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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BMP2 Gene

protein-coding GIFtS: 69
GCID: GC20P006696

bone morphogenetic protein 2

(Previous symbol: BMP2A)

Explore 132 diseases affiliated with
BMP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Bone Morphogenetic Protein 2¹ ²
BMP2A¹ ² ³ ⁵
Bone Morphogenetic Protein 2A² ³
BMP-2A² ³
BDA2²
BMP-2³

External Ids:	HGNC: 1069¹	Entrez Gene: 650²	Ensembl: ENSG00000125845⁷	OMIM: 112261⁵	UniProtKB: P12643³

Export aliases for BMP2 gene to outside databases

Previous GC identifers: GC20P006737 GC20P006744

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BMP2:

The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein

acts as a disulfide-linked homodimer and induces bone and cartilage formation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643

Function: Induces cartilage and bone formation

Gene Wiki entry for BMP2 (Bone morphogenetic protein 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BMP2 gene promoter:
MEF-2A AML1a aMEF-2 Nkx2-5
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BMP2 promoter sequence

Search SABiosciences Chromatin IP Primers for BMP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20p12

BMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP2 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P006696: view genomic region (about GC identifiers)

Start:	6,748,311 bp from pter	End:	6,760,910 bp from pter
Size:	12,600 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643 (See protein sequence)

Recommended Name: Bone morphogenetic protein 2 precursor

Size: 396 amino acids; 44702 Da

Subunit: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with

ASPN (By similarity)

Subcellular location: Secreted

6/11 PDB 3D structures from and Proteopedia for BMP2 (see all 11):

1ES7 (3D)

1REU (3D)

1REW (3D)

2GOO (3D)

2H62 (3D)

2H64 (3D)

Explore the universe of human proteins at neXtProt for BMP2: NX_P12643

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P12643

BMP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001191.1

ENSEMBL proteins:

ENSP00000368104

Reactome Protein details: P12643
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant BMP2 Protein
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	Sino Biological Recombinant Protein for BMP2
	ProSpec Recombinant Protein for BMP2
	Uscn Proteins for BMP2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	--	--
GO:0009986	cell surface	IDA	--
GO:0031988	membrane-bounded vesicle	--	--

BMP2 for ontologies About GeneDecksing

BMP2 Antibody Products:

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	ThermoFisher Antibodies for BMP2

Assay Products for BMP2:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for BMP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BMP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BMP2 for domains About GeneDecksing

5 InterPro domains/families:

IPR002405 Inhibin_asu

IPR001111 TGF-b_N

IPR015615 TGF-beta-rel

IPR001839 TGF-b_C

IPR017948 TGFb_CS

Graphical View of Domain Structure for InterPro Entry P12643

ProtoNet protein and cluster: P12643

2 Blocks protein families:

IPB001111 Transforming growth factor beta (TGFb)

IPB001839 Transforming growth factor beta (TGFb)

UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643

Similarity: Belongs to the TGF-beta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643

Function: Induces cartilage and bone formation

Genatlas biochemistry entry for BMP2:

bone morphogenetic protein 2 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),regulating myogenesis

through dosage-dependent PAX3 expression in pre-myogenic cells,expressed in mesoderm under SHM control throuhg the

mediaton of SOX9,involved in bone formation

Summary:

During embryonic development, BMP2 as signaling molecule is secreted from the following cells: Apical Ectodermal Ridge Cells in Limb Ectoderm, Cardiomyocytes in Myocardium (see all 18).

It affects the following cells: Chondrocytes in Rostral Synchondroses, Chondrocytes in Synchondroses (see all 68).

BMP2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Osteoblast-like cells , BMP2 induced Embryoid Bodies (see all 4).

miRNA Products:		OriGene 3'-UTR Clone: BMP2 Browse MicroRNA Expression Plasmids
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		8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP2 (see all 50):
		hsa-miR-4291 hsa-miR-140-5p hsa-miR-142-5p hsa-miR-607 hsa-miR-106a hsa-miR-374a hsa-miR-759 hsa-miR-3921

		SwitchGear 3'UTR luciferase reporter plasmid: BMP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector: BMP2 (NM_001200)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP2

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004745	retinol dehydrogenase activity	ISS	--
GO:0005102	receptor binding	TAS	2315314
GO:0005125	cytokine activity	IEA	--
GO:0005515	protein binding	IPI	18184661
GO:0008083	growth factor activity	IEA	--

BMP2 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for BMP2:

