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Aliases for BMP2K Gene

Aliases for BMP2K Gene

  • BMP2 Inducible Kinase 2 3
  • EC 4 63
  • BIKE 3 4
  • BMP-2-Inducible Protein Kinase 3
  • HRIHFB2017 3

External Ids for BMP2K Gene

Previous GeneCards Identifiers for BMP2K Gene

  • GC04P080090
  • GC04P080155
  • GC04P080054
  • GC04P079916
  • GC04P079697
  • GC04P075443

Summaries for BMP2K Gene

Entrez Gene Summary for BMP2K Gene

  • This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BMP2K Gene

BMP2K (BMP2 Inducible Kinase) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include protein serine/threonine kinase activity and phosphatase regulator activity. An important paralog of this gene is AAK1.

UniProtKB/Swiss-Prot for BMP2K Gene

  • May be involved in osteoblast differentiation

Gene Wiki entry for BMP2K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP2K Gene

Genomics for BMP2K Gene

Regulatory Elements for BMP2K Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BMP2K Gene

78,776,342 bp from pter
78,916,372 bp from pter
140,031 bases
Plus strand

Genomic View for BMP2K Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMP2K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP2K Gene

Proteins for BMP2K Gene

  • Protein details for BMP2K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BMP-2-inducible protein kinase
    Protein Accession:
    Secondary Accessions:
    • O94791
    • Q4W5H2
    • Q8IYF2
    • Q8N2G7
    • Q8NHG9
    • Q9NTG8

    Protein attributes for BMP2K Gene

    1161 amino acids
    Molecular mass:
    129172 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for BMP2K Gene

    Alternative splice isoforms for BMP2K Gene


neXtProt entry for BMP2K Gene

Proteomics data for BMP2K Gene at MOPED

Post-translational modifications for BMP2K Gene

Other Protein References for BMP2K Gene

Antibody Products

Domains for BMP2K Gene

Gene Families for BMP2K Gene

Protein Domains for BMP2K Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NSY1
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with BMP2K: view

Function for BMP2K Gene

Molecular function for BMP2K Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
May be involved in osteoblast differentiation

Enzyme Numbers (IUBMB) for BMP2K Gene

Gene Ontology (GO) - Molecular Function for BMP2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with BMP2K: view
genes like me logo Genes that share phenotypes with BMP2K: view

Animal Model Products

miRNA for BMP2K Gene

miRTarBase miRNAs that target BMP2K

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMP2K

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for BMP2K Gene

Localization for BMP2K Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP2K Gene

Subcellular locations from

Jensen Localization Image for BMP2K Gene COMPARTMENTS Subcellular localization image for BMP2K gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for BMP2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with BMP2K: view

Pathways for BMP2K Gene

genes like me logo Genes that share pathways with BMP2K: view

Pathways by source for BMP2K Gene

1 KEGG pathway for BMP2K Gene

Gene Ontology (GO) - Biological Process for BMP2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0030500 regulation of bone mineralization IEA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with BMP2K: view

Compounds for BMP2K Gene

(2) HMDB Compounds for BMP2K Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
genes like me logo Genes that share compounds with BMP2K: view

Transcripts for BMP2K Gene

Unigene Clusters for BMP2K Gene

BMP2 inducible kinase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMP2K

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BMP2K Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - -
SP4: -

Relevant External Links for BMP2K Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BMP2K Gene

mRNA expression in normal human tissues for BMP2K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for BMP2K Gene

This gene is overexpressed in Brain (41.3) and Serum (13.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BMP2K Gene

SOURCE GeneReport for Unigene cluster for BMP2K Gene Hs.146551

genes like me logo Genes that share expressions with BMP2K: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for BMP2K Gene

Orthologs for BMP2K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BMP2K Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BMP2K 35
  • 86.01 (n)
  • 87.11 (a)
BMP2K 36
  • 80 (a)
(Canis familiaris)
Mammalia BMP2K 35
  • 90.76 (n)
  • 90.03 (a)
BMP2K 36
  • 89 (a)
(Mus musculus)
Mammalia Bmp2k 35
  • 83.6 (n)
  • 83.13 (a)
Bmp2k 16
Bmp2k 36
  • 82 (a)
(Pan troglodytes)
Mammalia BMP2K 35
  • 99.31 (n)
  • 99.57 (a)
BMP2K 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Bmp2k 35
  • 83.22 (n)
  • 82.33 (a)
(Monodelphis domestica)
Mammalia BMP2K 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia BMP2K 36
  • 71 (a)
(Gallus gallus)
Aves BMP2K 35
  • 80.02 (n)
  • 87.56 (a)
BMP2K 36
  • 72 (a)
(Anolis carolinensis)
Reptilia BMP2K 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp2k 35
  • 68.64 (n)
  • 67.64 (a)
Str.14011 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.9335 35
(Danio rerio)
Actinopterygii bmp2k 35
  • 68.33 (n)
  • 72.45 (a)
bmp2k 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nak 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea sel-5 36
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AKL1 36
  • 15 (a)
ARK1 36
  • 22 (a)
PRK1 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for BMP2K:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP2K Gene

Gene Tree for BMP2K (if available)
Gene Tree for BMP2K (if available)

Paralogs for BMP2K Gene

Paralogs for BMP2K Gene

Selected SIMAP similar genes for BMP2K Gene using alignment to 4 proteins: Pseudogenes for BMP2K Gene

genes like me logo Genes that share paralogs with BMP2K: view

Variants for BMP2K Gene

Sequence variations from dbSNP and Humsavar for BMP2K Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs14629 -- 78,879,189(-) AACAT(C/T)AATTT utr-variant-3-prime, intron-variant
rs890303 -- 78,775,445(-) TAAGG(C/T)CGTTT upstream-variant-2KB
rs976926 -- 78,775,324(-) TGGCC(A/C)CCCTG upstream-variant-2KB
rs1061400 -- 78,872,553(-) GCACT(G/T)CATCT intron-variant
rs1426138 -- 78,780,374(-) GCCTC(C/T)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BMP2K Gene

Variant ID Type Subtype PubMed ID
esv2727859 CNV Deletion 23290073
esv26247 CNV Loss 19812545
nsv879504 CNV Loss 21882294
nsv508291 CNV Loss 20534489
esv990407 CNV Insertion 20482838
nsv829979 CNV Gain 17160897
esv272040 CNV Insertion 20981092
nsv822627 CNV Loss 20364138

Relevant External Links for BMP2K Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMP2K Gene

Disorders for BMP2K Gene

Relevant External Links for BMP2K

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for BMP2K Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for BMP2K Gene

Publications for BMP2K Gene

  1. A novel genetic variant of BMP2K contributes to high myopia. (PMID: 19927351) Liu H.P. … Tsai F.J. (J. Clin. Lab. Anal. 2009) 3 23 48
  2. Selection system for genes encoding nuclear-targeted proteins. (PMID: 9853615) Ueki N. … Muramatsu M.-A. (Nat. Biotechnol. 1998) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48

Products for BMP2K Gene

  • Addgene plasmids for BMP2K

Sources for BMP2K Gene

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