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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BMP3 Gene

protein-coding   GIFtS: 61
GCID: GC04P081952

bone morphogenetic protein 3

(Previous name: bone morphogenetic protein 3 (osteogenic) )
 Explore 20 diseases affiliated with
BMP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BMP3    

Aliases
for BMP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Bone Morphogenetic Protein 31 2     Bone Morphogenetic Protein-32
Bone Morphogenetic Protein 3 (Osteogenic)1 2     Osteogenin3
Bone Morphogenetic Protein 3A2 3     BMP3A3
BMP-32 3     Osteogenin3
BMP-3A2 3     

External Ids:    HGNC: 10701   Entrez Gene: 6512   Ensembl: ENSG000001527857   OMIM: 1122635   UniProtKB: P126453   

Export aliases for BMP3 gene to outside databases

Previous GC identifers: GC04P081849 GC04P082247 GC04P082410 GC04P082309 GC04P077696


Summaries
for BMP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BMP3:
BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as
osteogenin, induces bone formation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645
Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce
osteoprogenitor differentitation and ossification

Gene Wiki entry for BMP3 (Bone morphogenetic protein 3)


Genomic Views
for BMP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMP3 gene promoter:
         AP-1   ATF-2   MIF-1   GATA-2   GATA-1   Evi-1   AREB6   MZF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BMP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for BMP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21

BMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P081952:  view genomic region     (about GC identifiers)

Start:
 81,952,119 bp from pter      End:
 81,978,685 bp from pter
Size:
 26,567 bases      Orientation:
 plus strand

Proteins
for BMP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645 (See protein sequence)
Recommended Name: Bone morphogenetic protein 3 precursor  
Size: 472 amino acids; 53372 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for BMP3:
2QCQ (3D)    
Secondary accessions: Q4VAS5

Explore the universe of human proteins at neXtProt for BMP3: NX_P12645

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P12645

    • BMP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001192.2  
    ENSEMBL proteins: 
     ENSP00000282701  

    Human Recombinant Protein Products: 
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    Novus Biologicals BMP3 Proteins
    Novus Biologicals BMP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BMP3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0031988membrane-bounded vesicle ----


    BMP3 for ontologies           About GeneDecksing



    BMP3 Antibody Products: 
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    Uscn ELISAs and CLIAs for BMP3

    Protein Domains /
    Families
    for BMP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BMP3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR017197 BMP3/GDF10
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P12645

    ProtoNet protein and cluster: P12645

    2 Blocks protein families:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645
    Similarity: Belongs to the TGF-beta family


    Function
    for BMP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645
    Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce
    osteoprogenitor differentitation and ossification
    Induction: Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts

         Genatlas biochemistry entry for BMP3:
    bone morphogenetic protein 3 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMP3
    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP3 (see all 72):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-128 hsa-miR-3653 hsa-miR-138-2* hsa-miR-3613-3p hsa-miR-4273 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: BMP3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BMP3 (see all 7)
    OriGene shRNA RFP: BMP3
    OriGene siRNA: BMP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BMP3

    Clone
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    Search LifeMap BioReagents cell lines for BMP3

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS3201241
    GO:0005125cytokine activity IEA--
    GO:0008083growth factor activity IEA--
    GO:0070700BMP receptor binding IPI7811286


    BMP3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for BMP3:
     Increased cell death in HCC-19 

    Animal Models:
         Mouse knock-out Bmp3tm1Kml for BMP3
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Bmp3):
     skeleton 

    BMP3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BMP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/14 pathways (see all 14)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2PEDF Induced Signaling
    8/11 pathways (see all 11)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    3GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    4TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51

    5/71 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BMP3 (see all 71)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    1 BioSystems Pathway for BMP3 
        Adipogenesis


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BMP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for BMP3 (P126452, 3 ENSP000002827014) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WFIKKN1Q96NZ82, 3, ENSP000003247634MINT-8044158 I2D: score=1 STRING: ENSP00000324763
    WFIKKN2Q8TEU82, 3, ENSP000003111844MINT-8044382 I2D: score=1 STRING: ENSP00000311184
    TGFB1P011373, ENSP000002219304I2D: score=1 STRING: ENSP00000221930
    COL4A1P024623, ENSP000003649794I2D: score=1 STRING: ENSP00000364979
    COL4A2P085723, ENSP000003536544I2D: score=1 STRING: ENSP00000353654
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS3201241
    GO:0001503ossification IEA--
    GO:0007267cell-cell signaling TAS3201241
    GO:0030154cell differentiation IEA--
    GO:0040007growth IEA--


    BMP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BMP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BMP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BMP3
    6 Novoseek chemical compound relationships for BMP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    admp 80.7 1 14977563 (1)
    ursinus 78.3 4 8390243 (1), 1787832 (1), 16364199 (1)
    hydroxyapatite 23.9 4 8390243 (1), 1484504 (1), 10801076 (1)
    calcitriol 16.9 1 7890141 (1)
    calcium 0 2 9434787 (1), 11769973 (1)
    dexamethasone 0 1 8891893 (1)

    Search CenterWatch for drugs/clinical trials and news about BMP3 

    Transcripts
    for BMP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BMP3 gene: 
    NM_001201.2  

    Unigene Cluster for BMP3:

    Bone morphogenetic protein 3
    Hs.387411  [show with all ESTs]
    Unigene Representative Sequence: NM_001201
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000282701(uc003hmg.4)

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    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP3 (see all 72):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-128 hsa-miR-3653 hsa-miR-138-2* hsa-miR-3613-3p hsa-miR-4273 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: BMP3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC096269.2 BC096270.2 BC096271.2 BC117514.1 M22491.1 

