Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BMP8A Gene

protein-coding   GIFtS: 55
GCID: GC01P039958

Bone Morphogenetic Protein 8a

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Bone Morphogenetic Protein 8a1 2
BMP-8A2 3

External Ids:    HGNC: 216501   Entrez Gene: 3535002   Ensembl: ENSG000001836827   UniProtKB: Q7Z5Y63   

Export aliases for BMP8A gene to outside databases

Previous GC identifers: GC01U900417 GC01P039371 GC01P039372 GC01P039626 GC01P039731 GC01P038076


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for BMP8A Gene:
BMP8A (bone morphogenetic protein 8a) is a protein-coding gene. GO annotations related to this gene include growth factor activity and cytokine activity. An important paralog of this gene is GDF5.

UniProtKB/Swiss-Prot: BMP8A_HUMAN, Q7Z5Y6
Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling
protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response
of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase
sympathetic output to BAT

Gene Wiki entry for BMP8A (Bone morphogenetic protein 8A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BMP8A gene promoter:
         p53   Pax-5   Bach2   Evi-1   AREB6   Nkx6-1   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP8A promoter sequence
   Search Chromatin IP Primers for BMP8A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMP8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p35-p32

BMP8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP8A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P039958:  view genomic region     (about GC identifiers)

Start:
39,957,318 bp from pter      End:
39,995,541 bp from pter
Size:
38,224 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BMP8A_HUMAN, Q7Z5Y6 (See protein sequence)
Recommended Name: Bone morphogenetic protein 8A precursor  
Size: 402 amino acids; 44798 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Caution: Experiments with human recombinant protein (in mouse system by intracerebroventricular treatment) are
reported for BMP8B but the protein is corresponding to BMP8A according sequence data provided by the supplier;
related experiments with Bmp8b-/- mice show similar results (PubMed:22579288)
Secondary accessions: Q5T3A5

Explore the universe of human proteins at neXtProt for BMP8A: NX_Q7Z5Y6

Explore proteomics data for BMP8A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn158, Asn343
  • Modification sites at PhosphoSitePlus

  • See BMP8A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_861525.2  
    ENSEMBL proteins: 
     ENSP00000327440  

    BMP8A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for BMP8A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for BMP8A
    GenScript Custom Purified and Recombinant Proteins Services for BMP8A
    Novus Biologicals BMP8A Proteins
    Novus Biologicals BMP8A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BMP8A

     
    Search eBioscience for Proteins for BMP8A 

    BMP8A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for BMP8A (BMP-8)
    OriGene Antibodies for BMP8A
    OriGene Custom Antibody Services for BMP8A
    Novus Biologicals BMP8A Antibodies
    Abcam antibodies for BMP8A
    Cloud-Clone Corp. Antibodies for BMP8A
    Search ThermoFisher Antibodies for BMP8A
    LSBio Antibodies in human, mouse, rat for BMP8A

    BMP8A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BMP8A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BMP8A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BMP8A
    Cloud-Clone Corp. CLIAs for BMP8A
    Search eBioscience for ELISAs for BMP8A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    BMP: Bone morphogenetic proteins

    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR002405 Inhibin_asu
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry Q7Z5Y6

    ProtoNet protein and cluster: Q7Z5Y6

    2 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)


    UniProtKB/Swiss-Prot: BMP8A_HUMAN, Q7Z5Y6
    Similarity: Belongs to the TGF-beta family


    Find genes that share domains with BMP8A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP8A_HUMAN, Q7Z5Y6
    Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
    epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling
    protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response
    of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase
    sympathetic output to BAT

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with BMP8A           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bmp8a):
     cellular  endocrine/exocrine gland  immune system  reproductive system 

    Find genes that share phenotypes with BMP8A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bmp8atm1Blh for BMP8A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BMP8A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BMP8A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BMP8A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BMP8A

    miRNA
    Products:
        
    miRTarBase miRNAs that target BMP8A:
    hsa-mir-142-3p (MIRT021585)

    Block miRNA regulation of human, mouse, rat BMP8A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMP8A (see all 11):
    hsa-miR-3671 hsa-miR-668 hsa-miR-4286 hsa-miR-3194-5p hsa-miR-551b* hsa-miR-4298 hsa-miR-1302 hsa-miR-214
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BMP8A
    Predesigned siRNA for gene silencing in human, mouse, rat BMP8A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BMP8A

    Clone
    Products:
         