Cell division defect

Decreased cell number, increas

Metaphase cells

Animal Models:
Mouse knock-outs for BMP2: Bmp2^tm1Brd Bmp2^tm1.1Jfm
14 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Bmp2):

cardiovascular system	cellular	craniofacial	digestive/alimentary	embryogenesis
growth/size	hearing/vestibular/ear	homeostasis/metabolism	limbs/digits/tail	mortality/aging
nervous system	normal	reproductive system	skeleton

BMP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/31 super-pathways (see all 31) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Pathway sources
See GeneCards unified pathways
Show all pathways

5/74 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BMP2 (see all 74)

	Telomerase Components in Cell Signaling
	Molecular Mechanisms of Cancer
	eIF2 Pathway
	Intracellular Calcium Signaling
	JNK Pathway

5/6 BioSystems Pathways for BMP2 (see all 6)

	Senescence and Autophagy
	Adipogenesis
	Heart Development
	BMP signalling and regulation
	BMP Signalling Pathway

5 Reactome Pathways for BMP2

	Molecules associated with elastic fibres
	Extracellular matrix organization
	Elastic fibre formation
	Signal Transduction
	Signaling by BMP

5 Kegg Pathways (Kegg details for BMP2):

	Cytokine-cytokine receptor interaction
	Hedgehog signaling pathway
	TGF-beta signaling pathway
	Pathways in cancer
	Basal cell carcinoma

BMP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BMP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for BMP2 (P12643^{1, 2, 3} ENSP00000368104⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BMPR1A	P36894¹^,²^,³, ENSP00000224764⁴	EBI-1029262,EBI-1029237 MINT-7261613 MINT-7261693 MINT-7261751 MINT-7990950 MINT-7261681 MINT-7261597 MINT-7261806 MINT-7261817 MINT-7261794 MINT-7261846 MINT-8044230 I2D: score=5 STRING: ENSP00000224764
DIP2A	Q14689²^,³, ENSP00000392066⁴	MINT-7991072 I2D: score=1 STRING: ENSP00000392066
BMPR1B	O00238²^,³, ENSP00000264568⁴	MINT-7264575 MINT-7264562 MINT-7264587 I2D: score=3 STRING: ENSP00000264568
NOG	Q13253²^,³, ENSP00000328181⁴	MINT-7261628 MINT-7261642 I2D: score=2 STRING: ENSP00000328181
FSTL1	Q12841²^,³, ENSP00000295633⁴	MINT-7990960 MINT-7990865 I2D: score=1 STRING: ENSP00000295633

About this table

Gene Ontology (GO): 5/84 biological process terms (GO ID links to tree view) (see all 84): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	19736317
GO:0001501	skeletal system development	TAS	2315314
GO:0001649	osteoblast differentiation	IDA	--
GO:0001658	branching involved in ureteric bud morphogenesis	ISS	--
GO:0001666	response to hypoxia	ISS	--

BMP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BMP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BMP2
UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643

Pharmaceutical: Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft

fractures

1 HMDB Compound for BMP2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Simvastatin	(+)-Simvastatin (see all 28)	79902-63-9	--

10/101 Novoseek chemical compound relationships for BMP2 gene (see all 101) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alizarin	72.7	11	17236579 (1), 20395805 (1), 17300917 (1), 19146860 (1) (see all 10)
hydroxyapatite	68.8	108	10853181 (4), 17189469 (3), 17617550 (3), 10512384 (2) (see all 50)
atelocollagen	63.8	6	9565272 (2), 11168221 (1), 18404714 (1), 11502864 (1)
titanium	60	58	17618492 (4), 19216269 (3), 19767180 (2), 16683108 (2) (see all 27)
alizarin red s	59.6	1	15105665 (1)
poly-p-dioxanone	57.7	3	16564087 (2), 16479565 (1)
poly(dl-lactide-co-glycolide)	53.9	13	9552326 (2), 10357135 (1), 9584385 (1), 10679684 (1) (see all 7)
dexamethasone	51.9	108	15183687 (9), 17512555 (6), 12854828 (4), 18404732 (3) (see all 51)
poly-d	51.4	2	11936403 (1), 9592717 (1)
alginate	45.3	18	17321862 (4), 15219571 (3), 18950289 (3), 16649180 (2) (see all 7)

Search CenterWatch for drugs/clinical trials and news about BMP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BMP2 gene:

NM_001200.2

Unigene Cluster for BMP2:

Bone morphogenetic protein 2

Hs.73853 [show with all ESTs]

Unigene Representative Sequence: NM_001200

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000378827(uc002wmu.1)