    3 DOTS entries:

    DT.40124774  DT.99977874  DT.97824005 

    10 AceView cDNA sequences:

    NM_001201 M22491 BX487740 BM985327 CD686479 BX955675 BM720720 BM679419 
    AI808858 BU688108 

    GeneLoc Exon Structure


    Expression
    for BMP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BMP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGTGTGCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BMP3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/17 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 17) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod PerichondriumEndochondral PreosteoblastsBone
    BoneCervical VertebraeEndochondral PreosteoblastsBone
    BoneLumbar VertebraeEndochondral PreosteoblastsBone
    BoneSacral VertebraeEndochondral PreosteoblastsBone
    BoneStylopod PerichondriumEndochondral PreosteoblastsBone
    BoneThoracic RibEndochondral PreosteoblastsBone
    BoneThoracic VertebraeEndochondral PreosteoblastsBone
    BoneZeugopod PerichondriumEndochondral PreosteoblastsBone
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    BoneAutopod Long BoneBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BMP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BMP3

    SOURCE GeneReport for Unigene cluster: Hs.387411

    UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645
    Tissue specificity: Expressed in adult and fetal cartilage

        SABiosciences Expression via Pathway-Focused PCR Arrays including BMP3 (see all 6): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for BMP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for BMP3 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BMP31 bone morphogenetic protein 3 68.93(n)
    67.18(a)    		   422581  NM_001034819.1  NP_001029991.1 
    lizard
    (Anolis carolinensis)    		 Reptilia BMP36
    		 --
    		 82(a)
    		 1 ↔ 1
    		 5(42397026-42406470)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.265022 Xenopus laevis mRNA for xBMP-3, complete cds 79.96(n)    AB059563.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii bmp31 bone morphogenetic protein 3 60.67(n)
    56.89(a)    		   777717  NM_001077765.1  NP_001071233.1 


    ENSEMBL Gene Tree for BMP3 (if available)
    TreeFam Gene Tree for BMP3 (if available) 

    Paralogs
    for BMP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BMP3 gene
    GDF52  GDF32  BMP52  GDF62  BMP8B2  BMP42  GDF72  GDF22  
    BMP22  BMP102  BMP72  GDF102  GDF12  BMP8A2  BMP62  
    10 SIMAP similar genes for BMP3 using alignment to 15 protein entries:     BMP3_HUMAN (see all proteins):
    BMPY    BMP5    BMP6    BMP2    GDF5    GDF8
    INHA    GDF10    NODAL    TGFB1

    BMP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BMP3
    PGOHUM00000238478


    Genomic Variants
    for BMP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): BMP3
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BMP3
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP3

    Disorders / Diseases
    for BMP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BMP3 for disorders           About GeneDecksing

    OMIM gene information: 112263    OMIM disorders: --

    20 diseases for BMP3:    About MalaCards
    malignant peripheral nerve sheath tumor    maturity-onset diabetes of the young    osteogenesis imperfecta    tooth erosion
    pleomorphic adenoma    otosclerosis    osteomalacia    prostate adenocarcinoma
    osteosarcoma    prostate cancer    adenoma    prostatitis
    adenocarcinoma    periodontitis    colorectal cancer    fibrosis
    neuronitis    carcinoma    breast cancer    pancreatitis

    5 Novoseek disease relationships for BMP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteosarcoma 41.7 2 7880444 (1), 11986346 (1)
    prostatic adenocarcinoma 28.1 3 7880444 (2), 8146069 (1)
    calcification 18.2 2 9434787 (1), 1484504 (1)
    tumors 0 3 16816929 (1), 10846544 (1)
    prostate cancer 0 1 7880444 (1)

    Human Genome Epidemiology (HuGE) Navigator: BMP3 (5 documents)

    Export disorders for BMP3 gene to outside databases

    Publications
    for BMP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BMP3 gene, integrated from 9 sources (see all 108):
    (articles sorted by number of sources associating them with BMP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. (PubMed id 17924656)1, 2, 9 Allendorph G.P....Choe S. (2007)
    2. Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage. (PubMed id 15475196)1, 2, 9 Chen A.L.... Di Cesare P.E. (2004)
    3. BMP signaling components are expressed in human fracture callus. (PubMed id 13678778)1, 2, 9 Kloen P....Goumans M.J. (2003)
    4. Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. (PubMed id 15269709)1, 2 Kang Q.... He T.-C. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Bone morphogenetic protein-3 is a negative regulator of bone density. (PubMed id 11138004)1, 2 Daluiski A.... Lyons K.M. (2001)
    7. Novel regulators of bone formation: molecular clones and activities. (PubMed id 3201241)1, 2 Wozney J.M.... Wang E.A. (1988)
    8. BMP-3 promotes mesenchymal stem cell proliferation th rough the TGF-beta/activin signaling pathway. (PubMed id 20143330)1, 9 Stewart A....Yang K. (2010)
    9. Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3. (PubMed id 2004778)1, 9 Tabas J.A....Kaplan F.S. (1991)
    10. Role of BMP3 in progression of gastric carcinoma in C hinese people. (PubMed id 20238409)1, 9 Chen X.R....Ye Z.Y. (2010)

    External Searches for BMP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing BMP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 651 HGNC: 1070 AceView: BMP3 Ensembl:ENSG00000152785 euGenes: HUgn651
    ECgene: BMP3 H-InvDB: BMP3

    Other Databases showing BMP3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BMP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BMP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_3

    Intellectual Property
    for BMP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BMP3 gene:
    Search GeneIP for patents involving BMP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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