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BMX Gene

protein-coding   GIFtS: 69
GCID: GC0XP015392

BMX Non-Receptor Tyrosine Kinase

  See BMX-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BMX Non-Receptor Tyrosine Kinase1 2     PSCTK32
BTK-Like On X Chromosome1 2     Cytoplasmic Tyrosine-Protein Kinase BMX2
Bone Marrow Tyrosine Kinase Gene In Chromosome X Protein2 3     Etk/Bmx Cytosolic Tyrosine Kinase2
Epithelial And Endothelial Tyrosine Kinase2 3     NTK38 Tyrosine Kinase2
ETK2 3     NTK383
EC 2.7.10.23 8     EC 2.7.108
PSCTK22     

External Ids:    HGNC: 10791   Entrez Gene: 6602   Ensembl: ENSG000001020107   OMIM: 3001015   UniProtKB: P518133   

Export aliases for BMX gene to outside databases

Previous GC identifers: GC0XP015192 GC0XP014308 GC0XP014684 GC0XP014886 GC0XP014880 GC0XP015242 GC0XP013280


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BMX Gene:
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a
PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3),
and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein
is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation
and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same
protein, have been identified.(provided by RefSeq, Sep 2009)

GeneCards Summary for BMX Gene:
BMX (BMX non-receptor tyrosine kinase) is a protein-coding gene. Diseases associated with BMX include prostate cancer. GO annotations related to this gene include phospholipid binding and protein tyrosine kinase activity. An important paralog of this gene is TEC.

UniProtKB/Swiss-Prot: BMX_HUMAN, P51813
Function: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling
processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival,
cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine
receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of
BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator
of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical
role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor
families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription
factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also
a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary
epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis
through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation
of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells

Gene Wiki entry for BMX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BMX gene promoter:
         HTF   COMP1   STAT3   POU2F1c   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMX promoter sequence
   Search Chromatin IP Primers for BMX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.2

BMX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP015392:  view genomic region     (about GC identifiers)

Start:
15,482,369 bp from pter      End:
15,574,652 bp from pter
Size:
92,284 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BMX_HUMAN, P51813 (See protein sequence)
Recommended Name: Cytoplasmic tyrosine-protein kinase BMX  
Size: 675 amino acids; 78011 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with BCAR1, CAV1, MYD88, PTK2/FAK1, RUFY1, RUFY2, STAT3, TIRAP and TNFRSF1B
Sequence caution: Sequence=AAC08966.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for BMX:
2EKX (3D)        2YS2 (3D)        3SXR (3D)        3SXS (3D)    
Secondary accessions: A6NIH9 O60564 Q12871

Explore the universe of human proteins at neXtProt for BMX: NX_P51813

Explore proteomics data for BMX at MOPED

Post-translational modifications: 

  • Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis
    leads to activation and is required for STAT3 phosphorylation by BMX1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for BMX (P51813) (see all 7)
     PIYIVTE  LSYYEYD  RDLAARN  VKFYGVC 


    See BMX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001712.1  NP_975010.1  

    ENSEMBL proteins: 
     ENSP00000350224   ENSP00000308774   ENSP00000340082  
    Reactome Protein details: P51813

    BMX Human Recombinant Protein Products:

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    BMX Antibody Products:

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    Search eBioscience for ELISAs for BMX 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: BMX non-receptor tyrosine kinase
    Tec family

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001849 Pleckstrin_homology
     IPR000719 Prot_kinase_dom
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry P51813

    ProtoNet protein and cluster: P51813

    4 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: BMX_HUMAN, P51813
    Domain: SH2 domain mediates interaction with RUFY1
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with BMX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMX_HUMAN, P51813
    Function: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling
    processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival,
    cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine
    receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of
    BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator
    of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical
    role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor
    families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription
    factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also
    a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary
    epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis
    through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation
    of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: TEK and vascular endothelial growth factor receptor 1 (FLT1) stimulate BMX tyrosine kinase
    activity (By similarity). Activated by integrins through the mediation of PTK2/FAK1. Activated by TNF through the
    mediation of TNFRSF1B
    Induction: Activated by IL6/interleukin-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely
    that activation occurs through binding of phosphoinositides to the PH domain

         Genatlas biochemistry entry for BMX:
    bone marrow tyrosine kinase,X-linked,involved in growth and differentiation of hematopoietic cells,SRC family,Tec
    subfamily

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS7970727
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA10688651
    GO:0004871signal transducer activity TAS9520419
    GO:0005515protein binding IPI10688651
         
    Find genes that share ontologies with BMX           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BMX:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)  

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bmx):
     immune system  normal  skeleton 

    Find genes that share phenotypes with BMX           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BMX
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BMX
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate BMX:
    hsa-miR-466 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidBMX 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BMX
    Predesigned siRNA for gene silencing in human, mouse, rat BMX

