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Aliases for BNIP1 Gene

Aliases for BNIP1 Gene

  • BCL2/Adenovirus E1B 19kDa Interacting Protein 1 2 3
  • NIP1 3 4 6
  • BCL2/Adenovirus E1B 19 KDa Protein-Interacting Protein 1 3 4
  • Transformation-Related Gene 8 Protein 3 4
  • TRG-8 3 4
  • BCL2/Adenovirus E1B 19kD-Interacting Protein 1 2
  • Vesicle Transport Protein SEC20 3
  • SEC20L 4
  • SEC20 3

External Ids for BNIP1 Gene

Previous GeneCards Identifiers for BNIP1 Gene

  • GC05P172829
  • GC05P173273
  • GC05P172507
  • GC05P172552
  • GC05P172504
  • GC05P167665

Summaries for BNIP1 Gene

Entrez Gene Summary for BNIP1 Gene

  • This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011]

GeneCards Summary for BNIP1 Gene

BNIP1 (BCL2/Adenovirus E1B 19kDa Interacting Protein 1) is a Protein Coding gene. Diseases associated with BNIP1 include spindle cell hemangioma. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics.

UniProtKB/Swiss-Prot for BNIP1 Gene

  • SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNIP1 Gene

Genomics for BNIP1 Gene

Regulatory Elements for BNIP1 Gene

Genomic Location for BNIP1 Gene

Start:
173,144,442 bp from pter
End:
173,164,387 bp from pter
Size:
19,946 bases
Orientation:
Plus strand

Genomic View for BNIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BNIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNIP1 Gene

Proteins for BNIP1 Gene

  • Protein details for BNIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12981-SEC20_HUMAN
    Recommended name:
    Vesicle transport protein SEC20
    Protein Accession:
    Q12981
    Secondary Accessions:
    • D3DQM3
    • D3DQM4
    • D3DQM5
    • D3DQM6
    • O75622
    • O75623
    • O75624
    • Q6K044
    • Q96FG4

    Protein attributes for BNIP1 Gene

    Size:
    228 amino acids
    Molecular mass:
    26132 Da
    Quaternary structure:
    • Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2 and adenovirus E1B 19 kDa protein.
    Miscellaneous:
    • Silencing of BNIP1 disrupts ER morphology

    Alternative splice isoforms for BNIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BNIP1 Gene

Proteomics data for BNIP1 Gene at MOPED

Post-translational modifications for BNIP1 Gene

  • Lys-63-linked polyubiquitination by RNF185 allows recruiting of autophagy receptor SQSTM1, which simultaneously binds both ubiquitin and LC3 to link ubiquitination and autophagy.
  • Ubiquitination at Lys221
  • Modification sites at PhosphoSitePlus

Other Protein References for BNIP1 Gene

Antibody Products

No data available for DME Specific Peptides for BNIP1 Gene

Domains for BNIP1 Gene

Protein Domains for BNIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BNIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12981

UniProtKB/Swiss-Prot:

SEC20_HUMAN :
  • Q12981
Family:
  • Belongs to the SEC20 family.
genes like me logo Genes that share domains with BNIP1: view

No data available for Gene Families for BNIP1 Gene

Function for BNIP1 Gene

Molecular function for BNIP1 Gene

UniProtKB/Swiss-Prot Function:
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy.

Gene Ontology (GO) - Molecular Function for BNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IDA 15272311
GO:0005515 protein binding IPI 15272311
genes like me logo Genes that share ontologies with BNIP1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BNIP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BNIP1 Gene

Localization for BNIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BNIP1 Gene

Mitochondrion. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BNIP1 Gene COMPARTMENTS Subcellular localization image for BNIP1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytosol 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IDA 7954800
GO:0005737 cytoplasm IDA 7954800
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA 15272311
GO:0030176 integral component of endoplasmic reticulum membrane TAS 15272311
genes like me logo Genes that share ontologies with BNIP1: view

Pathways for BNIP1 Gene

genes like me logo Genes that share pathways with BNIP1: view

Pathways by source for BNIP1 Gene

1 KEGG pathway for BNIP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IPI 7954800
GO:0007029 endoplasmic reticulum organization IMP 15272311
GO:0016192 vesicle-mediated transport IEA --
GO:0016320 endoplasmic reticulum membrane fusion IMP 15272311
genes like me logo Genes that share ontologies with BNIP1: view

