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BMPER Gene

protein-coding   GIFtS: 51

GC07P033911
BMP binding endothelial regulator
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CRIM3 1, 2
CV-2 2
CV2 2
Cv2 1
KIAA1965 3
crossveinless-2 2
hCV2 3
Descriptions
BMP binding endothelial regulator 2
BMP-binding endothelial regulator precursor protein 2
Bone morphogenetic protein-binding endothelial cell
precursor-derived regulator 2, 3
Protein crossveinless-2 3
crossveinless 2 2
External Ids
HGNC: 241541
Entrez Gene: 1686672
UniProtKB: Q8N8U93
Ensembl: ENSG000001646197
Search outside databases for aliases for BMPER gene

Previous GC identifers: GC07P033653 GC07P033686 GC07P033717

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: BMPER_HUMAN, Q8N8U9
Function: Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP
responsiveness of osteoblasts and chondrocytes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p14.3

BMPER Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P033911:     (about GC identifiers)

Start:
33,911,048 bp from pter
End:
34,162,009 bp from pter
Size:
250,962 bases
Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 33,988,876-34,239,892     
RefSeq DNA sequence:
NC_000007.12  NT_007819.16  NT_079592.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BMPER_HUMAN, Q8N8U9 (See protein sequence)
Recommended Name: BMP-binding endothelial regulator protein precursor  
Size: 685 amino acids; 75997 Da
Subunit: Interacts with BMP4 (By similarity)
Subcellular location: Secreted
Secondary accessions: A8K1P8 Q8TF36

REFSEQ proteins: NP_597725.1  

ENSEMBL proteins: 
ENSP00000297161 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
R&D Systems Recombinant & Natural Proteins for BMPER (Crossveinless-2)
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (BMPER)
Human Recombinant Proteins from Abnova (BMPER)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
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Antibodies for BMPER: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for BMPER
R&D Systems Antibodies for BMPER (Crossveinless-2)
Antibodies from Abcam (BMPER), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for BMPER

Assays for BMPER: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR018453 Prot_Inh_CR_TIL_sg
 IPR014853 Conserved-cysteine-rich_domain
 IPR001007 VWF_C
 IPR001846 von_Willebrand_fac_D


   GeneDecks  BMPER for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8N8U9

ProtoNet protein and cluster: Q8N8U9

2 Blocks protein families:
IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
IPB002919 Trypsin inhibitor-like


UniProtKB/Swiss-Prot: BMPER_HUMAN, Q8N8U9
Similarity: Contains 1 TIL (trypsin inhibitory-like) domain
Similarity: Contains 5 VWFC domains
Similarity: Contains 1 VWFD domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (BMPER)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_166592

              Applied Biosystems Silencer® siRNAs for BMPER

              Sigma-Aldrich siRNA for BMPER  
                     Sigma-Aldrich shRNA for BMPER  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for BMPER
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_133468
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_133468
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_133468 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_133468

UniProtKB/Swiss-Prot: BMPER_HUMAN, Q8N8U9
Function: Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP
responsiveness of osteoblasts and chondrocytes

12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Bmper):

craniofacialembryogenesisgrowth/sizehearing/vestibular/earlethality-prenatal/perinatal
life span-post-weaning/aginglimbs/digits/tailnervous systemrenal/urinary systemrespiratory system
skeletonvision/eye

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  BMPER 


5/9 Interacting proteins for BMPER (ENSP000002971613) via UniProtKB, MINT, and/or STRING (see all 9 )
InteractantInteraction Details
GeneCardExternal ID(s)
BMP2ENSP000003681043STRING (score=.978)
BMP4ENSP000002454513STRING (score=.943)
BMP6ENSP000002831473STRING (score=.872)
INHBAENSP000002422083STRING (score=.761)
BMPR1AENSP000003611073STRING (score=.752)
About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0030514 negative regulation of BMP signaling pathway IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BMPER

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (BMPER)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_166592

              Sigma-Aldrich siRNA for BMPER  
                     Sigma-Aldrich shRNA for BMPER  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_133468  

REFSEQ mRNAs for BMPER gene: 

NM_133468.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_133468  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_133468
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_133468
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_133468 

Additional cDNA sequence: 

AB075845.1 AK289963.1 AY324650.1 BC060868.1 CR609827.1 

4 DOTS entries:

DT.307586  DT.91835677  DT.95153310  DT.91945627 

24/28 AceView cDNA sequences (see all 28 ):

NM_133468 AA649871 CA449661 BX380517 BC060868 BM907459 CR609827 BQ005555 
BX348331 BE743889 BX348332 AB075845 AW779103 AV723284 CB856815 BU689099 
BX102594 BX952325 AY324650 AA142989 AI423201 AK096150 BF999553 BF997956 

highest scoring ESTs for BMPER:

