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BMP7 Gene

protein-coding GIFtS: 66

GC20M055178

bone morphogenetic protein 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BMP-7 ^³
OP-1 ^¹, ², ³
OP1 ^³
OTTHUMP00000031357 ^²

Descriptions
Eptotermin alfa ^³
Osteogenic protein 1 ^², ³
bone morphogenetic protein 7 ^²

External Ids
HGNC: 1074¹
Entrez Gene: 655²
UniProtKB: P18075³
Ensembl: ENSG00000101144⁷

Search outside databases for aliases for BMP7 gene

Previous GC identifers: GC20M055473 GC20M056382 GC20M056430

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BMP7:

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce

ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily.

BMPs were originally identified by an ability of demineralized bone extract to induce endochondral

osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the

BMP encoded by this gene has a proposed role in early development and possible bone inductive

activity. [provided by RefSeq]

UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075

Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for

the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BMP7 gene

Entrez Gene cytogenetic band: 20q13 Ensembl cytogenetic band: 20q13.31 HGNC cytogenetic band: 20q13

BMP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M055178: (about GC identifiers)

Start:	55,178,962 bp from pter
End:	55,275,092 bp from pter
Size:	96,131 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075 (See protein sequence)

Recommended Name: Bone morphogenetic protein 7 precursor

Size: 431 amino acids; 49313 Da

Subunit: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 (By similarity)

Subcellular location: Secreted

PDB structures from and Proteopedia :

1BMP (3D)

1LX5 (3D)

1LXI (3D)

1M4U (3D)

Secondary accessions: Q9H512 Q9NTQ7

Post-translational modifications:

Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct

sequencing resulting in secretion of different mature forms (PubMed:17977014)¹

REFSEQ proteins: NP_001710.1

ENSEMBL proteins:

ENSP00000379205 ENSP00000379204 ENSP00000360340

Human Recombinant Proteins

	Invitrogen human recombinant proteins for BMP7
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for BMP7
	R&D Systems Recombinant & Natural Proteins for BMP7 (BMP-7)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BMP7)
	Human Recombinant Proteins from Abnova (BMP7)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

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Antibodies for BMP7:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for BMP7
	R&D Systems Antibodies for BMP7 (BMP-7)
	Cell Signaling Technology (CST) Antibodies for BMP7
	Antibodies from Abcam (BMP7), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BMP7)
	Novus Biologicals Antibodies for BMP7

Assays for BMP7:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for BMP7 (BMP-7) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P18075

ProtoNet protein and cluster: P18075

3 Blocks protein families:

IPB001111 Transforming growth factor beta (TGFb)

IPB001839 Transforming growth factor beta (TGFb)

IPB002400 Growth factor cystine knot superfamily signature

UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075

Similarity: Belongs to the TGF-beta family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BMP7)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BMP7)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001719

Applied Biosystems Silencer® siRNAs for BMP7

Sigma-Aldrich siRNA and siRNA Panels for BMP7

Sigma-Aldrich shRNA for BMP7

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BMP7
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001719
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001719
untagged cDNA clone in CMV expression vector: NM_001719

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001719

UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075

Function: Induces cartilage and bone formation. May be the osteoinductive factor responsible for

the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis

Genatlas biochemistry entry for BMP7:

bone morphogenetic protein 7 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily)

15/16 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Bmp7) (see all 16 ):

	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	immune system	lethality-postnatal	lethality-prenatal/perinatal	limbs/digits/tail
nervous system	normal	renal/urinary system	reproductive system	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005515	protein binding	IPI	12478285 12667445
GO:0008083	growth factor activity	IEA	--
GO:0008201	heparin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for BMP7 (Your Favorite Gene powered by Ingenuity) (see all 9 )

Basal Cell Carcinoma Signaling
Axonal Guidance Signaling
BMP signaling pathway
Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
Molecular Mechanisms of Cancer

GeneDecks BMP7 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BMP7

5/95 Interacting proteins for BMP7 (P18075^{1, 2} ENSP00000360340³) via UniProtKB, MINT, and/or STRING (see all 95 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NOG	Q13253¹, ENSP00000328181³	EBI-1035195, EBI-1035205 STRING (score=.999)
Acvr2a Acvr2a (xeno)	P27038¹	EBI-1035195, EBI-1036102
ACVR2A	ENSP00000241416³	STRING (score=.999)
BMPR2	ENSP00000363708³	STRING (score=.999)
SOSTDC1	ENSP00000304930³	STRING (score=.999)

