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Aliases for BMP5 Gene

Aliases for BMP5 Gene

  • Bone Morphogenetic Protein 5 2 3
  • BMP-5 3 4
  • Bone Morphogenenic Protein-5 3

External Ids for BMP5 Gene

Summaries for BMP5 Gene

Entrez Gene Summary for BMP5 Gene

  • This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for BMP5 Gene

BMP5 (Bone Morphogenetic Protein 5) is a Protein Coding gene. Diseases associated with BMP5 include squamous cell papilloma and microtia. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and BMP receptor binding. An important paralog of this gene is BMP2.

UniProtKB/Swiss-Prot for BMP5 Gene

  • Induces cartilage and bone formation

Gene Wiki entry for BMP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP5 Gene

Genomics for BMP5 Gene

Genomic Location for BMP5 Gene

Start:
55,753,645 bp from pter
End:
55,875,590 bp from pter
Size:
121,946 bases
Orientation:
Minus strand

Genomic View for BMP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP5 Gene

Regulatory Elements for BMP5 Gene

Proteins for BMP5 Gene

  • Protein details for BMP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22003-BMP5_HUMAN
    Recommended name:
    Bone morphogenetic protein 5
    Protein Accession:
    P22003
    Secondary Accessions:
    • B4E0Y4
    • Q9H547
    • Q9NTM5

    Protein attributes for BMP5 Gene

    Size:
    454 amino acids
    Molecular mass:
    51737 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for BMP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BMP5 Gene

Proteomics data for BMP5 Gene at MOPED

Post-translational modifications for BMP5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn211, Asn327, Asn345, and Asn395

Other Protein References for BMP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BMP5 Gene

Domains for BMP5 Gene

Gene Families for BMP5 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • BMP :Bone morphogenetic proteins

UniProtKB/Swiss-Prot:

BMP5_HUMAN
Family:
  • Belongs to the TGF-beta family.:
    • P22003
genes like me logo Genes that share domains with BMP5: view

Function for BMP5 Gene

Molecular function for BMP5 Gene

GENATLAS Biochemistry: bone morphogenetic protein 5 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),mouse short-ear (se) homolog
UniProtKB/Swiss-Prot Function: Induces cartilage and bone formation

Gene Ontology (GO) - Molecular Function for BMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005515 protein binding --
GO:0008083 growth factor activity IEA --
GO:0070700 BMP receptor binding IDA 7811286
genes like me logo Genes that share ontologies with BMP5: view
genes like me logo Genes that share phenotypes with BMP5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BMP5 Gene

Localization for BMP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BMP5 Gene COMPARTMENTS Subcellular localization image for BMP5 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005615 extracellular space ISS --
GO:0031988 membrane-bounded vesicle ISS --
genes like me logo Genes that share ontologies with BMP5: view

Pathways for BMP5 Gene

genes like me logo Genes that share pathways with BMP5: view

Pathways by source for BMP5 Gene

Gene Ontology (GO) - Biological Process for BMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development NAS 2263636
GO:0001503 ossification IEA --
GO:0003323 type B pancreatic cell development IDA 11865031
GO:0007389 pattern specification process IEA --
GO:0008285 negative regulation of cell proliferation IDA 19584291
genes like me logo Genes that share ontologies with BMP5: view

Compounds for BMP5 Gene

(1) PharmGKB related drug/compound annotations for BMP5 Gene

Drug/compound Annotation
escitalopram CA
genes like me logo Genes that share compounds with BMP5: view

Transcripts for BMP5 Gene

mRNA/cDNA for BMP5 Gene

Unigene Clusters for BMP5 Gene

Bone morphogenetic protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BMP5 Gene

No ASD Table

Relevant External Links for BMP5 Gene

GeneLoc Exon Structure for
BMP5
ECgene alternative splicing isoforms for
BMP5

Expression for BMP5 Gene

mRNA expression in normal human tissues for BMP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BMP5 Gene

