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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BMX Gene

protein-coding   GIFtS: 68
GCID: GC0XP015392

BMX non-receptor tyrosine kinase
 Explore 14 diseases affiliated with
BMX via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BMX    

Aliases
for BMX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
BMX Non-Receptor Tyrosine Kinase1 2     PSCTK22
ETK1 2 3     Cytoplasmic Tyrosine-Protein Kinase BMX2
PSCTK31 2     Etk/Bmx Cytosolic Tyrosine Kinase2
Bone Marrow Tyrosine Kinase Gene In Chromosome X Protein2 3     NTK38 Tyrosine Kinase2
Epithelial And Endothelial Tyrosine Kinase2 3     NTK383
EC 2.7.10.23 8     EC 2.7.108

External Ids:    HGNC: 10791   Entrez Gene: 6602   Ensembl: ENSG000001020107   OMIM: 3001015   UniProtKB: P518133   

Export aliases for BMX gene to outside databases

Previous GC identifers: GC0XP015192 GC0XP014308 GC0XP014684 GC0XP014886 GC0XP014880 GC0XP015242 GC0XP013280


Summaries
for BMX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BMX:
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like
domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2
domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated
in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity
of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been
identified.(provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: BMX_HUMAN, P51813
Function: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes
involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion,
and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors,
G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to
integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling
events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced
angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for
angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell
differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming
adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain
endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with
an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as
in signal transduction in endocardial and arterial endothelial cells

Gene Wiki entry for BMX


Genomic Views
for BMX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMX gene promoter:
         HTF   COMP1   STAT3   POU2F1c   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BMX promoter sequence
   Search SABiosciences Chromatin IP Primers for BMX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.2

BMX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP015392:  view genomic region     (about GC identifiers)

Start:
 15,482,369 bp from pter      End:
 15,574,652 bp from pter
Size:
 92,284 bases      Orientation:
 plus strand

Proteins
for BMX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BMX_HUMAN, P51813 (See protein sequence)
Recommended Name: Cytoplasmic tyrosine-protein kinase BMX  
Size: 675 amino acids; 78011 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with BCAR1, CAV1, MYD88, PTK2/FAK1, RUFY1, RUFY2, STAT3, TIRAP and TNFRSF1B
Subcellular location: Cytoplasm. Note=Localizes to the edges of spreading cells when complexed with BCAR1
Sequence caution: Sequence=AAC08966.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for BMX:
2EKX (3D)        2YS2 (3D)        3SXR (3D)        3SXS (3D)    
Secondary accessions: A6NIH9 O60564 Q12871

Explore the universe of human proteins at neXtProt for BMX: NX_P51813

Post-translational modifications:

  • Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis leads to
    • activation and is required for STAT3 phosphorylation by BMX1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51813

    • 4/7 DME Specific Peptides for BMX (P51813) (see all 7)
     PIYIVTE  LSYYEYD  RDLAARN  VKFYGVC 

    BMX Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001712.1  NP_975010.1  

    ENSEMBL proteins: 
     ENSP00000350224   ENSP00000308774   ENSP00000340082  
    Reactome Protein details: P51813
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant BMX Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): BMX
    OriGene Protein Over-expression Lysate (see all 3): BMX
    OriGene Custom Protein Services for BMX 
    GenScript Custom Purified and Recombinant Proteins Services for BMX
    Novus Biologicals BMX Proteins
    Novus Biologicals BMX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BMX

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0032587ruffle membrane IDA11331870


    BMX for ontologies           About GeneDecksing



    BMX Antibody Products: 
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    Cell Signaling Technology (CST) Antibodies for BMX  (Etk)
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    Novus Biologicals BMX Antibodies
    Abcam antibodies for BMX 
    Uscn Antibodies for BMX
    ThermoFisher Antibodies for BMX

    Assay Products for BMX: 
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    Uscn ELISAs and CLIAs for BMX

    Protein Domains /
    Families
    for BMX gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BMX for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR001849 Pleckstrin_homology
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P51813

