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BMP3 Gene

protein-coding   GIFtS: 61
GCID: GC04P081952

Bone Morphogenetic Protein 3

(Previous name: bone morphogenetic protein 3 (osteogenic))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bone Morphogenetic Protein 31 2     BMP-3A2 3
Bone Morphogenetic Protein 3 (Osteogenic)1 2     Bone Morphogenetic Protein-32
osteogenin1 2     BMP3A3
Bone Morphogenetic Protein 3A2 3     Osteogenin3
BMP-32 3     

External Ids:    HGNC: 10701   Entrez Gene: 6512   Ensembl: ENSG000001527857   OMIM: 1122635   UniProtKB: P126453   

Export aliases for BMP3 gene to outside databases

Previous GC identifers: GC04P081849 GC04P082247 GC04P082410 GC04P082309 GC04P077696


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BMP3 Gene:
BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as
osteogenin, induces bone formation. (provided by RefSeq, Jul 2008)

GeneCards Summary for BMP3 Gene:
BMP3 (bone morphogenetic protein 3) is a protein-coding gene. Diseases associated with BMP3 include tooth erosion, and prostate adenocarcinoma. GO annotations related to this gene include growth factor activity and receptor binding. An important paralog of this gene is GDF15.

UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645
Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce
osteoprogenitor differentitation and ossification

Gene Wiki entry for BMP3 (Bone morphogenetic protein 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BMP3 gene promoter:
         AP-1   ATF-2   MIF-1   GATA-2   GATA-1   Evi-1   AREB6   MZF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP3 promoter sequence
   Search Chromatin IP Primers for BMP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21

BMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P081952:  view genomic region     (about GC identifiers)

Start:
81,952,119 bp from pter      End:
81,978,685 bp from pter
Size:
26,567 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645 (See protein sequence)
Recommended Name: Bone morphogenetic protein 3 precursor  
Size: 472 amino acids; 53372 Da
Subunit: Homodimer; disulfide-linked (By similarity)
1 PDB 3D structure from and Proteopedia for BMP3:
2QCQ (3D)    
Secondary accessions: Q4VAS5

Explore the universe of human proteins at neXtProt for BMP3: NX_P12645

Explore proteomics data for BMP3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser68, Thr69, Thr75, Ser83, Asn117, Asn141, Asn175, Asn220, Asn463
  • Modification sites at PhosphoSitePlus

  • See BMP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001192.2  
    ENSEMBL proteins: 
     ENSP00000282701  

    BMP3 Human Recombinant Protein Products:

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    OriGene Purified Protein for BMP3
    OriGene Protein Over-expression Lysate for BMP3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for BMP3
    GenScript Custom Purified and Recombinant Proteins Services for BMP3
    Novus Biologicals BMP3 Proteins
    Novus Biologicals BMP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BMP3

    BMP3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for BMP3 (BMP-3)
    OriGene Antibodies for BMP3
    OriGene Custom Antibody Services for BMP3
    Novus Biologicals BMP3 Antibodies
    Abcam antibodies for BMP3
    Cloud-Clone Corp. Antibodies for BMP3
    ThermoFisher Antibody for BMP3
    LSBio Antibodies in human, mouse, rat for BMP3

    BMP3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BMP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BMP3
    Cloud-Clone Corp. CLIAs for BMP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BMP: Bone morphogenetic proteins

    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR017197 BMP3/GDF10
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P12645

    ProtoNet protein and cluster: P12645

    2 Blocks protein domains:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645
    Similarity: Belongs to the TGF-beta family


    BMP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP3_HUMAN, P12645
    Function: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce
    osteoprogenitor differentitation and ossification
    Induction: Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts

         Genatlas biochemistry entry for BMP3:
    bone morphogenetic protein 3 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS3201241
    GO:0005125cytokine activity IEA--
    GO:0008083growth factor activity IEA--
    GO:0070700BMP receptor binding IPI7811286
         
    BMP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BMP3:
     Increased cell death in HCC-19 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Bmp3):
     skeleton 

    BMP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bmp3tm1Kml for BMP3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BMP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BMP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BMP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BMP3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat BMP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMP3 (see all 72):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-128 hsa-miR-3653 hsa-miR-138-2* hsa-miR-3613-3p hsa-miR-4273 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidBMP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BMP3
    Predesigned siRNA for gene silencing in human, mouse, rat BMP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BMP3

    Clone
    Products:
         
