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BMP5 Gene

protein-coding   GIFtS: 66
GCID: GC06M055667

Bone Morphogenetic Protein 5

  See BMP5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bone Morphogenetic Protein 51 2
BMP-52 3
Bone Morphogenenic Protein-52

External Ids:    HGNC: 10721   Entrez Gene: 6532   Ensembl: ENSG000001121757   OMIM: 1122655   UniProtKB: P220033   

Export aliases for BMP5 gene to outside databases

Previous GC identifers: GC06M055622 GC06M055728 GC06M055455


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BMP5 Gene:
This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth
factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone
morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce
endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides,
cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within
the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene
is differentially regulated during the formation of various tumors. (provided by RefSeq, Jul 2008)

GeneCards Summary for BMP5 Gene:
BMP5 (bone morphogenetic protein 5) is a protein-coding gene. Diseases associated with BMP5 include squamous cell papilloma, and meier-gorlin syndrome. GO annotations related to this gene include BMP receptor binding and cytokine activity. An important paralog of this gene is GDF5.

UniProtKB/Swiss-Prot: BMP5_HUMAN, P22003
Function: Induces cartilage and bone formation

Gene Wiki entry for BMP5 (Bone morphogenetic protein 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BMP5 gene promoter:
         c-Fos   AML1a   SREBP-1c   Nkx2-2   Nkx2-5   SREBP-1b   SREBP-1a   HFH-1   c-Jun   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP5 promoter sequence
   Search Chromatin IP Primers for BMP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.1   HGNC cytogenetic band: 6p12.1

BMP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M055667:  view genomic region     (about GC identifiers)

Start:
55,618,443 bp from pter      End:
55,740,375 bp from pter
Size:
121,933 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BMP5_HUMAN, P22003 (See protein sequence)
Recommended Name: Bone morphogenetic protein 5 precursor  
Size: 454 amino acids; 51737 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Secondary accessions: Q9H547 Q9NTM5

Explore the universe of human proteins at neXtProt for BMP5: NX_P22003

Explore proteomics data for BMP5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn211, Asn327, Asn345, Asn395
  • Modification sites at PhosphoSitePlus

  • See BMP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066551.1  
    ENSEMBL proteins: 
     ENSP00000359866   ENSP00000391818  

    BMP5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BMP5

     
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    antibodies-online proteins for BMP5 (33 products) 

     
    antibodies-online peptides for BMP5

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    antibodies-online antibodies for BMP5 (75 products) 

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    antibodies-online kits for BMP5 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    BMP: Bone morphogenetic proteins

    4 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P22003

    ProtoNet protein and cluster: P22003

    3 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: BMP5_HUMAN, P22003
    Similarity: Belongs to the TGF-beta family


    Find genes that share domains with BMP5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP5_HUMAN, P22003
    Function: Induces cartilage and bone formation

         Genatlas biochemistry entry for BMP5:
    bone morphogenetic protein 5 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),mouse short-ear
    (se) homolog

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
    GO:0070700BMP receptor binding IPI7811286
         
    Find genes that share ontologies with BMP5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BMP5:
     Increased cell death HMECs cel 

         Selected MGI mutant phenotypes (inferred from 21 alleles(MGI details for Bmp5) (see all 16):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  immune system  limbs/digits/tail 
     liver/biliary system  mortality/aging  renal/urinary system  reproductive system  respiratory system 

    Find genes that share phenotypes with BMP5           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for BMP5

    miRNA
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    Gene Editing
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    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BMP5_HUMAN, P22003: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region ----
    GO:0005615extracellular space ISS--
    GO:0031988membrane-bounded vesicle ISS--

    Find genes that share ontologies with BMP5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BMP5 About   (see all 20)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58


    Find genes that share SuperPaths with BMP5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BMP5 (see all 71)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    1 Sino Biological Pathway for BMP5
        TGF-beta Signaling Pathway


    2 Kegg Pathways  (Kegg details for BMP5):
        TGF-beta signaling pathway
    Hippo signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMP5: 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BMP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for BMP5 (P220033 ENSP000003598664) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHRDL2Q6WN343, ENSP000002636714I2D: score=2 STRING: ENSP00000263671
    FSTP198833, ENSP000002567594I2D: score=1 STRING: ENSP00000256759
    NOGQ132533, ENSP000003281814I2D: score=1 STRING: ENSP00000328181
    BMPR1AP368943I2D: score=1 
    AMHR2ENSP000002578634STRING: ENSP00000257863
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development NAS2263636
    GO:0001503ossification IEA--
    GO:0003323type B pancreatic cell development IDA11865031
    GO:0007389pattern specification process IEA--
    GO:0008285negative regulation of cell proliferation IDA19584291

    Find genes that share ontologies with BMP5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BMP5

    1 PharmGKB related drug/compound annotation for BMP5 gene    About this table
    Drug/compound PharmGKB Annotation
    escitalopramCA  



    Find genes that share compounds with BMP5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BMP5 gene: 
    NM_021073.2  

    Unigene Cluster for BMP5:

    Bone morphogenetic protein 5
    Hs.296648  [show with all ESTs]
    Unigene Representative Sequence: NM_021073
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370830(uc003pcq.3 uc011dxf.2) ENST00000446683
    miRNA
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    Additional mRNA sequence: 

    AK291559.1 AK303576.1 BC027958.1 M60314.1 

    4 DOTS entries:

    DT.310188  DT.99973919  DT.92420579  DT.97840409 

    Selected AceView cDNA sequences (see all 84):

