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BMP15 Gene

protein-coding   GIFtS: 59
GCID: GC0XP050670

Bone Morphogenetic Protein 15

  See BMP15-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bone Morphogenetic Protein 151 2     GDF-9B2 3
GDF9B2 3 5     ODG22 5
Growth/Differentiation Factor 9B2 3     POF42 5
BMP-152 3     

External Ids:    HGNC: 10681   Entrez Gene: 92102   Ensembl: ENSG000001303857   OMIM: 3002475   UniProtKB: O959723   

Export aliases for BMP15 gene to outside databases

Previous GC identifers: GC0XP049198 GC0XP048656 GC0XP049338 GC0XP049570 GC0XP050486 GC0XP048097


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BMP15 Gene:
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the
transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large
families of growth and differentiation factors. It is thought that this protein may be involved in oocyte
maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9.
Defects in this gene are the cause of ovarian dysgenesis 2.(provided by RefSeq, Sep 2009)

GeneCards Summary for BMP15 Gene:
BMP15 (bone morphogenetic protein 15) is a protein-coding gene. Diseases associated with BMP15 include premature ovarian failure 4, and ovarian dysgenesis 2. GO annotations related to this gene include growth factor activity and cytokine activity. An important paralog of this gene is GDF15.

UniProtKB/Swiss-Prot: BMP15_HUMAN, O95972
Function: May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates
folliculogenesis and granulosa cell (GC) growth

Gene Wiki entry for BMP15 (Bone morphogenetic protein 15) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011630.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the BMP15 gene promoter:
         RP58   AML1a   MIF-1   STAT5A   Nkx2-5   NF-E2 p45   POU2F1   POU2F1a   Chx10   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP15 promoter sequence
   Search Chromatin IP Primers for BMP15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BMP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.2

BMP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP15 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP050670:  view genomic region     (about GC identifiers)

Start:
50,653,735 bp from pter      End:
50,659,641 bp from pter
Size:
5,907 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BMP15_HUMAN, O95972 (See protein sequence)
Recommended Name: Bone morphogenetic protein 15 precursor  
Size: 392 amino acids; 45055 Da
Subunit: Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked
Miscellaneous: The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa)
Miscellaneous: Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a
species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and
mammals such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig
can ovulate in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the
number of follicles that go onto ovulate during each reproductive cycle are poorly understood. According to
PubMed:21970812, mRNA expression levels of GDF9 and BMP15 are tightly coregulated within each species and
influence species-specific ovulation-rates
Secondary accessions: Q17RM6 Q5JST1 Q9UMS1

Explore the universe of human proteins at neXtProt for BMP15: NX_O95972

Explore proteomics data for BMP15 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn87, Asn147, Asn237, Thr277, Asn373
  • Modification sites at PhosphoSitePlus

  • See BMP15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005439.2  
    ENSEMBL proteins: 
     ENSP00000252677  

    BMP15 Human Recombinant Protein Products:

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    antibodies-online proteins for BMP15 (4 products) 

     
    antibodies-online peptides for BMP15

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    antibodies-online antibodies for BMP15 (54 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BMP: Bone morphogenetic proteins

    5 InterPro protein domains:
     IPR015615 TGF-beta-rel
     IPR015923 BMP-15
     IPR002405 Inhibin_asu
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry O95972

    ProtoNet protein and cluster: O95972

    2 Blocks protein domains:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002405 Inhibin alpha chain signature


    UniProtKB/Swiss-Prot: BMP15_HUMAN, O95972
    Similarity: Belongs to the TGF-beta family


    Find genes that share domains with BMP15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP15_HUMAN, O95972
    Function: May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates
    folliculogenesis and granulosa cell (GC) growth

         Genatlas biochemistry entry for BMP15:
    bone morphogenetic protein 15,expressed in oocytes,co-localized with GDF9,and likely involved in follicular
    development

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with BMP15           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bmp15):
     endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with BMP15           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bmp15tm1Zuk for BMP15

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BMP15
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BMP15_HUMAN, O95972: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    endoplasmic reticulum1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with BMP15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BMP15 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with BMP15           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BMP15 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway



    1 Kegg Pathway  (Kegg details for BMP15):
        Ovarian steroidogenesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BMP15
    Interactions:

        GeneGlobe Interaction Network for BMP15

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for BMP15 (O959723 ENSP000002526774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GDF9O603833, ENSP000002968754I2D: score=1 STRING: ENSP00000296875
    BMPR1BO002383, ENSP000002645684I2D: score=1 STRING: ENSP00000264568
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0007292female gamete generation TAS9849956
    GO:0045893positive regulation of transcription, DNA-templated IEA--
    GO:0060016granulosa cell development IEA--

    Find genes that share ontologies with BMP15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BMP15

    1 Novoseek inferred chemical compound relationship for BMP15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 0 6 12419820 (2), 17347167 (1)



    Find genes that share compounds with BMP15           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BMP15 gene: 
    NM_005448.2  

    Unigene Cluster for BMP15:

    Bone morphogenetic protein 15
    Hs.532692
    Unigene Representative Sequence: NM_005448
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252677(uc011mnw.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat BMP15

    Additional mRNA sequence: 

    BC069155.1 BC117264.1 BC117266.1 

    1 DOTS entry:

    DT.91935579 

    2 AceView cDNA sequences:

    NM_005448 BC069155 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BMP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATGACAG
    BMP15 Expression
    About this image


    BMP15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 6 entries
             Primary Oocyte Primary Follicle
             Secondary follicles
             Mature follicles
             oocyte   
     
     Gonad
             Primary Oocyte Primary Follicle
    BMP15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BMP15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532692
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BMP15 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp151 , 5 bone morphogenetic protein 151, 5 75.95(n)1
    64.43(a)1
      X (2.81 cM)5
    121551  NM_009757.41  NP_033887.11 
     63141075 
    chicken
    (Gallus gallus)
    Aves BMP151 bone morphogenetic protein 15 54.26(n)
    48.17(a)
      428697  NM_001006589.2  NP_001006589.2 
    lizard
    (Anolis carolinensis)
    Reptilia BMP156
    bone morphogenetic protein 15
    38(a)
    1 ↔ 1
    GL344585.1(17744-20559)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.185942 Xenopus laevis transcribed sequence with weak similarity more 75.33(n)    AW636224.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi35a052 Transcribed sequence with weak similarity to protein more 73.69(n)    57065642 


    ENSEMBL Gene Tree for BMP15 (if available)
    TreeFam Gene Tree for BMP15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BMP15 gene
    GDF152  GDF92  NODAL2  BMP32  GDF102  

    Find genes that share paralogs with BMP15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BMP15 (see all 174)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048947631,2,,4
    C,FPremature ovarian failure 4 (POF4)4 pathogenic150666022(+) CACTGC/TGGTAC 2 R W mis11Minor allele frequency- T:0.00NA 3478
    rs1148236071,2,,4
    C,FPremature ovarian failure 4 (POF4)4 --50670908(+) CAATCT/CCTCCT 2 /P /L mis11Minor allele frequency- C:0.01NA 4544
    VAR_0669334
    Premature ovarian failure 4 (POF4)4--see VAR_0669332 R C mis40--------
    VAR_0589754
    Premature ovarian failure 4 (POF4)4--see VAR_0589752 R Q mis40--------
    VAR_0589794
    Premature ovarian failure 4 (POF4)4--see VAR_0589792 R H mis40--------
    VAR_0589764
    Premature ovarian failure 4 (POF4)4--see VAR_0589762 R W mis40--------
    VAR_0211954
    Ovarian dysgenesis 2 (ODG2)4--see VAR_0211952 Y C mis40--------
    VAR_0589874
    Premature ovarian failure 4 (POF4)4--see VAR_0589872 W R mis40--------
    VAR_0589854
    Premature ovarian failure 4 (POF4)4--see VAR_0589852 N K mis40--------
    VAR_0589864
    Premature ovarian failure 4 (POF4)4--see VAR_0589862 R H mis40--------