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): BMX (NM_203281)
    Sino Biological Human cDNA Clone for BMX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMX
    Addgene plasmids for BMX 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BMX_HUMAN, P51813: Cytoplasm. Note=Localizes to the edges of spreading cells when complexed with BCAR1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0032587ruffle membrane IDA11331870

    Find genes that share ontologies with BMX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BMX About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic cleavage of cellular proteins
    Apoptotic cleavage of cellular proteins0.74
    Apoptotic execution phase0.74
    2Akt Signaling
    Tec Kinases Signaling0.55
    3CDK-mediated phosphorylation and removal of Cdc6
    Apoptosis0.38
    4Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    5Immune response IL 23 signaling pathway
    Angiopoietin receptor Tie2-mediated signaling0.32


    Find genes that share SuperPaths with BMX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BMX
        Tec Kinases Signaling
    Transendothelial Migration of Leukocytes

    2 Cell Signaling Technology (CST) Pathways for BMX
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for BMX
        G-protein signaling RhoA regulation pathway

    4 BioSystems Pathways for BMX
        IL-6 Signaling Pathway
    IL-3 Signaling Pathway
    Angiopoietin receptor Tie2-mediated signaling
    Signaling events mediated by focal adhesion kinase


    1 Reactome Pathway for BMX
        Apoptotic cleavage of cellular proteins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BMX
    Interactions:

        GeneGlobe Interaction Network for BMX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BMX (P518131, 2, 3 ENSP000003087744) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIM1P113091, 2, 3, ENSP000003626084EBI-696657,EBI-696621 MINT-68562 MINT-68561 MINT-68560 MINT-68563 I2D: score=2 STRING: ENSP00000362608
    ERBB2P046262, 3, ENSP000002695714MINT-74488 I2D: score=2 STRING: ENSP00000269571
    TP53P046372, 3, ENSP000002693054MINT-68565 I2D: score=2 STRING: ENSP00000269305
    GAB1Q134802, 3, ENSP000002629954MINT-68564 I2D: score=1 STRING: ENSP00000262995
    EGFRP005332, 3, ENSP000002754934MINT-74487 I2D: score=2 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS7970727
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0006950response to stress IEA--
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with BMX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BMX

    2 HMDB Compounds for BMX    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 Novoseek inferred chemical compound relationships for BMX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 74.3 72 7970727 (4), 10688651 (3), 9323053 (3), 8790141 (2) (see all 44)
    phosphatidylinositol 54.5 15 17823122 (5), 9520419 (2), 10608894 (1), 11382770 (1) (see all 6)
    ly294002 28.8 1 10362360 (1)
    vegf 22.1 16 12483534 (4), 14532277 (3), 15788485 (3), 18402776 (2)
    calcium 0 1 10224128 (1)
    estrogen 0 5 10608894 (1), 14676838 (1)



    Find genes that share compounds with BMX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BMX gene (2 alternative transcripts): 
    NM_001721.6  NM_203281.2  

    Unigene Cluster for BMX:

    BMX non-receptor tyrosine kinase
    Hs.495731  [show with all ESTs]
    Unigene Representative Sequence: AF045459
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357607(uc004cww.3) ENST00000348343(uc004cwx.4) ENST00000463891
    ENST00000342014(uc004cwy.4) ENST00000489983
    miRNA
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    hsa-miR-466 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidBMX 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat BMX
      QuantiFast Probe-based Assays in human, mouse, rat BMX

    Additional mRNA sequence: 

    AF045459.1 AK291824.1 AK313568.1 BC016652.2 U08341.1 X83107.1 

    4 DOTS entries:

    DT.97771039  DT.95363327  DT.100741067  DT.97839797 

    Selected AceView cDNA sequences (see all 33):

    AI677766 Z40071 NM_001721 BQ229686 NM_203281 BQ878627 F06972 AI500626 
    AA297618 F02760 CB998198 BE896015 BU172565 BC016652 F06481 BM544910 
    BQ226991 AI382692 X83107 BM804905 AF045459 AA303367 BQ350352 AW512350 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BMX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAAGACT
    BMX Expression
    About this image


    BMX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    BMX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BMX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495731

    UniProtKB/Swiss-Prot: BMX_HUMAN, P51813
    Tissue specificity: Highly expressed in cells with great migratory potential, including endothelial cells and
    metastatic carcinoma cell lines

