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Aliases for BMP8A Gene

Aliases for BMP8A Gene

  • Bone Morphogenetic Protein 8a 2 3
  • BMP-8A 3 4

External Ids for BMP8A Gene

Summaries for BMP8A Gene

GeneCards Summary for BMP8A Gene

BMP8A (Bone Morphogenetic Protein 8a) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include cytokine activity and growth factor activity. An important paralog of this gene is BMP2.

UniProtKB/Swiss-Prot for BMP8A Gene

  • Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.

Gene Wiki entry for BMP8A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP8A Gene

Genomics for BMP8A Gene

Genomic Location for BMP8A Gene

Start:
39,491,646 bp from pter
End:
39,529,869 bp from pter
Size:
38,224 bases
Orientation:
Plus strand

Genomic View for BMP8A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMP8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP8A Gene

Regulatory Elements for BMP8A Gene

Proteins for BMP8A Gene

  • Protein details for BMP8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5Y6-BMP8A_HUMAN
    Recommended name:
    Bone morphogenetic protein 8A
    Protein Accession:
    Q7Z5Y6
    Secondary Accessions:
    • Q5T3A5

    Protein attributes for BMP8A Gene

    Size:
    402 amino acids
    Molecular mass:
    44798 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for BMP8A Gene

Proteomics data for BMP8A Gene at MOPED

Post-translational modifications for BMP8A Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn158 and Asn343

Other Protein References for BMP8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BMP8A Gene

Domains for BMP8A Gene

Gene Families for BMP8A Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • BMP :Bone morphogenetic proteins

UniProtKB/Swiss-Prot:

BMP8A_HUMAN
Family:
  • Belongs to the TGF-beta family.:
    • Q7Z5Y6
genes like me logo Genes that share domains with BMP8A: view

Function for BMP8A Gene

Molecular function for BMP8A Gene

UniProtKB/Swiss-Prot Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.

Gene Ontology (GO) - Molecular Function for BMP8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0008083 growth factor activity IEA --
GO:0070700 BMP receptor binding IBA --
genes like me logo Genes that share ontologies with BMP8A: view
genes like me logo Genes that share phenotypes with BMP8A: view

Animal Models for BMP8A Gene

MGI Knock Outs for BMP8A:

miRNA for BMP8A Gene

miRTarBase miRNAs that target BMP8A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BMP8A Gene

Localization for BMP8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP8A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BMP8A Gene COMPARTMENTS Subcellular localization image for BMP8A gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BMP8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with BMP8A: view

Pathways for BMP8A Gene

genes like me logo Genes that share pathways with BMP8A: view

Pathways by source for BMP8A Gene

Interacting Proteins for BMP8A Gene

Gene Ontology (GO) - Biological Process for BMP8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0002024 diet induced thermogenesis IDA 22579288
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
GO:0030154 cell differentiation --
GO:0030509 BMP signaling pathway IBA --
genes like me logo Genes that share ontologies with BMP8A: view

Compounds for BMP8A Gene

(1) HMDB Compounds for BMP8A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with BMP8A: view

Transcripts for BMP8A Gene

mRNA/cDNA for BMP8A Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BMP8A Gene

Bone morphogenetic protein 8a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BMP8A Gene

No ASD Table

Relevant External Links for BMP8A Gene

GeneLoc Exon Structure for
BMP8A
ECgene alternative splicing isoforms for
BMP8A

Expression for BMP8A Gene

mRNA expression in normal human tissues for BMP8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BMP8A Gene

This gene is overexpressed in Thyroid (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BMP8A Gene

SOURCE GeneReport for Unigene cluster for BMP8A Gene Hs.472497

genes like me logo Genes that share expressions with BMP8A: view

Orthologs for BMP8A Gene

This gene was present in the common ancestor of chordates.

Orthologs for BMP8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BMP8A 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 88 (a)
ManyToMany
-- 37
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 89 (a)
ManyToMany
-- 37
  • 84 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Bmp8a 36
  • 85.05 (n)
  • 84.96 (a)
Bmp8a 16
Bmp8a 37
  • 83 (a)
ManyToMany
Bmp8b 37
  • 75 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Bmp8a 36
  • 84.8 (n)
  • 85.71 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii bmp8a 37
  • 50 (a)
OneToMany
Species with no ortholog for BMP8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BMP8A Gene

ENSEMBL:
Gene Tree for BMP8A (if available)
TreeFam:
Gene Tree for BMP8A (if available)

Paralogs for BMP8A Gene

Paralogs for BMP8A Gene

Selected SIMAP similar genes for BMP8A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BMP8A: view

Variants for BMP8A Gene

Sequence variations from dbSNP and Humsavar for BMP8A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs569332 -- 39,515,924(+) ACTTC(A/G)TCAGT intron-variant
rs698138 -- 39,516,752(-) GTAAA(C/G)ATCAC intron-variant
rs698139 -- 39,516,936(+) GTTTG(C/T)GATTG intron-variant
rs698141 -- 39,500,089(-) GGGGC(C/T)GAGGT intron-variant
rs709211 -- 39,518,203(+) GGCCA(C/T)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BMP8A Gene

Variant ID Type Subtype PubMed ID
nsv870829 CNV Gain 21882294
nsv871499 CNV Loss 21882294
nsv7177 OTHER Inversion 18451855
nsv870462 CNV Loss 21882294
esv2268423 CNV Deletion 18987734
nsv508160 CNV Loss 20534489
esv1368683 CNV Insertion 17803354
nsv829649 CNV Loss 17160897

Relevant External Links for BMP8A Gene

HapMap Linkage Disequilibrium report
BMP8A

Disorders for BMP8A Gene

Relevant External Links for BMP8A

Genetic Association Database (GAD)
BMP8A
Human Genome Epidemiology (HuGE) Navigator
BMP8A
genes like me logo Genes that share disorders with BMP8A: view

No data available for UniProtKB/Swiss-Prot for BMP8A Gene

Publications for BMP8A Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 49
  3. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. (PMID: 22579288) Whittle A.J. … Vidal-Puig A. (Cell 2012) 3 4
  4. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 49
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3

Products for BMP8A Gene

Sources for BMP8A Gene

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