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BMP4 Gene

protein-coding GIFtS: 71

GC14M053486

bone morphogenetic protein 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: BMP2B)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BMP-2B ^³
BMP-4 ^³
BMP2B ^², ³, ⁵
BMP2B1 ^², ⁵
DVR4 ^³
MCOPS6 ^², ⁵
OFC11 ^², ⁵
ZYME ^²

Descriptions
bone morphogenetic protein 2B ^²
bone morphogenetic protein 4 ^²

External Ids
HGNC: 1071¹
Entrez Gene: 652²
UniProtKB: P12644³
Ensembl: ENSG00000125378⁷

Search outside databases for aliases for BMP4 gene

Previous GC identifers: GC14M051739 GC14M048212 GC14M052406

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BMP4:

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part

of the transforming growth factor-beta superfamily. The superfamily includes large families of

growth and differentiation factors. Bone morphogenetic proteins were originally identified by an

ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an

extraskeletal site. This particular family member plays an important role in the onset of

endochondral bone formation in humans, and a reduction in expression has been associated with a

variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.

Alternative splicing in the 5' untranslated region of this gene has been described and three

variants are described, all encoding an identical protein. [provided by RefSeq]

UniProtKB/Swiss-Prot: BMP4_HUMAN, P12644

Function: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development,

limb formation and fracture repair

Gene Wiki entry for BMP4 (Bone_morphogenetic_protein_4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BMP4 gene

Entrez Gene cytogenetic band: 14q22-q23 Ensembl cytogenetic band: 14q22.2 HGNC cytogenetic band: 14q22-q23

BMP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M053486: (about GC identifiers)

Start:	53,486,204 bp from pter
End:	53,493,304 bp from pter
Size:	7,101 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BMP4_HUMAN, P12644 (See protein sequence)

Recommended Name: Bone morphogenetic protein 4 precursor

Size: 408 amino acids; 46555 Da

Subunit: Homodimer; disulfide-linked (By similarity). Interacts with GREM2 (By similarity) and

SOSTDC1. Part of a complex consisting of TWSG1 and CHRD (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: Q9UM80

REFSEQ proteins (3 alternative transcripts):

NP_001193.2 NP_570911.2 NP_570912.2

ENSEMBL proteins:

ENSP00000245451 ENSP00000378964

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for BMP4
	R&D Systems Recombinant & Natural Proteins for BMP4 (BMP-4, BMP-4/BMP-7 Heterodimer)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BMP4, BMP2+4)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IEA	--

About this table

Antibodies for BMP4:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of BMP4
	Sigma-Aldrich Antibodies for BMP4
	R&D Systems Antibodies for BMP4 (BMP-4)
	Antibodies from Abcam (BMP4, BMP2+4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BMP4)
	Novus Biologicals Antibodies for BMP4

Assays for BMP4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems Flow Cytometry Kits for BMP4 (BMP-4) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P12644

ProtoNet protein and cluster: P12644

2 Blocks protein families:

IPB001111 Transforming growth factor beta (TGFb)

IPB001839 Transforming growth factor beta (TGFb)

UniProtKB/Swiss-Prot: BMP4_HUMAN, P12644

Similarity: Belongs to the TGF-beta family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BMP4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_130850

Applied Biosystems Silencer® siRNAs for BMP4

Sigma-Aldrich siRNA and siRNA Panels for BMP4

Sigma-Aldrich shRNA Panels and shRNA for BMP4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BMP4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001202
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001202
untagged cDNA clones in CMV expression vector (see all 3): NM_001202

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001202

UniProtKB/Swiss-Prot: BMP4_HUMAN, P12644

Function: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development,

limb formation and fracture repair

Genatlas biochemistry entry for BMP4:

bone morphogenetic protein 4 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB

superfamily),BMP4 expression under MSX2 control,inducing ventralizing signals inhibited by

noggin,also inducing apoptosis and chondrogenesis in the chick limb bud,inhibited by

FGF4,regulating myogenesis through dosage-dependent PAX3 expression in pre-myogenic cells

15/24 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Bmp4) (see all 24 ):

	behavior/neurological	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal	limbs/digits/tail	liver/biliary system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	TAS	9804553
GO:0005125	cytokine activity	IDA	14749725
GO:0005515	protein binding	IPI	18775317
GO:0008083	growth factor activity	IEA	--
GO:0008201	heparin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/10 Sigma-Aldrich "Your Favorite Gene" Pathways for BMP4 (Your Favorite Gene powered by Ingenuity) (see all 10 )

