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BNC2 Gene

protein-coding   GIFtS: 53
GCID: GC09M016410

Basonuclin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Basonuclin 21 2
BSN22
Zinc Finger Protein Basonuclin-22

External Ids:    HGNC: 309881   Entrez Gene: 547962   Ensembl: ENSG000001730687   OMIM: 6086695   UniProtKB: Q6ZN303   

Export aliases for BNC2 gene to outside databases

Previous GC identifer: GC09U900603


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BNC2 Gene:
BNC2 (basonuclin 2) is a protein-coding gene. Diseases associated with BNC2 include barrett esophagus/esophageal adenocarcinoma, and urethritis. An important paralog of this gene is BNC1.

UniProtKB/Swiss-Prot: BNC2_HUMAN, Q6ZN30
Function: Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of
spermatozoa and oocytes

Gene Wiki entry for BNC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BNC2 gene promoter:
         RP58   Sox5   ISGF-3   FOXD3   Olf-1   Nkx2-5   Cdc5   RORalpha1   AREB6   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBNC2 promoter sequence
   Search Chromatin IP Primers for BNC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BNC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p22.2   Ensembl cytogenetic band:  9p22.2   HGNC cytogenetic band: 9p22.2

BNC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BNC2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M016410:  view genomic region     (about GC identifiers)

Start:
16,409,501 bp from pter      End:
16,870,841 bp from pter
Size:
461,341 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BNC2_HUMAN, Q6ZN30 (See protein sequence)
Recommended Name: Zinc finger protein basonuclin-2  
Size: 1099 amino acids; 122330 Da
Sequence caution: Sequence=AAR99389.1; Type=Erroneous initiation; Sequence=BAA90908.1; Type=Erroneous initiation;
Sequence=BAB15269.1; Type=Erroneous initiation; Sequence=BAC03837.1; Type=Erroneous initiation;
Secondary accessions: B1APG9 Q6T3A3 Q8NAR2 Q9H6J0 Q9NXV0
Alternative splicing: 2 isoforms:  Q6ZN30-1   Q6ZN30-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BNC2: NX_Q6ZN30

Explore proteomics data for BNC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BNC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060107.3  
    ENSEMBL proteins: 
     ENSP00000370047   ENSP00000431516   ENSP00000392212   ENSP00000408370   ENSP00000370042  
     ENSP00000474045   ENSP00000474647   ENSP00000473935   ENSP00000474468   ENSP00000474832  
     ENSP00000444640   ENSP00000370041  

    BNC2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for BNC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZN30

    ProtoNet protein and cluster: Q6ZN30

    UniProtKB/Swiss-Prot: BNC2_HUMAN, Q6ZN30
    Similarity: Contains 4 C2H2-type zinc fingers


    BNC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BNC2_HUMAN, Q6ZN30
    Function: Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of
    spermatozoa and oocytes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    BNC2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BNC2:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bnc2):
     craniofacial  digestive/alimentary  embryogenesis  growth/size/body  mortality/aging 
     skeleton 

    BNC2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BNC2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BNC2
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    miRNA
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    miRTarBase miRNAs that target BNC2:
    hsa-mir-26b-5p (MIRT029290), hsa-mir-16-5p (MIRT051162)

    Block miRNA regulation of human, mouse, rat BNC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BNC2 (see all 237):
    hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-106a hsa-miR-134 hsa-miR-3653 hsa-miR-3921 hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BNC2

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BNC2 (NM_017637)
    Sino Biological Human cDNA Clone for BNC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BNC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BNC2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BNC2_HUMAN, Q6ZN30: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    BNC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BNC2
    Interactions:

        Search GeneGlobe Interaction Network for BNC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for BNC2 (Q6ZN303 ENSP000003700474) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RB1P064003, ENSP000002671634I2D: score=2 STRING: ENSP00000267163
    IRF6O148963, ENSP000003559884I2D: score=1 STRING: ENSP00000355988
    SUMO2ENSP000004059654STRING: ENSP00000405965
    BMFENSP000003466974STRING: ENSP00000346697
    PMAIP1ENSP000003261194STRING: ENSP00000326119
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003416endochondral bone growth IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0043586tongue development IEA--
    GO:0060021palate development IEA--

