Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BMP7 Gene

protein-coding   GIFtS: 72
GCID: GC20M055743

Bone Morphogenetic Protein 7

  See BMP7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Bone Morphogenetic Protein 71 2
Osteogenic Protein 11 2 3
OP-12 3
BMP-73
OP13
Eptotermin Alfa3

External Ids:    HGNC: 10741   Entrez Gene: 6552   Ensembl: ENSG000001011447   OMIM: 1122675   UniProtKB: P180753   

Export aliases for BMP7 gene to outside databases

Previous GC identifers: GC20M055473 GC20M056382 GC20M056430 GC20M055178 GC20M052525


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for BMP7 Gene:
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone
growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally
identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an
extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed
role in early development and possible bone inductive activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for BMP7 Gene:
BMP7 (bone morphogenetic protein 7) is a protein-coding gene. Diseases associated with BMP7 include ureteral obstruction, and spondylolisthesis. GO annotations related to this gene include growth factor activity and cytokine activity. An important paralog of this gene is GDF5.

UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075
Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis

Gene Wiki entry for BMP7 (Bone morphogenetic protein 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the BMP7 gene promoter:
         CRE-BP1   AP-1   ATF-2   MyoD   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP7 promoter sequence
   Search Chromatin IP Primers for BMP7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.31   HGNC cytogenetic band: 20q13

BMP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP7 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M055743:  view genomic region     (about GC identifiers)

Start:
55,743,804 bp from pter      End:
55,841,707 bp from pter
Size:
97,904 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075 (See protein sequence)
Recommended Name: Bone morphogenetic protein 7 precursor  
Size: 431 amino acids; 49313 Da
Subunit: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 (By similarity)
Developmental stage: Expressed in the developing eye, brain and ear during embryogenesis
4 PDB 3D structures from and Proteopedia for BMP7:
1BMP (3D)        1LX5 (3D)        1LXI (3D)        1M4U (3D)    
Secondary accessions: Q9H512 Q9NTQ7

Explore the universe of human proteins at neXtProt for BMP7: NX_P18075

Explore proteomics data for BMP7 at MOPED

Post-translational modifications: 

  • Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting
    in secretion of different mature forms (PubMed:17977014)1
  • Glycosylation2 at Asn187, Asn302, Asn321, Asn372
  • Modification sites at PhosphoSitePlus

  • See BMP7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001710.1  
    ENSEMBL proteins: 
     ENSP00000379204   ENSP00000379205   ENSP00000398687   ENSP00000390814  
    Reactome Protein details: P18075

    BMP7 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant BMP7 Protein
    R&D Systems Recombinant & Natural Proteins for BMP7 (BMP-7)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for BMP7
    OriGene Custom MassSpec
    OriGene Custom Protein Services for BMP7
    GenScript Purified and Recombinant Proteins for BMP7
    Novus Biologicals BMP7 Proteins
    Novus Biologicals BMP7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for BMP7
    Cloud-Clone Corp. Proteins for BMP7

     
    Search eBioscience for Proteins for BMP7 

    BMP7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BMP7
    R&D Systems Antibodies for BMP7 (BMP-7)
    Cell Signaling Technology (CST) Antibodies for BMP7 
    OriGene Antibodies for BMP7
    OriGene Custom Antibody Services for BMP7
    Novus Biologicals BMP7 Antibodies
    Abcam antibodies for BMP7
    Cloud-Clone Corp. Antibodies for BMP7
    ThermoFisher Antibody for BMP7
    LSBio Antibodies in human, mouse, rat for BMP7

    BMP7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BMP7
    R&D Systems ELISAs for BMP7 (BMP-7)
    GenScript Custom Assay Services for BMP7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BMP7
    Cloud-Clone Corp. CLIAs for BMP7
    Search eBioscience for ELISAs for BMP7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    BMP: Bone morphogenetic proteins

    4 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P18075

    ProtoNet protein and cluster: P18075

    3 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075
    Similarity: Belongs to the TGF-beta family


    Find genes that share domains with BMP7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP7_HUMAN, P18075
    Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
    epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis

         Genatlas biochemistry entry for BMP7:
    bone morphogenetic protein 7 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily)

         Summary: 
    During embryonic development, BMP7 as signaling molecule is secreted from the following cells:
                
    Kidney: Ureteric Bud Cells (Ureteric Bud)
    Brain: Meningeal Cells (Anterior Meninges)

