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Aliases for BMP2K Gene

Aliases for BMP2K Gene

  • BMP2 Inducible Kinase 2 3 5
  • EC 2.7.11.1 4 63
  • BIKE 3 4
  • HRIHFB2017 3

External Ids for BMP2K Gene

Previous GeneCards Identifiers for BMP2K Gene

  • GC04P080090
  • GC04P080155
  • GC04P080054
  • GC04P079916
  • GC04P079697
  • GC04P075443

Summaries for BMP2K Gene

Entrez Gene Summary for BMP2K Gene

  • This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BMP2K Gene

BMP2K (BMP2 Inducible Kinase) is a Protein Coding gene. Diseases associated with BMP2K include exotropia. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AAK1.

UniProtKB/Swiss-Prot for BMP2K Gene

  • May be involved in osteoblast differentiation.

Gene Wiki entry for BMP2K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP2K Gene

Genomics for BMP2K Gene

Regulatory Elements for BMP2K Gene

Promoters for BMP2K Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BMP2K on UCSC Golden Path with GeneCards custom track

Genomic Location for BMP2K Gene

Chromosome:
4
Start:
78,776,342 bp from pter
End:
78,916,372 bp from pter
Size:
140,031 bases
Orientation:
Plus strand

Genomic View for BMP2K Gene

Genes around BMP2K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BMP2K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BMP2K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP2K Gene

Proteins for BMP2K Gene

  • Protein details for BMP2K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSY1-BMP2K_HUMAN
    Recommended name:
    BMP-2-inducible protein kinase
    Protein Accession:
    Q9NSY1
    Secondary Accessions:
    • O94791
    • Q4W5H2
    • Q8IYF2
    • Q8N2G7
    • Q8NHG9
    • Q9NTG8

    Protein attributes for BMP2K Gene

    Size:
    1161 amino acids
    Molecular mass:
    129172 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for BMP2K Gene

    Alternative splice isoforms for BMP2K Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BMP2K Gene

Proteomics data for BMP2K Gene at MOPED

Post-translational modifications for BMP2K Gene

Other Protein References for BMP2K Gene

Antibody Products

Domains & Families for BMP2K Gene

Gene Families for BMP2K Gene

Protein Domains for BMP2K Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSY1

UniProtKB/Swiss-Prot:

BMP2K_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with BMP2K: view

Function for BMP2K Gene

Molecular function for BMP2K Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May be involved in osteoblast differentiation.

Enzyme Numbers (IUBMB) for BMP2K Gene

Gene Ontology (GO) - Molecular Function for BMP2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA,IBA --
genes like me logo Genes that share ontologies with BMP2K: view
genes like me logo Genes that share phenotypes with BMP2K: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BMP2K Gene

Localization for BMP2K Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP2K Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BMP2K Gene COMPARTMENTS Subcellular localization image for BMP2K gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for BMP2K Gene

Pathways & Interactions for BMP2K Gene

genes like me logo Genes that share pathways with BMP2K: view

Pathways by source for BMP2K Gene

1 KEGG pathway for BMP2K Gene

Gene Ontology (GO) - Biological Process for BMP2K Gene

None

No data available for SIGNOR curated interactions for BMP2K Gene

Drugs & Compounds for BMP2K Gene

(1) Drugs for BMP2K Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for BMP2K Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with BMP2K: view

Transcripts for BMP2K Gene

Unigene Clusters for BMP2K Gene

BMP2 inducible kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BMP2K Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - -
SP3:
SP4: -

Relevant External Links for BMP2K Gene

GeneLoc Exon Structure for
BMP2K
ECgene alternative splicing isoforms for
BMP2K

Expression for BMP2K Gene

mRNA expression in normal human tissues for BMP2K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BMP2K Gene

This gene is overexpressed in Brain (41.3) and Serum (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BMP2K Gene



SOURCE GeneReport for Unigene cluster for BMP2K Gene Hs.146551

genes like me logo Genes that share expression patterns with BMP2K: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for BMP2K Gene

