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BMP2 Gene

protein-coding GIFtS: 66

GC20P006696

bone morphogenetic protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: BMP2A)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
BMP-2 ^³
BMP-2A ^³
BMP2A ^², ³, ⁵
OTTHUMP00000030228 ^²

Descriptions
bone morphogenetic protein 2 ^²

External Ids
HGNC: 1069¹
Entrez Gene: 650²
UniProtKB: P12643³
Ensembl: ENSG00000125845⁷

Search outside databases for aliases for BMP2 gene

Previous GC identifers: GC20P006737 GC20P006744

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for BMP2:

The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily.

The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation.

[provided by RefSeq]

UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643

Function: Induces cartilage and bone formation

Gene Wiki entry for BMP2 (Bone_morphogenetic_protein_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BMP2 gene

Entrez Gene cytogenetic band: 20p12 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20p12

BMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P006696: (about GC identifiers)

Start:	6,696,745 bp from pter
End:	6,708,910 bp from pter
Size:	12,166 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011387.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643 (See protein sequence)

Recommended Name: Bone morphogenetic protein 2 precursor

Size: 396 amino acids; 44702 Da

Subunit: Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1

Subcellular location: Secreted

PDB structures from and Proteopedia :

1ES7 (3D)

1REU (3D)

1REW (3D)

2GOO (3D)

2H62 (3D)

2H64 (3D)

2QJ9 (3D)

2QJA (3D)

2QJB (3D)

3BK3 (3D)

3BMP (3D)

REFSEQ proteins: NP_001191.1

ENSEMBL proteins:

ENSP00000368104

Human Recombinant Proteins

	Invitrogen human recombinant proteins for BMP2
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for BMP2
	R&D Systems Recombinant & Natural Proteins for BMP2 (BMP-2, BMP-2/BMP-7 Heterodimer)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ProBMP2, BMP2+4, BMP2)
	Human Recombinant Proteins from Abnova (BMP2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

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Antibodies for BMP2:

	Invitrogen Antibodies for BMP2
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for BMP2
	R&D Systems Antibodies for BMP2 (BMP-2)
	Antibodies from Abcam (ProBMP2, BMP2+4, BMP2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BMP2)
	Novus Biologicals Antibodies for BMP2

Assays for BMP2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for BMP2 (BMP-2) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P12643

ProtoNet protein and cluster: P12643

2 Blocks protein families:

IPB001111 Transforming growth factor beta (TGFb)

IPB001839 Transforming growth factor beta (TGFb)

UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643

Similarity: Belongs to the TGF-beta family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BMP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BMP2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001200

Applied Biosystems Silencer® siRNAs for BMP2

Sigma-Aldrich siRNA and siRNA Panels for BMP2

Sigma-Aldrich shRNA for BMP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001200
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001200
untagged cDNA clone in CMV expression vector: NM_001200

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001200

UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643

Function: Induces cartilage and bone formation

Genatlas biochemistry entry for BMP2:

bone morphogenetic protein 2 (Drosophila decapentaplegic-Vg-related,DVR family;TGFB

superfamily),regulating myogenesis through dosage-dependent PAX3 expression in pre-myogenic

cells,expressed in mesoderm under SHM control throuhg the mediaton of SOX9,involved in bone

formation

13 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Bmp2):

	craniofacial	embryogenesis	growth/size	homeostasis/metabolism
lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	muscle	nervous system
normal	reproductive system	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0008083	growth factor activity	IEA	--
GO:0016566	specific transcriptional repressor activity	IDA	15254224
GO:0046332	SMAD binding	IDA	18184661

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/10 Sigma-Aldrich "Your Favorite Gene" Pathways for BMP2 (Your Favorite Gene powered by Ingenuity) (see all 10 )

NF-&kappa
TGF-&beta
Factors Promoting Cardiogenesis in Vertebrates
BMP signaling pathway
Molecular Mechanisms of Cancer

