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Aliases & Descriptions for BMPER
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CRIM3 1, 2 | | CV-2 2 | | CV2 2 | | Cv2 1 | | KIAA1965 3 | | crossveinless-2 2 | | hCV2 3 |
| | | Descriptions |
|---|
| BMP binding endothelial regulator 2 | | BMP-binding endothelial regulator precursor protein 2 | Bone morphogenetic protein-binding endothelial cell precursor-derived regulator 2, 3 | | Protein crossveinless-2 3 | | crossveinless 2 2 |
|
| | Search outside databases for aliases for BMPER genePrevious GC identifers: GC07P033653 GC07P033686 GC07P033717 |
Summaries for BMPER(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: BMPER_HUMAN, Q8N8U9Function: Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes |
Genomic Location for BMPER
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p14.3 Ensembl cytogenetic band: 7p14.3 HGNC cytogenetic band: 7p14.3BMPER Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P033911:
(about GC identifiers)
Start:
|
33,911,048 bp from pter |
End:
|
34,162,009 bp from pter |
Size:
|
250,962 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 33,988,876-34,239,892 |
RefSeq DNA sequence:- NC_000007.12 NT_007819.16 NT_079592.2
| Proteins for BMPER
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BMPER_HUMAN, Q8N8U9 (See
protein sequence)Recommended Name: BMP-binding endothelial regulator protein precursor Size: 685 amino acids; 75997 Da
Subunit: Interacts with BMP4 (By similarity)
Subcellular location: Secreted
Secondary accessions: A8K1P8 Q8TF36REFSEQ proteins: NP_597725.1
ENSEMBL proteins: ENSP00000297161
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | About this table
Antibodies for BMPER: Assays for BMPER: | Protein
Domains/ Families for BMPER(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8N8U9
ProtoNet protein and cluster: Q8N8U9 2 Blocks protein families: IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain IPB002919 Trypsin inhibitor-like
UniProtKB/Swiss-Prot: BMPER_HUMAN, Q8N8U9Similarity: Contains 1 TIL (trypsin inhibitory-like) domainSimilarity: Contains 5 VWFC domainsSimilarity: Contains 1 VWFD domain | Gene Function for BMPER
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_166592
Applied Biosystems Silencer® siRNAs for BMPER
Sigma-Aldrich siRNA for BMPER  Sigma-Aldrich shRNA for BMPER  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_133468                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_133468                                  untagged cDNA clones in CMV expression vector (see all 2): NM_133468 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_133468
UniProtKB/Swiss-Prot: BMPER_HUMAN, Q8N8U9Function: Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes12 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Bmper):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for BMPER
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for BMPER 
5/9 Interacting proteins for BMPER (ENSP000002971613) via UniProtKB, MINT, and/or STRING (see all 9
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030514 | negative regulation of BMP signaling pathway |
IEA | -- | About this table
|
Drugs & Compounds for BMPER(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BMPER
|
Transcripts for BMPER(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_166592
Sigma-Aldrich siRNA for BMPER  Sigma-Aldrich shRNA for BMPER  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_133468 REFSEQ mRNAs for BMPER gene: NM_133468.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_133468               OriGene GFP tagged cDNA clone in CMV expression vector: NM_133468                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_133468                                  untagged cDNA clones in CMV expression vector (see all 2): NM_133468  Additional cDNA sequence: AB075845.1 AK289963.1 AY324650.1 BC060868.1 CR609827.1 4 DOTS entries: DT.307586 DT.91835677 DT.95153310 DT.91945627 24/28 AceView cDNA sequences (see all 28
):NM_133468 AA649871 CA449661 BX380517 BC060868 BM907459 CR609827 BQ005555 BX348331 BE743889 BX348332 AB075845 AW779103 AV723284 CB856815 BU689099 BX102594 BX952325 AY324650 AA142989 AI423201 AK096150 BF999553 BF997956
highest scoring ESTs for BMPER:AA142989 AI423201 AA649871 AA730301 AB075845 AW779103 BC060868 BM907459 BM907718 BQ005555 Unigene Cluster for BMPER: BMP binding endothelial regulator Hs.660998 [show with all ESTs]Unigene Representative Sequence: AB075845
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for BMPER
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for BMPER
1 Ensembl transcript including schematic representation: ENST00000297161
|
Expression for BMPER
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BMPER expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BMPER
1 / 2 / 3 4 probe-sets matching BMPER gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TATAAAATGA
SOURCE GeneReport for Unigene cluster: Hs.660998 UniProtKB/Swiss-Prot: BMPER_HUMAN, Q8N8U9Tissue specificity: Highly expressed in lung, and brain and also in primary chondrocytes |
Orthologs for BMPER
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BMPER gene from 5/10 species (see all 10
)
About this table Species with no ortholog for BMPER
ENSEMBL Gene Tree for BMPER | Paralogs for BMPER(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for BMPER gene
- ENSG000001975582 ENSG000002140282
|
SNPs/Variants for BMPER(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BMPER (up to first 250kb)
|
Disorders & Mutations for BMPER
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608699
|
Medical News for BMPER(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BMPER (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for BMPER gene (see all 13
):- Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins. (PubMed id 14766204)1, 2, 3, 4 Binnerts M.E....Rupp F. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. (PubMed id 12897139)2, 3 Moser M....Patterson C. (2003)
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)3, 4 Nagase T....Ohara O. (2001)
- BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. (PubMed id 18787191)3 Heinke J....Moser M. (2008)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)3 Scherer S.W....Tsui L.C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila. (PubMed id 18539121)1 Serpe M....Blair S.S. (2008)
- Crossveinless-2 controls bone morphogenetic protein signaling during early cardiomyocyte differentiation in P19 cells. (PubMed id 18662983)1 Harada K....Oh H. (2008)
|
Search for BMPER
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BMPER
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BMPER
(According to HUGE)
About This Section
| |
Specialized Databases showing BMPER(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BMPER(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BMPER:

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| | | | Search Tocris compounds for BMPER |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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