Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BMP10 Gene

Aliases for BMP10 Gene

  • Bone Morphogenetic Protein 10 2 3 5
  • BMP-10 4

External Ids for BMP10 Gene

Previous GeneCards Identifiers for BMP10 Gene

  • GC02M069104
  • GC02M069290
  • GC02M069067
  • GC02M069004
  • GC02M069092
  • GC02M068828

Summaries for BMP10 Gene

Entrez Gene Summary for BMP10 Gene

  • This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016]

GeneCards Summary for BMP10 Gene

BMP10 (Bone Morphogenetic Protein 10) is a Protein Coding gene. Diseases associated with BMP10 include Feingold Syndrome and Heart Septal Defect. Among its related pathways are p70S6K Signaling and TGF-beta Signaling Pathway (sino). GO annotations related to this gene include cytokine activity and hormone activity. An important paralog of this gene is GDF2.

UniProtKB/Swiss-Prot for BMP10 Gene

  • Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.

Gene Wiki entry for BMP10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMP10 Gene

Genomics for BMP10 Gene

Regulatory Elements for BMP10 Gene

Enhancers for BMP10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BMP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for BMP10 Gene

Chromosome:
2
Start:
68,865,481 bp from pter
End:
68,871,517 bp from pter
Size:
6,037 bases
Orientation:
Minus strand

Genomic View for BMP10 Gene

Genes around BMP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BMP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BMP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMP10 Gene

Proteins for BMP10 Gene

  • Protein details for BMP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95393-BMP10_HUMAN
    Recommended name:
    Bone morphogenetic protein 10
    Protein Accession:
    O95393
    Secondary Accessions:
    • Q53R17
    • Q6NTE0

    Protein attributes for BMP10 Gene

    Size:
    424 amino acids
    Molecular mass:
    48047 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for BMP10 Gene

Post-translational modifications for BMP10 Gene

  • Glycosylation at Asn 67 and Asn 131
  • Modification sites at PhosphoSitePlus

Other Protein References for BMP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for BMP10
  • Cloud-Clone Corp. Antibodies for BMP10

No data available for DME Specific Peptides for BMP10 Gene

Domains & Families for BMP10 Gene

Gene Families for BMP10 Gene

Suggested Antigen Peptide Sequences for BMP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95393

UniProtKB/Swiss-Prot:

BMP10_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with BMP10: view

Function for BMP10 Gene

Molecular function for BMP10 Gene

UniProtKB/Swiss-Prot Function:
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
UniProtKB/Swiss-Prot Induction:
Down-regulated in some breast cancer subtypes and breast cancer cell lines.

LifeMap Function Summary for BMP10 Gene

It affects the following cells:

Gene Ontology (GO) - Molecular Function for BMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005179 hormone activity IDA 17921333
GO:0005515 protein binding IPI 17068149
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with BMP10: view
genes like me logo Genes that share phenotypes with BMP10: view

Animal Models for BMP10 Gene

MGI Knock Outs for BMP10:

Animal Model Products

  • Taconic Biosciences Mouse Models for BMP10

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BMP10 Gene

Localization for BMP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMP10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BMP10 Gene COMPARTMENTS Subcellular localization image for BMP10 gene
Compartment Confidence
extracellular 5
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 17921333
GO:0005737 cytoplasm IDA 17921333
GO:0009986 cell surface IDA 17921333
GO:0030018 Z disc IDA 17921333
genes like me logo Genes that share ontologies with BMP10: view

Pathways & Interactions for BMP10 Gene

genes like me logo Genes that share pathways with BMP10: view

SIGNOR curated interactions for BMP10 Gene

Activates:

Gene Ontology (GO) - Biological Process for BMP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007507 heart development IEA --
GO:0007512 adult heart development IEA,ISS 10072785
GO:0010596 negative regulation of endothelial cell migration IDA 17068149
GO:0010613 positive regulation of cardiac muscle hypertrophy IMP 17921333
genes like me logo Genes that share ontologies with BMP10: view

