V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

BMPR1B Gene

protein-coding GIFtS: 65

GC04P095991

bone morphogenetic protein receptor, type IB
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ALK-6 ^²
ALK6 ^¹, ², ⁵
CDw293 ^¹, ²
EC 2.7.11.30 ^³
OTTHUMP00000161622 ^²

Descriptions
CDw293 antigen ^³
activin receptor-like kinase 6 ^²
bone morphogenetic protein receptor, type IB ^²
serine/threonine receptor kinase ^²

External Ids
HGNC: 1077¹
Entrez Gene: 658²
UniProtKB: O00238³
Ensembl: ENSG00000138696⁷

Search outside databases for aliases for BMPR1B gene

Previous GC identifers: GC04P096144 GC04P096137 GC04P096036

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BMPR1B:

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane

serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta

superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins

transduce their signals through the formation of heteromeric complexes of 2 different types of

serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of

about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they

require their respective type I receptors for signaling, whereas type I receptors require their

respective type II receptors for ligand binding. Mutations in this gene have been associated with

primary pulmonary hypertension. [provided by RefSeq]

UniProtKB/Swiss-Prot: BMR1B_HUMAN, O00238

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I

transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I

receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Receptor for BMPS/OP-1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BMPR1B gene

Entrez Gene cytogenetic band: 4q22-q24 Ensembl cytogenetic band: 4q22.3 HGNC cytogenetic band: 4q23-q24

BMPR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P095991: (about GC identifiers)

Start:	95,898,151 bp from pter
End:	96,295,190 bp from pter
Size:	397,040 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BMR1B_HUMAN, O00238 (See protein sequence)

Recommended Name: Bone morphogenetic protein receptor type-1B precursor

Size: 502 amino acids; 56930 Da

Cofactor: Magnesium or manganese (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: P78366

REFSEQ proteins: NP_001194.1

ENSEMBL proteins:

ENSP00000378389 ENSP00000264568

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for BMPR1B
	R&D Systems Recombinant & Natural Proteins for BMPR1B (BMPR-IB/ALK-6)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BMPR1B)
	Human Recombinant Proteins from Abnova (BMPR1B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	EXP	17356069
GO:0005887	integral to plasma membrane	IC	14523231
GO:0043235	receptor complex	TAS	14523231

About this table

Antibodies for BMPR1B:

	Invitrogen Antibodies for BMPR1B
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for BMPR1B
	R&D Systems Antibodies for BMPR1B (BMPR-IB/ALK-6)
	Antibodies from Abcam (BMPR1B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BMPR1B)
	Novus Biologicals Antibodies for BMPR1B

Assays for BMPR1B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O00238

ProtoNet protein and cluster: O00238

1 Blocks protein family: IPB000472 Domain in TGF-beta receptor/activin receptor

UniProtKB/Swiss-Prot: BMR1B_HUMAN, O00238

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB

receptor subfamily

Similarity: Contains 1 GS domain

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BMPR1B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BMPR1B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001203

Applied Biosystems Silencer® siRNAs for BMPR1B

Sigma-Aldrich siRNA and siRNA Panels for BMPR1B

Sigma-Aldrich shRNA Panels and shRNA for BMPR1B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BMPR1B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001203
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001203
untagged cDNA clone in CMV expression vector: NM_001203

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001203

UniProtKB/Swiss-Prot: BMR1B_HUMAN, O00238

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I

transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I

receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Receptor for BMPS/OP-1

Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate

Enzyme Number (IUBMB): EC 2.7.11.30

Genatlas biochemistry entry for BMPR1B:

bone morphogenetic protein receptor,type 1B,predominantly expressed in prostate,TGFBR superfamily

11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bmpr1b):

craniofacial	embryogenesis	endocrine/exocrine gland	growth/size	lethality-prenatal/perinatal
limbs/digits/tail	nervous system	pigmentation	reproductive system	skeleton
vision/eye

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0005025	transforming growth factor beta receptor activity, type I	IEA	--
GO:0005524	ATP binding	IDA	12065756

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for BMPR1B (Your Favorite Gene powered by Ingenuity) (see all 8 )

