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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BMP8A Gene

protein-coding   GIFtS: 54
GCID: GC01P039958

Bone Morphogenetic Protein 8a

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bone Morphogenetic Protein 8a1 2
BMP-8A2 3

External Ids:    HGNC: 216501   Entrez Gene: 3535002   Ensembl: ENSG000001836827   UniProtKB: Q7Z5Y63   

Export aliases for BMP8A gene to outside databases

Previous GC identifers: GC01U900417 GC01P039371 GC01P039372 GC01P039626 GC01P039731 GC01P038076


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for BMP8A Gene: 
BMP8A (bone morphogenetic protein 8a) is a protein-coding gene. Diseases associated with BMP8A include hyperparathyroidism, and hepatitis c, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include growth factor activity and cytokine activity. An important paralog of this gene is GDF5.

UniProtKB/Swiss-Prot: BMP8A_HUMAN, Q7Z5Y6
Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling
protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response
of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase
sympathetic output to BAT

Gene Wiki entry for BMP8A (Bone morphogenetic protein 8A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMP8A gene promoter:
         p53   Pax-5   Bach2   Evi-1   AREB6   Nkx6-1   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP8A promoter sequence
   Search SABiosciences Chromatin IP Primers for BMP8A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p35-p32

BMP8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP8A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P039958:  view genomic region     (about GC identifiers)

Start:
39,957,318 bp from pter      End:
39,995,541 bp from pter
Size:
38,224 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BMP8A_HUMAN, Q7Z5Y6 (See protein sequence)
Recommended Name: Bone morphogenetic protein 8A precursor  
Size: 402 amino acids; 44798 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Secreted (Probable)
Caution: Experiments with human recombinant protein (in mouse system by intracerebroventricular treatment) are
reported for BMP8B but the protein is corresponding to BMP8A according sequence data provided by the supplier;
related experiments with Bmp8b-/- mice show similar results (PubMed:22579288)
Secondary accessions: Q5T3A5

Explore the universe of human proteins at neXtProt for BMP8A: NX_Q7Z5Y6

Explore proteomics data for BMP8A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z5Y6

  • BMP8A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BMP8A Protein Expression
    REFSEQ proteins: NP_861525.2  
    ENSEMBL proteins: 
     ENSP00000327440  

    Human Recombinant Protein Products for BMP8A: 
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    Novus Biologicals BMP8A Proteins
    Novus Biologicals BMP8A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BMP8A 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    BMP8A for ontologies           About GeneDecksing



    BMP8A Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for BMP8A 

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    Cloud-Clone Corp. ELISAs for BMP8A 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BMP: Bone morphogenetic proteins

    5 InterPro protein domains:
     IPR002405 Inhibin_asu
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry Q7Z5Y6

    ProtoNet protein and cluster: Q7Z5Y6

    2 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)


    UniProtKB/Swiss-Prot: BMP8A_HUMAN, Q7Z5Y6
    Similarity: Belongs to the TGF-beta family


    BMP8A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP8A_HUMAN, Q7Z5Y6
    Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
    epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling
    protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response
    of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase
    sympathetic output to BAT

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0008083growth factor activity IEA--
         
    BMP8A for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bmp8a):
     cellular  endocrine/exocrine gland  immune system  reproductive system 

    BMP8A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bmp8atm1Blh for BMP8A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BMP8A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BMP8A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BMP8A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BMP8A 

    miRNA
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    hsa-miR-3671 hsa-miR-668 hsa-miR-4286 hsa-miR-3194-5p hsa-miR-551b* hsa-miR-4298 hsa-miR-1302 hsa-miR-214
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of BMP8A

    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP8A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BMP8A About   (see all 15)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BMP8A (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer


    2         Kegg Pathways  (Kegg details for BMP8A):
        TGF-beta signaling pathway
    Hippo signaling pathway


    BMP8A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BMP8A

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for BMP8A (Q7Z5Y62 ENSP000003274404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMHR2ENSP000002578634STRING: ENSP00000257863
    BMPR2ENSP000003637084STRING: ENSP00000363708
    CHRDENSP000002046044STRING: ENSP00000204604
    NOGENSP000003281814STRING: ENSP00000328181
    --P310162MINT-8108894
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0002024diet induced thermogenesis IDA--
    GO:0030154cell differentiation IEA--
    GO:0040007growth IEA--
    GO:0046676negative regulation of insulin secretion IDA--

    BMP8A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BMP8A

    1 HMDB Compound for BMP8A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about BMP8A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BMP8A gene: 
    NM_181809.3  

    Unigene Cluster for BMP8A:

    Bone morphogenetic protein 8a
    Hs.472497  [show with all ESTs]
    Unigene Representative Sequence: NM_181809
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331593(uc001cdi.3)
    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP8A (see all 11):
    hsa-miR-3671 hsa-miR-668 hsa-miR-4286 hsa-miR-3194-5p hsa-miR-551b* hsa-miR-4298 hsa-miR-1302 hsa-miR-214
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    GenScript: all cDNA clones in your preferred vector: BMP8A (NM_181809)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP8A
    Sirion Biotech Customized lentivirus for stable overexpression of BMP8A 
                         Customized lentivirus expression plasmids for stable overexpression of BMP8A 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP8A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP8A

