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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BMP8B Gene

protein-coding   GIFtS: 60
GCID: GC01M040222

bone morphogenetic protein 8b

(Previous name: bone morphogenetic protein 8 (osteogenic protein 2) )
(Previous symbol: BMP8)
 Explore 8 diseases affiliated with
BMP8B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BMP8B    

Aliases
for BMP8B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Bone Morphogenetic Protein 8b1 2     BMP-82 3
BMP81 2 3 5     BMP-8B2 3
Bone Morphogenetic Protein 8 (Osteogenic Protein 2)1 2     OP22 5
OP-21 3     DJ118J21.1 (Bone Morphogenetic Protein 8 (Osteogenic Protein 2))2
Osteogenic Protein 22 3     

External Ids:    HGNC: 10751   Entrez Gene: 6562   Ensembl: ENSG000001169857   OMIM: 6022845   UniProtKB: P348203   

Export aliases for BMP8B gene to outside databases

Previous GC identifers: GC01M039638 GC01M039639 GC01M039892 GC01M039996 GC01M038342


Summaries
for BMP8B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BMP8B:
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone
growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified
by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.
Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development.
In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone
inductive activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BMP8B_HUMAN, P34820
Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity)

Gene Wiki entry for BMP8B (Bone morphogenetic protein 8b)


Genomic Views
for BMP8B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMP8B gene promoter:
         AML1a   SREBP-1c   HSF1 (long)   NF-kappaB   SREBP-1b   CP2   SREBP-1a   HSF1short   NF-kappaB1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BMP8B promoter sequence
   Search SABiosciences Chromatin IP Primers for BMP8B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP8B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35-p32   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p35-p32

BMP8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP8B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M040222:  view genomic region     (about GC identifiers)

Start:
 40,222,854 bp from pter      End:
 40,254,533 bp from pter
Size:
 31,680 bases      Orientation:
 minus strand

Proteins
for BMP8B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BMP8B_HUMAN, P34820 (See protein sequence)
Recommended Name: Bone morphogenetic protein 8B precursor  
Size: 402 amino acids; 44768 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Secreted
Secondary accessions: Q53ZM7 Q9NUF0

Explore the universe of human proteins at neXtProt for BMP8B: NX_P34820

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P34820

    • BMP8B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001711.2  
    ENSEMBL proteins: 
     ENSP00000361915   ENSP00000380518  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: BMP8B
    OriGene Custom Protein Services for BMP8B 
    GenScript Custom Purified and Recombinant Proteins Services for BMP8B
    Novus Biologicals BMP8B Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BMP8B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--


    BMP8B for ontologies           About GeneDecksing



    BMP8B Antibody Products: 
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    Uscn Antibodies for BMP8B
    ThermoFisher Antibodies for BMP8B

    Assay Products for BMP8B: 
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    Uscn ELISAs and CLIAs for BMP8B

    Protein Domains /
    Families
    for BMP8B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BMP8B for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002405 Inhibin_asu
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P34820

    ProtoNet protein and cluster: P34820

    3 Blocks protein families:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: BMP8B_HUMAN, P34820
    Similarity: Belongs to the TGF-beta family


    Function
    for BMP8B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BMP8B_HUMAN, P34820
    Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
    epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity)

         Summary:  

    During embryonic development, BMP8B as signaling molecule is secreted from the following cells: Extraembryonic Ectoderm Cells in Extraembryonic Ectoderm It affects the following cells: Intraembryonic Epiblast Cells in Epiblast

    BMP8B as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: BMP-induced cells

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMP8B
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP8B (see all 26):
    hsa-miR-219-1-3p hsa-miR-3664-5p hsa-miR-513a-5p hsa-miR-1285 hsa-miR-449a hsa-miR-378b hsa-miR-483-3p hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmid: BMP8B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMP8B (see all 4)
    OriGene shRNA RFP: BMP8B
    OriGene siRNA: BMP8B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP8B

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMP8B (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMP8B
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    Cell Line
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    Search LifeMap BioReagents cell lines for BMP8B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP8B

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0008083growth factor activity IEA--


