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Aliases for BMP2 Gene

Aliases for BMP2 Gene

  • Bone Morphogenetic Protein 2 2 3
  • Bone Morphogenetic Protein 2A 3 4
  • BMP-2A 3 4
  • BMP2A 3 4
  • BMP-2 4
  • BDA2 3

External Ids for BMP2 Gene

Previous HGNC Symbols for BMP2 Gene

  • BMP2A

Previous GeneCards Identifiers for BMP2 Gene

  • GC20P006737
  • GC20P006744

Summaries for BMP2 Gene

Entrez Gene Summary for BMP2 Gene

  • This gene encodes a member of the transforming growth factor-beta (TGFB) superfamily. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which induces bone and cartilage formation. [provided by RefSeq, Nov 2015]

GeneCards Summary for BMP2 Gene

BMP2 (Bone Morphogenetic Protein 2) is a Protein Coding gene. Diseases associated with BMP2 include 20p12.3 microdeletion syndrome and hemochromatosis. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include protein heterodimerization activity and cytokine activity. An important paralog of this gene is GDF3.

UniProtKB/Swiss-Prot for BMP2 Gene

  • Induces cartilage and bone formation

Gene Wiki entry for BMP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP2 Gene

Genomics for BMP2 Gene

Regulatory Elements for BMP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BMP2 Gene

Chromosome:
20
Start:
6,767,664 bp from pter
End:
6,780,280 bp from pter
Size:
12,617 bases
Orientation:
Plus strand

Genomic View for BMP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP2 Gene

Proteins for BMP2 Gene

  • Protein details for BMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12643-BMP2_HUMAN
    Recommended name:
    Bone morphogenetic protein 2
    Protein Accession:
    P12643

    Protein attributes for BMP2 Gene

    Size:
    396 amino acids
    Molecular mass:
    44702 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity). Interacts with MAFP5 (By similarity).

    Three dimensional structures from OCA and Proteopedia for BMP2 Gene

neXtProt entry for BMP2 Gene

Proteomics data for BMP2 Gene at MOPED

Post-translational modifications for BMP2 Gene

  • Glycosylation at Asn 135, Asn 163, Asn 164, Asn 200, and Asn 338
  • Modification sites at PhosphoSitePlus

Other Protein References for BMP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for BMP2 Gene

Domains & Families for BMP2 Gene

Gene Families for BMP2 Gene

Graphical View of Domain Structure for InterPro Entry

P12643

UniProtKB/Swiss-Prot:

BMP2_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with BMP2: view

Function for BMP2 Gene

Molecular function for BMP2 Gene

GENATLAS Biochemistry:
bone morphogenetic protein 2 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB superfamily),regulating myogenesis through dosage-dependent PAX3 expression in pre-myogenic cells,expressed in mesoderm under SHM control throuhg the mediaton of SOX9,involved in bone formation
UniProtKB/Swiss-Prot Function:
Induces cartilage and bone formation

LifeMap Function Summary for BMP2 Gene

During embryonic development, BMP2 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for BMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004745 retinol dehydrogenase activity ISS --
GO:0005102 receptor binding TAS 2315314
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005515 protein binding IPI 8413626
genes like me logo Genes that share ontologies with BMP2: view
genes like me logo Genes that share phenotypes with BMP2: view

Animal Models for BMP2 Gene

MGI Knock Outs for BMP2:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BMP2 Gene

Localization for BMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BMP2 Gene COMPARTMENTS Subcellular localization image for BMP2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
nucleus 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for BMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16604073
GO:0009986 cell surface IDA 22227436
GO:0070724 BMP receptor complex IDA 16604073
genes like me logo Genes that share ontologies with BMP2: view

Pathways & Interactions for BMP2 Gene

genes like me logo Genes that share pathways with BMP2: view

PCR Array Products

SIGNOR curated interactions for BMP2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9187146
GO:0000187 activation of MAPK activity IDA 17202865
GO:0001501 skeletal system development TAS 2315314
GO:0001649 osteoblast differentiation IDA 15150273
GO:0001658 branching involved in ureteric bud morphogenesis ISS --
genes like me logo Genes that share ontologies with BMP2: view

Drugs & Compounds for BMP2 Gene

(50) Drugs for BMP2 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 482
Alendronate Approved Pharma Inhibition, Inhibitor Bone resorption inhibitor, Osteoclast function modifiers (important in bone metastasis) 153
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Azathioprine Approved Pharma 145
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2525

(51) Additional Compounds for BMP2 Gene - From: NovoSeek

genes like me logo Genes that share compounds with BMP2: view

Transcripts for BMP2 Gene

mRNA/cDNA for BMP2 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(84) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BMP2 Gene

