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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BMP5 Gene

protein-coding   GIFtS: 66
GCID: GC06M055667

bone morphogenetic protein 5
 Explore 26 diseases affiliated with
BMP5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BMP5    

Aliases
for BMP5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Bone Morphogenetic Protein 51 2
BMP-52 3

External Ids:    HGNC: 10721   Entrez Gene: 6532   Ensembl: ENSG000001121757   OMIM: 1122655   UniProtKB: P220033   

Export aliases for BMP5 gene to outside databases

Previous GC identifers: GC06M055622 GC06M055728 GC06M055455


Summaries
for BMP5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BMP5:
This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth
factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone
morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral
osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then
processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular
meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially
regulated during the formation of various tumors. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BMP5_HUMAN, P22003
Function: Induces cartilage and bone formation

Gene Wiki entry for BMP5 (Bone morphogenetic protein 5)


Genomic Views
for BMP5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMP5 gene promoter:
         c-Fos   AML1a   SREBP-1c   Nkx2-2   Nkx2-5   SREBP-1b   SREBP-1a   HFH-1   c-Jun   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BMP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for BMP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.1   HGNC cytogenetic band: 6p12.1

BMP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M055667:  view genomic region     (about GC identifiers)

Start:
 55,618,443 bp from pter      End:
 55,740,375 bp from pter
Size:
 121,933 bases      Orientation:
 minus strand

Proteins
for BMP5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BMP5_HUMAN, P22003 (See protein sequence)
Recommended Name: Bone morphogenetic protein 5 precursor  
Size: 454 amino acids; 51737 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Secreted
Secondary accessions: Q9H547 Q9NTM5

Explore the universe of human proteins at neXtProt for BMP5: NX_P22003

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P22003

    • BMP5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066551.1  
    ENSEMBL proteins: 
     ENSP00000359866   ENSP00000391818  

    Human Recombinant Protein Products: 
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    Novus Biologicals BMP5 Proteins
    Novus Biologicals BMP5 Lysates
    Sino Biological Recombinant Protein for BMP5
    ProSpec Recombinant Protein for BMP5
    Uscn Proteins for BMP5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region ----
    GO:0005615extracellular space ISS--
    GO:0031988membrane-bounded vesicle ISS--


    BMP5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BMP5

    Protein Domains /
    Families
    for BMP5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BMP5 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P22003

    ProtoNet protein and cluster: P22003

    3 Blocks protein families:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: BMP5_HUMAN, P22003
    Similarity: Belongs to the TGF-beta family


    Function
    for BMP5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BMP5_HUMAN, P22003
    Function: Induces cartilage and bone formation

         Genatlas biochemistry entry for BMP5:
    bone morphogenetic protein 5 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),mouse short-ear (se)
    homolog

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMP5 (see all 7)
    OriGene shRNA RFP: BMP5
    OriGene siRNA: BMP5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP5

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMP5 (see all 3)
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    Cell Line
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    LifeMap BioReagents: cell lines associated with BMP5: PureStem 7PEND24, NCr-fac & Meso-prx Progenitor,
    PureStem 7SMOO32, NCr-fac & Meso Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP5

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity NAS--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
    GO:0070700BMP receptor binding IPI7811286


    BMP5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for BMP5:
     Increased cell death HMECs cel 

    Animal Models:
         15/16 MGI mutant phenotypes (inferred from 21 alleles) (MGI details for Bmp5) (see all 16):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  immune system  limbs/digits/tail 
     liver/biliary system  mortality/aging  renal/urinary system  reproductive system  respiratory system 

    BMP5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BMP5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2PEDF Induced Signaling
    8/11 pathways (see all 11)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    3GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/71 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BMP5 (see all 71)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway


    2         Kegg Pathways  (Kegg details for BMP5):
        Hedgehog signaling pathway
    TGF-beta signaling pathway


    BMP5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BMP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for BMP5 (P220033 ENSP000003598664) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHRDL2Q6WN343, ENSP000002636714I2D: score=2 STRING: ENSP00000263671
    BMPR1AP368943, ENSP000002247644I2D: score=1 STRING: ENSP00000224764
    FSTP198833, ENSP000002567594I2D: score=1 STRING: ENSP00000256759
    NOGQ132533, ENSP000003281814I2D: score=1 STRING: ENSP00000328181
    AMHR2ENSP000002578634STRING: ENSP00000257863
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development NAS2263636
    GO:0001503ossification IEA--
    GO:0003323type B pancreatic cell development IDA11865031
    GO:0007389pattern specification process ----
    GO:0008285negative regulation of cell proliferation IDA19584291


