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Aliases for BMX Gene

Aliases for BMX Gene

  • BMX Non-Receptor Tyrosine Kinase 2 3
  • Bone Marrow Tyrosine Kinase Gene In Chromosome X Protein 3 4
  • Epithelial And Endothelial Tyrosine Kinase 3 4
  • BTK-Like On X Chromosome 2 3
  • EC 2.7.10.2 4 63
  • ETK 3 4
  • Cytoplasmic Tyrosine-Protein Kinase BMX 3
  • Etk/Bmx Cytosolic Tyrosine Kinase 3
  • NTK38 Tyrosine Kinase 3
  • EC 2.7.10 63
  • PSCTK2 3
  • PSCTK3 3
  • NTK38 4

External Ids for BMX Gene

Previous GeneCards Identifiers for BMX Gene

  • GC0XP015192
  • GC0XP014308
  • GC0XP014684
  • GC0XP014886
  • GC0XP014880
  • GC0XP015242
  • GC0XP013280

Summaries for BMX Gene

Entrez Gene Summary for BMX Gene

  • This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]

GeneCards Summary for BMX Gene

BMX (BMX Non-Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with BMX include prostate cancer. Among its related pathways are Akt Signaling and Tyrosine Kinases / Adaptors. GO annotations related to this gene include phospholipid binding and protein tyrosine kinase activity. An important paralog of this gene is FER.

UniProtKB/Swiss-Prot for BMX Gene

  • Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.

Gene Wiki entry for BMX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMX Gene

Genomics for BMX Gene

Regulatory Elements for BMX Gene

Genomic Location for BMX Gene

Start:
15,464,246 bp from pter
End:
15,556,529 bp from pter
Size:
92,284 bases
Orientation:
Plus strand

Genomic View for BMX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMX Gene

Proteins for BMX Gene

  • Protein details for BMX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51813-BMX_HUMAN
    Recommended name:
    Cytoplasmic tyrosine-protein kinase BMX
    Protein Accession:
    P51813
    Secondary Accessions:
    • A6NIH9
    • O60564
    • Q12871

    Protein attributes for BMX Gene

    Size:
    675 amino acids
    Molecular mass:
    78011 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with BCAR1, CAV1, MYD88, PTK2/FAK1, RUFY1, RUFY2, STAT3, TIRAP and TNFRSF1B.
    SequenceCaution:
    • Sequence=AAC08966.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BMX Gene

neXtProt entry for BMX Gene

Proteomics data for BMX Gene at MOPED

Selected DME Specific Peptides for BMX Gene

Post-translational modifications for BMX Gene

  • Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis leads to activation and is required for STAT3 phosphorylation by BMX.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BMX Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BMX (Etk)

Domains for BMX Gene

Gene Families for BMX Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SH2D :SH2 domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for BMX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51813

UniProtKB/Swiss-Prot:

BMX_HUMAN :
  • P51813
Domain:
  • SH2 domain mediates interaction with RUFY1.
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Similarity:
  • Contains 1 Btk-type zinc finger.
genes like me logo Genes that share domains with BMX: view

Function for BMX Gene

Molecular function for BMX Gene

GENATLAS Biochemistry:
bone marrow tyrosine kinase,X-linked,involved in growth and differentiation of hematopoietic cells,SRC family,Tec subfamily
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
TEK and vascular endothelial growth factor receptor 1 (FLT1) stimulate BMX tyrosine kinase activity (By similarity). Activated by integrins through the mediation of PTK2/FAK1. Activated by TNF through the mediation of TNFRSF1B.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
UniProtKB/Swiss-Prot Induction:
Activated by IL6/interleukin-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain.

Enzyme Numbers (IUBMB) for BMX Gene

Gene Ontology (GO) - Molecular Function for BMX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS 7970727
GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA 10688651
GO:0004871 signal transducer activity TAS 9520419
GO:0005102 NOT receptor binding IBA --
genes like me logo Genes that share ontologies with BMX: view
genes like me logo Genes that share phenotypes with BMX: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMX

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BMX Gene

Localization for BMX Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMX Gene

Cytoplasm. Note=Localizes to the edges of spreading cells when complexed with BCAR1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BMX Gene COMPARTMENTS Subcellular localization image for BMX gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for BMX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
GO:0032587 ruffle membrane IDA 11331870
genes like me logo Genes that share ontologies with BMX: view

Pathways for BMX Gene

genes like me logo Genes that share pathways with BMX: view

Pathways by source for BMX Gene

Gene Ontology (GO) - Biological Process for BMX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0006468 protein phosphorylation TAS 7970727
GO:0006915 apoptotic process TAS --
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
GO:0006950 response to stress --
genes like me logo Genes that share ontologies with BMX: view

Compounds for BMX Gene

(2) HMDB Compounds for BMX Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(6) Novoseek inferred chemical compound relationships for BMX Gene

Compound -log(P) Hits PubMed IDs
tyrosine 74.3 62
phosphatidylinositol 54.5 11
ly294002 28.8 1
vegf 22.1 12
calcium 0 1
genes like me logo Genes that share compounds with BMX: view

Transcripts for BMX Gene

Unigene Clusters for BMX Gene

BMX non-receptor tyrosine kinase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMX

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BMX Gene

No ASD Table

Relevant External Links for BMX Gene

GeneLoc Exon Structure for
BMX
ECgene alternative splicing isoforms for
BMX

Expression for BMX Gene

mRNA expression in normal human tissues for BMX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BMX Gene

This gene is overexpressed in Whole Blood (16.8) and Heart - Atrial Appendage (4.6).

