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BMX Gene

protein-coding GIFtS: 63

GC0XP015392

BMX non-receptor tyrosine kinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.2 ^³
ETK ^¹, ², ³
NTK38 ^³
OTTHUMP00000022964 ^²
OTTHUMP00000022965 ^²
OTTHUMP00000022966 ^²
PSCTK2 ^²
PSCTK3 ^¹, ²

Descriptions
BMX non-receptor tyrosine kinase ^²
Bone marrow tyrosine kinase gene in chromosome X protein ^³
Epithelial and endothelial tyrosine kinase ^³

External Ids
HGNC: 1079¹
Entrez Gene: 660²
UniProtKB: P51813³
Ensembl: ENSG00000102010⁷

Search outside databases for aliases for BMX gene

Previous GC identifers: GC0XP015192 GC0XP014308 GC0XP014684 GC0XP014886 GC0XP014880 GC0XP015242

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BMX:

Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular

domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs

includes the genes TEC (MIM 600583), TXK (MIM 600058), ITK (MIM 186973), and BTK (MIM 300300). All

of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain

upstream of the TK domain.[supplied by OMIM]

UniProtKB/Swiss-Prot: BMX_HUMAN, P51813

Function: Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in

the growth and differentiation of hematopoietic cells. May be involved in signal transduction in

endocardial and arterial endothelial cells

Gene Wiki entry for BMX

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BMX gene

Entrez Gene cytogenetic band: Xp22.2 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.2

BMX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP015392: (about GC identifiers)

Start:	15,392,290 bp from pter
End:	15,484,573 bp from pter
Size:	92,284 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011757.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BMX_HUMAN, P51813 (See protein sequence)

Recommended Name: Cytoplasmic tyrosine-protein kinase BMX

Size: 675 amino acids; 78011 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subunit: Interacts with RUFY1 and RUFY2

Subcellular location: Cytoplasm (Probable)

PDB structure from and Proteopedia :

2EKX (3D)

2YS2 (3D)

Secondary accessions: A6NIH9 O60564 Q12871

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001712.1 NP_975010.1

ENSEMBL proteins:

ENSP00000308774 ENSP00000350224 ENSP00000340082

Human Recombinant Proteins

	Invitrogen human recombinant proteins for BMX
	Millipore Purified and/or Recombinant BMX Protein
	Sigma-Aldrich Proteins for BMX
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for BMX
	Recombinant Proteins from Abcam (BMX)
	Human Recombinant Proteins from Abnova (BMX)

OriGene Purified Recombinant Human Protein: BMX

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IDA	18029348

About this table

Antibodies for BMX:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for BMX
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for BMX (BMX/Etk, Etk)
	Antibodies from Abcam (BMX), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for BMX

Assays for BMX:

	Invitrogen Assays for BMX
	Millipore Kits and Assays for the Analysis of BMX
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P51813

ProtoNet protein and cluster: P51813

4 Blocks protein families:

IPB000980 SH2 domain signature

IPB001562 Tec/Btk domain signature

IPB001849 Pleckstrin-like

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: BMX_HUMAN, P51813

Domain: SH2 domain mediates interaction with RUFY1

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily

Similarity: Contains 1 Btk-type zinc finger

Similarity: Contains 1 PH domain

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH2 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BMX)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BMX)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_203281

Applied Biosystems Silencer® siRNAs for BMX

Sigma-Aldrich siRNA and siRNA Panels for BMX

Sigma-Aldrich shRNA Panels and shRNA for BMX

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BMX
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001721
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001721
untagged cDNA clones in CMV expression vector (see all 3): NM_001721

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_203281

UniProtKB/Swiss-Prot: BMX_HUMAN, P51813

Function: Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in

the growth and differentiation of hematopoietic cells. May be involved in signal transduction in

endocardial and arterial endothelial cells

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Induction: Activated by IL-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is

likely that activation occurs through binding of phosphoinositides to the PH domain

Enzyme Number (IUBMB): EC 2.7.10.2

Genatlas biochemistry entry for BMX:

bone marrow tyrosine kinase,X-linked,involved in growth and differentiation of hematopoietic

cells,SRC family,Tec subfamily

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Bmx):

normal

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	--
GO:0004871	signal transducer activity	TAS	9520419
GO:0005515	protein binding	IPI	16186805 17474147
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for BMX (Your Favorite Gene powered by Ingenuity)

Leukocyte Extravasation Signaling
T Cell Receptor Signaling

GeneDecks BMX for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BMX

5/14 Interacting proteins for BMX (P51813^{1, 2} ENSP00000350224³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIM1	P11309¹^,²	EBI-696657, EBI-696621 MINT-68562 MINT-68561 MINT-68560 MINT-68563 EBI-696657, EBI-696621 MINT-68562 MINT-68561 MINT-68560 MINT-68563
TP53	P04637¹^,²	EBI-696657, EBI-366083 MINT-68565 EBI-696657, EBI-366083 MINT-68565
CRK	P46108¹	EBI-696657, EBI-886
PIM1	P11309¹^,²	EBI-696657, EBI-696621 MINT-68562 MINT-68561 MINT-68560 MINT-68563 EBI-696657, EBI-696621 MINT-68562 MINT-68561 MINT-68560 MINT-68563
TP53	P04637¹^,²	EBI-696657, EBI-366083 MINT-68565 EBI-696657, EBI-366083 MINT-68565

