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Aliases for BNC1 Gene

Aliases for BNC1 Gene

  • Basonuclin 1 2 3 5
  • BNC 3 4
  • Basonuclin 2
  • HsT19447 3
  • BSN1 3

External Ids for BNC1 Gene

Previous HGNC Symbols for BNC1 Gene

  • BNC

Previous GeneCards Identifiers for BNC1 Gene

  • GC15M081645
  • GC15M081715
  • GC15M083924
  • GC15M060188

Summaries for BNC1 Gene

Entrez Gene Summary for BNC1 Gene

  • The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Alternative splicing of this gene results in multiple transcript variants, and multiple polyadenylation sites are indicated.[provided by RefSeq, Jul 2014]

GeneCards Summary for BNC1 Gene

BNC1 (Basonuclin 1) is a Protein Coding gene. Diseases associated with BNC1 include subdural empyema. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is BNC2.

UniProtKB/Swiss-Prot for BNC1 Gene

  • Likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. May play a role in the differentiation of spermatozoa and oocytes.

Gene Wiki entry for BNC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BNC1 Gene

Genomics for BNC1 Gene

Regulatory Elements for BNC1 Gene

Promoters for BNC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BNC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BNC1 Gene

Chromosome:
15
Start:
83,255,884 bp from pter
End:
83,284,716 bp from pter
Size:
28,833 bases
Orientation:
Minus strand

Genomic View for BNC1 Gene

Genes around BNC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BNC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BNC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BNC1 Gene

Proteins for BNC1 Gene

  • Protein details for BNC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01954-BNC1_HUMAN
    Recommended name:
    Zinc finger protein basonuclin-1
    Protein Accession:
    Q01954
    Secondary Accessions:
    • Q15840

    Protein attributes for BNC1 Gene

    Size:
    994 amino acids
    Molecular mass:
    110972 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BNC1 Gene

Proteomics data for BNC1 Gene at MOPED

Post-translational modifications for BNC1 Gene

  • Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BNC1 Gene

No data available for DME Specific Peptides for BNC1 Gene

Domains & Families for BNC1 Gene

Gene Families for BNC1 Gene

Protein Domains for BNC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BNC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01954

UniProtKB/Swiss-Prot:

BNC1_HUMAN :
  • Contains 6 C2H2-type zinc fingers.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with BNC1: view

Function for BNC1 Gene

Molecular function for BNC1 Gene

UniProtKB/Swiss-Prot Function:
Likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. May play a role in the differentiation of spermatozoa and oocytes.
genes like me logo Genes that share phenotypes with BNC1: view

Animal Models for BNC1 Gene

MGI Knock Outs for BNC1:

Animal Model Products

miRNA for BNC1 Gene

miRTarBase miRNAs that target BNC1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BNC1 Gene

Localization for BNC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BNC1 Gene

Nucleus. Cytoplasm. Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BNC1 Gene COMPARTMENTS Subcellular localization image for BNC1 gene
Compartment Confidence
nucleus 5
cytosol 2
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for BNC1 Gene

Pathways & Interactions for BNC1 Gene

SuperPathways for BNC1 Gene

No Data Available

Interacting Proteins for BNC1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000307041%0d%0a9606.ENSP00000349465%0d%0a9606.ENSP00000291560%0d%0a
Selected Interacting proteins: Q01954-BNC1_HUMAN ENSP00000307041 for BNC1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for BNC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation TAS 8034748
genes like me logo Genes that share ontologies with BNC1: view

No data available for Pathways by source and SIGNOR curated interactions for BNC1 Gene

Drugs & Compounds for BNC1 Gene

(2) Drugs for BNC1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with BNC1: view

Transcripts for BNC1 Gene

Unigene Clusters for BNC1 Gene

Basonuclin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BNC1 Gene

No ASD Table

Relevant External Links for BNC1 Gene

GeneLoc Exon Structure for
BNC1
ECgene alternative splicing isoforms for
BNC1

Expression for BNC1 Gene

mRNA expression in normal human tissues for BNC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BNC1 Gene

This gene is overexpressed in Testis (x8.2), Esophagus - Mucosa (x8.1), Adipose - Visceral (Omentum) (x7.1), Skin - Not Sun Exposed (Suprapubic) (x5.3), and Skin - Sun Exposed (Lower leg) (x4.5).

