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BMP2K Gene

protein-coding   GIFtS: 60
GCID: GC04P079697

BMP2 Inducible Kinase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BMP2 Inducible Kinase1 2
BIKE2 3
EC 2.7.11.13 8
BMP-2-Inducible Protein Kinase2
BIKe3

External Ids:    HGNC: 180411   Entrez Gene: 555892   Ensembl: ENSG000001387567   UniProtKB: Q9NSY13   

Export aliases for BMP2K gene to outside databases

Previous GC identifers: GC04P080090 GC04P080155 GC04P080054 GC04P079916 GC04P075443


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BMP2K Gene:
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role
in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced
differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear
localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with
a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for BMP2K Gene:
BMP2K (BMP2 inducible kinase) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and phosphatase regulator activity. An important paralog of this gene is AAK1.

UniProtKB/Swiss-Prot: BMP2K_HUMAN, Q9NSY1
Function: May be involved in osteoblast differentiation

Gene Wiki entry for BMP2K Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BMP2K gene promoter:
         Oct-B1   HFH-3   Max1   FOXI1   S8   c-Myc   En-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP2K promoter sequence
   Search Chromatin IP Primers for BMP2K

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMP2K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21.21

BMP2K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP2K gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P079697:  view genomic region     (about GC identifiers)

Start:
79,697,496 bp from pter      End:
79,837,526 bp from pter
Size:
140,031 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BMP2K_HUMAN, Q9NSY1 (See protein sequence)
Recommended Name: BMP-2-inducible protein kinase  
Size: 1161 amino acids; 129172 Da
Secondary accessions: O94791 Q8IYF2 Q8N2G7 Q8NHG9 Q9NTG8
Alternative splicing: 3 isoforms:  Q9NSY1-1   Q9NSY1-2   Q9NSY1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BMP2K: NX_Q9NSY1

Explore proteomics data for BMP2K at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for BMP2K (Q9NSY1) (see all 9)
     DNFSKLT  VWEVLILM  FTIPDNSRYS  DIWALGCLLYKL 


    See BMP2K Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_060063.2  NP_942595.1  

    ENSEMBL proteins: 
     ENSP00000373662   ENSP00000421768   ENSP00000424668   ENSP00000334836  

    BMP2K Human Recombinant Protein Products:

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    Novus Biologicals BMP2K Proteins
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BMP2K

     
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    antibodies-online proteins for BMP2K (3 products) 

     
    antibodies-online peptides for BMP2K

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: BMP2 inducible kinase
    Numb-associated kinase (NAK) family

    4 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR028182 BMP2K_C

    Graphical View of Domain Structure for InterPro Entry Q9NSY1

    ProtoNet protein and cluster: Q9NSY1

    UniProtKB/Swiss-Prot: BMP2K_HUMAN, Q9NSY1
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with BMP2K           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP2K_HUMAN, Q9NSY1
    Function: May be involved in osteoblast differentiation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with BMP2K           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for BMP2K:
     Decreased substrate adherent c  Decreased telomerase activity  Increased TP53 protein express 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for BMP2K

    miRNA
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    miRTarBase miRNAs that target BMP2K:
    hsa-let-7e-5p (MIRT051629), hsa-mir-192-5p (MIRT026511), hsa-mir-98-5p (MIRT027518)

    Block miRNA regulation of human, mouse, rat BMP2K using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate BMP2K:
    hsa-miR-186 hsa-miR-3143 hsa-miR-105
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BMP2K_HUMAN, Q9NSY1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with BMP2K           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BMP2K About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with BMP2K           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for BMP2K):
        Transcriptional misregulation in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BMP2K
    Interactions:

        Search GeneGlobe Interaction Network for BMP2K

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BMP2K (Q9NSY13 ENSP000003348364) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MBPP026863, ENSP000003482734I2D: score=1 STRING: ENSP00000348273
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
    EPS15P425663, ENSP000003607984I2D: score=1 STRING: ENSP00000360798
    KDM5BQ9UGL13, ENSP000003562344I2D: score=1 STRING: ENSP00000356234
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0030500regulation of bone mineralization IEA--

    Find genes that share ontologies with BMP2K           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BMP2K

    2 HMDB Compounds for BMP2K    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BMP2K gene (2 alternative transcripts): 
    NM_017593.3  NM_198892.1  

    Unigene Cluster for BMP2K:

    BMP2 inducible kinase
    Hs.146551  [show with all ESTs]
    Unigene Representative Sequence: BX641162
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389010(uc010ijl.1) ENST00000502871(uc003hlj.3) ENST00000505725
    ENST00000515075 ENST00000502613 ENST00000507670(uc003hll.3) ENST00000335016(uc003hlk.3)

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate BMP2K:
    hsa-miR-186 hsa-miR-3143 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidBMP2K 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat BMP2K

    Additional mRNA sequence: 

    AB015331.1 AK021725.1 AK075278.1 AK094144.1 AK292147.1 AL137275.1 AL137661.1 BC036021.1 
    BX641162.1 

    10 DOTS entries:

    DT.310672  DT.100746794  DT.121256274  DT.121256245  DT.86839226  DT.70100355  DT.121256227  DT.75183646 
    DT.92047207  DT.97826435 

