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Aliases for BNC1 Gene

Aliases for BNC1 Gene

  • Basonuclin 1 2 3 5
  • BNC 3 4
  • Zinc Finger Protein Basonuclin-1 3
  • Basonuclin 2
  • HsT19447 3
  • BSN1 3

External Ids for BNC1 Gene

Previous HGNC Symbols for BNC1 Gene

  • BNC

Previous GeneCards Identifiers for BNC1 Gene

  • GC15M081645
  • GC15M081715
  • GC15M083924
  • GC15M060188

Summaries for BNC1 Gene

Entrez Gene Summary for BNC1 Gene

  • The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Alternative splicing of this gene results in multiple transcript variants, and multiple polyadenylation sites are indicated.[provided by RefSeq, Jul 2014]

GeneCards Summary for BNC1 Gene

BNC1 (Basonuclin 1) is a Protein Coding gene. Diseases associated with BNC1 include Subdural Empyema. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is BNC2.

UniProtKB/Swiss-Prot for BNC1 Gene

  • Transcriptional activator (By similarity). Likely specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). May also play a role in the differentiation of oocytes and the early development of embryos (By similarity).

Gene Wiki entry for BNC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNC1 Gene

Genomics for BNC1 Gene

Regulatory Elements for BNC1 Gene

Enhancers for BNC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F083277 1.5 FANTOM5 Ensembl ENCODE 21.9 +0.9 948 12.4 HDGF PKNOX1 CBX5 SCRT2 RCOR1 FOS CREM EGR2 CBFB CEBPB BNC1 BTBD1 HDGFRP3 GOLGA6L9 AP3B2 FAM103A1 HOMER2 UBE2Q2P2 LOC105370932
GH15F083377 1.4 FANTOM5 Ensembl ENCODE 17 -94.4 -94442 3.9 HDGF CTCF ZNF146 PKNOX1 TAF1 JUN CEBPG ZIC2 RAD21 ZKSCAN1 BNC1 C15orf40 FAM103A1 GOLGA6L9 LOC105370934 SH3GL3
GH15F083364 1 Ensembl ENCODE 20.7 -80.8 -80785 1.4 CTCF PKNOX1 RAD21 E2F1 ZFHX2 CTBP1 SMC3 PRDM10 RCOR1 ZNF600 BNC1 LOC105370934 LOC105370933
GH15F083320 1.3 FANTOM5 Ensembl ENCODE 15.1 -38.0 -38012 5.2 CTCF MAX SIN3A ZNF384 RAD21 POLR2A CBX5 EED FOS CREM BNC1 HOMER2 C15orf40 BTBD1 LOC105370933
GH15F083304 1 Ensembl ENCODE 11.9 -20.9 -20943 2.2 CTCF MAZ PKNOX1 TRIM22 SIN3A CEBPB MNT RAD21 ZFHX2 CEBPA BNC1 BTBD1 LOC105370933
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BNC1 on UCSC Golden Path with GeneCards custom track

Promoters for BNC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000412543 1015 2600 SUZ12 L3MBTL2 RNF2 CBX2 ZFP69B GATA3 SMARCA4 ZNF692 ZBTB26 PRDM1

Genomic Location for BNC1 Gene

Chromosome:
15
Start:
83,255,884 bp from pter
End:
83,284,716 bp from pter
Size:
28,833 bases
Orientation:
Minus strand

Genomic View for BNC1 Gene

Genes around BNC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BNC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BNC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNC1 Gene

Proteins for BNC1 Gene

  • Protein details for BNC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01954-BNC1_HUMAN
    Recommended name:
    Zinc finger protein basonuclin-1
    Protein Accession:
    Q01954
    Secondary Accessions:
    • Q15840

    Protein attributes for BNC1 Gene

    Size:
    994 amino acids
    Molecular mass:
    110972 Da
    Quaternary structure:
    • Interacts with HSF2BP (via C-terminus).

neXtProt entry for BNC1 Gene

Post-translational modifications for BNC1 Gene

  • Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BNC1 Gene

No data available for DME Specific Peptides for BNC1 Gene

Domains & Families for BNC1 Gene

Gene Families for BNC1 Gene

Protein Domains for BNC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BNC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01954

UniProtKB/Swiss-Prot:

BNC1_HUMAN :
  • Contains 6 C2H2-type zinc fingers.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with BNC1: view

Function for BNC1 Gene

Molecular function for BNC1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator (By similarity). Likely specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). May also play a role in the differentiation of oocytes and the early development of embryos (By similarity).

