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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BMP6 Gene

protein-coding GIFtS: 65
GCID: GC06P007672

bone morphogenetic protein 6

(Previous name: vegetal related growth factor (TGFB-related) )
(Previous symbol: VGR)

Explore 294 diseases affiliated with
BMP6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Bone Morphogenetic Protein 6¹ ²		VG-1-R² ³
VGR¹ ² ³		VGR-1² ³
VGR1¹ ²		VG-1-Related Protein² ³
Vegetal Related Growth Factor (TGFB-Related)¹ ²		Vegetal-Related (TGFB Related) Cytokine²
BMP-6² ³		Vg1-Related Sequence²

External Ids:	HGNC: 1073¹	Entrez Gene: 654²	Ensembl: ENSG00000153162⁷	OMIM: 112266⁵	UniProtKB: P22004³

Export aliases for BMP6 gene to outside databases

Previous GC identifers: GC06P007712 GC06P007604

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BMP6:

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone

growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified

by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.

Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development.

In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone

inductive activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BMP6_HUMAN, P22004

Function: Induces cartilage and bone formation

Gene Wiki entry for BMP6 (Bone morphogenetic protein 6)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BMP6 gene promoter:
AP-1 p53 HTF ATF-2 PPAR-gamma1 c-Jun PPAR-gamma2 MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BMP6 promoter sequence

Search SABiosciences Chromatin IP Primers for BMP6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24-p23 Ensembl cytogenetic band: 6p24.3 HGNC cytogenetic band: 6p24-p23

BMP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP6 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P007672: view genomic region (about GC identifiers)

Start:	7,727,011 bp from pter	End:	7,881,961 bp from pter
Size:	154,951 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BMP6_HUMAN, P22004 (See protein sequence)

Recommended Name: Bone morphogenetic protein 6 precursor

Size: 513 amino acids; 57226 Da

Subunit: Interacts with SOSTDC1 (By similarity)

Subcellular location: Secreted (By similarity)

3 PDB 3D structures from and Proteopedia for BMP6:

2QCW (3D)

2R52 (3D)

2R53 (3D)

Secondary accessions: Q5TCP3

Explore the universe of human proteins at neXtProt for BMP6: NX_P22004

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P22004

BMP6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001709.1

ENSEMBL proteins:

ENSP00000283147

Human Recombinant Protein Products:

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	Uscn Proteins for BMP6

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0031988	membrane-bounded vesicle	IEA	--

BMP6 for ontologies About GeneDecksing

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Assay Products for BMP6:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BMP6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BMP6 for domains About GeneDecksing

4 InterPro domains/families:

IPR001111 TGF-b_N

IPR015615 TGF-beta-rel

IPR001839 TGF-b_C

IPR017948 TGFb_CS

Graphical View of Domain Structure for InterPro Entry P22004

ProtoNet protein and cluster: P22004

3 Blocks protein families:

IPB001111 Transforming growth factor beta (TGFb)

IPB001839 Transforming growth factor beta (TGFb)

IPB002400 Growth factor cystine knot superfamily signature

UniProtKB/Swiss-Prot: BMP6_HUMAN, P22004

Similarity: Belongs to the TGF-beta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BMP6_HUMAN, P22004

Function: Induces cartilage and bone formation

Genatlas biochemistry entry for BMP6:

bone morphogenetic protein 6 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),potential mediator of

skeletal metastases particularly in prostate carcinoma

Summary:

During embryonic development, BMP6 as signaling molecule is secreted from the following cells: Hypertrophic Chondrocytes in Thoracic Rib, Hypertrophic Chondrocytes in Lumbar Vertebrae (see all 6).

It affects the following cells: Hypertrophic Chondrocytes in Sacral Vertebrae, Hypertrophic Chondrocytes in Lumbar Vertebrae (see all 10).