    BMP8B for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Bmp8btm1Blh for BMP8B
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bmp8b):
     cellular  embryogenesis  endocrine/exocrine gland  growth/size  immune system 
     mortality/aging  reproductive system 

    BMP8B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BMP8B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TGF-beta signaling pathway
    		TGF-beta signaling pathway1.00
    2Basal cell carcinoma
    		Hedgehog signaling pathway0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for BMP8B):
        Hedgehog signaling pathway
    TGF-beta signaling pathway


    BMP8B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BMP8B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for BMP8B (P348202, 3 ENSP000003619154) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WFIKKN1Q96NZ82, 3, ENSP000003247634MINT-8044168 I2D: score=1 STRING: ENSP00000324763
    WFIKKN2Q8TEU82, 3, ENSP000003111844MINT-8044393 I2D: score=1 STRING: ENSP00000311184
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    BMP4P126443, ENSP000002454514I2D: score=1 STRING: ENSP00000245451
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS1460021
    GO:0001503ossification IEA--
    GO:0030154cell differentiation IEA--
    GO:0040007growth IEA--
    GO:0051216cartilage development IEA--


    BMP8B for ontologies           About GeneDecksing



    Drugs & Compounds
    for BMP8B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BMP8B

    1 HMDB Compound for BMP8B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about BMP8B 

    Transcripts
    for BMP8B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BMP8B gene: 
    NM_001720.3  

    Unigene Cluster for BMP8B:

    Bone morphogenetic protein 8b
    Hs.734367  [show with all ESTs]
    Unigene Representative Sequence: AY303955
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372827(uc001cdz.1) ENST00000397360(uc001cea.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: BMP8B
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMP8B
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP8B (see all 26):
    hsa-miR-219-1-3p hsa-miR-3664-5p hsa-miR-513a-5p hsa-miR-1285 hsa-miR-449a hsa-miR-378b hsa-miR-483-3p hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmid: BMP8B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMP8B (see all 4)
    OriGene shRNA RFP: BMP8B
    OriGene siRNA: BMP8B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP8B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMP8B (see all 2)
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    GenScript: all cDNA clones in your preferred vector: BMP8B (NM_001720)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP8B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP8B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BMP8B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat BMP8B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP8B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP8B

    Additional cDNA sequence: 

    AB075489.1 AY303955.1 BC023526.2 BC080618.1 BC108678.1 

    2 DOTS entries:

    DT.75179353  DT.100745277 

    24/62 AceView cDNA sequences (see all 62):

    BQ877793 BQ958141 BC080618 AW752665 BU149638 BU196821 BQ678141 BM728875 
    BQ881528 BQ680708 BQ883060 AY303955 NM_001720 BM714708 AL121254 BQ888513 
    BU739355 CB104652 BI492377 CB141860 CK823239 BC023526 BE677825 BM893553 

    GeneLoc Exon Structure


    Expression
    for BMP8B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BMP8B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BMP8B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TrophoblastExtraembryonic EctodermExtraembryonic Ectoderm CellsExtraembryonic Tissues, Placenta
    TrophoblastTrophoblastTrophoblast CellsExtraembryonic Tissues
    LiverHepatic MesenchymeMesothelial CellsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See BMP8B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BMP8B

    SOURCE GeneReport for Unigene cluster: Hs.734367
        SABiosciences Expression via Pathway-Focused PCR Arrays including BMP8B: 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP8B

    Orthologs
    for BMP8B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for BMP8B gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC7710581 bone morphogenetic protein 8B-like 75.98(n)
    74.41(a)    		   771058  XM_003642583.1  XP_003642631.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 57(a)
    		 1 → many
    		 GL343481.1(256810-275764)
    zebrafish
    (Danio rerio)    		 Actinopterygii bmp8a1 bone morphogenetic protein 8a 63.43(n)
    61.39(a)    		   561963  NM_001044971.1  NP_001038436.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta gbb6
    scw6
    		 screw
    		 28(a)
    23(a)
    		 many ↔ many
    many ↔ many
    		 2R(19739106-19740772)
    2L(19699627-19700968)
    worm
    (Caenorhabditis elegans)    		 Secernentea dbl-16
    tig-26
    		 DPP/BMP-Like family member (dbl-1)
    TransformIng Growth factor beta family member (tig...
    		 25(a)
    24(a)
    		 possible ortholog
    1 ↔ many
    		 V(6758118-6760392)
    V(4726705-4730155)