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    QuantiFast Probe-based Assays in human, mouse, rat BMX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BMX gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmx1 , 5 BMX non-receptor tyrosine kinase1, 5 88.75(n)1
    90.6(a)1
      X (76.12 cM)5
    121691  NM_009759.41  NP_033889.21 
     1641928425 
    chicken
    (Gallus gallus)
    Aves BMX1 BMX non-receptor tyrosine kinase 69.8(n)
    67.62(a)
      428003  XM_425573.4  XP_425573.3 
    lizard
    (Anolis carolinensis)
    Reptilia BMX6
    BMX non-receptor tyrosine kinase
    63(a)
    1 ↔ 1
    3(121473638-121500386)
    fruit fly
    (Drosophila melanogaster)
    Insecta Btk29A3 male genital morphogenesis (sensu
    Holometabola) more
    52(a)   29A1   --


    ENSEMBL Gene Tree for BMX (if available)
    TreeFam Gene Tree for BMX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BMX gene
    TEC2  CSK2  FER2  ITK2  TXK2  FES2  DSTYK2  MATK2  
    BTK2  
    Selected SIMAP similar genes for BMX using alignment to 1 protein entry:     BMX_HUMAN(see all similar genes):
    BTK kinase deficient isoform 2    TEC    EPHA2    FYN    ABL2    ITK
    BLK    CSK    FRK    LYN    TXK    YES1
    SRC    MATK    PRKAA1    PTK6    BCR/ABL fusion    SRMS

    Find genes that share paralogs with BMX           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BMX (see all 778)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0416754
    A lung large cell carcinoma sample4--see VAR_0416752 R W mis40--------
    rs65276161,2
    C,F,A,H--15432052(+) AGCAGA/GTTGCC 1 -- us2k126Minor allele frequency- G:0.79NS EA NA WA CSA 2458
    rs1826151181,2
    --15432638(+) CATATC/TACCAA 1 -- us2k10--------
    rs1852339571,2
    --15432669(+) AGTTTA/GCTTTT 1 -- us2k10--------
    rs1113750671,2
    C,F--15432735(+) AAATCA/GCCATG 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs169970631,2
    C,F,H--15432770(+) GTGTAA/GAATTA 1 -- us2k18Minor allele frequency- G:0.92NA NS 934
    rs2014668871,2
    C--15432999(+) TCTGC-/AAGTTA 1 -- us2k10--------
    rs38347001,2
    C--15433047(+) TGGTT-/C/CCCC
            
    CCCCC
    1 -- us2k1 trp31CSA 2
    rs113361681,2
    C--15433057(+) CCCCCA/CCACAC 1 -- us2k1 trp31Minor allele frequency- C:0.00WA 2
    rs1833940401,2
    C--15433064(+) ACACAC/GACACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BMX (15482369 - 15574652 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BMX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510526CNV Loss20534489

    Locus Specific Mutation Databases (LSDB): BMX

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BMX
    DNA2.0 Custom Variant and Variant Library Synthesis for BMX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300101    OMIM disorders: --

    1 disease for BMX:    
    About MalaCards
    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for BMX:
    Agammaglobulinemia

    Find genes that share disorders with BMX           About GenesLikeMe

    6 Novoseek inferred disease relationships for BMX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    x-linked agammaglobulinemia 81.9 1 7970727 (1)
    prostate cancer 39.5 30 16912182 (5), 15355990 (2), 9520419 (2), 14981536 (2) (see all 6)
    necrosis 7.71 4 14532277 (2), 12370298 (1)
    tumors 0.533 10 14532277 (2), 18196928 (2), 12370298 (1), 18413754 (1) (see all 5)
    breast cancer 0 1 11382770 (1)
    cancer 0 4 11382770 (2), 16276002 (1)

    Genetic Association Database (GAD): BMX
    Human Genome Epidemiology (HuGE) Navigator: BMX (3 documents)

    Export disorders for BMX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BMX gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with BMX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. (PubMed id 7970727)1, 2, 3, 9 Tamagnone L.... Alitalo K. (Oncogene 1994)
    2. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. (PubMed id 10688651)1, 2, 9 Tsai Y.T.... Chen R.H. (Mol. Cell. Biol. 2000)
    3. Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis. (PubMed id 12370298)1, 2, 9 Pan S.... Min W. (Mol. Cell. Biol. 2002)
    4. Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. (PubMed id 9520419)1, 2, 9 Qiu Y.... Kung H.-J. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    5. Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. (PubMed id 11331870)1, 2, 9 Chen R.... Qiu Y. (Nat. Cell Biol. 2001)
    6. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. (PubMed id 18292575)1, 2, 9 Semaan N.... Sibilia J. (J. Immunol. 2008)
    7. Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx. (PubMed id 11751885)1, 2, 9 Vargas L.... Mohamed A.J. (J. Biol. Chem. 2002)
    8. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    9. A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PubMed id 19464057)1, 4 Kreil S....Chase A. (Leuk. Res. 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 660 HGNC: 1079 AceView: BMX Ensembl:ENSG00000102010 euGenes: HUgn660
    ECgene: BMX H-InvDB: BMX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BMX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BMX gene:
    Search GeneIP for patents involving BMX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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