Gene Ontology (GO) - Molecular Function for BNC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9099851
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with BNC1: view
genes like me logo Genes that share phenotypes with BNC1: view

Animal Models for BNC1 Gene

MGI Knock Outs for BNC1:

Animal Model Products

miRNA for BNC1 Gene

miRTarBase miRNAs that target BNC1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BNC1 Gene

Localization for BNC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BNC1 Gene

Nucleus. Cytoplasm. Nucleus, nucleoplasm. Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids. {ECO:0000250 UniProtKB:O35914}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BNC1 gene
Compartment Confidence
nucleus 5
cytosol 2
endosome 1

Gene Ontology (GO) - Cellular Components for BNC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8034748
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BNC1: view

Pathways & Interactions for BNC1 Gene

No Data Available

Interacting Proteins for BNC1 Gene

Gene Ontology (GO) - Biological Process for BNC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007283 spermatogenesis IEA --
GO:0008284 positive regulation of cell proliferation TAS 8034748
GO:0008544 epidermis development TAS 1332044
genes like me logo Genes that share ontologies with BNC1: view

No data available for Pathways by source and SIGNOR curated interactions for BNC1 Gene

Drugs & Compounds for BNC1 Gene

(2) Drugs for BNC1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with BNC1: view

Transcripts for BNC1 Gene

mRNA/cDNA for BNC1 Gene

Unigene Clusters for BNC1 Gene

Basonuclin 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BNC1 Gene

No ASD Table

Relevant External Links for BNC1 Gene

GeneLoc Exon Structure for
BNC1
ECgene alternative splicing isoforms for
BNC1

Expression for BNC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BNC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BNC1 Gene

This gene is overexpressed in Testis (x8.2), Esophagus - Mucosa (x8.1), Adipose - Visceral (Omentum) (x7.1), Skin - Not Sun Exposed (Suprapubic) (x5.3), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for BNC1 Gene

This gene is overexpressed in Plasma (59.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BNC1 Gene



Protein tissue co-expression partners for BNC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of BNC1 Gene:

BNC1

SOURCE GeneReport for Unigene cluster for BNC1 Gene:

Hs.459153

mRNA Expression by UniProt/SwissProt for BNC1 Gene:

Q01954-BNC1_HUMAN
Tissue specificity: In epidermis, primarily detected in cells of the basal or immediately suprabasal layers (at protein level) (PubMed:16891417). In hair follicles, mainly expressed in the outer root sheath (at protein level) (PubMed:8034748). Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart (PubMed:9687312).
genes like me logo Genes that share expression patterns with BNC1: view

Primer Products

Orthologs for BNC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BNC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BNC1 34 35
  • 99.7 (n)
mouse
(Mus musculus)
Mammalia Bnc1 34 16 35
  • 86.67 (n)
rat
(Rattus norvegicus)
Mammalia Bnc1 34
  • 86.63 (n)
dog
(Canis familiaris)
Mammalia BNC1 34 35
  • 85.43 (n)
cow
(Bos Taurus)
Mammalia BNC1 34 35
  • 82.8 (n)
oppossum
(Monodelphis domestica)
Mammalia BNC1 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BNC1 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves BNC1 34 35
  • 70.14 (n)
lizard
(Anolis carolinensis)
Reptilia BNC1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bnc1 34
  • 62.94 (n)
Str.12416 34
zebrafish
(Danio rerio)
Actinopterygii LOC568786 34
  • 63.57 (n)
BNC1 35
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta disco 35
  • 21 (a)
ManyToMany
disco-r 35
  • 12 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F55C5.11 35
  • 31 (a)
OneToMany
Species where no ortholog for BNC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BNC1 Gene

ENSEMBL:
Gene Tree for BNC1 (if available)
TreeFam:
Gene Tree for BNC1 (if available)

Paralogs for BNC1 Gene

Paralogs for BNC1 Gene

(2) SIMAP similar genes for BNC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BNC1: view

Variants for BNC1 Gene

Sequence variations from dbSNP and Humsavar for BNC1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs111544127 -- 83,267,453(+) TGAGC(A/G)TTAGT intron-variant, upstream-variant-2KB
rs111591968 -- 83,283,441(+) CGGCT(C/T)CCAGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs111633086 -- 83,257,374(+) AACAT(C/T)TCTAT utr-variant-3-prime
rs111819383 -- 83,284,614(+) CTCGG(A/C)GGGCG intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs112345306 -- 83,274,354(+) CACTC(C/T)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BNC1 Gene

Variant ID Type Subtype PubMed ID
nsv474536 CNV novel sequence insertion 20440878
nsv1120052 OTHER inversion 24896259
dgv1257n106 CNV deletion 24896259

Variation tolerance for BNC1 Gene

Residual Variation Intolerance Score: 5.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BNC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BNC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BNC1 Gene

Disorders for BNC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BNC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
subdural empyema
  • subdural abscess
- elite association - COSMIC cancer census association via MalaCards
Search BNC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BNC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BNC1
genes like me logo Genes that share disorders with BNC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BNC1 Gene

Publications for BNC1 Gene

  1. Basonuclin: a keratinocyte protein with multiple paired zinc fingers. (PMID: 1332044) Tseng H. … Green H. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 22 64
  2. Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions. (PMID: 16891417) Vanhoutteghem A. … Djian P. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 22 64
  3. Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis. (PMID: 9687312) Mahoney M.G. … Tseng H. (Biol. Reprod. 1998) 3 4 22 64
  4. The human basonuclin gene. (PMID: 9099851) Teumer J. … Green H. (Gene 1997) 3 4 22 64
  5. Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylation. (PMID: 9223293) Iuchi S. … Green H. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 22 64

Products for BNC1 Gene

Sources for BNC1 Gene

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