BMP2K Gene
protein-coding GIFtS: 54
GCID: GC04P079697
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BMP2 inducible kinase
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Aliases for BMP2K gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| BMP2 Inducible Kinase1 2 | | BIKe1 3 | | BIKE2 3 | | EC 2.7.11.13 8 | | DKFZp434K06141 | | BMP-2-Inducible Protein Kinase2 |
Export aliases for BMP2K gene to outside databasesPrevious GC identifers: GC04P080090 GC04P080155 GC04P080054 GC04P079916 GC04P075443 |
Summaries for BMP2K gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for BMP2K: This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role inskeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiationand the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal.Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory rolein attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms havebeen found for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: BMP2K_HUMAN, Q9NSY1Function: May be involved in osteoblast differentiation Gene Wiki entry for BMP2K
|
Genomic Views for BMP2K gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the BMP2K gene promoter: Oct-B1 HFH-3 Max1 FOXI1 S8 c-Myc En-1 ATF6 Other transcription factors
Search SABiosciences Chromatin IP Primers for BMP2K
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP2K |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q21.21 Ensembl cytogenetic band: 4q21.21 HGNC cytogenetic band: 4q21.21BMP2K Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P079697: view genomic region
(about GC identifiers)
Start:
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79,697,496 bp from pter |
End:
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79,837,526 bp from pter |
Size:
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140,031 bases |
Orientation:
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plus strand |
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Proteins for BMP2K gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: BMP2K_HUMAN, Q9NSY1 (See
protein sequence)Recommended Name: BMP-2-inducible protein kinase Size: 1161 amino acids; 129172 Da
Subcellular location: Nucleus
Secondary accessions: O94791 Q8IYF2 Q8N2G7 Q8NHG9 Q9NTG8Alternative splicing: 3 isoforms: Q9NSY1-1 Q9NSY1-2 Q9NSY1-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for BMP2K: NX_Q9NSY1
Post-translational modifications:
Autophosphorylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NSY1 4/9 DME Specific Peptides for BMP2K (Q9NSY1) (see all 9)
BMP2K Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_060063.2 NP_942595.1 ENSEMBL proteins: ENSP00000373662 ENSP00000421768 ENSP00000424668 ENSP00000334836 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
BMP2K for ontologies About GeneDecksing
BMP2K Antibody Products: Assay Products for BMP2K: |
Protein
Domains / Families for BMP2K gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BMP2K for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NSY1ProtoNet protein and cluster: Q9NSY1 UniProtKB/Swiss-Prot: BMP2K_HUMAN, Q9NSY1Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function for BMP2K gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: BMP2K_HUMAN, Q9NSY1Function: May be involved in osteoblast differentiationCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.11 2
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMP2K (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMP2K (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): BMP2K (NM_017593) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BMP2K | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP2K  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP2K |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004672 | protein kinase activity |
-- | -- | | GO:0004674 | protein serine/threonine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0019208 | phosphatase regulator activity |
IEA | -- |
BMP2K for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for BMP2K:
|
Pathways & Interactions for BMP2K gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BMP2K
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
 5/8 Interacting proteins for BMP2K (Q9NSY13 ENSP000003348364) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein phosphorylation |
-- | -- | | GO:0030500 | regulation of bone mineralization |
IEA | -- |
BMP2K for ontologies About GeneDecksing
|
Drugs & Compounds for BMP2K gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for BMP2K
2 HMDB Compounds for BMP2K About this table Search CenterWatch for drugs/clinical trials and news about BMP2K 
|
Transcripts for BMP2K gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for BMP2K gene (2 alternative transcripts): NM_017593.3 NM_198892.1 Unigene Cluster for BMP2K: BMP2 inducible kinase Hs.146551 [show with all ESTs]Unigene Representative Sequence: BX6411627 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389010(uc010ijl.1) ENST00000502871(uc003hlj.3) ENST00000505725 ENST00000515075 ENST00000502613 ENST00000507670(uc003hll.3) ENST00000335016(uc003hlk.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BMP2K (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BMP2K (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): BMP2K (NM_017593) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BMP2K | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP2K  |
Additional cDNA sequence: AB015331.1 AK021725.1 AK075278.1 AK094144.1 AK292147.1 AL137275.1 AL137661.1 BC036021.1 BX641162.1 10 DOTS entries: DT.310672 DT.100746794 DT.121256274 DT.121256245 DT.86839226 DT.70100355 DT.121256227 DT.75183646 DT.92047207 DT.97826435 24/130 AceView cDNA sequences (see all 130): AL137661 AA491136 AA343337 BM477048 AA490949 AI800989 BM710805 AI369613 AA491060 BX104243 AL137275 AA926798 AK075278 AW300795 AI939552 BG776990 AI472106 AW070638 BX641162 BM667636 AB015331 AK094144 CA446589 NM_017593 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for BMP2K About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for BMP2K
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Expression for BMP2K gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BMP2K expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ATTTGGGGTT
About this image See BMP2K Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for BMP2K
SOURCE GeneReport for Unigene cluster: Hs.146551 SABiosciences Custom PCR Arrays for BMP2K
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BMP2K Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BMP2K | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP2K | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP2K | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP2K |
Orthologs for BMP2K gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BMP2K gene from 7/24 species (see all 24) About this table
ENSEMBL Gene Tree for BMP2K (if available) TreeFam Gene Tree for BMP2K (if available)  |
Paralogs for BMP2K gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for BMP2K gene
- AAK12
5 SIMAP similar genes for BMP2K using alignment to 4 protein entries: BMP2K_HUMAN (see all proteins):BMP2KL AAK1 GAK DKFZp564L2416 NUAK1
BMP2K for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for BMP2K PGOHUM00000262171
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Genomic Variants for BMP2K gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for BMP2K 1 Indel: 68755 Human Gene Mutation Database (HGMD): BMP2K
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BMP2K |
|
Disorders
/ Diseases for BMP2K gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BMP2K for disorders About GeneDecksing
9 diseases for BMP2K: About MalaCardsinternuclear ophthalmoplegia vaginal discharge ulnar neuropathy ophthalmoplegia myopia neuropathy vaginitis osteoporosis malaria Human Genome Epidemiology (HuGE) Navigator: BMP2K (3 documents) Export disorders for BMP2K gene to outside databases
|
Publications for BMP2K gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BMP2K gene, integrated from 9 sources (see all 25): (articles sorted by number of sources associating them with BMP2K) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)1, 2 Ueki N.... Muramatsu M.-A. (1998)
- A novel genetic variant of BMP2K contributes to high myopia. (PubMed id 19927351)1, 9 Liu H.P....Tsai F.J. (2009)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
- The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor. (PubMed id 19336002)1 Zhou W....Zhang L. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for BMP2K gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing BMP2K gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BMP2K gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BMP2K gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for BMP2K | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BMP2K gene: Search GeneIP for patents involving BMP2K
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for BMP2K gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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variant library, vector shuttling | | OriGene Custom Antibody Services for BMP2K | | OriGene Custom Protein Services for BMP2K | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BMP2K | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BMP2K | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP2K | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP2K | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP2K | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP2K |
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| | | Search Tocris compounds for BMP2K |
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 | | BMP2K Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP2K |
|  |  |  | | | ThermoFisher Antibodies for BMP2K |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP2K |
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