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BMP3 Gene

protein-coding   GIFtS: 60

GC04P082247
bone morphogenetic protein 3
(Previous name: bone morphogenetic protein 3 (osteogenic) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
BMP-3 3
BMP-3A 2, 3
Osteogenin 3
osteogenin 2
Descriptions
bone morphogenetic protein 3 2
bone morphogenetic protein 3 (osteogenic) 1, 2
bone morphogenetic protein-3 2
External Ids
HGNC: 10701
Entrez Gene: 6512
UniProtKB: P126453
Ensembl: ENSG000001527857
Search outside databases for aliases for BMP3 gene

Previous GC identifers: GC04P081849 GC04P082410 GC04P082309

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for BMP3:
BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein,
also known as osteogenin, induces bone formation. [provided by RefSeq]

UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645
Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to
induce osteoprogenitor differentitation and ossification

Gene Wiki entry for BMP3 (Bone_morphogenetic_protein_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BMP3 gene  

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21

BMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P082247:     (about GC identifiers)

Start:
82,171,143 bp from pter
End:
82,197,709 bp from pter
Size:
26,567 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000004.10  NT_016354.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645 (See protein sequence)
Recommended Name: Bone morphogenetic protein 3 precursor  
Size: 472 amino acids; 53372 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Secreted
PDB structures from and Proteopedia :
2QCQ (3D)    
Secondary accessions: Q4VAS5

REFSEQ proteins: NP_001192.2  

ENSEMBL proteins: 
ENSP00000378948 ENSP00000282701 


Human Recombinant Proteins 
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Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
R&D Systems Recombinant & Natural Proteins for BMP3 (BMP-3)
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (BMP3)
Human Recombinant Proteins from Abnova (BMP3)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005615 extracellular space IEA--
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Antibodies for BMP3: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for BMP3
R&D Systems Antibodies for BMP3 (BMP-3)
Antibodies from Abcam (BMP3), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Novus Biologicals Antibodies for BMP3

Assays for BMP3: 
Browse Invitrogen for biochemical assays
Millipore Kits and Assays for the Analysis of BMP3
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

4 InterPro domains/families:
 IPR015615 TGFbeta
 IPR017197 BMP3/GDF10
 IPR001839 TGFb
 IPR017948 TGFb_CS


   GeneDecks  BMP3 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P12645

ProtoNet protein and cluster: P12645

2 Blocks protein families:
IPB001839 Transforming growth factor beta (TGFb)
IPB002400 Growth factor cystine knot superfamily signature


UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645
Similarity: Belongs to the TGF-beta family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (BMP3)
Millipore RNAi Products for the Analysis of BMP3 Gene knock-down
Abnova Chimera RNAi Products for Gene knock-down (BMP3)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001201

              Applied Biosystems Silencer® siRNAs for BMP3

              Sigma-Aldrich siRNA and siRNA Panels for BMP3  
                     Sigma-Aldrich shRNA for BMP3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for BMP3
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001201
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001201
                                 untagged cDNA clone in CMV expression vector: NM_001201 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001201

UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645
Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to
induce osteoprogenitor differentitation and ossification
Induction: Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and
chondroblasts

Genatlas biochemistry entry for BMP3:
bone morphogenetic protein 3 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily)

1 MGI mutant phenotype (inferred from 1 allele(MGI details for Bmp3):

skeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005125 cytokine activity IEA--
GO:0008083 growth factor activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for  BMP3  (Your Favorite Gene powered by Ingenuity) (see all 7
 Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
 BMP signaling pathway
 Factors Promoting Cardiogenesis in Vertebrates
 Axonal Guidance Signaling
 Human Embryonic Stem Cell Pluripotency

   GeneDecks  BMP3 for the pathways selected above  
About GeneDecksing

 Gene Network CentralTM Interacting Genes and Proteins Network for  BMP3 


5/18 Interacting proteins for BMP3 (ENSP000002827013) via UniProtKB, MINT, and/or STRING (see all 18 )
InteractantInteraction Details
GeneCardExternal ID(s)
ACVR2BENSP000003403613STRING (score=.941)
ACVR1ENSP000002636403STRING (score=.893)
ACVR2AENSP000002414163STRING (score=.885)
NOGENSP000003281813STRING (score=.864)
FOSENSP000003062453STRING (score=.855)
About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0001503 ossification IEA--
GO:0007267 cell-cell signaling TAS3201241
GO:0007275 multicellular organismal development IEA--
GO:0030154 cell differentiation IEA--
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BMP3
3 Novoseek chemical compound relationships for BMP3 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
admp 81.09 1 14977563 (1)
hydroxyapatite 25.99 4 8390243 (1), 1484504 (1), 10801076 (1)
calcium 0.00 2 9434787 (1), 11769973 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (BMP3)
Millipore RNAi Products for the Analysis of BMP3 Gene knock-down
Abnova Chimera RNAi Products for Gene knock-down (BMP3)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001201

              Sigma-Aldrich siRNA and siRNA Panels for BMP3  
                     Sigma-Aldrich shRNA for BMP3  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001201  

REFSEQ mRNAs for BMP3 gene: 