    ProtoNet protein and cluster: P51813

    4 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: BMX_HUMAN, P51813
    Domain: SH2 domain mediates interaction with RUFY1
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain


    Function
    for BMX gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BMX_HUMAN, P51813
    Function: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes
    involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion,
    and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors,
    G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to
    integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling
    events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced
    angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for
    angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell
    differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming
    adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain
    endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with
    an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as
    in signal transduction in endocardial and arterial endothelial cells
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: TEK and vascular endothelial growth factor receptor 1 (FLT1) stimulate BMX tyrosine kinase activity
    (By similarity). Activated by integrins through the mediation of PTK2/FAK1. Activated by TNF through the mediation of
    TNFRSF1B
    Induction: Activated by IL6/interleukin-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that
    activation occurs through binding of phosphoinositides to the PH domain

         Genatlas biochemistry entry for BMX:
    bone marrow tyrosine kinase,X-linked,involved in growth and differentiation of hematopoietic cells,SRC family,Tec
    subfamily

    Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): BMX
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMX
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate BMX:
    hsa-miR-466 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: BMX 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMX (see all 7)
    OriGene shRNA RFP: BMX
    OriGene siRNA: BMX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMX

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BMX

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMX (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMX (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): BMX (NM_203281)
    Sino Biological Human cDNA Clone for BMX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMX 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for BMX
    Search LifeMap BioReagents cell lines for BMX

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMX

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity TAS7970727
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA11331870
    GO:0004871signal transducer activity TAS9520419
    GO:0005515protein binding IPI16186805
    GO:0005524ATP binding IEA--


    BMX for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for BMX:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)  

    Animal Models:
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Bmx):
     immune system  normal  skeleton 

    BMX for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BMX gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic cleavage of cellular proteins
    		Apoptotic cleavage of cellular proteins1.00
    		Apoptotic execution phase0.73
    2G-protein signaling_RhoA regulation pathway
    		G-protein signaling RhoA regulation pathway1.00
    		G-protein signaling_RhoA regulation pathway1.00
    3Tyrosine Kinases / Adaptors
    		Tyrosine Kinases / Adaptors1.00
    4Lymphocyte Signaling
    		Lymphocyte Signaling1.00
    5IL-3 Signaling Pathway
    		IL-3 Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for BMX
        G-protein signaling RhoA regulation pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BMX
        Tec Kinases Signaling
    Transendothelial Migration of Leukocytes

    2 Cell Signaling Technology (CST) Pathways for BMX
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for BMX
        G-protein signaling RhoA regulation pathway

    4 BioSystems Pathways for BMX 
        IL-6 Signaling Pathway
    IL-3 Signaling Pathway
    Signaling events mediated by focal adhesion kinase
    Angiopoietin receptor Tie2-mediated signaling

    3        Reactome Pathways for BMX
        Apoptotic execution phase
    Apoptotic cleavage of cellular proteins
    Apoptosis



    BMX for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BMX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for BMX (P518131, 2, 3 ENSP000003087744) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIM1P113091, 2, 3, ENSP000003626084EBI-696657,EBI-696621 MINT-68562 MINT-68561 MINT-68560 MINT-68563 I2D: score=2 STRING: ENSP00000362608
    ERBB2P046262, 3, ENSP000002695714MINT-74488 I2D: score=2 STRING: ENSP00000269571
    TP53P046372, 3, ENSP000002693054MINT-68565 I2D: score=2 STRING: ENSP00000269305
    GAB1Q134802, 3, ENSP000002629954MINT-68564 I2D: score=1 STRING: ENSP00000262995
    EGFRP005332, 3, ENSP000002754934MINT-74487 I2D: score=2 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS7970727
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0006950response to stress IEA--
    GO:0007155cell adhesion IEA--


    BMX for ontologies           About GeneDecksing



    Drugs & Compounds
    for BMX gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BMX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BMX

