Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BMP6 Gene

protein-coding   GIFtS: 64
GCID: GC06P007672

Bone Morphogenetic Protein 6

(Previous name: vegetal related growth factor (TGFB-related))
(Previous symbol: VGR)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bone Morphogenetic Protein 61 2     VGR-12 3
VGR1 2 3     VG-1-Related Protein2 3
Vegetal Related Growth Factor (TGFB-Related)1 2     VGR12
BMP-62 3     Vegetal-Related (TGFB Related) Cytokine2
VG-1-R2 3     Vg1-Related Sequence2

External Ids:    HGNC: 10731   Entrez Gene: 6542   Ensembl: ENSG000001531627   OMIM: 1122665   UniProtKB: P220043   

Export aliases for BMP6 gene to outside databases

Previous GC identifers: GC06P007712 GC06P007604


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BMP6 Gene:
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone
growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally
identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an
extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed
role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to
speculation of possible bone inductive activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for BMP6 Gene: 
BMP6 (bone morphogenetic protein 6) is a protein-coding gene. Diseases associated with BMP6 include glycogen storage disease i, and cecum cancer, and among its related super-pathways are Rac1 Pathway and MIF Mediated Glucocorticoid Regulation. GO annotations related to this gene include cytokine activity and protein heterodimerization activity. An important paralog of this gene is GDF5.

UniProtKB/Swiss-Prot: BMP6_HUMAN, P22004
Function: Induces cartilage and bone formation

Gene Wiki entry for BMP6 (Bone morphogenetic protein 6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMP6 gene promoter:
         AP-1   p53   HTF   ATF-2   PPAR-gamma1   c-Jun   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for BMP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24-p23   Ensembl cytogenetic band:  6p24.3   HGNC cytogenetic band: 6p24-p23

BMP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P007672:  view genomic region     (about GC identifiers)

Start:
7,727,011 bp from pter      End:
7,881,961 bp from pter
Size:
154,951 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BMP6_HUMAN, P22004 (See protein sequence)
Recommended Name: Bone morphogenetic protein 6 precursor  
Size: 513 amino acids; 57226 Da
Subunit: Interacts with SOSTDC1 (By similarity)
Subcellular location: Secreted (By similarity)
3 PDB 3D structures from and Proteopedia for BMP6:
2QCW (3D)        2R52 (3D)        2R53 (3D)    
Secondary accessions: Q5TCP3

Explore the universe of human proteins at neXtProt for BMP6: NX_P22004

Explore proteomics data for BMP6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22004

  • BMP6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BMP6 Protein Expression
    REFSEQ proteins: NP_001709.1  
    ENSEMBL proteins: 
     ENSP00000283147  

    Human Recombinant Protein Products for BMP6: 
    EMD Millipore Purified and/or Recombinant BMP6 Protein
    R&D Systems Recombinant & Natural Proteins for BMP6 (BMP-6)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for BMP6
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for BMP6
    GenScript Custom Purified and Recombinant Proteins Services for BMP6
    Novus Biologicals BMP6 Proteins
    Novus Biologicals BMP6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for BMP6
    Cloud-Clone Corp. Proteins for BMP6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--
    GO:0031988membrane-bounded vesicle IEA--

    BMP6 for ontologies           About GeneDecksing



    BMP6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BMP6
    R&D Systems Antibodies for BMP6 (BMP-6)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BMP6
    GenScript Custom Superior Antibodies Services for BMP6
    Novus Biologicals BMP6 Antibodies
    Abcam antibodies for BMP6
    Cloud-Clone Corp. Antibodies for BMP6 
    ThermoFisher Antibodies for BMP6
    LSBio Antibodies in human, mouse, rat for BMP6 

    Assay Products for BMP6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BMP6
    R&D Systems ELISAs for BMP6 (BMP-6)
    GenScript Custom Assay Services for BMP6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BMP6 
    Cloud-Clone Corp. CLIAs for BMP6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BMP: Bone morphogenetic proteins

