External Ids for BMP10 Gene
Previous GeneCards Identifiers for BMP10 Gene
The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008]
GeneCards Summary for BMP10 Gene
BMP10 (Bone Morphogenetic Protein 10) is a Protein Coding gene. Diseases associated with BMP10 include muscle hypertrophy and heart septal defect. Among its related pathways are TGF-Beta Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include cytokine activity and hormone activity. An important paralog of this gene is BMP2.
UniProtKB/Swiss-Prot for BMP10 Gene
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.