BMS1 Gene
protein-coding GIFtS: 51
GCID: GC10P043277
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BMS1 homolog, ribosome assembly protein (yeast)(Previous names: BMS1-like, ribosome assembly protein (yeast) )
(Previous symbol: BMS1L)
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Aliases
for BMS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BMS1 Homolog, Ribosome Assembly Protein (Yeast)1 2 | | BMS1-Like, Ribosome Assembly Protein (Yeast)1 | | BMS1L1 2 3 | | BMS1-Like, Ribosome Assembly Protein2 | | KIAA01871 3 | | Ribosome Biogenesis Protein BMS1 Homolog2 | | Ribosome Assembly Protein BMS1 Homolog2 3 | | |
Export aliases for BMS1 gene to outside databasesPrevious GC identifers: GC10P042599 GC10P039804 |
Summaries
for BMS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BMS1:
This gene likely encodes a ribosome assembly protein. A similar protein in yeast functions in 35S-rRNA processing,which includes a series of cleavage steps critical for formation of 40S ribosomes. Related pseudogenes exist onchromosomes 2, 9, 10, 15, 16, and 22.(provided by RefSeq, Mar 2009)
UniProtKB/Swiss-Prot: BMS1_HUMAN, Q14692Function: May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)
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Genomic Views
for BMS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_033985.7
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BMS1 gene promoter:
USF1 STAT1 USF2 STAT1beta USF-1:USF-2 CUTL1 HNF-1A STAT1alpha HNF-1 USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BMS1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMS1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.21 Ensembl cytogenetic band: 10q11.21 HGNC cytogenetic band: 10q11.21BMS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P043277: view genomic region
(about GC identifiers)
Start:
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43,277,954 bp from pter |
End:
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43,330,385 bp from pter |
Size:
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52,432 bases |
Orientation:
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plus strand |
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Proteins
for BMS1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BMS1_HUMAN, Q14692 (See
protein sequence)Recommended Name: Ribosome biogenesis protein BMS1 homolog Size: 1282 amino acids; 145807 Da
Subcellular location: Nucleus, nucleolus (By similarity)
Sequence caution: Sequence=BAA11504.2; Type=Erroneous initiation;
Secondary accessions: Q5QPT5 Q86XJ9Explore the universe of human proteins at neXtProt for BMS1: NX_Q14692
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14692
BMS1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055568.3
ENSEMBL proteins: ENSP00000363642
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
BMS1 for ontologies About GeneDecksing
BMS1 Antibody Products:
Assay Products for BMS1: |
Protein
Domains /
Families
for BMS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BMS1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14692ProtoNet protein and cluster: Q14692 1 Blocks protein family: IPB012948 AARP2CN
UniProtKB/Swiss-Prot: BMS1_HUMAN, Q14692Similarity: Belongs to the BMS1/TSR1 family. BMS1 subfamily |
Function
for BMS1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BMS1_HUMAN, Q14692Function: May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMS1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): BMS1 (NM_016836) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BMS1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMS1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMS1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
BMS1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for BMS1:
|
Pathways & Interactions
for BMS1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ribosome biogenesis in eukaryotes | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for BMS1):
BMS1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BMS1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/197 Interacting proteins for BMS1 (Q146923 ENSP000003636424) via UniProtKB, MINT, STRING, and/or I2D (see all 197)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0042255 | ribosome assembly |
ISS | -- |
BMS1 for ontologies About GeneDecksing
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Drugs & Compounds
for BMS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BMS1
Search CenterWatch for drugs/clinical trials and news about BMS1
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Transcripts
for BMS1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BMS1 gene: NM_014753.3 Unigene Cluster for BMS1: BMS1 homolog, ribosome assembly protein (yeast) Hs.10848 [show with all ESTs]Unigene Representative Sequence: NM_0147531 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000374518(uc001jaj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMS1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMS1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): BMS1 (NM_016836) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BMS1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMS1 |
Additional cDNA sequence: AK308420.1 BC043345.1 BC150252.1 D80009.1 24 DOTS entries: DT.75116117 DT.91807063 DT.434102 DT.95325285 DT.86859760 DT.120678042 DT.100732238 DT.86857132 DT.91879566 DT.100042632 DT.100044818 DT.100044819 DT.120678004 DT.121248418 DT.121248435 DT.121248441 DT.92066201 DT.95169030 DT.95328755 DT.101973107 DT.92019415 DT.95169037 DT.97859885 DT.99955615 24/237 AceView cDNA sequences (see all 237): AA293345 BU162655 CB119695 BU177526 BP357259 CF130988 CB157112 AA402812 BM722802 AA047147 BG231718 AI753409 BQ052188 BQ882635 BE336651 AA300924 AI049943 AI609068 AA405999 AA411513 BU501671 BC043345 BU628286 NM_014753
GeneLoc Exon Structure
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Expression
for BMS1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BMS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTGGGGCT
About this image
See BMS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BMS1
SOURCE GeneReport for Unigene cluster: Hs.10848
SABiosciences Custom PCR Arrays for BMS1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BMS1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BMS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMS1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMS1 |
Orthologs
for BMS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for BMS1 gene from 10/36 species (see all 36) About this table
ENSEMBL Gene Tree for BMS1 (if available)
TreeFam Gene Tree for BMS1 (if available) |
Paralogs
for BMS1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BMS1 gene
BMS1 for paralogs About GeneDecksing
5/21 Pseudogenes.org Pseudogenes for BMS1 (see all 21)
PGOHUM00000258476 PGOHUM00000238461 PGOHUM00000258482 PGOHUM00000258484 PGOHUM00000258488
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Genomic Variants
for BMS1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BMS1 (43277954 - 43330385 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for BMS1
8 CNVs: 70974 9147 3797 6863 31724 70975 2862 30483 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BMS1 |
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Disorders
/ Diseases
for BMS1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BMS1 for disorders About GeneDecksing
OMIM gene information: 611448
OMIM disorders: --
6  diseases for BMS1: About MalaCardssupranuclear palsy progressive supranuclear palsy fanconi's anemia tauopathy
anemia malaria
Human Genome Epidemiology (HuGE) Navigator: BMS1 (2 documents)
Export disorders for BMS1 gene to outside databases
|
Publications
for BMS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BMS1 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with BMS1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human paralogs of KIAA0187 were created through independent pericentromeric-directed and chromosome-specific duplication mechanisms. (PubMed id 11779832)1, 3 Crosier M....Jackson M.S. (2002)
- Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2 Nagase T.... Nomura N. (1996)
- Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (PubMed id 21685912)1 HAPglinger G.U....Schellenberg G.D. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
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External Searches for BMS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing BMS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BMS1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing BMS1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BMS1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for BMS1 gene:
Search GeneIP for patents involving BMS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BMS1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BMS1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMS1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BMS1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for BMS1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMS1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMS1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BMS1 | | OriGene Custom Protein Services for BMS1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BMS1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BMS1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMS1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMS1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMS1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMS1 |
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| | | | Search Tocris compounds for BMS1 |
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 | | | BMS1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMS1 |
|  |  |  | | | | Search ThermoFisher Antibodies for BMS1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMS1 |
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