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Aliases & Descriptions for BMP3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BMP-3 3 | | BMP-3A 2, 3 | | Osteogenin 3 | | osteogenin 2 |
| | | Descriptions |
|---|
| bone morphogenetic protein 3 2 | | bone morphogenetic protein 3 (osteogenic) 1, 2 | | bone morphogenetic protein-3 2 |
|
| | Search outside databases for aliases for BMP3 genePrevious GC identifers: GC04P081849 GC04P082410 GC04P082309 |
Summaries for BMP3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for BMP3: BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as osteogenin, induces bone formation. [provided by RefSeq] UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossificationGene Wiki entry for BMP3 (Bone_morphogenetic_protein_3) |
Genomic Location for BMP3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the BMP3 gene 
Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q21.21 HGNC cytogenetic band: 4q21BMP3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P082247:
(about GC identifiers)
Start:
|
82,171,143 bp from pter |
End:
|
82,197,709 bp from pter |
Size:
|
26,567 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_016354.18
| Proteins for BMP3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645 (See
protein sequence)Recommended Name: Bone morphogenetic protein 3 precursor Size: 472 amino acids; 53372 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Secreted
PDB structures from and Proteopedia :2QCQ (3D)
 
Secondary accessions: Q4VAS5REFSEQ proteins: NP_001192.2
ENSEMBL proteins: ENSP00000378948 ENSP00000282701
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005615 | extracellular space |
IEA | -- | About this table
Antibodies for BMP3: Assays for BMP3: | Protein
Domains/ Families for BMP3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P12645
ProtoNet protein and cluster: P12645 2 Blocks protein families: IPB001839 Transforming growth factor beta (TGFb) IPB002400 Growth factor cystine knot superfamily signature
UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645Similarity: Belongs to the TGF-beta family | Gene Function for BMP3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| Inhib. RNA: |  | Invitrogen RNAi Products for gene knock-down (BMP3) | |  | Millipore RNAi Products for the Analysis of BMP3 Gene knock-down | |  | Abnova Chimera RNAi Products for Gene knock-down (BMP3) |               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001201
Applied Biosystems Silencer® siRNAs for BMP3
Sigma-Aldrich siRNA and siRNA Panels for BMP3  Sigma-Aldrich shRNA for BMP3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001201                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001201                                  untagged cDNA clone in CMV expression vector: NM_001201 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001201
UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossificationInduction: Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblastsGenatlas biochemistry entry for BMP3:bone morphogenetic protein 3 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily)1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Bmp3):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005125 | cytokine activity |
IEA | -- | | GO:0008083 | growth factor activity |
IEA | -- | About this table | Pathways & Interactions for BMP3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for BMP3 (Your Favorite Gene powered by Ingenuity) (see all 7
) 
Gene Network CentralTM Interacting Genes and Proteins Network for BMP3 
5/18 Interacting proteins for BMP3 (ENSP000002827013) via UniProtKB, MINT, and/or STRING (see all 18
)About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001503 | ossification |
IEA | -- | | GO:0007267 | cell-cell signaling |
TAS | 3201241 | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IEA | -- | About this table
|
Drugs & Compounds for BMP3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for BMP3 3 Novoseek chemical compound relationships for BMP3 gene
About this table
|
Transcripts for BMP3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
| Inhib. RNA: |  | Invitrogen RNAi Products for gene knock-down (BMP3) | |  | Millipore RNAi Products for the Analysis of BMP3 Gene knock-down | |  | Abnova Chimera RNAi Products for Gene knock-down (BMP3) |               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001201
Sigma-Aldrich siRNA and siRNA Panels for BMP3  Sigma-Aldrich shRNA for BMP3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001201 REFSEQ mRNAs for BMP3 gene: NM_001201.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001201               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001201                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001201                                  untagged cDNA clone in CMV expression vector: NM_001201  Additional cDNA sequence: BC096269.2 BC096270.2 BC096271.2 BC117514.1 M22491.1 3 DOTS entries: DT.40124774 DT.99977874 DT.97824005 10 AceView cDNA sequences:NM_001201 M22491 BX487740 BM985327 BX955675 BM679419 BM720720 CD686479 AI808858 BU688108
highest scoring ESTs for BMP3:M22491 BM720720 BU688108 BC096269 BC096270 BC096271 BF335819 BX487740 CD686479 NM_001201 Unigene Cluster for BMP3: Bone morphogenetic protein 3 Hs.387411 [show with all ESTs]Unigene Representative Sequence: NM_001201
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000395581
ENST00000282701
|
Expression for BMP3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| BMP3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for BMP3
1 / 2 / 3 3 probe-sets matching BMP3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CAGTGTGCAC
SOURCE GeneReport for Unigene cluster: Hs.387411
Expression variation in blood from EXPOLDB for BMP3 UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645Tissue specificity: Expressed in adult and fetal cartilage |
Orthologs for BMP3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for BMP3 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for BMP3
ENSEMBL Gene Tree for BMP3 | Paralogs for BMP3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for BMP3 gene
- GDF92 GDF102 BMP152
|
SNPs/Variants for BMP3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for BMP3 (up to first 250kb)
|
Disorders & Mutations for BMP3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 112263
5 Novoseek disease relationships for BMP3 gene
About this table
Human Genome Epidemiology Navigator: BMP3 (1 document)
|
Medical News for BMP3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for BMP3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/96 PubMed articles for BMP3 gene (see all 96
):- Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage. (PubMed id 15475196)1, 3, 4 Chen A.L.... Di Cesare P.E. (2004)
- BMP signaling components are expressed in human fracture callus. (PubMed id 13678778)1, 3, 4 Kloen P....Goumans M.J. (2003)
- Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. (PubMed id 15269709)3, 4 Kang Q.... He T.-C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Bone morphogenetic protein-3 is a negative regulator of bone density. (PubMed id 11138004)3, 4 Daluiski A.... Lyons K.M. (2001)
- Novel regulators of bone formation: molecular clones and activities. (PubMed id 3201241)3, 4 Wozney J.M.... Wang E.A. (1988)
- BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. (PubMed id 17924656)1, 3 Allendorph G.P....Choe S. (2007)
- Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3. (PubMed id 2004778)1, 3 Tabas J.A....Kaplan F.S. (1991)
- Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation. (PubMed id 9434787)1, 3 Faucheux C....Amedee J. (1997)
- Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development. (PubMed id 18311777)3 Loh K....Whitehall V.L. (2008)
|
Search for BMP3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BMP3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing BMP3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BMP3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for BMP3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for BMP3:

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