    4 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P22004

    ProtoNet protein and cluster: P22004

    3 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: BMP6_HUMAN, P22004
    Similarity: Belongs to the TGF-beta family


    BMP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP6_HUMAN, P22004
    Function: Induces cartilage and bone formation

         Genatlas biochemistry entry for BMP6:
    bone morphogenetic protein 6 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),potential
    mediator of skeletal metastases particularly in prostate carcinoma

         Summary:
    During embryonic development, BMP6 as signaling molecule is secreted from the following cells: Hypertrophic Chondrocytes in Thoracic Vertebrae, Hypertrophic Chondrocytes in Sacral Vertebrae (see all 6).

    It affects the following cells: Hypertrophic Chondrocytes in Thoracic Rib, Hypertrophic Chondrocytes in Sacral Vertebrae (see all 10).

    BMP6 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Chondrocyte-like cells from Bone (see all 10).

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
    GO:0046982protein heterodimerization activity IDA7811286
    GO:0070700BMP receptor binding IPI7811286
         
    BMP6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BMP6:
     Increased cell death HMECs cel 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bmp6):
     growth/size  reproductive system  skeleton 

    BMP6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bmp6tm1Rob for BMP6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BMP6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BMP6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BMP6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BMP6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMP6
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP6 (see all 28):
    hsa-miR-320a hsa-miR-3910 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-4263 hsa-miR-519a hsa-miR-4314 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidBMP6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BMP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BMP6
    Sirion Biotech Customized adenovirus for overexpression of BMP6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BMP6 (see all 7)
    OriGene ORF clones in mouse, rat for BMP6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP6 (NM_001718)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP6
    Sirion Biotech Customized lentivirus for stable overexpression of BMP6 
                         Customized lentivirus expression plasmids for stable overexpression of BMP6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BMP6
    Search LifeMap BioReagents cell lines for BMP6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BMP6 About   (see all 22)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for BMP6
        Selected targets of ESR1

    5/69 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BMP6 (see all 69)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    3 BioSystems Pathways for BMP6
        Endochondral Ossification
    Id Signaling Pathway
    BMP receptor signaling


    3         Kegg Pathways  (Kegg details for BMP6):
        TGF-beta signaling pathway
    Hippo signaling pathway
    Ovarian steroidogenesis


    BMP6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BMP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for BMP6 (P220043 ENSP000002831474) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHRDL2Q6WN343, ENSP000002636714I2D: score=3 STRING: ENSP00000263671
    ACVR2BQ137053, ENSP000003403614I2D: score=1 STRING: ENSP00000340361
    ACVR2AP270373, ENSP000002414164I2D: score=2 STRING: ENSP00000241416
    BMPR2Q138733, ENSP000003637084I2D: score=2 STRING: ENSP00000363708
    BMPERQ8N8U93, ENSP000002971614I2D: score=1 STRING: ENSP00000297161
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8089189
    GO:0001649osteoblast differentiation IEA--
    GO:0001654eye development IEA--
    GO:0001822kidney development IEA--
    GO:0001938positive regulation of endothelial cell proliferation IEA--

    BMP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BMP6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BMP6

    10/133 Novoseek inferred chemical compound relationships for BMP6 gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgf beta1 83.9 27 9139748 (2), 15688013 (1), 10749622 (1), 11182753 (1) (see all 23)
    threonine 69.4 104 8389764 (2), 1333888 (1), 8415726 (1), 8713111 (1) (see all 99)
    serine 60.7 94 8389764 (2), 1333888 (1), 8713111 (1), 9023056 (1) (see all 90)
    thymidine 60.1 38 11586262 (6), 8004589 (2), 8427046 (2), 2186011 (1) (see all 28)
    vegf 59.2 144 8585929 (2), 18559616 (2), 16184456 (2), 7532545 (1) (see all 99)
    procollagen 57.3 10 18188012 (1), 8435338 (1), 17586414 (1), 12434136 (1) (see all 10)
    retinoic acid 53.5 110 12820386 (7), 8557779 (2), 2295827 (2), 7669719 (2) (see all 78)
    pge2 50.9 106 1442930 (5), 8424130 (2), 15516833 (2), 1937965 (2) (see all 65)
    ursinus 50.3 1 19897401 (1)
    sb 203580 46.5 1 18252965 (1)