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		hsa-miR-320a hsa-miR-3910 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-4263 hsa-miR-519a hsa-miR-4314 hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: BMP6 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP6

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005515	protein binding	--	--
GO:0008083	growth factor activity	IEA	--
GO:0046982	protein heterodimerization activity	IDA	7811286
GO:0070700	BMP receptor binding	IPI	7811286

BMP6 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for BMP6:

Increased cell death HMECs cel

Animal Models:
Mouse knock-out Bmp6^tm1Rob for BMP6
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Bmp6):

growth/size

reproductive system

skeleton

BMP6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

PEDF Induced Signaling

8/11 pathways (see all 11)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for BMP6

Selected targets of ESR1

5/69 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BMP6 (see all 69)

	Telomerase Components in Cell Signaling
	Molecular Mechanisms of Cancer
	eIF2 Pathway
	Intracellular Calcium Signaling
	JNK Pathway

3 BioSystems Pathways for BMP6

	Endochondral Ossification
	Id Signaling Pathway
	BMP receptor signaling

2 Kegg Pathways (Kegg details for BMP6):

	Hedgehog signaling pathway
	TGF-beta signaling pathway

BMP6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BMP6

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/18 Interacting proteins for BMP6 (P22004³ ENSP00000283147⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHRDL2	Q6WN34³, ENSP00000263671⁴	I2D: score=3 STRING: ENSP00000263671
BMPR1A	P36894³, ENSP00000224764⁴	I2D: score=2 STRING: ENSP00000224764
ACVR2B	Q13705³, ENSP00000340361⁴	I2D: score=1 STRING: ENSP00000340361
ACVR2A	P27037³, ENSP00000241416⁴	I2D: score=2 STRING: ENSP00000241416
BMPR2	Q13873³, ENSP00000363708⁴	I2D: score=2 STRING: ENSP00000363708

About this table

Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	8089189
GO:0001649	osteoblast differentiation	IEA	--
GO:0001654	eye development	IEA	--
GO:0001822	kidney development	IEA	--
GO:0001938	positive regulation of endothelial cell proliferation	IEA	--

BMP6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BMP6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BMP6
10/133 Novoseek chemical compound relationships for BMP6 gene (see all 133) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tgf beta1	83.9	27	9139748 (2), 15688013 (1), 10749622 (1), 11182753 (1) (see all 23)
threonine	69.4	104	8389764 (2), 1333888 (1), 8415726 (1), 8713111 (1) (see all 99)
serine	60.7	94	8389764 (2), 1333888 (1), 8713111 (1), 9023056 (1) (see all 90)
thymidine	60.1	38	11586262 (6), 8004589 (2), 8427046 (2), 2186011 (1) (see all 28)
vegf	59.2	144	8585929 (2), 18559616 (2), 16184456 (2), 7532545 (1) (see all 99)
procollagen	57.3	10	18188012 (1), 8435338 (1), 17586414 (1), 12434136 (1) (see all 10)
retinoic acid	53.5	110	12820386 (7), 8557779 (2), 2295827 (2), 7669719 (2) (see all 78)
pge2	50.9	106	1442930 (5), 8424130 (2), 15516833 (2), 1937965 (2) (see all 65)
ursinus	50.3	1	19897401 (1)
sb 203580	46.5	1	18252965 (1)

Search CenterWatch for drugs/clinical trials and news about BMP6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BMP6 gene:

NM_001718.4

Unigene Cluster for BMP6:

Bone morphogenetic protein 6

Hs.285671 [show with all ESTs]

Unigene Representative Sequence: NM_001718

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000283147(uc003mxu.4)

miRNA Products:		OriGene 3'-UTR Clone: BMP6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMP6
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		hsa-miR-320a hsa-miR-3910 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-4263 hsa-miR-519a hsa-miR-4314 hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: BMP6 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP6

Additional cDNA sequence:

AK300628.1 BC096084.2 BC096085.2 BC099624.1 BC099625.1 BC111763.1 BC112352.1 BC113018.1

BC113019.1 BC128031.1 M60315.1

10 DOTS entries:

DT.91771572 DT.121351994 DT.100877441 DT.121352081 DT.100877424 DT.70101960 DT.100877421 DT.454688

DT.99950472 DT.100650095

24/107 AceView cDNA sequences (see all 107):

BF732417 BF732376 AW298764 AI923557 BE551372 CD674151 AA836853 BF732719

BF434345 BE504255 CA442165 AA496287 BF593000 T27769 R27799 CB990163

BF732994 AI367148 AA424833 BF516507 AW854252 BQ006143 AA426586 N29100

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BMP6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTGGGAAG

About this image

BMP6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Autopod Growth Plate

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Cervical Vertebrae

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Lumbar Vertebrae

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Sacral Vertebrae

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Stylopod Growth Plate

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Thoracic Rib

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Thoracic Vertebrae

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Zeugopod Growth Plate

Hypertrophic Chondrocytes

Bone, Cartilage

Brain

Choroid Plexus

Choroid Plexus Progenitor Cells

Choroid Plexus

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Choroid Plexus

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

See BMP6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BMP6

SOURCE GeneReport for Unigene cluster: Hs.285671

SABiosciences Expression via Pathway-Focused PCR Arrays including BMP6 (see all 7):

Osteogenesis in human mouse rat

Growth Factors in human mouse rat

Hedgehog Signaling Pathway in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Mesenchymal Stem Cell in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for BMP6 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BMP6¹	bone morphogenetic protein 6	79.53(n) 85.46(a)		420868 XM_418956.3 XP_418956.3
lizard (Anolis carolinensis)	Reptilia	BMP6⁶	--	88(a)	1 ↔ 1	GL343209.1(855182-879795)
zebrafish (Danio rerio)	Actinopterygii	bmp6¹	bone morphogenetic protein 6	67.44(n) 69.51(a)		503761 NM_001013339.1 NP_001013357.1
fruit fly (Drosophila melanogaster)	Insecta	gbb^{1 , 3}	TGFbeta receptor signaling pathway transforming more³ glass bottom boat¹	34(a) (best of 2)³ 50.92(n)¹ 38.69(a)¹		37778¹ NM_057992.2¹ NP_477340.1¹
worm (Caenorhabditis elegans)	Secernentea	dbl-1³	TGF-beta-like growth factor	32(a)		V(6760886-6762540) --

ENSEMBL Gene Tree for BMP6 (if available)
TreeFam Gene Tree for BMP6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BMP6 gene

GDF5² GDF3² BMP5² GDF6² BMP8B² BMP4² GDF7² GDF2²

BMP2² BMP10² BMP3² BMP7² GDF10² GDF1² BMP8A²

12 SIMAP similar genes for BMP6 using alignment to 6 protein entries: BMP6_HUMAN (see all proteins):

BMP3 BMP5 BMP8A BMP7 DKFZp686A06204 TGFB1

GDF5 BMPY BMP8B TGFB3 BMP4 BMP2

BMP6 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for BMP6
PGOHUM00000246447

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148315995^1,2		--	7725015(+)	`ATCAGA/GTATTT`	1	--	us2k¹		0	--	--	--	--
rs77635946^1,2		--	7725128(+)	`ACCCAT/CGAGAA`	1	--	us2k¹		3		CSA WA	121
rs141425602^1,2		--	7725261(+)	`GACCAC/TTTGGA`	1	--	us2k¹		0	--	--	--	--
rs6937763^1,2	C,F,	--	7725394(+)	`TCGGGC/TGGGGT`	1	--	us2k¹		1		WA	118
rs180939966^1,2		--	7725425(+)	`CCTCAC/TTGGCA`	1	--	us2k¹		0	--	--	--	--
rs6936638^1,2	C,F,	--	7725457(+)	`ATCTTG/ATCTAA`	1	--	us2k¹		1		WA	118
rs3812163^1,2	C,F,A,H,	--	7725760(-)	`TGTGTT/AGACTT`	1	--	us2k¹		28		NS EA NA WA CSA	2710
rs186315958^1,2		--	7725995(+)	`ATCGCC/TGTTAT`	1	--	us2k¹		0	--	--	--	--
rs191163703^1,2		--	7726053(+)	`AAAAGA/GGAAAG`	1	--	us2k¹		0	--	--	--	--
rs1107495^1,2	C,F,A,H,	--	7726057(+)	`GAGAAA/GGCTTC`	1	--	us2k¹		28		NA EA MN NS WA	3365

HapMap Linkage Disequilibrium report for BMP6 (7727011 - 7881961 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for BMP6
2 CNVs: 64422 7588
2 Indels: 64423 12802