    OriGene clones in human, mouse for BMP8A (see all 7)
    OriGene ORF clones in mouse, rat for BMP8A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP8A (NM_181809)
    Sino Biological Human cDNA Clone for BMP8A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP8A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BMP8A
    Browse ESI BIO Cell Lines and PureStem Progenitors for BMP8A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP8A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BMP8A_HUMAN, Q7Z5Y6: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with BMP8A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for BMP8A About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51


    Find genes that share SuperPaths with BMP8A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BMP8A (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer



    2 Kegg Pathways  (Kegg details for BMP8A):
        TGF-beta signaling pathway
    Hippo signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BMP8A
    Interactions:

        Search GeneGlobe Interaction Network for BMP8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for BMP8A (Q7Z5Y62 ENSP000003274404) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMHR2ENSP000002578634STRING: ENSP00000257863
    BMPR2ENSP000003637084STRING: ENSP00000363708
    CHRDENSP000002046044STRING: ENSP00000204604
    NOGENSP000003281814STRING: ENSP00000328181
    FSTENSP000002567594STRING: ENSP00000256759
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0002024diet induced thermogenesis IDA--
    GO:0030154cell differentiation IEA--
    GO:0040007growth IEA--
    GO:0046676negative regulation of insulin secretion IDA--

    Find genes that share ontologies with BMP8A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BMP8A

    1 HMDB Compound for BMP8A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BMP8A gene: 
    NM_181809.3  

    Unigene Cluster for BMP8A:

    Bone morphogenetic protein 8a
    Hs.472497  [show with all ESTs]
    Unigene Representative Sequence: NM_181809
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331593(uc001cdi.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BMP8A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMP8A (see all 11):
    hsa-miR-3671 hsa-miR-668 hsa-miR-4286 hsa-miR-3194-5p hsa-miR-551b* hsa-miR-4298 hsa-miR-1302 hsa-miR-214
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BMP8A
    Predesigned siRNA for gene silencing in human, mouse, rat BMP8A
    Clone
    Products:
         
    OriGene clones in human, mouse for BMP8A (see all 7)
    OriGene ORF clones in mouse, rat for BMP8A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP8A (NM_181809)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP8A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BMP8A
    OriGene qSTAR qPCR primer pairs in human, mouse for BMP8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BMP8A
      QuantiTect SYBR Green Assays in human, mouse, rat BMP8A
      QuantiFast Probe-based Assays in human, mouse, rat BMP8A

    Additional mRNA sequence: 

    AK024413.1 AK127199.1 AY303954.1 BC112044.1 BC131617.1 

    6 DOTS entries:

    DT.75184515  DT.95259662  DT.40311865  DT.75179353  DT.87016349  DT.97787768 

    7 AceView cDNA sequences:

    AY303954 BX279531 BV199143 NM_181809 BX093238 BV190153 AA609425 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BMP8A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGCTGAA
    BMP8A Expression
    About this image


    BMP8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Epithelial Cells
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     Hair (Integumentary System)    fully expand to see all 2 entries
             Fetal Inner Root Sheath Cells Inner Root Sheath
     
     NULL (Uncategorized)
             Endoderm progenitor-like cells
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
    BMP8A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BMP8A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.472497
        Custom PCR Arrays for BMP8A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BMP8A
    OriGene qSTAR qPCR primer pairs in human, mouse for BMP8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BMP8A
    QuantiTect SYBR Green Assays in human, mouse, rat BMP8A
    QuantiFast Probe-based Assays in human, mouse, rat BMP8A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for BMP8A gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp8a1 , 5 bone morphogenetic protein 8a1, 5 85.05(n)1
    84.96(a)1
      4 (57.42 cM)5
    121631  NM_001256019.11  NP_001242948.11 
     1233126455 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    67(a)
    1 → many
    23(5408458-5415669)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    60(a)
    1 → many
    GL343481.1(256810-275764)
    zebrafish
    (Danio rerio)
    Actinopterygii bmp8a6
    bone morphogenetic protein 8a
    50(a)
    1 → many
    19(36567664-36584217) ENSDARG00000035677


    ENSEMBL Gene Tree for BMP8A (if available)
    TreeFam Gene Tree for BMP8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BMP8A gene
    GDF52  BMP52  GDF32  BMP8B2  GDF62  BMP42  GDF72  GDF22  
    BMP22  BMP102  BMP72  GDF12  BMP62  
    11 SIMAP similar genes for BMP8A using alignment to 3 protein entries:     BMP8A_HUMAN (see all proteins):
    BMP8B    BMP7    NODAL    BMP6    BMP5    BMP4
    TGFB1    DKFZp686A06204    BMP2    GDF5    BMPY