Protein differential expression in normal tissues for BMX Gene

This gene is overexpressed in Cerebrospinal fluid (41.2) and Pancreatic juice (27.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BMX Gene

SOURCE GeneReport for Unigene cluster for BMX Gene Hs.495731

mRNA Expression by UniProt/SwissProt for BMX Gene

P51813-BMX_HUMAN
Tissue specificity: Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines
genes like me logo Genes that share expressions with BMX: view

In Situ Assay Products

Orthologs for BMX Gene

This gene was present in the common ancestor of animals.

Orthologs for BMX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BMX 35
  • 92.24 (n)
  • 93.37 (a)
BMX 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BMX 35
  • 89.73 (n)
  • 92.45 (a)
BMX 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bmx 35
  • 88.75 (n)
  • 90.6 (a)
Bmx 16
Bmx 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BMX 35
  • 93.88 (n)
  • 92.97 (a)
BMX 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bmx 35
  • 87.88 (n)
  • 90.29 (a)
oppossum
(Monodelphis domestica)
Mammalia BMX 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BMX 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves BMX 35
  • 69.8 (n)
  • 67.62 (a)
BMX 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BMX 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Btk29A 37
  • 52 (a)
Btk29A 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C25A8.5 37
  • 31 (a)
F22B3.8 37
  • 31 (a)
F23C8.7 37
  • 30 (a)
F26E4.5 37
  • 33 (a)
F59A3.8 37
  • 28 (a)
kin-24 37
  • 25 (a)
R05H5.4 37
  • 31 (a)
spe-8 37
  • 32 (a)
T14E8.1a 37
  • 34 (a)
T14E8.1b 37
  • 34 (a)
T25B9.4 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
ManyToMany
Species with no ortholog for BMX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for BMX Gene

ENSEMBL:
Gene Tree for BMX (if available)
TreeFam:
Gene Tree for BMX (if available)

Paralogs for BMX Gene

Paralogs for BMX Gene

Selected SIMAP similar genes for BMX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BMX: view

Variants for BMX Gene

Sequence variations from dbSNP and Humsavar for BMX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs233566 -- 15,505,607(+) TGCAT(A/G)TGAAT upstream-variant-2KB, intron-variant
rs233567 -- 15,544,039(+) GAGGG(C/T)AAGTA intron-variant
rs233568 -- 15,546,343(+) AGCCA(C/T)TAAAC intron-variant
rs233569 -- 15,546,631(+) ATTAT(C/T)TTTTA intron-variant
rs233570 -- 15,548,485(+) AATCA(C/T)GCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BMX Gene

Variant ID Type Subtype PubMed ID
nsv510526 CNV Loss 20534489

Relevant External Links for BMX Gene

HapMap Linkage Disequilibrium report
BMX
Locus Specific Mutation Databases (LSDB)
BMX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMX Gene

Disorders for BMX Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BMX Gene in MalaCards »

(1) Diseases for BMX Gene including...

(1) University of Copenhagen DISEASES for BMX Gene

(6) Novoseek inferred disease relationships for BMX Gene

Disease -log(P) Hits PubMed IDs
x-linked agammaglobulinemia 81.9 1
prostate cancer 39.5 13
necrosis 7.71 3
tumors 0.533 7
breast cancer 0 1

Relevant External Links for BMX

Genetic Association Database (GAD)
BMX
Human Genome Epidemiology (HuGE) Navigator
BMX
genes like me logo Genes that share disorders with BMX: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for BMX Gene

Publications for BMX Gene

  1. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. (PMID: 7970727) Tamagnone L. … Alitalo K. (Oncogene 1994) 2 3 4 23
  2. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. (PMID: 10688651) Tsai Y.T. … Chen R.H. (Mol. Cell. Biol. 2000) 3 4 23
  3. Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. (PMID: 9520419) Qiu Y. … Kung H.-J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  4. Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. (PMID: 11331870) Chen R. … Qiu Y. (Nat. Cell Biol. 2001) 3 4 23
  5. Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx. (PMID: 11751885) Vargas L. … Mohamed A.J. (J. Biol. Chem. 2002) 3 4 23

Products for BMX Gene

  • Addgene plasmids for BMX

Sources for BMX Gene

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