Transcripts for BNIP1 Gene

Unigene Clusters for BNIP1 Gene

BCL2/adenovirus E1B 19kDa interacting protein 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BNIP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BNIP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for BNIP1 Gene

GeneLoc Exon Structure for
BNIP1
ECgene alternative splicing isoforms for
BNIP1

Expression for BNIP1 Gene

mRNA expression in normal human tissues for BNIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for BNIP1 Gene

This gene is overexpressed in Cervix (17.2), Pancreas (7.8), and Bone (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BNIP1 Gene

SOURCE GeneReport for Unigene cluster for BNIP1 Gene Hs.145726

mRNA Expression by UniProt/SwissProt for BNIP1 Gene

Q12981-SEC20_HUMAN
Tissue specificity: Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.
genes like me logo Genes that share expressions with BNIP1: view

Expression partners for BNIP1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BNIP1 Gene

Orthologs for BNIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BNIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BNIP1 35
  • 89.62 (n)
  • 94.74 (a)
BNIP1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BNIP1 35
  • 91.81 (n)
  • 96.05 (a)
BNIP1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bnip1 35
  • 86.55 (n)
  • 93.86 (a)
Bnip1 16
Bnip1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BNIP1 35
  • 99.71 (n)
  • 100 (a)
BNIP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bnip1 35
  • 86.99 (n)
  • 95.18 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia BNIP1 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves BNIP1 35
  • 75.04 (n)
  • 82.82 (a)
BNIP1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BNIP1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bnip1 35
  • 71.07 (n)
  • 79.74 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64539 35
zebrafish
(Danio rerio)
Actinopterygii bnip1b 35
  • 71.2 (n)
  • 75 (a)
Dr.15880 35
bnip1a 36
  • 74 (a)
OneToMany
bnip1b 36
  • 74 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000242 35
  • 46.86 (n)
  • 34.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2023 35
  • 48.88 (n)
  • 36.54 (a)
CG2023 36
  • 31 (a)
OneToOne
Species with no ortholog for BNIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BNIP1 Gene

ENSEMBL:
Gene Tree for BNIP1 (if available)
TreeFam:
Gene Tree for BNIP1 (if available)

Paralogs for BNIP1 Gene

No data available for Paralogs for BNIP1 Gene

Variants for BNIP1 Gene

Sequence variations from dbSNP and Humsavar for BNIP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs8069 -- 173,164,153(+) CGAAC(C/T)GCCTC utr-variant-3-prime
rs8543 -- 173,164,334(+) TTCCT(G/T)GAATA utr-variant-3-prime
rs29794 -- 173,150,766(-) ATTTT(A/T)AAAAA intron-variant
rs29795 -- 173,150,400(-) ACATA(C/T)TGTTT intron-variant
rs29796 -- 173,149,233(-) cttcc(C/T)agtct intron-variant

Relevant External Links for BNIP1 Gene

HapMap Linkage Disequilibrium report
BNIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BNIP1 Gene

Disorders for BNIP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BNIP1 Gene in MalaCards »

(1) Diseases for BNIP1 Gene including...

(1) University of Copenhagen DISEASES for BNIP1 Gene

Relevant External Links for BNIP1

Genetic Association Database (GAD)
BNIP1
Human Genome Epidemiology (HuGE) Navigator
BNIP1
genes like me logo Genes that share disorders with BNIP1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for BNIP1 Gene

Publications for BNIP1 Gene

  1. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. (PMID: 7954800) Boyd J.M. … Chinnadurai G. (Cell 1994) 2 3 4
  2. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PMID: 15272311) Nakajima K. … Tagaya M. (EMBO J. 2004) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. (PMID: 21931693) Tang F. … Tang J. (PLoS ONE 2011) 3 4
  5. Common variants near MBNL1 and NKX2-5 are associated with infantile hypertrophic pyloric stenosis. (PMID: 22306654) Feenstra B. … Melbye M. (Nat. Genet. 2012) 3 48

Products for BNIP1 Gene

Sources for BNIP1 Gene

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