    Selected AceView cDNA sequences (see all 130):

    AW576517 AI800989 AA343337 AI369612 BX641162 N66975 NM_017593 BM477048 
    BM969332 AW300795 AK075278 AI613477 AI939552 BM710805 BI771851 BQ007819 
    AA491060 BX104243 AK094144 AI521072 AW070638 CR608097 AA490949 AI472106 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BMP2K    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                      -           -                                   -                                       
    SP2:                                                  -           -                                                               
    SP3:                                                                                                                              
    SP4:                                                              -                                                               


    ECgene alternative splicing isoforms for BMP2K

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BMP2K expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGGGGTT
    BMP2K Expression
    About this image


    BMP2K expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    BMP2K Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BMP2K Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146551
        Custom PCR Arrays for BMP2K
    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for BMP2K gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp2k1 , 5 BMP2 inducible kinase1, 5 83.6(n)1
    83.13(a)1
      5 (47.29 cM)5
    1407801  NM_080708.11  NP_542439.11 
     969976895 
    chicken
    (Gallus gallus)
    Aves BMP2K1 BMP2 inducible kinase 80.02(n)
    87.56(a)
      422578  XM_420537.4  XP_420537.2 
    lizard
    (Anolis carolinensis)
    Reptilia BMP2K6
    BMP2 inducible kinase
    68(a)
    1 ↔ 1
    5(145419936-145454114)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.93352 Xenopus laevis transcribed sequence with weak similarity more 78.77(n)    BJ097576.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bmp2k1 BMP2 inducible kinase 68.33(n)
    72.45(a)
      494101  NM_001193540.1  NP_001180469.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nak6
    Numb-associated kinase
    20(a)
    1 → many
    2L(18957900-18968721)
    worm
    (Caenorhabditis elegans)
    Secernentea sel-56
    Protein SEL-5, isoform a
    17(a)
    many ↔ many
    III(4571753-4578437) WBGene00004762
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARK16
    PRK16
    (see all 3)
    Serine/threonine protein kinase involved in regula...
    Protein serine/threonine kinase; regulates the org...
    (see all 3)
    22(a)
    19(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XIV(595623-597539) YNL020C
    IX(183937-186369) YIL095W


    ENSEMBL Gene Tree for BMP2K (if available)
    TreeFam Gene Tree for BMP2K (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BMP2K gene
    AAK12  
    5 SIMAP similar genes for BMP2K using alignment to 4 protein entries:     BMP2K_HUMAN (see all proteins):
    BMP2KL    AAK1    GAK    DKFZp564L2416    NUAK1

    Find genes that share paralogs with BMP2K           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for BMP2K
    PGOHUM00000262171


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BMP2K (see all 2512)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0403884
    A lung squamous cell carcinoma sample4--see VAR_0403882 V M mis40--------
    rs623107931,2
    C--79695583(+) TGTTTG/TTCTGA 2 -- us2k13Minor allele frequency- T:0.21CSA WA EA 240
    rs1146781421,2
    F--79695594(+) CTCCAG/ATTTTG 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1420728571,2
    --79695728(+) CCCAA-/CCTGCC 2 -- us2k10--------
    rs728612981,2
    C,F--79695930(+) AAGTTC/TAAAGT 2 -- us2k12Minor allele frequency- T:0.02WA 120
    rs1843009841,2
    --79695959(+) TCTAAC/TGTTTC 2 -- us2k10--------
    rs1889951761,2
    --79695970(+) TACCCA/GTTATC 2 -- us2k10--------
    rs1115808741,2
    C,F--79695974(+) CGTTAC/TCTCAT 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1496006651,2
    --79696139(+) TCTTAA/GGAAAC 2 -- us2k10--------
    rs1864153101,2
    --79696200(+) GGCTGC/GAGCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BMP2K (79697496 - 79837526 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for BMP2K:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727859CNV Deletion23290073
    esv990407CNV Insertion20482838
    esv272040CNV Insertion20981092
    nsv879504CNV Loss21882294
    esv26247CNV Loss19812545
    nsv508291CNV Loss20534489
    nsv822627CNV Loss20364138
    nsv829979CNV Gain17160897

    Human Gene Mutation Database (HGMD): BMP2K
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BMP2K
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP2K

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with BMP2K           About GenesLikeMe

    Genetic Association Database (GAD): BMP2K
    Human Genome Epidemiology (HuGE) Navigator: BMP2K (3 documents)

    Export disorders for BMP2K gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BMP2K gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with BMP2K)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel genetic variant of BMP2K contributes to high myopia. (PubMed id 19927351)1, 4, 9 Liu H.P....Tsai F.J. (J. Clin. Lab. Anal. 2009)
    2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)1, 2 Ueki N.... Muramatsu M.-A. (Nat. Biotechnol. 1998)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (PLoS ONE 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55589 HGNC: 18041 AceView: BMP2K Ensembl:ENSG00000138756 euGenes: HUgn55589
    ECgene: BMP2K Kegg: 55589 H-InvDB: BMP2K

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BMP2K Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BMP2K gene:
    Search GeneIP for patents involving BMP2K

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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