External Ids for BMP5 Gene
Previous GeneCards Identifiers for BMP5 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]
GeneCards Summary for BMP5 Gene
BMP5 (Bone Morphogenetic Protein 5) is a Protein Coding gene. Diseases associated with BMP5 include Keshan Disease and Epileptic Encephalopathy, Childhood-Onset. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include cytokine activity and transforming growth factor beta receptor binding. An important paralog of this gene is BMP7.
UniProtKB/Swiss-Prot for BMP5 Gene
Induces cartilage and bone formation.