Orthologs for BMP2K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BMP2K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BMP2K 35
  • 99.31 (n)
  • 99.57 (a)
BMP2K 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BMP2K 36
  • 80 (a)
OneToOne
BMP2K 35
  • 86.01 (n)
  • 87.11 (a)
dog
(Canis familiaris)
Mammalia BMP2K 35
  • 90.76 (n)
  • 90.03 (a)
BMP2K 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bmp2k 16
Bmp2k 35
  • 83.6 (n)
  • 83.13 (a)
Bmp2k 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BMP2K 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BMP2K 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bmp2k 35
  • 83.22 (n)
  • 82.33 (a)
chicken
(Gallus gallus)
Aves BMP2K 36
  • 72 (a)
OneToOne
BMP2K 35
  • 80.02 (n)
  • 87.56 (a)
lizard
(Anolis carolinensis)
Reptilia BMP2K 36
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9335 35
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp2k 35
  • 68.64 (n)
  • 67.64 (a)
Str.14011 35
zebrafish
(Danio rerio)
Actinopterygii bmp2k 36
  • 61 (a)
OneToOne
bmp2k 35
  • 68.33 (n)
  • 72.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nak 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sel-5 36
  • 17 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AKL1 36
  • 15 (a)
ManyToMany
ARK1 36
  • 22 (a)
ManyToMany
PRK1 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for BMP2K:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP2K Gene

ENSEMBL:
Gene Tree for BMP2K (if available)
TreeFam:
Gene Tree for BMP2K (if available)

Paralogs for BMP2K Gene

Paralogs for BMP2K Gene

(5) SIMAP similar genes for BMP2K Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for BMP2K Gene

genes like me logo Genes that share paralogs with BMP2K: view

Variants for BMP2K Gene

Sequence variations from dbSNP and Humsavar for BMP2K Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_040388 A lung squamous cell carcinoma sample
rs56143363 - 78,845,016(+) AAAAG(A/T)TGGAG reference, missense
rs55782848 - 78,851,036(+) CTCCC(A/G)TAACA reference, missense
rs2288255 - 78,865,702(-) GTTAC(C/T)GAATT reference, missense
VAR_051619 -

Structural Variations from Database of Genomic Variants (DGV) for BMP2K Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV Deletion 23290073
esv26247 CNV Loss 19812545
nsv879504 CNV Loss 21882294
nsv508291 CNV Loss 20534489
esv990407 CNV Insertion 20482838
nsv829979 CNV Gain 17160897
esv272040 CNV Insertion 20981092
nsv822627 CNV Loss 20364138

Variation tolerance for BMP2K Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.80; 83.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BMP2K Gene

HapMap Linkage Disequilibrium report
BMP2K
Human Gene Mutation Database (HGMD)
BMP2K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMP2K Gene

Disorders for BMP2K Gene

MalaCards: The human disease database

(1) MalaCards diseases for BMP2K Gene - From: DISEASES

Disorder Aliases PubMed IDs
exotropia
  • divergent concomitant strabismus
- elite association - COSMIC cancer census association via MalaCards
Search BMP2K in MalaCards View complete list of genes associated with diseases

Relevant External Links for BMP2K

Genetic Association Database (GAD)
BMP2K
Human Genome Epidemiology (HuGE) Navigator
BMP2K
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BMP2K
genes like me logo Genes that share disorders with BMP2K: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BMP2K Gene

Publications for BMP2K Gene

  1. A novel genetic variant of BMP2K contributes to high myopia. (PMID: 19927351) Liu H.P. … Tsai F.J. (J. Clin. Lab. Anal. 2009) 3 23 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb. (PMID: 23211419) Krieger J.R. … McGlade C.J. (Mol. Cell Proteomics 2013) 3
  4. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PMID: 20811636) Giannone R.J. … Liu Y. (PLoS ONE 2010) 3
  5. The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor. (PMID: 19336002) Zhou W. … Zhang L. (BMB Rep 2009) 3

Products for BMP2K Gene

Sources for BMP2K Gene

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