KA2 (3D)    
Secondary accessions: O14620 Q96GP0

Explore the universe of human proteins at neXtProt for BNIP3: NX_Q12983

Explore proteomics data for BNIP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys153
  • Modification sites at PhosphoSitePlus

  • See BNIP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004043.2  
    ENSEMBL proteins: 
     ENSP00000357625   ENSP00000446145  

    BNIP3 Human Recombinant Protein Products:

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    antibodies-online proteins for BNIP3 (4 products) 

     
    antibodies-online peptides for BNIP3

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    antibodies-online kits for BNIP3 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR010548 BNIP3

    Graphical View of Domain Structure for InterPro Entry Q12983

    ProtoNet protein and cluster: Q12983

    1 Blocks protein domain: IPB010548 BNIP3

    UniProtKB/Swiss-Prot: BNIP3_HUMAN, Q12983
    Similarity: Belongs to the NIP3 family


    Find genes that share domains with BNIP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BNIP3_HUMAN, Q12983
    Function: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium
    between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality
    control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to
    mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside
    mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane
    regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of
    lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin
    (S100A8/A9)-induced cell death pathway

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10381623
    GO:0042802identical protein binding IPI10381623
    GO:0042803protein homodimerization activity IDA10381623
    GO:0046982protein heterodimerization activity IDA10381623
    GO:0051020GTPase binding IPI--
         
    Find genes that share ontologies with BNIP3           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bnip3):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  muscle 

    Find genes that share phenotypes with BNIP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bnip3tm1Gwd for BNIP3

       genOway: Develop your customized and physiologically relevant rodent model for BNIP3

    miRNA
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    miRTarBase miRNAs that target BNIP3:
    hsa-mir-145-5p (MIRT000305), hsa-mir-221-3p (MIRT004753)

    Block miRNA regulation of human, mouse, rat BNIP3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate BNIP3:
    hsa-miR-142-5p hsa-miR-26a-2* hsa-miR-4310 hsa-miR-944 hsa-miR-26a-1*
    SwitchGear 3'UTR luciferase reporter plasmidBNIP3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat BNIP3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BNIP3_HUMAN, Q12983: Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression
    with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes
    with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol3
    lysosome2
    vacuole2
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005635nuclear envelope IDA7954800
    GO:0005654nucleoplasm ISS--
    GO:0005737cytoplasm ISS--
    GO:0005739mitochondrion TAS9973195

    Find genes that share ontologies with BNIP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BNIP3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis (WikiPathways)
    Apoptosis Modulation and Signaling0.38
    2mTOR signaling pathway
    mTOR signaling pathway
    3Legionellosis
    Legionellosis
    4HIF-1-alpha transcription factor network
    HIF-1-alpha transcription factor network
    5FoxO signaling pathway
    FoxO signaling pathway


    Find genes that share SuperPaths with BNIP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for BNIP3
        Apoptosis Modulation and Signaling
    mTOR signaling pathway
    HIF-1-alpha transcription factor network


    1 PharmGKB Pathway for BNIP3
        Busulfan Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for BNIP3):
        FoxO signaling pathway
    Legionellosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BNIP3 (see all 7): 
              Mitochondria in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BNIP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for BNIP3 (Q129831, 2, 3 ENSP000003576254) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OPA1O603131, 2, 3, ENSP000003546814EBI-749464,EBI-1054131 MINT-7906796 MINT-7906842 MINT-7906858 MINT-7906831 MINT-7906869 MINT-7906910 MINT-7906811 MINT-7906883 I2D: score=1 STRING: ENSP00000354681
    BNIP3Q129831, 2EBI-749464,EBI-749464 MINT-68406
    BNIP3LO602381, 2, 3, ENSP000003700034EBI-749464,EBI-849893 MINT-67721 I2D: score=7 STRING: ENSP00000370003
    TMEM11P171521, 2, 3, ENSP000003199924EBI-749464,EBI-723946 MINT-67537 I2D: score=6 STRING: ENSP00000319992
    BCL2P104153, ENSP000003296234I2D: score=4 STRING: ENSP00000329623
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia ISS--
    GO:0006309apoptotic DNA fragmentation ----
    GO:0006338chromatin remodeling ----
    GO:0006915apoptotic process IPI7954800
    GO:0008219cell death ISS--