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5/27 Gene Ontology (GO) biological process terms (links to tree view) (see all 27 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	IEA	--
GO:0001707	mesoderm formation	IEA	--
GO:0001822	kidney development	IEA	--
GO:0001837	epithelial to mesenchymal transition	TAS	14679171
GO:0007411	axon guidance	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BMP7
UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075

Pharmaceutical: Available under the names Osigraft (Stryker). Its use is indicated in the treatment

of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature

patients, in cases where autograft has failed or is unfeasible

10/21 Novoseek chemical compound relationships for BMP7 gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
safran	67.63	3	8276880 (1), 8227084 (1)
hydroxyapatite	45.30	38	19063689 (4), 16963359 (3), 18366207 (2), 15003788 (2) (see all 12)
tgf beta1	34.28	20	18040638 (7), 9326446 (3), 19112509 (2), 18434375 (1)
titanium	27.21	1	15337402 (1)
threonine	25.98	2	7791754 (1), 15450082 (1)
calcium hydroxide	20.61	2	7575242 (1)
deoxyribonucleic acid	15.04	4	18575444 (1), 10340856 (1), 12205411 (1)
gold	5.82	2	14588284 (1), 10983596 (1)
tyrosine	5.51	2	7496035 (1), 8598449 (1)
lipid	1.25	2	17497692 (1), 8549671 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BMP7)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BMP7)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001719

Sigma-Aldrich siRNA and siRNA Panels for BMP7

Sigma-Aldrich shRNA for BMP7

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001719

REFSEQ mRNAs for BMP7 gene:

NM_001719.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001719

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001719
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001719
                                 untagged cDNA clone in CMV expression vector: NM_001719

Additional cDNA sequence:

AK094784.1 AK291186.1 AK312419.1 BC008584.1 CR610754.1 EU679366.1 M60316.1 X51801.1

7 DOTS entries:

DT.112582 DT.95155223 DT.100736594 DT.95239042 DT.97823505 DT.95073333 DT.40113485

24/143 AceView cDNA sequences (see all 143 ):

AL538341 BM927517 BC004248 BU730428 BG057007 CA396200 BE740547 BX332927

CR610754 BU151160 BU956160 BM694193 BQ880022 AW009846 BG187538 BU535475

BC008584 M60316 BM683430 BM694309 BU149950 BM704733 BU557947 AI359736

highest scoring ESTs for BMP7:

X51801 AI094860 AL528073 BC004248 BC008584 BE616633 BF338314 BG914310 BM458426 BM694309

Unigene Cluster for BMP7:

Bone morphogenetic protein 7

Hs.473163 [show with all ESTs]

Unigene Representative Sequence: NM_001719

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BMP7 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	·	11c	·	11d	^	12a	·	12b
SP1:							-		-				-		-		-												-						-
SP2:							-		-				-		-		-												-
SP3:							-		-						-		-
SP4:																	-												-
SP5:									-				-		-		-

About this scheme

ECgene alternative splicing isoforms for BMP7

3 Ensembl transcripts including schematic representations:

ENST00000395864 ENST00000395863 ENST00000371291

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BMP7 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BMP7

¹ / ² / ³

12 probe-sets matching BMP7 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
49267_at²^{, 3}	U95-B	1	1.00	1.00	0.39	1.16	AI332852	0.40	1.00	0.76	1
49273_g_at²^{, 3}	U95-B	1	1.00	1.00	0.98	0.91	AI332852	0.40	1.00	0.76	1
38515_at²^{, 3}	U95-A	1	1.00	1.00	0.86	0.67	X51801	1.00	1.00	1.00	1
64137_at²^{, 3}	U95-C	1	1.00	1.00	0.99	1.32	AI094860	0.80	1.00	0.91	1
209590_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
209591_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M60316	0.80	1.00	0.91	1
211260_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC004248	0.80	1.00	0.91	1
211259_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC004248	0.80	1.00	0.91	1
209590_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209591_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211260_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211259_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BMP7 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACGGACTCG

SOURCE GeneReport for Unigene cluster: Hs.473163
Expression variation in blood from EXPOLDB for BMP7
UniProtKB/Swiss-Prot: BMP7_HUMAN, P18075
Tissue specificity: Expressed in the kidneys and bladder. Lower levels seen in the brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BMP7 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BMP7¹	--	bone morphogenetic protein 7	92.5(n) 95.82(a)	477270 XM_862341.1 XP_867434.1
chimpanzee (Pan troglodytes)	BMP7¹	--	bone morphogenetic protein 7	99.77(n) 100(a)	458357 XM_001170064.1 XP_001170064.1
cow (Bos taurus)	BMP7¹	--	bone morphogenetic protein 7	92.73(n) 97.91(a)	540595 XM_612246.3 XP_612246.2
rat (Rattus norvegicus)	Bmp7¹	--	bone morphogenetic protein 7	86.38(n) 92.02(a)	85272 XM_342591.3 XP_342592.2
mouse (Mus musculus)	Bmp7^{1, 5}	2 (102.00 cM)⁵	bone morphogenetic protein 7^{1, 5}	90.93(n)¹ 97.67(a)¹	12162¹ NM_007557.2¹ NP_031583.2¹ AL929140⁵ BC010771⁵ (see all 6)

About this table Species with no ortholog for BMP7

ENSEMBL Gene Tree for BMP7

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BMP7 gene

BMP5² BMP6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/742 NCBI SNPs in BMP7 are shown (see all 742 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 293)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12438^1,2	A,C,F,H,O	55177312(-)	`CTCACA/GGCTGT`	1	--	ut3¹ ese³		17		MN NA EU EA WA	1700
	rs10375^1,2	A,C,F,H	55179088(-)	`GCGCCC/TACCAG`	1	--	ut3¹ ese³		12		MN EA EU WA NA	2608
	rs6014947^1,2	A,C,F,H	55177906(+)	`AGCCAC/TGTCAG`	1	--	ut3¹ ese³		12		EU EA WA NA	1048
	rs17480735^1,2	C,F,H	55178892(+)	`TTTACG/ACATCA`	1	--	ut3¹ ese³		7		NA EU EA WA	562
	rs6025415^1,2	F,H	55177794(+)	`AAAACG/CTTTGC`	1	--	ut3¹ ese³		4		EU EA WA	420
	rs6014946^1,2	F,H	55177718(+)	`GGAGAA/CACAGT`	1	--	ut3¹ ese³		4		EU EA WA	418
--	rs6025417^1,2	A	55178312(+)	`cctctC/Ggggtt`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs6025416^1,2	A	55178311(+)	`acctcC/CC /T/TGggggt`	1	--	ut3¹ ese³		0	--	--	--	--
	rs4141955^1,2	C	55177819(+)	`TCCCCG/TAGGCC`	1	--	ut3¹		0	--	--	--	--
--	rs6025418^1,2	A	55178480(+)	`ctcccA/Gaagtg`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for BMP7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 112267

10/68 Novoseek disease relationships for BMP7 gene (see all 68 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
renal fibrosis	72.18	11	18266088 (3), 15794307 (1), 17376778 (1), 19112509 (1) (see all 7)
degenerative spondylolisthesis	68.47	10	16371892 (2), 15672240 (1), 19092614 (1), 15534410 (1) (see all 7)
furcation defects	62.79	3	9526911 (2)
arthrodesis	45.54	12	19092614 (3), 12205422 (2), 10101812 (1), 17588821 (1) (see all 9)
spinal stenosis	43.24	10	15672240 (2), 12908103 (2), 10232555 (1), 17669279 (1) (see all 6)
osteosarcoma	42.39	24	9322936 (3), 9069169 (2), 10716620 (2), 9565067 (2) (see all 10)
spondylolisthesis	41.56	3	15672240 (1), 15534410 (1), 12908103 (1)
renal disease	40.54	40	15199292 (5), 18508541 (3), 16686760 (2), 12594282 (2) (see all 17)
pseudarthrosis	38.15	12	16601593 (3), 17977189 (2), 16365133 (1), 16510831 (1) (see all 5)
ossification heterotopic	35.29	2	19043134 (1), 17482003 (1)

