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BMP2 Gene

protein-coding   GIFtS: 72
GCID: GC20P006696

Bone Morphogenetic Protein 2


(Previous symbol: BMP2A)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bone Morphogenetic Protein 21 2
BMP2A1 2 3 5
Bone Morphogenetic Protein 2A2 3
BMP-2A2 3
BDA22 5
BMP-23

External Ids:    HGNC: 10691   Entrez Gene: 6502   Ensembl: ENSG000001258457   OMIM: 1122615   UniProtKB: P126433   

Export aliases for BMP2 gene to outside databases

Previous GC identifers: GC20P006737 GC20P006744


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BMP2 Gene:
The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded
protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. (provided by RefSeq, Jul
2008)

GeneCards Summary for BMP2 Gene:
BMP2 (bone morphogenetic protein 2) is a protein-coding gene. Diseases associated with BMP2 include trigeminal neuralgia, and tympanosclerosis. GO annotations related to this gene include cytokine activity and protein heterodimerization activity. An important paralog of this gene is GDF5.

UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643
Function: Induces cartilage and bone formation

Gene Wiki entry for BMP2 (Bone morphogenetic protein 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the BMP2 gene promoter:
         MEF-2A   AML1a   aMEF-2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP2 promoter sequence
   Search Chromatin IP Primers for BMP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p12

BMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P006696:  view genomic region     (about GC identifiers)

Start:
6,748,311 bp from pter      End:
6,760,927 bp from pter
Size:
12,617 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643 (See protein sequence)
Recommended Name: Bone morphogenetic protein 2 precursor  
Size: 396 amino acids; 44702 Da
Subunit: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts
with ASPN (By similarity)
Selected PDB 3D structures from and Proteopedia for BMP2 (see all 12):
1ES7 (3D)        1REU (3D)        1REW (3D)        2GOO (3D)        2H62 (3D)        2H64 (3D)    

Explore the universe of human proteins at neXtProt for BMP2: NX_P12643

Explore proteomics data for BMP2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn135, Asn163, Asn164, Asn200, Asn338
  • Modification sites at PhosphoSitePlus

  • See BMP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001191.1  
    ENSEMBL proteins: 
     ENSP00000368104  
    Reactome Protein details: P12643

    BMP2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant BMP2 Protein
    R&D Systems Recombinant & Natural Proteins for BMP2 (BMP-2, BMP-2/BMP-6 Heterodimer, BMP-2/BMP-7 Heterodimer)
    Enzo Life Sciences proteins for BMP2
    OriGene Purified Proteins for BMP2
    OriGene Protein Over-expression Lysate for BMP2
    OriGene MassSpec for BMP2
    OriGene Custom Protein Services for BMP2
    GenScript Purified and Recombinant Proteins for BMP2
    Novus Biologicals BMP2 Proteins
    Novus Biologicals BMP2 Lysates
    Sino Biological Recombinant Protein for BMP2
    Sino Biological Cell Lysate for BMP2
    ProSpec Recombinant Protein for BMP2
    Cloud-Clone Corp. Proteins for BMP2

    BMP2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BMP2
    R&D Systems Antibodies for BMP2 (BMP-2, BMP-2/BMP-4, BMP-2/BMP-7 Heterodimer)
    OriGene Antibodies for BMP2
    OriGene Custom Antibody Services for BMP2
    Novus Biologicals BMP2 Antibodies
    Abcam antibodies for BMP2 (P12643, P12644)
    Cloud-Clone Corp. Antibodies for BMP2
    ThermoFisher Antibodies for BMP2
    LSBio Antibodies in human, mouse, rat for BMP2

    BMP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BMP2
    R&D Systems ELISAs for BMP2 (BMP-2)         (see all)
    GenScript Custom Assay Services for BMP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BMP2
    Cloud-Clone Corp. CLIAs for BMP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    BMP: Bone morphogenetic proteins

    5 InterPro protein domains:
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR002405 Inhibin_asu
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P12643

