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Aliases for BNIP3 Gene

Aliases for BNIP3 Gene

  • BCL2/Adenovirus E1B 19kDa Interacting Protein 3 2 3
  • NIP3 3 4 6
  • BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 3 3
  • BCL2/Adenovirus E1B 19kD-Interacting Protein 3 2

External Ids for BNIP3 Gene

Previous GeneCards Identifiers for BNIP3 Gene

  • GC14U990005
  • GC14P026723
  • GC10M133215
  • GC10M133631
  • GC10M133781
  • GC10M127330

Summaries for BNIP3 Gene

Entrez Gene Summary for BNIP3 Gene

  • This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]

GeneCards Summary for BNIP3 Gene

BNIP3 (BCL2/Adenovirus E1B 19kDa Interacting Protein 3) is a Protein Coding gene. Diseases associated with BNIP3 include leiomyomatosis and renal cell cancer and malignant glioma. Among its related pathways are HIF-1-alpha transcription factor network and FoxO signaling pathway. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BNIP3L.

UniProtKB/Swiss-Prot for BNIP3 Gene

  • Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

Gene Wiki entry for BNIP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNIP3 Gene

Genomics for BNIP3 Gene

Regulatory Elements for BNIP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BNIP3 Gene

Start:
131,966,455 bp from pter
End:
131,981,931 bp from pter
Size:
15,477 bases
Orientation:
Minus strand

Genomic View for BNIP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BNIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIP3 Gene

Proteins for BNIP3 Gene

  • Protein details for BNIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12983-BNIP3_HUMAN
    Recommended name:
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
    Protein Accession:
    Q12983
    Secondary Accessions:
    • O14620
    • Q96GP0

    Protein attributes for BNIP3 Gene

    Size:
    194 amino acids
    Molecular mass:
    21541 Da
    Quaternary structure:
    • Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains).

    Three dimensional structures from OCA and Proteopedia for BNIP3 Gene

neXtProt entry for BNIP3 Gene

Proteomics data for BNIP3 Gene at MOPED

Post-translational modifications for BNIP3 Gene

  • Ubiquitination at Lys153
  • Modification sites at PhosphoSitePlus

Other Protein References for BNIP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BNIP3 Gene

Domains for BNIP3 Gene

Protein Domains for BNIP3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q12983

UniProtKB/Swiss-Prot:

BNIP3_HUMAN :
  • Q12983
Family:
  • Belongs to the NIP3 family.
genes like me logo Genes that share domains with BNIP3: view

No data available for Gene Families for BNIP3 Gene

Function for BNIP3 Gene

Molecular function for BNIP3 Gene

UniProtKB/Swiss-Prot Function: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

Gene Ontology (GO) - Molecular Function for BNIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10381623
GO:0042802 identical protein binding IPI 10381623
GO:0042803 protein homodimerization activity NAS 22505714
GO:0046982 protein heterodimerization activity IDA 10381623
GO:0051020 GTPase binding IPI 20436456
genes like me logo Genes that share ontologies with BNIP3: view
genes like me logo Genes that share phenotypes with BNIP3: view

Animal Models for BNIP3 Gene

MGI Knock Outs for BNIP3:

Animal Model Products

CRISPR Products

miRNA for BNIP3 Gene

miRTarBase miRNAs that target BNIP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BNIP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BNIP3 Gene

Localization for BNIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BNIP3 Gene

Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BNIP3 Gene COMPARTMENTS Subcellular localization image for BNIP3 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
lysosome 2
vacuole 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BNIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005635 nuclear envelope IDA 7954800
GO:0005654 nucleoplasm ISS --
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion TAS 9973195
genes like me logo Genes that share ontologies with BNIP3: view

Pathways for BNIP3 Gene

genes like me logo Genes that share pathways with BNIP3: view

Pathways by source for BNIP3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis in human,mouse,rat
    • Apoptosis 384HT in human,mouse,rat
    • Autophagy in human,mouse,rat
    • Hypoxia Signaling Pathway in human,mouse,rat
    • Mitochondria in human,mouse,rat

Gene Ontology (GO) - Biological Process for BNIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 mitochondrion degradation NAS 22505714
GO:0001666 response to hypoxia ISS --
GO:0006915 apoptotic process IPI 7954800
GO:0008219 cell death ISS --
GO:0008626 granzyme-mediated apoptotic signaling pathway IDA 9396766
genes like me logo Genes that share ontologies with BNIP3: view

Compounds for BNIP3 Gene

(1) HMDB Compounds for BNIP3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(16) Novoseek inferred chemical compound relationships for BNIP3 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 65.4 4
vegf 38.9 12
oxygen 36 2
gemcitabine 30.8 10
mptp 19.1 4
genes like me logo Genes that share compounds with BNIP3: view