    OriGene clones in human, mouse for BMP3 (see all 5)
    OriGene ORF clones in mouse, rat for BMP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP3 (NM_001201)
    Sino Biological Human cDNA Clone for BMP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BMP3
    Browse ESI BIO Cell Lines and PureStem Progenitors for BMP3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BMP3_HUMAN, P12645: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    BMP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BMP3 About   (see all 18)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BMP3 (see all 71)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    1 BioSystems Pathway for BMP3
        Adipogenesis



        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMP3 (see all 6): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BMP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for BMP3 (P126452, 3 ENSP000002827014) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WFIKKN1Q96NZ82, 3, ENSP000003247634MINT-8044158 I2D: score=1 STRING: ENSP00000324763
    WFIKKN2Q8TEU82, 3, ENSP000003111844MINT-8044382 I2D: score=1 STRING: ENSP00000311184
    TGFB1P011373, ENSP000002219304I2D: score=1 STRING: ENSP00000221930
    COL4A1P024623, ENSP000003649794I2D: score=1 STRING: ENSP00000364979
    COL4A2P085723, ENSP000003536544I2D: score=1 STRING: ENSP00000353654
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS3201241
    GO:0001503ossification IEA--
    GO:0007267cell-cell signaling TAS3201241
    GO:0030154cell differentiation IEA--
    GO:0040007growth IEA--

    BMP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BMP3

    6 Novoseek inferred chemical compound relationships for BMP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    admp 80.7 1 14977563 (1)
    ursinus 78.3 4 8390243 (1), 1787832 (1), 16364199 (1)
    hydroxyapatite 23.9 4 8390243 (1), 1484504 (1), 10801076 (1)
    calcitriol 16.9 1 7890141 (1)
    calcium 0 2 9434787 (1), 11769973 (1)
    dexamethasone 0 1 8891893 (1)



    BMP3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BMP3 gene: 
    NM_001201.2  

    Unigene Cluster for BMP3:

    Bone morphogenetic protein 3
    Hs.387411  [show with all ESTs]
    Unigene Representative Sequence: NM_001201
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000282701(uc003hmg.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BMP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMP3 (see all 72):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-128 hsa-miR-3653 hsa-miR-138-2* hsa-miR-3613-3p hsa-miR-4273 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidBMP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BMP3
    Predesigned siRNA for gene silencing in human, mouse, rat BMP3
    Clone
    Products:
         
    OriGene clones in human, mouse for BMP3 (see all 5)
    OriGene ORF clones in mouse, rat for BMP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP3 (NM_001201)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BMP3
    OriGene qSTAR qPCR primer pairs in human, mouse for BMP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BMP3
      QuantiTect SYBR Green Assays in human, mouse, rat BMP3
      QuantiFast Probe-based Assays in human, mouse, rat BMP3

    Additional mRNA sequence: 

    BC096269.2 BC096270.2 BC096271.2 BC117514.1 M22491.1 

    3 DOTS entries:

    DT.40124774  DT.99977874  DT.97824005 

    10 AceView cDNA sequences:

    M22491 NM_001201 BX955675 BM985327 BM720720 BM679419 BX487740 CD686479 
    AI808858 BU688108 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BMP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTGTGCAC
    BMP3 Expression
    About this image


    BMP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Endochondral Preosteoblasts Zeugopod Perichondrium
             Endochondral Facial Bones
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             Dental Papilla Cells Dental Papilla
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Limb (Muscoskeletal System)
             Autopod
    BMP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BMP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.387411

    UniProtKB/Swiss-Prot: BMP3_HUMAN, P12645
    Tissue specificity: Expressed in adult and fetal cartilage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMP3 (see all 6): 
              Osteogenesis in human mouse rat
              Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BMP3
    OriGene qSTAR qPCR primer pairs in human, mouse for BMP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BMP3
    QuantiTect SYBR Green Assays in human, mouse, rat BMP3
    QuantiFast Probe-based Assays in human, mouse, rat BMP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BMP3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp31 , 5 bone morphogenetic protein 31, 5 81.72(n)1
    81.08(a)1
      5 (48.24 cM)5
    1100751  NM_173404.31  NP_775580.11 
     988544395 
    chicken
    (Gallus gallus)
    Aves BMP31 bone morphogenetic protein 3 68.78(n)
    67.25(a)
      422581  NM_001034819.1  NP_001029991.1 
    lizard
    (Anolis carolinensis)
    Reptilia BMP36
    bone morphogenetic protein 3
    71(a)
    1 ↔ 1
    5(42396640-42408931)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.265022 Xenopus laevis mRNA for xBMP-3, complete cds 79.96(n)    AB059563.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bmp31 bone morphogenetic protein 3 60.59(n)
    56.89(a)
      777717  NM_001077765.1  NP_001071233.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-1296
    Protein UNC-129 (unc-129) mRNA, complete cds
    20(a)
    1 → many
    IV(9002837-9005410) WBGene00006852