    ProtoNet protein and cluster: P12643

    2 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)


    UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643
    Similarity: Belongs to the TGF-beta family


    BMP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP2_HUMAN, P12643
    Function: Induces cartilage and bone formation

         Genatlas biochemistry entry for BMP2:
    bone morphogenetic protein 2 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),regulating
    myogenesis through dosage-dependent PAX3 expression in pre-myogenic cells,expressed in mesoderm under SHM control
    throuhg the mediaton of SOX9,involved in bone formation

         Summary: 
    During embryonic development, BMP2 as signaling molecule is secreted from the following cells:
          selected tissues (see all 5)      fully expand
    Bone: Endochondral Osteoblasts (Rostral Endochondral Facial Bones), Hypertrophic Chondrocytes (Caudal Endochondral Bones)      fully expand to see all 10 cells
    Heart: Cardiomyocytes (Myocardium), Semilunar Valve Cells (Inner Curvature)      fully expand to see all 3 cells

    It affects the following cells:
          selected tissues (see all 10)      fully expand
    Bone: Endochondral Preosteoblasts (Stylopod Periosteum), Endochondral Osteoblasts (Rib)      fully expand to see all 34 cells
    Adipose: Preadipocytes (Facial Subcutaneous White Adipose), Subcutaneous White Preadipocytes (Cranial Subcutaneous White Adipose)      fully expand to see all 8 cells

    BMP2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 4)      fully expand
    Cartilage: Hypertrophic chondrocytes like cells, BMP2 induced Embryoid Bodies      fully expand to see all 3 cells
    Bone: Osteoblast-like cells , Osteoblast-like cells

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004745retinol dehydrogenase activity ISS--
    GO:0005102receptor binding TAS2315314
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding IPI10881198
    GO:0008083growth factor activity IEA--
         
    BMP2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for BMP2:
     Cell division defect  Decreased cell number, increas  Metaphase cells 

         14 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Bmp2):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
     nervous system  normal  reproductive system  skeleton 

    BMP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BMP2: Bmp2tm1Brd Bmp2tm1.1Jfm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BMP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BMP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BMP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BMP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target BMP2:
    hsa-mir-335-5p (MIRT017583), hsa-mir-26b-5p (MIRT029250)

    Block miRNA regulation of human, mouse, rat BMP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMP2 (see all 50):
    hsa-miR-4291 hsa-miR-140-5p hsa-miR-142-5p hsa-miR-607 hsa-miR-106a hsa-miR-374a hsa-miR-759 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidBMP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BMP2
    Predesigned siRNA for gene silencing in human, mouse, rat BMP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BMP2

    Clone
    Products:
         
    OriGene clones in human, mouse for BMP2 (see all 6)
    OriGene ORF clones in mouse, rat for BMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP2 (NM_001200)
    Sino Biological Human cDNA Clone for BMP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BMP2
    ESI BIO PureStem Progenitors for BMP2: 
    PureStem MEL2, NCr-fac Progenitor, PureStem Z11, Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BMP2_HUMAN, P12643: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytoskeleton2
    nucleus2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0009986cell surface IDA--

    BMP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BMP2 About   (see all 32)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Signaling by BMP
    Signaling by BMP0.35
    BMP signalling and regulation0.35
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BMP2 (see all 74)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    Selected BioSystems Pathways for BMP2 (see all 6)
        Heart Development
    Senescence and Autophagy
    Adipogenesis
    BMP signalling and regulation
    BDNF signaling pathway

    1 Sino Biological Pathway for BMP2
        TGF-beta Signaling Pathway

    2 Reactome Pathways for BMP2
        Molecules associated with elastic fibres
    Signaling by BMP


    Selected Kegg Pathways  (Kegg details for BMP2) (see all 6):
        Cytokine-cytokine receptor interaction
    Hedgehog signaling pathway
    TGF-beta signaling pathway
    Hippo signaling pathway
    Pathways in cancer