    Search CenterWatch for drugs/clinical trials and news about BMP6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BMP6 gene: 
    NM_001718.4  

    Unigene Cluster for BMP6:

    Bone morphogenetic protein 6
    Hs.285671  [show with all ESTs]
    Unigene Representative Sequence: NM_001718
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000283147(uc003mxu.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMP6
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP6 (see all 28):
    hsa-miR-320a hsa-miR-3910 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-4263 hsa-miR-519a hsa-miR-4314 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidBMP6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BMP6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP6
    Clone
    Products:
         
    OriGene clones in human, mouse for BMP6 (see all 7)
    OriGene ORF clones in mouse, rat for BMP6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP6 (NM_001718)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP6
    Sirion Biotech Customized lentivirus for stable overexpression of BMP6 
                         Customized lentivirus expression plasmids for stable overexpression of BMP6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BMP6
    OriGene qSTAR qPCR primer pairs in human, mouse for BMP6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BMP6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP6

    Additional mRNA sequence: 

    AK300628.1 BC096084.2 BC096085.2 BC099624.1 BC099625.1 BC111763.1 BC112352.1 BC113018.1 
    BC113019.1 BC128031.1 M60315.1 

    10 DOTS entries:

    DT.91771572  DT.121351994  DT.100877441  DT.121352081  DT.100877424  DT.70101960  DT.100877421  DT.454688 
    DT.99950472  DT.100650095 

    24/107 AceView cDNA sequences (see all 107):

    BE504255 BF732417 BF732376 BE551372 AI923557 AA836853 CA442165 AW298764 
    CD674151 BF593000 BF434345 AA496287 BF732719 AW951999 AW854252 BQ006143 
    AI367148 N29100 BF516507 CD245160 BM920942 AA426586 AA424833 BG284033 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BMP6 expression in normal human tissues (normalized intensities)      BMP6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTGGGAAG
    BMP6 Expression
    About this image


    BMP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 23 entries
             PureStem endothelial progenitor 30-SM2-1
             Human Ovarian Microvascular Endothelial Cells (HOMEC)   
             huvec   
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Thalamus
             Human Brain Microvascular Endothelial Cells (HBMEC)   
             Olfactory Bulb   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 10 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
             fetal cartilage   
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 5 entries
             Wharton's jelly-derived stem cells
             Human Umbilical Vein Endothelial Cells (HUVEC) (BioTime)   
             huvec   

    See BMP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BMP6

    SOURCE GeneReport for Unigene cluster: Hs.285671
        SABiosciences Expression via Pathway-Focused PCR Arrays including BMP6 (see all 7): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BMP6
    OriGene qSTAR qPCR primer pairs in human, mouse for BMP6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BMP6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BMP6 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp61 , 5 bone morphogenetic protein 61, 5 88.34(n)1
    91.94(a)1
      13 (18.15 cM)5
    121611  NM_007556.21  NP_031582.11 
     383457165 
    chicken
    (Gallus gallus)
    Aves BMP61 bone morphogenetic protein 6 79.53(n)
    85.46(a)
      420868  XM_418956.3  XP_418956.3 
    lizard
    (Anolis carolinensis)
    Reptilia BMP66
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL343209.1(855182-879795)
    zebrafish
    (Danio rerio)
    Actinopterygii bmp61 bone morphogenetic protein 6 67.44(n)
    69.51(a)
      503761  NM_001013339.1  NP_001013357.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gbb1 , 3 TGFbeta receptor signaling pathway
    transforming more3
    glass bottom boat1
    34(a)
    (best of 2)3
    50.92(n)1
    38.69(a)1
      377781  NM_057992.21  NP_477340.11 


