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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BMP8B Gene

protein-coding   GIFtS: 60
GCID: GC01M040222

Bone Morphogenetic Protein 8b

(Previous name: bone morphogenetic protein 8 (osteogenic protein 2))
(Previous symbol: BMP8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bone Morphogenetic Protein 8b1 2     BMP-8B2 3
BMP81 2 3 5     OP22 5
Osteogenic Protein 21 2 3     DJ118J21.1 (Bone Morphogenetic Protein 8 (Osteogenic Protein 2))2
Bone Morphogenetic Protein 8 (Osteogenic Protein 2)1 2     OP-23
BMP-82 3     

External Ids:    HGNC: 10751   Entrez Gene: 6562   Ensembl: ENSG000001169857   OMIM: 6022845   UniProtKB: P348203   

Export aliases for BMP8B gene to outside databases

Previous GC identifers: GC01M039638 GC01M039639 GC01M039892 GC01M039996 GC01M038342


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BMP8B Gene:
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone
growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally
identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an
extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed
role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to
speculation of possible bone inductive activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for BMP8B Gene: 
BMP8B (bone morphogenetic protein 8b) is a protein-coding gene. Diseases associated with BMP8B include blue color blindness, and color blindness. GO annotations related to this gene include growth factor activity and cytokine activity. An important paralog of this gene is GDF5.

UniProtKB/Swiss-Prot: BMP8B_HUMAN, P34820
Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity)

Gene Wiki entry for BMP8B (Bone morphogenetic protein 8b) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMP8B gene promoter:
         AML1a   SREBP-1c   HSF1 (long)   NF-kappaB   SREBP-1b   CP2   SREBP-1a   HSF1short   NF-kappaB1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP8B promoter sequence
   Search SABiosciences Chromatin IP Primers for BMP8B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP8B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35-p32   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p35-p32

BMP8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP8B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M040222:  view genomic region     (about GC identifiers)

Start:
40,222,854 bp from pter      End:
40,254,533 bp from pter
Size:
31,680 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BMP8B_HUMAN, P34820 (See protein sequence)
Recommended Name: Bone morphogenetic protein 8B precursor  
Size: 402 amino acids; 44768 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: Q53ZM7 Q9NUF0

Explore the universe of human proteins at neXtProt for BMP8B: NX_P34820

Explore proteomics data for BMP8B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P34820

  • BMP8B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BMP8B Protein Expression
    REFSEQ proteins: NP_001711.2  
    ENSEMBL proteins: 
     ENSP00000361915   ENSP00000380518  

    Human Recombinant Protein Products for BMP8B: 
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    Novus Biologicals BMP8B Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BMP8B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    BMP8B for ontologies           About GeneDecksing



    BMP8B Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for BMP8B 

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    Cloud-Clone Corp. ELISAs for BMP8B 
    Cloud-Clone Corp. CLIAs for BMP8B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BMP: Bone morphogenetic proteins

    5 InterPro protein domains:
     IPR002405 Inhibin_asu
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P34820

    ProtoNet protein and cluster: P34820

    3 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: BMP8B_HUMAN, P34820
    Similarity: Belongs to the TGF-beta family


    BMP8B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP8B_HUMAN, P34820
    Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
    epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity)

         Summary:

    During embryonic development, BMP8B as signaling molecule is secreted from the following cells: Extraembryonic Ectoderm Cells in Extraembryonic Ectoderm It affects the following cells: Intraembryonic Epiblast Cells in Epiblast

    BMP8B as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: BMP-induced cells from

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0008083growth factor activity IEA--
         
    BMP8B for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bmp8b):
     cellular  embryogenesis  endocrine/exocrine gland  growth/size  immune system 
     mortality/aging  reproductive system 

    BMP8B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bmp8btm1Blh for BMP8B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BMP8B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BMP8B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BMP8B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BMP8B 

    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP8B (see all 26):
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    SwitchGear 3'UTR luciferase reporter plasmidBMP8B 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP8B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BMP8B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hippo signaling pathway
    Hippo signaling pathway
    2TGF-beta signaling pathway
    TGF-beta signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for BMP8B):
        TGF-beta signaling pathway
    Hippo signaling pathway


    BMP8B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BMP8B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for BMP8B (P348202, 3 ENSP000003619154) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WFIKKN1Q96NZ82, 3, ENSP000003247634MINT-8044168 I2D: score=1 STRING: ENSP00000324763
    WFIKKN2Q8TEU82, 3, ENSP000003111844MINT-8044393 I2D: score=1 STRING: ENSP00000311184
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    BMP4P126443, ENSP000002454514I2D: score=1 STRING: ENSP00000245451
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS1460021
    GO:0001503ossification IEA--
    GO:0030154cell differentiation IEA--
    GO:0040007growth IEA--
    GO:0051216cartilage development IEA--

    BMP8B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BMP8B

    1 HMDB Compound for BMP8B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about BMP8B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BMP8B gene: 
    NM_001720.3  

    Unigene Cluster for BMP8B:

    Bone morphogenetic protein 8b
    Hs.734367  [show with all ESTs]
    Unigene Representative Sequence: AY303955
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372827(uc001cdz.1) ENST00000397360(uc001cea.1)
    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP8B (see all 26):
    hsa-miR-219-1-3p hsa-miR-3664-5p hsa-miR-513a-5p hsa-miR-1285 hsa-miR-449a hsa-miR-378b hsa-miR-483-3p hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidBMP8B 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP8B
    Clone
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    OriGene ORF clones in mouse, rat for BMP8B
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP8B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP8B
    Sirion Biotech Customized lentivirus for stable overexpression of BMP8B 
                         Customized lentivirus expression plasmids for stable overexpression of BMP8B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for BMP8B
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP8B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP8B