Transcripts for BNIP3 Gene

mRNA/cDNA for BNIP3 Gene

Unigene Clusters for BNIP3 Gene

BCL2/adenovirus E1B 19kDa interacting protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BNIP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BNIP3 Gene

No ASD Table

Relevant External Links for BNIP3 Gene

GeneLoc Exon Structure for
BNIP3
ECgene alternative splicing isoforms for
BNIP3

Expression for BNIP3 Gene

mRNA expression in normal human tissues for BNIP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BNIP3 Gene

This gene is overexpressed in Pancreas (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BNIP3 Gene

SOURCE GeneReport for Unigene cluster for BNIP3 Gene Hs.144873

genes like me logo Genes that share expressions with BNIP3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for BNIP3 Gene

Orthologs for BNIP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BNIP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BNIP3 35
  • 98.8 (n)
  • 100 (a)
BNIP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BNIP3 35
  • 83.33 (n)
  • 92.27 (a)
BNIP3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BNIP3 36
  • 94 (a)
OneToOne
LOC607408 35
  • 87.29 (n)
  • 93.81 (a)
mouse
(Mus musculus)
Mammalia Bnip3 35
  • 90.02 (n)
  • 94.12 (a)
Bnip3 16
Bnip3 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BNIP3 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BNIP3 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bnip3 35
  • 90.2 (n)
  • 94.12 (a)
chicken
(Gallus gallus)
Aves BNIP3 35
  • 78.08 (n)
  • 84.24 (a)
BNIP3 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BNIP3 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68574 35
tropical clawed frog
(Silurana tropicalis)
Amphibia bnip3 35
  • 74.27 (n)
  • 81.35 (a)
Str.2462 35
zebrafish
(Danio rerio)
Actinopterygii bnip3 35
  • 69.43 (n)
  • 75.74 (a)
bnip3 36
  • 65 (a)
OneToMany
bnip4 36
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3722 36
  • 26 (a)
OneToMany
Species with no ortholog for BNIP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BNIP3 Gene

ENSEMBL:
Gene Tree for BNIP3 (if available)
TreeFam:
Gene Tree for BNIP3 (if available)

Paralogs for BNIP3 Gene

Paralogs for BNIP3 Gene

Selected SIMAP similar genes for BNIP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BNIP3: view

Variants for BNIP3 Gene

Sequence variations from dbSNP and Humsavar for BNIP3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs928162 -- 131,978,800(+) AAAAA(A/G)CCTGA intron-variant
rs1050704 -- 131,973,082(-) AACAG(A/G/T)GCTTC reference, synonymous-codon, missense
rs2282056 -- 131,982,787(+) GGCGC(C/T)TGGTC upstream-variant-2KB
rs2379210 -- 131,981,356(+) TTGGT(A/G)TTTGG intron-variant
rs3087296 -- 131,972,039(+) AACAC(-/TG)ATCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BNIP3 Gene

Variant ID Type Subtype PubMed ID
nsv896117 CNV Loss 21882294
nsv825650 CNV Gain 20364138
nsv825651 CNV Gain 20364138

Relevant External Links for BNIP3 Gene

HapMap Linkage Disequilibrium report
BNIP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BNIP3 Gene

Disorders for BNIP3 Gene

(1) University of Copenhagen DISEASES for BNIP3 Gene

(18) Novoseek inferred disease relationships for BNIP3 Gene

Disease -log(P) Hits PubMed IDs
acidosis 44.4 8
tumors 41.8 39
cancer 40.5 17
pancreatic cancer 39.5 27
solid tumor 38.9 3

Relevant External Links for BNIP3

Genetic Association Database (GAD)
BNIP3
Human Genome Epidemiology (HuGE) Navigator
BNIP3
genes like me logo Genes that share disorders with BNIP3: view

No data available for UniProtKB/Swiss-Prot for BNIP3 Gene

Publications for BNIP3 Gene

  1. Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines. (PMID: 18371312) Cao W. … Lu H. (Biochim. Biophys. Acta 2008) 3 4 23
  2. S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3. (PMID: 19935772) Ghavami S. … Los M. (Cell Res. 2010) 3 4 23
  3. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. (PMID: 7954800) Boyd J.M. … Chinnadurai G. (Cell 1994) 2 3 4
  4. Intermonomer hydrogen bonds enhance GxxxG-driven dimerization of the BNIP3 transmembrane domain: roles for sequence context in helix-helix association in membranes. (PMID: 20026130) Lawrie C.M. … MacKenzie K.R. (J. Mol. Biol. 2010) 3 23
  5. The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. (PMID: 9396766) Chen G. … Greenberg A.H. (J. Exp. Med. 1997) 3 4

Products for BNIP3 Gene

Sources for BNIP3 Gene

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