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		SwitchGear 3'UTR luciferase reporter plasmid: BMP2 3' UTR sequence

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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP2

Additional cDNA sequence:

BC069214.1 M22489.1

2 DOTS entries:

DT.113271 DT.100813580

24/84 AceView cDNA sequences (see all 84):

M22489 BM993226 BQ003843 AI084926 CB132019 NM_001200 AI379163 AA630607

BC069214 CB163046 BM670241 AA489383 AA010702 AA583044 BQ890465 AA181547

BF437206 BM683313 BM670141 BU625617 BX101090 AA488371 CR618407 AA489442

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BMP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTGTGGAGG

About this image

BMP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/55 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 55)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Vesicle

Distal Renal Vesicle Cells

Selective marker (cell-identifying gene)

Kidney

Limb

Limb Ectoderm

Apical Ectodermal Ridge Cells

Dermis, Ectoderm

Bone

Autopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Bone

Autopod Growth Plate

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Autopod Perichondrium

Endochondral Preosteoblasts

Bone

Caudal Endochondral Bones

Endochondral Osteoblasts

Bone

Cervical Vertebrae

Endochondral Preosteoblasts

Bone

Cervical Vertebrae

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Endochondral Facial Bones

Endochondral Osteoblasts

Bone

Lumbar Vertebrae

Endochondral Preosteoblasts

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11)

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (Generation of mesend...)

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

See BMP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BMP2

SOURCE GeneReport for Unigene cluster: Hs.73853

UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643

Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain,

placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine

SABiosciences Expression via Pathway-Focused PCR Arrays including BMP2 (see all 16):

Osteogenesis in human mouse rat

Neurogenesis in human mouse rat

Growth Factors in human mouse rat

Angiogenic Growth Factors in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BMP2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for BMP2 gene from 5/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BMP2¹	bone morphogenetic protein 2	79.37(n) 81.33(a)		378779 NM_204358.1 NP_989689.1
lizard (Anolis carolinensis)	Reptilia	C5H0M3_ANOCA⁶ --	--	83(a) 45(a)	1 ↔ 1 possible ortholog	1(136434183-136434815) LGf(3407164-3410255)
African clawed frog (Xenopus laevis)	Amphibia	X63424.1²	--	76.16(n)		X63424.1
zebrafish (Danio rerio)	Actinopterygii	NM_131359.1²	--	72.92(n)		30631 NM_131359.1
fruit fly (Drosophila melanogaster)	Insecta	dpp^{1 , 3}	TGFbeta receptor signaling pathway transforming more³ decapentaplegic¹	40(a)³ 49.82(n)¹ 42.78(a)¹		33432¹ NM_057963.4¹ NP_477311.1¹

ENSEMBL Gene Tree for BMP2 (if available)
TreeFam Gene Tree for BMP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for BMP2 gene

GDF5² GDF3² BMP5² GDF6² BMP8B² BMP4² GDF7² GDF2²

BMP10² BMP3² BMP7² GDF10² GDF1² BMP8A² BMP6²

14 SIMAP similar genes for BMP2 using alignment to 10 protein entries: BMP2_HUMAN (see all proteins):

BMP3 BMP4 TGFB1 DKFZp686A06204 INHA BMPY

GDF5 GDF3 BMP8A GDF3A BMP10 BMP6

BMP8B BMP7

BMP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60308736^1,2	C,	--	6703956(+)	`CTGACT/CTTTTT`	1	--	us2k¹		3		NA WA	240
rs75328734^1,2	F,	--	6704098(+)	`GAAGGG/ACAGAA`	1	--	us2k¹		3		CSA WA	122
rs6107869^1,2	C,F,H,	--	6704447(+)	`GTTACA/GCACAT`	1	--	us2k¹		19		NS EA NA	2078
rs7274657^1,2	C,	--	6704598(+)	`gtaacT/Cataaa`	1	--	us2k¹		2		WA	120
rs1979854^1,2	F,	--	6704755(-)	`AATAGG/CAGGAA`	1	--	us2k¹ trp³		1		WA	118
rs6117425^1,2	C,F,H	--	6704820(+)	`ATTGAG/AGtgtt`	1	--	us2k¹		3		NS NA	358
rs35123420^1,2		--	6705491(+)	`CTGCTG/CCCCGG`	1	--	us2k¹		2		NA	122
rs79555803^1,2		--	6705494(+)	`CTGCCC/TGGGCT`	1	--	us2k¹		0	--	--	--	--
rs2516847^1,2	C	--	6706060(+)	`CACTCC/TTCCCC`	1	--	ut5¹ trp³		0	--	--	--	--
rs79792785^1,2		--	6706915(+)	`AATGCG/AAGGGG`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for BMP2 (6748311 - 6760910 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BMP2: --
Human Gene Mutation Database (HGMD): BMP2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BMP2