    BMP5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BMP5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BMP5
    Search CenterWatch for drugs/clinical trials and news about BMP5 

    Transcripts
    for BMP5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BMP5 gene: 
    NM_021073.2  

    Unigene Cluster for BMP5:

    Bone morphogenetic protein 5
    Hs.296648  [show with all ESTs]
    Unigene Representative Sequence: NM_021073
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370830(uc003pcq.3 uc011dxf.2) ENST00000446683

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMP5 (see all 7)
    OriGene shRNA RFP: BMP5
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP5
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK291559.1 AK303576.1 BC027958.1 M60314.1 

    4 DOTS entries:

    DT.310188  DT.99973919  DT.92420579  DT.97840409 

    24/84 AceView cDNA sequences (see all 84):

    CK905008 AI004250 AU100077 NM_021073 AW316957 BI966131 AW275116 AL601116 
    CR605366 BE501543 M60314 AW089164 BQ218167 AL550385 BX378135 BM992429 
    AL540742 AL569760 BC027958 BX483417 AW089167 CD677200 AI160907 BQ025899 

    GeneLoc Exon Structure


    Expression
    for BMP5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BMP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGCTGCCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BMP5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordPreganglionic ColumnPreganglionic Motor NeuronsMotor Neurons
    BoneAutopod PerichondriumEndochondral PreosteoblastsBone
    BoneStylopod PerichondriumEndochondral PreosteoblastsBone
    BoneZeugopod PerichondriumEndochondral PreosteoblastsBone
    BrainChoroid PlexusChoroid Plexus Progenitor CellsChoroid Plexus
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    HeartMyocardiumCardiomyocytes Progenitor CellsMyocardium
    Lateral Plate MesodermCardiogenic MesodermPre-myocardial CellsMyocardium
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    HeartCardiac CrescentCardiac Crescent CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Cardiomyocyte-like progenitor cells (Derivation of cardio...)
    DKK1-induced cells (Derivation of cardio...)

    See BMP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BMP5

    SOURCE GeneReport for Unigene cluster: Hs.296648

    UniProtKB/Swiss-Prot: BMP5_HUMAN, P22003
    Tissue specificity: Expressed in the lung and liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including BMP5: 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for BMP5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for BMP5 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BMP51 bone morphogenetic protein 5 83.55(n)
    92.7(a)    		   396053  NM_205148.3  NP_990479.1 
    lizard
    (Anolis carolinensis)    		 Reptilia BMP56
    		 --
    		 89(a)
    		 1 ↔ 1
    		 GL343342.1(753567-844505)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc642302 similar to bone morphogenetic protein 5 77.06(n)   394026  BC054647.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta gbb3 TGFbeta receptor signaling pathway
    transforming more    		 34(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea dbl-11 , 3 TGF-beta-like growth factor3
    Protein DBL-11    		 34(a)3
    46.48(n)1
    36.18(a)1    		   V(6760886-6762540)3
    1790681  NM_072308.41  NP_504709.11 


    ENSEMBL Gene Tree for BMP5 (if available)
    TreeFam Gene Tree for BMP5 (if available) 

    Paralogs
    for BMP5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BMP5 gene
    GDF52  GDF32  GDF62  BMP8B2  BMP42  GDF72  GDF22  BMP22  
    BMP102  BMP32  BMP72  GDF102  GDF12  BMP8A2  BMP62  
    7 SIMAP similar genes for BMP5 using alignment to 2 protein entries:     BMP5_HUMAN (see all proteins):
    BMP3    BMPY    BMP6    BMP7    BMP8A    BMP8B
    BMP4