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	TAS	7970727
GO:0007242	intracellular signaling cascade	IEA	--
GO:0007498	mesoderm development	TAS	9520419

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for BMX

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BMX
3 Novoseek chemical compound relationships for BMX gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	74.13	64	7970727 (4), 10688651 (3), 9323053 (3), 8790141 (2) (see all 40)
phosphatidylinositol	56.08	15	17823122 (5), 9520419 (2), 10608894 (1), 11382770 (1) (see all 6)
calcium	0.00	1	10224128 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BMX)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BMX)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_203281

Sigma-Aldrich siRNA and siRNA Panels for BMX

Sigma-Aldrich shRNA Panels and shRNA for BMX

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001721 NM_203281

REFSEQ mRNAs for BMX gene (2 alternative transcripts):

NM_001721.6 NM_203281.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001721 NM_203281

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001721
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001721
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001721

Additional cDNA sequence:

AF045459.1 AK291824.1 AK313568.1 BC016652.2 U08341.1 X83107.1

4 DOTS entries:

DT.97771039 DT.95363327 DT.100741067 DT.97839797

24/33 AceView cDNA sequences (see all 33 ):

Z40071 BQ229686 NM_001721 NM_203281 AI677766 BQ878627 AA297618 AI382692

BM804905 AF045459 X83107 BM544910 F02760 BU172565 F06481 CB998198

BE896015 F06972 BC016652 AI500626 BQ226991 AW512350 BQ350352 AA303367

highest scoring ESTs for BMX:

X83107 AA187327 AF045459 AI335555 AI382692 AI500626 AI677766 BC016652 BX102696 F02760

Unigene Cluster for BMX:

BMX non-receptor tyrosine kinase

Hs.495731 [show with all ESTs]

Unigene Representative Sequence: AF045459

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000348343 ENST00000357607 ENST00000342014

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BMX expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BMX

¹ / ² / ³

3 probe-sets matching BMX gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
962_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X83107	1.00	1.00	1.00	1
206464_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001721	0.60	1.00	0.82	1
206464_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTAAAGACT

SOURCE GeneReport for Unigene cluster: Hs.495731
Expression variation in blood from EXPOLDB for BMX
UniProtKB/Swiss-Prot: BMX_HUMAN, P51813
Tissue specificity: Preferentially expressed in epithelial and endothelial cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BMX gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BMX¹	--	BMX non-receptor tyrosine kinase	89.21(n) 91.72(a)	491750 XM_548870.2 XP_548870.2
cow (Bos taurus)	BMX¹	--	BMX non-receptor tyrosine kinase	91.97(n) 93.25(a)	531514 XM_610012.3 XP_610012.2
rat (Rattus norvegicus)	Bmx¹	--	BMX non-receptor tyrosine kinase	86.83(n) 89.49(a)	367786 XM_346302.3 XP_346303.3
mouse (Mus musculus)	Bmx^{1, 5}	X⁵	BMX non-receptor tyrosine kinase^{1, 5}	89.21(n)¹ 91.22(a)¹	12169¹ NM_009759.3¹ NP_033889.1¹ AF012104⁵ AK036707⁵ (see all 11)
chicken (Gallus gallus)	BMX¹	--	BMX non-receptor tyrosine kinase	70.66(n) 69.29(a)	428003 XM_425573.2 XP_425573.2

About this table Species with no ortholog for BMX

ENSEMBL Gene Tree for BMX

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BMX gene

TEC² ITK² TXK² BTK²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/223 NCBI SNPs in BMX are shown (see all 223 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 103)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6527616^1,2	A,C,F,H	15426895(+)	`AGCAGG/ATTGCC`	1	--	ng5¹		11	EU EA WA NA	874
	rs16997070^1,2	C,F,H	15434368(+)	`AAATCA/GATTCA`	2	--	int¹ ng5¹		11	NA EU EA WA	744
--	rs5935989^1,2	C,F,H	15428043(+)	`GCTAAT/GTCCAT`	1	--	ng5¹		4	EU EA WA	420
	rs16979929^1,2	C,F,H	15428753(+)	`TCAATC/GAGATC`	1	--	ng5¹		7	NA EU EA WA	536
	rs16979925^1,2	C,F,H	15428120(+)	`TTCACA/GTCATA`	1	--	ng5¹		11	NA EU EA WA	770
	rs10521648^1,2	C,F,H	15433503(+)	`ATTACG/AGACTC`	2	--	ng5¹ int¹		12	NS EU EA WA NA	649
	rs16979926^1,2	F,H	15428197(+)	`AAAGGA/GTGATT`	1	--	ng5¹		7	NA EU EA WA	502
	rs16979928^1,2	F,H	15428436(+)	`AATAAG/CCTCCT`	1	--	ng5¹		7	NA EU EA WA	536
	rs16997073^1,2	F,H	15434934(+)	`TTATTA/GTATTG`	2	--	ng5¹ int¹		7	NA EU EA WA	560
	rs233566^1,2	H	15433651(+)	`TGCATA/GTGAAT`	2	--	ng5¹ int¹		7	NA EA EU WA	670