    It affects the following cells:
          selected tissues (see all 6)      fully expand
    Adipose: Lumbar Committed Brown Preadipocytes (Cervical Brown Adipose Depot), Thoracic Brown Adipocyte Cells (Cervical Brown Adipose Depot)      fully expand to see all 8 cells
    Eye: Preplacodal Lens Ectoderm Cells (Lens Placode), Lens Placode Cells (Ocular Surface Ectoderm)      fully expand to see all 2 cells

    BMP7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 5)      fully expand
    Kidney: Intermediate mesoderm derivatives, Renal proximal tubularlike cells      fully expand to see all 3 cells
    Cartilage: Hypertrophic chondrocytes like cells, TGFbeta3+BMP7-induced chondrocytes      fully expand to see all 2 cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515contributes to protein binding IPI9872992
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with BMP7           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BMP7:
     Decreased homologous recombina  Decreased viability of wild-ty 

         Selected MGI mutant phenotypes (inferred from 10 alleles(MGI details for Bmp7) (see all 19):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  immune system  integument  limbs/digits/tail 
     mortality/aging  nervous system  normal  pigmentation  renal/urinary system 

    Find genes that share phenotypes with BMP7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BMP7: Bmp7tm1.2Dgra Bmp7tm1Kry Bmp7tm1Rob

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BMP7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BMP7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BMP7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BMP7

    miRNA
    Products:
        
    miRTarBase miRNAs that target BMP7:
    hsa-let-7b-5p (MIRT052250), hsa-mir-1 (MIRT023527), hsa-mir-342-3p (MIRT005882), hsa-mir-34a-5p (MIRT007204), hsa-mir-22-3p (MIRT002000)

    Block miRNA regulation of human, mouse, rat BMP7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMP7 (see all 33):
    hsa-miR-3678-3p hsa-miR-19b-2* hsa-miR-25 hsa-miR-30d hsa-miR-138-2* hsa-miR-570 hsa-miR-1184 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidBMP7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BMP7
    Predesigned siRNA for gene silencing in human, mouse, rat BMP7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BMP7

    Clone
    Products:
         
    OriGene clones in human, mouse for BMP7 (see all 6)
    OriGene ORF clones in mouse, rat for BMP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP7 (NM_001719)
    Sino Biological Human cDNA Clone for BMP7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BMP7
    Browse ESI BIO Cell Lines and PureStem Progenitors for BMP7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BMP7_HUMAN, P18075: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    golgi apparatus2
    mitochondrion2
    nucleus2
    plasma membrane2
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA17977014
    GO:0031012extracellular matrix IEA--
    GO:0031988membrane-bounded vesicle IEA--

    Find genes that share ontologies with BMP7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for BMP7 About   (see all 28)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58


    Find genes that share SuperPaths with BMP7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BMP7 (see all 73)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for BMP7
        Wnt / Hedgehog / Notch

    4 BioSystems Pathways for BMP7
        Neural Crest Differentiation
    Endochondral Ossification
    BMP receptor signaling
    ALK2 signaling events

    1 Sino Biological Pathway for BMP7
        TGF-beta Signaling Pathway

    1 Reactome Pathway for BMP7
        Molecules associated with elastic fibres


    3 Kegg Pathways  (Kegg details for BMP7):
        Cytokine-cytokine receptor interaction
    TGF-beta signaling pathway
    Hippo signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMP7 (see all 12): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BMP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BMP7 (P180752, 3 ENSP000003792044) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHRDL2Q6WN343, ENSP000002636714I2D: score=3 STRING: ENSP00000263671
    ACVR1Q047713, ENSP000002636404I2D: score=2 STRING: ENSP00000263640
    ACVR2BQ137053, ENSP000003403614I2D: score=2 STRING: ENSP00000340361
    GDF7Q7Z4P53, ENSP000002722244I2D: score=2 STRING: ENSP00000272224
    BMP4P126443, ENSP000002454514I2D: score=1 STRING: ENSP00000245451
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 77):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS2357959
    GO:0001503ossification IEA--
    GO:0001654eye development ----
    GO:0001656metanephros development IEP18437684
    GO:0001657ureteric bud development ISS--

    Find genes that share ontologies with BMP7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BMP7

    UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075
    Pharmaceutical: Available under the name Osigraft (Stryker). Its use is indicated in the treatment of tibial
    non-union of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where
    autograft has failed or is unfeasible