    Find genes that share ontologies with BNIP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BNIP3

    1 HMDB Compound for BNIP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for BNIP3 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 65.4 5 15756280 (1), 15289340 (1), 15709167 (1), 18172295 (1)
    vegf 38.9 12 16827797 (2), 15586379 (1), 17000671 (1), 18283716 (1) (see all 11)
    oxygen 36 3 18281291 (1), 19136941 (1)
    gemcitabine 30.8 18 17729412 (6), 15837765 (3), 15856026 (1)
    mptp 19.1 5 15299040 (2), 15623420 (2)
    sb 203580 18.8 1 16954213 (1)
    5fluorouracil 13.6 7 20368736 (5), 15067352 (1), 15856026 (1)
    ceramide 10.9 7 15205343 (3), 16740734 (1)
    glucose 9.47 4 15289340 (1), 20181925 (1), 16827797 (1), 19505343 (1)
    paclitaxel 7.42 2 14985451 (1), 20100468 (1)



    Find genes that share compounds with BNIP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BNIP3 gene: 
    NM_004052.2  

    Unigene Cluster for BNIP3:

    BCL2/adenovirus E1B 19kDa interacting protein 3
    Hs.144873  [show with all ESTs]
    Unigene Representative Sequence: BX647339
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368636(uc001lkv.1) ENST00000540159(uc010qut.1)
    miRNA
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    hsa-miR-142-5p hsa-miR-26a-2* hsa-miR-4310 hsa-miR-944 hsa-miR-26a-1*
    SwitchGear 3'UTR luciferase reporter plasmidBNIP3 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat BNIP3

    Additional mRNA sequence: 

    AF002697.1 AK125699.1 AK130264.1 AK295136.1 BC009342.2 BC021989.1 BC080643.1 BX647339.1 

    12 DOTS entries:

    DT.100646177  DT.448121  DT.100773120  DT.121243576  DT.95128656  DT.95290735  DT.121243567  DT.100037079 
    DT.219406  DT.100658520  DT.435428  DT.99944702 

    Selected AceView cDNA sequences (see all 387):

    BM314407 AI360564 BX402244 AA134022 AW291438 BM460721 AA291229 AA305343 
    BM663513 AA960949 BM314327 AK125699 AI583704 R62620 BM709772 BX388671 
    BQ773585 BM720429 BC009342 CA444817 AA063521 AA983973 AA912330 BU902717 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BNIP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTGTGTTG
    BNIP3 Expression
    About this image


    BNIP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    BNIP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BNIP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.144873
        Pathway & Disease-focused RT2 Profiler PCR Arrays including BNIP3 (see all 7): 
              Mitochondria in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Oxidative Stress in human mouse rat
              Autophagy in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNIP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for BNIP3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bnip31 , 5 BCL2/adenovirus E1B interacting protein 31, 5 90.02(n)1
    94.12(a)1
      7 (82.95 cM)5
    121761  NM_009760.41  NP_033890.11 
     1388908365 
    chicken
    (Gallus gallus)
    Aves BNIP31 BCL2/adenovirus E1B 19kDa interacting protein 3 78.08(n)
    84.24(a)
      423971  XM_421829.4  XP_421829.3 
    lizard
    (Anolis carolinensis)
    Reptilia BNIP36
    BCL2/adenovirus E1B 19kDa interacting protein 3
    74(a)
    1 ↔ 1
    3(57826045-57832670)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685742 hypothetical protein MGC68574 78.41(n)    BC060010.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bnip31 BCL2/adenovirus E1B interacting protein 3 69.43(n)
    75.74(a)
      336116  NM_001012245.1  NP_001012245.1 


    ENSEMBL Gene Tree for BNIP3 (if available)
    TreeFam Gene Tree for BNIP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BNIP3 gene
    BNIP3L2  
    1 SIMAP similar gene for BNIP3 using alignment to 4 protein entries:     BNIP3_HUMAN (see all proteins):
    BNIP3L

    Find genes that share paralogs with BNIP3           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for BNIP3 (see all 52)
    PGOHUM00000258758 PGOHUM00000258788 PGOHUM00000262250 PGOHUM00000234888 PGOHUM00000234203