Basal Cell Carcinoma Signaling
Axonal Guidance Signaling
NF-&kappa
Factors Promoting Cardiogenesis in Vertebrates
TGF-&beta

GeneDecks BMP4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BMP4

5/162 Interacting proteins for BMP4 (ENSP00000245451³ P12644^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 162 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
chrd chrd (xeno)	Q91713¹	EBI-1998134, EBI-1997746
ZFYVE9	O95405²	MINT-62054
BMPR1A	ENSP00000361107³	STRING (score=.999)
BMPR1B	ENSP00000264568³	STRING (score=.999)
BMPR2	ENSP00000363708³	STRING (score=.999)

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5/29 Gene Ontology (GO) biological process terms (links to tree view) (see all 29 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001658	ureteric bud branching	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007281	germ cell development	IEA	--
GO:0007500	mesodermal cell fate determination	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BMP4
10/25 Novoseek chemical compound relationships for BMP4 gene (see all 25 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclopamine	52.50	1	11487541 (1)
tgf beta1	41.75	11	18172096 (4), 17617449 (1), 18434375 (1), 9739114 (1) (see all 5)
threonine	31.04	5	7673243 (1), 9577408 (1), 15621726 (1), 7811286 (1) (see all 5)
ribonucleic acid	15.20	5	12616078 (1), 12672843 (1), 9577408 (1)
heparan sulfate	9.39	11	18385288 (2), 17055473 (2), 17944754 (1)
matrigel	1.53	2	18535293 (1), 17526776 (1)
nitric oxide	0.44	5	15060574 (4)
forskolin	0.00	7	10999829 (4), 17272757 (2)
deoxyribonucleic acid	0.00	1	9577410 (1)
bromodeoxyuridine	0.00	2	16458882 (1), 8682183 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BMP4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_130850

Sigma-Aldrich siRNA and siRNA Panels for BMP4

Sigma-Aldrich shRNA Panels and shRNA for BMP4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001202 NM_130850 NM_130851

REFSEQ mRNAs for BMP4 gene (3 alternative transcripts):

NM_001202.3 NM_130850.2 NM_130851.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001202 NM_130850 NM_130851

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001202
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001202
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001202

Additional cDNA sequence:

BC020546.2 BX161385.1 BX161438.1 CR595138.1 CR603423.1 CR615807.1 M22490.1

11 DOTS entries:

DT.444673 DT.91744114 DT.100804406 DT.100787271 DT.91744115 DT.100696704 DT.75188866 DT.86851128

DT.95275953 DT.95303693 DT.100787269

24/158 AceView cDNA sequences (see all 158 ):

BQ573792 BE512742 BM791751 BE877424 BU190376 BU628523 BM698963 BM998225

BE304524 BE867398 CR615807 CA428190 BM557669 BX161438 BX161385 BM687933

CR595138 CB159290 BM561296 CR603423 M22490 T54134 BQ641785 BG328313

highest scoring ESTs for BMP4:

M22490 AA584413 BC020546 BE512742 BE617281 BE740078 BE869477 BF982469 BF983498 BF983505

Unigene Cluster for BMP4:

Bone morphogenetic protein 4

Hs.68879 [show with all ESTs]

Unigene Representative Sequence: NM_001202

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for BMP4 (see all 7 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	·	4e	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f
SP1:									-		-				-		-
SP2:									-		-				-
SP3:											-				-
SP4:			-		-		-		-		-				-
SP5:															-		-

About this scheme

ECgene alternative splicing isoforms for BMP4

2 Ensembl transcripts including schematic representations:

ENST00000245451 ENST00000395600

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BMP4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BMP4

¹ / ² / ³

4 probe-sets matching BMP4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40333_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.98	U43842	0.20	1.00	0.72	1
1114_at²^{, 3}	U95-A	1	1.00	1.00	0.90	1.02	M22490	1.00	1.00	1.00	1
211518_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D30751	0.40	1.00	0.76	1
211518_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BMP4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGTACCTGG

SOURCE GeneReport for Unigene cluster: Hs.68879
Expression variation in blood from EXPOLDB for BMP4
UniProtKB/Swiss-Prot: BMP4_HUMAN, P12644
Tissue specificity: Expressed in the lung and lower levels seen in the kidney. Present also in
normal and neoplastic prostate tissues, and prostate cancer cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BMP4 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BMP4¹	--	bone morphogenetic protein 4	94.12(n) 96.57(a)	490695 XM_859096.1 XP_864189.1
chimpanzee (Pan troglodytes)	BMP4¹	--	bone morphogenetic protein 4	97.62(n) 96.56(a)	452912 XM_509954.2 XP_509954.2
cow (Bos taurus)	BMP4¹	--	bone morphogenetic protein 4	95.18(n) 98.28(a)	407216 NM_001045877.1 NP_001039342.1
rat (Rattus norvegicus)	Bmp4¹	--	bone morphogenetic protein 4	91.89(n) 96.81(a)	25296 NM_012827.1 NP_036959.1
mouse (Mus musculus)	Bmp4^{1, 5}	14 (15.00 cM)⁵	bone morphogenetic protein 4^{1, 5}	92.55(n)¹ 97.54(a)¹	12159¹ NM_007554.2¹ NP_031580.2¹ AK136527⁵ AK145359⁵ (see all 13)

About this table Species with no ortholog for BMP4

ENSEMBL Gene Tree for BMP4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BMP4 gene

BMP10² GDF2² BMP2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/53 NCBI SNPs in BMP4 are shown (see all 53 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 39)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs17563^1,2	A,C,F,H,O	53487272(-)	`CGAGGT/CGATCT`	3	A/V	mis¹		17		MN CSAM EA EU WA NA	1590
	rs2761887^1,2	A,C,F,H	53494802(+)	`GCCATA/CTTTTC`	2	--	ng3¹		8		EU EA WA	832
	rs762642^1,2	A,C,F,H	53492803(-)	`GGAGAT/GTCTCA`	3	--	ng3¹ int¹		5		MN EU EA WA	604
--	rs762643^1,2	A,C,F	53492517(-)	`CCGCTC/ACGGAG`	3	--	int¹ ng3¹		1		MN	184
--	rs2032423^1,2	A,C	53494897(-)	`ctgagA/Gctcat`	2	--	ng3¹		0	--	--	--	--
	rs2738265^1,2	A,C	53492149(-)	`TTAGAC/GGCCTC`	3	--	int¹ ng3¹		0	--	--	--	--
	rs2855530^1,2	A,C	53491667(-)	`CCTCGC/GCGGGC`	3	--	int¹ ng3¹		0	--	--	--	--
--	rs2855527^1,2	C	53494419(-)	`GTCCTG/TCCTTT`	2	--	ng3¹		0	--	--	--	--
	rs3759652^1,2	H	53494543(+)	`GAGTGC/GTGGAA`	2	--	ng3¹		4		EU EA WA	416
	rs2071047^1,2	A,C,F,H	53488161(-)	`GCCGCT/CGAACT`	3	--	int¹		9		EA EU WA	2328

About this table

HapMap Linkage Disequilibrium images for BMP4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 112262 disorders: 607932 600625

UniProtKB/Swiss-Prot: BMP4_HUMAN, P12644

Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6) [MIM:607932];

also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit

developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation,

ranging from small size of a single eye to complete bilateral absence of ocular tissues

(anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes

that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia/anophthalmia

associated with facial, genital, skeletal, neurologic and endocrine anomalies

10/54 Novoseek disease relationships for BMP4 gene (see all 54 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fibrodysplasia ossificans progressiva	85.50	40	12672843 (6), 8678932 (4), 9577410 (3), 12579020 (3) (see all 17)
ossification heterotopic	63.09	8	14711949 (2), 17345627 (2), 11521229 (1)
carcinoma embryonal	47.56	11	8903360 (2), 17941089 (1), 11478839 (1), 10578180 (1) (see all 8)
polydactyly, postaxial	39.97	3	15581864 (1), 10964473 (1)
genetic disorder	35.17	6	17345627 (1), 11521229 (1), 10457277 (1)
congenital malformation	33.90	3	11722794 (2), 16414041 (1)
cleft palate	30.54	3	12163415 (2), 18771417 (1)
osteosarcoma	30.19	4	7579580 (1), 11986346 (1), 12881039 (1), 9874511 (1)
pilomatricoma	29.96	2	15701082 (1)
polydactyly	26.20	5	15581864 (1), 18925664 (1), 18252212 (1)

