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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BMP7 Gene

protein-coding   GIFtS: 71
GCID: GC20M055743

bone morphogenetic protein 7
 Explore 91 diseases affiliated with
BMP7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BMP7    

Aliases
for BMP7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Bone Morphogenetic Protein 71 2
OP-11 2 3
Osteogenic Protein 12 3
BMP-73
OP13
Eptotermin Alfa3

External Ids:    HGNC: 10741   Entrez Gene: 6552   Ensembl: ENSG000001011447   OMIM: 1122675   UniProtKB: P180753   

Export aliases for BMP7 gene to outside databases

Previous GC identifers: GC20M055473 GC20M056382 GC20M056430 GC20M055178 GC20M052525


Summaries
for BMP7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BMP7:
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone
growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified
by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.
Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development
and possible bone inductive activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075
Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis

Gene Wiki entry for BMP7 (Bone morphogenetic protein 7)


Genomic Views
for BMP7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMP7 gene promoter:
         CRE-BP1   AP-1   ATF-2   MyoD   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BMP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for BMP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.31   HGNC cytogenetic band: 20q13

BMP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP7 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M055743:  view genomic region     (about GC identifiers)

Start:
 55,743,804 bp from pter      End:
 55,841,707 bp from pter
Size:
 97,904 bases      Orientation:
 minus strand

Proteins
for BMP7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075 (See protein sequence)
Recommended Name: Bone morphogenetic protein 7 precursor  
Size: 431 amino acids; 49313 Da
Subunit: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 (By similarity)
Subcellular location: Secreted
Developmental stage: Expressed in the developing eye, brain and ear during embryogenesis
4 PDB 3D structures from and Proteopedia for BMP7:
1BMP (3D)        1LX5 (3D)        1LXI (3D)        1M4U (3D)    
Secondary accessions: Q9H512 Q9NTQ7

Explore the universe of human proteins at neXtProt for BMP7: NX_P18075

Post-translational modifications:

  • Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in
    • secretion of different mature forms (PubMed:17977014)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P18075

    • BMP7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001710.1  
    ENSEMBL proteins: 
     ENSP00000379204   ENSP00000379205   ENSP00000398687   ENSP00000390814  
    Reactome Protein details: P18075
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant BMP7 Protein
    R&D Systems Recombinant & Natural Proteins for BMP7 (BMP-7)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: BMP7
    OriGene Custom Protein Services for BMP7 
    GenScript Purified and Recombinant Proteins for BMP7
    Novus Biologicals BMP7 Proteins
    Novus Biologicals BMP7 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for BMP7
    Uscn Proteins for BMP7

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA17977014


    BMP7 for ontologies           About GeneDecksing



    BMP7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BMP7
    R&D Systems Antibodies for BMP7 (BMP-7)
    Cell Signaling Technology (CST) Antibodies for BMP7 
    OriGene Antibodies: BMP7
    OriGene Custom Antibody Services for BMP7 
    GenScript Superior Antibodies for BMP7
    Novus Biologicals BMP7 Antibodies
    Abcam antibodies for BMP7 
    Uscn Antibodies for BMP7
    ThermoFisher Antibody for BMP7

    Assay Products for BMP7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for BMP7 (BMP-7)
    GenScript Custom Assay Services for BMP7
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BMP7

    Protein Domains /
    Families
    for BMP7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BMP7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P18075

    ProtoNet protein and cluster: P18075

    3 Blocks protein families:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075
    Similarity: Belongs to the TGF-beta family


    Function
    for BMP7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075
    Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of
    epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis

         Genatlas biochemistry entry for BMP7:
    bone morphogenetic protein 7 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily)

         Summary:  
    During embryonic development, BMP7 as signaling molecule is secreted from the following cells: Meningeal Cells in Anterior Meninges, Ureteric Bud Cells in Ureteric Bud

    It affects the following cells: Cervical Brown Adipocyte Cells in Cervical Brown Adipose Depot, Cervical Committed Brown Preadipocytes in Cervical Brown Adipose Depot (see all 13).