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HapMap Linkage Disequilibrium images for BMX (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300101

6 Novoseek disease relationships for BMX gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
x-linked agammaglobulinemia	82.70	1	7970727 (1)
prostate cancer	41.78	30	16912182 (5), 15355990 (2), 9520419 (2), 14981536 (2) (see all 6)
necrosis	0.00	4	14532277 (2), 12370298 (1)
cancer	0.00	4	11382770 (2), 16276002 (1)
breast cancer	0.00	1	11382770 (1)
tumors	0.00	10	14532277 (2), 18196928 (2), 12370298 (1), 18413754 (1) (see all 5)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/70 PubMed articles for BMX gene (see all 70 ):

BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. (PubMed id 7970727)^{1, 2, 3, 4} Tamagnone L.... Alitalo K. (1994)
Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. (PubMed id 9520419)^{1, 3, 4} Qiu Y.... Kung H.-J. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases. (PubMed id 12573241)^{3, 4} Nore B.F....Smith C.I. (2003)
Interaction between tyrosine kinase Etk and a RUN-domain and FYVE- domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking. (PubMed id 11877430)^{3, 4} Yang J.... Qiu Y. (2002)
Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. (PubMed id 10688651)^{1, 3} Tsai Y.T....Chen R.H. (2000)
Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse. (PubMed id 16912182)^{1, 3} Dai B....Qiu Y. (2006)
Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis. (PubMed id 12370298)^{1, 3} Pan S....Min W. (2002)
Proteolytic activation of ETK/Bmx tyrosine kinase by caspases. (PubMed id 11278797)^{1, 3} Wu Y.M....Huang C.Y. (2001)
Activation of nonreceptor tyrosine kinase Bmx/Etk mediated by phosphoinositide 3-kinase, epidermal growth factor receptor, and ErbB3 in prostate cancer cells. (PubMed id 17823122)^{1, 3} Jiang X....Balk S.P. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 660	HGNC: 1079	AceView: BMX	Ensembl:ENSG00000102010	euGenes: HUgn660
ECgene: BMX	H-InvDB: BMX

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BMX	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for BMX
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BMX:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BMX-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BMX		Antibodies for BMX
	Explore super-pooled esiRNAs		Proteins for BMX
	Lentivirus-delivered shRNAs for BMX		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BMX)
	Search for Antibodies
	Chimera RNAi (BMX)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for BMX (BMX/Etk, Etk)

	Recombinant Proteins (BMX)
	Antibodies (BMX)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for BMX

	Drugs/Proteins for BMX
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BMX

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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BMX Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for BMX

Summaries
for BMX

Genomic Location
for BMX

Proteins
for BMX

Protein Domains/
Families
for BMX

Gene Function
for BMX

Pathways & Interactions
for BMX

Drugs & Compounds
for BMX

Transcripts
for BMX

Expression
for BMX

Orthologs
for BMX

Paralogs
for BMX

SNPs/Variants
for BMX

Disorders & Mutations
for BMX

Medical News
for BMX

Publications
for BMX

Search for BMX

Genome Databases showing BMX

Other Databases showing BMX

Specialized Databases showing BMX

Licensable Technologies
for BMX

Services
for BMX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BMX Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor BMX

Summariesfor BMX

Genomic Locationfor BMX

Proteinsfor BMX

Protein Domains/Familiesfor BMX

Gene Functionfor BMX

Pathways & Interactionsfor BMX

Drugs & Compoundsfor BMX

Transcriptsfor BMX

Expression for BMX

Orthologsfor BMX

Paralogsfor BMX

SNPs/Variantsfor BMX

Disorders & Mutationsfor BMX

Medical Newsfor BMX

Publicationsfor BMX

Search for BMX

Genome Databases showing BMX

Other Databases showing BMX

Specialized Databases showing BMX

Licensable Technologiesfor BMX

Servicesfor BMX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BMX

Summaries
for BMX

Genomic Location
for BMX

Proteins
for BMX

Protein Domains/
Families
for BMX

Gene Function
for BMX

Pathways & Interactions
for BMX

Drugs & Compounds
for BMX

Transcripts
for BMX

Expression
for BMX

Orthologs
for BMX

Paralogs
for BMX

SNPs/Variants
for BMX

Disorders & Mutations
for BMX

Medical News
for BMX

Publications
for BMX

Licensable Technologies
for BMX

Services
for BMX