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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BMP2 Gene

protein-coding   GIFtS: 71
GCID: GC20P006696

Bone Morphogenetic Protein 2


(Previous symbol: BMP2A)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bone Morphogenetic Protein 21 2
BMP2A1 2 3 5
Bone Morphogenetic Protein 2A2 3
BMP-2A2 3
BDA22
BMP-23

External Ids:    HGNC: 10691   Entrez Gene: 6502   Ensembl: ENSG000001258457   OMIM: 1122615   UniProtKB: P126433   

Export aliases for BMP2 gene to outside databases

Previous GC identifers: GC20P006737 GC20P006744


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BMP2 Gene:
The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded
protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. (provided by RefSeq, Jul
2008)

GeneCards Summary for BMP2 Gene: 
BMP2 (bone morphogenetic protein 2) is a protein-coding gene. Diseases associated with BMP2 include tympanosclerosis, and 20p12.3 microdeletion syndrome, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and BMP signalling and regulation. GO annotations related to this gene include growth factor activity and protein heterodimerization activity. An important paralog of this gene is GDF5.

UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643
Function: Induces cartilage and bone formation

Gene Wiki entry for BMP2 (Bone morphogenetic protein 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMP2 gene promoter:
         MEF-2A   AML1a   aMEF-2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BMP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p12

BMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P006696:  view genomic region     (about GC identifiers)

Start:
6,748,311 bp from pter      End:
6,760,927 bp from pter
Size:
12,617 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643 (See protein sequence)
Recommended Name: Bone morphogenetic protein 2 precursor  
Size: 396 amino acids; 44702 Da
Subunit: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts
with ASPN (By similarity)
Subcellular location: Secreted
6/11 PDB 3D structures from and Proteopedia for BMP2 (see all 11):
1ES7 (3D)        1REU (3D)        1REW (3D)        2GOO (3D)        2H62 (3D)        2H64 (3D)    

Explore the universe of human proteins at neXtProt for BMP2: NX_P12643

Explore proteomics data for BMP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12643

  • BMP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BMP2 Protein Expression
    REFSEQ proteins: NP_001191.1  
    ENSEMBL proteins: 
     ENSP00000368104  
    Reactome Protein details: P12643
    Human Recombinant Protein Products for BMP2: 
    EMD Millipore Purified and/or Recombinant BMP2 Protein
    R&D Systems Recombinant & Natural Proteins for BMP2 (BMP-2, BMP-2/BMP-6 Heterodimer, BMP-2/BMP-7 Heterodimer)
    Enzo Life Sciences proteins for BMP2
    OriGene Purified Protein for BMP2
    OriGene Protein Over-expression Lysate for BMP2
    OriGene MassSpec for BMP2 
    OriGene Custom Protein Services for BMP2
    GenScript Purified and Recombinant Proteins for BMP2
    Novus Biologicals BMP2 Proteins
    Novus Biologicals BMP2 Lysates
    Sino Biological Recombinant Protein for BMP2
    Sino Biological Cell Lysate for BMP2 
    ProSpec Recombinant Protein for BMP2
    Cloud-Clone Corp. Proteins for BMP2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0009986cell surface IDA--

    BMP2 for ontologies           About GeneDecksing



    BMP2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BMP2
    R&D Systems Antibodies for BMP2 (BMP-2, BMP-2/BMP-4, BMP-2/BMP-7 Heterodimer)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BMP2
    GenScript Custom Superior Antibodies Services for BMP2
    Novus Biologicals BMP2 Antibodies
    Abcam antibodies for BMP2
    Cloud-Clone Corp. Antibodies for BMP2 
    ThermoFisher Antibodies for BMP2
    LSBio Antibodies in human, mouse, rat for BMP2 

    Assay Products for BMP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BMP2
    R&D Systems ELISAs for BMP2 (BMP-2)         (see all)
    GenScript Custom Assay Services for BMP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BMP2 
    Cloud-Clone Corp. CLIAs for BMP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BMP: Bone morphogenetic proteins

