Aliases for BMP3 Gene
External Ids for BMP3 Gene
Previous GeneCards Identifiers for BMP3 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. [provided by RefSeq, Jul 2016]
GeneCards Summary for BMP3 Gene
BMP3 (Bone Morphogenetic Protein 3) is a Protein Coding gene. Diseases associated with BMP3 include Dentine Erosion and Chromosome 4Q21 Deletion Syndrome. Among its related pathways are DREAM Repression and Dynorphin Expression and Activation of cAMP-Dependent PKA. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is GDF10.
UniProtKB/Swiss-Prot for BMP3 Gene
Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.