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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BNIP2 Gene

protein-coding   GIFtS: 60
GCID: GC15M059951

BCL2/adenovirus E1B 19kDa interacting protein 2

(Previous name: BCL2/adenovirus E1B 19kD-interacting protein 2 )
 Explore 3 diseases affiliated with
BNIP2 via our new
 Human Malady Compendium 
Biological research products
for BNIP2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
BCL2/Adenovirus E1B 19kDa Interacting Protein 21 2
BNIP-21 2
NIP22 3
Nip21
BCL2/Adenovirus E1B 19kD-Interacting Protein 21
BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 22

External Ids:    HGNC: 10831   Entrez Gene: 6632   Ensembl: ENSG000001402997   OMIM: 6032925   UniProtKB: Q129823   

Export aliases for BNIP2 gene to outside databases

Previous GC identifers: GC15M055513 GC15M053003 GC15M057534 GC15M057671 GC15M057742 GC15M036777


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BNIP2:
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19
kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19
kDa-like sequences of BCL2, another apoptotic protector. (provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: BNIP2_HUMAN, Q12982
Function: Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins

Gene Wiki entry for BNIP2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BNIP2 gene promoter:
         Max1   Sox5   AML1a   POU6F1 (c2)   CUTL1   HNF-3beta   RORalpha1   Cart-1   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBNIP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BNIP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BNIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q21.3

BNIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BNIP2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M059951:  view genomic region     (about GC identifiers)

Start:
59,951,345 bp from pter      End:
59,981,733 bp from pter
Size:
30,389 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BNIP2_HUMAN, Q12982 (See protein sequence)
Recommended Name: BCL2/adenovirus E1B 19 kDa protein-interacting protein 2  
Size: 314 amino acids; 36018 Da
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to
other cytoplasmic structures
Secondary accessions: B4DS94
Alternative splicing: 2 isoforms:  Q12982-1   Q12982-2   

Explore the universe of human proteins at neXtProt for BNIP2: NX_Q12982

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q12982

  • BNIP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004321.2  
    ENSEMBL proteins: 
     ENSP00000267859   ENSP00000393644   ENSP00000412767   ENSP00000398364  
    Reactome Protein details: Q12982
    Human Recombinant Protein Products: 
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    Novus Biologicals BNIP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BNIP2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA7954800
    GO:0005737cytoplasm IDA7954800
    GO:0005829cytosol TAS--
    GO:0043231intracellular membrane-bounded organelle IDA7954800
    GO:0048471perinuclear region of cytoplasm IEA--


    BNIP2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    BNIP2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR022181 Bcl2-/adenovirus-E1B
     IPR001251 CRAL-TRIO_dom

    Graphical View of Domain Structure for InterPro Entry Q12982

    ProtoNet protein and cluster: Q12982

    1 Blocks protein family: IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)

    UniProtKB/Swiss-Prot: BNIP2_HUMAN, Q12982
    Similarity: Contains 1 CRAL-TRIO domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: BNIP2_HUMAN, Q12982
    Function: Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins

    miRNA
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    miRTarBase miRNAs that target BNIP2:
    hsa-mir-20a (MIRT005481)

    OriGene 3'-UTR Clone: BNIP2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BNIP2
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate BNIP2 (see all 37):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-105 hsa-miR-93 hsa-miR-4325 hsa-miR-23a hsa-miR-526b* hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidBNIP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BNIP2 (see all 7)
    OriGene shRNA RFP: BNIP2
    OriGene siRNA: BNIP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BNIP2

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BNIP2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNIP2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity TAS10799524
    GO:0005509calcium ion binding TAS7954800
    GO:0005515protein binding IPI7954800


    BNIP2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for BNIP2:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of p38 alpha/beta MAPK
    Activation of p38 alpha/beta MAPK1.00
    CDO in myogenesis0.55
    Nuclear translocation of p38 MAPK0.94
    Myogenesis0.55
    2G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of CDC42 activity0.25
    G-protein signaling_Regulation of CDC42 activity0.25
    3Axon guidance
    Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for BNIP2
        G-protein signaling Regulation of CDC42 activity


    1 GeneGo (Thomson Reuters) Pathway for BNIP2
        G-protein signaling Regulation of CDC42 activity

    5        Reactome Pathways for BNIP2
        Activation of p38 alpha/beta MAPK
    Developmental Biology
    Myogenesis
    Nuclear translocation of p38 MAPK
    CDO in myogenesis



    BNIP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BNIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for BNIP2 (Q129822, 3 ENSP000002678594) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438892, 3, ENSP000003421364MINT-68383 I2D: score=5 STRING: ENSP00000342136
    ARHGAP1Q079603, ENSP000003104914I2D: score=4 STRING: ENSP00000310491
    BCL2P104153, ENSP000003296234I2D: score=4 STRING: ENSP00000329623
    BNIPLQ7Z4653, ENSP000003579274I2D: score=3 STRING: ENSP00000357927
    ARHGAP8P852983, ENSP000003744244I2D: score=1 STRING: ENSP00000374424
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IPI7954800
    GO:0042692muscle cell differentiation TAS--
    GO:0043066negative regulation of apoptotic process TAS7954800
    GO:0043410positive regulation of MAPK cascade ----
    GO:0043547positive regulation of GTPase activity TAS10799524


    BNIP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BNIP2
    Search CenterWatch for drugs/clinical trials and news about BNIP2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BNIP2 gene: 
    NM_004330.2  

    Unigene Cluster for BNIP2:

    BCL2/adenovirus E1B 19kDa interacting protein 2
    Hs.646490  [show with all ESTs]
    Unigene Representative Sequence: NM_004330
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267859(uc010uhb.2 uc010uhc.2) ENST00000478981 ENST00000439052
    ENST00000415213 ENST00000560776 ENST00000448414 ENST00000464390 ENST00000560458
    ENST00000417312 ENST00000557987 ENST00000477543

    miRNA
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    OriGene 3'-UTR Clone: BNIP2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BNIP2
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate BNIP2 (see all 37):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-105 hsa-miR-93 hsa-miR-4325 hsa-miR-23a hsa-miR-526b* hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidBNIP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BNIP2 (see all 7)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BNIP2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BNIP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BNIP2

    Additional cDNA sequence: 

    AK090501.1 AK299628.1 AK308237.1 BC002461.2 U15173.1 

    20 DOTS entries:

    DT.416710  DT.100826761  DT.213139  DT.121030582  DT.121030500  DT.95290740  DT.100826763  DT.100826759 
    DT.100026742  DT.97820175  DT.121030562  DT.91883088  DT.100026743  DT.100826762  DT.95083121  DT.99929330 
    DT.121030558  DT.91985793  DT.121030528  DT.100826757 

    2 AceView cDNA sequences:

    CR597487 T31116 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for BNIP2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                    -                             -     -     -                                         -     -               
    SP2:                                                                                                                              
    SP3:                    -                             -           -                                                               
    SP4:                                                  -     -     -                                                               
    SP5:                    -                                                                                                         


    ECgene alternative splicing isoforms for BNIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BNIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGACAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See BNIP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BNIP2

    SOURCE GeneReport for Unigene cluster: Hs.646490
        SABiosciences Expression via Pathway-Focused PCR Arrays including BNIP2: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNIP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BNIP2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves BNIP21 BCL2/adenovirus E1B 19kDa interacting protein 2 84.03(n)
    90.61(a)
      415379  XM_413765.3  XP_413765.1 
    lizard
    (Anolis carolinensis)
    Reptilia BNIP26
    --
    79(a)
    1 ↔ 1
    GL343428.1(288353-297803)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84592 Xenopus laevis transcribed sequence with weak similarity more 79.27(n)    BM261386.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bnip22 BCL2/adenovirus E1B interacting protein 2 75.66(n)   394197  AY423003.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG115933   -- 48(a)   64A4   --


    ENSEMBL Gene Tree for BNIP2 (if available)
    TreeFam Gene Tree for BNIP2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BNIP2 gene
    PRUNE22  ARHGAP82  ATCAY2  PRR5-ARHGAP82  ARHGAP12  BNIPL2  
    6 SIMAP similar genes for BNIP2 using alignment to 4 protein entries:     BNIP2_HUMAN (see all proteins):
    PRUNE2    ATCAY    BNIPL    PRR5-ARHGAP8    ARHGAP8    ARHGAP1

    BNIP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/677 NCBI SNPs in BNIP2 are shown (see all 677    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1144813061,2
    C,F,--36776555(+) CAATTC/GACTGT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs61515851,2
    C,H--36777326(-) ATGTGA/GTGAGT 1 -- ut315Minor allele frequency- G:0.00NS EA 510
    rs1147654591,2
    C,F,--36777389(+) ACACAT/CAGCTT 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs10570621,2
    C,F,H,--36777480(-) GGTTTG/CTATAT 1 -- ut31 ese318Minor allele frequency- C:0.02NS MN EA NA 1672
    rs61515841,2
    H--36778061(-) TCACTG/ACTGTA 1 -- ut31 ese35Minor allele frequency- A:0.00NS EA 522
    rs61515791,2
    C,F,H,--36778899(-) CCTACC/TACAGC 1 -- int15Minor allele frequency- T:0.01NS EA 580
    rs790213741,2
    C,--36779142(+) AAGGCC/TGGATG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs2014972851,2
    C--36780243(-) ATACAA/GATTGT 1 -- int10--------
    rs61515771,2
    C,F,H,--36780270(-) CAACTG/AGATGC 1 -- int15Minor allele frequency- A:0.01NS EA 594
    rs61515731,2
    C,--36780784(-) gtgcaA/Gtggcc 1 -- int11Minor allele frequency- G:0.01NS 176

    HapMap Linkage Disequilibrium report for BNIP2 (59951345 - 59981733 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BNIP2: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    BNIP2 for disorders           About GeneDecksing

    OMIM gene information: 603292    OMIM disorders: --

    3 diseases for BNIP2:    About MalaCards
    non-hodgkin lymphoma    hodgkin's lymphoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: BNIP2 (3 documents)

    Export disorders for BNIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BNIP2 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with BNIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. (PubMed id 7954800)1, 2, 3 Boyd J.M.... Chinnadurai G. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain. (PubMed id 15652341)1, 9 Zhou Y.T....Low B.C. (2005)
    4. Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2. (PubMed id 11744098)1, 9 Belcredito S....Maggi A. (2001)
    5. Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1. (PubMed id 12944407)1, 9 Shang X.... Low B.C. (2003)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells. (PubMed id 21130087)1 Park G....Kim J.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 663 HGNC: 1083 AceView: BNIP2 Ensembl:ENSG00000140299 euGenes: HUgn663
    ECgene: BNIP2 H-InvDB: BNIP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BNIP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BNIP2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/bnip2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BNIP2 gene:
    Search GeneIP for patents involving BNIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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