GeneDecks BMP2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BMP2

5/171 Interacting proteins for BMP2 (ENSP00000368104³) via UniProtKB, MINT, and/or STRING (see all 171 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BMPR1A	ENSP00000361107³	STRING (score=.999)
BMPR1B	ENSP00000264568³	STRING (score=.999)
BMPR2	ENSP00000363708³	STRING (score=.999)
NOG	ENSP00000328181³	STRING (score=.999)
SOSTDC1	ENSP00000304930³	STRING (score=.999)

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5/21 Gene Ontology (GO) biological process terms (links to tree view) (see all 21 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001658	ureteric bud branching	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0007267	cell-cell signaling	TAS	2315314
GO:0008285	negative regulation of cell proliferation	IEA	--
GO:0009790	embryonic development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BMP2
10/41 Novoseek chemical compound relationships for BMP2 gene (see all 41 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hydroxyapatite	67.93	102	10853181 (4), 17189469 (3), 17617550 (3), 10512384 (2) (see all 46)
alizarin	65.16	8	17236579 (1), 17300917 (1), 19146860 (1), 16845965 (1) (see all 7)
atelocollagen	64.70	6	9565272 (2), 11168221 (1), 18404714 (1), 11502864 (1)
alizarin red s	60.95	1	15105665 (1)
poly-p-dioxanone	59.33	3	16564087 (2), 16479565 (1)
titanium	57.43	47	17618492 (4), 19216269 (3), 16683108 (2), 18651113 (2) (see all 23)
poly(dl-lactide-co-glycolide)	56.57	12	9552326 (2), 10357135 (1), 9584385 (1), 10397955 (1) (see all 7)
fibroin	46.32	10	15478212 (3), 16458961 (2), 16637042 (1), 18387349 (1)
procollagen	41.52	7	10085302 (2), 12925611 (1), 9069168 (1), 12440928 (1) (see all 5)
tgf beta1	40.17	11	18434375 (3), 8616889 (1), 15721136 (1), 9683824 (1) (see all 8)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BMP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BMP2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001200

Sigma-Aldrich siRNA and siRNA Panels for BMP2

Sigma-Aldrich shRNA for BMP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001200

REFSEQ mRNAs for BMP2 gene:

NM_001200.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001200

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001200
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001200
                                 untagged cDNA clone in CMV expression vector: NM_001200

Additional cDNA sequence:

BC069214.1 CR618407.1 M22489.1

2 DOTS entries:

DT.113271 DT.100813580

24/84 AceView cDNA sequences (see all 84 ):

AA181547 BM670141 BC069214 BQ003843 NM_001200 BQ890465 CB163046 BX101090

BM993226 AA630607 AA583044 BU625617 BM670241 M22489 AA489383 CB132019

AA010702 BF437206 CR618407 BM683313 AI379163 AI084926 AA488371 BQ186599

highest scoring ESTs for BMP2:

M22489 AA029824 AA181547 AA182439 AA190917 AA191431 AA436230 AA488371 AA488503 AA489442

Unigene Cluster for BMP2:

Bone morphogenetic protein 2

Hs.73853 [show with all ESTs]

Unigene Representative Sequence: NM_001200

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000378827

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BMP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BMP2

¹ / ² / ³

7 probe-sets matching BMP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1113_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.79	M22489	1.00	1.00	1.00	1
40367_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.91	M22489	1.00	1.00	1.00	1
59306_at²^{, 3}	U95-C	1	0.94	1.00	0.96	1.40	C75049	0.80	1.00	0.91	1
205289_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA583044	0.60	1.00	0.82	1
205290_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001200	0.60	1.00	0.82	1
205289_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205290_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks BMP2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTTGTGGAGG

SOURCE GeneReport for Unigene cluster: Hs.73853
Expression variation in blood from EXPOLDB for BMP2
UniProtKB/Swiss-Prot: BMP2_HUMAN, P12643
Tissue specificity: Particularly abundant in lung, spleen and colon and in low but significant
levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and
small intestine

