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Aliases for BNIP2 Gene

Aliases for BNIP2 Gene

  • BCL2 Interacting Protein 2 2 3
  • BCL2/Adenovirus E1B 19kDa Interacting Protein 2 2 3 5
  • NIP2 3 4
  • BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 2 3
  • BNIP-2 3

External Ids for BNIP2 Gene

Previous GeneCards Identifiers for BNIP2 Gene

  • GC15M055513
  • GC15M053003
  • GC15M057534
  • GC15M057671
  • GC15M057742
  • GC15M059951
  • GC15M036777

Summaries for BNIP2 Gene

Entrez Gene Summary for BNIP2 Gene

  • This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for BNIP2 Gene

BNIP2 (BCL2 Interacting Protein 2) is a Protein Coding gene. Among its related pathways are G-protein signaling_Regulation of CDC42 activity and CDO in myogenesis. GO annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is PRUNE2.

UniProtKB/Swiss-Prot for BNIP2 Gene

  • Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.

Gene Wiki entry for BNIP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNIP2 Gene

Genomics for BNIP2 Gene

Regulatory Elements for BNIP2 Gene

Enhancers for BNIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BNIP2 on UCSC Golden Path with GeneCards custom track

Promoters for BNIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BNIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BNIP2 Gene

Chromosome:
15
Start:
59,659,146 bp from pter
End:
59,689,534 bp from pter
Size:
30,389 bases
Orientation:
Minus strand

Genomic View for BNIP2 Gene

Genes around BNIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BNIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BNIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIP2 Gene

Proteins for BNIP2 Gene

  • Protein details for BNIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12982-BNIP2_HUMAN
    Recommended name:
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
    Protein Accession:
    Q12982
    Secondary Accessions:
    • B4DS94

    Protein attributes for BNIP2 Gene

    Size:
    314 amino acids
    Molecular mass:
    36018 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BNIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BNIP2 Gene

Post-translational modifications for BNIP2 Gene

  • Ubiquitination at Lys 219, Lys 228, and Lys 267
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BNIP2 Gene

Domains & Families for BNIP2 Gene

Gene Families for BNIP2 Gene

Suggested Antigen Peptide Sequences for BNIP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q12982

UniProtKB/Swiss-Prot:

BNIP2_HUMAN :
  • Contains 1 CRAL-TRIO domain.
Domain:
  • Contains 1 CRAL-TRIO domain.
genes like me logo Genes that share domains with BNIP2: view

Function for BNIP2 Gene

Molecular function for BNIP2 Gene

UniProtKB/Swiss-Prot Function:
Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.

Gene Ontology (GO) - Molecular Function for BNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS 10799524
GO:0005509 calcium ion binding TAS 7954800
GO:0005515 protein binding IPI 7954800
GO:0042802 identical protein binding IBA --
genes like me logo Genes that share ontologies with BNIP2: view
genes like me logo Genes that share phenotypes with BNIP2: view

Animal Models for BNIP2 Gene

MGI Knock Outs for BNIP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BNIP2 Gene

Localization for BNIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BNIP2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BNIP2 Gene COMPARTMENTS Subcellular localization image for BNIP2 gene
Compartment Confidence
cytosol 5
nucleus 5
golgi apparatus 2
plasma membrane 2
cytoskeleton 1
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA 7954800
GO:0005737 cytoplasm IDA 7954800
GO:0005814 centriole IEA --
GO:0005829 cytosol TAS --
GO:0031616 spindle pole centrosome IEA --
genes like me logo Genes that share ontologies with BNIP2: view

Pathways & Interactions for BNIP2 Gene

genes like me logo Genes that share pathways with BNIP2: view

Pathways by source for BNIP2 Gene

3 Reactome pathways for BNIP2 Gene
1 GeneGo (Thomson Reuters) pathway for BNIP2 Gene

SIGNOR curated interactions for BNIP2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for BNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IPI 7954800
GO:0043066 negative regulation of apoptotic process TAS 7954800
GO:0043410 positive regulation of MAPK cascade IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0045666 positive regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with BNIP2: view

Drugs & Compounds for BNIP2 Gene

No Compound Related Data Available

Transcripts for BNIP2 Gene

mRNA/cDNA for BNIP2 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BNIP2 Gene