NM_001201.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001201  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001201
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001201
                                 untagged cDNA clone in CMV expression vector: NM_001201 

Additional cDNA sequence: 

BC096269.2 BC096270.2 BC096271.2 BC117514.1 M22491.1 

3 DOTS entries:

DT.40124774  DT.99977874  DT.97824005 

10 AceView cDNA sequences:

NM_001201 M22491 BX487740 BM985327 BX955675 BM679419 BM720720 CD686479 
AI808858 BU688108 

highest scoring ESTs for BMP3:

M22491 BM720720 BU688108 BC096269 BC096270 BC096271 BF335819 BX487740 CD686479 NM_001201 

Unigene Cluster for BMP3:

Bone morphogenetic protein 3
Hs.387411  [show with all ESTs]
Unigene Representative Sequence: NM_001201


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000395581  ENST00000282701  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BMP3 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for BMP3

1 / 2 / 3

3 probe-sets matching BMP3 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

31314_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M22491 1.00 1.00 1.00 1

208244_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001201 0.60 1.00 0.82 1

208244_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CAGTGTGCAC

SOURCE GeneReport for Unigene cluster: Hs.387411

Expression variation in blood from EXPOLDB for BMP3

UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645
Tissue specificity: Expressed in adult and fetal cartilage

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for BMP3 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
BMP31   -- bone morphogenetic protein 3 82.34(n)
81.76(a)
487826  XM_544948.2  XP_544948.2 
chimpanzee
(Pan troglodytes)
BMP31   -- bone morphogenetic protein 3 98.73(n)
98.09(a)
471189  XM_001144027.1  XP_001144027.1 
cow
(Bos taurus)
BMP31   -- bone morphogenetic protein 3 84.82(n)
86.02(a)
539527  XM_587912.2  XP_587912.2 
rat
(Rattus norvegicus)
Bmp31   -- bone morphogenetic protein 3 81.08(n)
82.15(a)
25667  NM_017105.1  NP_058801.1 
mouse
(Mus musculus)
Bmp31, 5 5 (55.00 cM)5
bone morphogenetic protein 31, 5 81.79(n)1
81.08(a)1
1100751  NM_173404.21  NP_775580.11 
 AK0336445  AK0352995  (see all 9)
About this table        Species with no ortholog for BMP3

ENSEMBL Gene Tree for BMP3
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for BMP3 gene
GDF92  GDF102  BMP152  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/188 NCBI SNPs in BMP3 are shown (see all 188 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 118)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 4 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs76616111,2
A,C,F,H82193833(+) ATTATC/TTCTAT 1 -- ut311Minor allele frequency- T:0.07EU 108
rs14956371,2
A,C,F,H82194698(-) AGTTTC/TTGGGC 1 -- ut314Minor allele frequency- T:0.41EU EA WA 420
--
rs13903201,2
A,C,F,O82169162(+) atgtgA/Ttatta 1 -- ng513Minor allele frequency- T:0.30NA 142
rs50044021,2
C,F,H82194553(+) CAAGTA/GTAATT 1 -- ut314Minor allele frequency- G:0.01EU EA WA 392
rs28680761,2
C,F,H82195897(+) TGTTTG/ATTACC 1 -- ut3112Minor allele frequency- A:0.07NS EU EA WA NA 660
--
rs100077841,2
C,F,H82196714(+) TTTCTT/CAATAA 1 -- ut314Minor allele frequency- C:0.42EU EA WA 352
rs68316411,2
C,F,H82194528(+) ATCAGC/AAACCT 1 -- ut316Minor allele frequency- A:0.16EA NA 512
rs37335491,2
C,F,H82186174(+) TCATCG/AAGATA 1 Q/R mis117Minor allele frequency- A:0.14EA NA MN CSAM EU WA 2872
--
rs131381321,2
C,F82169544(+) TTTACA/CTGGAT 1 -- ng51 tfbs34Minor allele frequency- N:0.00EA NA 216
--
rs100194551,2
C,H82196754(+) GCCAAT/AGTCAA 1 -- ut314Minor allele frequency- A:0.00EU EA WA 420
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HapMap Linkage Disequilibrium images for BMP3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 112263

5 Novoseek disease relationships for BMP3 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
osteosarcoma 43.42 2 7880444 (1), 11986346 (1)
prostatic adenocarcinoma 29.73 3 7880444 (2), 8146069 (1)
calcification 20.34 2 9434787 (1), 1484504 (1)
tumors 0.00 3 16816929 (1), 10846544 (1)
prostate cancer 0.00 1 7880444 (1)
About this table

Human Genome Epidemiology Navigator: BMP3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/96 PubMed articles for BMP3 gene (see all 96 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 651 HGNC: 1070 AceView: BMP3 Ensembl:ENSG00000152785 euGenes: HUgn651
ECgene: BMP3 H-InvDB: BMP3
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for BMP3 Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_3
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for BMP3:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for BMP3 Antibodies for BMP3
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for BMP3 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(BMP3)
 Antibodies (BMP3)
 Search OriGene for BMP3
 Search Tocris compounds for BMP3




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for BMP3

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