    AW089164 CD677200 AI004250 CR605366 BX483417 BI966131 BM992429 AW316957 
    AL601116 BE501543 AL540742 BC027958 AL550385 AW089167 AU100077 AL569760 
    AW275116 CK905008 M60314 BX378135 NM_021073 BQ218167 AU139316 AL691780 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BMP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTGCCAC
    BMP5 Expression
    About this image


    BMP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Cardiac Crescent Cells Cardiac Crescent
             Cardiomyocyte-like progenitor cells
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Neurons
             Preganglionic Motor Neurons Preganglionic Column
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             Early Ameloblasts Dental Enamel
     
     Spinal Cord (Nervous System)
             Preganglionic Motor Neurons Preganglionic Column
    BMP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BMP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.296648

    UniProtKB/Swiss-Prot: BMP5_HUMAN, P22003
    Tissue specificity: Expressed in the lung and liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMP5: 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat BMP5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BMP5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp51 , 5 bone morphogenetic protein 51, 5 89.43(n)1
    93.17(a)1
      9 (42.34 cM)5
    121601  NM_007555.31  NP_031581.21 
     757753645 
    chicken
    (Gallus gallus)
    Aves BMP51 bone morphogenetic protein 5 83.55(n)
    92.7(a)
      396053  NM_205148.3  NP_990479.1 
    lizard
    (Anolis carolinensis)
    Reptilia BMP56
    bone morphogenetic protein 5
    89(a)
    1 ↔ 1
    GL343342.1(751396-844505)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bmp51 bone morphogenetic protein 5 75.52(n)
    82.59(a)
      100494976  XM_004914496.1  XP_004914553.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc642302 similar to bone morphogenetic protein 5 77.06(n)   394026  BC054647.1 


    ENSEMBL Gene Tree for BMP5 (if available)
    TreeFam Gene Tree for BMP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BMP5 gene
    GDF52  GDF32  BMP8B2  GDF62  BMP42  GDF72  GDF22  BMP22  
    BMP102  BMP72  GDF12  BMP8A2  BMP62  
    7 SIMAP similar genes for BMP5 using alignment to 3 protein entries:     BMP5_HUMAN (see all proteins):
    BMP3    BMPY    BMP6    BMP7    BMP8A    BMP8B
    BMP4

    Find genes that share paralogs with BMP5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BMP5 (see all 2330)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115377211,2
    C,F,H--55620017(+) ATTATG/ATAAAA 1 -- ds5001 ese321Minor allele frequency- A:0.21NA NS EA WA CSA 2483
    rs728688331,2
    C,F--55620102(+) TATTGT/CATAAT 1 -- ds50011Minor allele frequency- C:0.10NA 120
    rs1384961661,2
    --55620164(+) ATATAC/TGTTTA 1 -- ds50010--------
    rs37569911,2
    C,F,H--55620218(-) ATTTTG/TACTCT 1 -- ds500110Minor allele frequency- T:0.08NA NS EA CSA 804
    rs37569901,2
    C,F,H--55620251(-) CAAACG/AGGGAA 1 -- ut31 ese323Minor allele frequency- A:0.16NA NS EA CSA WA 2900
    rs2008821861,2
    --55620353(+) AGCGTA/CCTACC 2 G V mis10--------
    rs1815443651,2
    --55620369(+) TCTATA/GTTTTT 2 H Y mis10--------
    rs37988491,2
    C,F,H--55620809(-) ACAGTC/TATTTC 1 -- int131Minor allele frequency- T:0.12EA NA NS WA CSA 4131
    rs1862243411,2
    --55620926(+) AGCAAC/TAAATC 1 -- int10--------
    rs1472901351,2
    --55621014(+) TCCAAA/TACTTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for BMP5 (55618443 - 55740375 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BMP5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665663CNV Deletion23128226
    nsv885910CNV Loss21882294
    dgv6850n71CNV Loss21882294
    nsv885909CNV Loss21882294

    Human Gene Mutation Database (HGMD): BMP5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BMP5
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 112265    OMIM disorders: --

    3 diseases for BMP5:    
    About MalaCards
    squamous cell papilloma    meier-gorlin syndrome    microtia

    1 disease from the University of Copenhagen DISEASES database for BMP5:
    Squamous cell papilloma

    Find genes that share disorders with BMP5           About GenesLikeMe

    1 Novoseek inferred disease relationship for BMP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis 37.5 2 20021689 (1), 17220169 (1)

    Genetic Association Database (GAD): BMP5
    Human Genome Epidemiology (HuGE) Navigator: BMP5 (4 documents)

    Export disorders for BMP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BMP5 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with BMP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. (PubMed id 11580864)1, 3, 9 Beck H.N....Lein P.J. (BMC Neurosci 2001)
    2. Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis. (PubMed id 20021689)1, 4, 9 Wilkins J.M....Loughlin J. (BMC Med. Genet. 2009)
    3. A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. (PubMed id 1427904)1, 3, 9 Hahn G.V....Kaplan F.S. (Genomics 1992)
    4. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. (PubMed id 2263636)1, 2, 9 Celeste A.J.... Wozney J.M. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Environmental and genetic factors associated with congenital microtia: a case-control study in Jiangsu, China, 2004 to 2007. (PubMed id 19935299)1, 4 Zhang Q.G....Shen H. (Plast. Reconstr. Surg. 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    10. Extreme context specificity in differential allelic expression. (PubMed id 17220169)1, 9 Wilkins J.M....Loughlin J. (Hum. Mol. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 653 HGNC: 1072 AceView: BMP5 Ensembl:ENSG00000112175 euGenes: HUgn653
    ECgene: BMP5 Kegg: 653 H-InvDB: BMP5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BMP5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP5 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_5

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BMP5 gene:
    Search GeneIP for patents involving BMP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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