Protein differential expression in normal tissues from HIPED for BNC1 Gene

This gene is overexpressed in Plasma (59.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BNC1 Gene



SOURCE GeneReport for Unigene cluster for BNC1 Gene Hs.459153

mRNA Expression by UniProt/SwissProt for BNC1 Gene

Q01954-BNC1_HUMAN
Tissue specificity: Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart.
genes like me logo Genes that share expression patterns with BNC1: view

Protein tissue co-expression partners for BNC1 Gene

Primer Products

In Situ Assay Products

Orthologs for BNC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BNC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BNC1 35
  • 82.8 (n)
  • 83.66 (a)
BNC1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BNC1 35
  • 85.43 (n)
  • 86.71 (a)
BNC1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bnc1 35
  • 86.67 (n)
  • 87.15 (a)
Bnc1 16
Bnc1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BNC1 35
  • 99.7 (n)
  • 99.59 (a)
BNC1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bnc1 35
  • 86.63 (n)
  • 86.93 (a)
oppossum
(Monodelphis domestica)
Mammalia BNC1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BNC1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves BNC1 35
  • 70.14 (n)
  • 69.27 (a)
BNC1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BNC1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bnc1 35
  • 62.94 (n)
  • 60.82 (a)
Str.12416 35
zebrafish
(Danio rerio)
Actinopterygii LOC568786 35
  • 63.57 (n)
  • 61.66 (a)
BNC1 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta disco 36
  • 21 (a)
ManyToMany
disco-r 36
  • 12 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F55C5.11 36
  • 31 (a)
OneToMany
Species with no ortholog for BNC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BNC1 Gene

ENSEMBL:
Gene Tree for BNC1 (if available)
TreeFam:
Gene Tree for BNC1 (if available)

Paralogs for BNC1 Gene

Paralogs for BNC1 Gene

(2) SIMAP similar genes for BNC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BNC1: view

Variants for BNC1 Gene

Sequence variations from dbSNP and Humsavar for BNC1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1130108 -- 83,264,401(-) GGCCC(A/C/T)TCCCT reference, missense
rs1130109 -- 83,264,400(-) GCCCT(A/T)CCCTG reference, missense
rs4389108 -- 83,255,583(+) CCCAA(A/G)GTGCT downstream-variant-500B
rs4408505 -- 83,259,039(+) GTAAC(A/G)TTTCA intron-variant
rs4423388 -- 83,261,734(+) CCTGC(A/G)TGTGT intron-variant

Variation tolerance for BNC1 Gene

Residual Variation Intolerance Score: 5.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BNC1 Gene

HapMap Linkage Disequilibrium report
BNC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BNC1 Gene

Disorders for BNC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BNC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
subdural empyema
  • subdural abscess
- elite association - COSMIC cancer census association via MalaCards
Search BNC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BNC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BNC1
genes like me logo Genes that share disorders with BNC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BNC1 Gene

Publications for BNC1 Gene

  1. Basonuclin: a keratinocyte protein with multiple paired zinc fingers. (PMID: 1332044) Tseng H. … Green H. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23 67
  2. Epigenetic analysis of childhood acute lymphoblastic leukemia. (PMID: 19430199) Dunwell T.L. … Latif F. (Epigenetics 2009) 3 23
  3. Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions. (PMID: 16891417) Vanhoutteghem A. … Djian P. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 23
  4. Alternative subcellular locations of keratinocyte basonuclin. (PMID: 10839715) Iuchi S. … Green H. (Exp. Dermatol. 2000) 3 23
  5. Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter. (PMID: 10449744) Iuchi S. … Green H. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 23

Products for BNC1 Gene

Sources for BNC1 Gene

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