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Aliases for BNIP1 Gene

Aliases for BNIP1 Gene

  • BCL2 Interacting Protein 1 2 3 5
  • BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 1 3 4
  • BCL2/Adenovirus E1B 19kDa Interacting Protein 1 2 3
  • Transformation-Related Gene 8 Protein 3 4
  • TRG-8 3 4
  • NIP1 3 4
  • Vesicle Transport Protein SEC20 3
  • SEC20L 4
  • SEC20 3

External Ids for BNIP1 Gene

Previous GeneCards Identifiers for BNIP1 Gene

  • GC05P172829
  • GC05P173273
  • GC05P172507
  • GC05P172552
  • GC05P172504
  • GC05P167665

Summaries for BNIP1 Gene

Entrez Gene Summary for BNIP1 Gene

  • This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]

GeneCards Summary for BNIP1 Gene

BNIP1 (BCL2 Interacting Protein 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. GO annotations related to this gene include SNAP receptor activity.

UniProtKB/Swiss-Prot for BNIP1 Gene

  • SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNIP1 Gene

Genomics for BNIP1 Gene

Regulatory Elements for BNIP1 Gene

Enhancers for BNIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F173050 1.2 Ensembl ENCODE 27.1 -93.1 -93090 2.6 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 RAD21 ZNF335 ZNF143 RCOR1 BNIP1 SNORA74B ENSG00000254328 ATP6V0E1 ENSG00000253172 ENSG00000207210 GC05M173053 GC05P173039
GH05F173010 1.2 Ensembl ENCODE 18.7 -132.9 -132941 4.2 HDGF PKNOX1 ATF1 ZNF133 ARID4B SIN3A FEZF1 ZNF121 ZNF143 FOS BNIP1 CREBRF ENSG00000207210 ENSG00000254328 ATP6V0E1 ENSG00000253172 LOC100268168 RPL26L1 ENSG00000254295 GC05P173022
GH05F173014 1.6 FANTOM5 Ensembl ENCODE 10.9 -127.7 -127742 4.6 ATF1 PKNOX1 ARID4B ZNF766 FOS DEK NFYC NCOA1 PPARG TBX21 CREBRF ENSG00000207210 ENSG00000254328 ATP6V0E1 LOC100268168 RPL26L1 ENSG00000254295 ENSG00000253172 BNIP1 LOC401218
GH05F173027 1.2 Ensembl ENCODE 9.9 -115.1 -115142 3.0 ATF1 PKNOX1 ARID4B KLF13 REST PPARG ZNF518A KAT8 MEF2D SMARCA4 ENSG00000207210 CREBRF BNIP1 ATP6V0E1 GC05P173039 GC05P173021
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BNIP1 on UCSC Golden Path with GeneCards custom track

Promoters for BNIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for BNIP1 Gene

173,144,442 bp from pter
173,164,387 bp from pter
19,946 bases
Plus strand

Genomic View for BNIP1 Gene

Genes around BNIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BNIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BNIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIP1 Gene

Proteins for BNIP1 Gene

  • Protein details for BNIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vesicle transport protein SEC20
    Protein Accession:
    Secondary Accessions:
    • D3DQM3
    • D3DQM4
    • D3DQM5
    • D3DQM6
    • O75622
    • O75623
    • O75624
    • Q6K044
    • Q96FG4

    Protein attributes for BNIP1 Gene

    228 amino acids
    Molecular mass:
    26132 Da
    Quaternary structure:
    • Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2 and adenovirus E1B 19 kDa protein.
    • Silencing of BNIP1 disrupts ER morphology.

    Alternative splice isoforms for BNIP1 Gene


neXtProt entry for BNIP1 Gene

Post-translational modifications for BNIP1 Gene

  • Lys-63-linked polyubiquitination by RNF185 allows recruiting of autophagy receptor SQSTM1, which simultaneously binds both ubiquitin and LC3 to link ubiquitination and autophagy.
  • Ubiquitination at Lys 221
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BNIP1 Gene

Domains & Families for BNIP1 Gene

Gene Families for BNIP1 Gene

Protein Domains for BNIP1 Gene


Suggested Antigen Peptide Sequences for BNIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SEC20 family.
  • Belongs to the SEC20 family.
genes like me logo Genes that share domains with BNIP1: view

Function for BNIP1 Gene

Molecular function for BNIP1 Gene

UniProtKB/Swiss-Prot Function:
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy.

