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Aliases for BMP6 Gene

Aliases for BMP6 Gene

  • Bone Morphogenetic Protein 6 2 3 5
  • Vegetal Related Growth Factor (TGFB-Related) 2 3
  • VG-1-Related Protein 3 4
  • VG-1-R 3 4
  • BMP-6 3 4
  • VGR-1 3 4
  • VGR 3 4
  • Vegetal-Related (TGFB Related) Cytokine 3
  • Vg1-Related Sequence 3
  • VGR1 3

External Ids for BMP6 Gene

Previous HGNC Symbols for BMP6 Gene

  • VGR

Previous GeneCards Identifiers for BMP6 Gene

  • GC06P007712
  • GC06P007672
  • GC06P007604

Summaries for BMP6 Gene

Entrez Gene Summary for BMP6 Gene

  • The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for BMP6 Gene

BMP6 (Bone Morphogenetic Protein 6) is a Protein Coding gene. Diseases associated with BMP6 include Bone Marrow Necrosis and Hypertrophic Scars. Among its related pathways are p70S6K Signaling and Endochondral Ossification. GO annotations related to this gene include protein heterodimerization activity and growth factor activity. An important paralog of this gene is BMP2.

UniProtKB/Swiss-Prot for BMP6 Gene

  • Induces cartilage and bone formation.

Gene Wiki entry for BMP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP6 Gene

Genomics for BMP6 Gene

Regulatory Elements for BMP6 Gene

Enhancers for BMP6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BMP6 on UCSC Golden Path with GeneCards custom track

Promoters for BMP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BMP6 on UCSC Golden Path with GeneCards custom track

Genomic Location for BMP6 Gene

7,726,778 bp from pter
7,881,728 bp from pter
154,951 bases
Plus strand

Genomic View for BMP6 Gene

Genes around BMP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BMP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BMP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP6 Gene

Proteins for BMP6 Gene

  • Protein details for BMP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bone morphogenetic protein 6
    Protein Accession:
    Secondary Accessions:
    • Q5TCP3

    Protein attributes for BMP6 Gene

    513 amino acids
    Molecular mass:
    57226 Da
    Quaternary structure:
    • Interacts with SOSTDC1.

    Three dimensional structures from OCA and Proteopedia for BMP6 Gene

neXtProt entry for BMP6 Gene

Proteomics data for BMP6 Gene at MOPED

Post-translational modifications for BMP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BMP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BMP6 (BMP6)

No data available for DME Specific Peptides for BMP6 Gene

Domains & Families for BMP6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TGF-beta family.
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with BMP6: view

Function for BMP6 Gene

Molecular function for BMP6 Gene

GENATLAS Biochemistry:
bone morphogenetic protein 6 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),potential mediator of skeletal metastases particularly in prostate carcinoma
UniProtKB/Swiss-Prot Function:
Induces cartilage and bone formation.

LifeMap Function Summary for BMP6 Gene

During embryonic development, BMP6 as signaling molecule is secreted from the following cells
BMP6 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for BMP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005160 transforming growth factor beta receptor binding IBA --
genes like me logo Genes that share ontologies with BMP6: view
genes like me logo Genes that share phenotypes with BMP6: view

Animal Models for BMP6 Gene

MGI Knock Outs for BMP6:

Animal Model Products

  • Taconic Biosciences Mouse Models for BMP6

miRNA for BMP6 Gene

miRTarBase miRNAs that target BMP6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BMP6 Gene

Localization for BMP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP6 Gene


Subcellular locations from

Jensen Localization Image for BMP6 Gene COMPARTMENTS Subcellular localization image for BMP6 gene
Compartment Confidence
extracellular 4
cytosol 3
mitochondrion 3
plasma membrane 2
cytoskeleton 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BMP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031988 membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with BMP6: view

Pathways & Interactions for BMP6 Gene

genes like me logo Genes that share pathways with BMP6: view

Gene Ontology (GO) - Biological Process for BMP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001501 skeletal system development TAS 8089189
GO:0001503 ossification IEA --
GO:0001654 eye development IEA --
GO:0001938 positive regulation of endothelial cell proliferation IEA --
genes like me logo Genes that share ontologies with BMP6: view

No data available for SIGNOR curated interactions for BMP6 Gene

Drugs & Compounds for BMP6 Gene

(76) Drugs for BMP6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(57) Additional Compounds for BMP6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BMP6: view

Transcripts for BMP6 Gene

mRNA/cDNA for BMP6 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(107) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BMP6 Gene

Bone morphogenetic protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BMP6 Gene

No ASD Table

Relevant External Links for BMP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BMP6 Gene

mRNA expression in normal human tissues for BMP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BMP6 Gene

