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Aliases for BMP10 Gene

Aliases for BMP10 Gene

  • Bone Morphogenetic Protein 10 2 3
  • BMP-10 4

External Ids for BMP10 Gene

Summaries for BMP10 Gene

Entrez Gene Summary for BMP10 Gene

  • The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008]

GeneCards Summary for BMP10 Gene

BMP10 (Bone Morphogenetic Protein 10) is a Protein Coding gene. Diseases associated with BMP10 include muscle hypertrophy and hereditary hemorrhagic telangiectasia. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and hormone activity. An important paralog of this gene is BMP2.

UniProtKB/Swiss-Prot for BMP10 Gene

  • Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

Gene Wiki entry for BMP10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP10 Gene

Genomics for BMP10 Gene

Genomic Location for BMP10 Gene

Start:
68,865,481 bp from pter
End:
68,871,517 bp from pter
Size:
6,037 bases
Orientation:
Minus strand

Genomic View for BMP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP10 Gene

Regulatory Elements for BMP10 Gene

Proteins for BMP10 Gene

  • Protein details for BMP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95393-BMP10_HUMAN
    Recommended name:
    Bone morphogenetic protein 10
    Protein Accession:
    O95393
    Secondary Accessions:
    • Q53R17
    • Q6NTE0

    Protein attributes for BMP10 Gene

    Size:
    424 amino acids
    Molecular mass:
    48047 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for BMP10 Gene

Proteomics data for BMP10 Gene at MOPED

Post-translational modifications for BMP10 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn67 and Asn131

Other Protein References for BMP10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for BMP10 Gene

Domains for BMP10 Gene

Gene Families for BMP10 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • BMP :Bone morphogenetic proteins

Suggested Antigen Peptide Sequences for BMP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95393

UniProtKB/Swiss-Prot:

BMP10_HUMAN
Family:
  • Belongs to the TGF-beta family.:
    • O95393
genes like me logo Genes that share domains with BMP10: view

Function for BMP10 Gene

Molecular function for BMP10 Gene

UniProtKB/Swiss-Prot Function: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
UniProtKB/Swiss-Prot Induction: Down-regulated in some breast cancer subtypes and breast cancer cell lines.

LifeMap Function Summary for BMP10 Gene

It affects the following cells:

Gene Ontology (GO) - Molecular Function for BMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005179 hormone activity IDA 17921333
GO:0005515 protein binding IPI 17068149
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with BMP10: view

Phenotypes for BMP10 Gene

genes like me logo Genes that share phenotypes with BMP10: view

Animal Models for BMP10 Gene

MGI Knock Outs for BMP10:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for BMP10 Gene

Localization for BMP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BMP10 Gene COMPARTMENTS Subcellular localization image for BMP10 gene
Compartment Confidence
extracellular 4
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 17921333
GO:0005737 cytoplasm IDA 17921333
GO:0009986 cell surface IDA 17921333
GO:0030018 Z disc IDA 17921333
genes like me logo Genes that share ontologies with BMP10: view

Pathways for BMP10 Gene

genes like me logo Genes that share pathways with BMP10: view

Pathways by source for BMP10 Gene

Interacting Proteins for BMP10 Gene

Gene Ontology (GO) - Biological Process for BMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007507 heart development --
GO:0007512 adult heart development ISS 10072785
GO:0010596 negative regulation of endothelial cell migration IDA 17068149
GO:0010613 positive regulation of cardiac muscle hypertrophy IMP 17921333
genes like me logo Genes that share ontologies with BMP10: view

Transcripts for BMP10 Gene

mRNA/cDNA for BMP10 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BMP10 Gene

Bone morphogenetic protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BMP10 Gene

No ASD Table

Relevant External Links for BMP10 Gene

GeneLoc Exon Structure for
BMP10
ECgene alternative splicing isoforms for
BMP10

Expression for BMP10 Gene

mRNA expression in normal human tissues for BMP10 Gene

mRNA differential expression in normal tissues according to GTEx for BMP10 Gene

This gene is overexpressed in Heart - Atrial Appendage (52.7).

SOURCE GeneReport for Unigene cluster for BMP10 Gene Hs.158317

mRNA Expression by UniProt/SwissProt for BMP10 Gene

O95393-BMP10_HUMAN
Tissue specificity: Detected in mammary epithelia (at protein level).
genes like me logo Genes that share expressions with BMP10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for BMP10 Gene

Orthologs for BMP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for BMP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BMP10 35
  • 99.61 (n)
  • 99.76 (a)
BMP10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BMP10 35
  • 87.74 (n)
  • 89.86 (a)
BMP10 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BMP10 35
  • 87.5 (n)
  • 91.51 (a)
BMP10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bmp10 35
  • 83.53 (n)
  • 85.99 (a)
Bmp10 16
Bmp10 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BMP10 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BMP10 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bmp10 35
  • 82.9 (n)
  • 86.46 (a)
chicken
(Gallus gallus)
Aves BMP-10 36
  • 74 (a)
OneToOne
BMP10 35
  • 72.66 (n)
  • 74.7 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp10 35
  • 66.59 (n)
  • 64.55 (a)
zebrafish
(Danio rerio)
Actinopterygii bmp10 35
  • 62.01 (n)
  • 57.58 (a)
bmp10 36
  • 49 (a)
OneToMany
BMP10 (1 of 2) 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gbb 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dbl-1 35
  • 43.52 (n)
  • 33.12 (a)
dbl-1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for BMP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP10 Gene

ENSEMBL:
Gene Tree for BMP10 (if available)
TreeFam:
Gene Tree for BMP10 (if available)

Paralogs for BMP10 Gene

Paralogs for BMP10 Gene

Selected SIMAP similar genes for BMP10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BMP10: view

Variants for BMP10 Gene

Sequence variations from dbSNP and Humsavar for BMP10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2231337 -- 68,871,613(-) ATAGA(A/C)ACAAA upstream-variant-2KB
rs2231338 -- 68,871,364(-) CGAGC(A/G)GAGTC utr-variant-5-prime
rs2231339 -- 68,871,218(-) CAAGA(C/T)GGTGT reference, synonymous-codon
rs2231340 -- 68,870,946(-) TGATA(C/T)AGGTA intron-variant
rs2231341 -- 68,866,637(-) TTACA(G/T)AAATA intron-variant

Relevant External Links for BMP10 Gene

HapMap Linkage Disequilibrium report
BMP10
Human Gene Mutation Database (HGMD)
BMP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BMP10 Gene

Disorders for BMP10 Gene

(2) University of Copenhagen DISEASES for BMP10 Gene

Relevant External Links for BMP10

Genetic Association Database (GAD)
BMP10
Human Genome Epidemiology (HuGE) Navigator
BMP10
genes like me logo Genes that share disorders with BMP10: view

No data available for UniProtKB/Swiss-Prot for BMP10 Gene

Publications for BMP10 Gene

  1. Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy. (PMID: 17921333) Nakano N. … Kimura A. (Am. J. Physiol. Heart Circ. Physiol. 2007) 3 23
  2. Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. (PMID: 10072785) Neuhaus H. … Thies R.S. (Mech. Dev. 1999) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. (PMID: 16049014) Mazerbourg S. … Hsueh A.J.W. (J. Biol. Chem. 2005) 3 4

Products for BMP10 Gene

Sources for BMP10 Gene

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