    ENSEMBL Gene Tree for BMP6 (if available)
    TreeFam Gene Tree for BMP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BMP6 gene
    GDF52  BMP52  GDF32  BMP8B2  GDF62  BMP42  GDF72  GDF22  
    BMP22  BMP102  BMP32  BMP72  GDF102  GDF12  BMP8A2  
    11 SIMAP similar genes for BMP6 using alignment to 6 protein entries:     BMP6_HUMAN (see all proteins):
    BMP3    BMP5    BMP8A    BMP7    DKFZp686A06204    TGFB1
    GDF5    BMPY    BMP8B    TGFB3    BMP4

    BMP6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BMP6
    PGOHUM00000246447


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3374 SNPs in BMP6 are shown (see all 3374)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362004
    A colorectal cancer sample4--see VAR_0362002 A D mis40--------
    VAR_0362014
    A colorectal cancer sample4--see VAR_0362012 P L mis40--------
    rs358269151,2
    C--7610246(+) TTTTT-/TAAGAC 1 -- int10--------
    rs681101631,2
    C--7693226(+) AAACA-/GAACATA 1 -- int11Minor allele frequency- GA:0.00NA 2
    rs1483159951,2
    --7725015(+) ATCAGA/GTATTT 1 -- us2k10--------
    rs776359461,2
    C,F--7725128(+) ACCCAT/CGAGAA 1 -- us2k13Minor allele frequency- C:0.10CSA WA 121
    rs1414256021,2
    C--7725261(+) GACCAC/TTTGGA 1 -- us2k10--------
    rs69377631,2
    C,F--7725394(+) TCGGGC/TGGGGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1809399661,2
    --7725425(+) CCTCAC/TTGGCA 1 -- us2k10--------
    rs69366381,2
    C,F--7725457(+) ATCTTG/ATCTAA 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for BMP6 (7727011 - 7881961 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for BMP6 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678437CNV Deletion23128226
    esv2731543CNV Deletion23290073
    esv2656550CNV Deletion23128226
    esv2731542CNV Deletion23290073
    esv2658602CNV Deletion23128226
    esv2731544CNV Deletion23290073
    nsv462625CNV Loss19166990
    nsv525566CNV Loss19592680
    nsv830582CNV Loss17160897
    nsv526828CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BMP6
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 112266    OMIM disorders: --

    20/255 diseases for BMP6 (see all 255):    About MalaCards
    glycogen storage disease i    cecum cancer    bone marrow necrosis    cellular leiomyoma
    diffuse scleroderma    mycobacterium avium complex disease    intestinal neoplasm    rasmussen encephalitis
    pancreas adenocarcinoma    telangiectasis    juvenile nasopharyngeal angiofibroma    breast cyst
    iga glomerulonephritis    myelofibrosis    hypertrophic scars    marfan syndrome
    pneumoconiosis    hereditary hemorrhagic telangiectasia    bronchiolitis obliterans    localized scleroderma

    1 disease from the University of Copenhagen DISEASES database for BMP6:
    Hemochromatosis

    BMP6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/97 Novoseek inferred disease relationships for BMP6 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 78 805 1442930 (4), 9369823 (4), 1937392 (4), 1458474 (3) (see all 99)
    tumors 74.9 1040 1442930 (4), 9369823 (4), 10582704 (4), 1937392 (4) (see all 99)
    renal fibrosis 72.1 17 10515378 (1), 11287759 (1), 15090860 (1), 15906952 (1) (see all 16)
    glomerulosclerosis 66.7 24 9072884 (1), 10405207 (1), 18039119 (1), 7922170 (1) (see all 23)
    sclerosis systemic 65.5 41 11918720 (2), 15577613 (2), 10817561 (2), 15133694 (2) (see all 30)
    pulmonary fibrosis 63 24 12816730 (2), 11259398 (1), 18583319 (1), 9820652 (1) (see all 22)
    diabetic nephropathies 62.2 46 12453917 (2), 11706299 (2), 10585634 (1), 11576897 (1) (see all 44)
    inflammation 61.7 102 16799084 (2), 1569205 (1), 10469047 (1), 11966931 (1) (see all 97)
    telangiectasia hereditary hemorrhagic 61.4 12 12667943 (2), 16121312 (1), 12393874 (1), 20042709 (1) (see all 11)
    skin fibrosis 59.3 2 15026552 (1), 10400038 (1)