    BNC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BNC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BNC2 gene: 
    NM_017637.5  

    Unigene Cluster for BNC2:

    Basonuclin 2
    Hs.656581  [show with all ESTs]
    Unigene Representative Sequence: NM_017637
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380672(uc003zmj.3 uc003zmk.3 uc003zmi.3 uc011lmv.2 uc003zml.3 uc011lmw.2)
    ENST00000484726(uc003zmm.3) ENST00000411752 ENST00000418777(uc003zmn.1)
    ENST00000380667 ENST00000603713 ENST00000486514 ENST00000603313 ENST00000468187(uc010mim.1)
    ENST00000471301(uc003zms.1 uc010mik.1) ENST00000545497 ENST00000380666(uc003zmo.1 uc003zmu.1 uc003zmq.1 uc003zmr.1 uc003zmp.1 uc010mij.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BNC2 (see all 237):
    hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-106a hsa-miR-134 hsa-miR-3653 hsa-miR-3921 hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BNC2
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    OriGene ORF clones in mouse, rat for BNC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BNC2 (NM_017637)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BNC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BNC2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for BNC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BNC2
      QuantiTect SYBR Green Assays in human, mouse, rat BNC2
      QuantiFast Probe-based Assays in human, mouse, rat BNC2

    Additional mRNA sequence: 

    AK000050.1 AK025882.1 AK092247.1 AK131398.1 AK299073.1 AK304745.1 AY438376.1 BC037160.2 
    BX641030.1 CR933649.1 DQ884933.1 DQ884934.1 DQ884935.1 DQ884938.1 DQ884939.1 DQ884940.1 
    DQ884941.1 DQ884944.1 DQ884945.1 DQ884946.1 DQ884947.1 DQ884948.1 

    12 DOTS entries:

    DT.208292  DT.95357026  DT.121156399  DT.101980797  DT.121156389  DT.121156424  DT.121156441  DT.121156476 
    DT.410692  DT.121156425  DT.40279500  DT.86847957 

    Selected AceView cDNA sequences (see all 73):

    AY438376 BX097723 AI950453 CB139726 BX281798 AI378475 BC037160 AW452878 
    AI868432 AA780150 NM_017637 AI377043 AA918922 AW188023 AI792819 AI374822 
    AI097383 AW137824 AI822010 AA236984 BU595577 CB268710 AK131398 AA442712 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BNC2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12
    SP1:                          -           -     -           -                       -     -         
    SP2:                          -                                                                     
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for BNC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BNC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTTGCCT
    BNC2 Expression
    About this image


    BNC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
     
     Gonad
             XY Germ Cells Testis Cord
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
    BNC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BNC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656581

    UniProtKB/Swiss-Prot: BNC2_HUMAN, Q6ZN30
    Tissue specificity: Highly expressed in testis, uterus and small intestine, and weakly expressed in colon and
    prostate. Also expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa and HEK293 cells.
    Not detected in blood, thymus, spleen or Hep-G2 cells

        Custom PCR Arrays for BNC2
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    QuantiFast Probe-based Assays in human, mouse, rat BNC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BNC2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bnc21 , 5 basonuclin 21, 5 90.91(n)1
    96.91(a)1
      4 (39.76 cM)5
    2425091  NM_172870.41  NP_766458.31 
     842750955 
    chicken
    (Gallus gallus)
    Aves BNC21 basonuclin 2 83.41(n)
    90.52(a)
      431604  XM_003642996.2  XP_003643044.2 
    lizard
    (Anolis carolinensis)
    Reptilia BNC26
    basonuclin 2
    62(a)
    1 ↔ 1
    2(35533072-35557313)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bnc21 basonuclin 2 76.94(n)
    82.61(a)
      100494907  XM_002935669.2  XP_002935715.2 
    zebrafish
    (Danio rerio)
    Actinopterygii bnc26
    basonuclin 2
    61(a)
    1 ↔ 1
    1(25990137-26175158) ENSDARG00000069989
    fruit fly
    (Drosophila melanogaster)
    Insecta disco6
    disco-r6
    disco-related
    25(a)
    13(a)
    many ↔ many
    many ↔ many
    X(16104631-16110779)
    X(16012821-16043010)
    worm
    (Caenorhabditis elegans)
    Secernentea F55C5.116
    Protein F55C5.11 (F55C5.11) mRNA, complete cds
    33(a)
    1 → many
    V(12275625-12277007) WBGene00044791