    2 HMDB Compounds for BMX    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    6 Novoseek chemical compound relationships for BMX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 74.3 72 7970727 (4), 10688651 (3), 9323053 (3), 8790141 (2) (see all 44)
    phosphatidylinositol 54.5 15 17823122 (5), 9520419 (2), 10608894 (1), 11382770 (1) (see all 6)
    ly294002 28.8 1 10362360 (1)
    vegf 22.1 16 12483534 (4), 14532277 (3), 15788485 (3), 18402776 (2)
    calcium 0 1 10224128 (1)
    estrogen 0 5 10608894 (1), 14676838 (1)

    Search CenterWatch for drugs/clinical trials and news about BMX 

    Transcripts
    for BMX gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BMX gene (2 alternative transcripts): 
    NM_001721.6  NM_203281.2  

    Unigene Cluster for BMX:

    BMX non-receptor tyrosine kinase
    Hs.495731  [show with all ESTs]
    Unigene Representative Sequence: AF045459
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357607(uc004cww.3) ENST00000348343(uc004cwx.4) ENST00000466843
    ENST00000463891 ENST00000342014(uc004cwy.4) ENST00000489983

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMX
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    hsa-miR-466 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmid: BMX 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMX
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): BMX (NM_203281)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMX

    Additional cDNA sequence: 

    AF045459.1 AK291824.1 AK313568.1 BC016652.2 U08341.1 X83107.1 

    4 DOTS entries:

    DT.97771039  DT.95363327  DT.100741067  DT.97839797 

    24/33 AceView cDNA sequences (see all 33):

    NM_001721 Z40071 BQ229686 AI677766 NM_203281 CB998198 AI500626 BE896015 
    BM804905 BM544910 BU172565 X83107 AF045459 F02760 AA297618 BQ226991 
    F06972 F06481 BC016652 AI382692 BQ878627 AW512350 BQ350352 AA303367 

    GeneLoc Exon Structure


    Expression
    for BMX gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BMX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTAAAGACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BMX expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BMX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BMX

    SOURCE GeneReport for Unigene cluster: Hs.495731

    UniProtKB/Swiss-Prot: BMX_HUMAN, P51813
    Tissue specificity: Highly expressed in cells with great migratory potential, including endothelial cells and
    metastatic carcinoma cell lines

        SABiosciences Custom PCR Arrays for BMX
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMX
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMX
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMX

    Orthologs
    for BMX gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BMX gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BMX1 BMX non-receptor tyrosine kinase 69.75(n)
    67.99(a)    		   428003  XM_425573.3  XP_425573.3 
    lizard
    (Anolis carolinensis)    		 Reptilia BMX6
    		 --
    		 63(a)
    		 1 ↔ 1
    		 3(121473638-121500386)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Btk29A3 male genital morphogenesis (sensu
    Holometabola) more    		 52(a)   29A1   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G047006
    AT1G162706
    (see all 7)    		 PB1 domain-containing protein tyrosine kinase
    octicosapeptide/Phox/Be.1 domain-containing protei...
    (see all 7)    		 9(a)
    9(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 1(1316254-1320919)
    1(5563087-5568368)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 protein kinase domain containing protein, expresse...
    protein kinase domain containing protein, expresse...
    (see all 5)    		 9(a)
    8(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 7(14722116-14730584)
    2(33380337-33387027)


    ENSEMBL Gene Tree for BMX (if available)
    TreeFam Gene Tree for BMX (if available) 

    Paralogs
    for BMX gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BMX gene
    TEC2  FRK2  LCK2  BLK2  FGR2  ITK2  LYN2  TXK2  
    HCK2  YES12  PTK62  SRC2  ABL12  FYN2  ABL22  SRMS2  
    BTK2  
    18/23 SIMAP similar genes for BMX using alignment to 1 protein entry:     BMX_HUMAN(see all similar genes):
    BTK kinase deficient isoform 2    TEC    EPHA2    FYN    ABL2    ITK
    BLK    CSK    FRK    LYN    TXK    YES1
    SRC    MATK    PRKAA1    PTK6    BCR/ABL fusion    SRMS