Drugs & Compounds for BMP10 Gene

(1) Drugs for BMP10 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dalantercept Pharma inhibitor ALK1 inhibitor 0
genes like me logo Genes that share compounds with BMP10: view

Transcripts for BMP10 Gene

mRNA/cDNA for BMP10 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BMP10 Gene

Bone morphogenetic protein 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BMP10 Gene

No ASD Table

Relevant External Links for BMP10 Gene

GeneLoc Exon Structure for
BMP10
ECgene alternative splicing isoforms for
BMP10

Expression for BMP10 Gene

mRNA expression in normal human tissues for BMP10 Gene

mRNA differential expression in normal tissues according to GTEx for BMP10 Gene

This gene is overexpressed in Heart - Atrial Appendage (x52.7).

NURSA nuclear receptor signaling pathways regulating expression of BMP10 Gene:

BMP10

SOURCE GeneReport for Unigene cluster for BMP10 Gene:

Hs.158317

mRNA Expression by UniProt/SwissProt for BMP10 Gene:

O95393-BMP10_HUMAN
Tissue specificity: Detected in mammary epithelia (at protein level).
genes like me logo Genes that share expression patterns with BMP10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BMP10 Gene

Orthologs for BMP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for BMP10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BMP10 34
  • 87.74 (n)
  • 89.86 (a)
BMP10 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BMP10 34
  • 87.5 (n)
  • 91.51 (a)
BMP10 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bmp10 34
  • 83.53 (n)
  • 85.99 (a)
Bmp10 16
Bmp10 35
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BMP10 34
  • 99.61 (n)
  • 99.76 (a)
BMP10 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bmp10 34
  • 82.9 (n)
  • 86.46 (a)
oppossum
(Monodelphis domestica)
Mammalia BMP10 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BMP10 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves BMP10 34
  • 72.66 (n)
  • 74.7 (a)
BMP-10 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bmp10 34
  • 66.59 (n)
  • 64.55 (a)
zebrafish
(Danio rerio)
Actinopterygii bmp10 34
  • 62.01 (n)
  • 57.58 (a)
bmp10 35
  • 49 (a)
OneToMany
BMP10 (1 of 2) 35
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gbb 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dbl-1 34
  • 43.52 (n)
  • 33.12 (a)
dbl-1 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToMany
Species where no ortholog for BMP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BMP10 Gene

ENSEMBL:
Gene Tree for BMP10 (if available)
TreeFam:
Gene Tree for BMP10 (if available)

Paralogs for BMP10 Gene

Paralogs for BMP10 Gene

(2) SIMAP similar genes for BMP10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BMP10: view

Variants for BMP10 Gene

Sequence variations from dbSNP and Humsavar for BMP10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2231342 - 68,866,307(+) GGAGA(C/G)TTTTG reference, missense
rs2231345 - 68,866,156(-) CATAA(A/C)CCTTT reference, missense
rs6706460 -- 68,871,349(+) GACCA(C/G)AGAGC reference, missense
rs2231337 -- 68,871,613(-) ATAGA(A/C)ACAAA upstream-variant-2KB
rs2231338 -- 68,871,364(-) CGAGC(A/G)GAGTC utr-variant-5-prime

Variation tolerance for BMP10 Gene

Residual Variation Intolerance Score: 55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BMP10 Gene

Human Gene Mutation Database (HGMD)
BMP10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BMP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BMP10 Gene

Disorders for BMP10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BMP10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
feingold syndrome
  • feingold syndrome 1
heart septal defect
  • cardiac septal defects
- elite association - COSMIC cancer census association via MalaCards
Search BMP10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BMP10

Genetic Association Database (GAD)
BMP10
Human Genome Epidemiology (HuGE) Navigator
BMP10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BMP10
genes like me logo Genes that share disorders with BMP10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BMP10 Gene

Publications for BMP10 Gene

  1. Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer. (PMID: 20608934) Ye L. … Jiang W.G. (Cancer Sci. 2010) 3 4 65
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 65
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 65
  5. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. (PMID: 17068149) David L. … Bailly S. (Blood 2007) 3 4 65

Products for BMP10 Gene

Sources for BMP10 Gene

Content