    Genetic Association Database (GAD): BMP6
    Human Genome Epidemiology (HuGE) Navigator: BMP6 (12 documents)

    Export disorders for BMP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BMP6 gene, integrated from 9 sources (see all 3440):
    (articles sorted by number of sources associating them with BMP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. (PubMed id 1427904)1, 3, 9 Hahn G.V....Kaplan F.S. (1992)
    2. Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. (PubMed id 18187665)1, 4, 9 Ashley-Koch A.E....Telen M.J. (2008)
    3. BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. (PubMed id 17924656)1, 2, 9 Allendorph G.P....Choe S. (2007)
    4. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. (PubMed id 2263636)1, 2, 9 Celeste A.J.... Wozney J.M. (1990)
    5. Genome wide study of maternal and parent-of-origin eff ects on the etiology of orofacial clefts. (PubMed id 22419666)1, 4 Shi M....Beaty T.H. (2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
    8. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
    9. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    10. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 654 HGNC: 1073 AceView: BMP6 Ensembl:ENSG00000153162 euGenes: HUgn654
    ECgene: BMP6 Kegg: 654 H-InvDB: BMP6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BMP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP6 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_6

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BMP6 gene:
    Search GeneIP for patents involving BMP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of BMP6
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant BMP6 Protein
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for BMP6 (BMP-6)   Browse Cell Culture Products  
     ELISAs for BMP6 (BMP-6)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for BMP6 (BMP-6)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for BMP6  
     OriGene qPCR primer pairs and template standards for BMP6   OriGene Protein Over-expression Lysate for BMP6  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for BMP6  
     OriGene qSTAR qPCR primer pairs in human, mouse for BMP6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for BMP6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BMP6   OriGene Custom Protein Services for BMP6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BMP6
     QIAGEN SeqTarget long-range PCR primers for resequencing BMP6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP6
     GenScript Custom Purified and Recombinant Proteins Services for BMP6 GenScript cDNA clones with any tag delivered in your preferred vector for BMP6
     GenScript Custom Assay Services for BMP6 GenScript Custom Superior Antibodies Services for BMP6
     GenScript Custom overexpressing Cell Line Services for BMP6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BMP6 promoter
     Search Chromatin IP Primers for BMP6
     RT2 qPCR Primer Assay in human, mouse, rat BMP6
     GNC Network for BMP6
     SABiosciences PCR Arrays including human, mouse, rat BMP6
     Search Tocris compounds for BMP6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BMP6 antibodies
     BMP6 proteins
     BMP6 lysates
     Antibodies for BMP6
     See all of Abcam's Antibodies, Kits and Proteins for BMP6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for BMP6




     Proteins for BMP6
     Antibodies for BMP6
     ELISAs for BMP6
     CLIAs for BMP6
     Search LifeMap BioReagents cell lines for BMP6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP6
     SwitchGear 3'UTR luciferase reporter plasmids for BMP6
     SwitchGear Promoter luciferase reporter plasmids for BMP6
     ThermoFisher Antibodies for BMP6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for BMP6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BMP6
    Customized:
     lentivirus for stable overexpression of BMP6
     lentivirus expression plasmids for stable overexpression of BMP6
     adenovirus for overexpression of BMP6
     LSBio Antibodies in human, mouse, rat for BMP6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BMP6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4