    1 HMDB Compound for BMP7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for BMP7 gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ursinus 76.2 12 16364199 (2), 19897401 (1), 8919034 (1), 17005018 (1) (see all 8)
    safran 65.8 3 8276880 (1), 8227084 (1)
    alginate 61.3 26 19475466 (5), 12919882 (2), 16320338 (2), 18686480 (1) (see all 11)
    safranin o 53.6 5 15693015 (2), 17205567 (1)
    pirfenidone 49.2 2 15726215 (1), 19935366 (1)
    hydroxyapatite 44.9 38 19063689 (4), 16963359 (3), 18366207 (2), 15003788 (2) (see all 12)
    tgf beta1 41.1 37 18040638 (7), 19950276 (4), 19741012 (4), 9326446 (3) (see all 6)
    carboxymethylcellulose 34.7 6 16799005 (2), 16035032 (2), 18303455 (1), 17048258 (1)
    titanium 29 6 19250243 (2), 15337402 (1), 19250245 (1)
    threonine 25.6 2 7791754 (1), 15450082 (1)



    Find genes that share compounds with BMP7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BMP7 gene: 
    NM_001719.2  

    Unigene Cluster for BMP7:

    Bone morphogenetic protein 7
    Hs.473163  [show with all ESTs]
    Unigene Representative Sequence: NM_001719
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395863(uc010gip.1) ENST00000395864 ENST00000476877 ENST00000460817
    ENST00000450594(uc002xyc.3) ENST00000433911 ENST00000463939 ENST00000524700
    ENST00000530870
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BMP7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMP7 (see all 33):
    hsa-miR-3678-3p hsa-miR-19b-2* hsa-miR-25 hsa-miR-30d hsa-miR-138-2* hsa-miR-570 hsa-miR-1184 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidBMP7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BMP7
    Predesigned siRNA for gene silencing in human, mouse, rat BMP7
    Clone
    Products:
         
    OriGene clones in human, mouse for BMP7 (see all 6)
    OriGene ORF clones in mouse, rat for BMP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP7 (NM_001719)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BMP7
    OriGene qSTAR qPCR primer pairs in human, mouse for BMP7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BMP7
      QuantiTect SYBR Green Assays in human, mouse, rat BMP7
      QuantiFast Probe-based Assays in human, mouse, rat BMP7

    Additional mRNA sequence: 

    AK094784.1 AK291186.1 AK312419.1 BC008584.1 EU679366.1 M60316.1 X51801.1 

    7 DOTS entries:

    DT.112582  DT.95155223  DT.100736594  DT.95239042  DT.97823505  DT.95073333  DT.40113485 

    Selected AceView cDNA sequences (see all 143):

    BE740547 BC008584 BG057007 BU535475 CR610754 BM683430 BG187538 BQ880022 
    BM694193 M60316 BX332927 BM927517 BC004248 BM694309 BU730428 BU149950 
    AW009846 CA396200 BM704733 BU956160 BU151160 AL538341 AL559873 AW665931 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BMP7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b
    SP1:                    -     -           -     -     -                                   -                 -               
    SP2:                    -     -           -     -     -                                   -                                 
    SP3:                    -     -                 -     -                                                                     
    SP4:                                                  -                                   -                                 
    SP5:                          -           -     -     -                                                                     


    ECgene alternative splicing isoforms for BMP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BMP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGGACTCG
    BMP7 Expression
    About this image


    BMP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 25) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 15 entries
             Prechondrocytes Autopod Epiphyseal End
     
     Tooth (Integumentary System)    fully expand to see all 12 entries
             Odontoblasts Dentin
             Dentin
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Meningeal Cells Anterior Meninges
             Cerebellum
             Midbrain dopaminergic-like neurons
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             Prechondrocytes Autopod Epiphyseal End
     
     Kidney (Urinary System)    fully expand to see all 6 entries
             Podocytes Podocyte Layer
             mK4
    BMP7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BMP7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473163

    UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075
    Tissue specificity: Expressed in the kidney and bladder. Lower levels seen in the brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMP7 (see all 12): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BMP7
    OriGene qSTAR qPCR primer pairs in human, mouse for BMP7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BMP7
    QuantiTect SYBR Green Assays in human, mouse, rat BMP7
    QuantiFast Probe-based Assays in human, mouse, rat BMP7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for BMP7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp71 , 5 bone morphogenetic protein 71, 5 90.31(n)1
    96.98(a)1
      2 (95.54 cM)5
    121621  NM_007557.31  NP_031583.21 
     1728680125 
    chicken
    (Gallus gallus)
    Aves BMP71 bone morphogenetic protein 7 81.72(n)
    89.81(a)
      395494  XM_417496.4  XP_417496.4 
    lizard
    (Anolis carolinensis)
    Reptilia BMP76
    bone morphogenetic protein 7
    82(a)
    1 ↔ 1
    GL343217.1(1297771-1393200)
    African clawed frog
    (Xenopus laevis)
    Amphibia bmp7-prov2 bone morphogenetic protein 7 76.86(n)    BC055959.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bmp7b1 bone morphogenetic protein 7b 77.45(n)
    82.48(a)
      557567  NM_001077146.1  NP_001070614.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gbb1 , 3 TGFbeta receptor signaling pathway
    transforming more3
    glass bottom boat1
    35(a)
    (best of 2)3
    54.7(n)1
    40.1(a)1
      377781  NM_057992.21  NP_477340.11 


