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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BMP10 Gene

protein-coding   GIFtS: 59
GCID: GC02M069092

Bone Morphogenetic Protein 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bone Morphogenetic Protein 101 2
BMP-103

External Ids:    HGNC: 208691   Entrez Gene: 273022   Ensembl: ENSG000001632177   OMIM: 6087485   UniProtKB: O953933   

Export aliases for BMP10 gene to outside databases

Previous GC identifers: GC02M069104 GC02M069290 GC02M069067 GC02M069004 GC02M068828


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BMP10 Gene:
The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the
similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein
may signal through receptor serine/threonine kinases. (provided by RefSeq, Jul 2008)

GeneCards Summary for BMP10 Gene: 
BMP10 (bone morphogenetic protein 10) is a protein-coding gene. Diseases associated with BMP10 include hereditary hemorrhagic telangiectasia, and ventricular septal defect, and among its related super-pathways are Rac1 Pathway and MIF Mediated Glucocorticoid Regulation. GO annotations related to this gene include growth factor activity and hormone activity. An important paralog of this gene is GDF5.

UniProtKB/Swiss-Prot: BMP10_HUMAN, O95393
Function: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature
activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of
cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6,
leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and
growth

Gene Wiki entry for BMP10 (Bone morphogenetic protein 10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMP10 gene promoter:
         Brachyury   HSF2   HOXA5   Nkx2-5   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBMP10 promoter sequence
   Search SABiosciences Chromatin IP Primers for BMP10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.3   Ensembl cytogenetic band:  2p13.3   HGNC cytogenetic band: 2p13.2

BMP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M069092:  view genomic region     (about GC identifiers)

Start:
69,092,613 bp from pter      End:
69,098,649 bp from pter
Size:
6,037 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BMP10_HUMAN, O95393 (See protein sequence)
Recommended Name: Bone morphogenetic protein 10 precursor  
Size: 424 amino acids; 48047 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: Q53R17 Q6NTE0

Explore the universe of human proteins at neXtProt for BMP10: NX_O95393

Explore proteomics data for BMP10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95393

  • BMP10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BMP10 Protein Expression
    REFSEQ proteins: NP_055297.1  
    ENSEMBL proteins: 
     ENSP00000295379  
    Reactome Protein details: O95393
    Human Recombinant Protein Products for BMP10: 
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    OriGene Protein Over-expression Lysate for BMP10
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    Novus Biologicals BMP10 Proteins
    Novus Biologicals BMP10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BMP10 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA17921333
    GO:0005737cytoplasm IDA17921333
    GO:0009986cell surface IDA17921333
    GO:0030018Z disc IDA17921333

    BMP10 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for BMP10 
    Cloud-Clone Corp. CLIAs for BMP10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BMP: Bone morphogenetic proteins

    5 InterPro protein domains:
     IPR002405 Inhibin_asu
     IPR001111 TGF-b_N
     IPR015615 TGF-beta-rel
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry O95393

    ProtoNet protein and cluster: O95393

    3 Blocks protein domains:
    IPB001111 Transforming growth factor beta (TGFb)
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: BMP10_HUMAN, O95393
    Similarity: Belongs to the TGF-beta family


    BMP10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BMP10_HUMAN, O95393
    Function: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature
    activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of
    cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6,
    leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and
    growth

         Summary:

    During embryonic development, BMP10 as signaling molecule
    affects the following cells: Cardiomyocytes in Myocardium

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005179hormone activity IDA17921333
    GO:0005515protein binding IPI17068149
    GO:0008083growth factor activity IEA--
    GO:0033612receptor serine/threonine kinase binding IDA17068149
         
    BMP10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BMP10:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bmp10):
     cardiovascular system  mortality/aging  muscle 

    BMP10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bmp10tm1Shou for BMP10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BMP10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BMP10

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    hsa-miR-582-5p
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BMP10 About   (see all 21)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/71 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BMP10 (see all 71)
        Telomerase Components in Cell Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    JNK Pathway

    1 BioSystems Pathway for BMP10
        Heart Development

    1 Sino Biological Pathway for BMP10 
        TGF-beta Signaling Pathway

    3        Reactome Pathways for BMP10
        Molecules associated with elastic fibres
    Extracellular matrix organization
    Elastic fibre formation



    BMP10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BMP10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for BMP10 (ENSP000002953794) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERINC3ENSP000002551754STRING: ENSP00000255175
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007507heart development ----
    GO:0007512adult heart development ISS10072785
    GO:0010596negative regulation of endothelial cell migration IDA17068149
    GO:0010613positive regulation of cardiac muscle hypertrophy IMP17921333

    BMP10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BMP10

    Search CenterWatch for drugs/clinical trials and news about BMP10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BMP10 gene: 
    NM_014482.1  

    Unigene Cluster for BMP10:

    Bone morphogenetic protein 10
    Hs.158317
    Unigene Representative Sequence: AF101441
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000295379(uc002sez.1)
    miRNA
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    Additional mRNA sequence: 

    AF101441.1 BC069080.1 BC101734.1 BC105063.1 

    1 DOTS entry:

    DT.92044941 

    4 AceView cDNA sequences:

    AF101441 NM_014482 BC069080 BM755159 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BMP10 expression in normal human tissues (normalized intensities)      BMP10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGTCTCCG
    BMP10 Expression
    About this image


    BMP10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Heart (Cardiovascular System)
             atrial myocardium   

    See BMP10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BMP10

    SOURCE GeneReport for Unigene cluster: Hs.158317
        SABiosciences Expression via Pathway-Focused PCR Array including BMP10: 
              Growth Factors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BMP10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BMP10 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bmp101 , 5 bone morphogenetic protein 101, 5 83.53(n)1
    85.99(a)1
      6 (37.96 cM)5
    121541  NM_009756.21  NP_033886.21 
     874290025 
    chicken
    (Gallus gallus)
    Aves BMP101 bone morphogenetic protein 10 72.66(n)
    74.7(a)
      395177  XM_417667.1  XP_417667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii bmp101 bone morphogenetic protein 10 60.9(n)
    56.4(a)
      562533  NM_001130600.1  NP_001124072.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dbl-16
    Protein DBL-1
    23(a)
    1 → many
    V(6758135-6760409)


    ENSEMBL Gene Tree for BMP10 (if available)
    TreeFam Gene Tree for BMP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BMP10 gene
    GDF52  BMP52  GDF32  BMP8B2  GDF62  BMP42  GDF72  GDF22  
    BMP22  BMP32  BMP72  GDF102  GDF12  BMP8A2  BMP62  
    2 SIMAP similar genes for BMP10 using alignment to 1 protein entry:     BMP10_HUMAN:
    GDF2    BMP2

    BMP10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/215 SNPs in BMP10 are shown (see all 215)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37922231,2
    C,F,H--68959048(+) TTGTAC/TCTCTA 1 -- ds500115Minor allele frequency- T:0.05EA NS NA 3266
    rs770344631,2
    C,F--68959064(+) TCTTAA/GGTCCA 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1484558091,2
    --68959164(+) AGCTAC/TACTTA 1 -- ds50010--------
    rs1875022101,2
    --68959208(+) CTAGGA/GTGATT 1 -- ds50010--------
    rs37922241,2
    C,F,A--68959297(+) ATGCAT/CACATT 1 -- ds50019Minor allele frequency- C:0.17NA WA CSA EA 480
    rs1929403571,2
    --68959380(+) GTACAA/CATATA 1 -- ds50010--------
    rs594024901,2
    --68959449(+) ACAGGG/TAGGTG 1 -- ds50010--------
    rs1476378521,2
    --68959504(+) GGGACC/TTAACT 1 -- ds50010--------
    rs101735461,2
    C,F--68959525(+) ATATGC/TATTTC 1 -- ut31 ese33Minor allele frequency- T:0.19WA CSA 122
    rs1127050241,2
    C,F--68959567(+) GGCAGC/AAAGCC 1 -- ut312Minor allele frequency- A:0.50CSA 4

    HapMap Linkage Disequilibrium report for BMP10 (69092613 - 69098649 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BMP10: --

    Human Gene Mutation Database (HGMD): BMP10
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing BMP10
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608748    OMIM disorders: --

    11 diseases for BMP10:    About MalaCards
    hereditary hemorrhagic telangiectasia    ventricular septal defect    hepatitis b    endotheliitis
    hypertension    hepatitis    prostate cancer    prostatitis
    adenocarcinoma    breast cancer    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for BMP10:
    Hereditary hemorrhagic telangiectasia     Ventricular septal defect

    BMP10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BMP10
    Human Genome Epidemiology (HuGE) Navigator: BMP10 (6 documents)

    Export disorders for BMP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BMP10 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with BMP10)
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    1. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. (PubMed id 17068149)1, 2 David L.... Bailly S. (2007)
    5. Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. (PubMed id 16049014)1, 2 Mazerbourg S....Hsueh A.J.W. (2005)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. (PubMed id 10072785)1, 3 Neuhaus H....Thies R.S. (1999)
    9. Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy. (PubMed id 17921333)1, 9 Nakano N....Kimura A. (2007)
    10. Expression of bone morphogenetic protein-10 (BMP10) in human urothelial cancer of the bladder and its effects on the aggressiveness of bladder cancer cells in vitro. (PubMed id 23645739)1 Zhang N....Jiang W.G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27302 HGNC: 20869 AceView: BMP10 Ensembl:ENSG00000163217 euGenes: HUgn27302
    ECgene: BMP10 H-InvDB: BMP10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BMP10 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Bone_morphogenetic_protein_10

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BMP10 gene:
    Search GeneIP for patents involving BMP10

    GeneCards and IP:
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