DNA2.0 Custom Variant and Variant Library Synthesis for BMP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BMP2 for disorders           About GeneDecksing

OMIM gene information: 112261
OMIM disorders: 235200
20/132 diseases for BMP2 (see all 132):    About MalaCards

ossification of posterior longitudinal ligament of spine fibrodysplasia ossificans progressiva malignant peripheral nerve sheath tumor wolff-parkinson-white syndrome

hfe hemochromatosis, modifier of degenerative disc disease trigeminal neuralgia avascular necrosis of femoral head

malignant fibrous histiocytoma fibrous histiocytoma brachydactyly type a2 sudden infant death syndrome

root resorption non-small cell lung carcinoma aortic valve stenosis smooth muscle tumor

osteogenesis imperfecta traumatic brain injury male germ cell tumor primary pulmonary hypertension

9 diseases from the University of Copenhagen DISEASES database for BMP2:

Osteoporosis Ankylosis Osteonecrosis Root resorption

Degenerative disc disease Spondylolisthesis Osteoarthritis Cancer

Radiculopathy

10/90 Novoseek disease relationships for BMP2 gene (see all 90) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcification	66.7	84	18179800 (5), 20307738 (5), 14587031 (4), 16037577 (3) (see all 39)
arthrodesis	64.7	30	19411467 (3), 19487515 (2), 15966907 (2), 19571082 (2) (see all 22)
ossification heterotopic	54.5	6	16903944 (2), 19043134 (1), 11600747 (1), 16619272 (1) (see all 5)
osteosarcoma	53.6	30	16470222 (3), 10491221 (2), 17022972 (2), 10814523 (2) (see all 22)
degenerative disc disease	51.6	2	17669279 (2)
osteoporosis	51.2	28	16753015 (3), 14691541 (3), 11240412 (1), 16470007 (1) (see all 16)
pseudarthrosis	51.1	4	19226004 (1), 19579208 (1), 20228711 (1)
furcation defects	41.7	2	15966907 (2)
lumbar disc disease	39.6	3	19411467 (2), 15198497 (1)
seroma	37.7	3	20495420 (2), 18827703 (1)

Genetic Association Database (GAD): BMP2
Human Genome Epidemiology (HuGE) Navigator: BMP2 (44 documents)

Export disorders for BMP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BMP2 gene, integrated from 9 sources (see all 1428):
(articles sorted by number of sources associating them with BMP2)

Utopia: connect your pdf to the dynamic
world of online information

Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution. (PubMed id 10074410)^{1, 2, 9} Scheufler C.... Huelsmeyer M. (1999)
Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily. (PubMed id 2376592)^{1, 3, 9} Sampath T.K....Rueger D.C. (1990)
Posttranslational activation of bone morphogenetic pr otein 2 is mediated by proprotein convertase 6 during decidualization for pregn ancy establishment. (PubMed id 20555025)^{1, 2} Heng S....Nie G. (2010)
USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. (PubMed id 15020244)^{1, 2} Yanagita M.... Sakurai T. (2004)
Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development. (PubMed id 15240857)^{1, 4} Weese-Mayer D.E....Marazita M.L. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Novel regulators of bone formation: molecular clones and activities. (PubMed id 3201241)^{1, 2} Wozney J.M.... Wang E.A. (1988)
Alphavbeta integrins play an essential role in BMP-2 induction of osteoblast differentiation. (PubMed id 15647827)^{1, 9} Lai C.F. and Cheng S.L. (2005)
Porous silk fibroin 3-D scaffolds for delivery of bone morphogenetic protein-2 in vitro and in vivo. (PubMed id 16637042)^{1, 9} Karageorgiou V....Kaplan D.L. (2006)
Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells. (PubMed id 14587031)^{1, 9} Zebboudj A.F....Bostrom K. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 650	HGNC: 1069	AceView: BMP2	Ensembl:ENSG00000125845	euGenes: HUgn650
ECgene: BMP2	Kegg: 650	H-InvDB: BMP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BMP2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BMP2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_2

Intellectual Property for BMP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BMP2 gene:
Search GeneIP for patents involving BMP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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bone morphogenetic protein 2

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LUNG TUMOR
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BMP2 Gene

bone morphogenetic protein 2

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