    Additional mRNA sequence: 

    AB075489.1 AY303955.1 BC023526.2 BC080618.1 BC108678.1 

    2 DOTS entries:

    DT.75179353  DT.100745277 

    24/62 AceView cDNA sequences (see all 62):

    BM728875 AL121254 BC080618 BU196821 AW752665 BQ680708 CB141860 BQ883060 
    BQ877793 BU149638 BQ678141 NM_001720 BQ888513 BU739355 AY303955 BQ958141 
    BI492377 BM714708 CB104652 BQ881528 AI308752 BV199142 BF439463 BU943744 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BMP8B expression in normal human tissues (normalized intensities)      BMP8B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BMP8B Expression
    About this image


    BMP8B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Peripheral Nervous System (Nervous System)
             dorsal root ganglia   
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See BMP8B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BMP8B

    SOURCE GeneReport for Unigene cluster: Hs.734367
        SABiosciences Expression via Pathway-Focused PCR Arrays including BMP8B: 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP8B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BMP8B gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp8b5
    Bmp8a1
    bone morphogenetic protein 8b5
    bone morphogenetic protein 8a1
    86.05(n)1
    86.22(a)1
      4 (57.38 cM)5
    121631  NM_007558.31  NP_031584.11 
     1231051655 
    chicken
    (Gallus gallus)
    Aves LOC7710581 bone morphogenetic protein 8B-like 75.98(n)
    74.41(a)
      771058  XM_003642583.1  XP_003642631.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    60(a)
    1 → many
    GL343481.1(256810-275764)
    zebrafish
    (Danio rerio)
    Actinopterygii bmp8a1 bone morphogenetic protein 8a 63.43(n)
    61.39(a)
      561963  NM_001044971.1  NP_001038436.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gbb6
    scw6
    screw
    29(a)
    26(a)
    many ↔ many
    many ↔ many
    2R(19739106-19740772)
    2L(19699627-19700968)


    ENSEMBL Gene Tree for BMP8B (if available)
    TreeFam Gene Tree for BMP8B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BMP8B gene
    GDF52  BMP52  GDF32  GDF62  BMP42  GDF72  GDF22  BMP22  
    BMP102  BMP32  BMP72  GDF102  GDF12  BMP8A2  BMP62  
    4 SIMAP similar genes for BMP8B using alignment to 3 protein entries:     BMP8B_HUMAN (see all proteins):
    BMP8A    BMP7    BMP5    BMP6

    BMP8B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BMP8B
    PGOHUM00000244681


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/399 SNPs in BMP8B are shown (see all 399)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0144744
    ----see VAR_0144742 H R mis40--------
    rs1469132541,2
    F--40230302(+) AAGATC/GCCTGG 2 G syn11Minor allele frequency- G:0.00NA 4450
    rs1432862251,2
    C,F--40230331(+) CAGCTC/TGTTGC 2 K E mis12Minor allele frequency- T:0.00NA EU 5837
    rs763762261,2
    C--40230336(+) CGTTGC/GTTTTC 2 T S mis10--------
    rs1998060171,2
    C--40230385(+) GGTGCG/AGATGG 2 /R /C mis11Minor allele frequency- A:0.00EU 1317
    rs1911550591,2
    C--40230527(+) GGCAGT/CGGCCC 1 -- int11Minor allele frequency- C:0.00EU 497
    rs1157054831,2
    C,F--40230531(+) GTGGCC/TCTGCA 1 -- int13Minor allele frequency- T:0.10NA EA EU 771
    rs1836594491,2
    --40230919(+) AGGACC/GCCGAG 1 -- int10--------
    rs2021386111,2
    C--40231971(+) AACAGA/TGCCAG 1 -- int10--------
    rs1475010911,2
    C--40232049(+) ACACAG/TGCATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for BMP8B (40222854 - 40254533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for BMP8B:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv215n71CNV Loss21882294
    nsv871927CNV Loss21882294
    dgv15n27CNV Gain19166990
    dgv49e1CNV Complex17122850
    nsv7177OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602284    OMIM disorders: --

    7 diseases for BMP8B:    About MalaCards
    blue color blindness    color blindness    achondroplasia    myelofibrosis
    blindness    hepatitis c    hepatitis

    1 disease from the University of Copenhagen DISEASES database for BMP8B:
    Blue color blindness

    BMP8B for disorders           About GeneDecksing

    Genetic Association Database (GAD): BMP8B
    Human Genome Epidemiology (HuGE) Navigator: BMP8B (3 documents)

    Export disorders for BMP8B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BMP8B gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with BMP8B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Osteogenic protein-2. A new member of the transforming growth factor- beta superfamily expressed early in embryogenesis. (PubMed id 1460021)1, 2, 3, 9 Oezkaynak E.... Oppermann H. (1992)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (2004)
    6. The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4. (PubMed id 9070944)1, 3 DiLeone R.J....Kingsley D.M. (1997)
    7. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    8. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (2007)
    9. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
    10. Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. (PubMed id 16314833)1 Wen X.Z....Yuasa Y. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 656 HGNC: 1075 AceView: BMP8B Ensembl:ENSG00000116985 euGenes: HUgn656
    ECgene: BMP8B Kegg: 656 H-InvDB: BMP8B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BMP8B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP8B Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_8b

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BMP8B gene:
    Search GeneIP for patents involving BMP8B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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