    BMP2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMP2 (see all 16): 
              Osteogenesis in human mouse rat
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BMP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BMP2 (P126431, 2, 3 ENSP000003681044) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR1AP368941, 2, 3EBI-1029262,EBI-1029237 MINT-7261613 MINT-7261693 MINT-7261751 MINT-7990950 MINT-7261681 MINT-7261597 MINT-7261806 MINT-7261817 MINT-7261794 MINT-7261846 MINT-8044230 I2D: score=5 
    DIP2AQ146892, 3, ENSP000003920664MINT-7991072 I2D: score=1 STRING: ENSP00000392066
    BMPR1BO002381, 2, 3, ENSP000002645684EBI-1029262,EBI-7527193 MINT-7264575 MINT-7264562 MINT-7264587 I2D: score=3 STRING: ENSP00000264568
    NOGQ132531, 2, 3, ENSP000003281814EBI-1029262,EBI-1035205 MINT-7261628 MINT-7261642 I2D: score=2 STRING: ENSP00000328181
    FSTL1Q128411, 2, 3, ENSP000002956334EBI-1029262,EBI-2349801 MINT-7990960 MINT-7990865 I2D: score=1 STRING: ENSP00000295633
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 88):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA19736317
    GO:0000187activation of MAPK activity IDA17202865
    GO:0001501skeletal system development TAS2315314
    GO:0001649osteoblast differentiation IDA15150273
    GO:0001658branching involved in ureteric bud morphogenesis ISS--

    BMP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BMP2

    UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643
    Pharmaceutical: Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft
    fractures

    1 HMDB Compound for BMP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    Selected Novoseek inferred chemical compound relationships for BMP2 gene (see all 101)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alizarin 72.7 11 17236579 (1), 20395805 (1), 17300917 (1), 19146860 (1) (see all 10)
    hydroxyapatite 68.8 108 10853181 (4), 17189469 (3), 17617550 (3), 10512384 (2) (see all 50)
    atelocollagen 63.8 6 9565272 (2), 11168221 (1), 18404714 (1), 11502864 (1)
    titanium 60 58 17618492 (4), 19216269 (3), 19767180 (2), 16683108 (2) (see all 27)
    alizarin red s 59.6 1 15105665 (1)
    poly-p-dioxanone 57.7 3 16564087 (2), 16479565 (1)
    poly(dl-lactide-co-glycolide) 53.9 13 9552326 (2), 10357135 (1), 9584385 (1), 10679684 (1) (see all 7)
    dexamethasone 51.9 108 15183687 (9), 17512555 (6), 12854828 (4), 18404732 (3) (see all 51)
    poly-d 51.4 2 11936403 (1), 9592717 (1)
    alginate 45.3 18 17321862 (4), 15219571 (3), 18950289 (3), 16649180 (2) (see all 7)



    BMP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for BMP2 gene: 
    NM_001200.2  

    Unigene Cluster for BMP2:

    Bone morphogenetic protein 2
    Hs.73853  [show with all ESTs]
    Unigene Representative Sequence: NM_001200
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000378827(uc002wmu.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BMP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BMP2 (see all 50):
    hsa-miR-4291 hsa-miR-140-5p hsa-miR-142-5p hsa-miR-607 hsa-miR-106a hsa-miR-374a hsa-miR-759 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidBMP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BMP2
    Predesigned siRNA for gene silencing in human, mouse, rat BMP2
    Clone
    Products:
         
    OriGene clones in human, mouse for BMP2 (see all 6)
    OriGene ORF clones in mouse, rat for BMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP2 (NM_001200)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BMP2
    OriGene qSTAR qPCR primer pairs in human, mouse for BMP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BMP2
      QuantiTect SYBR Green Assays in human, mouse, rat BMP2
      QuantiFast Probe-based Assays in human, mouse, rat BMP2

    Additional mRNA sequence: 

    BC069214.1 M22489.1 

    2 DOTS entries:

    DT.113271  DT.100813580 

    Selected AceView cDNA sequences (see all 84):