    5 InterPro protein domains:
     IPR002405 Inhibin_asu
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry P12643

    ProtoNet protein and cluster: P12643

    2 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)


    UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643
    Similarity: Belongs to the TGF-beta family


    BMP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP2_HUMAN, P12643
    Function: Induces cartilage and bone formation

         Genatlas biochemistry entry for BMP2:
    bone morphogenetic protein 2 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),regulating
    myogenesis through dosage-dependent PAX3 expression in pre-myogenic cells,expressed in mesoderm under SHM control
    throuhg the mediaton of SOX9,involved in bone formation

         Summary:
    During embryonic development, BMP2 as signaling molecule is secreted from the following cells: Apical Ectodermal Ridge Cells in Limb Ectoderm, Cardiomyocytes in Inner Curvature (see all 20).

    It affects the following cells: Chondrocytes in Rostral Synchondroses, Chondrocytes in Synchondroses (see all 69).

    BMP2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Cardiomyocyte-like cells from Heart, Hypertrophic chondrocytes like cells from Cartilage (see all).

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004745retinol dehydrogenase activity ISS--
    GO:0005102receptor binding TAS2315314
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding IPI10881198
    GO:0008083growth factor activity IEA--
         
    BMP2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for BMP2:
     Cell division defect  Decreased cell number, increas  Metaphase cells 

         14 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Bmp2):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hearing/vestibular/ear  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
     nervous system  normal  reproductive system  skeleton 

    BMP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BMP2: Bmp2tm1Brd Bmp2tm1.1Jfm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BMP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BMP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BMP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BMP2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BMP2
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP2 (see all 50):
    hsa-miR-4291 hsa-miR-140-5p hsa-miR-142-5p hsa-miR-607 hsa-miR-106a hsa-miR-374a hsa-miR-759 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidBMP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BMP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BMP2
    Sirion Biotech Customized adenovirus for overexpression of BMP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BMP2 (see all 7)
    OriGene ORF clones in mouse, rat for BMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP2 (NM_001200)
    Sino Biological Human cDNA Clone for BMP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP2
    Sirion Biotech Customized lentivirus for stable overexpression of BMP2 
                         Customized lentivirus expression plasmids for stable overexpression of BMP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BMP2
    LifeMap BioReagents: cell lines associated with BMP2: PureStem MEL2, NCr-fac Progenitor,
    PureStem Z11, Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BMP2 About   (see all 33)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Signaling by BMP
    Signaling by BMP0.35
    BMP signalling and regulation0.35
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/74 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BMP2 (see all 74)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    5/6 BioSystems Pathways for BMP2 (see all 6)
        Senescence and Autophagy
    Heart Development
    Adipogenesis
    BMP signalling and regulation
    BDNF signaling pathway

    1 Sino Biological Pathway for BMP2 
        TGF-beta Signaling Pathway

    5        Reactome Pathways for BMP2
        Molecules associated with elastic fibres
    Extracellular matrix organization
    Elastic fibre formation
    Signal Transduction
    Signaling by BMP


    5/6         Kegg Pathways  (Kegg details for BMP2) (see all 6):
        Cytokine-cytokine receptor interaction
    Hedgehog signaling pathway
    TGF-beta signaling pathway
    Hippo signaling pathway
    Pathways in cancer


    BMP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BMP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for BMP2 (P126431, 2, 3 ENSP000003681044) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR1AP368941, 2, 3EBI-1029262,EBI-1029237 MINT-7261613 MINT-7261693 MINT-7261751 MINT-7990950 MINT-7261681 MINT-7261597 MINT-7261806 MINT-7261817 MINT-7261794 MINT-7261846 MINT-8044230 I2D: score=5 
    DIP2AQ146892, 3, ENSP000003920664MINT-7991072 I2D: score=1 STRING: ENSP00000392066
    BMPR1BO002382, 3, ENSP000002645684MINT-7264575 MINT-7264562 MINT-7264587 I2D: score=3 STRING: ENSP00000264568
    NOGQ132532, 3, ENSP000003281814MINT-7261628 MINT-7261642 I2D: score=2 STRING: ENSP00000328181
    FSTL1Q128412, 3, ENSP000002956334MINT-7990960 MINT-7990865 I2D: score=1 STRING: ENSP00000295633
    About this table

