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Aliases for BMP3 Gene

Aliases for BMP3 Gene

  • Bone Morphogenetic Protein 3 2 3
  • Osteogenin 2 3 4
  • Bone Morphogenetic Protein 3 (Osteogenic) 2 3
  • Bone Morphogenetic Protein 3A 3 4
  • BMP-3A 3 4
  • BMP-3 3 4
  • Bone Morphogenetic Protein-3 3
  • BMP3A 4

External Ids for BMP3 Gene

Previous GeneCards Identifiers for BMP3 Gene

  • GC04P081849
  • GC04P082247
  • GC04P082410
  • GC04P082309
  • GC04P081952
  • GC04P077696

Summaries for BMP3 Gene

Entrez Gene Summary for BMP3 Gene

  • BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as osteogenin, induces bone formation. [provided by RefSeq, Jul 2008]

GeneCards Summary for BMP3 Gene

BMP3 (Bone Morphogenetic Protein 3) is a Protein Coding gene. Diseases associated with BMP3 include refractive error. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is NODAL.

UniProtKB/Swiss-Prot for BMP3 Gene

  • Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.

Gene Wiki entry for BMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP3 Gene

Genomics for BMP3 Gene

Regulatory Elements for BMP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BMP3 Gene

81,030,965 bp from pter
81,057,531 bp from pter
26,567 bases
Plus strand

Genomic View for BMP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP3 Gene

Proteins for BMP3 Gene

  • Protein details for BMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bone morphogenetic protein 3
    Protein Accession:
    Secondary Accessions:
    • Q4VAS5

    Protein attributes for BMP3 Gene

    472 amino acids
    Molecular mass:
    53372 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for BMP3 Gene

neXtProt entry for BMP3 Gene

Proteomics data for BMP3 Gene at MOPED

Post-translational modifications for BMP3 Gene

  • Glycosylation at Ser68, Thr69, Thr75, Ser83, Asn117, Asn141, Asn175, Asn220, and Asn463
  • Modification sites at PhosphoSitePlus

Other Protein References for BMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BMP3 Gene

Domains for BMP3 Gene

Gene Families for BMP3 Gene

  • BMP :Bone morphogenetic proteins

Graphical View of Domain Structure for InterPro Entry



  • P12645
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with BMP3: view

Function for BMP3 Gene

Molecular function for BMP3 Gene

GENATLAS Biochemistry: bone morphogenetic protein 3 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily)
UniProtKB/Swiss-Prot Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.
UniProtKB/Swiss-Prot Induction: Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.

Gene Ontology (GO) - Molecular Function for BMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 3201241
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0008083 growth factor activity IEA --
GO:0070700 BMP receptor binding IDA 7811286
genes like me logo Genes that share ontologies with BMP3: view

Phenotypes for BMP3 Gene

MGI mutant phenotypes for BMP3:
inferred from 1 alleles
GenomeRNAi human phenotypes for BMP3:
genes like me logo Genes that share phenotypes with BMP3: view

Animal Models for BMP3 Gene

MGI Knock Outs for BMP3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for BMP3 Gene

Localization for BMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP3 Gene


Subcellular locations from

Jensen Localization Image for BMP3 Gene COMPARTMENTS Subcellular localization image for BMP3 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with BMP3: view

Pathways for BMP3 Gene

genes like me logo Genes that share pathways with BMP3: view

Pathways by source for BMP3 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for BMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 3201241
GO:0001503 ossification IEA --
GO:0007267 cell-cell signaling TAS 3201241
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
GO:0030154 cell differentiation --
genes like me logo Genes that share ontologies with BMP3: view

Compounds for BMP3 Gene

(6) Novoseek inferred chemical compound relationships for BMP3 Gene

Compound -log(P) Hits PubMed IDs
admp 80.7 1
ursinus 78.3 3
hydroxyapatite 23.9 3
calcitriol 16.9 1
calcium 0 2
genes like me logo Genes that share compounds with BMP3: view

Transcripts for BMP3 Gene

mRNA/cDNA for BMP3 Gene

(10) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BMP3 Gene

Bone morphogenetic protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BMP3 Gene