    ENSEMBL Gene Tree for BMP8B (if available)
    TreeFam Gene Tree for BMP8B (if available) 

    Paralogs
    for BMP8B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BMP8B gene
    GDF52  GDF32  BMP52  GDF62  BMP42  GDF72  GDF22  BMP22  
    BMP102  BMP32  BMP72  GDF102  GDF12  BMP8A2  BMP62  
    6 SIMAP similar genes for BMP8B using alignment to 3 protein entries:     BMP8B_HUMAN (see all proteins):
    BMP8A    BMP7    BMP5    BMP6    BMP2    BMP4

    BMP8B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BMP8B
    PGOHUM00000244681


    Genomic Variants
    for BMP8B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/484 NCBI SNPs in BMP8B are shown (see all 484)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs127603181,2
    		H--40223419(+) CCAGCC/TTGGGC 3 -- int1 ds5001 ese34Minor allele frequency- T:0.00NS EA 416
    rs1807058281,2
    		--40223444(+) GCACAC/TGCTTG 3 -- int1 ds50010--------
    rs1859641911,2
    		--40223486(+) GACTTG/TGTGTT 3 -- int1 ds50010--------
    rs1896349831,2
    		--40223543(+) ATTTGG/TTGACT 3 -- int1 ds50010--------
    rs1818429751,2
    		--40223732(+) CATTCC/TTGGTG 3 -- ds5001 int10--------
    rs1863963721,2
    		--40223748(+) CTAACC/TATGCC 3 -- int1 ds50010--------
    rs1158715081,2
    		--40223773(+) GCACTA/CAAGAT 3 -- int1 ds50011Minor allele frequency- C:0.01NA 120
    rs754749931,2
    		F,--40223777(+) TAAAGA/GTACAG 3 -- ds5001 int11Minor allele frequency- G:0.03EA 120
    rs1157082771,2
    		F,--40223833(+) TTACAA/GTTGCC 3 -- ds5001 int11Minor allele frequency- G:0.03WA 118
    rs1162415411,2
    		--40223883(+) AAATAC/ATAGGA 3 -- int1 ds50011Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for BMP8B (40222854 - 40254533 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for BMP8B
         2 CNVs: 53124 3289

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    Disorders / Diseases
    for BMP8B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BMP8B for disorders           About GeneDecksing

    OMIM gene information: 602284    OMIM disorders: --

    8 diseases for BMP8B:    About MalaCards
    blue color blindness    color blindness    myelofibrosis    achondroplasia
    hepatitis c    blindness    hepatitis    carcinoma

    1 disease from the University of Copenhagen DISEASES database for BMP8B:
    Blue color blindness
    Genetic Association Database (GAD): BMP8B
    Human Genome Epidemiology (HuGE) Navigator: BMP8B (3 documents)

    Export disorders for BMP8B gene to outside databases

    Publications
    for BMP8B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BMP8B gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with BMP8B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Osteogenic protein-2. A new member of the transforming growth factor- beta superfamily expressed early in embryogenesis. (PubMed id 1460021)1, 2, 3, 9 Oezkaynak E.... Oppermann H. (1992)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (2004)
    4. The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4. (PubMed id 9070944)1, 3 DiLeone R.J....Kingsley D.M. (1997)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1 He C....Hunter D.J. (2010)
    7. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    8. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
    9. Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. (PubMed id 16314833)1 Wen X.Z....Yuasa Y. (2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for BMP8B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BMP8B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 656 HGNC: 1075 AceView: BMP8B Ensembl:ENSG00000116985 euGenes: HUgn656
    ECgene: BMP8B Kegg: 656 H-InvDB: BMP8B

    Other Databases showing BMP8B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BMP8B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BMP8B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP8B Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_8b

    Intellectual Property
    for BMP8B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BMP8B gene:
    Search GeneIP for patents involving BMP8B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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