Factors Promoting Cardiogenesis in Vertebrates
NF-&kappa
Cardiomyocyte Differentiation via BMP Receptors
TGF-&beta
Molecular Mechanisms of Cancer

GeneDecks BMPR1B for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BMPR1B

5/69 Interacting proteins for BMPR1B (O00238² ENSP00000264568³) via UniProtKB, MINT, and/or STRING (see all 69 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BMP2	ENSP00000368104³	STRING (score=.999)
BMP4	ENSP00000245451³	STRING (score=.999)
BMP6	ENSP00000283147³	STRING (score=.998)
BMP7	ENSP00000360340³	STRING (score=.997)
NOG	ENSP00000328181³	STRING (score=.996)

About this table

5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IMP	14523231
GO:0001502	cartilage condensation	NAS	14523231
GO:0001550	ovarian cumulus expansion	ISS	--
GO:0006468	protein amino acid phosphorylation	IDA	12065756
GO:0006954	inflammatory response	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BMPR1B
2 Novoseek chemical compound relationships for BMPR1B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	47.46	1	15621726 (1)
tyrosine	10.44	3	11467453 (1), 11106404 (1), 9722602 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BMPR1B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BMPR1B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001203

Sigma-Aldrich siRNA and siRNA Panels for BMPR1B

Sigma-Aldrich shRNA Panels and shRNA for BMPR1B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001203

REFSEQ mRNAs for BMPR1B gene:

NM_001203.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001203

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001203
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001203
                                 untagged cDNA clone in CMV expression vector: NM_001203

Additional cDNA sequence:

AK293008.1 AK299930.1 AK313642.1 BC047773.1 BC069796.1 BC069803.1 D89675.1 U89326.1

6 DOTS entries:

DT.105795 DT.100744182 DT.105783 DT.97774191 DT.121251548 DT.95286563

24/46 AceView cDNA sequences (see all 46 ):

AA334202 BE219575 BF108430 BX493471 AI732586 BC047773 AI984273 AA332882

D89675 AA250737 BC069796 BX953864 AA410943 BI035500 AI733881 BM981392

BF434716 R88395 CA389769 BM142314 BC069803 CD250597 CB048547 BX953863

highest scoring ESTs for BMPR1B:

U89326 BC047773 BC069796 BC069803 BF115446 BF434716 BF964573 BM142314 D89675 AA655034

Unigene Cluster for BMPR1B:

Bone morphogenetic protein receptor, type IB

Hs.598475 [show with all ESTs]

Unigene Representative Sequence: NM_001203

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000394931 ENST00000264568

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BMPR1B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BMPR1B

¹ / ² / ³

10 probe-sets matching BMPR1B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35021_at²^{, 3}	U95-A	1	1.00	1.00	0.05	0.30	U89326	1.00	1.00	1.00	1
48755_s_at²	U95-B	1	1.00	1.00	0.92	1.16	--	--	--	--	--
53771_at²	U95-C	1	1.00	1.00	0.98	0.97	--	--	--	--	--
84011_at²	U95-E	1	1.00	1.00	0.94	0.88	--	--	--	--	--
242579_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
210523_at²^{, 3}	U133-A	3	1.00	0.94	--	--	D89675	0.80	1.00	0.91	1
229975_at²	U133-B	1	0.91	1.00	--	--	--	--	--	--	--
242579_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210523_at²	U133Plus2	3	1.00	0.94	--	--	--	--	--	--	--
229975_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks BMPR1B for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTCAGTAGTT

SOURCE GeneReport for Unigene cluster: Hs.598475
Expression variation in blood from EXPOLDB for BMPR1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BMPR1B gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BMPR1B¹	--	bone morphogenetic protein receptor, type IB	93.89(n) 98.41(a)	478484 XM_845507.1 XP_850600.1
chimpanzee (Pan troglodytes)	BMPR1B¹	--	bone morphogenetic protein receptor, type IB	99.47(n) 99.2(a)	461683 XM_517599.2 XP_517599.2
cow (Bos taurus)	BMPR1B¹	--	bone morphogenetic protein receptor, type IB	92.63(n) 98.61(a)	407128 XM_612088.3 XP_612088.3
mouse (Mus musculus)	Bmpr1b^{1, 5}	3⁵	bone morphogenetic protein receptor, type 1B^{1, 5}	89.24(n)¹ 98.21(a)¹	12167¹ NM_007560.3¹ NP_031586.1¹ AI385617⁵ AI464533⁵ (see all 14)
chicken (Gallus gallus)	BMPR1B¹	--	bone morphogenetic protein receptor, type IB	80.94(n) 91.43(a)	396030 NM_205132.1 NP_990463.1

