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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BNIP2 Gene

protein-coding   GIFtS: 65
GCID: GC15M059951

BCL2/Adenovirus E1B 19kDa Interacting Protein 2

(Previous name: BCL2/adenovirus E1B 19kD-interacting protein 2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BCL2/Adenovirus E1B 19kDa Interacting Protein 21 2
NIP22 3
BCL2/Adenovirus E1B 19kD-Interacting Protein 21
BNIP-22
BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 22

External Ids:    HGNC: 10831   Entrez Gene: 6632   Ensembl: ENSG000001402997   OMIM: 6032925   UniProtKB: Q129823   

Export aliases for BNIP2 gene to outside databases

Previous GC identifers: GC15M055513 GC15M053003 GC15M057534 GC15M057671 GC15M057742 GC15M036777


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BNIP2 Gene:
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the
E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with
E1B 19 kDa-like sequences of BCL2, another apoptotic protector. (provided by RefSeq, Mar 2011)

GeneCards Summary for BNIP2 Gene: 
BNIP2 (BCL2/adenovirus E1B 19kDa interacting protein 2) is a protein-coding gene. Diseases associated with BNIP2 include narcolepsy, and non-hodgkin lymphoma, and among its related super-pathways are Myogenesis and Axon guidance. GO annotations related to this gene include GTPase activator activity and calcium ion binding. An important paralog of this gene is PRUNE2.

UniProtKB/Swiss-Prot: BNIP2_HUMAN, Q12982
Function: Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins

Gene Wiki entry for BNIP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BNIP2 gene promoter:
         Max1   Sox5   AML1a   POU6F1 (c2)   CUTL1   HNF-3beta   RORalpha1   Cart-1   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBNIP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BNIP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BNIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q21.3

BNIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BNIP2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M059951:  view genomic region     (about GC identifiers)

Start:
59,951,345 bp from pter      End:
59,981,733 bp from pter
Size:
30,389 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BNIP2_HUMAN, Q12982 (See protein sequence)
Recommended Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 2  
Size: 314 amino acids; 36018 Da
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and
to other cytoplasmic structures
Secondary accessions: B4DS94
Alternative splicing: 2 isoforms:  Q12982-1   Q12982-2   

Explore the universe of human proteins at neXtProt for BNIP2: NX_Q12982

Explore proteomics data for BNIP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12982

  • BNIP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BNIP2 Protein Expression
    REFSEQ proteins: NP_004321.2  
    ENSEMBL proteins: 
     ENSP00000267859   ENSP00000475320   ENSP00000393644   ENSP00000412767   ENSP00000398364  
    Reactome Protein details: Q12982
    Human Recombinant Protein Products for BNIP2: 
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    Novus Biologicals BNIP2 Protein
    Novus Biologicals BNIP2 Lysate
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for BNIP2 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA7954800
    GO:0005737cytoplasm IDA7954800
    GO:0005814centriole ----
    GO:0005829cytosol TAS--
    GO:0031616spindle pole centrosome ----

    BNIP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR022181 Bcl2-/adenovirus-E1B
     IPR001251 CRAL-TRIO_dom

    Graphical View of Domain Structure for InterPro Entry Q12982

    ProtoNet protein and cluster: Q12982

    1 Blocks protein domain: IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)

    UniProtKB/Swiss-Prot: BNIP2_HUMAN, Q12982
    Similarity: Contains 1 CRAL-TRIO domain


    BNIP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BNIP2_HUMAN, Q12982
    Function: Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity TAS10799524
    GO:0005509calcium ion binding TAS7954800
    GO:0005515protein binding IPI10381623
         
    BNIP2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for BNIP2:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BNIP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BNIP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BNIP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BNIP2 

    miRNA
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    miRTarBase miRNAs that target BNIP2:
    hsa-mir-20a (MIRT005481)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BNIP2
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate BNIP2 (see all 37):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-105 hsa-miR-93 hsa-miR-4325 hsa-miR-23a hsa-miR-526b* hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidBNIP2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNIP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BNIP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    2Axon guidance
    Developmental Biology0.69
    3G-protein signaling Regulation of CDC42 activity
    G-protein signaling Regulation of CDC42 activity1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for BNIP2
        G-protein signaling Regulation of CDC42 activity


    1 GeneGo (Thomson Reuters) Pathway for BNIP2
        G-protein signaling Regulation of CDC42 activity

    3        Reactome Pathways for BNIP2
        Developmental Biology
    Myogenesis
    CDO in myogenesis



    BNIP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BNIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for BNIP2 (Q129822, 3 ENSP000002678594) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438892, 3, ENSP000003421364MINT-68383 I2D: score=5 STRING: ENSP00000342136
    ARHGAP1Q079603, ENSP000003104914I2D: score=4 STRING: ENSP00000310491
    BCL2P104153, ENSP000003296234I2D: score=4 STRING: ENSP00000329623
    BNIPLQ7Z4653, ENSP000003579274I2D: score=3 STRING: ENSP00000357927
    ARHGAP8P852983, ENSP000003744244I2D: score=1 STRING: ENSP00000374424
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001824blastocyst development ----
    GO:0006915apoptotic process IPI7954800
    GO:0042692muscle cell differentiation TAS--
    GO:0043066negative regulation of apoptotic process TAS7954800
    GO:0043410positive regulation of MAPK cascade ----

    BNIP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BNIP2

    Search CenterWatch for drugs/clinical trials and news about BNIP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BNIP2 gene: 
    NM_004330.2  

    Unigene Cluster for BNIP2:

    BCL2/adenovirus E1B 19kDa interacting protein 2
    Hs.646490  [show with all ESTs]
    Unigene Representative Sequence: NM_004330
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267859(uc010uhb.2 uc010uhc.2) ENST00000478981 ENST00000607373
    ENST00000439052 ENST00000415213 ENST00000560776 ENST00000448414 ENST00000464390
    ENST00000560458 ENST00000417312 ENST00000557987 ENST00000477543
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BNIP2
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate BNIP2 (see all 37):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-105 hsa-miR-93 hsa-miR-4325 hsa-miR-23a hsa-miR-526b* hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidBNIP2 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BNIP2
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    Additional mRNA sequence: 

    AK090501.1 AK299628.1 AK308237.1 BC002461.2 U15173.1 

    20 DOTS entries:

    DT.416710  DT.100826761  DT.213139  DT.121030582  DT.121030500  DT.95290740  DT.100826763  DT.100826759 
    DT.100026742  DT.97820175  DT.121030562  DT.91883088  DT.100026743  DT.100826762  DT.95083121  DT.99929330 
    DT.121030558  DT.91985793  DT.121030528  DT.100826757 

    2 AceView cDNA sequences:

    T31116 CR597487 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for BNIP2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                    -                             -     -     -                                         -     -               
    SP2:                                                                                                                              
    SP3:                    -                             -           -                                                               
    SP4:                                                  -     -     -                                                               
    SP5:                    -                                                                                                         


    ECgene alternative splicing isoforms for BNIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BNIP2 expression in normal human tissues (normalized intensities)      BNIP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGACAATA
    BNIP2 Expression
    About this image


    BNIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             monocytes   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   

    See BNIP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BNIP2

    SOURCE GeneReport for Unigene cluster: Hs.646490
        SABiosciences Expression via Pathway-Focused PCR Arrays including BNIP2: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BNIP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNIP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BNIP2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bnip21 , 5 BCL2/adenovirus E1B interacting protein 21, 5 86.62(n)1
    92.68(a)1
      9 (39.15 cM)5
    121751  NM_001008238.21  NP_001008239.11 
     699894665 
    chicken
    (Gallus gallus)
    Aves BNIP21 BCL2/adenovirus E1B 19kDa interacting protein 2 84.03(n)
    90.61(a)
      415379  XM_413765.3  XP_413765.1 
    lizard
    (Anolis carolinensis)
    Reptilia BNIP26
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL343428.1(288353-303177)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84592 Xenopus laevis transcribed sequence with weak similarity more 79.27(n)    BM261386.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bnip22 BCL2/adenovirus E1B interacting protein 2 75.66(n)   394197  AY423003.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG115933   -- 48(a)   64A4   --


    ENSEMBL Gene Tree for BNIP2 (if available)
    TreeFam Gene Tree for BNIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BNIP2 gene
    PRUNE22  ATCAY2  BNIPL2  
    6 SIMAP similar genes for BNIP2 using alignment to 4 protein entries:     BNIP2_HUMAN (see all proteins):
    PRUNE2    ATCAY    BNIPL    PRR5-ARHGAP8    ARHGAP8    ARHGAP1

    BNIP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/802 SNPs in BNIP2 are shown (see all 802)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61514931,2
    F--36795442(-) ACCTTA/TAGTTT 1 -- int11Minor allele frequency- T:0.03NS 144
    rs349921571,2
    C--36801504(+) TTTCA-/TCCTTT 1 -- int10--------
    rs680806541,2
    C--36801504(+) TTTCAC/TCCTTT 1 -- int10--------
    rs1461680951,2
    C--36802021(+) TATCT-/TATA  
            
    TATAT
    1 -- int10--------
    rs339409921,2
    C--36804280(+) AAAAA-/AG/G  
            
    AAAAG
    1 -- us2k10--------
    rs61515861,2
    C,F,A,H--40015674(-) TGCTCA/TCATTT 1 -- ds500126Minor allele frequency- T:0.34NS EA NA WA 2938
    rs1847403431,2
    --40015689(+) ATAATA/CGTTTT 1 -- ds50010--------
    rs1144813061,2
    C,F--40015704(+) CAATTC/GACTGT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1904139981,2
    --40015714(+) TAATGA/CCATTA 1 -- ds50010--------
    rs1446045251,2
    --40015723(+) TAGTTC/GAGGAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for BNIP2 (59951345 - 59981733 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BNIP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523274CNV Loss19592680
    nsv527307CNV Gain19592680
    nsv904254CNV Gain21882294
    nsv7266OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603292    OMIM disorders: --

    4 diseases for BNIP2:    About MalaCards
    narcolepsy    non-hodgkin lymphoma    hodgkin's lymphoma    neuronitis


    BNIP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BNIP2
    Human Genome Epidemiology (HuGE) Navigator: BNIP2 (3 documents)

    Export disorders for BNIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BNIP2 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with BNIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. (PubMed id 7954800)1, 2, 3 Boyd J.M.... Chinnadurai G. (1994)
    2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    3. Germline variation in apoptosis pathway genes and ris k of non-Hodgkin's lymphoma. (PubMed id 20855536)1, 4 Kelly J.L....Cerhan J.R. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain. (PubMed id 15652341)1, 9 Zhou Y.T....Low B.C. (2005)
    6. Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2. (PubMed id 11744098)1, 9 Belcredito S....Maggi A. (2001)
    7. Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1. (PubMed id 12944407)1, 9 Shang X.... Low B.C. (2003)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 663 HGNC: 1083 AceView: BNIP2 Ensembl:ENSG00000140299 euGenes: HUgn663
    ECgene: BNIP2 H-InvDB: BNIP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BNIP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BNIP2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/bnip2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BNIP2 gene:
    Search GeneIP for patents involving BNIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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