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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BMP6 for disorders           About GeneDecksing

OMIM gene information: 112266    OMIM disorders: --

20/294 diseases for BMP6 (see all 294):    About MalaCards

alpha 1-antitrypsin deficiency estrogen-receptor positive breast cancer mycobacterium avium complex disease porphyria cutanea tarda

cutis laxa skeletal muscle regeneration focal segmental glomerulosclerosis glycogen storage disease

dupuytren contracture glycogen storage disease i otitis media connective tissue disease

graft versus host disease non-small cell lung carcinoma aortic aneurysm thoracic aortic aneurysm

bronchiolitis obliterans adenomatous polyposis coli diastolic heart failure abdominal aortic aneurysm

1 disease from the University of Copenhagen DISEASES database for BMP6:

Hemochromatosis

10/97 Novoseek disease relationships for BMP6 gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	78	805	1442930 (4), 9369823 (4), 1937392 (4), 1458474 (3) (see all 99)
tumors	74.9	1040	1442930 (4), 9369823 (4), 10582704 (4), 1937392 (4) (see all 99)
renal fibrosis	72.1	17	10515378 (1), 11287759 (1), 15090860 (1), 15906952 (1) (see all 16)
glomerulosclerosis	66.7	24	9072884 (1), 10405207 (1), 18039119 (1), 7922170 (1) (see all 23)
sclerosis systemic	65.5	41	11918720 (2), 15577613 (2), 10817561 (2), 15133694 (2) (see all 30)
pulmonary fibrosis	63	24	12816730 (2), 11259398 (1), 18583319 (1), 9820652 (1) (see all 22)
diabetic nephropathies	62.2	46	12453917 (2), 11706299 (2), 10585634 (1), 11576897 (1) (see all 44)
inflammation	61.7	102	16799084 (2), 1569205 (1), 10469047 (1), 11966931 (1) (see all 97)
telangiectasia hereditary hemorrhagic	61.4	12	12667943 (2), 16121312 (1), 12393874 (1), 20042709 (1) (see all 11)
skin fibrosis	59.3	2	15026552 (1), 10400038 (1)

Human Genome Epidemiology (HuGE) Navigator: BMP6 (12 documents)

Export disorders for BMP6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BMP6 gene, integrated from 9 sources (see all 3435):
(articles sorted by number of sources associating them with BMP6)

Utopia: connect your pdf to the dynamic
world of online information

A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. (PubMed id 1427904)^{1, 3, 9} Hahn G.V....Kaplan F.S. (1992)
BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. (PubMed id 17924656)^{1, 2, 9} Allendorph G.P....Choe S. (2007)
Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. (PubMed id 2263636)^{1, 2, 9} Celeste A.J.... Wozney J.M. (1990)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines. (PubMed id 1453478)^{1, 3} Sauermann U....Schluesener H.J. (1992)
Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro. (PubMed id 13130469)^{1, 9} Bobacz K....Graninger W.B. (2003)
Bone morphogenetic protein-6 is a marker of serous acinar cell differentiation in normal and neoplastic human salivary gland. (PubMed id 10582704)^{1, 9} Heikinheimo K.A....Heikinheimo A.K. (1999)
BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1. (PubMed id 19308091)^{1, 9} Du J....Zhu T. (2009)
The prognostic significance of BMP-6 signaling in prostate cancer. (PubMed id 18931653)^{1, 9} Yuen H.F....Chan K.W. (2008)
Bone morphogenetic protein 6 inhibit stress-induced breast cancer cells apoptosis via both Smad and p38 pathways. (PubMed id 17879955)^{1, 9} Du J....Zhu T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 654	HGNC: 1073	AceView: BMP6	Ensembl:ENSG00000153162	euGenes: HUgn654
ECgene: BMP6	Kegg: 654	H-InvDB: BMP6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BMP6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BMP6	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_6

Intellectual Property for BMP6 gene
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Patent Information for BMP6 gene:
Search GeneIP for patents involving BMP6

GeneCards and IP:
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bone morphogenetic protein 6

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BMP6 Gene

bone morphogenetic protein 6

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