BCL2/adenovirus E1B 19kDa interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BNIP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2:
SP3: - - -
SP4: - - -
SP5: -
SP6: -
SP7:

Relevant External Links for BNIP2 Gene

GeneLoc Exon Structure for
BNIP2
ECgene alternative splicing isoforms for
BNIP2

Expression for BNIP2 Gene

mRNA expression in normal human tissues for BNIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BNIP2 Gene

This gene is overexpressed in Pancreas (22.9), Testis (19.0), Platelet (7.7), and Monocytes (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BNIP2 Gene



Protein tissue co-expression partners for BNIP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BNIP2 Gene:

BNIP2

SOURCE GeneReport for Unigene cluster for BNIP2 Gene:

Hs.646490
genes like me logo Genes that share expression patterns with BNIP2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BNIP2 Gene

Orthologs for BNIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BNIP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BNIP2 34
  • 94.48 (n)
  • 98.41 (a)
BNIP2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BNIP2 34
  • 93.72 (n)
  • 95.23 (a)
BNIP2 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bnip2 34
  • 86.52 (n)
  • 92.68 (a)
Bnip2 16
Bnip2 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BNIP2 34
  • 99.92 (n)
  • 99.75 (a)
BNIP2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bnip2 34
  • 87.07 (n)
  • 93.31 (a)
oppossum
(Monodelphis domestica)
Mammalia BNIP2 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BNIP2 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves BNIP2 34
  • 84.14 (n)
  • 90.61 (a)
BNIP2 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BNIP2 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bnip2 34
  • 78.09 (n)
  • 81.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8459 34
zebrafish
(Danio rerio)
Actinopterygii bnip2 34
LOC100332015 34
  • 72.45 (n)
  • 80.75 (a)
bnip2 35
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11593 36
  • 48 (a)
CG11593 35
  • 25 (a)
OneToMany
Species where no ortholog for BNIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BNIP2 Gene

ENSEMBL:
Gene Tree for BNIP2 (if available)
TreeFam:
Gene Tree for BNIP2 (if available)

Paralogs for BNIP2 Gene

Paralogs for BNIP2 Gene

(6) SIMAP similar genes for BNIP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BNIP2: view

Variants for BNIP2 Gene

Sequence variations from dbSNP and Humsavar for BNIP2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs6151509 - 59,680,288(-) TGATA(C/G/T)TATTG reference, missense
rs2899649 -- 59,675,306(+) AGTTA(A/T)GGTTA intron-variant
rs2899650 -- 59,690,798(+) AGCCA(C/G)TTGGG upstream-variant-2KB
rs3053099 -- 59,689,778(-) TTCAC(-/ATT)ATTAT upstream-variant-2KB
rs3053100 -- 59,690,689(+) aAAaa(-/AA/AAAAAA)gagac upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BNIP2 Gene

Variant ID Type Subtype PubMed ID
esv3569653 CNV gain 25503493
esv3636646 CNV gain 21293372
esv3636647 CNV gain 21293372
nsv1043693 CNV loss 25217958
nsv1108960 CNV deletion 24896259
nsv523274 CNV loss 19592680
nsv527307 CNV gain 19592680
nsv569605 CNV loss 21841781
nsv7266 OTHER inversion 18451855
nsv984080 CNV duplication 23825009

Variation tolerance for BNIP2 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.33; 94.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BNIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BNIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BNIP2 Gene

Disorders for BNIP2 Gene

Relevant External Links for BNIP2

Genetic Association Database (GAD)
BNIP2
Human Genome Epidemiology (HuGE) Navigator
BNIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BNIP2

No disorders were found for BNIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BNIP2 Gene

Publications for BNIP2 Gene

  1. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. (PMID: 7954800) Boyd J.M. … Chinnadurai G. (Cell 1994) 2 3 4 65
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 65
  3. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly J.L. … Cerhan J.R. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 65
  4. BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain. (PMID: 15652341) Zhou Y.T. … Low B.C. (Exp. Cell Res. 2005) 3 22 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for BNIP2 Gene

Sources for BNIP2 Gene

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