About this table Species with no ortholog for BMPR1B

ENSEMBL Gene Tree for BMPR1B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BMPR1B gene

BMPR1A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2531 NCBI SNPs in BMPR1B are shown (see all 2531 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 842)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1434536^1,2	A,C,F,H,O	96294988(-)	`CCTGAG/AAGGTG`	1	--	ut3¹ ese³		12		EA NA MN EU WA	904
	rs1836261^1,2	A,C,F,H,O	96295043(-)	`AGACAC/TGGATC`	1	--	ut3¹ ese³		15		NS NA EU EA WA	921
	rs11097457^1,2	A,C,F,H	96295836(+)	`ATAGGG/AAATGA`	1	--	ut3¹		8		EU EA WA	836
	rs1863654^1,2	A,C,F,H	96297197(-)	`TCCACG/ATTCAA`	1	--	ut3¹		3		EA WA	268
	rs2289044^1,2	C,F,H	96296406(-)	`ATGTAT/CATGAA`	1	--	ut3¹		9		EA EU WA NA	2114
	rs12505161^1,2	C,H	96298150(+)	`TGACTG/AAATTT`	1	--	ut3¹		4		EU EA WA	394
	rs6813320^1,2	F,H	96294896(+)	`CTCTTC/TTGTTT`	1	--	ut3¹ ese³		4		EU EA WA	420
	rs17023107^1,2	F,H	96295488(+)	`TCCTGC/TAGGTG`	1	--	ut3¹		7		NA EU EA WA	558
	rs1434535^1,2	A,C	96297623(-)	`TCTCAC/TTTATT`	1	--	ut3¹		0	--	--	--	--
	rs2162449^1,2	A,H	96298102(-)	`GAAATG/CTGTCA`	1	--	ut3¹		3		EA WA	274

About this table

HapMap Linkage Disequilibrium images for BMPR1B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603248 disorders: 112600 609441

UniProtKB/Swiss-Prot: BMR1B_HUMAN, O00238

Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies

(AMDGA) [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders

characterized by short stature, very short limbs, and hand/foot malformations. The severity of

limb abnormalities increases from proximal to distal with profoundly affected hands and feet

showing brachydactyly and/or rudimentary fingers (knob-like fingers)

Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600].

Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the

digits due to abnormal development of the phalanges and/or the metacarpals. They have been

classified on an anatomic and genetic basis into five groups, A to E, including three subgroups

(A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large

Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these

mutations function as dominant negatives in vitro and in vivo

6 Novoseek disease relationships for BMPR1B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
brachydactyly, type a2	92.69	2	16127465 (1), 19327734 (1)
pancreatic cancer	6.97	3	10415856 (1), 10449972 (1)
inflammation	0.00	1	12151307 (1)
breast cancer	0.00	2	15892165 (1), 17004110 (1)
tumors	0.00	1	10974075 (1)
prostate cancer	0.00	1	9178898 (1)

About this table

Human Gene Mutation Database: BMPR1B
Genetic Association Database: BMPR1B
Human Genome Epidemiology Navigator: BMPR1B (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/117 PubMed articles for BMPR1B gene (see all 117 ):

Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2. (PubMed id 14523231)^{1, 3, 4} Lehmann K.... Mundlos S. (2003)
Chromosomal localization of three human genes encoding bone morphogenetic protein receptors. (PubMed id 10051328)^{1, 3, 4} Astroem A.-K.... Stenman G. (1999)
Cloning of human bone morphogenetic protein type IB receptor (BMPR- IB) and its expression in prostate cancer in comparison with other BMPRs. (PubMed id 9178898)^{1, 3, 4} Ide H.... Terada M. (1997)
A homozygous BMPR1B mutation causes a new subtype of acromesomelic chondrodysplasia with genital anomalies. (PubMed id 15805157)^{3, 4} Demirhan O.... Lehmann K. (2005)
The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. (PubMed id 15235019)^{3, 6} Howe J.R....Lynch H.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23-->q24 byin situ hybridization and radiation hybrid map ping. (PubMed id 9730621)^{2, 3} Ide H....Terada M. (1998)
Characterization of type I receptors for transforming growth factor-beta and activin. (PubMed id 8140412)^{2, 3} ten Dijke P....Heldin C.H. (1994)
Characterization of the bone morphogenetic protein (BMP) system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary pulmonary hypertension: roles of BMP type IB receptor (activin receptor-like kinase-6) in the mitotic action. (PubMed id 15192043)^{1, 3} Takeda M....Makino H. (2004)
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. (PubMed id 11279102)^{1, 3} Parks W.T.... Lechleider R.J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 658	HGNC: 1077	AceView: BMPR1B	Ensembl:ENSG00000138696	euGenes: HUgn658
ECgene: BMPR1B	H-InvDB: BMPR1B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BMPR1B	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=BMPR1B

Licensable Technologies for BMPR1B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BMPR1B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BMPR1B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BMPR1B		Antibodies for BMPR1B
	Explore super-pooled esiRNAs		Proteins for BMPR1B
	Lentivirus-delivered shRNAs for BMPR1B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BMPR1B)
	Antibodies (BMPR1B)
	Chimera RNAi (BMPR1B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (BMPR1B)
	Antibodies (BMPR1B)

Search OriGene for BMPR1B

Search Tocris compounds for BMPR1B

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BMPR1B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
BMPR1B Gene at Home site.
Version 2.41.1
server4.xennexinc.com

BMPR1B Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for BMPR1B

Summaries
for BMPR1B

Genomic Location
for BMPR1B

Proteins
for BMPR1B

Protein Domains/
Families
for BMPR1B

Gene Function
for BMPR1B

Pathways & Interactions
for BMPR1B

Drugs & Compounds
for BMPR1B

Transcripts
for BMPR1B

Expression
for BMPR1B

Orthologs
for BMPR1B

Paralogs
for BMPR1B

SNPs/Variants
for BMPR1B

Disorders & Mutations
for BMPR1B

Medical News
for BMPR1B

Publications
for BMPR1B

Search for BMPR1B

Genome Databases showing BMPR1B

Other Databases showing BMPR1B

Specialized Databases showing BMPR1B

Licensable Technologies
for BMPR1B

Services
for BMPR1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BMPR1B Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor BMPR1B

Summariesfor BMPR1B

Genomic Locationfor BMPR1B

Proteinsfor BMPR1B

Protein Domains/Familiesfor BMPR1B

Gene Functionfor BMPR1B

Pathways & Interactionsfor BMPR1B

Drugs & Compoundsfor BMPR1B

Transcriptsfor BMPR1B

Expression for BMPR1B

Orthologsfor BMPR1B

Paralogsfor BMPR1B

SNPs/Variantsfor BMPR1B

Disorders & Mutationsfor BMPR1B

Medical Newsfor BMPR1B

Publicationsfor BMPR1B

Search for BMPR1B

Genome Databases showing BMPR1B

Other Databases showing BMPR1B

Specialized Databases showing BMPR1B

Licensable Technologiesfor BMPR1B

Servicesfor BMPR1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BMPR1B

Summaries
for BMPR1B

Genomic Location
for BMPR1B

Proteins
for BMPR1B

Protein Domains/
Families
for BMPR1B

Gene Function
for BMPR1B

Pathways & Interactions
for BMPR1B

Drugs & Compounds
for BMPR1B

Transcripts
for BMPR1B

Expression
for BMPR1B

Orthologs
for BMPR1B

Paralogs
for BMPR1B

SNPs/Variants
for BMPR1B

Disorders & Mutations
for BMPR1B

Medical News
for BMPR1B

Publications
for BMPR1B

Licensable Technologies
for BMPR1B

Services
for BMPR1B