Bone morphogenetic protein 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BMP2 Gene

No ASD Table

Relevant External Links for BMP2 Gene

GeneLoc Exon Structure for
BMP2
ECgene alternative splicing isoforms for
BMP2

Expression for BMP2 Gene

mRNA expression in normal human tissues for BMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for BMP2 Gene Hs.73853

mRNA Expression by UniProt/SwissProt for BMP2 Gene

P12643-BMP2_HUMAN
Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine
genes like me logo Genes that share expression patterns with BMP2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BMP2 Gene

Orthologs for BMP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BMP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BMP2 35
  • 88.95 (n)
  • 94.18 (a)
BMP2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BMP2 35
  • 91.39 (n)
  • 94.68 (a)
BMP2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bmp2 35
  • 87.31 (n)
  • 92.39 (a)
Bmp2 16
Bmp2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BMP2 35
  • 99.24 (n)
  • 99.24 (a)
BMP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bmp2 35
  • 86.85 (n)
  • 92.11 (a)
oppossum
(Monodelphis domestica)
Mammalia BMP2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BMP2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves BMP2 35
  • 79.37 (n)
  • 81.33 (a)
BMP2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BMP2 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp2 35
  • 71.57 (n)
  • 73.86 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
bmp2b 35
  • 64.79 (n)
  • 68.97 (a)
bmp2a 36
  • 66 (a)
OneToMany
bmp2b 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dpp 37
  • 40 (a)
dpp 35
  • 50.09 (n)
  • 42.55 (a)
dpp 36
  • 28 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007987 35
  • 50.43 (n)
  • 47.86 (a)
worm
(Caenorhabditis elegans)
Secernentea dbl-1 37
  • 36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7273 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for BMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP2 Gene

ENSEMBL:
Gene Tree for BMP2 (if available)
TreeFam:
Gene Tree for BMP2 (if available)

Paralogs for BMP2 Gene

Paralogs for BMP2 Gene

genes like me logo Genes that share paralogs with BMP2: view

Variants for BMP2 Gene

Sequence variations from dbSNP and Humsavar for BMP2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs15705 -- 6,779,333(+) TATTT(A/C)GTTGT utr-variant-3-prime
rs170986 -- 6,779,784(+) CTCTC(A/C)TCCTG utr-variant-3-prime
rs235764 -- 6,773,599(+) ATTCC(A/G)AAGGT intron-variant
rs235765 -- 6,773,711(+) GGAAT(A/G)TTTTT intron-variant
rs235766 -- 6,774,523(+) CCTGT(C/G)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BMP2 Gene

Variant ID Type Subtype PubMed ID
nsv833910 CNV Gain 17160897

Variation tolerance for BMP2 Gene

Residual Variation Intolerance Score: 29.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BMP2 Gene

HapMap Linkage Disequilibrium report
BMP2
Human Gene Mutation Database (HGMD)
BMP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMP2 Gene

Disorders for BMP2 Gene

MalaCards: The human disease database

(47) MalaCards diseases for BMP2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
20p12.3 microdeletion syndrome
  • del(20)(p12.3)
hemochromatosis
  • hfe hemochromatosis, modifier of
brachydactyly, type a2
  • brachydactyly type a2
tympanosclerosis
osteonecrosis
  • avascular necrosis of bone
- elite association
Search BMP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BMP2

Genetic Association Database (GAD)
BMP2
Human Genome Epidemiology (HuGE) Navigator
BMP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BMP2
genes like me logo Genes that share disorders with BMP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BMP2 Gene

Publications for BMP2 Gene

  1. Osteoconductive conjugation of bone morphogenetic protein-2 onto titanium/titanium oxide surfaces coated with non-biofouling poly(poly(ethylene glycol) methacrylate). (PMID: 19767180) Kang S.M. … Choi I.S. (Colloids Surf B Biointerfaces 2010) 23 67
  2. BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. (PMID: 19835871) Kang M.H. … Yoo Y.A. (Exp. Cell Res. 2010) 23 67
  3. Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain. (PMID: 19861972) Smirkin A. … Tanaka J. (J. Cereb. Blood Flow Metab. 2010) 23 67
  4. Morphological differences during in vitro chondrogenesis of bone marrow-, synovium-MSCs, and chondrocytes. (PMID: 20010853) Ichinose S. … Sekiya I. (Lab. Invest. 2010) 23 67
  5. Identification of a key residue mediating bone morphogenetic protein (BMP)-6 resistance to noggin inhibition allows for engineered BMPs with superior agonist activity. (PMID: 20048150) Song K. … Alaoui-Ismaili M.H. (J. Biol. Chem. 2010) 23 67

Products for BMP2 Gene

Sources for BMP2 Gene

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