    HapMap Linkage Disequilibrium report for BMP15 (50653735 - 50659641 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BMP15: --
    Human Gene Mutation Database (HGMD): BMP15
    Locus Specific Mutation Databases (LSDB): BMP15

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BMP15
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300247   
    OMIM disorders: 300510  
    UniProtKB/Swiss-Prot: BMP15_HUMAN, O95972
  • Ovarian dysgenesis 2 (ODG2) [MIM:300510]: A disorder characterized by lack of spontaneous pubertal
    development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak
    gonads. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Premature ovarian failure 4 (POF4) [MIM:300510]: An ovarian disorder defined as the cessation of ovarian
    function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of
    elevated levels of serum gonadotropins and low estradiol. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 5 diseases for BMP15:    
    About MalaCards
    premature ovarian failure 4    ovarian dysgenesis 2    ovarian dysgenesis 1    polycystic ovary syndrome
    premature ovarian failure

    4 diseases from the University of Copenhagen DISEASES database for BMP15:
    Premature ovarian failure     Infertility     Amenorrhea     Polycystic ovary syndrome

    Find genes that share disorders with BMP15           About GenesLikeMe

    7 Novoseek inferred disease relationships for BMP15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian failure premature 87.2 15 16645022 (2), 17027369 (2), 17464588 (2), 20364024 (2) (see all 8)
    ovarian dysgenesis 73.9 2 15836954 (1)
    infertility female 62.6 2 16818886 (1)
    infertility 47.3 7 10888873 (2), 15836954 (1), 18308851 (1)
    polycystic ovary syndrome 32.7 4 19376510 (2), 11056243 (1)
    turners syndrome 32.5 1 12478993 (1)
    tumors 2.58 1 16818886 (1)

    Genetic Association Database (GAD): BMP15
    Human Genome Epidemiology (HuGE) Navigator: BMP15 (13 documents)

    Export disorders for BMP15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BMP15 gene, integrated from 10 sources (see all 101):
    (articles sorted by number of sources associating them with BMP15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein. (PubMed id 19263482)1, 2, 4, 9 Rossetti R.... Persani L. (Hum. Mutat. 2009)
    2. Missense mutations in the BMP15 gene are associated with ovarian failure. (PubMed id 16508750)1, 2, 4, 9 Dixit H.... Singh L. (Hum. Genet. 2006)
    3. Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure. (PubMed id 16645022)1, 2, 4, 9 Laissue P.... Veitia R.A. (Eur. J. Endocrinol. 2006)
    4. The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. (PubMed id 9849956)1, 2, 3, 9 Dube J.L.... Matzuk M.M. (Mol. Endocrinol. 1998)
    5. Identification of new variants of human BMP15 gene in a large cohort of women with premature ovarian failure. (PubMed id 16464940)1, 2, 4 Di Pasquale E.... Persani L. (J. Clin. Endocrinol. Metab. 2006)
    6. Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene. (PubMed id 15136966)1, 2, 9 Di Pasquale E.... Persani L. (Am. J. Hum. Genet. 2004)
    7. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis. (PubMed id 10443672)1, 2, 9 Aaltonen J.... Ritvos O. (J. Clin. Endocrinol. Metab. 1999)
    8. Variants of the BMP15 gene in a cohort of patients with premature ovarian failure. (PubMed id 20364024)1, 4, 9 Tiotiu D....Delbaere A. (Hum. Reprod. 2010)
    9. Sequence variants in exons of the BMP-15 gene in Chinese patients with premature ovarian failure. (PubMed id 17464588)1, 4, 9 Zhang P....Chen Z.J. (Acta Obstet Gynecol Scand 2007)
    10. Characterization of the post-translational modification of recombinant human BMP-15 mature protein. (PubMed id 18227435)1, 2, 9 Saito S.... Shimasaki S. (Protein Sci. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9210 HGNC: 1068 AceView: BMP15 Ensembl:ENSG00000130385 euGenes: HUgn9210
    ECgene: BMP15 Kegg: 9210 H-InvDB: BMP15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BMP15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP15 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BMP15 gene:
    Search GeneIP for patents involving BMP15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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