    BMP5 for paralogs           About GeneDecksing



    Genomic Variants
    for BMP5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2010 NCBI SNPs in BMP5 are shown (see all 2010)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs115377211,2
    		C,F,H,--55620017(+) ATTATG/ATAAAA 1 -- ds5001 ese321Minor allele frequency- A:0.21NA NS EA WA CSA 2483
    rs728688331,2
    		C,F,--55620102(+) TATTGT/CATAAT 1 -- ds50011Minor allele frequency- C:0.10NA 120
    rs1384961661,2
    		--55620164(+) ATATAC/TGTTTA 1 -- ds50010--------
    rs37569911,2
    		C,F,H,--55620218(-) ATTTTG/TACTCT 1 -- ds500110Minor allele frequency- T:0.08NA NS EA CSA 804
    rs37569901,2
    		C,F,H,--55620251(-) CAAACG/AGGGAA 1 -- ut31 ese323Minor allele frequency- A:0.16NA NS EA CSA WA 2900
    rs2008821861,2
    		--55620353(+) AGCGTA/CCTACC 2 G V mis10--------
    rs1815443651,2
    		--55620369(+) TCTATA/GTTTTT 2 H Y mis10--------
    rs37988491,2
    		C,F,H,--55620809(-) ACAGTC/TATTTC 1 -- int131Minor allele frequency- T:0.12EA NA NS WA CSA 4131
    rs1862243411,2
    		--55620926(+) AGCAAC/TAAATC 1 -- int10--------
    rs1472901351,2
    		--55621014(+) TCCAAA/TACTTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for BMP5 (55618443 - 55740375 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BMP5: --
    Human Gene Mutation Database (HGMD): BMP5

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BMP5
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP5

    Disorders / Diseases
    for BMP5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BMP5 for disorders           About GeneDecksing

    OMIM gene information: 112265    OMIM disorders: --

    20/26 diseases for BMP5 (see all 26):    About MalaCards
    meier-gorlin syndrome    glaucoma    malignant peripheral nerve sheath tumor    short stature
    squamous cell papilloma    microtia    nephrosclerosis    papilloma
    adrenocortical carcinoma    rheumatoid arthritis    multiple sclerosis    osteoarthritis
    colon carcinoma    arthritis    periodontitis    osteosarcoma
    prostate cancer    breast cancer    myeloma    carcinoma

    1 disease from the University of Copenhagen DISEASES database for BMP5:
    Squamous cell papilloma

    1 Novoseek disease relationship for BMP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis 37.5 2 20021689 (1), 17220169 (1)

    Genetic Association Database (GAD): BMP5
    Human Genome Epidemiology (HuGE) Navigator: BMP5 (4 documents)

    Export disorders for BMP5 gene to outside databases

    Publications
    for BMP5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BMP5 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with BMP5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. (PubMed id 11580864)1, 3, 9 Beck H.N....Lein P.J. (2001)
    2. A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. (PubMed id 1427904)1, 3, 9 Hahn G.V....Kaplan F.S. (1992)
    3. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. (PubMed id 2263636)1, 2, 9 Celeste A.J.... Wozney J.M. (1990)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Association of a functional microsatellite within int ron 1 of the BMP5 gene with susceptibility to osteoarthritis. (PubMed id 20021689)1, 9 Wilkins J.M....Loughlin J. (2009)
    7. Extreme context specificity in differential allelic expression. (PubMed id 17220169)1, 9 Wilkins J.M....Loughlin J. (2007)
    8. Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. (PubMed id 16542506)1, 9 Bramlage C.P....Burmester G.R. (2006)
    9. Bone morphogenetic proteins and growth and differentiation factors in the human cornea. (PubMed id 9950587)1, 9 You L....Volcker H.E. (1999)
    10. Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter. (PubMed id 8630036)1, 9 Sakaue M....Maeda S. (1996)

    External Searches for BMP5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BMP5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 653 HGNC: 1072 AceView: BMP5 Ensembl:ENSG00000112175 euGenes: HUgn653
    ECgene: BMP5 Kegg: 653 H-InvDB: BMP5

    Other Databases showing BMP5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BMP5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BMP5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP5 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_5

    Intellectual Property
    for BMP5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BMP5 gene:
    Search GeneIP for patents involving BMP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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     BMP5 Proteins, Antibodies, CLIAs, and ELISAs
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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