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BMP2 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BMP2¹	--	bone morphogenetic protein 2	91.39(n) 94.68(a)	477162 XM_534351.2 XP_534351.2
chimpanzee (Pan troglodytes)	BMP2¹	--	bone morphogenetic protein 2	99.24(n) 99.24(a)	458090 XM_514508.2 XP_514508.2
cow (Bos taurus)	BMP2¹	--	bone morphogenetic protein 2	88.95(n) 94.18(a)	615037 XM_866011.2 XP_871104.1
rat (Rattus norvegicus)	Bmp2¹	--	bone morphogenetic protein 2	86.85(n) 92.11(a)	29373 NM_017178.1 NP_058874.1
mouse (Mus musculus)	Bmp2^{1, 5}	2 (76.10 cM)⁵	bone morphogenetic protein 2^{1, 5}	87.31(n)¹ 92.39(a)¹	12156¹ NM_007553.2¹ NP_031579.2¹ AF074942⁵ AI467020⁵ (see all 15)

About this table Species with no ortholog for BMP2

ENSEMBL Gene Tree for BMP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BMP2 gene

BMP10² BMP4² GDF2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/83 NCBI SNPs in BMP2 are shown (see all 83 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 54)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs235768^1,2	A,C,F,H	6707115(+)	`ACCAGT/ACTTTT`	1	S/R	mis¹ ese³		22	EA NA MN EU WA CSAM	1762
--	rs170986^1,2	A,C,F,H	6708431(+)	`CTCTCC/ATCCTG`	1	--	ut3¹ ese³ trp³		4	EU EA WA	412
	rs15705^1,2	A,C,F	6707980(+)	`TATTTA/CGTTGT`	1	--	ut3¹		1	MN	184
	rs235769^1,2	A,C,H	6708344(+)	`GAGTGG/ATTGTC`	1	--	ut3¹		2	MN WA	304
	rs3178250^1,2	C,F,H	6708201(+)	`TACTCT/CGGCAA`	1	--	ut3¹ ese³		5	MN EU EA WA	602
	rs2273074^1,2	C,H	6699089(+)	`GCCGAG/ACCAAC`	1	T/A	mis¹		5	EA EU WA	1908
	rs2273073^1,2	C,F	6698882(+)	`CGGCGT/GCGTCG`	1	A/S	mis¹ ese³		6	EA MN CSAM	1906
--	rs11545591^1,2	H	6707705(-)	`CCATGT/CCCTGA`	1	G/D	mis¹ ese³		4	EU EA WA	406
	rs34183594^1,2	F	6707027(+)	`TGCTTT/CAGGAA`	1	S/L	mis¹		5	MN CSAM EA	408
	rs36105541^1,2	F	6699002(+)	`TGCCCC/TCCTAC`	1	P/S	mis¹		5	MN CSAM EA	408

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HapMap Linkage Disequilibrium images for BMP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 112261 disorders: 235200

10/89 Novoseek disease relationships for BMP2 gene (see all 89 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcification	63.93	73	18179800 (5), 14587031 (4), 16037577 (3), 19028757 (3) (see all 36)
arthrodesis	63.46	25	19411467 (3), 15966907 (2), 11840099 (2), 8843392 (1) (see all 19)
ossification heterotopic	52.86	6	16903944 (2), 19043134 (1), 11600747 (1), 16619272 (1) (see all 5)
osteosarcoma	52.75	30	16470222 (3), 10491221 (2), 17022972 (2), 10814523 (2) (see all 22)
degenerative disc disease	49.96	2	17669279 (2)
osteoporosis	49.05	25	16753015 (3), 14691541 (3), 11240412 (1), 16470007 (1) (see all 13)
pseudarthrosis	48.14	2	19226004 (1)
furcation defects	43.98	2	15966907 (2)
lumbar disc disease	41.94	3	19411467 (2), 15198497 (1)
fibrodysplasia ossificans progressiva	36.66	1	1487246 (1)

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Human Gene Mutation Database: BMP2
Genetic Association Database: BMP2
Human Genome Epidemiology Navigator: BMP2 (15 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Additional Genetic Mutations Found in SIDS Babies: Focus is on the Autonomic Nervous System