About this table

Human Gene Mutation Database: BMP4
Genetic Association Database: BMP4
Human Genome Epidemiology Navigator: BMP4 (11 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/605 PubMed articles for BMP4 gene (see all 605 ):

Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library. (PubMed id 7579580)^{1, 2, 3, 4} Oida S....Sasaki S. (1995)
Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs). (PubMed id 12404109)^{3, 4, 6} Felder B....Koch M.C. (2002)
Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways. (PubMed id 18252212)^{1, 3, 4} Bakrania P.... Ragge N.K. (2008)
The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation. (PubMed id 9701626)^{1, 3, 4} Shore E.M.... Kaplan F.S. (1998)
SIX2 and BMP4 mutations associate with anomalous kidney development. (PubMed id 18305125)^{3, 4} Weber S.... Burdine R.D. (2008)
USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. (PubMed id 15020244)^{3, 4} Yanagita M.... Sakurai T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Fine mapping of the human bone morphogenetic protein-4 gene (BMP4) to chromosome 14q22-q23 by in situ hybridization. (PubMed id 7558046)^{2, 3} van den Wijngaard A....Olijve W. (1995)
Novel regulators of bone formation: molecular clones and activities. (PubMed id 3201241)^{3, 4} Wozney J.M.... Wang E.A. (1988)
Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. (PubMed id 17472960)^{1, 3} Xia Y....Lin H.Y. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 652	HGNC: 1071	AceView: BMP4	Ensembl:ENSG00000125378	euGenes: HUgn652
ECgene: BMP4	H-InvDB: BMP4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BMP4	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_4

Licensable Technologies for BMP4
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for BMP4 gene:

Tufts University:

Use of miRNAs to selectively modulate TGF-?/BMP signaling to treat TGF-?/BMP mediated disorders

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BMP4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BMP4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BMP4		Antibodies for BMP4
	Explore super-pooled esiRNAs		Proteins for BMP4
	Lentivirus-delivered shRNAs for BMP4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (BMP4)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (BMP4, BMP2+4)
	Antibodies (BMP4, BMP2+4)

Search OriGene for BMP4

Search Tocris compounds for BMP4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BMP4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
BMP4 Gene at Home site.
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BMP4 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for BMP4

Summaries
for BMP4

Genomic Location
for BMP4

Proteins
for BMP4

Protein Domains/
Families
for BMP4

Gene Function
for BMP4

Pathways & Interactions
for BMP4

Drugs & Compounds
for BMP4

Transcripts
for BMP4

Expression
for BMP4

Orthologs
for BMP4

Paralogs
for BMP4

SNPs/Variants
for BMP4

Disorders & Mutations
for BMP4

Medical News
for BMP4

Publications
for BMP4

Search for BMP4

Genome Databases showing BMP4

Other Databases showing BMP4

Specialized Databases showing BMP4

Licensable Technologies
for BMP4

Services
for BMP4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BMP4 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor BMP4

Summariesfor BMP4

Genomic Locationfor BMP4

Proteinsfor BMP4

Protein Domains/Familiesfor BMP4

Gene Functionfor BMP4

Pathways & Interactionsfor BMP4

Drugs & Compoundsfor BMP4

Transcriptsfor BMP4

Expression for BMP4

Orthologsfor BMP4

Paralogsfor BMP4

SNPs/Variantsfor BMP4

Disorders & Mutationsfor BMP4

Medical Newsfor BMP4

Publicationsfor BMP4

Search for BMP4

Genome Databases showing BMP4

Other Databases showing BMP4

Specialized Databases showing BMP4

Licensable Technologiesfor BMP4

Servicesfor BMP4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BMP4

Summaries
for BMP4

Genomic Location
for BMP4

Proteins
for BMP4

Protein Domains/
Families
for BMP4

Gene Function
for BMP4

Pathways & Interactions
for BMP4

Drugs & Compounds
for BMP4

Transcripts
for BMP4

Expression
for BMP4

Orthologs
for BMP4

Paralogs
for BMP4

SNPs/Variants
for BMP4

Disorders & Mutations
for BMP4

Medical News
for BMP4

Publications
for BMP4

Licensable Technologies
for BMP4

Services
for BMP4