    ENSEMBL Gene Tree for BNC2 (if available)
    TreeFam Gene Tree for BNC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BNC2 gene
    BNC12  
    7 SIMAP similar genes for BNC2 using alignment to 22 protein entries:     BNC2_HUMAN (see all proteins):
    DKFZp686A01127    ZNF670    LRRC37A3    KIAA1651    DNAPTP3    BNC1
    RDX

    BNC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BNC2 (see all 11204)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs772334341,2
    C,F--16409053(+) CTGGTG/AGCTGC 1 -- ds50012Minor allele frequency- A:0.12WA EA 238
    rs736459701,2
    C,F--16409118(+) GCAAAG/AACACC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1869313941,2
    --16409245(+) GGGCAA/GTGTCT 1 -- ds50010--------
    rs1144870601,2
    C,F--16409262(+) CTCCAT/CTGGGA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1137610921,2
    C,F--16409322(+) GATGAG/CCTTGG 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs743786051,2
    F--16409432(+) GGCTGC/TTCGGT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1401545841,2
    --16409434(+) CTGCTC/TGGTGT 1 -- ds50010--------
    rs1421488391,2
    C--16409614(+) CTTATA/GCATTT 1 -- ut310--------
    rs759926481,2
    C,F--16409636(+) CATACT/CGTAGG 1 -- ut311Minor allele frequency- C:0.09WA 118
    rs1508679441,2
    --16409767(+) GTACAC/TACAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BNC2 (16409501 - 16659501 bp, first 250kb of BNC2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BNC2 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1378850CNV Deletion17803354
    esv2738238CNV Deletion23290073
    esv2738240CNV Deletion23290073
    esv2738241CNV Deletion23290073
    esv993349CNV Deletion20482838
    esv2675274CNV Deletion23128226
    esv1725129CNV Deletion17803354
    esv1256705CNV Insertion17803354
    esv267687CNV Insertion20981092
    esv273823CNV Insertion20981092

    Human Gene Mutation Database (HGMD): BNC2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BNC2
    DNA2.0 Custom Variant and Variant Library Synthesis for BNC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608669    OMIM disorders: --

    10 diseases for BNC2:    
    About MalaCards
    barrett esophagus/esophageal adenocarcinoma    urethritis    hypospadias    barrett's esophagus
    endometriosis    type 1 diabetes    esophagitis    ovarian cancer
    adenocarcinoma    prostatitis


    BNC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BNC2
    Human Genome Epidemiology (HuGE) Navigator: BNC2 (9 documents)

    Export disorders for BNC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BNC2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with BNC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Basonuclin 2: an extremely conserved homolog of the zinc finger protein basonuclin. (PubMed id 14988505)1, 2, 9 Vanhoutteghem A. and Djian P. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PubMed id 20852632)1, 4 Goode E.L....Pharoah P.D. (Nat. Genet. 2010)
    4. Web-based, participant-driven studies yield novel genetic associations for common traits. (PubMed id 20585627)1, 4 Eriksson N....Mountain J. (PLoS Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)1, 4 Paterson A.D....Bull S.B. (Diabetes 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. (PubMed id 19648919)1, 4 Song H....Gayther S.A. (Nat. Genet. 2009)
    9. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    10. Identification of Basonuclin2, a DNA-binding zinc-finger protein expressed in germ tissues and skin keratinocytes. (PubMed id 15081112)1, 2 Romano R.-A.... Sinha S. (Genomics 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54796 HGNC: 30988 AceView: BNC2 Ensembl:ENSG00000173068 euGenes: HUgn54796
    ECgene: BNC2 H-InvDB: BNC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BNC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BNC2 gene:
    Search GeneIP for patents involving BNC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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