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BNC1 Gene

protein-coding   GIFtS: 48
GCID: GC15M083924

Basonuclin 1

(Previous name: basonuclin)
(Previous symbol: BNC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Basonuclin 11 2     HsT194472
BNC1 2 3     Zinc Finger Protein Basonuclin2
basonuclin1     Zinc Finger Protein Basonuclin-12
BSN12     

External Ids:    HGNC: 10811   Entrez Gene: 6462   Ensembl: ENSG000001695947   OMIM: 6019305   UniProtKB: Q019543   

Export aliases for BNC1 gene to outside databases

Previous GC identifers: GC15M081645 GC15M081715 GC15M060188


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BNC1 Gene:
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in
hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to
play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This
gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known
yet. There seems to be evidence of multiple polyadenylation sites for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for BNC1 Gene:
BNC1 (basonuclin 1) is a protein-coding gene. Diseases associated with BNC1 include bladder neck obstruction, and cystitis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is BNC2.

UniProtKB/Swiss-Prot: BNC1_HUMAN, Q01954
Function: Likely to be a transcription factor specific for squamous epithelium and for the constituent
keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. May play a role in
the differentiation of spermatozoa and oocytes

Gene Wiki entry for BNC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BNC1 gene promoter:
         NF-1   p53   Pbx1a   ATF-2   CUTL1   AP-2gamma   E47   CREB   CRE-BP1   c-Rel   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BNC1 promoter sequence
   Search Chromatin IP Primers for BNC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BNC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.2   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q25.1

BNC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BNC1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M083924:  view genomic region     (about GC identifiers)

Start:
83,924,655 bp from pter      End:
83,953,468 bp from pter
Size:
28,814 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BNC1_HUMAN, Q01954 (See protein sequence)
Recommended Name: Zinc finger protein basonuclin-1  
Size: 994 amino acids; 110972 Da
Secondary accessions: Q15840

Explore the universe of human proteins at neXtProt for BNC1: NX_Q01954

Explore proteomics data for BNC1 at MOPED

Post-translational modifications: 

  • Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BNC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001708.3  
    ENSEMBL proteins: 
     ENSP00000307041   ENSP00000456727  

    BNC1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for BNC1
    Cloud-Clone Corp. CLIAs for BNC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q01954

    ProtoNet protein and cluster: Q01954

    UniProtKB/Swiss-Prot: BNC1_HUMAN, Q01954
    Similarity: Contains 6 C2H2-type zinc fingers


    BNC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BNC1_HUMAN, Q01954
    Function: Likely to be a transcription factor specific for squamous epithelium and for the constituent
    keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. May play a role in
    the differentiation of spermatozoa and oocytes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9099851
    GO:0046872metal ion binding IEA--
         
    BNC1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bnc1):
     homeostasis/metabolism  no phenotypic analysis  vision/eye 

    BNC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bnc1tm1.1Tsen for BNC1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BNC1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BNC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BNC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target BNC1:
    hsa-mir-26b-5p (MIRT029748), hsa-mir-335-5p (MIRT018429)

    Block miRNA regulation of human, mouse, rat BNC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BNC1 (see all 34):
    hsa-miR-302d hsa-miR-520e hsa-miR-376b hsa-miR-300 hsa-miR-146a hsa-miR-30d hsa-miR-519a hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidBNC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BNC1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: BNC1 (NM_001717)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BNC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BNC1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for BNC1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BNC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BNC1_HUMAN, Q01954: Nucleus (By similarity). Cytoplasm (By similarity). Note=Relocates to the midpiece of the
    flagellum during late spermiogenesis in spermatids (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    BNC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BNC1
    Interactions:

        Search GeneGlobe Interaction Network for BNC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for BNC1 (Q019543 ENSP000003070414) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PICK1Q9NRD53, ENSP000003494654I2D: score=1 STRING: ENSP00000349465
    BIDP559573, ENSP000003188224I2D: score=1 STRING: ENSP00000318822
    BIKQ133233, ENSP000002161154I2D: score=1 STRING: ENSP00000216115
    HRKO001983, ENSP000002575724I2D: score=1 STRING: ENSP00000257572
    BMFQ96LC93, ENSP000003466974I2D: score=1 STRING: ENSP00000346697
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006356regulation of transcription from RNA polymerase I promoter IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0008284positive regulation of cell proliferation TAS8034748
    GO:0008544epidermis development TAS1332044

    BNC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BNC1

    2 Novoseek inferred chemical compound relationships for BNC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 65.3 22 14988505 (2), 1332044 (2), 10462520 (2), 9727087 (2) (see all 12)
    serine 33.3 4 9223293 (2), 1332044 (1)



    BNC1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BNC1 gene: 
    NM_001717.3  

    Unigene Cluster for BNC1:

    Basonuclin 1
    Hs.459153  [show with all ESTs]
    Unigene Representative Sequence: L03427
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000345382(uc010uos.1 uc002bjt.1) ENST00000569704
    miRNA
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    Block miRNA regulation of human, mouse, rat BNC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BNC1 (see all 34):
    hsa-miR-302d hsa-miR-520e hsa-miR-376b hsa-miR-300 hsa-miR-146a hsa-miR-30d hsa-miR-519a hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidBNC1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BNC1
    Predesigned siRNA for gene silencing in human, mouse, rat BNC1
    Clone
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    OriGene ORF clones in mouse, rat for BNC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BNC1 (NM_001717)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BNC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BNC1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for BNC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BNC1
      QuantiTect SYBR Green Assays in human, mouse, rat BNC1
      QuantiFast Probe-based Assays in human, mouse, rat BNC1

    Additional mRNA sequence: 

    AK302992.1 L03427.1 

    2 DOTS entries:

    DT.209924  DT.121048238 

    Selected AceView cDNA sequences (see all 28):