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1060 PubMed articles for BMP2 gene (see all 1060 ):

Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution. (PubMed id 10074410)^{1, 3, 4} Scheufler C.... Huelsmeyer M. (1999)
Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily. (PubMed id 2376592)^{1, 2, 3} Sampath T.K....Rueger D.C. (1990)
USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. (PubMed id 15020244)^{3, 4} Yanagita M.... Sakurai T. (2004)
Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development. (PubMed id 15240857)^{3, 6} Weese-Mayer D.E....Marazita M.L. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Novel regulators of bone formation: molecular clones and activities. (PubMed id 3201241)^{3, 4} Wozney J.M.... Wang E.A. (1988)
Alphavbeta integrins play an essential role in BMP-2 induction of osteoblast differentiation. (PubMed id 15647827)^{1, 3} Lai C.F. and Cheng S.L. (2005)
Porous silk fibroin 3-D scaffolds for delivery of bone morphogenetic protein-2 in vitro and in vivo. (PubMed id 16637042)^{1, 3} Karageorgiou V....Kaplan D.L. (2006)
Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells. (PubMed id 14587031)^{1, 3} Zebboudj A.F....Bostrom K. (2003)
The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists. (PubMed id 11263668)^{1, 3} Nickel J....Sebald W. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 650	HGNC: 1069	AceView: BMP2	Ensembl:ENSG00000125845	euGenes: HUgn650
ECgene: BMP2	H-InvDB: BMP2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BMP2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_2

Licensable Technologies for BMP2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BMP2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BMP2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BMP2		Antibodies for BMP2
	Explore super-pooled esiRNAs		Proteins for BMP2
	Lentivirus-delivered shRNAs for BMP2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BMP2)
	Antibodies (BMP2)
	Chimera RNAi (BMP2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ProBMP2, BMP2+4, BMP2)
	Antibodies (ProBMP2, BMP2+4, BMP2)

Search OriGene for BMP2

Search Tocris compounds for BMP2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BMP2

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
BMP2 Gene at Home site.
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BMP2 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for BMP2

Summaries
for BMP2

Genomic Location
for BMP2

Proteins
for BMP2

Protein Domains/
Families
for BMP2

Gene Function
for BMP2

Pathways & Interactions
for BMP2

Drugs & Compounds
for BMP2

Transcripts
for BMP2

Expression
for BMP2

Orthologs
for BMP2

Paralogs
for BMP2

SNPs/Variants
for BMP2

Disorders & Mutations
for BMP2

Medical News
for BMP2

Publications
for BMP2

Search for BMP2

Genome Databases showing BMP2

Other Databases showing BMP2

Specialized Databases showing BMP2

Licensable Technologies
for BMP2

Services
for BMP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BMP2 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor BMP2

Summariesfor BMP2

Genomic Locationfor BMP2

Proteinsfor BMP2

Protein Domains/Familiesfor BMP2

Gene Functionfor BMP2

Pathways & Interactionsfor BMP2

Drugs & Compoundsfor BMP2

Transcriptsfor BMP2

Expression for BMP2

Orthologsfor BMP2

Paralogsfor BMP2

SNPs/Variantsfor BMP2

Disorders & Mutationsfor BMP2

Medical Newsfor BMP2

Publicationsfor BMP2

Search for BMP2

Genome Databases showing BMP2

Other Databases showing BMP2

Specialized Databases showing BMP2

Licensable Technologiesfor BMP2

Servicesfor BMP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BMP2

Summaries
for BMP2

Genomic Location
for BMP2

Proteins
for BMP2

Protein Domains/
Families
for BMP2

Gene Function
for BMP2

Pathways & Interactions
for BMP2

Drugs & Compounds
for BMP2

Transcripts
for BMP2

Expression
for BMP2

Orthologs
for BMP2

Paralogs
for BMP2

SNPs/Variants
for BMP2

Disorders & Mutations
for BMP2

Medical News
for BMP2

Publications
for BMP2

Licensable Technologies
for BMP2

Services
for BMP2