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BNIP1 Gene

protein-coding   GIFtS: 55
GCID: GC05P172504

BCL2/Adenovirus E1B 19kDa Interacting Protein 1

(Previous name: BCL2/adenovirus E1B 19kD-interacting protein 1)
  See BNIP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BCL2/Adenovirus E1B 19kDa Interacting Protein 11 2     BCL2/Adenovirus E1B 19kD-Interacting Protein 11
NIP12 3 5     SEC202
Transformation-Related Gene 8 Protein2 3     Vesicle Transport Protein SEC202
TRG-82 3     SEC20L3
BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 12 3     

External Ids:    HGNC: 10821   Entrez Gene: 6622   Ensembl: ENSG000001137347   OMIM: 6032915   UniProtKB: Q129813   

Export aliases for BNIP1 gene to outside databases

Previous GC identifers: GC05P172829 GC05P173273 GC05P172507 GC05P172552 GC05P167665


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BNIP1 Gene:
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the
E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with
E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle
transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with
identical N- and C-termini. (provided by RefSeq, Mar 2011)

GeneCards Summary for BNIP1 Gene:
BNIP1 (BCL2/adenovirus E1B 19kDa interacting protein 1) is a protein-coding gene. Diseases associated with BNIP1 include spindle cell hemangioma.

UniProtKB/Swiss-Prot: SEC20_HUMAN, Q12981
Function: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with
the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in
mitochondrial autophagy




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the BNIP1 gene promoter:
         GR   SRF   Sox5   AML1a   GR-beta   SRF (504 AA)   PPAR-alpha   FAC1   FOXO4   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBNIP1 promoter sequence
   Search Chromatin IP Primers for BNIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BNIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33-q34   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q33-q34

BNIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BNIP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P172504:  view genomic region     (about GC identifiers)

Start:
172,571,445 bp from pter      End:
172,591,390 bp from pter
Size:
19,946 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SEC20_HUMAN, Q12981 (See protein sequence)
Recommended Name: Vesicle transport protein SEC20  
Size: 228 amino acids; 26132 Da
Subunit: Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with
STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2 and adenovirus E1B 19 kDa
protein
Miscellaneous: Silencing of BNIP1 disrupts ER morphology
Secondary accessions: D3DQM3 D3DQM4 D3DQM5 D3DQM6 O75622 O75623 O75624 Q6K044 Q96FG4
Alternative splicing: 4 isoforms:  Q12981-4   Q12981-2   Q12981-1   Q12981-3   

Explore the universe of human proteins at neXtProt for BNIP1: NX_Q12981

Explore proteomics data for BNIP1 at MOPED

Post-translational modifications: 

  • 'Lys-63'-linked polyubiquitination by RNF185 allows recruiting of autophagy receptor SQSTM1, which simultaneously
    binds both ubiquitin and LC3 to link ubiquitination and autophagy1
  • Ubiquitination2 at Lys221
  • Modification sites at PhosphoSitePlus

  • See BNIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001196.2  NP_053581.2  NP_053582.2  NP_053583.2  

    ENSEMBL proteins: 
     ENSP00000231668   ENSP00000239215   ENSP00000239214   ENSP00000377365   ENSP00000429717  

    BNIP1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BNIP1

     
    Search eBioscience for Proteins for BNIP1 

     
    antibodies-online proteins for BNIP1 (5 products) 

     
    antibodies-online peptides for BNIP1

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    antibodies-online kits for BNIP1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005606 Sec20

    Graphical View of Domain Structure for InterPro Entry Q12981

    ProtoNet protein and cluster: Q12981

    UniProtKB/Swiss-Prot: SEC20_HUMAN, Q12981
    Similarity: Belongs to the SEC20 family


    Find genes that share domains with BNIP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SEC20_HUMAN, Q12981
    Function: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with
    the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in
    mitochondrial autophagy

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005484SNAP receptor activity IDA15272311
    GO:0005515protein binding IPI15272311
         
    Find genes that share ontologies with BNIP1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for BNIP1