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Human Gene Mutation Database: BMP7
Human Genome Epidemiology Navigator: BMP7 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/468 PubMed articles for BMP7 gene (see all 468 ):

Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily. (PubMed id 8570652)^{1, 3, 4} Griffith D.L.... Carlson W.D. (1996)
A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. (PubMed id 1427904)^{1, 2, 3} Hahn G.V....Kaplan F.S. (1992)
OP-1 cDNA encodes an osteogenic protein in the TGF-beta family. (PubMed id 2357959)^{1, 3, 4} Oezkaynak E.... Oppermann H. (1990)
Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. (PubMed id 2263636)^{1, 3, 4} Celeste A.J.... Wozney J.M. (1990)
USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. (PubMed id 15020244)^{3, 4} Yanagita M.... Sakurai T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Modulation of endogenous osteogenic protein-1 (OP-1) by interleukin-1 in adult human articular cartilage. (PubMed id 12925612)^{1, 3} Merrihew C....Chubinskaya S. (2003)
Age-related changes in cartilage endogenous osteogenic protein-1 (OP-1). (PubMed id 12385776)^{1, 3} Chubinskaya S....Kuettner K.E. (2002)
BMP7 influences proliferation, migration, and invasion of breast cancer cells. (PubMed id 18980801)^{1, 3} Alarmo E.L....Kallioniemi A. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 655	HGNC: 1074	AceView: BMP7	Ensembl:ENSG00000101144	euGenes: HUgn655
ECgene: BMP7	H-InvDB: BMP7

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BMP7	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_7

Licensable Technologies for BMP7
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BMP7:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BMP7-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BMP7		Antibodies for BMP7
	Explore super-pooled esiRNAs		Proteins for BMP7
	Lentivirus-delivered shRNAs for BMP7		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BMP7)
	Antibodies (BMP7)
	Chimera RNAi (BMP7)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for BMP7

	Recombinant Proteins (BMP7)
	Antibodies (BMP7)

Search OriGene for BMP7

Search Tocris compounds for BMP7

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BMP7

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
BMP7 Gene at Home site.
Version 2.41.1
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BMP7 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for BMP7

Summaries
for BMP7

Genomic Location
for BMP7

Proteins
for BMP7

Protein Domains/
Families
for BMP7

Gene Function
for BMP7

Pathways & Interactions
for BMP7

Drugs & Compounds
for BMP7

Transcripts
for BMP7

Expression
for BMP7

Orthologs
for BMP7

Paralogs
for BMP7

SNPs/Variants
for BMP7

Disorders & Mutations
for BMP7

Medical News
for BMP7

Publications
for BMP7

Search for BMP7

Genome Databases showing BMP7

Other Databases showing BMP7

Specialized Databases showing BMP7

Licensable Technologies
for BMP7

Services
for BMP7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BMP7 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor BMP7

Summariesfor BMP7

Genomic Locationfor BMP7

Proteinsfor BMP7

Protein Domains/Familiesfor BMP7

Gene Functionfor BMP7

Pathways & Interactionsfor BMP7

Drugs & Compoundsfor BMP7

Transcriptsfor BMP7

Expression for BMP7

Orthologsfor BMP7

Paralogsfor BMP7

SNPs/Variantsfor BMP7

Disorders & Mutationsfor BMP7

Medical Newsfor BMP7

Publicationsfor BMP7

Search for BMP7

Genome Databases showing BMP7

Other Databases showing BMP7

Specialized Databases showing BMP7

Licensable Technologiesfor BMP7

Servicesfor BMP7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BMP7

Summaries
for BMP7

Genomic Location
for BMP7

Proteins
for BMP7

Protein Domains/
Families
for BMP7

Gene Function
for BMP7

Pathways & Interactions
for BMP7

Drugs & Compounds
for BMP7

Transcripts
for BMP7

Expression
for BMP7

Orthologs
for BMP7

Paralogs
for BMP7

SNPs/Variants
for BMP7

Disorders & Mutations
for BMP7

Medical News
for BMP7

Publications
for BMP7

Licensable Technologies
for BMP7

Services
for BMP7