    Gene Ontology (GO): 5/87 biological process terms (GO ID links to tree view) (see all 87):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA19736317
    GO:0000187activation of MAPK activity IDA17202865
    GO:0001501skeletal system development TAS2315314
    GO:0001649osteoblast differentiation IDA15150273
    GO:0001658branching involved in ureteric bud morphogenesis ISS--

    BMP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BMP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BMP2

    UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643
    Pharmaceutical: Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft
    fractures

    1 HMDB Compound for BMP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    10/101 Novoseek inferred chemical compound relationships for BMP2 gene (see all 101)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alizarin 72.7 11 17236579 (1), 20395805 (1), 17300917 (1), 19146860 (1) (see all 10)
    hydroxyapatite 68.8 108 10853181 (4), 17189469 (3), 17617550 (3), 10512384 (2) (see all 50)
    atelocollagen 63.8 6 9565272 (2), 11168221 (1), 18404714 (1), 11502864 (1)
    titanium 60 58 17618492 (4), 19216269 (3), 19767180 (2), 16683108 (2) (see all 27)
    alizarin red s 59.6 1 15105665 (1)
    poly-p-dioxanone 57.7 3 16564087 (2), 16479565 (1)
    poly(dl-lactide-co-glycolide) 53.9 13 9552326 (2), 10357135 (1), 9584385 (1), 10679684 (1) (see all 7)
    dexamethasone 51.9 108 15183687 (9), 17512555 (6), 12854828 (4), 18404732 (3) (see all 51)
    poly-d 51.4 2 11936403 (1), 9592717 (1)
    alginate 45.3 18 17321862 (4), 15219571 (3), 18950289 (3), 16649180 (2) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about BMP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BMP2 gene: 
    NM_001200.2  

    Unigene Cluster for BMP2:

    Bone morphogenetic protein 2
    Hs.73853  [show with all ESTs]
    Unigene Representative Sequence: NM_001200
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000378827(uc002wmu.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate BMP2 (see all 50):
    hsa-miR-4291 hsa-miR-140-5p hsa-miR-142-5p hsa-miR-607 hsa-miR-106a hsa-miR-374a hsa-miR-759 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidBMP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP2
    Clone
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    OriGene clones in human, mouse for BMP2 (see all 7)
    OriGene ORF clones in mouse, rat for BMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BMP2 (NM_001200)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BMP2
    Sirion Biotech Customized lentivirus for stable overexpression of BMP2 
                         Customized lentivirus expression plasmids for stable overexpression of BMP2 
    Primer
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    OriGene qPCR primer pairs and template standards for BMP2
    OriGene qSTAR qPCR primer pairs in human, mouse for BMP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BMP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BMP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP2

    Additional mRNA sequence: 

    BC069214.1 M22489.1 

    2 DOTS entries:

    DT.113271  DT.100813580 

    24/84 AceView cDNA sequences (see all 84):

    M22489 AA583044 BU625617 AI084926 BM683313 BQ890465 BM993226 BM670141 
    AA489383 CR618407 NM_001200 BX101090 BC069214 AA630607 CB132019 BQ003843 
    BF437206 AA488371 AI379163 CB163046 AA181547 AA010702 BM670241 BX424086 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BMP2 expression in normal human tissues (normalized intensities)      BMP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGTGGAGG
    BMP2 Expression
    About this image


    BMP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/40 selected tissues (see all 40) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 29 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
             Mandibular Process
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 16 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Kidney (Urinary System)    fully expand to see all 13 entries
             Distal Renal Vesicle Cells Renal Vesicle
             S-shaped Body
             Human Renal Epithelial Cells (HREpiC)   
             visceral organ/metanephros/renal cortex   
     
     Heart (Cardiovascular System)    fully expand to see all 7 entries
             Cardiomyocytes Outflow Tract
             Heart Tube
             DKK1-induced cells ( Derivation of cardiomyocytes from pluripotent stem cells and...
     