    AA488371 AI379163 AA630607 BM683313 M22489 CB163046 NM_001200 BM670141 
    BQ003843 BC069214 BX101090 CB132019 CR618407 AA583044 BQ890465 BU625617 
    AA181547 AA010702 BM993226 BF437206 BM670241 AI084926 AA489383 BQ186599 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BMP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGTGGAGG
    BMP2 Expression
    About this image


    BMP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 30) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 19 entries
             Endochondral Osteoblasts Rostral Endochondral Facial Bones
             Mandibular Process
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Kidney (Urinary System)    fully expand to see all 11 entries
             Distal Renal Vesicle Cells Renal Vesicle
             S-shaped Body
     
     Tooth (Integumentary System)    fully expand to see all 11 entries
             Odontoblasts Dentin
             Dentin
             Stem cells from human exfoliated deciduous teeth (family)
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Epithelial Cells
             Intermediate Keratinocytes Embryonic Epidermis
    BMP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BMP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73853

    UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643
    Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart,
    brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BMP2 (see all 16): 
              Osteogenesis in human mouse rat
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BMP2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp21 , 5 bone morphogenetic protein 21, 5 87.31(n)1
    92.39(a)1
      2 (65.21 cM)5
    121561  NM_007553.31  NP_031579.21 
     1335521595 
    chicken
    (Gallus gallus)
    Aves BMP21 bone morphogenetic protein 2 79.37(n)
    81.33(a)
      378779  NM_204358.1  NP_989689.1 
    lizard
    (Anolis carolinensis)
    Reptilia BMP26
    bone morphogenetic protein 2
    76(a)
    1 ↔ 1
    1(136433007-136452699)
    African clawed frog
    (Xenopus laevis)
    Amphibia X63424.12   -- 76.16(n)    X63424.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_131359.12   -- 72.92(n)   30631  NM_131359.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dpp1 , 3 TGFbeta receptor signaling pathway
    transforming growth factor-beta
    receptor ligand less3
    decapentaplegic1
    40(a)3
    50.09(n)1
    42.55(a)1
      334321  NM_057963.51  NP_477311.11 


    ENSEMBL Gene Tree for BMP2 (if available)
    TreeFam Gene Tree for BMP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BMP2 gene
    GDF52  BMP52  GDF32  BMP8B2  GDF62  BMP42  GDF72  GDF22  
    BMP102  BMP72  GDF12  BMP8A2  BMP62  
    17 SIMAP similar genes for BMP2 using alignment to 11 protein entries:     BMP2_HUMAN (see all proteins):
    GDF6    gdf7    BMP4    NODAL    BMP3    TGFB1
    DKFZp686A06204    GDF5    INHA    BMPY    BMP8A    GDF8
    BMP6    BMP7    GDF3    GDF3A    BMP10

    BMP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BMP2 (see all 301)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423288701,2
    --6694057(+) CTCCCC/TTACCG 1 -- us2k10--------
    rs603087361,2
    C--6694114(+) CTGACT/CTTTTT 1 -- us2k13Minor allele frequency- C:0.06NA WA 240
    rs753287341,2
    C,F--6694256(+) GAAGGG/ACAGAA 1 -- us2k13Minor allele frequency- A:0.15CSA WA 122
    rs1446364161,2
    --6694273(+) GGCCCC/GAGACT 1 -- us2k10--------
    rs1820435631,2
    --6694479(+) CTCTGA/GGCTGC 1 -- us2k10--------
    rs1458408811,2
    --6694490(+) TAATCA/GCCTGC 1 -- us2k10--------
    rs749797661,2
    C,F--6694505(+) GAGCTG/AGGTGA 1 -- us2k12Minor allele frequency- A:0.10WA EA 238
    rs1490056861,2
    --6694568(+) CCCATC/GCATCC 1 -- us2k10--------
    rs61078691,2
    C,F,H--6694605(+) GTTACA/GCACAT 1 -- us2k119Minor allele frequency- G:0.05NS EA NA 2078
    rs19798551,2
    C,F,A,H--6694657(-) TCGGTT/CAATAT 1 -- us2k128Minor allele frequency- C:0.20NS EA NA WA 3132