This gene is overexpressed in Bladder (8.3), Lung (7.4), and Prostate (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BMP5 Gene

SOURCE GeneReport for Unigene cluster for BMP5 Gene Hs.296648

mRNA Expression by UniProt/SwissProt for BMP5 Gene

P22003-BMP5_HUMAN
Tissue specificity: Expressed in the lung and liver
genes like me logo Genes that share expressions with BMP5: view

Orthologs for BMP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for BMP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BMP5 36
  • 99.85 (n)
  • 100 (a)
BMP5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BMP5 36
  • 90.9 (n)
  • 95.37 (a)
BMP5 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BMP5 36
  • 94.57 (n)
  • 98.24 (a)
BMP5 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bmp5 36
  • 89.43 (n)
  • 93.17 (a)
Bmp5 16
Bmp5 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BMP5 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BMP5 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bmp5 36
  • 89.28 (n)
  • 93.61 (a)
chicken
(Gallus gallus)
Aves BMP5 36
  • 83.55 (n)
  • 92.7 (a)
BMP5 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BMP5 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp5 36
  • 75.52 (n)
  • 82.59 (a)
zebrafish
(Danio rerio)
Actinopterygii bmp5 36
  • 70.29 (n)
  • 78.23 (a)
bmp5 37
  • 73 (a)
OneToOne
zgc64230 36
fruit fly
(Drosophila melanogaster)
Insecta scw 38
  • 28 (a)
gbb 38
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea dbl-1 38
  • 34 (a)
Species with no ortholog for BMP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP5 Gene

ENSEMBL:
Gene Tree for BMP5 (if available)
TreeFam:
Gene Tree for BMP5 (if available)

Paralogs for BMP5 Gene

Paralogs for BMP5 Gene

Selected SIMAP similar genes for BMP5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BMP5: view

Variants for BMP5 Gene

Sequence variations from dbSNP and Humsavar for BMP5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs228136 -- 55,761,729(+) tcact(C/G/T)tgttc intron-variant
rs228137 -- 55,762,301(+) GTTTA(A/G)TTACT intron-variant
rs228138 -- 55,762,910(+) CAATA(C/T)GTAAA intron-variant
rs228139 -- 55,763,485(+) TAAAT(G/T)TTGTA intron-variant
rs228140 -- 55,763,546(+) TAAGC(C/T)GTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BMP5 Gene

Variant ID Type Subtype PubMed ID
dgv6850n71 CNV Loss 21882294
nsv885909 CNV Loss 21882294
nsv885910 CNV Loss 21882294
esv2665663 CNV Deletion 23128226

Relevant External Links for BMP5 Gene

HapMap Linkage Disequilibrium report
BMP5
Human Gene Mutation Database (HGMD)
BMP5

Disorders for BMP5 Gene

(1) University of Copenhagen DISEASES for BMP5 Gene

(1) Novoseek inferred disease relationships for BMP5 Gene

Disease -log(P) Hits PubMed IDs
osteoarthritis 37.5 2

Relevant External Links for BMP5

Genetic Association Database (GAD)
BMP5
Human Genome Epidemiology (HuGE) Navigator
BMP5
genes like me logo Genes that share disorders with BMP5: view

No data available for UniProtKB/Swiss-Prot for BMP5 Gene

Publications for BMP5 Gene

  1. A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7. (PMID: 1427904) Hahn G.V. … Kaplan F.S. (Genomics 1992) 2 3 23
  2. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. (PMID: 2263636) Celeste A.J. … Wozney J.M. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 23
  3. Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis. (PMID: 20021689) Wilkins J.M. … Loughlin J. (BMC Med. Genet. 2009) 3 23 49
  4. Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons. (PMID: 11580864) Beck H.N. … Lein P.J. (BMC Neurosci 2001) 2 3 23
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for BMP5 Gene

Sources for BMP5 Gene

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