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BNIP3 (see all 390)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1491930321,2
    C--127329903(+) TGGCT-/TTGTTGTG 1 -- ds50010--------
    rs455432351,2
    C,F--127330022(-) ATTCCG/ATTTTT 1 -- ds50016Minor allele frequency- A:0.01NS WA 302
    rs456194391,2
    C,F--127330023(-) AATTCC/TGTTTT 1 -- ds50015Minor allele frequency- T:0.01NS 184
    rs1864698051,2
    --127330032(+) TTCCCC/TTGACC 1 -- ds50010--------
    rs1441771381,2
    --127330057(+) ATCTCA/GGACTA 1 -- ds50010--------
    rs1501335581,2
    C--127330128(+) AAGAC-/TGAGAGA 1 -- ds50010--------
    rs1932745821,2
    --127330145(+) GCTTCC/TAAGGT 1 -- ds50010--------
    rs787823211,2
    F--127330197(+) ACACCC/TGAATT 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1386506471,2
    --127330206(+) TTAAGC/TGTGGA 1 -- ds50010--------
    rs455016971,2
    C,F--127330307(-) GATAGC/GTTCTT 1 -- ds50018Minor allele frequency- G:0.03NS NA WA 294

    HapMap Linkage Disequilibrium report for BNIP3 (133781204 - 133795435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BNIP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv896117CNV Loss21882294
    nsv825650CNV Gain20364138
    nsv825651CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BNIP3
    DNA2.0 Custom Variant and Variant Library Synthesis for BNIP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603293    OMIM disorders: --

    3 diseases for BNIP3:    
    About MalaCards
    hereditary leiomyomatosis and renal cell cancer    malignant glioma    pancreatic cancer

    1 disease from the University of Copenhagen DISEASES database for BNIP3:
    Cancer

    Find genes that share disorders with BNIP3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BNIP3 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acidosis 44.4 8 15623420 (2), 12226479 (2), 15299040 (1), 17786027 (1) (see all 6)
    tumors 41.8 60 18163427 (3), 16217754 (3), 17255267 (3), 20332243 (2) (see all 27)
    cancer 40.5 20 18092960 (2), 19956881 (2), 16511341 (2), 16799636 (1) (see all 14)
    pancreatic cancer 39.5 39 17729412 (7), 15289340 (7), 15856026 (6), 15837765 (4) (see all 7)
    solid tumor 38.9 6 16511341 (1), 16217754 (1), 19339613 (1)
    malignant glioma 34.8 7 15592527 (3), 15205343 (2), 16217754 (1), 19339613 (1)
    colorectal cancer 23.4 3 19956881 (2), 16799636 (1)
    necrosis 22.5 12 14648660 (1), 17763440 (1), 18092960 (1), 15623420 (1) (see all 10)
    adenocarcinoma 19.3 3 15289340 (2), 18728663 (1)
    ischemia 9.52 6 15623420 (1), 16511341 (1), 19136941 (1), 19737385 (1)

    Genetic Association Database (GAD): BNIP3
    Human Genome Epidemiology (HuGE) Navigator: BNIP3 (2 documents)

    Export disorders for BNIP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BNIP3 gene, integrated from 10 sources (see all 195):
    (articles sorted by number of sources associating them with BNIP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. (PubMed id 7954800)1, 2, 3 Boyd J.M.... Chinnadurai G. (Cell 1994)
    2. Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines. (PubMed id 18371312)1, 2, 9 Cao W.... Lu H. (Biochim. Biophys. Acta 2008)
    3. BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria. (PubMed id 22292033)1, 2 Nakamura Y.... Arakawa H. (PLoS ONE 2012)
    4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (amp 2010)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. (PubMed id 10381623)1, 2 Ohi N.... Nakajima T. (Cell Death Differ. 1999)
    9. The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. (PubMed id 9396766)1, 2 Chen G.... Greenberg A.H. (J. Exp. Med. 1997)
    10. Mutational and expressional analysis of BNIP3, a pro-apoptotic Bcl-2 member, in gastric carcinomas. (PubMed id 18092960)1, 9 Lee S.H....Lee S.H. (APMIS 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 664 HGNC: 1084 AceView: BNIP3 Ensembl:ENSG00000176171 euGenes: HUgn664
    ECgene: BNIP3 Kegg: 664 H-InvDB: BNIP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BNIP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BNIP3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/bnip3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BNIP3 gene:
    Search GeneIP for patents involving BNIP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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