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Aliases for BMP15 Gene

Aliases for BMP15 Gene

  • Bone Morphogenetic Protein 15 2 3
  • GDF9B 3 4 6
  • Growth/Differentiation Factor 9B 3 4
  • BMP-15 3 4
  • GDF-9B 3 4
  • ODG2 3 6
  • POF4 3 6

External Ids for BMP15 Gene

Previous GeneCards Identifiers for BMP15 Gene

  • GC0XP049198
  • GC0XP048656
  • GC0XP049338
  • GC0XP049570
  • GC0XP050486
  • GC0XP050670
  • GC0XP048097

Summaries for BMP15 Gene

Entrez Gene Summary for BMP15 Gene

  • The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Defects in this gene are the cause of ovarian dysgenesis 2.[provided by RefSeq, Sep 2009]

GeneCards Summary for BMP15 Gene

BMP15 (Bone Morphogenetic Protein 15) is a Protein Coding gene. Diseases associated with BMP15 include ovarian dysgenesis 2 and 46,xx testicular disorder of sex development. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and growth factor activity. An important paralog of this gene is NODAL.

UniProtKB/Swiss-Prot for BMP15 Gene

  • May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.

Gene Wiki entry for BMP15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP15 Gene

Genomics for BMP15 Gene

Regulatory Elements for BMP15 Gene

Genomic Location for BMP15 Gene

Start:
50,910,735 bp from pter
End:
50,916,641 bp from pter
Size:
5,907 bases
Orientation:
Plus strand

Genomic View for BMP15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP15 Gene

Proteins for BMP15 Gene

  • Protein details for BMP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95972-BMP15_HUMAN
    Recommended name:
    Bone morphogenetic protein 15
    Protein Accession:
    O95972
    Secondary Accessions:
    • Q17RM6
    • Q5JST1
    • Q9UMS1

    Protein attributes for BMP15 Gene

    Size:
    392 amino acids
    Molecular mass:
    45055 Da
    Quaternary structure:
    • Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked
    Miscellaneous:
    • Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and influence species-specific ovulation-rates
    • The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa)

neXtProt entry for BMP15 Gene

Proteomics data for BMP15 Gene at MOPED

Post-translational modifications for BMP15 Gene

  • Glycosylation at Asn87, Asn147, Asn237, Thr277, and Asn373
  • Modification sites at PhosphoSitePlus

Other Protein References for BMP15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for BMP15 (BMP-15/GDF-9B)

No data available for DME Specific Peptides for BMP15 Gene

Domains for BMP15 Gene

Gene Families for BMP15 Gene

HGNC:
  • BMP :Bone morphogenetic proteins

Suggested Antigen Peptide Sequences for BMP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95972

UniProtKB/Swiss-Prot:

BMP15_HUMAN :
  • O95972
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with BMP15: view

Function for BMP15 Gene

Molecular function for BMP15 Gene

GENATLAS Biochemistry:
bone morphogenetic protein 15,expressed in oocytes,co-localized with GDF9,and likely involved in follicular development
UniProtKB/Swiss-Prot Function:
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.

Gene Ontology (GO) - Molecular Function for BMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with BMP15: view

Phenotypes for BMP15 Gene

genes like me logo Genes that share phenotypes with BMP15: view

Animal Models for BMP15 Gene

MGI Knock Outs for BMP15:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMP15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for BMP15 Gene

Localization for BMP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP15 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BMP15 Gene COMPARTMENTS Subcellular localization image for BMP15 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BMP15: view

Pathways for BMP15 Gene

genes like me logo Genes that share pathways with BMP15: view

Pathways by source for BMP15 Gene

Gene Ontology (GO) - Biological Process for BMP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0007292 female gamete generation TAS 9849956
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA --
GO:0030509 BMP signaling pathway IBA --
GO:0042981 regulation of apoptotic process IBA --
genes like me logo Genes that share ontologies with BMP15: view

Compounds for BMP15 Gene

(1) Novoseek inferred chemical compound relationships for BMP15 Gene

Compound -log(P) Hits PubMed IDs
progesterone 0 3
genes like me logo Genes that share compounds with BMP15: view

Transcripts for BMP15 Gene

mRNA/cDNA for BMP15 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BMP15

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BMP15 Gene

No ASD Table

Relevant External Links for BMP15 Gene

GeneLoc Exon Structure for
BMP15
ECgene alternative splicing isoforms for
BMP15

Expression for BMP15 Gene

mRNA expression in normal human tissues for BMP15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BMP15 Gene

This gene is overexpressed in Testis (35.6), Ovary (8.8), Cervix - Endocervix (4.4), and Lung (4.1).