    BMP7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Intermediate mesoderm derivatives, Intermediate mesoderm-like cells (see all 7).

    miRNA
    Products:            		miRTarBase miRNAs that target BMP7:
    hsa-mir-342-3p (MIRT005882), hsa-mir-22 (MIRT002000)

    OriGene 3'-UTR Clone: BMP7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMP7
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP7 (see all 33):
    hsa-miR-3678-3p hsa-miR-19b-2* hsa-miR-25 hsa-miR-30d hsa-miR-138-2* hsa-miR-570 hsa-miR-1184 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: BMP7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMP7 (see all 4)
    OriGene shRNA RFP: BMP7
    OriGene siRNA: BMP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BMP7

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMP7 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMP7
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BMP7 (NM_001719)
    Sino Biological Human cDNA Clone for BMP7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP7 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for BMP7
    Search LifeMap BioReagents cell lines for BMP7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP7

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515contributes to protein binding IPI9872992
    GO:0008083growth factor activity IEA--


    BMP7 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for BMP7:
     Decreased homologous recombina  Decreased viability of wild-ty 

    Animal Models:
         Mouse knock-outs for BMP7: Bmp7tm1.2Dgra Bmp7tm1Kry Bmp7tm1Rob
         15/19 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for Bmp7) (see all 19):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  immune system  integument  limbs/digits/tail 
     mortality/aging  nervous system  normal  pigmentation  renal/urinary system 

    BMP7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BMP7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/27 super-pathways (see all 27) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2PEDF Induced Signaling
    8/12 pathways (see all 12)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    3GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/73 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BMP7 (see all 73)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for BMP7
        Wnt / Hedgehog / Notch

    4 BioSystems Pathways for BMP7 
        Neural Crest Differentiation
    Endochondral Ossification
    ALK2 signaling events
    BMP receptor signaling

    3        Reactome Pathways for BMP7
        Molecules associated with elastic fibres
    Extracellular matrix organization
    Elastic fibre formation


    3         Kegg Pathways  (Kegg details for BMP7):
        Cytokine-cytokine receptor interaction
    Hedgehog signaling pathway
    TGF-beta signaling pathway


    BMP7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BMP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for BMP7 (P180752, 3 ENSP000003792044) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR1AP368943, ENSP000002247644I2D: score=3 STRING: ENSP00000224764
    CHRDL2Q6WN343, ENSP000002636714I2D: score=3 STRING: ENSP00000263671
    ACVR1Q047713, ENSP000002636404I2D: score=2 STRING: ENSP00000263640
    ACVR2BQ137053, ENSP000003403614I2D: score=2 STRING: ENSP00000340361
    GDF7Q7Z4P53, ENSP000002722244I2D: score=2 STRING: ENSP00000272224
    About this table

    Gene Ontology (GO): 5/73 biological process terms (GO ID links to tree view) (see all 73):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS2357959
    GO:0001503ossification IEA--
    GO:0001654eye development ----
    GO:0001656metanephros development IEP18437684
    GO:0001657ureteric bud development ISS--


    BMP7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BMP7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BMP7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BMP7
    UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075
    Pharmaceutical: Available under the name Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union
    of at least 9 months duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed
    or is unfeasible


    1 HMDB Compound for BMP7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    10/41 Novoseek chemical compound relationships for BMP7 gene (see all 41)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ursinus 76.2 12 16364199 (2), 19897401 (1), 8919034 (1), 17005018 (1) (see all 8)
    safran 65.8 3 8276880 (1), 8227084 (1)
    alginate 61.3 26 19475466 (5), 12919882 (2), 16320338 (2), 18686480 (1) (see all 11)
    safranin o 53.6 5 15693015 (2), 17205567 (1)
    pirfenidone 49.2 2 15726215 (1), 19935366 (1)
    hydroxyapatite 44.9 38 19063689 (4), 16963359 (3), 18366207 (2), 15003788 (2) (see all 12)
    tgf beta1 41.1 37 18040638 (7), 19950276 (4), 19741012 (4), 9326446 (3) (see all 6)
    carboxymethylcellulose 34.7 6 16799005 (2), 16035032 (2), 18303455 (1), 17048258 (1)
    titanium 29 6 19250243 (2), 15337402 (1), 19250245 (1)
    threonine 25.6 2 7791754 (1), 15450082 (1)

    Search CenterWatch for drugs/clinical trials and news about BMP7 

    Transcripts
    for BMP7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BMP7 gene: 
    NM_001719.2  

    Unigene Cluster for BMP7:

    Bone morphogenetic protein 7
    Hs.473163  [show with all ESTs]
    Unigene Representative Sequence: NM_001719
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395863(uc010gip.1) ENST00000395864 ENST00000476877 ENST00000460817
    ENST00000450594(uc002xyc.3) ENST00000433911 ENST00000463939 ENST00000524700
    ENST00000530870

    miRNA
    Products:             		 OriGene 3'-UTR Clone: BMP7
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMP7
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP7 (see all 33):
    hsa-miR-3678-3p hsa-miR-19b-2* hsa-miR-25 hsa-miR-30d hsa-miR-138-2* hsa-miR-570 hsa-miR-1184 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: BMP7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMP7 (see all 4)
    OriGene shRNA RFP: BMP7
    OriGene siRNA: BMP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP7
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMP7 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMP7
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BMP7 (NM_001719)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP7 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BMP7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BMP7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP7