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate BNIP1:
    hsa-miR-942 hsa-miR-1236
    SwitchGear 3'UTR luciferase reporter plasmidBNIP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BNIP1
    Predesigned siRNA for gene silencing in human, mouse, rat BNIP1

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    GenScript: all cDNA clones in your preferred vector (see all 4): BNIP1 (NM_001205)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNIP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SEC20_HUMAN, Q12981: Mitochondrion. Endoplasmic reticulum membrane; Single-pass type IV membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    cytosol2
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA7954800
    GO:0005737cytoplasm IDA7954800
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IDA15272311
    GO:0030176integral component of endoplasmic reticulum membrane TAS15272311

    Find genes that share ontologies with BNIP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BNIP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    SNARE interactions in vesicular transport0.40


    Find genes that share SuperPaths with BNIP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for BNIP1):
        SNARE interactions in vesicular transport

        Pathway & Disease-focused RT2 Profiler PCR Array including BNIP1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BNIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BNIP1 (Q129813 ENSP000002316684) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104153, ENSP000003296234I2D: score=3 STRING: ENSP00000329623
    NCBP1Q091613, ENSP000003642894I2D: score=2 STRING: ENSP00000364289
    NAPBQ9H1153, ENSP000003662254I2D: score=1 STRING: ENSP00000366225
    SQSTM1Q135013, ENSP000003744554I2D: score=1 STRING: ENSP00000374455
    STX18Q9P2W93, ENSP000003058104I2D: score=1 STRING: ENSP00000305810
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0006915apoptotic process IPI7954800
    GO:0007029endoplasmic reticulum organization IMP15272311
    GO:0016192vesicle-mediated transport IEA--
    GO:0016320endoplasmic reticulum membrane fusion IMP15272311

    Find genes that share ontologies with BNIP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BNIP1 (SEC20)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BNIP1 gene (4 alternative transcripts): 
    NM_001205.2  NM_013978.2  NM_013979.2  NM_013980.2  

    Unigene Cluster for BNIP1:

    BCL2/adenovirus E1B 19kDa interacting protein 1
    Hs.145726  [show with all ESTs]
    Unigene Representative Sequence: NM_013979
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231668(uc003mci.4 uc003mcj.4 uc003mck.4 uc003mcl.4)
    ENST00000351486(uc021yhw.1) ENST00000352523 ENST00000393770 ENST00000519459

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BNIP1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate BNIP1:
    hsa-miR-942 hsa-miR-1236
    SwitchGear 3'UTR luciferase reporter plasmidBNIP1 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for BNIP1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BNIP1
      QuantiTect SYBR Green Assays in human, mouse, rat BNIP1
      QuantiFast Probe-based Assays in human, mouse, rat BNIP1

    Additional mRNA sequence: 

    AF083956.1 AF083957.1 AF083958.1 AY216799.1 BC010959.1 U15172.1 

    8 DOTS entries:

    DT.442326  DT.95272174  DT.100744173  DT.75103276  DT.70101731  DT.120872366  DT.91765006  DT.120872275 

    Selected AceView cDNA sequences (see all 147):

    AI076673 BM479904 AL555935 CR611484 AA629095 CA431963 AA860860 AL558666 
    BM554627 BE894108 BU557084 AA405336 CR597535 AA677008 BC010959 CR619435 
    CA308951 BM975058 BM688689 BF222058 BM700585 BU850041 BF591660 Z38834 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BNIP1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                                                        -                     
    SP2:                          -                             -                     
    SP3:                                      -                 -                     
    SP4:                          -           -                 -                     
    SP5:                                                                              


    ECgene alternative splicing isoforms for BNIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BNIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BNIP1 Expression
    About this image


    BNIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    BNIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BNIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.145726

    UniProtKB/Swiss-Prot: SEC20_HUMAN, Q12981
    Tissue specificity: Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3
    is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine

        Pathway & Disease-focused RT2 Profiler PCR Array including BNIP1: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BNIP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bnip11 , 5 BCL2/adenovirus E1B interacting protein 11, 5 86.55(n)1
    93.86(a)1
      17 (13.56 cM)5
    2246301  NM_172149.51  NP_742161.41 
     267810795 
    chicken
    (Gallus gallus)
    Aves BNIP11 BCL2/adenovirus E1B 19kDa interacting protein 1 75.04(n)
    82.82(a)
      416207  XM_004944874.1  XP_004944931.1 
    lizard
    (Anolis carolinensis)
    Reptilia BNIP16
    BCL2/adenovirus E1B 19kDa interacting protein 1
    84(a)
    1 ↔ 1
    2(124563725-124576953)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC645392 hypothetical protein MGC64539 73.55(n)    BC054986.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.158802 Transcribed sequence with weak similarity to protein more 75.46(n)    BM534261.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG20231 CG2023 48.88(n)
    36.54(a)
      40724  NM_141338.3  NP_649595.1 


    ENSEMBL Gene Tree for BNIP1 (if available)
    TreeFam Gene Tree for BNIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BNIP1 (see all 462)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105466081,2
    C--167680946(+) TCATT-/A/A   
       A
    /AAA
    AAAAA
    4 -- int10--------
    rs1817746001,2
    --172569574(+) GTAGGC/TGCAAT 4 -- us2k10--------
    rs1432177551,2
    --172569577(+) GGCGCA/GATTGA 4 -- us2k10--------
    rs25445791,2
    C,F,A--172569844(-) agaaaG/CAAAGA 4 -- us2k1 trp310Minor allele frequency- C:0.34NA CSA WA EA 371
    rs2022387771,2
    C--172569855(+) TTTTTC/TTTTTT 4 -- us2k10--------
    rs113390951,2
    C--172569856(+) TTTTT-/TTTTTT 4 -- us2k1 trp31Minor allele frequency- T:0.00NA 2
    rs2021308531,2
    --172569858(+) TCTTT-/GTTTTT 4 -- us2k10--------
    rs134364401,2
    C--172569859(+) tctttG/Tttttt 4 -- us2k1 trp30--------
    rs1910286221,2
    --172569860(+) CTTTTC/TTTTTT 4 -- us2k10--------
    rs30958461,2
    C--172569962(-) GAATGG/ATGTGA 4 -- us2k16Minor allele frequency- A:0.00NA WA CSA 11

    HapMap Linkage Disequilibrium report for BNIP1 (172571445 - 172591390 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BNIP1: --
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603291    OMIM disorders: --

    1 disease for BNIP1:    
    About MalaCards
    spindle cell hemangioma

    1 disease from the University of Copenhagen DISEASES database for BNIP1:
    Spindle cell hemangioma

    Find genes that share disorders with BNIP1           About GenesLikeMe

    Genetic Association Database (GAD): BNIP1
    Human Genome Epidemiology (HuGE) Navigator: BNIP1 (1 document)

    Export disorders for BNIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BNIP1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with BNIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PubMed id 15272311)1, 2, 3 Nakajima K.... Tagaya M. (EMBO J. 2004)
    2. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. (PubMed id 7954800)1, 2, 3 Boyd J.M.... Chinnadurai G. (Cell 1994)
    3. Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis. (PubMed id 22306654)1, 4 Feenstra B....Melbye M. (Nat. Genet. 2012)
    4. RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. (PubMed id 21931693)1, 2 Tang F....Tang J. (PLoS ONE 2011)
    5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Novel BNIP1 variants and their interaction with BCL2 family members. (PubMed id 10217402)1, 2 Zhang H.... Meyhack B. (FEBS Lett. 1999)
    8. A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1. (PubMed id 23896122)1 Wang P....Tang J. (Cell. Signal. 2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Differential expression of BNIP family members of BH3-only proteins during the development and after axotomy in the rat. (PubMed id 22639046)1 Cho B....Geum D. (Mol. Cells 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 662 HGNC: 1082 AceView: BNIP1 Ensembl:ENSG00000113734 euGenes: HUgn662
    ECgene: BNIP1 Kegg: 662 H-InvDB: BNIP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BNIP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BNIP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/bnip1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BNIP1 gene:
    Search GeneIP for patents involving BNIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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