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Aliases for BMX Gene

Aliases for BMX Gene

  • BMX Non-Receptor Tyrosine Kinase 2 3 5
  • Bone Marrow Tyrosine Kinase Gene In Chromosome X Protein 3 4
  • Epithelial And Endothelial Tyrosine Kinase 3 4
  • BTK-Like On X Chromosome 2 3
  • EC 2.7.10.2 4 61
  • ETK 3 4
  • Cytoplasmic Tyrosine-Protein Kinase BMX 3
  • Etk/Bmx Cytosolic Tyrosine Kinase 3
  • NTK38 Tyrosine Kinase 3
  • EC 2.7.10 61
  • PSCTK2 3
  • PSCTK3 3
  • NTK38 4

External Ids for BMX Gene

Previous GeneCards Identifiers for BMX Gene

  • GC0XP015192
  • GC0XP014308
  • GC0XP014684
  • GC0XP014886
  • GC0XP014880
  • GC0XP015242
  • GC0XP013280

Summaries for BMX Gene

Entrez Gene Summary for BMX Gene

  • This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

GeneCards Summary for BMX Gene

BMX (BMX Non-Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with BMX include Ariboflavinosis and Prostate Cancer. Among its related pathways are Immune response IL-23 signaling pathway and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is BTK.

UniProtKB/Swiss-Prot for BMX Gene

  • Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.

Gene Wiki entry for BMX Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMX Gene

Genomics for BMX Gene

Regulatory Elements for BMX Gene

Enhancers for BMX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG015850 0.5 FANTOM5 42.4 +386.1 386105 0.4 ZNF316 EMSY BMX AP1S2 ZRSR2
GH0XG015343 0.8 ENCODE 11.2 -121.0 -121013 0.2 GTF2F1 PKNOX1 JUN ZFP64 MAX SIN3A BRCA1 RFX5 CTBP1 GATA3 BMX PIGA VEGFD
GH0XG015564 0.7 ENCODE 11.5 +101.2 101183 1.0 GTF2F1 CTCF ZNF654 STAT1 RFX1 TRIM22 REST RAD21 GATA2 SMC3 PIR BMX ACE2
GH0XG015417 0.6 ENCODE 12.8 -45.8 -45770 1.3 HDAC1 JUND PBX2 IKZF1 BHLHE40 JUNB HNF4A MAFK PIR BMX VEGFD
GH0XG015356 0.6 ENCODE 12.2 -107.6 -107603 0.1 HLF CEBPB RAD21 YY1 FOXA1 JUND FOXP2 HNF4A PIGA ASB11 BMX PIR ACE2 GS1-594A7.3 VEGFD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BMX on UCSC Golden Path with GeneCards custom track

Genomic Location for BMX Gene

Chromosome:
X
Start:
15,464,246 bp from pter
End:
15,556,529 bp from pter
Size:
92,284 bases
Orientation:
Plus strand

Genomic View for BMX Gene

Genes around BMX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BMX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BMX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMX Gene

Proteins for BMX Gene

  • Protein details for BMX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51813-BMX_HUMAN
    Recommended name:
    Cytoplasmic tyrosine-protein kinase BMX
    Protein Accession:
    P51813
    Secondary Accessions:
    • A6NIH9
    • O60564
    • Q12871

    Protein attributes for BMX Gene

    Size:
    675 amino acids
    Molecular mass:
    78011 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with BCAR1, CAV1, MYD88, PTK2/FAK1, RUFY1, RUFY2, STAT3, TIRAP and TNFRSF1B.
    SequenceCaution:
    • Sequence=AAC08966.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BMX Gene

neXtProt entry for BMX Gene

Selected DME Specific Peptides for BMX Gene

P51813:
  • RDLAARN
  • VKFYGVC
  • PIYIVTE
  • LSYYEYD
  • YHQHNSAG
  • NGCLLNYL
  • RLYRPHLA

Post-translational modifications for BMX Gene

  • Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis leads to activation and is required for STAT3 phosphorylation by BMX.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BMX Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BMX (Etk)
  • Abcam antibodies for BMX

Domains & Families for BMX Gene

Suggested Antigen Peptide Sequences for BMX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51813

UniProtKB/Swiss-Prot:

BMX_HUMAN :
  • SH2 domain mediates interaction with RUFY1.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Domain:
  • SH2 domain mediates interaction with RUFY1.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
genes like me logo Genes that share domains with BMX: view

Function for BMX Gene

Molecular function for BMX Gene

GENATLAS Biochemistry:
bone marrow tyrosine kinase,X-linked,involved in growth and differentiation of hematopoietic cells,SRC family,Tec subfamily
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
TEK and vascular endothelial growth factor receptor 1 (FLT1) stimulate BMX tyrosine kinase activity (By similarity). Activated by integrins through the mediation of PTK2/FAK1. Activated by TNF through the mediation of TNFRSF1B.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
UniProtKB/Swiss-Prot Induction:
Activated by IL6/interleukin-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain.