    BX106012 AI921950 T29840 AL039315 AL045814 AL044452 AA978112 AL044568 
    AL705195 BQ317057 CB151626 AW274655 BI060631 BG676748 NM_001717 AI376578 
    AL042263 L03427 AI247348 AA994036 CA313840 CN478777 AI027965 R25330 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BNC1 expression in normal human tissues (normalized intensities)      BNC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGAAAGGA
    BNC1 Expression
    About this image


    BNC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Bulge Stem Cells Bulge
             Hair Follicle
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Respiratory Bronchioles
     
     Bone (Muscoskeletal System)
             Mandibular Process
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
    BNC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BNC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459153

    UniProtKB/Swiss-Prot: BNC1_HUMAN, Q01954
    Tissue specificity: Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary
    glands, placenta, brain and heart

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BNC1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bnc11 , 5 basonuclin 11, 5 86.67(n)1
    87.15(a)1
      7 (45.71 cM)5
    121731  NM_007562.21  NP_031588.21 
     819666725 
    chicken
    (Gallus gallus)
    Aves BNC11 basonuclin 1 70.14(n)
    69.27(a)
      427504  XM_004943823.1  XP_004943880.1 
    lizard
    (Anolis carolinensis)
    Reptilia BNC16
    basonuclin 1
    58(a)
    1 ↔ 1
    GL343836.1(51152-82614)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.124162 Transcribed sequence with moderate similarity to protein more 74.01(n)    BX709667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5687861 zinc finger protein basonuclin-1-like 63.57(n)
    61.66(a)
      568786  XM_692139.5  XP_697231.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta disco6
    disco-r6
    disco-related
    21(a)
    12(a)
    many ↔ many
    many ↔ many
    X(16104631-16110779)
    X(16012821-16043010)
    worm
    (Caenorhabditis elegans)
    Secernentea F55C5.116
    Protein F55C5.11 (F55C5.11) mRNA, complete cds
    31(a)
    1 → many
    V(12275625-12277007) WBGene00044791


    ENSEMBL Gene Tree for BNC1 (if available)
    TreeFam Gene Tree for BNC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BNC1 gene
    BNC22  
    2 SIMAP similar genes for BNC1 using alignment to 2 protein entries:     BNC1_HUMAN (see all proteins):
    BNC2    DKFZp686A01127

    BNC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BNC1 (see all 574)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496877031,2
    Cuntested183932427(+) CATTTC/TGTTTG 2 K E mis11Minor allele frequency- T:0.00NA 4552
    rs1908538261,2
    --83924270(+) GTTTGA/GCCATG 1 -- ds50010--------
    rs286270411,2
    C--83924320(+) TGCCCA/GCCTTG 1 -- ds50010--------
    rs43891081,2
    C,F--83924335(+) CCCAAG/AGTGCT 1 -- ds50015Minor allele frequency- A:0.14NA WA EA 128
    rs1143738821,2
    F--83924348(+) GATTAC/TGGGCA 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1809678341,2
    C--83924594(+) CACTTC/GTACAA 1 -- ds50010--------
    rs1849880261,2
    --83924640(+) GTTTGC/TCTTTT 1 -- ds50010--------
    rs787049471,2
    C,F--83924708(+) TCTTTT/CCACTT 1 -- ut311Minor allele frequency- C:0.13WA 118
    rs1901880221,2
    --83924865(+) TTAGAA/CCACAG 1 -- ut310--------
    rs1824160711,2
    --83924878(+) ATAATC/GTCTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BNC1 (83924655 - 83953468 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BNC1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BNC1
    DNA2.0 Custom Variant and Variant Library Synthesis for BNC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601930    OMIM disorders: --

    8 diseases for BNC1:    About MalaCards
    bladder neck obstruction    cystitis    basal cell carcinoma    bronchiolitis
    lymphoblastic leukemia    gingivitis    leukemia    endotheliitis


    BNC1 for disorders           About GeneDecksing


    Export disorders for BNC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BNC1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with BNC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Basonuclin: a keratinocyte protein with multiple paired zinc fingers. (PubMed id 1332044)1, 2, 3, 9 Tseng H. and Green H. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylation. (PubMed id 9223293)1, 2, 9 Iuchi S. and Green H. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis. (PubMed id 9687312)1, 2, 9 Mahoney M.G.... Tseng H. (Biol. Reprod. 1998)
    4. The human basonuclin gene. (PubMed id 9099851)1, 2, 9 Teumer J.... Green H. (Gene 1997)
    5. Alternative subcellular locations of keratinocyte basonuclin. (PubMed id 10839715)1, 9 Iuchi S....Green H. (Exp. Dermatol. 2000)
    6. An unexpected localization of basonuclin in the centrosome, mitochondria, and acrosome of developing spermatids. (PubMed id 9151672)1, 9 Yang Z....Fuchs E. (J. Cell Biol. 1997)
    7. Basonuclin is associated with the ribosomal RNA genes on human keratinocyte mitotic chromosomes. (PubMed id 10462520)1, 9 Tseng H....Brown R.S. (J. Cell. Sci. 1999)
    8. Basonuclin, a zinc finger protein associated with epithelial expansion and proliferation. (PubMed id 9727087)1, 9 Tseng H. (Front. Biosci. 1998)
    9. Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter. (PubMed id 10449744)1, 9 Iuchi S. and Green H. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    10. Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation. (PubMed id 8034748)1, 9 Tseng H. and Green H. (J. Cell Biol. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 646 HGNC: 1081 AceView: BNC1 Ensembl:ENSG00000169594 euGenes: HUgn646
    ECgene: BNC1 H-InvDB: BNC1

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BNC1 Pharmacogenomics, SNPs, Pathways

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    Patent Information for BNC1 gene:
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