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Aliases for BMT2 Gene

Aliases for BMT2 Gene

  • Base Methyltransferase Of 25S RRNA 2 Homolog 2 3
  • C7orf60 3 4 5
  • Chromosome 7 Open Reading Frame 60 2 5
  • Hypothetical Protein FLJ31818 2
  • UPF0532 Protein C7orf60 3
  • EC 2.1.1.- 4

External Ids for BMT2 Gene

Previous HGNC Symbols for BMT2 Gene

  • C7orf60

Summaries for BMT2 Gene

GeneCards Summary for BMT2 Gene

BMT2 (Base Methyltransferase Of 25S RRNA 2 Homolog) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BMT2 Gene

  • Probable S-adenosyl-L-methionine-dependent methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMT2 Gene

Genomics for BMT2 Gene

Regulatory Elements for BMT2 Gene

Enhancers for BMT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BMT2 on UCSC Golden Path with GeneCards custom track

Promoters for BMT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BMT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BMT2 Gene

Chromosome:
7
Start:
112,819,147 bp from pter
End:
112,939,916 bp from pter
Size:
120,770 bases
Orientation:
Minus strand

Genomic View for BMT2 Gene

Genes around BMT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BMT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BMT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMT2 Gene

Proteins for BMT2 Gene

  • Protein details for BMT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1RMZ1-BMT2_HUMAN
    Recommended name:
    Probable methyltransferase BTM2 homolog
    Protein Accession:
    Q1RMZ1
    Secondary Accessions:
    • Q8N3D0
    • Q96MV7

    Protein attributes for BMT2 Gene

    Size:
    405 amino acids
    Molecular mass:
    46324 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71169.1; Type=Frameshift; Positions=259; Evidence={ECO:0000305};

neXtProt entry for BMT2 Gene

Proteomics data for BMT2 Gene at MOPED

Post-translational modifications for BMT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BMT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BMT2 Gene

Domains & Families for BMT2 Gene

Protein Domains for BMT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BMT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1RMZ1

UniProtKB/Swiss-Prot:

BMT2_HUMAN :
  • Belongs to the BMT2 family.
Family:
  • Belongs to the BMT2 family.
genes like me logo Genes that share domains with BMT2: view

No data available for Gene Families for BMT2 Gene

Function for BMT2 Gene

Molecular function for BMT2 Gene

UniProtKB/Swiss-Prot Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase.

Enzyme Numbers (IUBMB) for BMT2 Gene

genes like me logo Genes that share phenotypes with BMT2: view

Animal Model Products

miRNA for BMT2 Gene

miRTarBase miRNAs that target BMT2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BMT2 Gene

Localization for BMT2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for BMT2 Gene

Pathways & Interactions for BMT2 Gene

SuperPathways for BMT2 Gene

No Data Available

Interacting Proteins for BMT2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297145%0d%0a9606.ENSP00000261758%0d%0a
Selected Interacting proteins: ENSP00000297145 for BMT2 Gene via STRING

Symbol External ID(s) Details
MESDC2

Gene Ontology (GO) - Biological Process for BMT2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BMT2 Gene

Drugs & Compounds for BMT2 Gene

No Compound Related Data Available

Transcripts for BMT2 Gene

mRNA/cDNA for BMT2 Gene

Unigene Clusters for BMT2 Gene

Chromosome 7 open reading frame 60:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BMT2 Gene

No ASD Table

Relevant External Links for BMT2 Gene

GeneLoc Exon Structure for
BMT2
ECgene alternative splicing isoforms for
BMT2

Expression for BMT2 Gene

SOURCE GeneReport for Unigene cluster for BMT2 Gene Hs.489734

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BMT2 Gene

Orthologs for BMT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BMT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C4H7orf60 35
  • 95.14 (n)
  • 96.3 (a)
C7orf60 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C14H7orf60 35
  • 94.24 (n)
  • 96.79 (a)
C7orf60 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B630005N14Rik 35
  • 89.5 (n)
  • 94.54 (a)
B630005N14Rik 16
B630005N14Rik 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC500034 35
  • 90.16 (n)
  • 96.28 (a)
oppossum
(Monodelphis domestica)
Mammalia C7orf60 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C7orf60 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C7orf60 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H7ORF60 35
  • 80.89 (n)
  • 88.09 (a)
C1H7ORF60 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C7orf60 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c7orf60 35
  • 72.92 (n)
  • 76.14 (a)
Str.2026 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7372 35
zebrafish
(Danio rerio)
Actinopterygii zgc:153606 35
  • 68.36 (n)
  • 75.67 (a)
C25H7orf60 36
  • 71 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.858 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008978 35
  • 47.33 (n)
  • 40.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3570 35
  • 43.37 (n)
  • 36.92 (a)
CG3570 36
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for BMT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BMT2 Gene

ENSEMBL:
Gene Tree for BMT2 (if available)
TreeFam:
Gene Tree for BMT2 (if available)

Paralogs for BMT2 Gene

No data available for Paralogs for BMT2 Gene

Variants for BMT2 Gene

Sequence variations from dbSNP and Humsavar for BMT2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs768517 -- 112,908,376(+) TGGGT(A/C)TAGAG intron-variant
rs821782 -- 112,847,765(-) gtttc(A/G)ctctt intron-variant
rs821783 -- 112,829,723(+) gttac(A/G)tggga intron-variant
rs821784 -- 112,834,592(+) aaatt(C/G)tcaca intron-variant
rs821785 -- 112,824,786(-) cttac(A/G)tacgt intron-variant

Variation tolerance for BMT2 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for BMT2 Gene

Disorders for BMT2 Gene

Relevant External Links for BMT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BMT2

No disorders were found for BMT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BMT2 Gene

Publications for BMT2 Gene

  1. Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae. (PMID: 23558746) Sharma S. … Entian K.D. (Nucleic Acids Res. 2013) 2 3 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney R.J. … Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for BMT2 Gene

Sources for BMT2 Gene

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