Protein differential expression in normal tissues for BMP15 Gene

This gene is overexpressed in Monocytes (64.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BMP15 Gene

SOURCE GeneReport for Unigene cluster for BMP15 Gene Hs.532692

genes like me logo Genes that share expressions with BMP15: view

Expression partners for BMP15 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for BMP15 Gene

Orthologs for BMP15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BMP15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BMP15 35
  • 82.32 (n)
  • 74.54 (a)
BMP15 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BMP15 35
  • 83.46 (n)
  • 74.68 (a)
BMP15 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bmp15 35
  • 75.95 (n)
  • 64.43 (a)
Bmp15 16
Bmp15 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BMP15 35
  • 99.23 (n)
  • 98.47 (a)
BMP15 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bmp15 35
  • 75.62 (n)
  • 64.34 (a)
oppossum
(Monodelphis domestica)
Mammalia BMP15 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BMP15 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves BMP15 35
  • 54.26 (n)
  • 48.17 (a)
BMP15 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BMP15 36
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485893 35
  • 53.53 (n)
  • 47.12 (a)
Str.19786 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.18594 35
zebrafish
(Danio rerio)
Actinopterygii bmp15 35
  • 46.92 (n)
  • 34.17 (a)
wufi35a05 35
bmp15 36
  • 27 (a)
OneToOne
Species with no ortholog for BMP15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BMP15 Gene

ENSEMBL:
Gene Tree for BMP15 (if available)
TreeFam:
Gene Tree for BMP15 (if available)

Paralogs for BMP15 Gene

Paralogs for BMP15 Gene

genes like me logo Genes that share paralogs with BMP15: view

Variants for BMP15 Gene

Sequence variations from dbSNP and Humsavar for BMP15 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3810682 Benign 50,910,775(-) GAAAG(C/G)CTTAG utr-variant-5-prime
rs3897937 -- 50,912,016(+) TCTGT(A/G)GCCTT intron-variant
rs6614369 -- 50,909,839(+) CTGGG(A/C)TAGGT upstream-variant-2KB
rs6614608 -- 50,910,569(+) TGTTT(A/C)TGTTT upstream-variant-2KB
rs7471348 -- 50,912,015(+) ATCTG(C/T)AGCCT intron-variant

Relevant External Links for BMP15 Gene

HapMap Linkage Disequilibrium report
BMP15
Human Gene Mutation Database (HGMD)
BMP15
Locus Specific Mutation Databases (LSDB)
BMP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BMP15 Gene

Disorders for BMP15 Gene

(1) OMIM Diseases for BMP15 Gene (300247)

UniProtKB/Swiss-Prot

BMP15_HUMAN
  • Ovarian dysgenesis 2 (ODG2) [MIM:300510]: A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. {ECO:0000269 PubMed:15136966}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Premature ovarian failure 4 (POF4) [MIM:300510]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. {ECO:0000269 PubMed:16464940, ECO:0000269 PubMed:16508750, ECO:0000269 PubMed:16645022, ECO:0000269 PubMed:19263482, ECO:0000269 PubMed:19438907}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for BMP15 Gene

(7) Novoseek inferred disease relationships for BMP15 Gene

Disease -log(P) Hits PubMed IDs
ovarian failure premature 87.2 12
ovarian dysgenesis 73.9 1
infertility female 62.6 1
infertility 47.3 4
polycystic ovary syndrome 32.7 3

Relevant External Links for BMP15

Genetic Association Database (GAD)
BMP15
Human Genome Epidemiology (HuGE) Navigator
BMP15
genes like me logo Genes that share disorders with BMP15: view

No data available for Genatlas for BMP15 Gene

Publications for BMP15 Gene

  1. The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. (PMID: 9849956) Dube J.L. … Matzuk M.M. (Mol. Endocrinol. 1998) 2 3 4 23
  2. Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure. (PMID: 16645022) Laissue P. … Veitia R.A. (Eur. J. Endocrinol. 2006) 3 4 23 48
  3. Missense mutations in the BMP15 gene are associated with ovarian failure. (PMID: 16508750) Dixit H. … Singh L. (Hum. Genet. 2006) 3 4 23 48
  4. BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein. (PMID: 19263482) Rossetti R. … Persani L. (Hum. Mutat. 2009) 3 4 23 48
  5. Analyses of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) mutation in Chinese women with premature ovarian failure. (PMID: 19438907) Wang B. … Ma X. (Clin. Endocrinol. (Oxf.) 2010) 3 4 23

Products for BMP15 Gene

Sources for BMP15 Gene

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