    ENSEMBL Gene Tree for BMP7 (if available)
    TreeFam Gene Tree for BMP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BMP7 gene
    GDF52  BMP52  GDF32  BMP8B2  GDF62  BMP42  GDF72  GDF22  
    BMP22  BMP102  GDF12  BMP8A2  BMP62  
    10 SIMAP similar genes for BMP7 using alignment to 7 protein entries:     BMP7_HUMAN (see all proteins):
    BMP5    BMP8A    BMP6    TGFB1    BMP8B    TGFB3
    BMPY    BMP2    BMP4    INHA

    Find genes that share paralogs with BMP7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BMP7 (see all 2274)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446844871,2
    C--55712717(+) AGTCGC/TGCTCC 1 -- ds50010--------
    rs1812358601,2
    --55712743(+) CATTTA/GCACTG 1 -- ds50010--------
    rs110865961,2
    C,F,A,H--55712819(+) TCTCTG/ATGGTG 1 -- ds500120Minor allele frequency- A:0.37NS EA NA WA 2346
    rs1386257071,2
    C--55712858(+) TTCAAA/CTATGT 1 -- ds50010--------
    rs1411455501,2
    C--55712879(+) CACAGC/TTAATT 1 -- ds50010--------
    rs110865971,2
    C,F,A,H--55712999(+) TGCCCG/AGAGCC 1 -- ds500113Minor allele frequency- A:0.46NS EA NA CSA WA 768
    rs60645061,2
    C,F,A,H--55713046(+) TCCCCG/CCAAGG 1 -- ds500113Minor allele frequency- C:0.49NS EA NA CSA WA 792
    rs1142610371,2
    F--55713128(+) GTGTCC/TAAGAA 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs110865981,2
    C,F,A,H--55713172(+) CAGGCC/TAAAGA 1 -- ds500114Minor allele frequency- T:0.49NS EA NA CSA WA 788
    rs1507274791,2
    --55713263(+) TGCTCA/GACGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BMP7 (55743804 - 55841707 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for BMP7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673209CNV Deletion23128226
    esv2668178CNV Deletion23128226
    esv1010828CNV Deletion20482838
    esv2722599CNV Deletion23290073
    esv1062572CNV Deletion17803354
    esv2722600CNV Deletion23290073
    esv2722598CNV Deletion23290073
    nsv523091CNV Loss19592680
    nsv912957CNV Loss21882294
    esv24660CNV Loss19812545

    Human Gene Mutation Database (HGMD): BMP7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BMP7
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 112267    OMIM disorders: --

    8 diseases for BMP7:    
    About MalaCards
    ureteral obstruction    spondylolisthesis    spondylolysis    spinal stenosis
    renal fibrosis    ureteral disease    cerebral hypoxia    osteochondritis dissecans

    5 diseases from the University of Copenhagen DISEASES database for BMP7:
    Spondylolisthesis     Kidney disease     Spinal stenosis     Osteoarthritis
    Ureteral disease

    Find genes that share disorders with BMP7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BMP7 gene (see all 68)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal fibrosis 72.6 14 18266088 (3), 19557718 (2), 15794307 (1), 17376778 (1) (see all 9)
    degenerative spondylolisthesis 65.8 10 16371892 (2), 15672240 (1), 19092614 (1), 15534410 (1) (see all 7)
    furcation defects 64.4 4 9526911 (2), 19897401 (1)
    spondylolisthesis 43 3 15672240 (1), 15534410 (1), 12908103 (1)
    arthrodesis 42.9 12 19092614 (3), 12205422 (2), 10101812 (1), 17588821 (1) (see all 9)
    renal disease 41.4 49 15199292 (5), 18508541 (3), 16686760 (2), 17456853 (2) (see all 21)
    spinal stenosis 39.9 10 15672240 (2), 12908103 (2), 10232555 (1), 17669279 (1) (see all 6)
    osteosarcoma 39.8 24 9322936 (3), 9069169 (2), 10716620 (2), 9565067 (2) (see all 10)
    pseudarthrosis 39.5 13 16601593 (3), 17977189 (2), 16365133 (1), 19579208 (1) (see all 6)
    ossification heterotopic 37.8 2 19043134 (1), 17482003 (1)