    ENSEMBL Gene Tree for BMP3 (if available)
    TreeFam Gene Tree for BMP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for BMP3 gene
    GDF152  GDF92  NODAL2  GDF102  BMP152  
    11 SIMAP similar genes for BMP3 using alignment to 15 protein entries:     BMP3_HUMAN (see all proteins):
    BMPY    BMP5    BMP6    BMP2    BMP4    GDF5
    GDF8    INHA    GDF10    NODAL    TGFB1

    BMP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for BMP3
    PGOHUM00000238478


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BMP3 (see all 634)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs13903201,2
    C,F,O,A,H--81950138(+) ATGTGA/TTATTA 1 -- us2k113Minor allele frequency- T:0.36NA CSA WA EA 514
    rs1180269031,2
    C,F--81950249(+) TTAGGA/CTAGAA 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1835749551,2
    --81950340(+) TAAAAA/GGAATG 1 -- us2k10--------
    rs1874310521,2
    --81950386(+) TGGAGA/GCATGG 1 -- us2k10--------
    rs1919564881,2
    --81950467(+) AATAGA/TCATTG 1 -- us2k10--------
    rs131381321,2
    C,F--81950520(+) TTTACA/CTGGAT 1 -- us2k1 tfbs312Minor allele frequency- N:0.00EA NA WA 584
    rs1847104381,2
    --81950551(+) TAAATG/TCTAAT 1 -- us2k10--------
    rs1875598601,2
    --81950565(+) ACTATC/TAATAG 1 -- us2k10--------
    rs1924759531,2
    C--81950632(+) TGTCAC/TTTACT 1 -- us2k10--------
    rs131383611,2
    C,F,H--81950655(+) GCCTCA/GGTTTC 1 -- us2k118Minor allele frequency- G:0.10NS EA NA WA 2342

    HapMap Linkage Disequilibrium report for BMP3 (81952119 - 81978685 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BMP3: --
    Human Gene Mutation Database (HGMD): BMP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BMP3
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 112263    OMIM disorders: --

    Selected diseases for BMP3 (see all 24):    
    About MalaCards
    tooth erosion    prostate adenocarcinoma    otosclerosis    pleomorphic adenoma
    osteogenesis imperfecta    osteomalacia    malignant peripheral nerve sheath tumor    refractive error
    osteosarcoma    maturity-onset diabetes of the young    short stature    myopia
    prostatitis    periodontitis    adenoma    adenocarcinoma
    prostate cancer    colorectal cancer    cervicitis    pancreatitis


    BMP3 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for BMP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteosarcoma 41.7 2 7880444 (1), 11986346 (1)
    prostatic adenocarcinoma 28.1 3 7880444 (2), 8146069 (1)
    calcification 18.2 2 9434787 (1), 1484504 (1)
    tumors 0 3 16816929 (1), 10846544 (1)
    prostate cancer 0 1 7880444 (1)

    Genetic Association Database (GAD): BMP3
    Human Genome Epidemiology (HuGE) Navigator: BMP3 (5 documents)

    Export disorders for BMP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BMP3 gene, integrated from 10 sources (see all 115):
    (articles sorted by number of sources associating them with BMP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors. (PubMed id 17924656)1, 2, 9 Allendorph G.P....Choe S. (Biochemistry 2007)
    2. Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage. (PubMed id 15475196)1, 2, 9 Chen A.L.... Di Cesare P.E. (J. Orthop. Res. 2004)
    3. BMP signaling components are expressed in human fracture callus. (PubMed id 13678778)1, 2, 9 Kloen P....Goumans M.J. (Bone 2003)
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    7. Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. (PubMed id 15269709)1, 2 Kang Q.... He T.-C. (Gene Ther. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Bone morphogenetic protein-3 is a negative regulator of bone density. (PubMed id 11138004)1, 2 Daluiski A.... Lyons K.M. (Nat. Genet. 2001)
    10. Novel regulators of bone formation: molecular clones and activities. (PubMed id 3201241)1, 2 Wozney J.M.... Wang E.A. (Science 1988)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 651 HGNC: 1070 AceView: BMP3 Ensembl:ENSG00000152785 euGenes: HUgn651
    ECgene: BMP3 H-InvDB: BMP3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BMP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP3 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BMP3 gene:
    Search GeneIP for patents involving BMP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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