    Additional mRNA sequence: 

    AK024413.1 AK127199.1 AY303954.1 BC112044.1 BC131617.1 

    6 DOTS entries:

    DT.75184515  DT.95259662  DT.40311865  DT.75179353  DT.87016349  DT.97787768 

    7 AceView cDNA sequences:

    BV199143 BX279531 BV190153 BX093238 NM_181809 AY303954 AA609425 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BMP8A expression in normal human tissues (normalized intensities)      BMP8A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGCTGAA
    BMP8A Expression
    About this image


    BMP8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Gut Tube (Gastrointestinal Tract)
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End

    See BMP8A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BMP8A

    SOURCE GeneReport for Unigene cluster: Hs.472497
        SABiosciences Custom PCR Arrays for BMP8A
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP8A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BMP8A gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp8a5 bone morphogenetic protein 8a   --   4 (57.42 cM) 123312645 
    chicken
    (Gallus gallus)
    Aves --
    --
    65(a)
    1 → many
    23(5408458-5415669)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    60(a)
    1 → many
    GL343481.1(256810-275764)
    zebrafish
    (Danio rerio)
    Actinopterygii bmp8a6
    bone morphogenetic protein 8a
    50(a)
    1 → many
    19(36567664-36584217)
    fruit fly
    (Drosophila melanogaster)
    Insecta gbb6
    scw6
    screw
    29(a)
    26(a)
    many ↔ many
    many ↔ many
    2R(19739106-19740772)
    2L(19699627-19700968)


    ENSEMBL Gene Tree for BMP8A (if available)
    TreeFam Gene Tree for BMP8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BMP8A gene
    GDF52  BMP52  GDF32  BMP8B2  GDF62  BMP42  GDF72  GDF22  
    BMP22  BMP102  BMP32  BMP72  GDF102  GDF12  BMP62  
    11 SIMAP similar genes for BMP8A using alignment to 3 protein entries:     BMP8A_HUMAN (see all proteins):
    BMP8B    BMP7    NODAL    BMP6    BMP5    TGFB1
    DKFZp686A06204    GDF5    BMP2    BMPY    BMP4

    BMP8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/515 SNPs in BMP8A are shown (see all 515)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0525714
    ----see VAR_0525712 R H mis40--------
    rs10683041,2
    C,H--39955363(-) CCTCTC/GTGCAC 1 -- us2k16Minor allele frequency- G:0.00NS EA NA 422
    rs740693281,2
    C,F--39955463(+) TTTCTC/ACTCTG 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1499170151,2
    --39955554(+) CAGGGC/TCCTGA 1 -- us2k10--------
    rs1869032631,2
    --39955620(+) ACTTTA/CAACGG 1 -- us2k10--------
    rs120444361,2
    C--39955678(+) TCCGCA/GGGGTA 1 -- us2k13Minor allele frequency- G:0.27NA EA 124
    rs1906117141,2
    --39955690(+) CCCCGG/TCTTCT 1 -- us2k10--------
    rs7109191,2
    C,F,H--39955714(-) GAGCAG/CATGTG 1 -- us2k110Minor allele frequency- C:0.10EA NA NS WA 564
    rs29326401,2
    C,F,H--39955901(-) CATTTA/G/TGAAGT 1 -- us2k17NS NA WA CSA 207
    rs113517731,2
    C--39955910(+) TGTGAT/-TTTTG 1 -- us2k11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for BMP8A (39957318 - 39995541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for BMP8A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2268423CNV Deletion18987734
    esv1368683CNV Insertion17803354
    nsv508160CNV Loss20534489
    nsv870462CNV Loss21882294
    nsv871499CNV Loss21882294
    nsv829649CNV Loss17160897
    nsv870829CNV Gain21882294
    nsv7177OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    8 diseases for BMP8A:    About MalaCards
    hyperparathyroidism    hepatitis c    hepatitis b    hepatitis
    hepatocellular carcinoma    adenocarcinoma    pancreatitis    breast cancer


    BMP8A for disorders           About GeneDecksing

    Genetic Association Database (GAD): BMP8A
    Human Genome Epidemiology (HuGE) Navigator: BMP8A (2 documents)

    Export disorders for BMP8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BMP8A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with BMP8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. (PubMed id 22579288)2 Whittle A.J.... Vidal-Puig A. (2012)
    4. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    5. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    6. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    10. Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: Preliminary study. (PubMed id 18959789)9 Zekri A.R....Khaled H.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 353500 HGNC: 21650 AceView: BMP8A Ensembl:ENSG00000183682 euGenes: HUgn353500
    ECgene: BMP8A Kegg: 353500 H-InvDB: BMP8A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BMP8A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_8A

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BMP8A gene:
    Search GeneIP for patents involving BMP8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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