Enzyme Numbers (IUBMB) for BMX Gene

Gene Ontology (GO) - Molecular Function for BMX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS 7970727
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS --
GO:0004871 signal transducer activity TAS 9520419
GO:0005102 NOT receptor binding IBA --
genes like me logo Genes that share ontologies with BMX: view
genes like me logo Genes that share phenotypes with BMX: view

Animal Models for BMX Gene

MGI Knock Outs for BMX:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BMX
  • Applied Biological Materials Clones for BMX

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for BMX Gene

Localization for BMX Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMX Gene

Cytoplasm. Note=Localizes to the edges of spreading cells when complexed with BCAR1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BMX gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for BMX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with BMX: view

Pathways & Interactions for BMX Gene

genes like me logo Genes that share pathways with BMX: view

SIGNOR curated interactions for BMX Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for BMX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001865 NK T cell differentiation IBA --
GO:0006468 protein phosphorylation TAS 7970727
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006915 apoptotic process IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with BMX: view

Drugs & Compounds for BMX Gene

(6) Drugs for BMX Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
BMX-IN-1 Pharma BMX (also termed ETK) kinase inhibitor 0

(3) Additional Compounds for BMX Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for BMX Gene

Compound Action Cas Number
BMX-IN-1 BMX (also termed ETK) kinase inhibitor 1431525-23-3
genes like me logo Genes that share compounds with BMX: view

Drug Products

Transcripts for BMX Gene

Unigene Clusters for BMX Gene

BMX non-receptor tyrosine kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BMX
  • Applied Biological Materials Clones for BMX

Alternative Splicing Database (ASD) splice patterns (SP) for BMX Gene

No ASD Table

Relevant External Links for BMX Gene

GeneLoc Exon Structure for
BMX
ECgene alternative splicing isoforms for
BMX

Expression for BMX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BMX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BMX Gene

This gene is overexpressed in Whole Blood (x16.8) and Heart - Atrial Appendage (x4.6).

Protein differential expression in normal tissues from HIPED for BMX Gene

This gene is overexpressed in Cerebrospinal fluid (41.2) and Pancreatic juice (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BMX Gene



Protein tissue co-expression partners for BMX Gene

NURSA nuclear receptor signaling pathways regulating expression of BMX Gene:

BMX

SOURCE GeneReport for Unigene cluster for BMX Gene:

Hs.495731

mRNA Expression by UniProt/SwissProt for BMX Gene:

P51813-BMX_HUMAN
Tissue specificity: Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.

Evidence on tissue expression from TISSUES for BMX Gene

  • Bone marrow(4.4)
  • Blood(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with BMX: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BMX Gene

Orthologs for BMX Gene

This gene was present in the common ancestor of animals.

Orthologs for BMX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BMX 35 34
  • 93.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BMX 35 34
  • 92.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia BMX 35 34
  • 89.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Bmx 34 16 35
  • 88.75 (n)
rat
(Rattus norvegicus)
Mammalia Bmx 34
  • 87.88 (n)
oppossum
(Monodelphis domestica)
Mammalia BMX 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BMX 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves BMX 35 34
  • 69.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BMX 35
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Btk29A 36 35
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea T14E8.1a 36
  • 34 (a)
T14E8.1b 36
  • 34 (a)
F26E4.5 36
  • 33 (a)
spe-8 36
  • 32 (a)
C25A8.5 36
  • 31 (a)
F22B3.8 36
  • 31 (a)
R05H5.4 36
  • 31 (a)
T25B9.4 36
  • 31 (a)
F23C8.7 36
  • 30 (a)
F59A3.8 36
  • 28 (a)
kin-24 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
ManyToMany
Species where no ortholog for BMX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for BMX Gene

ENSEMBL:
Gene Tree for BMX (if available)
TreeFam:
Gene Tree for BMX (if available)

Paralogs for BMX Gene

Paralogs for BMX Gene

(23) SIMAP similar genes for BMX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BMX: view

Variants for BMX Gene

Sequence variations from dbSNP and Humsavar for BMX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_041675 A lung large cell carcinoma sample
rs1000009210 -- 15,527,253(+) ATATA(G/T)ATATA intron-variant
rs1000064566 -- 15,501,225(+) CACCA(A/G)TTCTA intron-variant
rs1000216366 -- 15,544,003(+) TAGTC(C/G)CTGCT intron-variant
rs1000257980 -- 15,514,282(+) TAATT(C/T)TCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BMX Gene

Variant ID Type Subtype PubMed ID
nsv510526 OTHER sequence alteration 20534489

Variation tolerance for BMX Gene

Residual Variation Intolerance Score: 39.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BMX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BMX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMX Gene

Disorders for BMX Gene

MalaCards: The human disease database

(2) MalaCards diseases for BMX Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ariboflavinosis
  • riboflavin deficiency
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search BMX in MalaCards View complete list of genes associated with diseases

Relevant External Links for BMX

Genetic Association Database (GAD)
BMX
Human Genome Epidemiology (HuGE) Navigator
BMX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BMX
genes like me logo Genes that share disorders with BMX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BMX Gene

Publications for BMX Gene

  1. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. (PMID: 7970727) Tamagnone L. … Alitalo K. (Oncogene 1994) 2 3 4 22 64
  2. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. (PMID: 18292575) Semaan N. … Sibilia J. (J. Immunol. 2008) 3 4 22 64
  3. Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis. (PMID: 12370298) Pan S. … Min W. (Mol. Cell. Biol. 2002) 3 4 22 64
  4. Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx. (PMID: 11751885) Vargas L. … Mohamed A.J. (J. Biol. Chem. 2002) 3 4 22 64
  5. Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. (PMID: 11331870) Chen R. … Qiu Y. (Nat. Cell Biol. 2001) 3 4 22 64

Products for BMX Gene

  • Addgene plasmids for BMX

Sources for BMX Gene

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