This gene is overexpressed in Heart (48.6) and Peripheral blood mononuclear cells (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BMP6 Gene

SOURCE GeneReport for Unigene cluster for BMP6 Gene Hs.285671

genes like me logo Genes that share expression patterns with BMP6: view

Protein tissue co-expression partners for BMP6 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BMP6 Gene

Orthologs for BMP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for BMP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BMP6 35
  • 85.99 (n)
  • 87.07 (a)
BMP6 36
  • 88 (a)
(Mus musculus)
Mammalia Bmp6 35
  • 86.51 (n)
  • 89.19 (a)
Bmp6 16
Bmp6 36
  • 92 (a)
(Pan troglodytes)
Mammalia BMP6 35
  • 99.48 (n)
  • 99.61 (a)
BMP6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Bmp6 35
  • 85.11 (n)
  • 88.54 (a)
(Canis familiaris)
Mammalia BMP6 36
  • 89 (a)
(Monodelphis domestica)
Mammalia BMP6 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia BMP6 36
  • 91 (a)
(Gallus gallus)
Aves BMP6 35
  • 79.8 (n)
  • 86.11 (a)
BMP6 36
  • 84 (a)
(Anolis carolinensis)
Reptilia BMP6 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp6 35
  • 73.4 (n)
  • 81.03 (a)
(Danio rerio)
Actinopterygii bmp6 35
  • 67.27 (n)
  • 68.65 (a)
bmp6 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta gbb 37
  • 34 (a)
scw 37
  • 29 (a)
(Caenorhabditis elegans)
Secernentea dbl-1 37
  • 32 (a)
Species with no ortholog for BMP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP6 Gene

Gene Tree for BMP6 (if available)
Gene Tree for BMP6 (if available)

Paralogs for BMP6 Gene

Paralogs for BMP6 Gene

(12) SIMAP similar genes for BMP6 Gene using alignment to 6 proteins: Pseudogenes for BMP6 Gene

genes like me logo Genes that share paralogs with BMP6: view

Variants for BMP6 Gene

Sequence variations from dbSNP and Humsavar for BMP6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036200 A colorectal cancer sample
VAR_036201 A colorectal cancer sample
rs10458105 - 7,845,244(+) AATTC(C/T)GCATC reference, missense
rs1122669 -- 7,864,356(-) aggca(C/T)tcatc intron-variant
rs1150890 -- 7,796,880(+) ATTCA(A/T)AGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BMP6 Gene

Variant ID Type Subtype PubMed ID
nsv830582 CNV Loss 17160897
esv33520 CNV Gain 17666407
nsv525566 CNV Loss 19592680
nsv348521 CNV Loss 16902084
esv2731542 CNV Deletion 23290073
esv2658602 CNV Deletion 23128226
esv28982 CNV Loss 19812545
esv2731543 CNV Deletion 23290073
esv2656550 CNV Deletion 23128226
nsv526828 CNV Loss 19592680
nsv522173 CNV Loss 19592680
esv25960 CNV Gain 19812545
esv2678437 CNV Deletion 23128226
esv2731544 CNV Deletion 23290073
nsv462625 CNV Loss 19166990

Variation tolerance for BMP6 Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.57; 86.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BMP6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMP6 Gene

Disorders for BMP6 Gene

MalaCards: The human disease database

(22) MalaCards diseases for BMP6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bone marrow necrosis
hypertrophic scars
  • scars hypertrophic
renal fibrosis
hereditary hemorrhagic telangiectasia
  • osler hemorrhagic telangiectasia syndrome
  • agnogenic myeloid metaplasia
- elite association - COSMIC cancer census association via MalaCards
Search BMP6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BMP6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BMP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BMP6 Gene

Publications for BMP6 Gene

  1. A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. (PMID: 1427904) Hahn G.V. … Kaplan F.S. (Genomics 1992) 2 3 23 67
  2. Dual mechanism of deltaEF1 expression regulated by bone morphogenetic protein-6 in breast cancer. (PMID: 18805502) Yang S. … Zhu T. (Int. J. Biochem. Cell Biol. 2009) 3 23
  3. BMP6 attenuates oxidant injury in HK-2 cells via Smad-dependent HO-1 induction. (PMID: 19245827) Yan J. … Zhu T. (Free Radic. Biol. Med. 2009) 3 23
  4. BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1. (PMID: 19308091) Du J. … Zhu T. (Cell Res. 2009) 3 23
  5. Immunolocalization and mRNA expression of bone morphogenetic protein-6 in human clear cell renal carcinoma. (PMID: 20016212) Basic-Jukic N. … Kes P. (Kidney Blood Press. Res. 2009) 3 23

Products for BMP6 Gene

Sources for BMP6 Gene