    BMX for paralogs           About GeneDecksing



    Genomic Variants
    for BMX gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/645 NCBI SNPs in BMX are shown (see all 645)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs65276161,2
    		C,F,A,H,--15516974(+) AGCAGA/GTTGCC 1 -- us2k126Minor allele frequency- G:0.79NS EA NA WA CSA 2458
    rs1122205251,2
    		C,--15517381(+) GGGAAT/CTGCCC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1826151181,2
    		--15517560(+) CATATC/TACCAA 1 -- us2k10--------
    rs1852339571,2
    		--15517591(+) AGTTTA/GCTTTT 1 -- us2k10--------
    rs1113750671,2
    		C,--15517657(+) AAATCA/GCCATG 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs169970631,2
    		C,F,H,--15517692(+) GTGTAA/GAATTA 1 -- us2k18Minor allele frequency- G:0.92NA NS 934
    rs2014668871,2
    		--15517921(+) TCTGC-/AAGTTA 1 -- us2k10--------
    rs38347001,2
    		C--15517969(+) CCCCC-/CACACA 1 -- us2k1 trp30--------
    rs736351001,2
    		C,--15517979(+) CCCCCA/CCACAC 1 -- us2k11Minor allele frequency- C:0.00WA 2
    rs1833940401,2
    		--15517986(+) ACACAC/GACACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BMX (15482369 - 15574652 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BMX: --
    Locus Specific Mutation Databases (LSDB): BMX

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    Disorders / Diseases
    for BMX gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BMX for disorders           About GeneDecksing

    OMIM gene information: 300101    OMIM disorders: --

    14 diseases for BMX:    About MalaCards
    agammaglobulinemia    prostate cancer    breast cancer    noma
    hepatocellular carcinoma    prostatitis    nasopharyngitis    prostate carcinoma
    lung cancer    carcinoma    ischemia    glioblastoma
    arthritis    leukemia

    1 disease from the University of Copenhagen DISEASES database for BMX:
    Agammaglobulinemia

    6 Novoseek disease relationships for BMX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    x-linked agammaglobulinemia 81.9 1 7970727 (1)
    prostate cancer 39.5 30 16912182 (5), 15355990 (2), 9520419 (2), 14981536 (2) (see all 6)
    necrosis 7.71 4 14532277 (2), 12370298 (1)
    tumors 0.533 10 14532277 (2), 18196928 (2), 12370298 (1), 18413754 (1) (see all 5)
    breast cancer 0 1 11382770 (1)
    cancer 0 4 11382770 (2), 16276002 (1)

    Human Genome Epidemiology (HuGE) Navigator: BMX (3 documents)

    Export disorders for BMX gene to outside databases

    Publications
    for BMX gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BMX gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with BMX)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. (PubMed id 7970727)1, 2, 3, 9 Tamagnone L.... Alitalo K. (1994)
    2. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. (PubMed id 10688651)1, 2, 9 Tsai Y.T....Chen R.H. (2000)
    3. Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis. (PubMed id 12370298)1, 2, 9 Pan S....Min W. (2002)
    4. Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. (PubMed id 9520419)1, 2, 9 Qiu Y.... Kung H.-J. (1998)
    5. Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. (PubMed id 11331870)1, 2, 9 Chen R....Qiu Y. (2001)
    6. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. (PubMed id 18292575)1, 2, 9 Semaan N....Sibilia J. (2008)
    7. Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx. (PubMed id 11751885)1, 2, 9 Vargas L....Mohamed A.J. (2002)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases. (PubMed id 12573241)1, 2 Nore B.F....Smith C.I. (2003)
    10. Interaction between tyrosine kinase Etk and a RUN-domain and FYVE- domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking. (PubMed id 11877430)1, 2 Yang J.... Qiu Y. (2002)

    External Searches for BMX gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BMX gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 660 HGNC: 1079 AceView: BMX Ensembl:ENSG00000102010 euGenes: HUgn660
    ECgene: BMX H-InvDB: BMX

    Other Databases showing BMX gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BMX gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BMX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMX Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for BMX gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BMX gene:
    Search GeneIP for patents involving BMX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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