No ASD Table

Relevant External Links for BMP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BMP3 Gene

mRNA expression in normal human tissues for BMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BMP3 Gene

This gene is overexpressed in Colon - Sigmoid (8.6), Colon - Transverse (7.3), Esophagus - Muscularis (4.8), Nerve - Tibial (4.5), and Bladder (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BMP3 Gene

SOURCE GeneReport for Unigene cluster for BMP3 Gene Hs.387411

mRNA Expression by UniProt/SwissProt for BMP3 Gene

Tissue specificity: Expressed in adult and fetal cartilage.
genes like me logo Genes that share expressions with BMP3: view

In Situ Assay Products

Orthologs for BMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BMP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BMP3 35
  • 98.73 (n)
  • 98.09 (a)
BMP3 36
  • 98 (a)
(Bos Taurus)
Mammalia BMP3 35
  • 84.82 (n)
  • 86.02 (a)
BMP3 36
  • 85 (a)
(Canis familiaris)
Mammalia BMP3 35
  • 85.45 (n)
  • 85.17 (a)
BMP3 36
  • 85 (a)
(Mus musculus)
Mammalia Bmp3 35
  • 81.72 (n)
  • 81.08 (a)
Bmp3 16
Bmp3 36
  • 80 (a)
(Monodelphis domestica)
Mammalia BMP3 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia BMP3 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Bmp3 35
  • 81 (n)
  • 82.15 (a)
(Gallus gallus)
Aves BMP3 35
  • 68.78 (n)
  • 67.25 (a)
BMP3 36
  • 65 (a)
(Anolis carolinensis)
Reptilia BMP3 36
  • 71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26502 35
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp3 35
  • 63.86 (n)
  • 64.82 (a)
(Danio rerio)
Actinopterygii bmp3 35
  • 60.59 (n)
  • 56.89 (a)
bmp3 36
  • 55 (a)
(Caenorhabditis elegans)
Secernentea unc-129 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for BMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP3 Gene

Gene Tree for BMP3 (if available)
Gene Tree for BMP3 (if available)

Paralogs for BMP3 Gene

Paralogs for BMP3 Gene Pseudogenes for BMP3 Gene

genes like me logo Genes that share paralogs with BMP3: view

Variants for BMP3 Gene

Sequence variations from dbSNP and Humsavar for BMP3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs766916 -- 81,047,711(+) ATAGC(A/G)TTTTC intron-variant
rs903640 -- 81,034,021(+) GTCCT(A/G)TTTGT intron-variant
rs924048 -- 81,049,672(-) TTTTG(C/G)TCACC intron-variant
rs985328 -- 81,052,745(-) GGATT(G/T)GATGG intron-variant
rs1106107 -- 81,032,591(-) GAAGA(C/T)AGGCT intron-variant

Relevant External Links for BMP3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BMP3 Gene

Disorders for BMP3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BMP3 Gene including...

Search for BMP3 Gene in MalaCards »

(5) Novoseek inferred disease relationships for BMP3 Gene

Disease -log(P) Hits PubMed IDs
osteosarcoma 41.7 2
prostatic adenocarcinoma 28.1 3
calcification 18.2 2
tumors 0 2
prostate cancer 0 1

Relevant External Links for BMP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BMP3: view

No data available for UniProtKB/Swiss-Prot for BMP3 Gene

Publications for BMP3 Gene

  1. Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage. (PMID: 15475196) Chen A.L. … Di Cesare P.E. (J. Orthop. Res. 2004) 3 4 23
  2. BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. (PMID: 17924656) Allendorph G.P. … Choe S. (Biochemistry 2007) 3 4 23
  3. BMP signaling components are expressed in human fracture callus. (PMID: 13678778) Kloen P. … Goumans M.J. (Bone 2003) 3 4 23
  4. Role of BMP3 in progression of gastric carcinoma in Chinese people. (PMID: 20238409) Chen X.R. … Ye Z.Y. (World J. Gastroenterol. 2010) 3 23
  5. Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation. (PMID: 9434787) Faucheux C. … AmAcdAce J. (Biochem. Biophys. Res. Commun. 1997) 3 23

Products for BMP3 Gene

Sources for BMP3 Gene

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