    Find genes that share paralogs with BMP8A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BMP8A (see all 515)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10683041,2
    C,H--39955363(-) CCTCTC/GTGCAC 1 -- us2k16Minor allele frequency- G:0.00NS EA NA 422
    rs740693281,2
    C,F--39955463(+) TTTCTC/ACTCTG 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1499170151,2
    --39955554(+) CAGGGC/TCCTGA 1 -- us2k10--------
    rs1869032631,2
    --39955620(+) ACTTTA/CAACGG 1 -- us2k10--------
    rs120444361,2
    C--39955678(+) TCCGCA/GGGGTA 1 -- us2k13Minor allele frequency- G:0.27NA EA 124
    rs1906117141,2
    --39955690(+) CCCCGG/TCTTCT 1 -- us2k10--------
    rs7109191,2
    C,F,H--39955714(-) GAGCAG/CATGTG 1 -- us2k110Minor allele frequency- C:0.10EA NA NS WA 564
    rs29326401,2
    C,F,H--39955901(-) CATTTA/G/TGAAGT 1 -- us2k17NS NA WA CSA 207
    rs113517731,2
    C--39955910(+) TGTGAT/-TTTTG 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs7967081,2
    C--39955916(-) TGCCCT/CCAAAA 1 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for BMP8A (39957318 - 39995541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for BMP8A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2268423CNV Deletion18987734
    esv1368683CNV Insertion17803354
    nsv508160CNV Loss20534489
    nsv870462CNV Loss21882294
    nsv871499CNV Loss21882294
    nsv829649CNV Loss17160897
    nsv870829CNV Gain21882294
    nsv7177OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BMP8A
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP8A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with BMP8A           About GenesLikeMe

    Genetic Association Database (GAD): BMP8A
    Human Genome Epidemiology (HuGE) Navigator: BMP8A (2 documents)

    Export disorders for BMP8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BMP8A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with BMP8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. (PubMed id 22579288)2 Whittle A.J.... Vidal-Puig A. (Cell 2012)
    4. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    6. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. (PubMed id )2 
    10. Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: preliminary study. (PubMed id 18959789)9 Zekri A.R....Khaled H.M. (BMC Res Notes 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 353500 HGNC: 21650 AceView: BMP8A Ensembl:ENSG00000183682 euGenes: HUgn353500
    ECgene: BMP8A Kegg: 353500 H-InvDB: BMP8A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BMP8A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_8A

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BMP8A gene:
    Search GeneIP for patents involving BMP8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for BMP8A (BMP-8)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BMP8A   OriGene RNAi products in human, mouse, rat for BMP8A  
     OriGene qPCR primer pairs and template standards for BMP8A   OriGene Protein Over-expression Lysate for BMP8A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for BMP8A  
     OriGene qSTAR qPCR primer pairs in human, mouse for BMP8A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for BMP8A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BMP8A   OriGene Custom Protein Services for BMP8A  

     
     
     Block miRNA regulation of human, mouse, rat BMP8A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BMP8A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMP8A Predesigned siRNA for gene silencing in human, mouse, rat BMP8A
     QuantiFast Probe-based Assays in human, mouse, rat BMP8A QuantiTect SYBR Green Assays in human, mouse, rat BMP8A
     Custom PCR Arrays for BMP8A Search Chromatin IP Primers for BMP8A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BMP8A  Search GeneGlobe Interaction Network for BMP8A
     Regulatory tfbs in BMP8A promoter
     GenScript Custom Purified and Recombinant Proteins Services for BMP8A GenScript cDNA clones with any tag delivered in your preferred vector for BMP8A
     GenScript Custom Assay Services for BMP8A GenScript Custom overexpressing Cell Line Services for BMP8A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BMP8A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for BMP8A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BMP8A antibodies
     BMP8A proteins
     BMP8A lysates
     Antibodies for BMP8A
     See all of Abcam's Antibodies, Kits and Proteins for BMP8A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for BMP8A
     Antibodies for BMP8A
     ELISAs for BMP8A
     CLIAs for BMP8A



     Browse ESI BIO Cell Lines and PureStem Progenitors for BMP8A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP8A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for BMP8A
     SwitchGear Promoter luciferase reporter plasmids for BMP8A
     Search ThermoFisher Antibodies for BMP8A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP8A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BMP8A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BMP8A
     LSBio Antibodies in human, mouse, rat for BMP8A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for BMP8A
      Search eBioscience for proteins for BMP8A
      Search eBioscience for elisas for BMP8A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BMP8A gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4