    Additional cDNA sequence: 

    AK094784.1 AK291186.1 AK312419.1 BC008584.1 EU679366.1 M60316.1 X51801.1 

    7 DOTS entries:

    DT.112582  DT.95155223  DT.100736594  DT.95239042  DT.97823505  DT.95073333  DT.40113485 

    24/143 AceView cDNA sequences (see all 143):

    BU535475 BM927517 CA396200 BC008584 AL538341 BU730428 BU956160 BE740547 
    BU151160 BU149950 BC004248 M60316 BX332927 BM704733 BG057007 CR610754 
    AW009846 BG187538 BM694193 BQ880022 BM694309 BM683430 AI190246 AI066433 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BMP7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b
    SP1:                    -     -           -     -     -                                   -                 -               
    SP2:                    -     -           -     -     -                                   -                                 
    SP3:                    -     -                 -     -                                                                     
    SP4:                                                  -                                   -                                 
    SP5:                          -           -     -     -                                                                     


    ECgene alternative splicing isoforms for BMP7

    Expression
    for BMP7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BMP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACGGACTCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BMP7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/40 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 40) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainAnterior MeningesMeningeal CellsMeninges
    BoneAutopod Epiphyseal EndChondrocytesBone, Cartilage
    BoneAutopod Epiphyseal EndPrechondrocytesBone, Cartilage
    BoneAutopod PerichondriumEndochondral PreosteoblastsBone
    BoneCervical VertebraeChondrocytesBone, Cartilage
    BoneCervical VertebraeEndochondral PreosteoblastsBone
    BoneFacial SuturesFacial Presumptive Suture CellsBone
    BoneLumbar VertebraeChondrocytesBone, Cartilage
    BoneLumbar VertebraeEndochondral PreosteoblastsBone
    BoneRostral SuturesRostral Presumptive Suture CellsBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    mK4 (Cell line)Kidney
    mK3 (Cell line)Kidney
    Midbrain dopaminergic-like neurons (Generation of midbra...)

    See BMP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BMP7

    SOURCE GeneReport for Unigene cluster: Hs.473163

    UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075
    Tissue specificity: Expressed in the kidney and bladder. Lower levels seen in the brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including BMP7 (see all 12): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Fibrosis in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for BMP7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for BMP7 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BMP71 bone morphogenetic protein 7 82.16(n)
    90.31(a)    		   395494  XM_417496.3  XP_417496.3 
    African clawed frog
    (Xenopus laevis)    		 Amphibia bmp7-prov2 bone morphogenetic protein 7 76.86(n)    BC055959.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii bmp7b1 bone morphogenetic protein 7b 77.53(n)
    82.48(a)    		   557567  NM_001077146.1  NP_001070614.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta gbb3 TGFbeta receptor signaling pathway
    transforming more    		 35(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea dbl-13 TGF-beta-like growth factor 32(a)   V(6760886-6762540)   --


    ENSEMBL Gene Tree for BMP7 (if available)
    TreeFam Gene Tree for BMP7 (if available) 

    Paralogs
    for BMP7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BMP7 gene
    GDF52  GDF32  BMP52  GDF62  BMP8B2  BMP42  GDF72  GDF22  
    BMP22  BMP102  BMP32  GDF102  GDF12  BMP8A2  BMP62  
    9 SIMAP similar genes for BMP7 using alignment to 7 protein entries:     BMP7_HUMAN (see all proteins):
    BMP8A    BMP5    BMP6    TGFB1    BMP8B    TGFB3
    BMPY    INHA    BMP2

    BMP7 for paralogs           About GeneDecksing



    Genomic Variants
    for BMP7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1908 NCBI SNPs in BMP7 are shown (see all 1908)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1446844871,2
    		--55743348(+) AGTCGC/TGCTCC 1 -- ds50010--------
    rs1812358601,2
    		--55743374(+) CATTTA/GCACTG 1 -- ds50010--------
    rs110865961,2
    		C,F,A,H,--55743450(+) TCTCTG/ATGGTG 1 -- ds500120Minor allele frequency- A:0.37NS EA NA WA 2346
    rs1386257071,2
    		--55743489(+) TTCAAA/CTATGT 1 -- ds50010--------
    rs1411455501,2
    		--55743510(+) CACAGC/TTAATT 1 -- ds50010--------
    rs110865971,2
    		C,F,A,H,--55743630(+) TGCCCG/AGAGCC 1 -- ds500113Minor allele frequency- A:0.46NS EA NA CSA WA 768
    rs60645061,2
    		C,F,A,H,--55743677(+) TCCCCG/CCAAGG 1 -- ds500113Minor allele frequency- C:0.49NS EA NA CSA WA 792
    rs1142610371,2
    		F,--55743759(+) GTGTCC/TAAGAA 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs110865981,2
    		C,F,A,H,--55743803(+) CAGGCC/TAAAGA 1 -- ds500114Minor allele frequency- T:0.49NS EA NA CSA WA 788
    rs1507274791,2
    		--55743894(+) TGCTCA/GACGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BMP7 (55743804 - 55841707 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for BMP7
         2 Indels: 79246 73542
    Human Gene Mutation Database (HGMD): BMP7