Gene Ontology (GO) - Molecular Function for BNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IDA 15272311
GO:0005515 protein binding IPI 7954800
genes like me logo Genes that share ontologies with BNIP1: view
genes like me logo Genes that share phenotypes with BNIP1: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BNIP1 Gene

Localization for BNIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BNIP1 Gene

Mitochondrion. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BNIP1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA 7954800
GO:0005737 cytoplasm IDA 7954800
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA 15272311
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with BNIP1: view

Pathways & Interactions for BNIP1 Gene

genes like me logo Genes that share pathways with BNIP1: view

Gene Ontology (GO) - Biological Process for BNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IPI 7954800
GO:0007029 endoplasmic reticulum organization IMP 15272311
genes like me logo Genes that share ontologies with BNIP1: view

No data available for SIGNOR curated interactions for BNIP1 Gene

Transcripts for BNIP1 Gene

Unigene Clusters for BNIP1 Gene

BCL2/adenovirus E1B 19kDa interacting protein 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BNIP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for BNIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BNIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BNIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BNIP1 Gene

This gene is overexpressed in Cervix (17.2), Pancreas (7.8), and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BNIP1 Gene

Protein tissue co-expression partners for BNIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BNIP1 Gene:


SOURCE GeneReport for Unigene cluster for BNIP1 Gene:


mRNA Expression by UniProt/SwissProt for BNIP1 Gene:

Tissue specificity: Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.
genes like me logo Genes that share expression patterns with BNIP1: view

No data available for mRNA differential expression in normal tissues for BNIP1 Gene

Orthologs for BNIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BNIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BNIP1 34 35
  • 99.71 (n)
(Canis familiaris)
Mammalia BNIP1 34 35
  • 91.81 (n)
(Bos Taurus)
Mammalia BNIP1 34 35
  • 89.62 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 89 (a)
-- 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia BNIP1 35
  • 89 (a)
(Rattus norvegicus)
Mammalia Bnip1 34
  • 86.99 (n)
(Mus musculus)
Mammalia Bnip1 34 16 35
  • 86.55 (n)
(Gallus gallus)
Aves BNIP1 34 35
  • 75.04 (n)
(Anolis carolinensis)
Reptilia BNIP1 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bnip1 34
  • 71.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64539 34
(Danio rerio)
Actinopterygii bnip1a 35
  • 74 (a)
bnip1b 34 35
  • 71.2 (n)
Dr.15880 34
fruit fly
(Drosophila melanogaster)
Insecta CG2023 34 35
  • 48.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000242 34
  • 46.86 (n)
Species where no ortholog for BNIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BNIP1 Gene

Gene Tree for BNIP1 (if available)
Gene Tree for BNIP1 (if available)

Paralogs for BNIP1 Gene

No data available for Paralogs for BNIP1 Gene

Variants for BNIP1 Gene

Sequence variations from dbSNP and Humsavar for BNIP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10214139 -- 173,149,572(+) TCTTG(G/T)GGTAT intron-variant
rs1050217 -- 173,154,366(+) GAGAA(A/C)CAACT reference, missense
rs1050259 -- 173,164,362(+) TAGAA(A/T)AAAAT utr-variant-3-prime
rs10546608 -- 173,159,478(+) TCATT(-/AAA)AAAAA intron-variant
rs10681333 -- 173,143,583(+) AAAAA(-/AAAAA)GAGAG upstream-variant-2KB

Variation tolerance for BNIP1 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BNIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BNIP1 Gene

Disorders for BNIP1 Gene

Relevant External Links for BNIP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BNIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BNIP1 Gene

Publications for BNIP1 Gene

  1. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PMID: 15272311) Nakajima K. … Tagaya M. (EMBO J. 2004) 2 3 4 64
  2. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. (PMID: 7954800) Boyd J.M. … Chinnadurai G. (Cell 1994) 2 3 4 64
  3. Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis. (PMID: 22306654) Feenstra B. … Melbye M. (Nat. Genet. 2012) 3 46 64
  4. RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. (PMID: 21931693) Tang F. … Tang J. (PLoS ONE 2011) 3 4 64
  5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64

Products for BNIP1 Gene

Sources for BNIP1 Gene

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