AA142989 AI423201 AA649871 AA730301 AB075845 AW779103 BC060868 BM907459 BM907718 BQ005555 

Unigene Cluster for BMPER:

BMP binding endothelial regulator
Hs.660998  [show with all ESTs]
Unigene Representative Sequence: AB075845


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for BMPER

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:                                                                          -                           
SP2:                                                                                -                     

About this scheme

ECgene alternative splicing isoforms for BMPER

1 Ensembl transcript including schematic representation:
ENST00000297161  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BMPER expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for BMPER

1 / 2 / 3

4 probe-sets matching BMPER gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
85834_at2, 3 U95-D 1 1.00 1.00 0.94 0.92 AI423201 1.00 1.00 1.00 1
55955_at2, 3 U95-B 1 1.00 1.00 0.90 1.10 AA142989 1.00 1.00 1.00 1

241986_at2, 3 U133-B 1 1.00 1.00 -- -- AI423201 1.00 1.00 1.00 1

241986_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  BMPER for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TATAAAATGA

SOURCE GeneReport for Unigene cluster: Hs.660998

UniProtKB/Swiss-Prot: BMPER_HUMAN, Q8N8U9
Tissue specificity: Highly expressed in lung, and brain and also in primary chondrocytes

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for BMPER gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
BMPER1   -- BMP binding endothelial regulator 92.13(n)
95.6(a)
475280  XM_532513.2  XP_532513.2 
chimpanzee
(Pan troglodytes)
BMPER1   -- BMP binding endothelial regulator 99.51(n)
99.56(a)
463344  XM_519036.2  XP_519036.2 
cow
(Bos taurus)
BMPER1   -- BMP binding endothelial regulator 91.73(n)
94.74(a)
534101  XM_001251123.1  XP_001251124.1 
rat
(Rattus norvegicus)
Bmper1   -- BMP-binding endothelial regulator 87.69(n)
93.51(a)
300455  XM_235962.4  XP_235962.4 
mouse
(Mus musculus)
Bmper1, 5 95
BMP-binding endothelial regulator1, 5 87.83(n)1
92.7(a)1
732301  NM_028472.11  NP_082748.11 
 AF4549545  AK0142215  (see all 9)
About this table        Species with no ortholog for BMPER

ENSEMBL Gene Tree for BMPER
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for BMPER gene
ENSG000001975582  ENSG000002140282  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/1106 NCBI SNPs in BMPER are shown (see all 1106 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 408)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 7 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs47233421,2
A,C,F,H33910343(+) ATCATC/TTCTCT 1 -- ng514Minor allele frequency- T:0.45EU EA WA 418
rs20586811,2
C,F,H34160627(+) GATGTA/GAAACA 1 -- ut314Minor allele frequency- G:0.20EU EA WA 420
rs171696671,2
C,F,H34160477(+) CTTGCC/TCTCAT 1 -- ut3111Minor allele frequency- T:0.21NA EU EA WA 980
rs102493201,2
C,F,H34092147(+) AGCTCC/TGGGCC 1 R/W mis1 ese38Minor allele frequency- T:0.01EU EA WA 838
rs14274841,2
F,H33909341(-) CATAAT/CGTGCA 1 -- ng514Minor allele frequency- C:0.02EU EA WA 420
rs119724041,2
F,H34160114(+) CATCTA/GTGTGT 1 -- ut314Minor allele frequency- G:0.07EU EA WA 416
rs20428101,2
H33909370(-) TGATAG/AAATCT 1 -- ng514Minor allele frequency- A:0.00EU EA WA 416
rs7296301,2
H34064215(+) GTCCTC/TTATCA 1 S/F mis1 ese34Minor allele frequency- T:0.00EU EA WA 406
rs102652071,2
A,C,F,H33976471(+) GAGGGC/TGTTGT 1 G/G syn18Minor allele frequency- T:0.38EU EA WA 834
rs69687411,2
C,F,H34159287(+) AAGACC/GTGTGA 1 T/T syn1 ese311Minor allele frequency- G:0.08EU EA WA NA 978
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HapMap Linkage Disequilibrium images for BMPER (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608699

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/13 PubMed articles for BMPER gene (see all 13 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 168667 HGNC: 24154 AceView: BMPER Ensembl:ENSG00000164619 euGenes: HUgn168667
ECgene: BMPER H-InvDB: BMPER
(According to HUGE)
About This Section

HUGE: KIAA1965
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for BMPER:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for BMPER-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for BMPER Antibodies for BMPER
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for BMPER Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search OriGene for BMPER
 Search Tocris compounds for BMPER




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for BMPER

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