    HapMap Linkage Disequilibrium report for BMP2 (6748311 - 6760927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BMP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833910CNV Gain17160897

    Human Gene Mutation Database (HGMD): BMP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BMP2
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 112261   
    OMIM disorders: 235200  112600  
    Selected diseases for BMP2 (see all 129):    
    About MalaCards
    trigeminal neuralgia    tympanosclerosis    hfe hemochromatosis, modifier of    20p12.3 microdeletion syndrome
    keutel syndrome    avascular necrosis of the femoral head    brachydactyly type a2    fibrodysplasia ossificans progressiva
    lumbar disc disease    hfe-associated hereditary hemochromatosis    osteochondroma    osteosclerosis
    hyperphosphatemia    juvenile polyposis syndrome    osteomyelitis    spondylolisthesis
    wolff-parkinson-white syndrome    renal dysplasia    ankylosis    bone fracture

    9 diseases from the University of Copenhagen DISEASES database for BMP2:
    Osteoporosis     Ankylosis     Degenerative disc disease     Osteonecrosis
    Spondylolisthesis     Root resorption     Osteoarthritis     Cancer
    Radiculopathy

    BMP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for BMP2 gene (see all 90)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcification 66.7 84 18179800 (5), 20307738 (5), 14587031 (4), 16037577 (3) (see all 39)
    arthrodesis 64.7 30 19411467 (3), 19487515 (2), 15966907 (2), 19571082 (2) (see all 22)
    ossification heterotopic 54.5 6 16903944 (2), 19043134 (1), 11600747 (1), 16619272 (1) (see all 5)
    osteosarcoma 53.6 30 16470222 (3), 10491221 (2), 17022972 (2), 10814523 (2) (see all 22)
    degenerative disc disease 51.6 2 17669279 (2)
    osteoporosis 51.2 28 16753015 (3), 14691541 (3), 11240412 (1), 16470007 (1) (see all 16)
    pseudarthrosis 51.1 4 19226004 (1), 19579208 (1), 20228711 (1)
    furcation defects 41.7 2 15966907 (2)
    lumbar disc disease 39.6 3 19411467 (2), 15198497 (1)
    seroma 37.7 3 20495420 (2), 18827703 (1)

    Genetic Association Database (GAD): BMP2
    Human Genome Epidemiology (HuGE) Navigator: BMP2 (44 documents)

    Export disorders for BMP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BMP2 gene, integrated from 10 sources (see all 1471):
    (articles sorted by number of sources associating them with BMP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance. (PubMed id 17847004)1, 4, 9 Milet J....Mosser J. (Am. J. Hum. Genet. 2007)
    2. BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study. (PubMed id 16753015)1, 4, 9 Medici M....Uitterlinden A.G. (J. Bone Miner. Res. 2006)
    3. Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution. (PubMed id 10074410)1, 2, 9 Scheufler C.... Huelsmeyer M. (J. Mol. Biol. 1999)
    4. Variation in the bone morphogenetic protein-2 gene: effects on fat and lean body mass in young and elderly women. (PubMed id 18426824)1, 4, 9 McGuigan F....Akesson K. (Eur. J. Endocrinol. 2008)
    5. Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily. (PubMed id 2376592)1, 3, 9 Sampath T.K....Rueger D.C. (J. Biol. Chem. 1990)
    6. Genetic heterogeneity in colorectal cancer associations between African and European americans. (PubMed id 20659471)1, 4 Kupfer S.S....Ellis N.A. (Gastroenterology 2010)
    7. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment. (PubMed id 20555025)1, 2 Heng S.... Nie G. (Endocrinology 2010)
    10. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 650 HGNC: 1069 AceView: BMP2 Ensembl:ENSG00000125845 euGenes: HUgn650
    ECgene: BMP2 Kegg: 650 H-InvDB: BMP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BMP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BMP2 gene:
    Search GeneIP for patents involving BMP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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