     Endothelium (Cardiovascular System)    fully expand to see all 7 entries
             Human corneal endothelial cells
             Human Hepatic Sinusoidal Endothelial Cells (HHSEC)   
             huvec   

    See BMP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BMP2

    SOURCE GeneReport for Unigene cluster: Hs.73853

    UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643
    Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart,
    brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including BMP2 (see all 16): 
              Osteogenesis in human mouse rat
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BMP2 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp21 , 5 bone morphogenetic protein 21, 5 87.31(n)1
    92.39(a)1
      2 (65.21 cM)5
    121561  NM_007553.21  NP_031579.21 
     1335521595 
    chicken
    (Gallus gallus)
    Aves BMP21 bone morphogenetic protein 2 79.37(n)
    81.33(a)
      378779  NM_204358.1  NP_989689.1 
    lizard
    (Anolis carolinensis)
    Reptilia BMP26
    --
    Uncharacterized protein
    76(a)
    46(a)
    1 ↔ 1
    possible ortholog
    1(136433007-136452699)
    LGf(3407164-3410255)
    African clawed frog
    (Xenopus laevis)
    Amphibia X63424.12   -- 76.16(n)    X63424.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_131359.12   -- 72.92(n)   30631  NM_131359.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dpp1 , 3 TGFbeta receptor signaling pathway
    transforming more3
    decapentaplegic1
    40(a)3
    49.82(n)1
    42.78(a)1
      334321  NM_057963.41  NP_477311.11 


    ENSEMBL Gene Tree for BMP2 (if available)
    TreeFam Gene Tree for BMP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BMP2 gene
    GDF52  BMP52  GDF32  BMP8B2  GDF62  BMP42  GDF72  GDF22  
    BMP102  BMP32  BMP72  GDF102  GDF12  BMP8A2  BMP62  
    11 SIMAP similar genes for BMP2 using alignment to 10 protein entries:     BMP2_HUMAN (see all proteins):
    BMP3    BMP4    TGFB1    DKFZp686A06204    INHA    BMPY
    GDF5    GDF3    BMP8A    GDF3A    BMP10

    BMP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/301 SNPs in BMP2 are shown (see all 301)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423288701,2
    --6694057(+) CTCCCC/TTACCG 1 -- us2k10--------
    rs603087361,2
    C--6694114(+) CTGACT/CTTTTT 1 -- us2k13Minor allele frequency- C:0.06NA WA 240
    rs753287341,2
    C,F--6694256(+) GAAGGG/ACAGAA 1 -- us2k13Minor allele frequency- A:0.15CSA WA 122
    rs1446364161,2
    --6694273(+) GGCCCC/GAGACT 1 -- us2k10--------
    rs1820435631,2
    --6694479(+) CTCTGA/GGCTGC 1 -- us2k10--------
    rs1458408811,2
    --6694490(+) TAATCA/GCCTGC 1 -- us2k10--------
    rs749797661,2
    C,F--6694505(+) GAGCTG/AGGTGA 1 -- us2k12Minor allele frequency- A:0.10WA EA 238
    rs1490056861,2
    --6694568(+) CCCATC/GCATCC 1 -- us2k10--------
    rs61078691,2
    C,F,H--6694605(+) GTTACA/GCACAT 1 -- us2k119Minor allele frequency- G:0.05NS EA NA 2078
    rs19798551,2
    C,F,A,H--6694657(-) TCGGTT/CAATAT 1 -- us2k128Minor allele frequency- C:0.20NS EA NA WA 3132

