Aliases for BMP2 Gene
External Ids for BMP2 Gene
Previous HGNC Symbols for BMP2 Gene
Previous GeneCards Identifiers for BMP2 Gene
This gene encodes a member of the transforming growth factor-beta (TGFB) superfamily. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which induces bone and cartilage formation. [provided by RefSeq, Nov 2015]
GeneCards Summary for BMP2 Gene
BMP2 (Bone Morphogenetic Protein 2) is a Protein Coding gene. Diseases associated with BMP2 include brachydactyly, type a2 and hemochromatosis. Among its related pathways are Degradation of the extracellular matrix and Signaling by GPCR. GO annotations related to this gene include protein heterodimerization activity and cytokine activity. An important paralog of this gene is GDF3.
UniProtKB/Swiss-Prot for BMP2 Gene
Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).