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BMP7
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP7

    Disorders / Diseases
    for BMP7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BMP7 for disorders           About GeneDecksing

    OMIM gene information: 112267    OMIM disorders: --

    20/91 diseases for BMP7 (see all 91):    About MalaCards
    acid-labile subunit    spinal stenosis    open-angle glaucoma    primary open angle glaucoma
    osteochondritis dissecans    cleft lip/palate    spondylolisthesis    ureteral obstruction
    renal osteodystrophy    spondylolysis    cleft lip    type 1 diabetes mellitus
    major depressive disorder    inflammatory bowel disease    corpus callosum    diabetes mellitus
    ankylosing spondylitis    glaucoma    oral squamous cell carcinoma    secondary hyperparathyroidism

    5 diseases from the University of Copenhagen DISEASES database for BMP7:
    Spondylolisthesis     Kidney disease     Spinal stenosis     Osteoarthritis
    Ureteral disease

    10/68 Novoseek disease relationships for BMP7 gene (see all 68)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal fibrosis 72.6 14 18266088 (3), 19557718 (2), 15794307 (1), 17376778 (1) (see all 9)
    degenerative spondylolisthesis 65.8 10 16371892 (2), 15672240 (1), 19092614 (1), 15534410 (1) (see all 7)
    furcation defects 64.4 4 9526911 (2), 19897401 (1)
    spondylolisthesis 43 3 15672240 (1), 15534410 (1), 12908103 (1)
    arthrodesis 42.9 12 19092614 (3), 12205422 (2), 10101812 (1), 17588821 (1) (see all 9)
    renal disease 41.4 49 15199292 (5), 18508541 (3), 16686760 (2), 17456853 (2) (see all 21)
    spinal stenosis 39.9 10 15672240 (2), 12908103 (2), 10232555 (1), 17669279 (1) (see all 6)
    osteosarcoma 39.8 24 9322936 (3), 9069169 (2), 10716620 (2), 9565067 (2) (see all 10)
    pseudarthrosis 39.5 13 16601593 (3), 17977189 (2), 16365133 (1), 19579208 (1) (see all 6)
    ossification heterotopic 37.8 2 19043134 (1), 17482003 (1)

    Human Genome Epidemiology (HuGE) Navigator: BMP7 (17 documents)

    Export disorders for BMP7 gene to outside databases

    Publications
    for BMP7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BMP7 gene, integrated from 9 sources (see all 622):
    (articles sorted by number of sources associating them with BMP7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and characterization of a human BMP-7 variant with improved biochemical properties. (PubMed id 17977014)1, 2, 9 Swencki-Underwood B....Amegadzie B. (2008)
    2. Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily. (PubMed id 8570652)1, 2, 9 Griffith D.L.... Carlson W.D. (1996)
    3. A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. (PubMed id 1427904)1, 3, 9 Hahn G.V....Kaplan F.S. (1992)
    4. OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. (PubMed id 2357959)1, 2, 9 Oezkaynak E.... Oppermann H. (1990)
    5. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. (PubMed id 2263636)1, 2, 9 Celeste A.J.... Wozney J.M. (1990)
    6. Bone morphogenetic protein 7 (BMP7) mutations are ass ociated with variable ocular, brain, ear, palate, and skeletal anomalies. (PubMed id 20506283)1, 2 Wyatt A.W....Ragge N.K. (2010)
    7. USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. (PubMed id 15020244)1, 2 Yanagita M.... Sakurai T. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    10. Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage. (PubMed id 12925612)1, 9 Merrihew C....Chubinskaya S. (2003)

    External Searches for BMP7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BMP7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 655 HGNC: 1074 AceView: BMP7 Ensembl:ENSG00000101144 euGenes: HUgn655
    ECgene: BMP7 Kegg: 655 H-InvDB: BMP7

    Other Databases showing BMP7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BMP7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BMP7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP7 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_7

    Intellectual Property
    for BMP7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BMP7 gene:
    Search GeneIP for patents involving BMP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for BMP7 gene

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    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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