    HapMap Linkage Disequilibrium report for BMP2 (6748311 - 6760927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BMP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833910CNV Gain17160897


    Human Gene Mutation Database (HGMD): BMP2
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for BMP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 112261   
    OMIM disorders: 235200  
    20/121 diseases for BMP2 (see all 121):    About MalaCards
    tympanosclerosis    20p12.3 microdeletion syndrome    trigeminal neuralgia    hfe hemochromatosis, modifier of
    degenerative disc disease    avascular necrosis of the femoral head    keutel syndrome    preterm premature rupture of the membranes
    brachydactyly type a2    fibrodysplasia ossificans progressiva    bone fracture    osteochondroma
    juvenile polyposis syndrome    osteosclerosis    periostitis    wolff-parkinson-white syndrome
    renal dysplasia    spondylolisthesis    osteomyelitis    malignant peripheral nerve sheath tumor

    9 diseases from the University of Copenhagen DISEASES database for BMP2:
    Osteoporosis     Ankylosis     Degenerative disc disease     Osteonecrosis
    Spondylolisthesis     Root resorption     Osteoarthritis     Cancer
    Radiculopathy

    BMP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/90 Novoseek inferred disease relationships for BMP2 gene (see all 90)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcification 66.7 84 18179800 (5), 20307738 (5), 14587031 (4), 16037577 (3) (see all 39)
    arthrodesis 64.7 30 19411467 (3), 19487515 (2), 15966907 (2), 19571082 (2) (see all 22)
    ossification heterotopic 54.5 6 16903944 (2), 19043134 (1), 11600747 (1), 16619272 (1) (see all 5)
    osteosarcoma 53.6 30 16470222 (3), 10491221 (2), 17022972 (2), 10814523 (2) (see all 22)
    degenerative disc disease 51.6 2 17669279 (2)
    osteoporosis 51.2 28 16753015 (3), 14691541 (3), 11240412 (1), 16470007 (1) (see all 16)
    pseudarthrosis 51.1 4 19226004 (1), 19579208 (1), 20228711 (1)
    furcation defects 41.7 2 15966907 (2)
    lumbar disc disease 39.6 3 19411467 (2), 15198497 (1)
    seroma 37.7 3 20495420 (2), 18827703 (1)

    Genetic Association Database (GAD): BMP2
    Human Genome Epidemiology (HuGE) Navigator: BMP2 (44 documents)

    Export disorders for BMP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BMP2 gene, integrated from 9 sources (see all 1458):
    (articles sorted by number of sources associating them with BMP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance. (PubMed id 17847004)1, 4, 9 Milet J....Mosser J. (2007)
    2. BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study. (PubMed id 16753015)1, 4, 9 Medici M....Uitterlinden A.G. (2006)
    3. Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution. (PubMed id 10074410)1, 2, 9 Scheufler C.... Huelsmeyer M. (1999)
    4. Variation in the bone morphogenetic protein-2 gene: effects on fat and lean body mass in young and elderly women. (PubMed id 18426824)1, 4, 9 McGuigan F....Akesson K. (2008)
    5. Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily. (PubMed id 2376592)1, 3, 9 Sampath T.K....Rueger D.C. (1990)
    6. Genetic heterogeneity in colorectal cancer associatio ns between African and European americans. (PubMed id 20659471)1, 4 Kupfer S.S....Ellis N.A. (2010)
    7. Genetic variants in COL2A1, COL11A2, and IRF6 contrib ute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Posttranslational activation of bone morphogenetic pr otein 2 is mediated by proprotein convertase 6 during decidualization for pregn ancy establishment. (PubMed id 20555025)1, 2 Heng S....Nie G. (2010)
    10. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 650 HGNC: 1069 AceView: BMP2 Ensembl:ENSG00000125845 euGenes: HUgn650
    ECgene: BMP2 Kegg: 650 H-InvDB: BMP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BMP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BMP2 gene:
    Search GeneIP for patents involving BMP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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