    Genetic Association Database (GAD): BMP7
    Human Genome Epidemiology (HuGE) Navigator: BMP7 (17 documents)

    Export disorders for BMP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BMP7 gene, integrated from 10 sources (see all 642):
    (articles sorted by number of sources associating them with BMP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and characterization of a human BMP-7 variant with improved biochemical properties. (PubMed id 17977014)1, 2, 9 Swencki-Underwood B.... Amegadzie B. (Protein Expr. Purif. 2008)
    2. Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily. (PubMed id 8570652)1, 2, 9 Griffith D.L.... Carlson W.D. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    3. A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. (PubMed id 1427904)1, 3, 9 Hahn G.V....Kaplan F.S. (Genomics 1992)
    4. Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study. (PubMed id 19453255)1, 4, 9 Freedman B.I....Carr J.J. (J. Bone Miner. Res. 2009)
    5. OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. (PubMed id 2357959)1, 2, 9 Oezkaynak E.... Oppermann H. (EMBO J. 1990)
    6. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. (PubMed id 2263636)1, 2, 9 Celeste A.J.... Wozney J.M. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    7. Bone morphogenetic protein 7 (BMP7) mutations are associated with variable ocular, brain, ear, palate, and skeletal anomalies. (PubMed id 20506283)1, 2 Wyatt A.W.... Ragge N.K. (Hum. Mutat. 2010)
    8. A genomewide association study of citalopram response in major depressive disorder. (PubMed id 19846067)1, 4 Garriock H.A....Hamilton S.P. (Biol. Psychiatry 2010)
    9. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    10. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 655 HGNC: 1074 AceView: BMP7 Ensembl:ENSG00000101144 euGenes: HUgn655
    ECgene: BMP7 Kegg: 655 H-InvDB: BMP7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BMP7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP7 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_7

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BMP7 gene:
    Search GeneIP for patents involving BMP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant BMP7 Protein
     EMD Millipore Mono- and Polyclonal Antibodies for the study of BMP7
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for BMP7 (BMP-7)   Browse Cell Culture Products  
     ELISAs for BMP7 (BMP-7)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for BMP7 (BMP-7)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BMP7   OriGene RNAi products in human, mouse, rat for BMP7  
     OriGene qPCR primer pairs and template standards for BMP7   OriGene Protein Over-expression Lysate for BMP7  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for BMP7  
     OriGene qSTAR qPCR primer pairs in human, mouse for BMP7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for BMP7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BMP7   OriGene Custom Protein Services for BMP7  

     
     
     Block miRNA regulation of human, mouse, rat BMP7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BMP7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMP7 Predesigned siRNA for gene silencing in human, mouse, rat BMP7
     QuantiFast Probe-based Assays in human, mouse, rat BMP7 QuantiTect SYBR Green Assays in human, mouse, rat BMP7
     PCR Arrays including human, mouse, rat BMP7 Search Chromatin IP Primers for BMP7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BMP7  GeneGlobe Interaction Network for BMP7
     Regulatory tfbs in BMP7 promoter
     GenScript Purified and Recombinant Proteins for BMP7 GenScript cDNA clones with any tag delivered in your preferred vector for BMP7
     GenScript Custom Assay Services for BMP7 GenScript Custom overexpressing Cell Line Services for BMP7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for BMP7 

     Search Tocris compounds for BMP7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for BMP7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BMP7 antibodies
     BMP7 proteins
     BMP7 lysates
     Antibodies for BMP7
     See all of Abcam's Antibodies, Kits and Proteins for BMP7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for BMP7
     Proteins for BMP7
     Antibodies for BMP7
     ELISAs for BMP7
     CLIAs for BMP7



     Browse ESI BIO Cell Lines and PureStem Progenitors for BMP7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP7
     SwitchGear 3'UTR luciferase reporter plasmids for BMP7
     SwitchGear Promoter luciferase reporter plasmids for BMP7
     ThermoFisher Antibody for BMP7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BMP7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BMP7
     LSBio Antibodies in human, mouse, rat for BMP7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for BMP7
      Search eBioscience for proteins for BMP7
      Search eBioscience for elisas for BMP7
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BMP7 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4